GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp7a1 | decreases expression | EXP | | 6480464 | CTD | Lithocholic Acid results in decreased expression of CYP7A1 mRNA | PMID:16436656 PMID:19196849 PMID:20359477 PMID:20671298 PMID:22982774 PMID:23034213 PMID:25582706 | Cyp7a1 | multiple interactions | EXP | | 6480464 | CTD | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]; [Lithocholic Acid results in increased activity of NR1H4 protein] which results in increased expression of CYP7A1 mRNA; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA] | PMID:19196849 PMID:20359477 PMID:22531947 | Cyp7a1 | decreases activity | ISO | Cyp7a1 (Rattus norvegicus) | 6480464 | CTD | Lithocholic Acid results in decreased activity of CYP7A1 protein | PMID:1175606 | Cyp7a1 | decreases expression | ISO | Cyp7a1 (Rattus norvegicus) | 6480464 | CTD | Lithocholic Acid results in decreased expression of CYP7A1 mRNA | PMID:20888898 | Cyp7a1 | decreases expression | ISO | CYP7A1 (Homo sapiens) | 6480464 | CTD | Lithocholic Acid results in decreased expression of CYP7A1 mRNA | PMID:25055961 | Cyp7a1 | multiple interactions | ISO | CYP7A1 (Homo sapiens) | 6480464 | CTD | [Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA | PMID:17963371 | |
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