Phenominer Database Results (10000 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Average Type Value Units SEM SD Method Method Site Method Duration Post Insult Time Value Clinical Measurement Notes Experiment Notes Record ID Study ID
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 20 0.35 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15227 381
SS-Chr 5BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.27 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15228 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 0.3 ml 0.01 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15230 381
SS-Chr 13BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.32 ml 0.05 0.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15240 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 0.42 ml 0.03 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15247 381
FHH-Chr 4BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 0.29 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15251 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.33 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15252 381
SS-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.24 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15258 381
SS-Chr 5BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 118.96 breaths/min 6.82 20.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14792 381
SS-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 101.38 breaths/min 2.9 10.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14821 381
FHH-Chr 15BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 137.56 breaths/min 11.98 37.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14822 381
LEW/Crl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 1 110.79 breaths/min stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14827 381
SS-Chr 17BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 116.32 breaths/min 10.04 34.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14837 381
FHH-Chr 19BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 14 132.99 breaths/min 8.79 32.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14848 381
FHH-Chr 19BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 115.28 breaths/min 3.96 14.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14852 381
FHH-Chr 13BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 122.6 breaths/min 6.9 21.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14854 381
FHH-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 120.68 breaths/min 4.64 14.67 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14859 381
SS-Chr 4BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 106.58 breaths/min 4.02 13.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14866 381
SS-Chr 4BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 106.19 breaths/min 3.92 15.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14870 381
FHH-Chr 9BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 123.37 breaths/min 9.9 31.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14871 381
FHH-Chr 7BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 108.27 breaths/min 5.42 15.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14877 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.41 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14900 381
SS-Chr 9BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 101.36 % 6.02 24.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54024 381
SS-Chr 17BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 110.19 % 4.21 14.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54029 381
SS-Chr 7BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 113.46 % 4.89 15.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54035 381
SS-Chr 16BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 98.7 % 3.92 14.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54040 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 113.11 % 3.26 12.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54054 381
LEW/Crl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 96.64 % 2.34 9.94 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54192 381
FHH-Chr 5BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 161.23 % 13.63 43.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13710 381
FHH-Chr 17BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 148.7 % 11.84 39.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13727 381
SS-Chr 11BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 133.87 % 7.23 22.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13743 381
SS-Chr 11BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 151.8 % 11.61 34.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13746 381
BN/NHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 23 %change=VE during 2-3 min hypoxia/control during standard conditions 141.88 % 3.93 18.84 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13759 381
SS-Chr XBN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 %change=VE during 2-3 min hypoxia/control during standard conditions 133.24 % 4.57 17.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13761 381
SS-Chr 20BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 0.36 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13925 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 13 127.57 mmHg 4.97 17.91 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14372 381
BN/NHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 14 119.99 mmHg 5.02 18.79 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14374 381
FHH-Chr 13BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 9 7.5 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17062 381
SS-Chr 11BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 7.54 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17068 381
SS-Chr YBN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 15 7.51 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17071 381
SS-Chr 18BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 10 7.51 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17073 381
SS-Chr 2BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 7.53 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17088 381
Crl:CD(SD) mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 119.4 mmHg 7.03 18.6 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13878 381
WKY/NCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 15 115.69 mmHg 3.79 14.69 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13883 381
Hsd:SD percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 %change=VE during 2-3 min hypoxia/control during standard conditions 149.54 % 7.3 28.27 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13898 381
FHH-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.26 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13914 381
SS-Chr 20BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 0.42 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13934 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 0.45 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13937 381
SS-Chr 19BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.36 ml 0.04 0.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13943 381
SS-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.28 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13948 381
FHH-Chr 1BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 16 0.33 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13949 381
LEW/Crl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 1 0.35 ml stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13956 381
FHH-Chr 5BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.31 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13959 381
FHH-Chr 14BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.22 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13965 381
GH/OmrMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 0.36 ml 0.04 0.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13968 381
FHH-Chr 19BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 0.33 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13981 381
FHH-Chr 13BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.21 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13983 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 74 0.44 ml 0.01 0.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13991 381
SS-Chr 1BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.35 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13992 381
F344/DuCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 0.25 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14016 381
BN/NHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 138.98 % 6.98 20.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14038 381
FHH-Chr 1BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 8 27.34 mmHg 0.66 1.85 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17289 381
Hsd:SD partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 12 54.19 mmHg 0.97 3.35 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17312 381
WKY/NCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 %change=VE during7-9 min hypoxia/control during standard conditions 147.72 % 9.81 39.24 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17332 381
FHH-Chr 6BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 130.2 % 7.91 26.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13668 381
SS-Chr 15BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 %change=VE during 2-3 min hypoxia/control during standard conditions 135.9 % 9.22 35.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13683 381
SS-Chr 18BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 %change=VE during 2-3 min hypoxia/control during standard conditions 147.4 % 6.9 29.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13697 381
SS-Chr 17BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 3 26.62 mmHg 2.03 3.51 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17228 381
FHH-Chr 16BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 8 27.89 mmHg 0.87 2.47 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17239 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 16 29.09 mmHg 0.6 2.4 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17261 381
SS-Chr YBN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 15 26.5 mmHg 0.57 2.22 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17263 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 53 27.33 mmHg 0.43 3.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17266 381
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 7 29.55 mmHg 1.0 2.64 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17269 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 9 28.49 mmHg 0.62 1.85 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17271 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 8 31.77 mmHg 0.93 2.64 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17285 381
SS-Chr XBN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 6 26.08 mmHg 1.19 2.92 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17286 381
BN/NHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 %change=VE during 2-3 min hypoxia/control during standard conditions 144.23 % 11.49 32.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14039 381
WKY/NCruk heart right ventricle wet weight controlled air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 heart right ventricle mass male 105 days 28 median 0.42 g post excision weight measurement 0 11575 102
FHH-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 120.14 % 7.05 22.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53743 381
FHH-Chr 10BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 111.14 % 6.59 20.85 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53744 381
GH/OmrMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 6 123.82 % 16.01 39.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53752 381
SS-Chr 15BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 129.4 % 8.48 32.85 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53757 381
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 117.75 % 4.28 18.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53773 381
SS-Chr 6BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 17 127.46 % 5.16 21.28 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53787 381
FHH-Chr 5BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 129.11 % 14.01 44.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53789 381
SS-Chr 10BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 139.42 % 9.16 28.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53794 381
FHH-Chr 16BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 141.61 % 10.6 39.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53797 381
FHH-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 108.37 % 6.65 21.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53806 381
SS-Chr 16BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 120.02 % 3.82 13.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53811 381
FHH-Chr 13BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 124.13 % 7.94 25.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53812 381
FHH-Chr 13BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 119.25 % 5.26 17.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53813 381
SS-Chr 1BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 109.27 % 7.24 22.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53820 381
FHH-Chr 7BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 124.01 % 12.71 42.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53830 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 74 130.38 % 3.9 33.51 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53831 381
SS-Chr 20BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 105.43 % 4.25 15.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54000 381
FHH-Chr 1BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 16 106.0 % 4.38 17.51 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54013 381
SS-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 110.22 % 4.16 15.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54014 381
Hsd:SD body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 5 37.68 degrees C 0.32 0.73 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19990 381
LE/BluGill body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.85 degrees C 0.11 0.35 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19995 381
WKY/NCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 11 -6.02 mmHg 0.58 1.94 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20979 381
Hsd:SD absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 1 -6.5 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20980 381
LE/BluGill absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 -6.29 mmHg 0.59 1.56 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20985 381
FHH-Chr 10BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 104.26 % 3.59 11.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53876 381
FHH-Chr XBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 94.33 % 3.25 10.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53885 381
FHH-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 104.39 % 3.28 10.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53898 381
FHH-Chr 1BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 18 115.65 % 4.49 19.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53903 381
SS-Chr 19BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 108.93 % 6.8 20.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53909 381
FHH-Chr 15BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 113.26 % 6.71 21.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53914 381
SS-Chr 9BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 130.33 % 3.39 10.71 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53920 381
SS-Chr 9BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 111.46 % 5.96 24.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53923 381
SS-Chr 10BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 115.75 % 4.77 15.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53926 381
FHH-Chr 17BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 118.27 % 9.17 30.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53931 381
SS-Chr 7BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 121.46 % 3.4 10.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53934 381
SS-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 109.67 % 6.85 22.71 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53946 381
SS-Chr 11BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 112.88 % 3.86 11.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53949 381
FHH-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 97.92 % 3.21 13.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53969 381
SS-Chr 5BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 105.11 % 6.89 21.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53979 381
FHH-Chr XBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 91.36 % 5.26 16.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53980 381
FHH-Chr 20BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 112.34 % 8.03 24.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53993 381
FHH-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 109.35 % 8.6 24.33 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53995 381
WKY/NCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 49.48 ml/min 1.51 6.04 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19715 381
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 69.69 ml/min 4.23 9.46 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19716 381
Crl:CD(SD) minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 54.74 ml/min 3.92 14.14 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19718 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19764 381
SS-Chr 17BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 0.01 null 0.03 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19770 381
GH/OmrMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 3 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19773 381
SHR/NCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 11 0.08 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19781 381
SS-Chr 16BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 4 7.47 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20115 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 46.57 ml/min 3.14 10.4 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20122 381
GH/OmrMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 49.29 ml/min 3.53 9.34 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20128 381
FHH-Chr 19BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19792 381
FHH-Chr 11BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 2 0.05 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19817 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 0.05 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19818 381
Hsd:SD absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 7 0.08 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20696 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 57.86 ml/min 2.51 7.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20700 381
SS-Chr 16BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 50.2 ml/min 4.92 13.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20701 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 44.55 ml/min 4.31 13.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20708 381
SS-Chr XBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 120.38 breaths/min 7.0 24.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18335 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 123.35 breaths/min 5.49 19.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18338 381
FHH-Chr 9BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 144.6 breaths/min 8.25 24.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18347 381
SS/JrHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 %change=VE during7-9 min hypoxia/control during standard conditions 133.12 % 9.95 26.33 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18374 381
SS-Chr 16BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 41.5 ml/min 2.06 7.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18718 381
SS-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 43.24 ml/min 4.31 14.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18719 381
FHH-Chr 13BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 28.48 ml/min 3.06 9.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18722 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 49 39.71 ml/min 1.83 12.81 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18726 381
SS/JrHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 5 0.05 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18784 381
SS/JrHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18790 381
GH/OmrMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 7 0.05 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18791 381
FHH-Chr 3BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 289.75 U/l 15.64 44.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36433 401
SS-Chr 3BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 7 251.29 U/l 14.1 37.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36435 401
FHH-Chr 19BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 302.5 U/l 16.31 51.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36436 401
SS-Chr 16BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 14 195.29 U/l 8.49 31.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36437 401
SS-Chr 3BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 6 199.17 U/l 29.69 72.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36440 401
SS-Chr 11BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 17 123.12 U/l 4.68 19.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36441 401
SS-Chr 1BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 6 290.17 U/l 12.78 31.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36447 401
FHH-Chr 11BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 275.88 U/l 7.88 22.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36453 401
FHH-Chr 7BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 200.9 U/l 4.51 14.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36456 401
LEW/Crl serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 68.7 mg/dl 2.8 8.86 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36468 401
SHR/NCrl serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 17 5.94 g/dl 0.06 0.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36959 401
FHH-Chr XBN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 7 4.61 g/dl 0.06 0.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36962 401
SS-Chr 13BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 12 6.57 g/dl 0.04 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36969 401
Hsd:SD absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 7 -8.6 mmHg 1.68 4.44 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18817 381
LEW/Crl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 36.34 ml/min 2.57 10.89 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18963 381
SS-Chr 16BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 5 59.02 mmHg 2.66 5.94 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18976 381
F344/DuCrl serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 18 5.94 g/dl 0.08 0.36 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36264 401
Crl:CD(SD) serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 9 6.77 g/dl 0.14 0.43 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36265 401
F344/DuCrl serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 17 5.99 g/dl 0.08 0.33 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36269 401
FHH-Chr YBN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 9 5.24 g/dl 0.06 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36975 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 9 6.4 g/dl 0.06 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36981 401
SS-Chr 6BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 9 6.36 g/dl 0.07 0.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36995 401
FHH-Chr 5BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 5.16 g/dl 0.1 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36997 401
FHH-Chr 17BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 6 5.23 g/dl 0.04 0.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37008 401
SS-Chr 17BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 5.59 g/dl 0.07 0.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37009 401
GH/OmrMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 18 6.22 g/dl 0.07 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37011 401
SS-Chr 7BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 12 6.16 g/dl 0.1 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37012 401
FHH-Chr 19BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.25 g/dl 0.09 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37015 401
SS-Chr XBN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 11 5.49 g/dl 0.07 0.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37031 401
FHH-Chr 11BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 4.74 g/dl 0.12 0.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37036 401
FHH-Chr 7BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.28 g/dl 0.12 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37044 401
SS-Chr 16BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 6 18.33 mmol/l 0.56 1.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37047 401
FHH/EurMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 7 19.43 mmol/l 2.07 5.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37049 401
FHH/EurMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 18.83 pg 0.09 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 37075 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 14 92.5 mg/dl 2.53 9.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37083 401
FHH-Chr 12BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 11 81.45 mg/dl 2.51 8.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37088 401
SS-Chr 15BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 77.9 mg/dl 3.39 10.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37100 401
FHH-Chr 20BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 69.2 mg/dl 1.37 4.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37103 401
FHH-Chr 20BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 66.4 mg/dl 1.53 4.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37106 401
SS-Chr 19BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 98.6 mg/dl 8.06 25.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37119 401
FHH-Chr 15BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 77.5 mg/dl 2.09 5.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37125 401
FHH-Chr 15BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 69.88 mg/dl 2.78 7.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37136 401
SS-Chr 17BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 70.13 mg/dl 2.77 7.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37144 401
FHH-Chr 3BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 65.88 mg/dl 2.87 8.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37151 401
FHH-Chr 19BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 67.7 mg/dl 1.32 4.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37154 401
SS-Chr 11BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 17 76.18 mg/dl 3.38 13.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37159 401
FHH-Chr 7BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 76.7 mg/dl 2.69 8.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37174 401
Hsd:SD partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 7 28.14 mmHg 1.03 2.73 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17016 381
SHR/NCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.53 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17040 381
SS-Chr 20BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 10 7.52 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17049 381
FHH/EurMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 10 7.51 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17051 381
SS-Chr 16BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 10 7.51 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17052 381
FHH-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 170.83 breaths/min 10.04 31.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18320 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 74 128.62 breaths/min 2.85 24.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18333 381
LEW/Crl mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 59.08 fl 0.3 0.94 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36291 401
LE/BluGill mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 59.45 fl 0.72 2.27 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36294 401
FHH-Chr 12BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 12 286.33 U/l 7.3 25.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36364 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 114.0 U/l 8.91 28.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36369 401
FHH-Chr 12BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 11 412.27 U/l 8.23 27.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36370 401
FHH-Chr 8BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 299.5 U/l 10.57 33.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36380 401
SS-Chr 13BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 11 209.64 U/l 9.25 30.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36391 401
FHH-Chr 4BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 7 207.14 U/l 8.44 22.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36397 401
FHH-Chr 5BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 317.13 U/l 15.95 45.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36409 401
SS-Chr 14BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 17 117.94 U/l 4.39 18.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36411 401
SS-Chr 9BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 18 170.11 U/l 11.37 48.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36416 401
SS-Chr 10BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 156.4 U/l 14.78 46.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36419 401
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 144.25 breaths/min 8.62 27.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15372 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 107.96 breaths/min 5.4 16.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15378 381
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 4 105.83 mmHg 7.4 14.81 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14414 381
SS-Chr 14BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.34 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15270 381
FHH-Chr 16BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 0.28 ml 0.02 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15277 381
FHH-Chr 17BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.23 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15282 381
FHH-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.2 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15288 381
SS-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.35 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15290 381
FHH-Chr 13BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.19 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15293 381
FHH-Chr 13BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.25 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15294 381
SS-Chr XBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 0.26 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15314 381
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 130.27 mmHg 2.33 6.17 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14666 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 9 122.02 mmHg 7.52 22.57 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14670 381
SS-Chr 16BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 0.31 ml 0.03 0.07 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14622 381
FHH-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 129.58 breaths/min 4.82 15.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14785 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 20 167.82 breaths/min 5.97 26.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14788 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 %change=VE during 2-3 min hypoxia/control during standard conditions 152.04 % 5.31 20.57 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13666 381
SS-Chr 16BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 6 -0.18 degrees C 0.29 0.7 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14132 381
FHH-Chr 12BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 17 122.37 mmHg 3.52 14.5 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14302 381
FHH-Chr 6BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 1 80.22 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14310 381
SS-Chr 9BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 11 117.91 mmHg 4.08 13.54 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14312 381
SS-Chr 17BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 8 123.12 mmHg 4.97 14.04 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14316 381
SS-Chr 5BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 4 124.62 mmHg 13.43 26.85 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14323 381
SS-Chr 3BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 5 140.79 mmHg 7.38 16.49 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14342 381
SS-Chr 13BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 8 120.5 mmHg 4.3 12.17 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14352 381
SS/JrHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 10 7.51 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17605 381
FHH/EurMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 7.5 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17606 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 116.03 breaths/min 8.65 24.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17691 381
SS-Chr 16BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 -8.0 mmHg 0.25 0.6 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17712 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 -7.59 mmHg 1.29 3.64 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17713 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 4 -10.59 mmHg 0.49 0.99 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17717 381
SS-Chr 16BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 6 37.97 degrees C 0.18 0.44 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17720 381
SS/JrHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 7 37.89 degrees C 0.14 0.38 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17724 381
SS-Chr 16BN/Mcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 %change=VE during7-9 min hypoxia/control during standard conditions 167.62 % 15.92 42.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17915 381
SHR/NCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during7-9 min hypoxia/control during standard conditions 130.1 % 7.9 23.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17916 381
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 121.58 breaths/min 8.14 31.52 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17932 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 -45.24 mmHg 2.31 5.65 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17939 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 -50.89 mmHg 2.79 7.89 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17941 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 -49.62 mmHg 2.89 8.19 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17944 381
Crl:CD(SD) absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 5 -44.6 mmHg 4.41 9.85 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20688 381
F344/DuCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 -51.37 mmHg 4.19 11.86 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20689 381
SHR/NCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 55.37 mmHg 2.15 5.69 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19552 381
SS-Chr 16BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 52.43 mmHg 1.54 3.76 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19554 381
SS-Chr 6BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 11 -5.27 mmHg 0.85 2.82 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19612 381
SS-Chr 7BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 7 -5.06 mmHg 0.33 0.88 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19622 381
SS-Chr 7BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 -6.71 mmHg 1.27 3.35 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19628 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 58.76 ml/min 2.75 8.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18068 381
Crl:CD(SD) blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 5 7.49 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18092 381
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 6 467.49 beats/min 17.12 41.93 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18100 381
SS-Chr YBN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 13 -4.81 mmHg 0.84 3.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19655 381
FHH-Chr 1BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 9 -6.23 mmHg 0.45 1.35 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19660 381
SS-Chr 19BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 3 -6.83 mmHg 2.08 3.61 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19667 381
FHH-Chr 1BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 -5.77 mmHg 0.62 1.65 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19681 381
Hsd:SD serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 18 123.06 U/l 9.73 41.27 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37280 401
SS/JrHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 4 9.68 mg/dl 0.06 0.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37292 401
SS-Chr 20BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 16.63 mmol/l 1.52 4.31 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36585 401
