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GENE - TERM ANNOTATION REPORT

RGD ID: 12314261
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: OPRM1
Name: opioid receptor mu 1
Acc ID: DOID:1574
Term: alcohol use disorder
Definition: A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Alcohol_abuse "DO" "DO", https://www.niaaa.nih.gov/alcohol-health/overview-alcohol-consumption/alcohol-use-disorders "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
OPRM1no_associationISOOPRM1 (Homo sapiens)9068941RGDDNA:missense mutations, SNP:exon, intron:p.A6V, p.S147C, p.N40D (118A>G) (rs 1799971), IVS2+691G>C (human)PMID:9399694 REF_RGD_ID:401827934
OPRM1no_associationISOOPRM1 (Homo sapiens)9068941RGDDNA:SNP: :rs510769PMID:26042510 REF_RGD_ID:401827930
OPRM1treatmentISOOPRM1 (Homo sapiens)9068941RGDDNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human)PMID:32772383 REF_RGD_ID:401827947
OPRM1 ISOOPRM1 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:12815747
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