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GENE - TERM ANNOTATION REPORT

RGD ID: 11859614
Species: Pan paniscus
RGD Object: Gene
Symbol: EIF2B4
Name: eukaryotic translation initiation factor 2B subunit delta
Acc ID: GO:0005085
Term: guanyl-nucleotide exchange factor activity
Definition: Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
Definition Source(s): GOC:kd, GOC:mah, PMID:23303910, PMID:27218782
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EIF2B4 ISOEif2b4 (Rattus norvegicus)9068941RGD PMID:9139680 REF_RGD_ID:1581073
EIF2B4contributes_toISOEif2b4 (Rattus norvegicus)9068941RGD PMID:9582312 PMID:9631509 REF_RGD_ID:11041878 REF_RGD_ID:1581075
EIF2B4enablesIEAUniProtKB:Q9UI10 or ensembl:ENSP00000233552150520179Ensembl GO_REF:0000107
EIF2B4contributes_toISOEIF2B4 (Homo sapiens)9068941UniProtKB PMID:11323413

PMID:11323413
EIF2B4contributes_toISOEIF2B4 (Homo sapiens)9068941UniProtKB PMID:15054402

PMID:15054402
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