Hsd:SD serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 16 17.38 mmol/l 0.64 2.55 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36587 401
Hsd:SD serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 16 141.94 mmol/l 0.48 1.91 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36593 401
FHH-Chr 2BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.21 mg/dl 0.17 0.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36611 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.57 mg/dl 0.1 0.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36614 401
FHH-Chr 10BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.13 mg/dl 0.09 0.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36617 401
SHR/NCrl serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 20 9.14 mg/dl 0.06 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36618 401
FHH-Chr XBN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.31 mg/dl 0.14 0.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36620 401
FHH-Chr 8BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.36 mg/dl 0.14 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36625 401
FHH/EurMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 -41.67 mmHg 7.22 12.51 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18644 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 -44.58 mmHg 2.78 6.81 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18645 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 49.27 ml/min 2.43 8.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18652 381
FHH-Chr 8BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 39.56 ml/min 3.23 10.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18663 381
SS-Chr 13BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 43.89 ml/min 6.71 20.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18674 381
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 51.51 ml/min 2.48 9.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18676 381
SS-Chr 19BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 44.02 ml/min 6.34 19.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18684 381
Crl:CD(SD) serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 9 93.22 U/l 8.4 25.2 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37426 401
LE/BluGill serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 141.88 U/l 13.0 36.76 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37431 401
SS-Chr 7BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 45.09 ml/min 5.7 17.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18708 381
FHH-Chr 17BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 38.7 ml/min 3.2 10.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18709 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 434.17 beats/min 16.01 45.28 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17482 381
SS-Chr 17BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 8 425.92 beats/min 18.65 52.74 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17489 381
SS-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 399.96 beats/min 16.39 49.18 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17491 381
FHH-Chr 17BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 418.05 beats/min 9.42 26.66 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17497 381
FHH-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 443.8 beats/min 11.46 34.39 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17502 381
FHH-Chr 8BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 394.45 beats/min 17.93 50.71 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17503 381
FHH-Chr 19BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 10 434.94 beats/min 9.88 31.24 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17505 381
SS-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 12 441.23 beats/min 11.82 40.96 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17507 381
SS-Chr 15BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 4 397.64 beats/min 9.71 19.43 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17508 381
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 5 400.21 beats/min 26.78 59.88 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17509 381
FHH-Chr 8BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 6 395.92 beats/min 8.61 21.1 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17514 381
FHH-Chr 20BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 5 358.54 beats/min 27.09 60.58 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17516 381
SS-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 8 417.99 beats/min 12.93 36.58 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17525 381
SS-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 5 465.07 beats/min 23.98 53.62 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17539 381
SS-Chr 19BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 1 408.35 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17542 381
FHH-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 3 428.88 beats/min 19.96 34.57 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17550 381
WKY/NCrl serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 9 90.89 mg/dl 2.32 6.95 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36469 401
FHH-Chr 15BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 8.96 mg/dl 0.14 0.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36652 401
SS-Chr 10BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.51 mg/dl 0.11 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36664 401
SS-Chr 7BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 11 9.65 mg/dl 0.14 0.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36669 401
SS-Chr 7BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 12 9.53 mg/dl 0.09 0.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36674 401
SS-Chr 16BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 13 8.93 mg/dl 0.12 0.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36682 401
FHH-Chr 3BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.5 mg/dl 0.38 1.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36688 401
SS-Chr YBN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 20 9.58 mg/dl 0.08 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36690 401
FHH-Chr 11BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.44 mg/dl 0.14 0.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36698 401
SS-Chr 4BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 29 9.41 mg/dl 0.07 0.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36699 401
BN/NHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 20 8.97 mg/dl 0.12 0.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36702 401
SS/JrHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 4 119.25 mg/dl 15.65 31.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36707 401
SS-Chr 16BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 7 92.29 mg/dl 2.52 6.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36710 401
F344/DuCrl serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 17 9.85 mg/dl 0.26 1.07 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36723 401
LE/BluGill serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 7.99 mg/dl 0.32 1.01 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36724 401
Hsd:SD serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 18 9.51 mg/dl 0.06 0.27 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36731 401
SS-Chr 16BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 7 178.86 U/l 9.57 25.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36736 401
FHH/EurMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 7 408.57 U/l 19.44 51.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36737 401
Hsd:SD serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 3 9.43 mg/dl 1.51 2.61 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36838 401
Hsd:SD plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 5 25.0 mmol/l 0.84 1.87 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36844 401
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 141.81 breaths/min 13.13 45.47 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18151 381
GH/OmrMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 133.26 breaths/min 6.22 16.45 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18153 381
Hsd:SD absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 5 0.34 degrees C 0.25 0.56 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19154 381
WKY/NCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 9 19.49 % 9.73 29.2 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49028 461
GH/OmrMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 7 27.35 mmHg 0.59 1.55 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18172 381
WKY/NCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 20 158.6 breaths/min 5.09 22.75 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18213 381
F344/DuCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 130.93 breaths/min 5.56 23.59 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18214 381
FHH/EurMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 37.02 degrees C 0.1 0.3 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18230 381
FHH/EurMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 8 36.63 degrees C 0.18 0.52 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18235 381
SS/JrHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 37.72 degrees C 0.09 0.26 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18238 381
FHH-Chr 6BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 137.49 breaths/min 6.39 21.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18253 381
FHH-Chr 6BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 133.08 breaths/min 14.51 38.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18254 381
FHH-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 129.06 breaths/min 5.06 16.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18256 381
SS-Chr 5BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 130.2 breaths/min 13.87 41.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18263 381
FHH-Chr 8BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 140.13 breaths/min 7.45 24.71 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18266 381
SS-Chr 15BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 144.03 breaths/min 6.13 23.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18268 381
SS-Chr 15BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 114.3 breaths/min 6.96 22.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18269 381
FHH-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 123.21 breaths/min 5.35 17.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18275 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 115.55 breaths/min 4.5 18.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18279 381
FHH-Chr 1BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 18 129.74 breaths/min 5.56 23.59 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18280 381
FHH-Chr 4BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 169.99 breaths/min 11.73 42.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18281 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 118.35 breaths/min 4.53 19.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18282 381
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 44.08 ml/min 2.32 9.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20222 381
FHH-Chr 4BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 43.66 ml/min 4.6 16.59 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20224 381
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 40.41 ml/min 2.93 12.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20225 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 33.23 ml/min 1.79 5.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20227 381
FHH-Chr 14BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 29.87 ml/min 3.14 9.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20239 381
SS-Chr 6BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 55.06 ml/min 2.74 9.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20247 381
GH/OmrMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 46.46 ml/min 4.8 12.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20253 381
FHH-Chr 19BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 36.73 ml/min 2.06 7.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20262 381
SS-Chr 16BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 48.44 ml/min 2.58 9.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20267 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 49 37.21 ml/min 1.74 12.15 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20272 381
SS-Chr XBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 24.6 ml/min 2.72 9.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20278 381
FHH-Chr 2BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.29 degrees C 0.12 0.37 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20296 381
FHH-Chr 12BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 -0.34 degrees C 0.11 0.36 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20300 381
FHH-Chr XBN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 0.44 degrees C 0.17 0.54 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20305 381
SS-Chr 16BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 10 -40.91 mmHg 2.64 8.34 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19467 381
FHH-Chr 19BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 -42.84 mmHg 3.12 7.63 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19471 381
FHH-Chr 8BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 -44.8 mmHg 2.08 5.09 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19474 381
FHH-Chr 13BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 10 -39.21 mmHg 2.0 6.31 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19477 381
SS-Chr 13BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 -48.86 mmHg 3.58 9.48 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19478 381
SS-Chr YBN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 13 -50.18 mmHg 1.58 5.7 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19486 381
SS-Chr 11BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 -47.97 mmHg 3.08 7.53 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19487 381
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 37.43 ml/min 1.6 6.19 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19298 381
SS-Chr 16BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 5 -3.52 mmHg 1.58 3.54 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19331 381
FHH-Chr 6BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 1 -32.7 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19439 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 -40.93 mmHg 3.13 9.38 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19443 381
FHH-Chr 17BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 -41.44 mmHg 2.97 8.41 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19457 381
SHR/NCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 11 -44.75 mmHg 2.02 6.69 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19460 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 10 53.17 mmHg 1.44 4.55 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20449 381
SS-Chr 7BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 7 55.41 mmHg 1.35 3.57 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20463 381
SS-Chr 16BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 9 54.63 mmHg 1.6 4.81 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20484 381
SS/JrHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 55 54.51 mmHg 0.72 5.33 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20501 381
SS-Chr XBN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 4 66.43 mmHg 3.21 6.42 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20502 381
SS/JrHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 52.83 mmHg 1.57 4.7 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20506 381
SS-Chr 4BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 60.22 mmHg 2.24 6.33 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20513 381
FHH-Chr 7BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 3 51.7 mmHg 1.25 2.17 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20515 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 58.59 mmHg 1.63 4.61 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20517 381
SS-Chr 18BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 0.06 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20537 381
SHR/NCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.08 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20541 381
SHR/NCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 0.07 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20548 381
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 1 107.0 mmHg balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49156 461
Hsd:SD heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 13 49.58 mmHg 4.1 14.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49160 461
SS-Chr 15BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 -0.37 degrees C 0.26 0.84 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20313 381
SS-Chr 19BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 8 -0.04 degrees C 0.22 0.61 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20329 381
SS-Chr 12BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 8 -0.67 degrees C 0.62 1.77 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20334 381
FHH-Chr 14BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.16 degrees C 0.16 0.51 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20340 381
FHH-Chr 5BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 0.32 degrees C 0.17 0.54 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20345 381
SS-Chr 14BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 0.43 degrees C 0.14 0.5 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20346 381
SS-Chr 6BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 0.02 degrees C 0.2 0.73 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20348 381
GH/OmrMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 7 -0.17 degrees C 0.23 0.6 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20354 381
SS-Chr 7BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 -0.03 degrees C 0.14 0.42 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20355 381
FHH-Chr 17BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.09 degrees C 0.24 0.77 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20358 381
SS-Chr 7BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 -0.46 degrees C 0.22 0.71 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20360 381
SS-Chr 11BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 -0.21 degrees C 0.19 0.59 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20372 381
SS-Chr YBN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 19 0.19 degrees C 0.16 0.71 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20376 381
Hsd:SD percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 3 post-ischemic value/pre-ischemic value x 100% 58.59 % 29.76 51.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49269 461
LE/BluGill percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 89.79 % 5.16 15.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49271 461
LEW/Crl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 107.36 mmHg 4.55 14.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49273 461
SHR/NCrl time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 16 562.96 s 69.18 276.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49296 461
FHH-Chr 10BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 909.22 s 50.21 150.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49298 461
FHH-Chr 18BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 864.67 s 36.4 109.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49307 461
SS-Chr 18BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 859.0 s 74.01 222.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49313 461
FHH-Chr 4BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 1000.38 s 34.08 96.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49315 461
SS-Chr 19BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 877.0 s 22.7 68.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49319 461
SS-Chr 19BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 860.7 s 38.26 120.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49321 461
FHH-Chr 14BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 6 965.13 s 35.13 86.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49340 461
SS-Chr 17BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 937.22 s 59.21 177.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49346 461
FHH/EurMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 15 1006.31 s 59.16 229.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49350 461
FHH/EurMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 48 978.1 s 33.1 229.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49361 461
SS-Chr XBN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 931.7 s 32.04 101.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49367 461
BN/NHsdMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 23 931.69 s 37.66 180.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49377 461
LE/BluGill body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 11 152.2 g 7.2 23.8 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50084 461
SS-Chr 18BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 1094.56 s 28.28 79.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50100 461
FHH-Chr 6BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 1041.0 s 41.79 118.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50216 461
FHH-Chr XBN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 1275.25 s 46.44 131.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50223 461
SHR/NCrl time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 16 1059.06 s 51.85 207.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50224 461
Crl:CD(SD) heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 47.1 mmHg 2.59 8.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49591 461
LE/BluGill heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 11 31.45 mmHg 4.09 13.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49593 461
F344/DuCrl heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 29.9 mmHg 3.66 11.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49597 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 3 0.31 IU/g 0.07 0.12 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49622 461
SS-Chr 16BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 12 15.01 % 2.6 9.0 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 49629 461
FHH/EurMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 7 10.42 % 3.58 9.47 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 49632 461
LEW/Crl percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 69.31 % 3.71 11.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49652 461
F344/DuCrl percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 71.26 % 12.9 38.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49661 461
FHH-Chr 10BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 3 5.22 % 2.0 3.46 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49691 461
SHR/NCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 15 23.17 % 3.42 13.24 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49695 461
FHH-Chr 8BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 7.38 % 4.16 13.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49703 461
FHH-Chr 1BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 10.78 % 4.5 14.23 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49713 461
SS-Chr 9BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 18 25.81 % 5.45 23.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49732 461
FHH-Chr 14BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 5 3.86 % 0.78 1.75 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49739 461
FHH-Chr 13BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 6.43 % 2.58 8.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49757 461
SS-Chr 11BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 20 14.65 % 2.14 9.58 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49759 461
SS-Chr 1BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 8 23.74 % 3.83 10.83 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49765 461
SS-Chr XBN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 18.28 % 2.57 7.7 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49766 461
BN/NHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 24 6.26 % 2.01 9.87 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49775 461
Crl:CD(SD) left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 136.65 mmHg 5.53 17.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49802 461
WKY/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 152.7 mmHg 5.6 17.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49808 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 62.2 mmHg 6.18 13.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49819 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 349.14 beats/min 30.12 85.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49848 461
FHH-Chr 10BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 72.99 mmHg 13.33 26.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49881 461
SS-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 18 103.76 mmHg 5.25 22.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49895 461
FHH-Chr 1BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 94.47 mmHg 5.26 15.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49903 461
SS-Chr 9BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 17 1006.44 s 32.97 135.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50264 461
SS-Chr 7BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 1134.7 s 93.78 311.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50272 461
FHH-Chr 16BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 20 1161.1 s 32.42 144.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50277 461
FHH-Chr 19BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1171.9 s 80.31 253.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50283 461
SS-Chr 11BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 24 1082.46 s 23.47 114.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50291 461
FHH-Chr 11BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 6 1162.83 s 30.3 74.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50300 461
FHH-Chr 4BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 82.06 mmHg 6.08 19.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49906 461
FHH-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 82.27 mmHg 5.37 15.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49918 461
SS-Chr 9BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 16 105.78 mmHg 2.59 10.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49922 461
SS-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 19 93.45 mmHg 5.56 24.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49924 461
SS-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 96.23 mmHg 6.58 21.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49933 461
SS-Chr 17BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 95.03 mmHg 5.38 16.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49935 461
SS-Chr 4BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 17 97.79 mmHg 4.83 19.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49958 461
WKY/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 237.54 beats/min 7.97 23.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49970 461
FHH-Chr 2BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 29.38 mmHg 2.53 7.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49989 461
FHH-Chr 20BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 38.44 mmHg 2.69 8.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50006 461
FHH-Chr 1BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 43.4 mmHg 3.35 10.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50012 461
SS-Chr 12BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 30.8 mmHg 2.58 8.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50022 461
SS-Chr 14BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 16 38.69 mmHg 4.18 16.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50029 461
SS-Chr 14BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 19 39.42 mmHg 3.16 13.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50033 461
FHH-Chr 15BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 23.88 mmHg 2.21 6.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50036 461
FHH-Chr 3BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 5 29.6 mmHg 6.54 14.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50050 461
SS-Chr 10BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 169.0 g 6.5 20.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49493 461
FHH-Chr 14BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 9 84.3 g 7.4 22.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49495 461
SS-Chr 9BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 137.3 g 2.5 8.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49506 461
FHH-Chr 10BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 66.5 g 3.5 11.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49514 461
SS-Chr 5BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 176.0 g 3.0 9.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49525 461
SS-Chr 20BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 15 164.2 g 5.7 22.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49548 461
SS-Chr 19BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 179.6 g 6.4 20.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49570 461
SS-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 141.8 g 3.5 11.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49579 461
BN/NHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 23 115.0 g 2.4 11.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49581 461
SS-Chr 14BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 20 3.39 g/dl 0.05 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42269 401
SS-Chr 6BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.7 g/dl 0.08 0.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42271 401
SS-Chr 7BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 11 3.64 g/dl 0.11 0.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42278 401
FHH/EurMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 18 3.61 g/dl 0.07 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42285 401
SS-Chr YBN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 20 3.81 g/dl 0.03 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42299 401
SS-Chr 4BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 29 4.02 g/dl 0.04 0.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42308 401
SS-Chr XBN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.21 g/dl 0.05 0.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42313 401
FHH-Chr 9BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 7 3.13 g/dl 0.09 0.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42314 401
SS/JrHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 4 9.23 mg/dl 0.51 1.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42316 401
SS-Chr 16BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 7 8.93 mg/dl 0.2 0.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42319 401
Hsd:SD serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 3 3.5 g/dl 0.5 0.87 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42337 401
Hsd:SD serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 5 20.4 mmol/l 1.12 2.51 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42338 401
LE/BluGill serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 337.9 U/l 21.04 66.53 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42355 401
WKY/NCrl blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 9 0.84 x 1000 cells/ul 0.09 0.27 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42373 401
SS/JrHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 4 3.33 g/dl 0.15 0.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42393 401
SS/JrHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 7 3.79 g/dl 0.09 0.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42398 401
SS-Chr 7BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 12 16.5 mmol/l 0.96 3.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42112 401
SS/JrHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 77.9 U/l 6.31 19.95 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42174 401
SS-Chr 16BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 7 6.34 g/dl 0.08 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42193 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 4.03 g/dl 0.06 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42223 401
SS-Chr 5BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 7 3.64 g/dl 0.04 0.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42231 401
SS-Chr 15BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.88 g/dl 0.07 0.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42237 401
FHH-Chr 20BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 4.02 g/dl 0.03 0.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42239 401
FHH-Chr 18BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.82 g/dl 0.04 0.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42241 401
SS-Chr 13BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 11 3.95 g/dl 0.03 0.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42245 401
SS-Chr 13BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 11 57.16 % 1.1 3.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39003 401
SS-Chr 19BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 56.92 % 0.69 2.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39011 401
SS-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 57.17 % 0.47 1.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39014 401
SS-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 15 58.69 % 0.92 3.58 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39018 401
SS-Chr 14BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 20 52.83 % 0.8 3.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39027 401
SS-Chr 15BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 63.51 fl 0.56 1.77 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38748 401
SS-Chr 15BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 65.05 fl 0.28 0.8 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38749 401
FHH-Chr 18BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 58.85 fl 0.29 0.93 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38755 401
SS-Chr 20BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 33 60.29 fl 0.27 1.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38756 401
FHH-Chr YBN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 9 59.94 fl 0.28 0.84 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38758 401
SS-Chr 12BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 62.45 fl 0.5 1.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38766 401
SS-Chr 10BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 60.65 fl 0.53 1.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38774 401
FHH-Chr 15BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 58.56 fl 0.8 2.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38784 401
GH/OmrMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 16 61.01 fl 0.31 1.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38794 401
FHH/EurMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 16 57.06 fl 0.28 1.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38797 401
SS/JrHsdMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 62.51 fl 0.17 0.54 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38817 401
BN/NHsdMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 13 56.81 fl 0.18 0.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38824 401
Hsd:SD serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 5 6.22 mmol/l 0.2 0.46 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38860 401
SS-Chr 5BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 22.38 mmol/l 0.73 2.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42057 401
SHR/NCrl serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 17 15.94 mmol/l 1.06 4.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42059 401
SS-Chr 15BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 18.4 mmol/l 1.19 3.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42065 401
FHH-Chr 8BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 20.4 mmol/l 0.87 2.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42067 401
SS-Chr 18BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 18.5 mmol/l 0.68 1.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42076 401
FHH-Chr 1BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 15 14.93 mmol/l 0.48 1.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42077 401
SS-Chr 2BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 16.0 mmol/l 0.61 1.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42085 401
FHH-Chr 15BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 21.38 mmol/l 1.13 3.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42090 401
FHH-Chr 15BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 21.5 mmol/l 0.78 2.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42101 401
GH/OmrMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 15 14.07 mmol/l 0.63 2.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42106 401
SS-Chr 7BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 12 53.23 % 0.59 2.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39041 401
SS-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 7 48.07 % 1.54 4.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39052 401
FHH-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 51.36 % 1.44 4.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39055 401
SS-Chr YBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 20 61.58 % 0.71 3.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39057 401
SS-Chr 1BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 6 56.48 % 0.7 1.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39059 401
SS-Chr 4BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 27 55.27 % 0.53 2.76 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39062 401
