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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mdm2
Name: MDM2 proto-oncogene
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdm2increases expressionEXP 6480464CTDParaquat results in increased expression of MDM2 mRNAPMID:32680482
Mdm2increases expressionISOMDM2 (Homo sapiens)6480464CTDParaquat results in increased expression of MDM2 mRNAPMID:20883675 PMID:34097952
Mdm2multiple interactionsISOMdm2 (Mus musculus)6480464CTDGPX1 protein affects the reaction [Paraquat affects the expression of MDM2 mRNA]PMID:12654481
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