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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10652
Species: Mus musculus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcincreases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of GCLC mRNAPMID:35523338
Gclcincreases expressionISOGclc (Rattus norvegicus)6480464CTDDiethylnitrosamine results in increased expression of GCLC mRNAPMID:19638242
Gclcmultiple interactionsISOGclc (Rattus norvegicus)6480464CTD[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLC mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCLC mRNA; [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GCLC mRNAPMID:14656948 PMID:16158176 PMID:28943392
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