FHH/EurMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 7 22.0 mmol/l 0.98 2.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39087 401
FHH/EurMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 7 18.71 mmol/l 1.6 4.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39090 401
F344/DuCrl serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 17 4.4 mmol/l 0.11 0.47 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39100 401
FHH-Chr 2BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 108.0 mmol/l 0.82 2.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39104 401
FHH-Chr 6BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 109.2 mmol/l 0.42 1.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39106 401
SHR/NCrl serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 20 106.9 mmol/l 0.35 1.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39111 401
FHH-Chr XBN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 7 110.14 mmol/l 0.83 2.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39117 401
FHH-Chr 8BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 106.6 mmol/l 0.72 2.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39118 401
SS-Chr 18BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 9 104.11 mmol/l 0.77 2.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39134 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 11 3.99 g/dl 0.05 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42257 401
FHH-Chr 1BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 9 3.78 g/dl 0.04 0.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42259 401
SS-Chr 5BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 7 62.46 fl 0.47 1.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38743 401
SS-Chr 20BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 26 62.46 fl 0.27 1.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38747 401
SS-Chr 17BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 143.63 mmol/l 0.96 2.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39435 401
SS-Chr 7BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 12 142.42 mmol/l 0.31 1.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39438 401
FHH-Chr 19BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 142.7 mmol/l 0.4 1.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39445 401
SS-Chr 3BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 6 144.5 mmol/l 1.09 2.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39449 401
FHH/EurMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 51 142.63 mmol/l 0.47 3.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39451 401
SS-Chr YBN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 19 144.74 mmol/l 0.43 1.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39454 401
SS-Chr XBN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 11 144.0 mmol/l 0.62 2.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39457 401
SS/JrHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 143.5 mmol/l 0.58 1.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39460 401
FHH-Chr 11BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 9 142.0 mmol/l 0.73 2.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39461 401
SS/JrHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 2 17.7 g/dl 0.2 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 39473 401
SS-Chr 16BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 18.18 g/dl 0.15 0.38 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 39475 401
Hsd:SD plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 16 23.13 mmol/l 0.81 3.22 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39485 401
Hsd:SD plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 18 22.83 mmol/l 0.78 3.33 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39487 401
LEW/Crl total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 9 5.2 x 1000 cells/ul 0.31 0.93 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39490 401
Crl:CD(SD) total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 9 6.56 x 1000 cells/ul 0.72 2.17 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39491 401
Crl:CD(SD) total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 9 7.54 x 1000 cells/ul 0.49 1.46 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39493 401
LEW/Crl total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 4.89 x 1000 cells/ul 0.4 1.25 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39495 401
F344/DuCrl serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 18 18.67 mg/dl 0.64 2.72 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39514 401
Crl:CD(SD) serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 9 19.44 mg/dl 0.9 2.7 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39515 401
LEW/Crl serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 17.9 mg/dl 0.82 2.6 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39517 401
SS/JrHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 9 0.2 x 1000 cells/ul 0.06 0.18 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39534 401
Hsd:SD plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 18 0.47 mg/dl 0.03 0.11 automated plasma creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39543 401
SS-Chr 20BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 6.51 x 1000 cells/ul 0.81 2.29 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39545 401
SS-Chr 20BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 6.86 x 1000 cells/ul 0.52 1.46 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39548 401
SS-Chr 11BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 15 8.65 x 10E6 cells/ul 0.13 0.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39302 401
SS/JrHsdMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 8.97 x 10E6 cells/ul 0.06 0.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39309 401
SS-Chr 4BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 29 8.66 x 10E6 cells/ul 0.07 0.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39312 401
FHH-Chr 7BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 8.87 x 10E6 cells/ul 0.08 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39314 401
BN/NHsdMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 13 9.54 x 10E6 cells/ul 0.11 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39316 401
SS/JrHsdMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 7 176.43 mg/dl 8.27 21.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39325 401
SS/JrHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 4.49 mmol/l 0.12 0.35 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39332 401
LEW/Crl serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.15 mg/dl 0.12 0.33 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42526 401
SS/JrHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 3 0.52 x 1000 cells/ul 0.14 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 42754 401
FHH-Chr 6BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 96.0 U/l 6.01 19.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42758 401
FHH-Chr 6BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 89.0 U/l 7.1 22.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42759 401
FHH-Chr 2BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 97.0 U/l 2.19 6.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42762 401
FHH-Chr 10BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 103.0 U/l 2.61 7.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42763 401
SHR/NCrl serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 20 126.3 U/l 6.45 28.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42764 401
FHH-Chr 8BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 9 99.56 U/l 6.01 18.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42771 401
SS-Chr 15BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 154.8 U/l 45.95 145.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42773 401
FHH-Chr 18BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 87.8 U/l 3.21 10.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42780 401
SS-Chr 18BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 9 76.22 U/l 5.44 16.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42784 401
SS-Chr 19BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 59.9 U/l 5.88 18.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42792 401
SS-Chr 20BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 26 20.02 pg 0.09 0.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42547 401
SS-Chr 13BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 20.01 pg 0.19 0.65 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42552 401
FHH-Chr YBN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 19.21 pg 0.13 0.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42558 401
FHH-Chr 5BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.6 pg 0.18 0.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42580 401
SS-Chr 10BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 19.53 pg 0.13 0.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42585 401
FHH-Chr 14BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.31 pg 0.12 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42586 401
GH/OmrMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 19.85 pg 0.35 1.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42589 401
FHH-Chr 13BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 19.35 pg 0.07 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42604 401
FHH-Chr 13BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 18.88 pg 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42605 401
SS-Chr YBN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 20 19.51 pg 0.06 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42611 401
SS-Chr XBN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 11 20.81 pg 0.11 0.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42614 401
SS/JrHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 20.02 pg 0.03 0.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42617 401
FHH-Chr 11BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 18.51 pg 0.12 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42618 401
FHH-Chr 11BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 18.76 pg 0.12 0.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42619 401
FHH-Chr 1BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 80.38 U/l 3.22 9.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42796 401
SS-Chr 2BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 15 79.0 U/l 3.91 15.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42797 401
FHH-Chr 5BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 96.5 U/l 6.2 17.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42805 401
FHH-Chr 17BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 6 111.0 U/l 9.75 23.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42816 401
FHH-Chr 19BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 86.5 U/l 3.72 11.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42827 401
SS-Chr 11BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 16 72.75 U/l 4.61 18.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42832 401
SS-Chr 1BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 6 113.5 U/l 15.42 37.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42840 401
FHH-Chr 11BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 82.8 U/l 6.51 20.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42844 401
FHH-Chr 7BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 92.1 U/l 6.7 21.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42847 401
FHH-Chr 17BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 6 110.67 mmol/l 0.49 1.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39163 401
FHH-Chr 19BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 108.8 mmol/l 0.61 1.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39174 401
SS-Chr 4BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 29 107.55 mmol/l 0.4 2.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39188 401
FHH-Chr 9BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 7 109.57 mmol/l 1.17 3.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39193 401
Crl:CD(SD) serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 9 2.1 g/dl 0.09 0.27 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39214 401
FHH-Chr 6BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 9.97 x 10E6 cells/ul 0.13 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39225 401
FHH-Chr 6BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 9 8.91 x 10E6 cells/ul 0.12 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39226 401
FHH-Chr 2BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 9.95 x 10E6 cells/ul 0.15 0.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39229 401
SS-Chr 20BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 26 8.54 x 10E6 cells/ul 0.12 0.59 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39239 401
FHH-Chr 20BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 8.59 x 10E6 cells/ul 0.08 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39246 401
FHH-Chr YBN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 9.53 x 10E6 cells/ul 0.11 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39250 401
FHH-Chr 5BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 8.83 x 10E6 cells/ul 0.19 0.55 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39272 401
SS-Chr 14BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 20 8.85 x 10E6 cells/ul 0.13 0.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39273 401
SS-Chr 6BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 7 9.72 x 10E6 cells/ul 0.14 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39275 401
FHH-Chr 16BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 9 8.72 x 10E6 cells/ul 0.1 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39280 401
FHH-Chr 19BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 9.48 x 10E6 cells/ul 0.12 0.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39290 401
FHH-Chr 13BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 8.21 x 10E6 cells/ul 0.08 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39296 401
FHH-Chr 6BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 142.2 mmol/l 0.44 1.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39377 401
SS-Chr 19BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 142.6 mmol/l 0.67 2.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39410 401
SS-Chr 2BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 146.0 mmol/l 0.45 1.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39411 401
SS-Chr 6BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 145.88 mmol/l 0.69 1.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39426 401
FHH-Chr 8BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 0.85 x 1000 cells/ul 0.11 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43229 401
FHH-Chr 18BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 1.05 x 1000 cells/ul 0.08 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43232 401
SS-Chr 18BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.5 x 1000 cells/ul 0.07 0.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43241 401
SS-Chr 19BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.4 x 1000 cells/ul 0.05 0.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43246 401
FHH-Chr 5BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.6 x 1000 cells/ul 0.04 0.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43254 401
SS-Chr 6BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.48 x 1000 cells/ul 0.07 0.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43257 401
SS-Chr 14BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 20 0.76 x 1000 cells/ul 0.09 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43260 401
FHH-Chr 14BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 1.11 x 1000 cells/ul 0.15 0.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43265 401
SS-Chr 17BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 0.84 x 1000 cells/ul 0.16 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43266 401
SS-Chr 17BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.57 x 1000 cells/ul 0.1 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43271 401
SS-Chr 16BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 13 0.67 x 1000 cells/ul 0.1 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43282 401
LEW/Crl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 120.58 % 5.1 21.66 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54520 381
F344/DuCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 124.73 % 4.78 19.12 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54527 381
LE/BluGill percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 143.83 % 4.59 16.54 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54529 381
SS/JrHsdMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 32.03 g/dl 0.07 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39849 401
FHH-Chr 11BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 31.78 g/dl 0.23 0.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39850 401
SHR/NCrl mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 18 32.17 g/dl 0.12 0.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39771 401
SS-Chr 5BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 31.76 g/dl 0.09 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39775 401
SS-Chr 15BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 31.93 g/dl 0.12 0.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39780 401
FHH-Chr 20BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 29.73 g/dl 2.34 7.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39783 401
SS-Chr 20BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 33 32.24 g/dl 0.08 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39788 401
SS-Chr 18BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 32.08 g/dl 0.08 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39794 401
FHH-Chr 15BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 32.11 g/dl 0.18 0.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39805 401
FHH-Chr 5BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 31.35 g/dl 0.32 0.92 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39812 401
SS-Chr 6BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 32.34 g/dl 0.28 0.74 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39815 401
FHH-Chr 17BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 6 31.95 g/dl 0.12 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39823 401
FHH-Chr 17BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 32.03 g/dl 0.16 0.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39825 401
FHH-Chr 19BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 32.09 g/dl 0.13 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39830 401
FHH-Chr 19BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 31.99 g/dl 0.08 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39834 401
FHH-Chr 13BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 32.0 g/dl 0.11 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39836 401
FHH-Chr 13BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 32.1 g/dl 0.11 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39837 401
FHH/EurMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 49 31.91 g/dl 0.07 0.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39840 401
FHH-Chr 3BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 32.58 g/dl 0.39 1.11 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39841 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.05 x 1000 cells/ul 0.03 0.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39698 401
SS-Chr 9BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 17 0.71 x 1000 cells/ul 0.07 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39708 401
SS-Chr 10BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.06 x 1000 cells/ul 0.04 0.11 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39714 401
FHH-Chr 16BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 9 0.1 x 1000 cells/ul 0.03 0.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39717 401
SS-Chr 17BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.29 x 1000 cells/ul 0.04 0.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39721 401
SS-Chr 7BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 12 0.24 x 1000 cells/ul 0.04 0.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39724 401
SS-Chr 3BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 7 0.32 x 1000 cells/ul 0.04 0.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39730 401
SS-Chr 3BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 7 0.2 x 1000 cells/ul 0.05 0.14 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39735 401
SS-Chr YBN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 20 0.42 x 1000 cells/ul 0.06 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39740 401
SS/JrHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 90 0.4 x 1000 cells/ul 0.03 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39741 401
SS-Chr XBN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 11 0.32 x 1000 cells/ul 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39743 401
SS-Chr 1BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 6 0.24 x 1000 cells/ul 0.08 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39744 401
FHH-Chr 11BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.25 x 1000 cells/ul 0.04 0.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39748 401
BN/NHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 15 0.18 x 1000 cells/ul 0.05 0.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39752 401
FHH-Chr 12BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 32.12 g/dl 0.1 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39762 401
SS-Chr 16BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 6 111.8 % 3.6 8.82 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 54302 381
FHH-Chr 6BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 129.51 % 7.22 19.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54313 381
FHH-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 114.12 % 3.95 13.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54315 381
GH/OmrMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 128.1 % 3.52 9.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54318 381
FHH-Chr XBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 137.97 % 9.75 30.85 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54320 381
FHH-Chr 10BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 137.92 % 8.55 27.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54324 381
FHH-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 122.0 % 6.72 19.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54335 381
FHH-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 117.53 % 8.71 28.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54339 381
SS-Chr 13BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 130.79 % 9.3 27.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54341 381
FHH-Chr 1BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 18 124.99 % 5.18 21.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54344 381
FHH-Chr 4BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 137.96 % 16.08 55.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54347 381
SS-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 125.74 % 10.19 33.81 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54349 381
SS-Chr 9BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 106.87 % 4.2 13.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54361 381
SS-Chr 6BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 134.35 % 7.32 26.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54365 381
FHH-Chr 17BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 122.68 % 7.55 22.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54374 381
SS-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 124.51 % 10.02 33.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54387 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.65 x 1000 cells/ul 0.09 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43214 401
FHH-Chr 12BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 11 0.28 mg/dl 0.01 0.04 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39567 401
FHH-Chr XBN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 7 0.29 mg/dl 0.01 0.04 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39576 401
SS-Chr 20BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 34 0.29 mg/dl 0.01 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39587 401
SS-Chr 14BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 17 0.29 mg/dl 0.02 0.1 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39608 401
SS-Chr 6BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.26 mg/dl 0.05 0.13 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39614 401
FHH-Chr 16BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 9 0.26 mg/dl 0.03 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39619 401
SS-Chr 16BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 16 0.34 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39631 401
SS-Chr 16BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 14 0.31 mg/dl 0.04 0.15 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39634 401
SS-Chr 11BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 16 0.37 mg/dl 0.03 0.12 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39638 401
SS-Chr YBN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 20 0.34 mg/dl 0.02 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39642 401
SS-Chr 4BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 29 0.33 mg/dl 0.01 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39647 401
SS/JrHsdMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.33 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39648 401
FHH-Chr 9BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 7 0.3 mg/dl 0.03 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39652 401
FHH-Chr 7BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.32 mg/dl 0.02 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39658 401
FHH-Chr 10BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.35 x 1000 cells/ul 0.11 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39673 401
FHH-Chr XBN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 7 0.32 x 1000 cells/ul 0.06 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39674 401
FHH-Chr 20BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.38 x 1000 cells/ul 0.06 0.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39680 401
FHH-Chr YBN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 9 0.17 x 1000 cells/ul 0.03 0.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39687 401
SS-Chr 20BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.62 x 1000 cells/ul 0.08 0.23 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43405 401
Hsd:SD blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 15 1.0 x 1000 cells/ul 0.13 0.49 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43407 401
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 0.81 mg/kg 0.17 0.48 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58880 526
FHH-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 11 1.93 mg/kg 0.35 1.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58891 526
SS-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 11 1.64 mg/kg 0.21 0.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58918 526
FHH-Chr 4BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 6 3.05 mg/kg 1.07 2.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58922 526
FHH-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 4.44 mg/kg 1.7 4.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58937 526
SS-Chr 6BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 1.19 mg/kg 0.19 0.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58939 526
FHH-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.39 mg/kg 0.45 1.28 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58949 526
SS-Chr 16BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 112.0 % 10.96 29.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54545 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 111.2 % 8.37 25.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54554 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 136.61 % 5.97 18.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54556 381
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 152.66 % 6.76 20.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54559 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 14 142.66 % 7.0 26.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54561 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 137.64 % 5.85 15.47 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53533 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 121.93 % 4.97 19.27 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53536 381
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 131.46 % 5.91 22.91 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53542 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 106.61 % 3.55 11.23 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53553 381
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 113.26 % 5.31 20.56 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53569 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 111.38 % 4.21 14.59 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53578 381
LEW/Crl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 20 133.32 % 6.46 28.89 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53597 381
WKY/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 20 125.73 % 4.17 18.66 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53599 381
F344/DuCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 137.28 % 11.6 46.41 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53603 381
LE/BluGill percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 157.01 % 9.22 33.24 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53605 381
LE/BluGill percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 105.09 % 7.82 24.74 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53611 381
Crl:CD(SD) percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 101.9 % 3.47 12.51 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53613 381
F344/DuCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 109.0 % 3.3 13.19 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53614 381
LE/BluGill percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 105.41 % 2.71 9.78 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53616 381
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 121.6 % 5.64 16.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53727 381
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 146.77 % 6.75 28.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53739 381
FHH/EurMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 7 0.4 mg/dl 0.02 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Dyets 40381 401
SS-Chr 4BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 20 1.95 mg/kg 0.24 1.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58977 526
SS-Chr YBN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 20 1.0 x 1000 cells/ul 0.09 0.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43290 401
SS-Chr 1BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 6 0.49 x 1000 cells/ul 0.07 0.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43294 401
SS-Chr 4BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 29 0.6 x 1000 cells/ul 0.03 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43299 401
FHH-Chr 7BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 0.91 x 1000 cells/ul 0.13 0.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43306 401
SS-Chr 20BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 22.05 ml/min/kg 2.92 7.16 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59025 526
SS/JrHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.17 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Dyets 59031 526
SS-Chr 16BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.13 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Dyets 59033 526
FHH/EurMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 5 0.23 mmHg x min x kg x ml-1 0.02 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Dyets 59035 526
FHH-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 12 157.8 g 3.4 11.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59047 526
SS-Chr 5BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 218.1 g 7.1 22.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59060 526
FHH-Chr XBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 107.2 g 7.4 23.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59062 526
SS-Chr 15BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 231.8 g 5.3 16.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59065 526
FHH-Chr 20BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 162.0 g 3.9 12.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59071 526
SS-Chr 18BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 22 241.7 g 8.0 37.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59076 526
SS-Chr 18BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 29 174.0 g 2.5 13.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59079 526
SS-Chr 17BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 208.9 g 8.4 26.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59104 526
SS-Chr 16BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 14 265.4 g 7.8 29.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59120 526
FHH-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 138.3 g 8.8 27.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59126 526
SS-Chr 4BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 19 173.4 g 2.3 9.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59137 526
FHH-Chr 7BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 176.2 g 2.9 9.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59139 526
Hsd:SD serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 16 4.05 g/dl 0.06 0.24 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42963 401
FHH-Chr 6BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 46.1 U/l 2.36 7.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40703 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 38.7 U/l 2.52 7.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40704 401
FHH-Chr 2BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 46.63 U/l 1.38 3.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40706 401
SHR/NCrl serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 16 69.13 U/l 3.45 13.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40711 401
SS-Chr 5BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 7 61.43 U/l 4.58 12.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40712 401
FHH-Chr 20BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 55.1 U/l 2.98 9.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40720 401
SS-Chr 18BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 9 35.44 U/l 3.92 11.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40731 401
FHH-Chr 15BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 78.5 U/l 5.8 16.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40742 401
SS-Chr 6BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 9 52.33 U/l 1.98 5.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40747 401
FHH-Chr 5BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 75.0 U/l 4.1 11.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40749 401
SS-Chr 6BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 59.75 U/l 7.49 21.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40752 401
FHH-Chr 17BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 6 66.67 U/l 7.21 17.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40760 401
SS-Chr 17BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 38.5 U/l 1.49 4.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40761 401
FHH-Chr 13BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 63.8 U/l 3.52 11.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40774 401
FHH/EurMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 50 61.3 U/l 3.07 21.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40777 401
FHH-Chr 3BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 61.38 U/l 7.26 20.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40778 401
SS/JrHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 94 52.34 U/l 1.5 14.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40781 401
SS-Chr 1BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 6 65.33 U/l 1.58 3.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40782 401
SS-Chr XBN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 11 49.73 U/l 2.17 7.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40783 401
SS/JrHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 49.4 U/l 2.5 7.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40786 401
LE/BluGill plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 9 0.28 mg/dl 0.01 0.04 automated plasma creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40802 401
LEW/Crl plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.27 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40803 401
SS-Chr 17BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.64 g/dl 0.04 0.12 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40597 401
SS-Chr 7BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 12 2.14 g/dl 0.05 0.16 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40600 401
FHH/EurMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 18 1.76 g/dl 0.04 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40602 401
SS-Chr 3BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 6 1.5 g/dl 0.04 0.09 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40611 401
SS-Chr 11BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 17 1.93 g/dl 0.11 0.44 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40612 401
SS-Chr YBN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 20 2.63 g/dl 0.03 0.12 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40616 401
SS-Chr 4BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 29 2.12 g/dl 0.07 0.39 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40621 401
FHH-Chr 11BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.14 g/dl 0.04 0.12 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40624 401
SS-Chr XBN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.93 g/dl 0.03 0.11 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40630 401
