Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11275
Species: Mus musculus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2decreases expressionEXP 6480464CTDhydroquinone results in decreased expression of CCL2 mRNAPMID:22465845
Ccl2decreases secretionEXP 6480464CTDhydroquinone results in decreased secretion of CCL2 proteinPMID:22465845
Ccl2multiple interactionsEXP 6480464CTDhydroquinone inhibits the reaction [[IFNG protein co-treated with lipopolysaccharide, E. coli O26-B6] results in increased secretion of CCL2 protein]; hydroquinone inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL2 mRNA]; hydroquinone inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL2 protein]; hydroquinone inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of CCL2 protein]PMID:22465845
Ccl2decreases secretionISOCCL2 (Homo sapiens)6480464CTDhydroquinone results in decreased secretion of CCL2 proteinPMID:22302391
Ccl2increases expressionISOCCL2 (Homo sapiens)6480464CTDhydroquinone results in increased expression of CCL2 proteinPMID:17572062
Ccl2increases secretionISOCCL2 (Homo sapiens)6480464CTDhydroquinone results in increased secretion of CCL2 proteinPMID:20946948
Go Back to source page   Continue to Ontology report