SHRSP/A3N |
systolic blood pressure |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
arterial blood pressure trait |
male |
203 days-224 days |
10 |
260.0 |
mmHg |
6.0 |
18.97 |
tail cuff plethysmography |
tail |
0.0 |
0 |
|
|
107095 |
3075 |
SHRSP/A3N |
interstitial nephritis foci count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
2.4 |
/section |
0.8 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
foci of interstitial nephritis |
107490 |
3088 |
SHRSP/A3N |
renal fibrosis foci count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
15.0 |
/section |
2.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
foci of renal fibrosis |
107498 |
3088 |
SHRSP/A3N |
heart rate |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
heart pumping trait |
male |
203 days-224 days |
10 |
280.0 |
beats/min |
4.0 |
12.65 |
tail cuff plethysmography |
|
0.0 |
0 |
|
high salt high fat diet +carvedilol |
107116 |
3075 |
SHRSP/A3N |
body weight |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
body mass |
male |
203 days-224 days |
10 |
367.0 |
g |
10.0 |
31.62 |
body weighing method |
|
0.0 |
0 |
|
high salt high fat diet +carvedilol |
107103 |
3075 |
SHRSP/A3N |
end-diastolic volume |
controlled sodium content drinking water (1 %) (between 112 and 126 days) and controlled fat content diet (24.5 %) (between 112 and 126 days) and controlled carvedilol content diet (2400 ppm) (between 112 and 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
cardiac output trait |
male |
189 days-210 days |
0 |
0.96 |
ml |
0.02 |
|
transthoracic echocardiography |
|
0.0 |
0 |
|
high salt high fat diet +carvedilol |
107121 |
3075 |
SHRSP/A3N |
kidney tubule regeneration foci count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
1.9 |
/section |
1.3 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
foci of tubular regeneration |
107486 |
3088 |
SHRSP/A3N |
end-systolic volume |
controlled sodium content drinking water (1 %) (between 112 and 126 days) and controlled fat content diet (24.5 %) (between 112 and 126 days) and controlled carvedilol content diet (2400 ppm) (between 112 and 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
cardiac output trait |
male |
189 days-210 days |
0 |
0.28 |
ml |
0.03 |
|
transthoracic echocardiography |
|
0.0 |
0 |
|
high salt high fat diet +carvedilol |
107125 |
3075 |
SHRSP/A3N |
end-diastolic volume |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) then controlled carvedilol content diet (2400 ppm) (for 42 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
cardiac output trait |
male |
203 days-224 days |
8 |
1.08 |
ml |
0.07 |
0.2 |
transthoracic echocardiography |
|
0.0 |
0 |
|
hsfd +carvedilol reversal |
107134 |
3075 |
SHRSP/A3N |
kidney glomerular lesion count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney glomerulus integrity trait |
male |
210 days-224 days |
0 |
4.0 |
/section |
2.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
|
107478 |
3088 |
SHRSP/A3N |
end-systolic volume |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) then controlled carvedilol content diet (2400 ppm) (for 42 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
cardiac output trait |
male |
203 days-224 days |
8 |
0.36 |
ml |
0.07 |
0.2 |
transthoracic echocardiography |
|
0.0 |
0 |
|
hsfd +carvedilol reversal |
107136 |
3075 |
SHRSP/A3N |
heart rate |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) then controlled carvedilol content diet (2400 ppm) (for 42 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
heart pumping trait |
male |
203 days-224 days |
8 |
236.0 |
beats/min |
8.0 |
22.63 |
transthoracic echocardiography |
|
0.0 |
0 |
|
hsfd +carvedilol reversal |
107138 |
3075 |
SHRSP/A3N |
heart rate |
controlled sodium content drinking water (1 %) (between 112 and 126 days) and controlled fat content diet (24.5 %) (between 112 and 126 days) and controlled carvedilol content diet (2400 ppm) (between 112 and 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
heart pumping trait |
male |
189 days-210 days |
0 |
254.0 |
beats/min |
10.0 |
|
transthoracic echocardiography |
|
0.0 |
0 |
|
high salt high fat diet +carvedilol |
107129 |
3075 |
SHRSP/A3N |
urine total protein excretion rate |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
urine protein amount |
male |
210 days-224 days |
0 |
37.0 |
mg/d |
15.0 |
|
urine protein analysis |
|
86400.0 |
0 |
metabolic cage; sulfosalicylic acid method |
|
107474 |
3088 |
SHRSP/A3N |
ratio of deaths related to left ventricular hypertrophy to total study population during a period of time |
controlled sodium chloride content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. |
total life span |
male |
203 days-224 days |
20 |
0.0 |
% |
|
|
unspecified method |
|
0.0 |
0 |
|
ratio of deaths related to left ventricular hypertrophy to total study population during a period of time (CMO:0003810) |
107112 |
3075 |
SHRSP/A3N |
kidney total tubule cast count |
controlled sodium content drinking water (1 %) (for 126 days) and controlled fat content diet (24.5 %) (for 126 days) and controlled carvedilol content diet (2400 ppm) (for 126 days) |
Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329. |
kidney integrity trait |
male |
210 days-224 days |
0 |
21.0 |
/section |
11.0 |
|
ex vivo light microscopy with histochemistry |
|
0.0 |
0 |
|
total tubular casts |
107494 |
3088 |