SS/JrHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 9 104.78 mmol/l 0.76 2.28 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40656 401
SS-Chr YBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 20 61.58 % 0.71 3.18 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59323 526
SS-Chr 1BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 11 56.12 % 0.91 3.02 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59325 526
FHH-Chr 11BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 9 55.89 % 1.6 4.81 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59330 526
SS-Chr 4BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 18 53.26 % 0.74 3.13 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59332 526
FHH-Chr 7BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 52.25 % 0.56 1.78 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59334 526
BN/NHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 20 55.49 % 0.42 1.89 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59335 526
Hsd:SD serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 2 82.5 mg/dl 2.5 3.54 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37529 401
SS/JrHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 9 0.34 mg/dl 0.05 0.15 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37531 401
Hsd:SD serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 18 0.25 mg/dl 0.01 0.06 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37534 401
LEW/Crl serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.26 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37542 401
Hsd:SD serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 3 166.67 U/l 22.42 38.84 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37570 401
SS/JrHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 9 9.58 mg/dl 0.28 0.83 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37572 401
Crl:CD(SD) blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 9 0.03 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40503 401
SS-Chr 16BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 33.03 g/dl 0.34 0.89 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40532 401
SS-Chr 15BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.73 g/dl 0.08 0.21 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40554 401
FHH-Chr 18BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.46 g/dl 0.05 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40558 401
FHH-Chr 18BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.25 g/dl 0.05 0.14 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40560 401
SS-Chr 13BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 11 2.85 g/dl 0.05 0.15 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40562 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 9 2.17 g/dl 0.06 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40569 401
SS-Chr 2BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 2.28 g/dl 0.16 0.51 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40573 401
SS-Chr 2BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 15 2.75 g/dl 0.14 0.53 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40577 401
FHH-Chr 14BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.71 g/dl 0.05 0.16 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40581 401
SS-Chr 6BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 9 2.2 g/dl 0.04 0.11 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40583 401
SS-Chr 9BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 17 2.29 g/dl 0.06 0.23 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40584 401
SS-Chr 14BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 20 2.21 g/dl 0.08 0.34 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40586 401
GH/OmrMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 16 2.18 g/dl 0.11 0.45 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40594 401
SS-Chr 5BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 7 55.91 % 0.38 0.99 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59255 526
FHH-Chr XBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 7 51.94 % 0.78 2.08 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59257 526
SS-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 9 56.21 % 0.67 2.0 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59274 526
SS-Chr 17BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 51.73 % 1.03 2.91 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59299 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 14 9.13 mg/dl 0.18 0.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37580 401
FHH-Chr 6BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 10.2 mg/dl 0.25 0.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37583 401
SHR/NCrl serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 17 7.25 mg/dl 0.28 1.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37591 401
FHH-Chr XBN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 7 10.0 mg/dl 0.88 2.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37594 401
FHH-Chr 20BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 8.55 mg/dl 0.15 0.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37600 401
FHH-Chr 18BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 8.04 mg/dl 0.22 0.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37602 401
SS-Chr 18BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 9.4 mg/dl 0.29 0.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37608 401
SS-Chr 19BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 11.01 mg/dl 0.31 0.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37614 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 11 8.5 mg/dl 0.14 0.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37618 401
FHH-Chr 5BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 9.93 mg/dl 0.37 1.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37624 401
SS-Chr 6BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 9 8.64 mg/dl 0.4 1.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37627 401
FHH-Chr 5BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 9.36 mg/dl 0.4 1.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37629 401
SS-Chr 9BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 18 8.53 mg/dl 0.24 1.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37631 401
SS-Chr 6BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 8.81 mg/dl 0.36 1.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37632 401
FHH-Chr 15BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 11.04 mg/dl 0.51 1.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37633 401
SS-Chr 17BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 9.94 mg/dl 0.22 0.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37636 401
FHH-Chr 17BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 6 8.87 mg/dl 0.19 0.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37640 401
FHH-Chr 3BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 10.07 mg/dl 0.45 1.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37648 401
SS-Chr 16BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 16 7.67 mg/dl 0.1 0.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37649 401
FHH-Chr 13BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 8.13 mg/dl 0.35 1.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37653 401
SS-Chr 3BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 6 11.27 mg/dl 0.7 1.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37655 401
SS-Chr 4BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 29 8.63 mg/dl 0.14 0.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37665 401
FHH-Chr 11BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 11.74 mg/dl 1.05 3.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37668 401
BN/NHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 17 7.92 mg/dl 0.2 0.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37673 401
FHH-Chr 7BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 9.56 mg/dl 0.29 0.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37676 401
FHH-Chr 5BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 5.04 x 1000 cells/ul 0.22 0.63 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40956 401
GH/OmrMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 12 3.64 x 1000 cells/ul 0.45 1.55 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40970 401
SS-Chr 17BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 5.54 x 1000 cells/ul 0.72 2.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40973 401
FHH/EurMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 16 3.71 x 1000 cells/ul 0.51 2.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40978 401
FHH-Chr 19BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 6.28 x 1000 cells/ul 0.48 1.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40983 401
SS-Chr 4BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 27 7.64 x 1000 cells/ul 0.2 1.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40997 401
FHH-Chr 11BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 9 5.57 x 1000 cells/ul 0.56 1.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40999 401
FHH-Chr 11BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 5.1 x 1000 cells/ul 0.71 2.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41000 401
FHH-Chr 7BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 6.51 x 1000 cells/ul 0.34 1.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41008 401
FHH-Chr 2BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 27.88 mg/dl 1.33 3.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40820 401
FHH-Chr 8BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 21.0 mg/dl 1.47 4.64 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40833 401
FHH-Chr 20BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 18.9 mg/dl 0.59 1.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40837 401
SS-Chr 13BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 11 18.73 mg/dl 0.9 2.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40840 401
SS-Chr 18BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 16.6 mg/dl 1.06 3.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40842 401
FHH-Chr 4BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 26.38 mg/dl 1.98 5.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40844 401
SS-Chr 12BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 24.75 mg/dl 2.09 5.92 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40853 401
SS-Chr 6BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 9 22.67 mg/dl 0.47 1.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40861 401
FHH-Chr 5BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 27.88 mg/dl 2.55 7.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40863 401
SS-Chr 14BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 20 22.45 mg/dl 0.88 3.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40864 401
SS-Chr 17BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 27.88 mg/dl 1.19 3.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40870 401
FHH/EurMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 51 24.51 mg/dl 0.7 5.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40891 401
FHH-Chr 3BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 25.13 mg/dl 2.76 7.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40892 401
SS-Chr YBN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 20 22.85 mg/dl 0.67 3.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40894 401
SS-Chr XBN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 11 26.73 mg/dl 1.53 5.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40897 401
SS-Chr 4BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 29 20.79 mg/dl 0.59 3.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40899 401
FHH-Chr 8BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 5.29 x 1000 cells/ul 0.22 0.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40927 401
FHH-Chr 20BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 7.39 x 1000 cells/ul 0.36 1.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40935 401
FHH-Chr 18BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 6.36 x 1000 cells/ul 0.54 1.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40936 401
FHH-Chr 1BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 13 5.14 x 1000 cells/ul 0.51 1.82 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40941 401
SS-Chr 18BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 4.14 x 1000 cells/ul 0.64 1.82 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40943 401
FHH-Chr 15BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 13 1.8 g/kg 0.04 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59696 526
FHH-Chr 16BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.69 g/kg 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59700 526
SS-Chr 7BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 12 1.34 g/kg 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59702 526
FHH-Chr 17BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.83 g/kg 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59705 526
SS-Chr 16BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 14 1.22 g/kg 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59715 526
SS-Chr 3BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 12 1.45 g/kg 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59718 526
SS/JrHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 116 1.22 g/kg 0.01 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59724 526
SS/JrHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.53 g/kg 0.08 0.25 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59729 526
SS-Chr 4BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 19 1.39 g/kg 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59732 526
SS-Chr XBN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.28 g/kg 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59737 526
SS/JrHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 5 0.81 null 0.09 0.2 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59741 526
SS/JrHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 0.68 null 0.05 0.13 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59745 526
SS/JrHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 6.93 ml/min/kg 1.07 3.03 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 59749 526
SS-Chr 16BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 14.05 ml/min/kg 1.33 3.26 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 59752 526
SS-Chr 16BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 6 9.15 x 10E6 cells/ul 0.12 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 37917 401
FHH-Chr 12BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 0.19 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59538 526
FHH-Chr 12BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 16.41 g/dl 0.18 0.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37953 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 14 16.71 g/dl 0.65 2.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37954 401
FHH-Chr 12BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 17.8 g/dl 0.18 0.58 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37959 401
FHH-Chr 2BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.27 g/dl 0.34 0.98 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37960 401
SS-Chr 15BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 18.06 g/dl 0.17 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37972 401
SS-Chr 13BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 17.91 g/dl 0.28 0.96 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37975 401
FHH-Chr 18BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 16.81 g/dl 0.23 0.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37976 401
FHH-Chr 18BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 15.67 g/dl 0.28 0.89 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37978 401
FHH-Chr 4BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 16.45 g/dl 0.38 1.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37984 401
FHH-Chr 1BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 17.71 g/dl 0.23 0.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37994 401
SS-Chr 14BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 17 17.15 g/dl 0.24 0.99 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38000 401
SS-Chr 7BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 19.44 g/dl 0.35 1.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38013 401
FHH-Chr 17BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 6 17.35 g/dl 0.15 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38014 401
FHH-Chr 16BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 17.96 g/dl 0.21 0.63 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38019 401
SS/JrHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 90 18.63 g/dl 0.1 0.99 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38035 401
SS-Chr 1BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 6 18.07 g/dl 0.22 0.53 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38036 401
FHH-Chr 9BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 15.82 g/dl 1.2 2.95 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38044 401
BN/NHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 17.83 g/dl 0.15 0.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38046 401
FHH-Chr 9BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 6 17.23 g/dl 0.53 1.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38049 401
SS/JrHsdMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.04 x 1000 cells/ul 0.02 0.05 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37808 401
Crl:CD(SD) serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 9 15.89 mmol/l 0.77 2.32 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41125 401
LE/BluGill serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 9 14.56 mmol/l 0.71 2.13 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41126 401
Crl:CD(SD) serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 9 3.78 g/dl 0.05 0.16 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41133 401
Crl:CD(SD) serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 9 4.49 g/dl 0.1 0.29 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41135 401
LEW/Crl serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.56 g/dl 0.06 0.19 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41137 401
FHH/EurMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 7 2.34 x 1000 cells/ul 0.3 0.8 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41142 401
SS-Chr 16BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 6 7.05 x 1000 cells/ul 0.32 0.79 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41143 401
SS/JrHsdMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 3 3.56 x 1000 cells/ul 0.9 1.57 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41146 401
FHH/EurMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 7 58.43 U/l 8.37 22.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 41155 401
SS-Chr 16BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 7 71.71 U/l 23.03 60.92 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 41157 401
FHH-Chr 12BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 11 5.26 mmol/l 0.16 0.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38057 401
FHH-Chr 2BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 5.1 mmol/l 0.17 0.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38058 401
SHR/NCrl serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 19 4.99 mmol/l 0.12 0.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38060 401
SHR/NCrl serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 16 4.69 mmol/l 0.14 0.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38063 401
SS-Chr 19BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 4.83 mmol/l 0.12 0.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38086 401
SS-Chr 12BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.55 mmol/l 0.2 0.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38091 401
FHH-Chr 5BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.24 mmol/l 0.28 0.8 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38096 401
FHH-Chr 5BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 4.46 mmol/l 0.15 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38101 401
SS-Chr 7BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 9 5.28 mmol/l 0.11 0.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38111 401
SS-Chr 19BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.16 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59567 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.17 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59571 526
SS-Chr 6BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.19 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59585 526
FHH-Chr 14BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.14 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59588 526
SS-Chr 7BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 0.13 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59597 526
FHH-Chr 13BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.15 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59607 526
SS-Chr XBN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 14 0.14 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59616 526
SS-Chr 4BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 22 0.14 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59618 526
SS-Chr XBN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.14 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59627 526
FHH-Chr 2BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.87 g/kg 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59644 526
SHR/NCrl lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 24 1.44 g/kg 0.05 0.23 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59654 526
SS-Chr 15BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.31 g/kg 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59660 526
SS-Chr 13BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 11 1.13 g/kg 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59669 526
SS-Chr 18BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 22 1.27 g/kg 0.03 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59671 526
FHH-Chr 4BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.74 g/kg 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59675 526
SS-Chr 19BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.24 g/kg 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59677 526
SS-Chr 19BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.46 g/kg 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59679 526
SS-Chr 2BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.46 g/kg 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59680 526
SS-Chr 2BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 16 1.18 g/kg 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59684 526
FHH-Chr 14BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 9 1.81 g/kg 0.09 0.27 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59688 526
SS-Chr 16BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 7 31.43 mg/dl 1.84 4.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 41383 401
SS/JrHsdMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 2 8.15 x 1000 cells/ul 0.25 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41482 401
FHH-Chr 2BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 5.96 x 1000 cells/ul 1.19 3.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41490 401
SS-Chr 5BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 7 6.16 x 1000 cells/ul 0.44 1.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41501 401
FHH-Chr XBN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 7 6.68 x 1000 cells/ul 0.78 2.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41503 401
SS-Chr 15BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 6.01 x 1000 cells/ul 0.34 1.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41506 401
FHH-Chr 8BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 4.91 x 1000 cells/ul 0.26 0.84 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41508 401
SS-Chr 2BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 4.26 x 1000 cells/ul 0.19 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41526 401
FHH-Chr 14BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 4.57 x 1000 cells/ul 0.44 1.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41534 401
FHH-Chr 14BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 4.72 x 1000 cells/ul 0.41 1.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41544 401
GH/OmrMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 12 2.76 x 1000 cells/ul 0.38 1.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41547 401
SS-Chr 17BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 4.68 x 1000 cells/ul 0.64 1.82 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41550 401
GH/OmrMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 16 3.77 x 1000 cells/ul 0.48 1.9 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41552 401
SS-Chr 7BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 12 5.49 x 1000 cells/ul 0.34 1.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41553 401
FHH/EurMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 49 4.14 x 1000 cells/ul 0.26 1.8 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41566 401
FHH-Chr 3BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 4.86 x 1000 cells/ul 0.49 1.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41567 401
SS-Chr YBN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 20 5.77 x 1000 cells/ul 0.33 1.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41569 401
SS-Chr 1BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 6 5.73 x 1000 cells/ul 0.49 1.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41571 401
FHH-Chr 9BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 5 4.17 x 1000 cells/ul 0.52 1.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41579 401
FHH-Chr 7BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 4.92 x 1000 cells/ul 0.27 0.86 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41580 401
Crl:CD(SD) serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 9 48.78 U/l 4.25 12.74 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41602 401
F344/DuCrl serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 17 64.59 U/l 5.1 21.03 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41606 401
FHH-Chr 17BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 6 4.5 mmol/l 0.36 0.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38114 401
SS-Chr 3BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 5.47 mmol/l 0.24 0.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38122 401
FHH/EurMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 43 5.28 mmol/l 0.1 0.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38129 401
SS-Chr 1BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 6 6.9 mmol/l 0.53 1.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38134 401
SS-Chr XBN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 11 4.91 mmol/l 0.17 0.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38135 401
BN/NHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 16 4.95 mmol/l 0.18 0.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38144 401
Crl:CD(SD) red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 8.86 x 10E6 cells/ul 0.08 0.24 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38151 401
Crl:CD(SD) serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 9 106.33 mmol/l 0.47 1.41 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38182 401
Crl:CD(SD) serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 9 105.56 mmol/l 0.71 2.13 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38184 401
LE/BluGill serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 9 107.33 mmol/l 0.47 1.41 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38185 401
WKY/NCrl serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 9 104.33 mmol/l 0.6 1.8 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38187 401
SS-Chr 20BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 8.81 x 10E6 cells/ul 0.16 0.45 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38193 401
SS/JrHsdMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 8.89 x 10E6 cells/ul 0.1 0.33 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38195 401
SS-Chr 16BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 7 0.14 x 1000 cells/ul 0.05 0.14 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38199 401
LEW/Crl serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 9 138.78 mmol/l 1.43 4.29 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38237 401
F344/DuCrl serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 18 145.0 mmol/l 0.8 3.4 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38239 401
F344/DuCrl serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 16 143.81 mmol/l 0.61 2.43 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38244 401
FHH-Chr 3BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 19.88 mmol/l 2.38 6.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38325 401
SS-Chr 11BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 15 21.93 mmol/l 1.06 4.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38326 401
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 2 53.65 % 2.05 2.9 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38354 401
LEW/Crl blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 20.6 g/dl 0.47 1.41 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38405 401
SS/JrHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 7 105.14 mmol/l 0.63 1.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 38414 401
FHH-Chr 8BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.04 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41648 401
SS-Chr 15BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41650 401
FHH-Chr 8BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.03 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41652 401
SS-Chr 19BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41669 401
SS-Chr 16BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 15 0.03 x 1000 cells/ul 0.01 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41702 401
FHH-Chr 19BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41704 401
SS-Chr 16BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 13 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41705 401
FHH-Chr 13BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.04 x 1000 cells/ul 0.02 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41707 401
BN/NHsdMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 13 0.18 x 1000 cells/ul 0.05 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41726 401
Hsd:SD total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 5 2.4 x 1000 cells/ul 0.54 1.21 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41732 401
FHH-Chr 6BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 17.2 mmol/l 0.59 1.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38250 401
SHR/NCrl plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 17 22.88 mmol/l 1.17 4.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38258 401
FHH-Chr 8BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 17.9 mmol/l 0.5 1.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38262 401
SS-Chr 13BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 11 27.73 mmol/l 1.87 6.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38273 401
SS-Chr 19BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 17.8 mmol/l 0.66 2.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38283 401
SS-Chr 2BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 13 31.38 mmol/l 1.51 5.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38288 401
FHH-Chr 5BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 17.63 mmol/l 0.5 1.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38291 401
SS-Chr 17BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 22.13 mmol/l 1.22 3.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38303 401
SS-Chr 7BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 11 18.36 mmol/l 1.39 4.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38306 401
FHH-Chr 17BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 6 16.83 mmol/l 1.51 3.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38309 401
SS-Chr 4BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 29 0.12 mg/dl 0.01 0.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41943 401
SHR/NCrl heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 1.28 g 0.04 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45399 461
FHH-Chr 1BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 1.0 g 0.05 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45420 461
SS-Chr 18BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 15 0.84 g 0.06 0.24 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45422 461
SS-Chr 12BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.84 g 0.07 0.22 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45426 461
FHH-Chr 19BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 61.23 % 10.31 32.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48583 461
SS/JrHsdMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 78 post-ischemic value/pre-ischemic value x 100% 34.81 % 2.3 20.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48593 461
FHH-Chr 20BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 121.05 mmHg 4.97 14.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48633 461
SS-Chr 20BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 22 127.76 mmHg 3.4 15.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48635 461
FHH-Chr YBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 88.88 mmHg 5.76 19.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48637 461
SS-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 81.94 mmHg 7.92 25.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48645 461
SS-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 159.27 mmHg 6.89 19.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48647 461
SS-Chr 6BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 161.55 mmHg 4.14 12.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48662 461
SS-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 87.22 mmHg 4.06 12.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48679 461
FHH-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 85.95 mmHg 10.2 28.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48687 461
FHH/EurMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 21.53 % 4.31 9.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48710 461
SS-Chr 16BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 101.95 mmHg 5.06 16.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48725 461
Hsd:SD heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 13 15.23 % 2.26 8.15 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48739 461
SS-Chr 6BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 1.17 g 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45438 461
SS-Chr 14BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 20 0.92 g 0.04 0.19 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45441 461
SS-Chr 6BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 1.04 g 0.09 0.29 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45443 461
FHH-Chr 19BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.8 g 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45461 461
SS-Chr 11BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 23 0.86 g 0.03 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45466 461
SS-Chr XBN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 12 0.66 g 0.05 0.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45473 461
SS/JrHsdMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 19 1.05 g 0.05 0.22 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45476 461
BN/NHsdMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 24 0.74 g 0.03 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45482 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 9.75 IU/g 1.75 5.24 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45488 461
FHH-Chr 2BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 7.62 g/kg 0.31 0.97 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45594 461
FHH-Chr YBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 42.62 mmHg 4.48 14.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46430 461
SS-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 59.04 mmHg 4.3 13.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46477 461
SS-Chr 4BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 17 48.64 mmHg 2.87 11.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46487 461
BN/NHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 21 32.91 mmHg 2.72 12.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46495 461
LE/BluGill heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 11 208.44 beats/min 17.39 57.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46505 461
GH/OmrMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 6 271.62 beats/min 13.53 33.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46514 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 317.09 beats/min 22.83 64.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46517 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 63.36 mmHg 7.08 20.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46531 461
FHH-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.39 IU/g 0.08 0.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47511 461
SS-Chr 16BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 36.92 % 7.71 24.37 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47516 461
FHH/EurMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 42.99 % 2.18 5.76 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47517 461
LE/BluGill percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 61.93 % 5.89 14.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47526 461
LEW/Crl percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 20.8 % 4.17 13.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47527 461
FHH/EurMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 5 53.8 mmHg 9.11 20.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47566 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 250.09 beats/min 11.1 41.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47572 461
FHH-Chr 8BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 235.52 beats/min 6.29 18.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47587 461
