RGD Annotation Report for impaired smooth muscle contractilityRat Genome Database

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An association has been curated linking Map2k1 and impaired smooth muscle contractility in Rattus norvegicus.

The association was inferred from direct assay (IDA)
The annotation was made from Lagaud GJ, etal., Biochem Biophys Res Commun. 1999 Apr 13;257(2):523-7.
1 additional annotations were made from Lagaud GJ, etal., Biochem Biophys Res Commun. 1999 Apr 13;257(2):523-7.
14 RGD objects have been annotated to impaired smooth muscle contractility (MP:0000740)
67 papers in RGD have been used to annotate Map2k1
Curation Notes: inhibition decreases both calcium-stimulated and unstimulated myogenic tone in middle cerebral arteries (p<0.001)

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.