GK/MolTac |
Homeostatic Model Assessment of Insulin Resistance |
rosiglitazone (10 mg/kg) (for 23 days) then control condition (for 20 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
122 days-129 days |
4 |
(fasting glucose x fasting insulin)/22.5 |
8.2 |
null |
1.35 |
2.7 |
oral glucose tolerance test |
7200.0 |
0 |
|
103838 |
2864 |
GK/MolTac |
Homeostatic Model Assessment of Insulin Resistance |
sodium chloride solution (for 23 days) then control condition (for 20 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
122 days-129 days |
4 |
(fasting glucose x fasting insulin)/22.5 |
13.0 |
null |
2.65 |
5.3 |
oral glucose tolerance test |
7200.0 |
0 |
|
103836 |
2864 |
GK/MolTac |
blood glucose level |
sodium chloride solution (for 23 days) then control condition (for 20 days) then fasting (for 16 hours) then glucose solution (2 g/kg) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood glucose amount |
male |
122 days-129 days |
4 |
|
162.0 |
mg/dl |
14.0 |
28.0 |
oral glucose tolerance test |
0.0 |
0 |
|
103808 |
2864 |
GK/MolTac |
blood insulin level AUC to blood glucose level AUC ratio |
sodium chloride solution (for 23 days) then control condition (for 20 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
122 days-129 days |
4 |
AUC ins/glu |
0.0 |
null |
0.0 |
0.0 |
oral glucose tolerance test |
7200.0 |
0 |
measured at -5,15,30,45,60,90,120 min |
103822 |
2864 |
GK/MolTac |
blood insulin level AUC to blood glucose level AUC ratio |
rosiglitazone (5 mg/kg) (for 23 days) then control condition (for 20 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
122 days-129 days |
4 |
AUC ins/glu |
0.0 |
null |
0.0 |
0.0 |
oral glucose tolerance test |
7200.0 |
0 |
measured at -5,15,30,45,60,90,120 min |
103823 |
2864 |
GK/MolTac |
blood insulin level AUC to blood glucose level AUC ratio |
rosiglitazone (10 mg/kg) (for 23 days) then control condition (for 20 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
122 days-129 days |
4 |
AUC ins/glu |
0.0 |
null |
0.0 |
0.0 |
oral glucose tolerance test |
7200.0 |
0 |
measured at -5,15,30,45,60,90,120 min |
103824 |
2864 |
GK/MolTac |
whole body insulin sensitivity index |
rosiglitazone (10 mg/kg) (for 23 days) then control condition (for 20 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
122 days-129 days |
4 |
10,000/√(FG x FI) x (Ḡ x Ī) |
2.04 |
null |
0.21 |
0.42 |
oral glucose tolerance test |
7200.0 |
0 |
measured at -5,15,30,45,60,90,120 min |
103831 |
2864 |
GK/MolTac |
whole body insulin sensitivity index |
rosiglitazone (5 mg/kg) (for 23 days) then control condition (for 20 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
122 days-129 days |
4 |
10,000/√(FG x FI) x (Ḡ x Ī) |
1.27 |
null |
0.23 |
0.46 |
oral glucose tolerance test |
7200.0 |
0 |
measured at -5,15,30,45,60,90,120 min |
103830 |
2864 |
GK/MolTac |
Homeostatic Model Assessment of Insulin Resistance |
rosiglitazone (5 mg/kg) (for 23 days) then control condition (for 20 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
122 days-129 days |
4 |
(fasting glucose x fasting insulin)/22.5 |
14.2 |
null |
2.15 |
4.3 |
oral glucose tolerance test |
7200.0 |
0 |
|
103837 |
2864 |
GK/MolTac |
plasma insulin level |
sodium chloride solution (for 23 days) then control condition (for 20 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
122 days-129 days |
4 |
|
37.96 |
mU/l |
6.5 |
13.0 |
oral glucose tolerance test |
0.0 |
0 |
|
103815 |
2864 |
GK/MolTac |
whole body insulin sensitivity index |
sodium chloride solution (for 23 days) then control condition (for 20 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
122 days-129 days |
4 |
10,000/√(FG x FI) x (Ḡ x Ī) |
1.49 |
null |
0.31 |
0.62 |
oral glucose tolerance test |
7200.0 |
0 |
measured at -5,15,30,45,60,90,120 min |
103829 |
2864 |
GK/MolTac |
blood glucose level |
rosiglitazone (10 mg/kg) (for 23 days) then control condition (for 20 days) then fasting (for 16 hours) then glucose solution (2 g/kg) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood glucose amount |
male |
122 days-129 days |
4 |
|
145.0 |
mg/dl |
7.5 |
15.0 |
oral glucose tolerance test |
0.0 |
0 |
|
103810 |
2864 |
GK/MolTac |
blood glucose level |
rosiglitazone (5 mg/kg) (for 23 days) then control condition (for 20 days) then fasting (for 16 hours) then glucose solution (2 g/kg) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood glucose amount |
male |
122 days-129 days |
4 |
|
177.0 |
mg/dl |
5.5 |
11.0 |
oral glucose tolerance test |
0.0 |
0 |
|
103809 |
2864 |
GK/MolTac |
plasma insulin level |
rosiglitazone (5 mg/kg) (for 23 days) then control condition (for 20 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
122 days-129 days |
4 |
|
38.22 |
mU/l |
5.2 |
10.4 |
oral glucose tolerance test |
0.0 |
0 |
|
103816 |
2864 |
GK/MolTac |
plasma insulin level |
rosiglitazone (10 mg/kg) (for 23 days) then control condition (for 20 days) then fasting (for 12 hours) |
Gao W and Jusko WJ, J Pharmacol Exp Ther. 2012 Jun;341(3):617-25. doi: 10.1124/jpet.112.192419. Epub 2012 Feb 29. |
blood insulin amount |
male |
122 days-129 days |
4 |
|
27.3 |
mU/l |
4.16 |
8.32 |
oral glucose tolerance test |
0.0 |
0 |
|
103817 |
2864 |