SS-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 21 251.89 beats/min 7.46 34.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47589 461
FHH-Chr 1BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 278.29 beats/min 12.74 40.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47597 461
SS-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 276.05 beats/min 7.51 23.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47603 461
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 230.53 beats/min 8.76 27.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47609 461
SS-Chr 10BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 258.52 beats/min 6.48 20.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47622 461
SS-Chr 17BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 261.98 beats/min 5.75 18.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47624 461
FHH-Chr 17BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 17 243.5 beats/min 4.85 20.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47628 461
SS-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 22 259.99 beats/min 6.46 30.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47643 461
SS-Chr YBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 28 235.7 beats/min 6.26 33.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47647 461
FHH-Chr 6BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 30.21 % 5.42 15.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48516 461
FHH-Chr 10BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 46.95 % 6.33 17.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48526 461
SS-Chr 15BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 33.23 % 4.75 15.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48530 461
FHH-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 41.06 % 5.71 15.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48537 461
FHH-Chr 1BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 26.78 % 6.6 20.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48542 461
SS-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 42.62 % 6.19 23.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48544 461
SS-Chr 14BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 34.68 % 5.82 18.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48559 461
SS-Chr 6BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 44.02 % 3.2 9.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48560 461
FHH-Chr 5BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 24.3 % 3.38 6.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48562 461
FHH-Chr 10BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41861 401
SHR/NCrl serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 20 0.19 mg/dl 0.02 0.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41862 401
FHH-Chr 8BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.12 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41869 401
SS-Chr 15BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.14 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41872 401
FHH-Chr 8BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41873 401
FHH-Chr YBN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 9 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41881 401
FHH-Chr 1BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 15 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41883 401
SS-Chr 18BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 9 0.27 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41885 401
SS-Chr 12BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41889 401
FHH-Chr 1BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 9 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41894 401
FHH-Chr 13BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41928 401
FHH-Chr 3BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.13 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41932 401
SS-Chr 15BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 133.25 mg/dl 3.53 9.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38533 401
FHH-Chr 20BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 156.8 mg/dl 5.62 17.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38536 401
SS-Chr 13BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 12 155.25 mg/dl 6.01 20.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38537 401
FHH-Chr 20BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 140.4 mg/dl 4.65 14.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38539 401
SS-Chr 18BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 157.4 mg/dl 7.02 22.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38544 401
SS-Chr 18BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 9 163.44 mg/dl 3.99 11.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38547 401
FHH-Chr 1BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 9 129.56 mg/dl 4.75 14.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38556 401
SS-Chr 14BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 19 158.95 mg/dl 6.43 28.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38566 401
SS-Chr 7BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 11 165.64 mg/dl 6.62 21.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38575 401
SS-Chr 3BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 7 138.29 mg/dl 1.87 4.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38586 401
SS-Chr 3BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 6 154.33 mg/dl 18.87 46.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38591 401
FHH/EurMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 48 149.63 mg/dl 2.92 20.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38593 401
FHH-Chr 7BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 179.9 mg/dl 14.57 46.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38607 401
BN/NHsdMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 20 159.35 mg/dl 4.56 20.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38608 401
SS/JrHsdMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 100 10.69 ml/min/kg 0.32 3.16 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57665 526
SS-Chr 4BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 22 15.56 ml/min/kg 0.62 2.89 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57669 526
FHH-Chr 7BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 14.8 ml/min/kg 0.59 1.88 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57680 526
FHH/EurMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 16.98 ml/min/kg 1.54 4.37 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 57712 526
SS-Chr 16BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 20.4 ml/min/kg 1.35 3.31 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 57713 526
FHH/EurMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 5 0.04 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Dyets 57759 526
LEW/Crl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 5.59 mg/kg 1.03 3.1 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57764 526
Crl:CD(SD) dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 4.15 mg/kg 1.12 3.16 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57767 526
Hsd:SD methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 12.87 ml/min/kg 1.13 2.76 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57784 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 12.83 ml/min/kg 0.82 2.46 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57790 526
FHH-Chr 2BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 19.42 ml/min/kg 1.04 3.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57792 526
SS-Chr 20BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 27 26.12 ml/min/kg 1.18 6.12 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57802 526
SS-Chr 15BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 16.83 ml/min/kg 1.55 4.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57803 526
FHH-Chr 18BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 26.85 ml/min/kg 1.84 5.22 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57808 526
SS-Chr 20BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 38 17.62 ml/min/kg 1.0 6.15 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57811 526
SS-Chr 13BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 15.64 ml/min/kg 0.45 1.41 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57812 526
SS-Chr 16BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 7.02 ml/min/kg 0.42 1.47 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57656 526
FHH/EurMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 53 13.26 ml/min/kg 0.46 3.37 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57661 526
FHH-Chr 3BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 13.05 ml/min/kg 1.84 5.19 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57662 526
SS/JrHsdMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 11.39 ml/min/kg 1.28 3.39 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 57567 526
SS-Chr 16BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 9.02 ml/min/kg 1.09 2.67 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 57570 526
FHH-Chr 10BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 15.05 ml/min/kg 1.43 3.78 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57591 526
SS-Chr 5BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 14.63 ml/min/kg 0.62 1.75 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57596 526
FHH-Chr 20BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 17.42 ml/min/kg 0.27 0.85 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57607 526
FHH-Chr 18BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 18.79 ml/min/kg 1.01 3.2 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57608 526
FHH-Chr 1BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 13 15.64 ml/min/kg 1.23 4.43 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57613 526
SS-Chr 19BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 15.09 ml/min/kg 1.46 4.37 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57618 526
SS-Chr 12BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 14.27 ml/min/kg 1.67 5.0 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57623 526
FHH-Chr 15BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 12.21 ml/min/kg 1.1 3.29 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57637 526
SS-Chr 7BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 18.8 ml/min/kg 1.06 3.67 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57648 526
FHH-Chr 16BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 14.39 ml/min/kg 0.62 1.75 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57649 526
FHH-Chr 3BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 14.86 ml/min/kg 0.81 2.43 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57652 526
FHH-Chr 6BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 75.22 % 3.95 12.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48744 461
FHH-Chr 12BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 73.96 % 7.93 26.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48747 461
SS-Chr 20BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 22 post-ischemic value/pre-ischemic value x 100% 63.55 % 6.95 32.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48758 461
SS-Chr 15BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 81.43 % 5.13 13.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48760 461
SS-Chr 13BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 66.77 % 8.5 31.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48768 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 69.94 % 12.15 38.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48780 461
FHH-Chr 1BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 68.29 % 3.41 10.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48782 461
FHH-Chr 5BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 66.93 % 3.42 9.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48786 461
SS-Chr 17BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 91.65 % 4.15 12.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48803 461
FHH/EurMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 84.63 % 2.95 11.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48807 461
FHH-Chr 3BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 90.74 % 5.43 12.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48809 461
FHH-Chr 13BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 80.48 % 4.59 13.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48815 461
Crl:CD(SD) left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 142.0 mmHg 4.41 13.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47668 461
LE/BluGill heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 376.9 beats/min 12.54 37.63 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16131 381
SS-Chr 20BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 27 48.23 ml/min/kg 2.25 11.7 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58001 526
SS-Chr 15BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 61.62 ml/min/kg 5.7 16.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58003 526
FHH-Chr 20BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 58.25 ml/min/kg 2.6 8.23 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58008 526
SS-Chr 20BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 37 37.06 ml/min/kg 2.3 14.0 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58010 526
FHH-Chr 4BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 56.62 ml/min/kg 7.13 20.15 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58017 526
SS-Chr 12BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 68.11 ml/min/kg 5.49 16.48 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58020 526
SS-Chr 2BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 50.41 ml/min/kg 4.22 13.34 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58022 526
SS-Chr 12BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 55.36 ml/min/kg 6.39 19.18 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58024 526
FHH-Chr 15BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 62.65 ml/min/kg 9.87 27.91 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58027 526
FHH-Chr 16BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 57.02 ml/min/kg 1.83 4.84 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58042 526
SS-Chr 7BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 59.53 ml/min/kg 4.24 14.69 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58044 526
FHH-Chr 3BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 49.58 ml/min/kg 4.09 12.27 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58053 526
FHH-Chr 1BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 18 37.47 degrees C 0.16 0.67 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16587 381
FHH-Chr 6BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 36.9 degrees C 0.25 0.84 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16560 381
FHH-Chr 10BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.54 degrees C 0.18 0.56 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16565 381
SS-Chr 20BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 17 37.38 degrees C 0.16 0.65 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16574 381
FHH-Chr 18BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 36.59 degrees C 0.19 0.65 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16582 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.42 degrees C 0.22 0.69 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16591 381
SS-Chr 2BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 37.1 degrees C 0.27 0.93 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16595 381
FHH-Chr 1BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 15 37.46 degrees C 0.09 0.36 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16598 381
FHH-Chr 5BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.7 degrees C 0.11 0.35 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16602 381
SS-Chr 9BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 20 37.19 degrees C 0.12 0.54 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16610 381
FHH-Chr 15BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 37.18 degrees C 0.19 0.58 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16612 381
FHH-Chr 17BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 36.63 degrees C 0.25 0.82 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16619 381
FHH-Chr 3BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.96 degrees C 0.1 0.33 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16627 381
SS-Chr 16BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 14 38.0 degrees C 0.13 0.49 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16628 381
SS-Chr 3BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 37.36 degrees C 0.22 0.75 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16629 381
FHH-Chr 13BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.91 degrees C 0.14 0.43 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16632 381
SS-Chr 11BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.64 degrees C 0.48 1.53 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16635 381
SS-Chr YBN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 19 38.0 degrees C 0.12 0.5 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16639 381
SS/JrHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 76 37.4 degrees C 0.1 0.86 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16640 381
SS-Chr 4BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 15 37.13 degrees C 0.25 0.95 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16648 381
FHH-Chr 9BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.39 degrees C 0.16 0.5 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16649 381
FHH-Chr 7BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.41 degrees C 0.22 0.65 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16655 381
FHH-Chr 3BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 23.19 ml/min/kg 2.37 6.71 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57864 526
SS-Chr 1BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 29.99 ml/min/kg 1.02 3.07 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57870 526
FHH-Chr 12BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 43.78 ml/min/kg 3.48 10.99 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57990 526
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 0.37 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 16325 381
LEW/Crl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 12 26.31 mmHg 0.72 2.48 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16369 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 27.41 mmHg 1.05 2.76 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16450 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 3 28.92 mmHg 1.0 1.73 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16454 381
FHH-Chr 13BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 60.03 ml/min/kg 4.64 14.68 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58058 526
SS-Chr 20BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 13.04 ml/min/kg 1.07 2.83 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58426 526
SS/JrHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 15.86 ml/min/kg 1.29 3.17 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58427 526
Hsd:SD body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 7 323.6 g 4.5 12.0 whole body digital scale 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58434 526
SS/JrHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 11 176.7 g 3.7 12.2 whole body digital scale 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58437 526
FHH-Chr 9BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 0.44 null 0.07 0.18 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58194 526
SS-Chr 16BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 6 54.92 % 0.58 1.42 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Dyets 58200 526
BN/NHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 26 66.45 ml/min/kg 4.43 22.57 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58078 526
FHH-Chr 7BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 43.34 ml/min/kg 2.09 6.59 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58081 526
LEW/Crl fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 8 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58083 526
LE/BluGill fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 14 0.04 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58091 526
FHH-Chr 2BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.48 null 0.04 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58100 526
FHH-Chr 10BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 0.68 null 0.06 0.15 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58106 526
SS-Chr 5BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.53 null 0.04 0.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58108 526
FHH-Chr 8BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.55 null 0.04 0.12 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58114 526
SS-Chr 15BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.39 null 0.04 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58116 526
FHH-Chr 20BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.46 null 0.03 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58122 526
SS-Chr 18BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.32 null 0.02 0.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58127 526
SS-Chr 6BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.53 null 0.14 0.4 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58151 526
SS-Chr 17BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.42 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58155 526
GH/OmrMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.3 null 0.04 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58162 526
SS-Chr 16BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.34 null 0.02 0.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58168 526
SS-Chr 3BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.47 null 0.04 0.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58169 526
FHH-Chr 3BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.54 null 0.05 0.15 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58177 526
SS-Chr 1BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.38 null 0.03 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58181 526
FHH-Chr 9BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.44 null 0.04 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58189 526
SS-Chr 10BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 20.76 ml/min/kg 1.51 4.26 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57829 526
FHH-Chr 14BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 5 28.69 ml/min/kg 2.06 4.61 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57831 526
SS-Chr 17BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 24.85 ml/min/kg 2.33 7.0 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57847 526
FHH-Chr 17BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 27.54 ml/min/kg 1.48 4.67 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57848 526
FHH-Chr 2BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58476 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58479 526
SHR/NCrl fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 19 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58486 526
FHH-Chr 8BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.03 mmHg-1 0.0 0.0 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58490 526
FHH-Chr 8BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58494 526
FHH-Chr 20BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58495 526
FHH-Chr 18BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58497 526
FHH-Chr 1BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58515 526
SS-Chr 6BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58527 526
FHH-Chr 14BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.02 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58530 526
FHH/EurMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 11 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58541 526
FHH-Chr 19BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58542 526
SS-Chr 3BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 14 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58545 526
FHH/EurMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 54 0.04 mmHg-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58552 526
SS-Chr 11BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 17 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58554 526
WKY/NCrl methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.33 null 0.03 0.08 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58579 526
LE/BluGill hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 59.49 % 0.93 2.95 microhematocrit tube assay with visual assessment 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58591 526
SS-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 5 1.06 mg/kg 0.45 1.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58601 526
SS-Chr 17BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 0.89 mg/kg 0.32 0.85 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58948 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 98 1.6 mg/kg 0.11 1.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58973 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.32 mg/kg 0.29 0.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58978 526
FHH-Chr 11BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.52 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58806 526
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 5 57.32 % 0.36 0.81 microhematocrit tube assay with visual assessment 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58817 526
WKY/NCrl methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 12.88 ml/min/kg 1.79 5.37 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58834 526
FHH/EurMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 6 1.32 g/kg 0.07 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 58877 526
SS/JrHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 11 1.19 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 58878 526
SS/JrHsdMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 11 0.34 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 58890 526
FHH-Chr 6BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 6 1.84 mg/kg 0.25 0.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58894 526
SS-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 26 1.08 mg/kg 0.1 0.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58908 526
FHH-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 2.42 mg/kg 0.72 2.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58934 526
Crl:CD(SD) heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.34 null 0.03 0.09 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59968 526
SS/JrHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 9 1.19 g/kg 0.04 0.12 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58702 526
Hsd:SD lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 7 1.03 g/kg 0.02 0.05 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58703 526
Hsd:SD calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.1 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58713 526
FHH-Chr 6BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.42 null 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58721 526
SS-Chr 18BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 22 0.38 null 0.02 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58747 526
GH/OmrMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 35 0.31 null 0.01 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58777 526
FHH/EurMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 20 0.33 null 0.03 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58785 526
SS-Chr 16BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 15 0.31 null 0.02 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58788 526
LE/BluGill methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 13 12.13 ml/min/kg 0.52 1.88 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59865 526
Hsd:SD FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 5 15.62 ml/min/kg 0.67 1.49 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 60092 526
F344/DuCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 18 161.8 g 8.4 35.4 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60099 526
F344/DuCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 17 152.2 g 7.0 28.8 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60104 526
LE/BluGill body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 15 280.7 g 11.0 42.6 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60105 526
LEW/Crl FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 29.13 ml/min/kg 1.62 4.86 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60134 526
Hsd:SD blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 12 7.5 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17455 381
LEW/Crl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 0.29 ml 0.01 0.06 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16033 381
LE/BluGill tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.29 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16037 381
Crl:CD(SD) left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 43.91 mmHg 11.55 32.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45905 461
WKY/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 72.86 mmHg 12.86 40.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45909 461
SS/JrHsdMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 17.76 % 17.76 35.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45924 461
FHH/EurMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 77.49 % 7.64 17.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45925 461
SS-Chr 18BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 73.4 % 11.09 31.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45926 461
LEW/Crl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 61.22 mmHg 3.49 11.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45932 461
LE/BluGill left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 34.52 mmHg 4.32 14.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45937 461
FHH-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 18.72 IU/g 2.37 6.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45958 461
FHH-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 20 29.2 IU/g 1.64 7.34 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45966 461
FHH-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 19.42 IU/g 1.53 4.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45979 461
FHH-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 26.68 IU/g 3.46 9.8 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45981 461
SS-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 24.59 IU/g 4.83 15.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45989 461
SS-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 8.76 IU/g 1.36 3.61 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46010 461
FHH-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 3.16 ml/min/g 0.52 1.55 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44705 461
FHH-Chr 6BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 3.1 ml/min/g 0.27 0.76 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44707 461
SS-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 5.85 ml/min/g 0.63 1.79 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44716 461
FHH-Chr 10BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 5.2 ml/min/g 0.62 1.76 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44717 461
FHH-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 7.21 ml/min/g 0.71 2.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44726 461
SS-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 4.18 ml/min/g 0.39 1.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44743 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 6.52 ml/min/g 0.72 2.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44745 461
SS-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 11 5.59 ml/min/g 0.25 0.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44763 461
SS-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 6.73 ml/min/g 0.32 1.02 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44767 461
SS-Chr XBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 87.06 mmHg 8.31 27.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45808 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 4 175.25 mmHg 11.56 23.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45812 461
FHH/EurMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 7 1.54 g 0.06 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 45831 461
GH/OmrMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 877.97 s 91.2 273.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45841 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 167.6 mmHg 14.06 31.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45868 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 4 303.31 beats/min 13.52 27.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45870 461
WKY/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 65.74 mmHg 10.94 30.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45901 461
FHH-Chr 19BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 12.09 ml/min/g 0.58 1.82 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46705 461
SS-Chr 1BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 10.45 ml/min/g 1.4 3.97 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46720 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 17 10.45 ml/min/g 0.56 2.32 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46724 461
SS-Chr XBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 11 11.57 ml/min/g 0.52 1.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46732 461
SS-Chr 15BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 121.05 mmHg 9.5 28.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45733 461
FHH-Chr 20BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 128.38 mmHg 4.83 15.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45735 461
SS-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 158.91 mmHg 9.27 26.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45756 461
SS-Chr 6BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 156.71 mmHg 6.49 19.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45762 461
FHH-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 131.18 mmHg 6.54 17.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45764 461
SS-Chr 9BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 16 144.31 mmHg 7.35 29.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45766 461
FHH-Chr 15BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 101.56 mmHg 8.69 22.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45768 461
SS-Chr 10BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 127.02 mmHg 8.31 21.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45769 461
FHH-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 77.74 mmHg 12.99 31.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45770 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 122.53 mmHg 4.73 17.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45780 461
SS-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 92.09 mmHg 3.83 11.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45784 461
SS-Chr 16BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 17 109.19 mmHg 4.95 20.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45786 461
FHH-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 10.4 ml/min/g 0.69 1.94 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46645 461
SS-Chr 20BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 23 11.37 ml/min/g 0.7 3.37 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46655 461
FHH-Chr 20BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 11.53 ml/min/g 0.91 2.88 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46659 461
FHH-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 14.1 ml/min/g 0.81 2.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46661 461
FHH-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 13.17 ml/min/g 0.66 1.98 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46663 461
FHH-Chr 1BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 14.88 ml/min/g 1.14 3.59 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46668 461
FHH-Chr 14BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 4 17.65 ml/min/g 3.77 7.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46684 461
FHH-Chr 15BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 9.99 ml/min/g 0.44 1.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46692 461
GH/OmrMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 11.53 ml/min/g 1.28 3.4 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46697 461
SS-Chr 9BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 5.34 g/kg 0.14 0.43 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45599 461
SS-Chr 7BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 11 5.48 g/kg 0.13 0.44 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45614 461
FHH-Chr 19BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 7.2 g/kg 0.31 0.99 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45629 461
SS-Chr 16BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 22 6.02 g/kg 0.38 1.78 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45631 461
FHH-Chr 13BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 7.19 g/kg 0.27 0.8 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45638 461
SS-Chr 20BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 15 5.99 g/kg 0.29 1.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45646 461
SS-Chr 18BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 15 6.56 g/kg 0.4 1.55 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45660 461
SS-Chr 12BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 5.42 g/kg 0.24 0.75 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45669 461
FHH-Chr 7BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 6.76 g/kg 0.23 0.72 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45673 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 33 9.64 IU/g 0.9 5.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45696 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 35.35 mmHg 4.97 13.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46148 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 41.68 % 4.12 15.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47063 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 48.49 % 4.72 17.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47067 461
FHH-Chr XBN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 42.76 % 2.99 7.91 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47073 461
SS-Chr 20BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 23 post-ischemic value/pre-ischemic value x 100% 42.33 % 5.42 25.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47079 461
SS-Chr 20BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 25 post-ischemic value/pre-ischemic value x 100% 39.15 % 3.37 16.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47088 461
FHH-Chr 1BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 47.68 % 2.98 9.41 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47092 461
SS-Chr 12BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 45.22 % 3.81 12.06 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47098 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 58.34 mmHg 6.63 22.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46403 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 56.52 mmHg 3.21 11.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46407 461
SS-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 18 45.68 mmHg 3.88 16.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46424 461
SS-Chr 16BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 19 5.76 mmHg 0.21 0.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47254 461
SS-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 6.31 mmHg 0.25 0.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47257 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 47 5.45 mmHg 0.12 0.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47259 461
SS-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 22 5.52 mmHg 0.16 0.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47261 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 84 5.61 mmHg 0.08 0.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47263 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 16 5.59 mmHg 0.17 0.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47268 461
FHH-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.58 mmHg 0.23 0.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47269 461
FHH-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 5.36 mmHg 0.15 0.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47270 461
SS-Chr 4BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 16 5.31 mmHg 0.2 0.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47271 461
FHH-Chr 9BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 5.49 mmHg 0.19 0.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47272 461
FHH-Chr 10BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 85.5 % 9.75 19.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48288 461
F344/DuCrl heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.65 g 0.03 0.1 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45038 461
GH/OmrMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 57.56 mmHg 6.5 19.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45061 461
Hsd:SD heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 11 1.3 g 0.1 0.34 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45063 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 184.12 beats/min 23.58 52.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45078 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 5 225.17 beats/min 14.97 33.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45080 461
SS-Chr 16BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 12 5.38 ml/min/g 0.36 1.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45095 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 4 40.49 IU/g 5.92 11.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46011 461
FHH/EurMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 150.73 % 36.24 95.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46036 461
Crl:CD(SD) time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1139.63 s 43.43 137.34 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45103 461
Crl:CD(SD) time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1139.17 s 46.23 146.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45105 461
WKY/NCrl time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 1179.4 s 75.27 212.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45109 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 5.24 IU/g 1.89 4.22 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45115 461
FHH-Chr 6BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 247.62 beats/min 32.8 103.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45136 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 13 273.2 beats/min 40.93 147.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45138 461
SS-Chr 15BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 220.39 beats/min 8.16 25.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45151 461
SS-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 17 226.19 beats/min 6.24 25.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45155 461
FHH-Chr 20BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 192.48 beats/min 9.16 27.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45157 461
SS-Chr 20BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 22 263.86 beats/min 24.54 115.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45159 461
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 232.16 beats/min 11.92 44.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45165 461
FHH-Chr 1BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 223.08 beats/min 5.09 16.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45174 461
SS-Chr 16BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 11.62 ml/min/g 0.47 1.42 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46288 461
SS-Chr 10BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 59.19 % 3.58 10.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47106 461
SS-Chr 10BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 54.19 % 3.53 9.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47117 461
SS-Chr 7BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 48.31 % 1.42 4.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47122 461
SS-Chr 7BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 62.43 % 4.99 15.78 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47126 461
FHH-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 46.79 % 6.82 15.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47130 461
SS-Chr 16BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 53.58 % 6.45 27.37 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47134 461
FHH-Chr 11BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 29.49 % 1.6 5.06 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47149 461
BN/NHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 21 post-ischemic value/pre-ischemic value x 100% 57.27 % 3.35 15.34 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47155 461
SS-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 56.79 % 10.41 29.44 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47172 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 12 5.81 mmHg 0.1 0.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47187 461
SS-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 16 4.93 mmHg 0.3 1.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47209 461
SS-Chr 6BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 5.72 mmHg 0.18 0.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47230 461
FHH-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 6.09 mmHg 0.24 0.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47232 461
SS-Chr 9BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 17 5.47 mmHg 0.13 0.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47234 461
FHH-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 5.25 mmHg 0.32 0.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47238 461
FHH-Chr 19BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 5.44 mmHg 0.13 0.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47249 461
Crl:CD(SD) percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 63.54 % 2.82 8.92 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47884 461
LE/BluGill left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.85 mmHg 0.22 0.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48012 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 48 4.68 ml/min/g 0.24 1.68 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44780 461
SS-Chr XBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 5.87 ml/min/g 0.59 1.78 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44786 461
BN/NHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 24 10.02 ml/min/g 0.75 3.69 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44795 461
SS-Chr XBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 11 7.34 ml/min/g 0.81 2.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44797 461
Crl:CD(SD) time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 831.13 s 52.0 164.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48120 461
LE/BluGill time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 11 983.73 s 101.76 337.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48124 461
SS-Chr 10BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 274.3 beats/min 50.0 149.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45188 461
FHH-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 19 226.75 beats/min 17.53 76.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45191 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 13 147.76 beats/min 12.14 43.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45199 461
FHH-Chr 19BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 206.6 beats/min 10.31 30.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45204 461
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 201.83 beats/min 12.42 39.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45208 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 43 223.63 beats/min 17.45 114.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45210 461
FHH-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 153.29 beats/min 9.05 27.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45220 461
SS-Chr 4BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 19 240.05 beats/min 18.91 82.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45222 461
FHH-Chr 9BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 180.91 beats/min 8.45 25.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45228 461
SS-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 256.64 beats/min 31.76 89.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45251 461
GH/OmrMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 189.11 beats/min 10.37 31.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45254 461
SS-Chr 5BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 23.28 mmHg 4.42 12.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45268 461
SS-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 68.15 mmHg 11.65 36.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45297 461
FHH-Chr 17BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 17 43.84 mmHg 6.58 27.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45316 461
SS-Chr 16BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 16 27.52 mmHg 4.18 16.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45327 461
FHH-Chr 9BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 48.42 mmHg 8.23 24.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45345 461
BN/NHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 24 71.06 mmHg 3.3 16.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45347 461
FHH-Chr 9BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 26.99 mmHg 7.35 22.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45350 461
SS-Chr 18BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 8 1.32 g 0.03 0.08 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45383 461
SS-Chr 18BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 716.67 s 51.79 146.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45385 461
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 4.25 mmHg 0.25 0.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47377 461
FHH-Chr 6BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 0.27 IU/g 0.03 0.09 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47433 461
SS-Chr 9BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 18 0.39 IU/g 0.03 0.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47436 461
FHH-Chr 10BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.53 IU/g 0.14 0.41 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47454 461
FHH-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 19 0.37 IU/g 0.06 0.26 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47455 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 21 0.23 IU/g 0.02 0.1 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47460 461
SS-Chr 5BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 81.76 % 4.45 10.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48293 461
SS-Chr 15BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 82.86 % 3.78 11.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48298 461
FHH-Chr 4BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 92.03 % 3.09 9.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48313 461
SS-Chr 19BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 80.04 % 3.49 9.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48317 461
SS-Chr 12BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 82.61 % 3.47 9.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48320 461
FHH-Chr 14BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 92.92 % 3.0 7.34 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48336 461
FHH-Chr 16BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 91.97 % 6.05 26.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48338 461
SS-Chr 7BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 121.62 % 23.04 72.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48344 461
SS-Chr 4BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 86.34 % 6.17 26.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48369 461
LEW/Crl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.37 IU/g 0.02 0.08 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48378 461
LEW/Crl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.4 IU/g 0.05 0.16 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48384 461
Crlj:WI heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 6 372.0 beats/min 11.0 26.94 vascular transducer tipped catheter 0.0 0 103035 2784
Crlj:WI heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 384.0 beats/min 17.0 44.98 vascular transducer tipped catheter 0.0 0 103044 2784
GK heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 5 366.0 beats/min 17.0 38.01 vascular transducer tipped catheter 0.0 0 103045 2784
SS/JrHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.5 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20113 381
SS/JrHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 7.49 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20119 381
FHH-Chr 20BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 132.74 % 8.34 23.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53764 381
FHH-Chr 4BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 129.79 % 11.33 40.84 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53772 381
FHH-Chr 1BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 16 119.63 % 8.05 32.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53780 381
FHH-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 99.18 % 5.77 18.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53869 381
FHH-Chr 10BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 118.01 % 7.58 23.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53883 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 118.59 % 6.31 26.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53897 381
SS-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 116.59 % 5.53 19.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53910 381
SS-Chr XBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 99.46 % 5.12 17.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53954 381
FHH-Chr 7BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 122.03 % 6.03 20.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53962 381
FHH-Chr 9BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 103.37 % 6.02 18.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53965 381
FHH-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 96.69 % 7.51 23.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53976 381
WKY/NCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 15 36.81 degrees C 0.19 0.75 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19989 381
WKY/NCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 19.08 % 8.84 27.96 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49036 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 104.4 mmHg 6.24 13.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49157 461
F344/DuCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 129.3 breaths/min 4.39 17.55 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18209 381
FHH-Chr 5BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 165.56 breaths/min 9.78 30.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18301 381
FHH-Chr XBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 39.64 ml/min 2.39 7.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20204 381
FHH-Chr 10BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 23.85 ml/min 1.76 5.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20207 381
FHH-Chr 8BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 32.01 ml/min 2.66 8.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20209 381
SS-Chr 13BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 40.54 ml/min 6.65 21.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20215 381
FHH-Chr 1BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 18 42.73 ml/min 1.9 8.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20223 381
SS-Chr 9BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 45.13 ml/min 3.83 12.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20243 381
FHH-Chr 17BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 31.25 ml/min 2.29 7.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20255 381
WKY/NCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 10 -7.3 mmHg 0.53 1.69 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20987 381
LEW/Crl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 1 118.47 % stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 53748 381
FHH-Chr 10BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 114.84 % 3.98 12.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53751 381
SS-Chr 20BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 17 129.99 % 7.67 31.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53756 381
SS-Chr 10BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 53.09 mmHg 1.4 3.95 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20448 381
SHR/NCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 11 53.93 mmHg 1.69 5.61 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20472 381
FHH-Chr 8BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 51.04 mmHg 1.55 3.8 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20486 381
SS-Chr 16BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 11 885.87 s 47.83 158.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48924 461
GH/OmrMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 1126.31 s 65.26 195.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48929 461
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 74 51.99 ml/min 1.61 13.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20276 381
FHH-Chr 9BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 23.78 ml/min 2.55 8.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20285 381
FHH-Chr 17BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 0.16 degrees C 0.25 0.84 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20356 381
FHH/EurMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 14 -0.61 degrees C 0.22 0.82 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20362 381
FHH-Chr 13BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 0.31 degrees C 0.2 0.66 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20370 381
FHH-Chr 7BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 0.24 degrees C 0.2 0.61 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20392 381
FHH-Chr 11BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.37 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15307 381
SS-Chr 4BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 0.31 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15309 381
FHH-Chr 5BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 98.69 % 6.73 21.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54017 381
SS-Chr 14BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 106.36 % 4.54 15.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54023 381
FHH-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 108.96 % 5.76 18.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54039 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 103.98 breaths/min 4.03 11.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15379 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 8 120.93 mmHg 6.37 18.01 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14410 381
FHH/EurMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 6 126.12 mmHg 5.73 14.04 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14415 381
SS-Chr 1BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.26 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15304 381
SS-Chr 18BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 7 0.47 degrees C 0.21 0.55 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19577 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 16 -6.89 mmHg 0.45 1.81 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19653 381
SS-Chr 18BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.52 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17604 381
SS-Chr 16BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.54 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17610 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 145.7 breaths/min 8.4 26.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17684 381
FHH/EurMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 125.82 mmHg 3.56 10.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14667 381
FHH-Chr 16BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 130.98 mmHg 6.21 18.63 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14329 381
FHH-Chr 19BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 10 130.8 mmHg 5.3 16.74 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14332 381
FHH-Chr 20BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 7.47 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17061 381
FHH-Chr 18BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.47 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17067 381
FHH/EurMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 16 7.5 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17069 381
FHH-Chr 4BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 2 7.47 null 0.05 0.07 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17080 381
F344/DuCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 30.96 ml/min 1.47 6.22 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18970 381
Hsd:SD serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 5 9.06 mg/dl 0.61 1.36 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36295 401
F344/DuCrl serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 17 157.94 mg/dl 5.18 21.34 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36327 401
FHH/EurMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 7 137.71 mmol/l 0.61 1.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36338 401
Crl:CD(SD) hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 56.52 % 0.73 2.19 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36346 401
LEW/Crl mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 19.07 pg 0.11 0.34 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36360 401
FHH-Chr 2BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 360.63 U/l 8.02 22.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36371 401
SS-Chr 5BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 178.5 U/l 6.51 18.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36374 401
SS-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 4 463.94 beats/min 9.59 19.19 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18758 381
FHH/EurMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 4 0.03 null 0.03 0.06 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18785 381
FHH/EurMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 -0.45 degrees C 0.14 0.48 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14131 381
SS-Chr 16BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 6 0.0 degrees C 0.22 0.54 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14134 381
GH/OmrMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 %change=VE during 2-3 min hypoxia/control during standard conditions 152.64 % 6.04 15.98 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14147 381
GH/OmrMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 4 159.77 mmHg 3.14 6.28 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14319 381
SS-Chr 18BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 9 128.67 U/l 10.36 31.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36396 401
SS-Chr 12BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 130.25 U/l 8.18 23.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36404 401
FHH-Chr 15BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 454.5 U/l 16.52 46.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36407 401
FHH-Chr 16BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 4 25.19 mmHg 0.9 1.8 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17229 381
FHH-Chr 8BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 6 28.96 mmHg 0.91 2.23 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17240 381
FHH-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 8 31.15 mmHg 1.21 3.43 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17259 381
FHH-Chr 11BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 2 25.25 mmHg 3.6 5.09 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17273 381
SS-Chr 19BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 3 30.12 mmHg 1.72 2.98 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17275 381
FHH-Chr 10BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 5.0 g/dl 0.11 0.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36955 401
SS-Chr 13BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 11 6.8 g/dl 0.07 0.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36974 401
FHH-Chr 15BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 4.69 g/dl 0.12 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37001 401
SS/JrHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 3 19.23 pg 0.15 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 37076 401
SS-Chr 15BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 85.75 mg/dl 3.69 10.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37101 401
FHH-Chr 4BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 7 66.57 mg/dl 3.64 9.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37115 401
SS-Chr 19BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 79.7 mg/dl 2.38 7.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37117 401
SS-Chr 2BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 83.6 mg/dl 3.33 10.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37120 401
FHH-Chr 19BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 74.6 mg/dl 2.45 7.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37150 401
SS-Chr 3BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 7 76.71 mg/dl 3.68 9.74 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37153 401
SS-Chr 4BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 29 79.59 mg/dl 1.04 5.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37172 401
FHH-Chr 9BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 7 73.29 mg/dl 3.14 8.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37178 401
SS-Chr 10BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 125.68 breaths/min 6.53 20.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18306 381
FHH-Chr 16BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 144.86 breaths/min 7.9 29.57 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18309 381
SS-Chr 7BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 133.22 breaths/min 6.39 19.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18311 381
SS-Chr 4BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 105.08 breaths/min 6.69 22.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18337 381
FHH-Chr 13BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 34.52 ml/min 2.7 8.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18723 381
SS-Chr 1BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 54.44 ml/min 3.68 11.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18731 381
FHH-Chr 9BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 25.82 ml/min 1.52 4.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18739 381
SS-Chr 5BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.36 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15231 381
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.46 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13834 381
FHH-Chr 10BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.21 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13916 381
FHH/EurMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 7 9.19 mg/dl 0.12 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37293 401
FHH-Chr 4BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 120.65 breaths/min 10.97 37.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14812 381
SS-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 104.14 breaths/min 6.17 21.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14817 381
SS-Chr 10BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 133.82 breaths/min 6.5 21.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14823 381
FHH-Chr 8BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.33 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13928 381
FHH-Chr 4BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 0.33 ml 0.03 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13939 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 0.39 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13947 381
SS-Chr 16BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 0.41 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13982 381
FHH-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.22 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13988 381
SS-Chr XBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 0.23 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13993 381
LEW/Crl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 0.32 ml 0.01 0.06 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14009 381
SS-Chr 17BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 133.68 % 7.93 25.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13728 381
SS-Chr 16BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 %change=VE during 2-3 min hypoxia/control during standard conditions 145.46 % 7.64 28.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13736 381
FHH/EurMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 49 %change=VE during 2-3 min hypoxia/control during standard conditions 133.12 % 3.59 25.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13744 381
SS-Chr 16BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 5 -49.08 mmHg 2.85 6.38 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18643 381
FHH-Chr 6BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 44.81 ml/min 6.19 16.37 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18651 381
FHH-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 43.49 ml/min 2.84 8.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18654 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 20 66.93 ml/min 4.04 18.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18656 381
FHH-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 31.95 ml/min 2.4 6.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18670 381
SS-Chr 14BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 34.44 ml/min 2.87 9.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18694 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 13 399.04 beats/min 8.58 30.94 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17545 381
FHH-Chr 14BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 149.55 breaths/min 3.37 10.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14836 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 119.11 breaths/min 7.04 24.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14867 381
FHH-Chr YBN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 9 9.39 mg/dl 0.06 0.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36637 401
FHH-Chr 4BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.65 mg/dl 0.13 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36640 401
FHH-Chr 4BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 7 9.37 mg/dl 0.14 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36642 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 11 9.43 mg/dl 0.15 0.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36648 401
FHH-Chr 19BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.22 mg/dl 0.21 0.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36681 401
FHH-Chr 9BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 7 9.03 mg/dl 0.1 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36705 401
WKY/NCrl serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 9 8.4 mg/dl 0.3 0.9 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36722 401
SS/JrHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 4 135.0 U/l 16.1 32.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36733 401
Hsd:SD plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 2 22.0 mmol/l 0.0 0.0 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36845 401
SS-Chr 7BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 0.07 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19780 381
FHH-Chr 16BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19783 381
SS-Chr 20BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 0.06 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19785 381
SS-Chr 20BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 10 0.05 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19802 381
FHH-Chr 2BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 33.83 % 4.05 12.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47064 461
SS-Chr 5BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 39.65 % 4.17 12.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47072 461
SS-Chr 13BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 52.69 % 6.13 26.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47089 461
FHH-Chr 4BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 40.76 % 4.43 12.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47093 461
SS-Chr 11BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 20 post-ischemic value/pre-ischemic value x 100% 67.56 % 4.46 19.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47138 461
FHH/EurMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 47.86 % 4.55 10.18 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47173 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 14 5.52 mmHg 0.18 0.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47183 461
FHH-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.91 mmHg 0.17 0.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47188 461
FHH-Chr 10BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 5.17 mmHg 0.92 1.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47190 461
FHH-Chr 8BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 5.95 mmHg 0.18 0.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47198 461
FHH-Chr 8BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.53 mmHg 0.34 0.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47202 461
LEW/Crl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 %change=VE during 2-3 min hypoxia/control during standard conditions 127.49 % 6.13 26.03 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19301 381
GH/OmrMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 -7.83 mmHg 0.73 1.94 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19330 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 112.69 breaths/min 4.36 11.53 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18152 381
FHH-Chr 20BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 4.89 mmHg 0.29 0.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47206 461
FHH-Chr 4BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.86 mmHg 0.14 0.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47213 461
FHH-Chr 4BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.91 mmHg 0.39 1.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47215 461
SS-Chr 19BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 5.13 mmHg 0.35 1.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47217 461
SS-Chr 9BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 17 5.45 mmHg 0.17 0.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47231 461
F344/NHsd heart left ventricle wet weight controlled air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 heart left ventricle mass male 105 days 23 median 0.53 g post excision weight measurement 0 11568 102
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 90.27 % 16.16 60.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48281 461
FHH-Chr 6BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 103.69 % 12.8 40.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48283 461
FHH-Chr 2BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 78.07 % 8.12 21.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48287 461
SHR/NCrl percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 85.73 % 12.53 39.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48289 461
Hsd:SD heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 3 1.23 g 0.07 0.11 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45037 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 1 187.41 beats/min balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45077 461
FHH-Chr 6BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 157.95 beats/min 19.19 54.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45137 461
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 243.51 beats/min 26.83 80.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45142 461
SS-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 18 5.39 mmHg 0.25 1.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47233 461
SS-Chr 17BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 5.24 mmHg 0.17 0.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47244 461
SS-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.33 mmHg 0.24 0.75 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47246 461
Hsd:SD percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 49.04 % 6.43 21.32 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48117 461
SS-Chr 15BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 208.68 beats/min 8.81 23.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45152 461
FHH-Chr 4BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 233.2 beats/min 9.6 28.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45166 461
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 174.67 beats/min 14.84 46.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45171 461
SS-Chr 6BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 185.09 beats/min 10.9 32.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45181 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 11.17 ml/min/g 1.07 2.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46285 461
FHH-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 16 0.29 IU/g 0.06 0.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47422 461
FHH-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.25 IU/g 0.04 0.12 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47426 461
SS-Chr 10BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.21 IU/g 0.05 0.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47439 461
SS-Chr 12BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 82.73 % 2.36 7.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48316 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 63.71 % 11.38 39.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48319 461
FHH-Chr 1BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 93.4 % 3.73 11.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48321 461
SS-Chr 9BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 63.51 % 10.06 42.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48329 461
SS-Chr 17BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 85.66 % 3.88 11.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48337 461
FHH/EurMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 64.18 % 8.58 32.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48346 461
FHH-Chr 3BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 71.02 % 17.68 39.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48348 461
FHH-Chr 13BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 80.81 % 8.49 25.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48354 461
SS-Chr 11BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 93.01 % 3.14 13.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48356 461
SS-Chr 1BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 77.6 % 5.34 14.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48362 461
Crl:CD(SD) heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.45 IU/g 0.25 0.74 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48379 461
FHH-Chr 10BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 35.44 mmHg 11.2 22.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46410 461
FHH-Chr XBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 50.23 mmHg 4.85 13.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46417 461
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.25 mmHg 0.16 0.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47374 461
FHH-Chr 4BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 105.21 mmHg 7.47 21.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45745 461
FHH-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 132.24 mmHg 4.63 13.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45788 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 125.94 mmHg 4.36 16.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45800 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 4 8.04 ml/min/g 0.43 0.86 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46634 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 89 44.01 mmHg 2.46 23.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45336 461
SS-Chr 4BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 18 49.44 mmHg 4.09 17.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45344 461
FHH-Chr 7BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 56.92 mmHg 5.94 18.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45346 461
SS-Chr XBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 50.05 mmHg 6.02 19.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45349 461
SS/JrHsdMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 4 780.59 s 43.73 87.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45386 461
SS-Chr 18BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 632.96 s 44.45 125.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45388 461
SS-Chr 5BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 5.69 g/kg 0.26 0.81 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45618 461
FHH-Chr 19BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 7.19 g/kg 0.36 1.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45636 461
FHH/EurMcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 60 7.26 g/kg 0.19 1.44 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45649 461
SS-Chr YBN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 30 5.82 g/kg 0.21 1.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45653 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 12 5.43 g/kg 0.26 0.92 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45676 461
BN/NHsdMcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 24 4.53 g/kg 0.1 0.48 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45678 461
FHH-Chr 9BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 7.08 g/kg 0.38 1.2 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45682 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 32.0 mmHg 7.47 19.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45690 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 6 11.83 IU/g 0.85 2.09 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45703 461
SHR/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 12 139.01 mmHg 6.08 21.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45726 461
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 47.43 ml/min 3.32 11.01 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17468 381
F344/DuCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 0.29 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16035 381
FHH-Chr 6BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 8 8.7 g/kg 0.16 0.47 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45601 461
SS-Chr 10BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 5.88 g/kg 0.32 1.0 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45607 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 14 12.9 ml/min/g 0.79 2.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46639 461
FHH-Chr 8BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 12.97 ml/min/g 0.54 1.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46658 461
FHH-Chr 20BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 12.26 ml/min/g 0.48 1.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46662 461
FHH-Chr 4BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 11.71 ml/min/g 0.45 1.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46671 461
SS-Chr 14BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 19 10.65 ml/min/g 0.51 2.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46689 461
FHH-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 149.85 beats/min 16.91 41.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45211 461
SS-Chr 1BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 167.73 beats/min 17.91 53.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45217 461
GH/OmrMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 176.87 beats/min 23.98 63.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45250 461
FHH-Chr 6BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 34.04 mmHg 6.41 18.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45259 461
FHH-Chr 1BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 53.5 mmHg 6.47 20.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45296 461
FHH-Chr 17BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 5.44 ml/min/g 0.38 1.56 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44764 461
SS-Chr 20BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 23 4.83 ml/min/g 0.26 1.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44729 461
FHH-Chr 1BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 7.06 ml/min/g 0.69 2.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44733 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 7.4 ml/min/g 1.07 3.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44735 461
FHH-Chr 15BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 6.29 ml/min/g 1.13 3.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44746 461
SS-Chr 9BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 6.27 ml/min/g 0.83 3.41 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44752 461
SS-Chr 6BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 13.16 ml/min/g 0.47 1.5 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46691 461
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 9.52 ml/min/g 0.57 1.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46706 461
SS-Chr 4BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 18 10.83 ml/min/g 0.75 3.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46723 461
BN/NHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 21 16.32 ml/min/g 0.83 3.8 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46731 461
F344/DuCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 138.79 mmHg 5.41 16.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47674 461
LEW/Crl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 65.09 % 5.14 16.26 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47883 461
Hsd:SD percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 3 post-ischemic value/pre-ischemic value x 100% 81.22 % 6.92 11.99 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47887 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 5 250.62 beats/min 16.49 36.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45873 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 65.05 mmHg 23.59 40.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45906 461
LEW/Crl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 32.65 mmHg 5.01 15.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45908 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 3 68.36 mmHg 3.47 6.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45910 461
SS-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 19 27.87 IU/g 2.62 11.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45959 461
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 23.95 IU/g 2.61 7.82 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45969 461
FHH-Chr 4BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 11.57 IU/g 1.63 4.9 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46002 461
SS/JrHsdMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 89.23 % 7.34 20.75 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46037 461
SS-Chr 1BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 3.29 ml/min/g 0.2 0.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44785 461
SS-Chr 1BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 3.49 ml/min/g 0.19 0.51 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44787 461
FHH-Chr 9BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 6.32 ml/min/g 1.86 5.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44798 461
SS-Chr 18BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 44.47 % 10.09 28.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48001 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 6.53 mmHg 0.12 0.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48011 461
LE/BluGill left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 5.77 mmHg 0.29 0.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48017 461
Hsd:SD red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 16 9.08 x 10E6 cells/ul 0.18 0.71 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38194 401
FHH/EurMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 7 0.08 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38200 401
WKY/NCrl blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 9 2.29 x 1000 cells/ul 0.29 0.86 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38221 401
FHH-Chr 1BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 15 26.87 mmol/l 0.75 2.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38276 401
FHH-Chr 10BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 5.87 x 1000 cells/ul 0.41 1.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41502 401
SS/JrHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 40.8 ml/min/kg 0.92 2.42 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58071 526
F344/DuCrl fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 17 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58085 526
FHH-Chr XBN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.44 null 0.04 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58109 526
SS-Chr 13BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 11 0.42 null 0.02 0.07 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58120 526
FHH-Chr YBN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.39 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58126 526
SS-Chr 15BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.46 mg/dl 0.03 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39580 401
SS-Chr 13BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 12 0.27 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39583 401
FHH-Chr 1BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 9 0.24 mg/dl 0.03 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39602 401
FHH-Chr 17BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 6 0.25 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39624 401
SS-Chr 2BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 15 0.5 x 1000 cells/ul 0.06 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39701 401
FHH-Chr 5BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.18 x 1000 cells/ul 0.05 0.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39704 401
SS-Chr 6BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 7 0.64 x 1000 cells/ul 0.2 0.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39712 401
GH/OmrMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 12 0.16 x 1000 cells/ul 0.03 0.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39718 401
FHH/EurMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 16 0.22 x 1000 cells/ul 0.05 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39726 401
FHH-Chr 19BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.16 x 1000 cells/ul 0.05 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39731 401
FHH-Chr 11BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 9 0.35 x 1000 cells/ul 0.07 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39747 401
BN/NHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 12 0.08 x 1000 cells/ul 0.04 0.14 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39753 401
SS-Chr 12BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 7.08 x 1000 cells/ul 0.39 1.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41524 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 11 4.3 x 1000 cells/ul 0.57 1.89 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41527 401
SS-Chr 7BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 11 6.67 x 1000 cells/ul 0.44 1.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41548 401
FHH-Chr 17BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 6 4.14 x 1000 cells/ul 0.49 1.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41551 401
Crl:CD(SD) mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 32.72 g/dl 0.15 0.45 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42733 401
SS-Chr 7BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 11 80.64 U/l 7.12 23.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42815 401
FHH-Chr 13BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 85.4 U/l 3.91 12.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42829 401
SS-Chr XBN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 11 85.27 U/l 5.09 16.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42839 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 15 37.75 degrees C 0.08 0.31 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16558 381
SHR/NCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 20 37.45 degrees C 0.13 0.58 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16566 381
FHH-Chr YBN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 21 36.5 degrees C 0.62 2.84 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16585 381
FHH-Chr 11BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 15.6 mmol/l 1.08 3.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38335 401
SS-Chr 14BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 18 0.52 null 0.02 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58145 526
FHH-Chr YBN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 11 989.55 s 38.56 127.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49312 461
FHH-Chr 1BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 900.59 s 38.21 120.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49314 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 12 955.17 s 41.31 143.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49318 461
SS-Chr 6BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 883.2 s 27.76 87.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49337 461
GH/OmrMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 875.15 s 114.44 361.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49343 461
FHH-Chr 17BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 17 941.65 s 25.06 103.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49345 461
SS-Chr 16BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 22 769.16 s 40.2 188.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49353 461
SS-Chr YBN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 29 907.97 s 40.12 216.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49364 461
SS/JrHsdMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 17 742.79 s 32.97 135.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49370 461
FHH-Chr 9BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 918.0 s 46.36 139.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49374 461
SS-Chr 20BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 26 32.06 g/dl 0.08 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39779 401
F344/DuCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 93.02 mmHg 7.25 22.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49275 461
LE/BluGill left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 103.04 mmHg 6.72 20.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49283 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 14 795.77 s 51.48 192.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49285 461
FHH-Chr XBN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 1015.0 s 39.65 112.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49295 461
SS-Chr 20BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 23 713.31 s 21.92 105.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49301 461
SS/JrHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 9 3.56 g/dl 0.11 0.34 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42962 401
Hsd:SD serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 18 4.34 g/dl 0.07 0.3 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42965 401
GH/OmrMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 116.4 % 4.08 11.55 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 54303 381
SS-Chr 16BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 134.29 % 5.99 21.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54384 381
FHH-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 126.53 % 7.54 23.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54389 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 130.03 % 5.02 19.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54394 381
SS-Chr 16BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 7 55.66 % 1.06 2.8 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38357 401
Hsd:SD methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 30.66 ml/min/kg 2.45 5.99 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58430 526
FHH/EurMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 7 1.69 g/dl 0.06 0.16 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Dyets 39964 401
FHH/EurMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 7 1.8 g/dl 0.07 0.18 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Dyets 39967 401
FHH-Chr 16BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 20 166.7 g 4.3 19.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49528 461
FHH/EurMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 17 127.0 g 8.9 36.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49532 461
FHH-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 9 77.0 g 11.3 33.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49534 461
FHH-Chr 19BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 111.6 g 6.9 21.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49538 461
SS-Chr 18BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 15 127.5 g 4.1 16.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49562 461
FHH-Chr 11BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 136.0 g 5.1 16.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49567 461
LEW/Crl heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 40.2 mmHg 2.67 8.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49588 461
FHH-Chr 12BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 11 0.91 x 1000 cells/ul 0.11 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43215 401
Hsd:SD serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 5 105.0 mmol/l 2.47 5.52 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38374 401
FHH-Chr 6BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 169.0 mg/dl 10.15 32.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38519 401
SS-Chr 13BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 12 0.04 x 1000 cells/ul 0.01 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41654 401
SS-Chr 12BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41668 401
SS-Chr 9BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 15 0.04 x 1000 cells/ul 0.01 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41684 401
FHH-Chr 11BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 9 0.06 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41720 401
Hsd:SD plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 3 0.37 mg/dl 0.12 0.21 automated plasma creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41731 401
FHH-Chr 6BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.03 mmHg-1 0.0 0.0 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58477 526
FHH-Chr 9BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 6 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58570 526
F344/DuCrl methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 0.31 null 0.02 0.07 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58575 526
LEW/Crl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 61.88 % 1.0 2.84 microhematocrit tube assay with visual assessment 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58583 526
WKY/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 59.44 % 1.32 3.73 microhematocrit tube assay with visual assessment 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58589 526
FHH-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 78.91 mmHg 9.3 24.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49880 461
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 148.83 % 5.57 17.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53734 381
FHH-Chr 15BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 6.29 g/kg 0.36 1.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45589 461
FHH-Chr 5BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 6.59 g/kg 0.15 0.48 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45595 461
FHH-Chr 4BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 57.65 mmHg 2.97 7.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46433 461
SS-Chr 19BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 55.28 mmHg 4.02 11.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46439 461
SS-Chr 16BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 16 61.16 mmHg 3.29 13.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46474 461
Hsd:SD time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 905.67 s 30.38 96.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49664 461
FHH-Chr 2BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 7 9.12 % 1.74 4.61 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49690 461
SS-Chr 5BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 7 20.24 % 3.13 8.28 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49696 461
FHH-Chr 18BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 12.95 % 4.63 13.9 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49708 461
SS-Chr 18BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 9 30.19 % 9.52 28.56 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49712 461
SS-Chr 10BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 9 23.64 % 4.18 12.53 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49727 461
FHH-Chr 17BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 17 10.56 % 2.37 9.77 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49746 461
SS-Chr 20BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 26 0.77 x 1000 cells/ul 0.06 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43226 401
SS-Chr 15BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.49 x 1000 cells/ul 0.06 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43228 401
FHH-Chr 13BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.61 x 1000 cells/ul 0.07 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43283 401
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 108.25 % 6.21 19.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54544 381
SS-Chr 16BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 105.38 % 5.26 13.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54552 381
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 116.96 % 6.82 20.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54555 381
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 137.4 % 6.97 26.99 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53541 381
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 103.49 % 5.79 15.32 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53571 381
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 105.28 % 4.19 16.23 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53574 381
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 117.74 % 11.68 26.11 stop flow air displacement plethysmography 0 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53612 381
FHH-Chr 16BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 9 142.33 mg/dl 2.58 7.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38581 401
SS-Chr 1BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 6 133.0 mg/dl 8.83 21.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38600 401
FHH-Chr 11BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 9 164.22 mg/dl 9.42 28.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38603 401
FHH-Chr 9BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 5 136.6 mg/dl 11.78 26.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38606 401
FHH-Chr 9BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 7 139.71 mg/dl 5.45 14.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38611 401
SS/JrHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 4 83.0 U/l 9.03 18.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 43411 401
FHH-Chr 8BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.93 g 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45406 461
SS-Chr 13BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 19 1.01 g 0.03 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45417 461
FHH-Chr 15BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 0.75 g 0.06 0.17 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45444 461
FHH-Chr XBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 96.16 mmHg 6.6 17.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49884 461
FHH-Chr XBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 92.96 mmHg 8.26 23.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49888 461
SS-Chr 20BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 19 108.18 mmHg 2.97 12.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49890 461
SS-Chr 15BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 97.71 mmHg 5.39 14.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49892 461
FHH-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 100.96 mmHg 4.91 14.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49898 461
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 82.79 mmHg 8.09 21.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49902 461
SS-Chr 6BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 124.44 mmHg 3.19 9.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49921 461
GH/OmrMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 135.34 mmHg 10.99 34.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49932 461
FHH-Chr 17BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 17 92.9 mmHg 7.5 30.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49934 461
FHH-Chr 19BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 88.47 mmHg 4.92 15.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49944 461
FHH-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 73.83 mmHg 7.92 19.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49951 461
BN/NHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 24 110.81 mmHg 3.12 15.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49965 461
LEW/Crl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 242.22 beats/min 5.72 17.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49971 461
Crl:CD(SD) heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 250.69 beats/min 6.17 19.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49974 461
SS-Chr 5BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 36.13 mmHg 2.72 7.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49995 461
SS-Chr 15BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 34.22 mmHg 3.05 9.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50001 461
FHH-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 11 2.18 mg/kg 0.48 1.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58897 526
SS-Chr 9BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.6 mg/kg 0.38 1.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58940 526
FHH-Chr 19BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 6.23 % 1.88 5.95 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49754 461
FHH-Chr 7BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 3.66 % 1.3 4.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49774 461
Hsd:SD serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 3 20.67 mg/dl 0.33 0.58 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39987 401
FHH-Chr 20BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41874 401
FHH-Chr 18BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41876 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 9 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41887 401
SS-Chr 17BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.13 mg/dl 0.02 0.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41915 401
SS-Chr 20BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 25 0.32 IU/g 0.03 0.16 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47473 461
SS-Chr 4BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 19 0.35 IU/g 0.05 0.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47498 461
FHH-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.41 IU/g 0.07 0.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47500 461
SS-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 2 0.22 IU/g 0.04 0.06 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47504 461
FHH-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.29 IU/g 0.04 0.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47508 461
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 16 262.5 beats/min 10.58 42.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47567 461
SS-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 19 244.69 beats/min 7.41 32.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47594 461
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 265.22 beats/min 8.38 25.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47596 461
SS-Chr 19BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 262.16 beats/min 7.61 22.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47602 461
SS-Chr 19BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 265.92 beats/min 7.32 23.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47604 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 12 259.78 beats/min 7.76 26.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47606 461
FHH-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 241.65 beats/min 7.55 23.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47612 461
FHH-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 18 249.24 beats/min 4.69 19.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47625 461
SS-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 255.1 beats/min 12.21 40.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47627 461
FHH/EurMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 7 0.48 x 1000 cells/ul 0.13 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40387 401
BN/NHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 18 1.44 mg/kg 0.17 0.71 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58984 526
SHR/NCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 25 227.4 g 2.7 13.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59056 526
FHH-Chr 8BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 168.4 g 2.8 8.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59067 526
FHH-Chr 5BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 147.2 g 9.5 30.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59097 526
SS-Chr 10BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 186.9 g 4.7 14.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59102 526
FHH-Chr 16BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 159.5 g 9.5 30.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59105 526
FHH-Chr 17BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 181.0 g 4.5 14.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59108 526
SS-Chr 11BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 20 164.4 g 4.9 22.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59124 526
FHH-Chr 11BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 166.0 g 4.8 15.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59135 526
FHH-Chr 9BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 7 1.7 g/dl 0.15 0.39 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40631 401
WKY/NCrl blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 9 0.23 x 1000 cells/ul 0.03 0.08 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40696 401
FHH-Chr 12BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 11 53.82 U/l 2.48 8.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40705 401
FHH-Chr XBN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 106.75 U/l 18.71 52.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40710 401
FHH-Chr 18BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 56.8 U/l 2.26 7.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40724 401
FHH-Chr YBN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 9 68.78 U/l 7.69 23.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40727 401
SS-Chr 9BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 20 0.4 null 0.02 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58770 526
SS-Chr 3BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 14 0.41 null 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58794 526
LEW/Crl methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 16.08 ml/min/kg 0.66 1.85 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58835 526
FHH-Chr 4BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 33.13 mmHg 5.18 14.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50013 461
FHH-Chr 19BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 30.7 mmHg 2.91 9.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50049 461
SS/JrHsdMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 17 47.0 mmHg 2.71 11.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50068 461
SS-Chr 18BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 1040.41 s 26.35 74.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50097 461
FHH/EurMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 5 1453.88 s 54.23 121.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50101 461
SS-Chr 20BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 2.95 g/dl 0.12 0.33 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40498 401
Hsd:SD blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 16 4.77 x 1000 cells/ul 0.4 1.59 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40515 401
SS-Chr 18BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 2.25 g/dl 0.06 0.2 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40564 401
SS-Chr 10BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 40.9 U/l 3.09 9.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40754 401
FHH-Chr 16BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 9 43.22 U/l 3.41 10.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40757 401
FHH-Chr 17BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 121.83 mmHg 4.63 16.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48672 461
FHH-Chr 19BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 87.07 mmHg 5.45 17.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48680 461
SS-Chr XBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 104.75 mmHg 8.93 28.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48692 461
SS-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 22.89 % 4.38 12.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48711 461
FHH-Chr 18BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 83.12 % 5.23 13.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48766 461
FHH-Chr 1BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 59.13 % 8.47 26.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48771 461
SS-Chr 17BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 92.83 % 4.27 12.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48798 461
FHH-Chr 3BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 87.4 % 20.48 50.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48819 461
SS-Chr YBN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 25 post-ischemic value/pre-ischemic value x 100% 68.76 % 3.78 18.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48821 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 15 230.48 beats/min 12.06 46.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47633 461
SS-Chr 4BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 19 276.04 beats/min 6.73 29.34 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47656 461
FHH-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 255.48 beats/min 6.01 18.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47663 461
SHR/NCrl percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 32.63 % 4.46 13.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48521 461
FHH-Chr XBN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 41.86 % 6.66 18.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48527 461
GH/OmrMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 54.64 % 10.4 32.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48571 461
SS-Chr 17BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 43.89 % 4.08 12.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48574 461
FHH/EurMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 32.96 % 6.26 23.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48578 461
FHH-Chr 3BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 44.17 % 12.84 31.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48590 461
SS-Chr 1BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 19.45 % 2.89 8.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48594 461
SS-Chr 1BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 22.45 % 4.2 11.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48596 461
FHH-Chr XBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 109.41 mmHg 7.01 19.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48620 461
SS-Chr 13BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 13 126.91 mmHg 7.75 27.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48636 461
SS-Chr 19BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 96.55 mmHg 5.34 15.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48644 461
FHH-Chr 14BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 82.31 mmHg 13.08 26.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48655 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.37 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58723 526
SS-Chr 5BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.44 null 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58728 526
SS-Chr 15BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 14 0.43 null 0.02 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58737 526
FHH-Chr 20BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.52 null 0.04 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58742 526
SS-Chr 18BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 29 0.33 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58750 526
LEW/Crl methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 11.8 ml/min/kg 0.39 1.1 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59861 526
Crl:CD(SD) methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 7.65 ml/min/kg 0.45 1.43 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59864 526
FHH-Chr 6BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.82 g/dl 0.04 0.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42222 401
FHH-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 11 55.15 % 0.58 1.93 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38982 401
SS-Chr 10BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 57.21 % 0.63 1.98 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59286 526
SS-Chr 14BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 17 53.46 % 0.75 3.1 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59289 526
F344/DuCrl plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 18 24.44 mmol/l 0.63 2.66 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37554 401
SS-Chr 20BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 9.53 mg/dl 0.59 1.66 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37571 401
FHH-Chr 8BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 7.9 mg/dl 0.19 0.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37595 401
SS-Chr 13BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 12 8.2 mg/dl 0.19 0.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37601 401
FHH-Chr 18BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 8.48 mg/dl 0.18 0.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37604 401
FHH-Chr YBN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 9 10.03 mg/dl 0.26 0.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37607 401
FHH-Chr 1BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 9 8.26 mg/dl 0.26 0.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37620 401
SS-Chr 10BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 8.89 mg/dl 0.24 0.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37623 401
FHH-Chr 13BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 60.43 fl 0.22 0.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38804 401
SS-Chr 11BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 15 61.13 fl 0.53 2.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38810 401
FHH/EurMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 7 6.6 mmol/l 0.41 1.09 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 38829 401
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 16 55.51 % 1.05 4.2 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38853 401
SS-Chr 9BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 17 16.47 mmol/l 0.62 2.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42096 401
SS-Chr 10BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 22.5 mmol/l 0.54 1.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42102 401
FHH-Chr 17BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 6 22.17 mmol/l 1.78 4.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42110 401
FHH-Chr 16BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 9 20.67 mmol/l 0.83 2.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42113 401
BN/NHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 20 16.0 mmol/l 0.42 1.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42140 401
FHH-Chr 9BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 7 17.43 mmol/l 0.69 1.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42143 401
FHH-Chr 10BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 7 51.44 % 0.94 2.5 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59250 526
FHH-Chr 10BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 53.31 % 0.37 1.03 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59256 526
FHH-Chr 8BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 52.84 % 0.8 2.53 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59258 526
FHH-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 49.08 % 0.91 2.87 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59267 526
FHH-Chr YBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 9 57.14 % 0.74 2.23 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59270 526
SS-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 55.44 % 0.73 2.06 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59278 526
FHH/EurMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 938.97 s 47.32 125.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48923 461
SS-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 11 1.2 mg/kg 0.21 0.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58962 526
FHH-Chr XBN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 110.5 mmol/l 0.5 1.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39113 401
FHH-Chr 16BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 9 3.82 g/dl 0.08 0.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42276 401
BN/NHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 17 3.62 g/dl 0.05 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42312 401
LEW/Crl serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 185.6 U/l 14.19 44.88 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42347 401
FHH/EurMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 7 3.6 g/dl 0.07 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42397 401
FHH-Chr XBN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.14 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59543 526
SS-Chr 18BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 1028.19 s 37.92 141.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50244 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 12 1044.68 s 73.52 254.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50251 461
SS-Chr 10BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1044.7 s 36.54 115.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50267 461
GH/OmrMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1222.82 s 115.16 364.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50271 461
FHH/EurMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 15 1229.89 s 43.51 168.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50278 461
FHH-Chr 3BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 1206.6 s 46.52 104.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50280 461
SS-Chr 11BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 21 1024.95 s 25.42 116.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50288 461
FHH/EurMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 11.82 ml/min/kg 0.95 2.68 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 57568 526
FHH-Chr 8BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 16.45 ml/min/kg 0.9 2.85 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57603 526
FHH-Chr 5BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 14.93 ml/min/kg 1.04 2.95 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57633 526
SS-Chr 14BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 17 53.48 % 0.75 3.11 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39023 401
SS-Chr 10BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 55.58 % 0.77 2.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39031 401
FHH-Chr 1BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 13 23.15 mg/dl 0.86 3.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40843 401
SS-Chr 14BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 17 21.47 mg/dl 0.87 3.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40860 401
SS-Chr 11BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 15 22.4 mg/dl 0.92 3.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40893 401
SS-Chr 16BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 13 6.23 x 1000 cells/ul 0.66 2.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40984 401
SS-Chr XBN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 11 7.15 x 1000 cells/ul 0.57 1.89 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40995 401
LE/BluGill heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 14 0.41 null 0.02 0.06 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59971 526
SS-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 7 52.26 % 0.74 1.95 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39047 401
SS-Chr 11BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 15 52.9 % 0.89 3.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39056 401
SS/JrHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 4 21.25 mmol/l 1.75 3.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39086 401
SS-Chr 16BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 15 110.33 mmol/l 1.14 4.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39172 401
SS-Chr XBN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 11 108.27 mmol/l 0.75 2.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39186 401
FHH-Chr 7BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 108.3 mmol/l 0.6 1.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39194 401
FHH-Chr 12BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 12 8.97 x 10E6 cells/ul 0.1 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39222 401
FHH-Chr 2BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 8.98 x 10E6 cells/ul 0.18 0.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39224 401
SS-Chr 15BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 8.74 x 10E6 cells/ul 0.11 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39241 401
SS-Chr 12BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 8.88 x 10E6 cells/ul 0.1 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39258 401
SS-Chr 2BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 9.16 x 10E6 cells/ul 0.11 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39260 401
FHH-Chr 1BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 9 9.51 x 10E6 cells/ul 0.1 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39263 401
FHH-Chr 14BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 8.87 x 10E6 cells/ul 0.21 0.61 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39268 401
SS-Chr 4BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 18 17.13 ml/min/kg 1.39 5.91 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57673 526
BN/NHsdMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 24 16.73 ml/min/kg 1.4 6.87 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57676 526
LEW/Crl calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.14 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57687 526
SS-Chr 16BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 6 0.07 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Dyets 57758 526
F344/DuCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 13 3.49 mg/kg 0.6 2.15 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57771 526
SS-Chr 17BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 16.52 g/dl 0.21 0.61 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38015 401
FHH-Chr 3BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 16.71 g/dl 0.39 1.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38032 401
SS/JrHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 17.94 g/dl 0.12 0.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38040 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.26 mmol/l 0.11 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38056 401
FHH-Chr 8BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.45 mmol/l 0.18 0.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38067 401
FHH-Chr 1BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 5.31 mmol/l 0.11 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38081 401
SS-Chr 12BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 5.09 mmol/l 0.23 0.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38087 401
SS-Chr 2BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.29 mmol/l 0.08 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38089 401
SS-Chr 10BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.21 mmol/l 0.19 0.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38106 401
FHH-Chr 16BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 9 4.42 mmol/l 0.16 0.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38109 401
Crl:CD(SD) partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 5 28.81 mmHg 1.6 3.57 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16365 381
SS/JrHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 7 60.71 U/l 8.35 22.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 41159 401
SS-Chr 10BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.16 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59576 526
SS-Chr 11BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 0.13 mmHg x min x kg x ml-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59612 526
FHH-Chr 9BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.14 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59623 526
GH/OmrMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 34 1.34 g/kg 0.03 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59701 526
FHH-Chr 13BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.47 g/kg 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59717 526
BN/NHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 32 1.57 g/kg 0.03 0.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59736 526
F344/DuCrl FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 13 54.81 ml/min/kg 3.83 13.8 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60136 526
Hsd:SD mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 5 31.4 g/dl 1.02 2.29 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42502 401
FHH-Chr 20BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 18.9 pg 0.09 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42554 401
SS-Chr 19BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 19.29 pg 0.24 0.75 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42565 401
SS-Chr 2BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 19.96 pg 0.15 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42568 401
FHH-Chr 5BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 16.01 g/dl 0.2 0.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37998 401
FHH/EurMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 11 13.1 ml/min/kg 0.52 1.72 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57852 526
FHH/EurMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 53 20.85 ml/min/kg 1.06 7.71 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57863 526
SS-Chr 1BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 27.15 ml/min/kg 0.47 1.5 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57868 526
SS-Chr 4BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 22 22.33 ml/min/kg 0.82 3.85 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57871 526
FHH-Chr 6BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 141.7 mmol/l 0.58 1.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39376 401
FHH-Chr 10BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 139.75 mmol/l 0.8 2.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39381 401
FHH-Chr XBN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 142.88 mmol/l 1.04 2.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39384 401
SS-Chr 12BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 142.63 mmol/l 0.73 2.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39409 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 11 144.55 mmol/l 0.65 2.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39412 401
SS-Chr 9BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 17 143.24 mmol/l 1.0 4.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39422 401
SS-Chr 10BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 140.5 mmol/l 0.5 1.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39428 401
SS/JrHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.22 x 1000 cells/ul 0.05 0.16 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39538 401
GK heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 5 366.0 beats/min 17.0 38.01 vascular transducer tipped catheter 0.0 0 103041 2784
GK heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 344.0 beats/min 11.0 29.1 vascular transducer tipped catheter 0.0 0 103050 2784
SS.BN-(D12Arb13-D12Rat79)/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.47 ml 0.02 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15219 381
FHH-Chr 6BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.31 ml 0.04 0.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15221 381
FHH-Chr 6BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 0.33 ml 0.03 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15222 381
FHH-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.24 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15225 381
SS-Chr 20BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 0.34 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15235 381
SS-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.29 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15254 381
SS-Chr 16BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 6 137.58 breaths/min 6.54 16.02 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15582 381
SS-Chr 16BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 0.38 ml 0.01 0.02 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14630 381
FHH/EurMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 9 113.88 mmHg 7.4 22.19 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14662 381
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 109.6 mmHg 5.05 13.36 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14665 381
GH/OmrMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 0.35 ml 0.02 0.05 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14625 381
SS-Chr 2BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 12 123.29 mmHg 4.45 15.41 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14378 381
GH/OmrMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 141.2 mmHg 6.68 17.68 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14413 381
LEW/Crl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 1 0.32 ml stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15266 381
FHH-Chr 5BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.28 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15269 381
FHH-Chr 15BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.3 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15273 381
FHH-Chr 17BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.28 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15280 381
GH/OmrMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 6 0.38 ml 0.05 0.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15283 381
SS-Chr 7BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.3 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15284 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 0.36 ml 0.01 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15286 381
SS-Chr 16BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 0.39 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15292 381
FHH-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.21 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15298 381
SS-Chr 1BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.28 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15302 381
FHH-Chr 14BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 110.08 % 5.25 16.59 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54018 381
FHH-Chr 5BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 91.46 % 5.65 17.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54022 381
SS-Chr 17BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 103.23 % 5.87 18.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54033 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 111.27 % 4.17 15.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54041 381
FHH-Chr 19BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 101.79 % 3.87 14.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54043 381
SS-Chr XBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 96.62 % 4.56 15.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54055 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 106.25 % 3.64 12.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54057 381
FHH-Chr 7BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 120.17 % 8.5 28.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54063 381
SS-Chr XBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 106.84 % 6.29 23.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54065 381
F344/DuCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 98.76 % 1.9 7.62 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54199 381
FHH-Chr 5BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 145.21 % 6.99 22.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13716 381
SS-Chr 6BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 %change=VE during 2-3 min hypoxia/control during standard conditions 145.54 % 7.42 26.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13719 381
FHH-Chr 14BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 141.18 % 7.7 24.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13722 381
FHH-Chr 16BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 %change=VE during 2-3 min hypoxia/control during standard conditions 142.32 % 8.52 31.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13724 381
SS-Chr 3BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 %change=VE during 2-3 min hypoxia/control during standard conditions 131.71 % 6.41 22.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13737 381
FHH-Chr 19BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 %change=VE during 2-3 min hypoxia/control during standard conditions 141.91 % 7.41 27.72 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13738 381
FHH-Chr 13BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 150.52 % 10.57 33.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13740 381
FHH-Chr 3BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 139.2 % 11.85 37.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13745 381
SS/JrHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 74 %change=VE during 2-3 min hypoxia/control during standard conditions 149.98 % 2.94 25.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13748 381
SS-Chr 4BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 %change=VE during 2-3 min hypoxia/control during standard conditions 149.77 % 6.59 25.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13756 381
LEW/Crl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 %change=VE during7-9 min hypoxia/control during standard conditions 118.79 % 6.09 25.84 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17334 381
Crl:CD(SD) percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 %change=VE during7-9 min hypoxia/control during standard conditions 123.49 % 5.27 18.99 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17335 381
F344/DuCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 %change=VE during7-9 min hypoxia/control during standard conditions 128.94 % 5.94 25.2 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17341 381
LE/BluGill percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 %change=VE during7-9 min hypoxia/control during standard conditions 144.14 % 5.01 18.07 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17342 381
SS-Chr 20BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 %change=VE during 2-3 min hypoxia/control during standard conditions 156.3 % 7.7 28.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13691 381
SS-Chr 13BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 156.19 % 12.44 37.33 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13692 381
SS-Chr 19BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 148.59 % 14.22 42.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13702 381
SS-Chr 2BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 %change=VE during 2-3 min hypoxia/control during standard conditions 138.21 % 7.07 25.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13707 381
FHH-Chr 15BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 141.45 % 6.54 20.67 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13708 381
SS-Chr 4BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 9 131.85 mmHg 3.76 11.28 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14368 381
SS-Chr 2BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 10 121.23 mmHg 6.91 21.84 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14371 381
BN/NHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 10 121.37 mmHg 4.32 13.66 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14375 381
SS-Chr 13BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 7.54 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17063 381
FHH-Chr 20BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 7.5 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17065 381
FHH-Chr 1BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 7.5 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17076 381
Hsd:SD mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 2 115.72 mmHg 14.37 20.32 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13876 381
LEW/Crl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 16 105.59 mmHg 2.75 11.01 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13877 381
LEW/Crl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 16 95.21 mmHg 5.41 21.65 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13882 381
FHH-Chr 6BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 0.33 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13912 381
SS-Chr 5BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.29 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13918 381
FHH-Chr XBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.25 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13923 381
FHH-Chr 12BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 12 30.63 mmHg 0.54 1.88 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17214 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 10 24.78 mmHg 1.28 4.05 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17216 381
FHH-Chr 6BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 1 33.0 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17217 381
SS-Chr 9BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 11 30.48 mmHg 0.99 3.28 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17220 381
FHH-Chr 19BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 9 28.89 mmHg 1.3 3.91 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17242 381
SS-Chr 16BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 10 26.91 mmHg 0.83 2.63 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17244 381
FHH-Chr 20BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 7 29.99 mmHg 0.74 1.95 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17257 381
SS-Chr 11BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 6 26.31 mmHg 1.01 2.47 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17260 381
SS-Chr 12BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 3 23.68 mmHg 2.87 4.98 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17276 381
FHH-Chr 11BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 5 25.85 mmHg 2.25 5.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17277 381
SS-Chr 12BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 3 23.18 mmHg 0.55 0.96 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17283 381
SS-Chr 15BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.32 ml 0.03 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13927 381
FHH-Chr 1BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 18 0.37 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13938 381
FHH-Chr 15BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.34 ml 0.04 0.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13951 381
FHH-Chr 5BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.31 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13953 381
SS-Chr 6BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 0.48 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13962 381
FHH-Chr 17BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.31 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13970 381
SS-Chr 1BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.31 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13994 381
FHH-Chr 9BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.22 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14000 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 0.25 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14003 381
LE/BluGill tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 0.37 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14017 381
SHR/NCrl percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 152.97 % 9.67 29.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14034 381
SS-Chr 16BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 %change=VE during 2-3 min hypoxia/control during standard conditions 173.74 % 15.72 41.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14036 381
F344/NHsd mean pulmonary arterial blood pressure controlled air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 pulmonary arterial blood pressure trait male 105 days 23 median 27.0 mmHg vascular indwelling catheter method pulmonary artery 0 0 11566 102
FHH-Chr 18BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19803 381
F344/DuCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 40.7 ml/min 1.66 6.65 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19719 381
WKY/NCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 20 44.59 ml/min 2.73 12.22 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19723 381
SS-Chr 14BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 0.04 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19765 381
SS-Chr 6BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 10 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19767 381
FHH-Chr 12BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 0.04 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19768 381
FHH-Chr 16BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 4 0.05 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19771 381
SS-Chr 17BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 2 0.03 null 0.0 0.0 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19775 381
SS-Chr 5BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 2 0.02 null 0.03 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19782 381
FHH-Chr XBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 126.49 % 6.74 21.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53747 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 49 121.35 % 3.9 27.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53754 381
FHH-Chr 8BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 122.51 % 6.07 20.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53755 381
SS-Chr 13BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 129.51 % 5.08 16.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53761 381
SS-Chr 19BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 131.78 % 14.78 44.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53777 381
SS-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 117.42 % 9.12 25.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53779 381
FHH-Chr 15BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 128.03 % 11.54 36.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53782 381
FHH-Chr 14BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 104.41 % 4.44 14.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53785 381
SS-Chr 14BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 129.95 % 6.19 19.57 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53786 381
SS-Chr 9BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 112.95 % 6.92 21.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53788 381
SS-Chr 14BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 127.84 % 6.45 22.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53790 381
SS-Chr 9BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 17 118.34 % 6.01 24.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53791 381
SS-Chr 6BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 134.0 % 6.36 22.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53792 381
FHH-Chr 17BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 109.96 % 5.04 16.71 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53799 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 125.26 % 5.54 17.53 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53804 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 14 123.03 % 6.72 25.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53808 381
SS-Chr 11BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 116.96 % 7.35 23.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53815 381
SS-Chr XBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 129.41 % 5.75 19.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53822 381
SS-Chr 1BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 104.83 % 7.61 24.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53823 381
FHH-Chr 11BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 118.72 % 5.88 16.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53826 381
FHH-Chr 9BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 125.6 % 7.19 22.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53829 381
FHH-Chr 9BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 127.7 % 7.46 22.39 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53833 381
FHH-Chr 1BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 18 106.74 % 3.08 13.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54004 381
FHH-Chr 4BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 102.32 % 8.33 30.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54005 381
FHH-Chr 4BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 100.89 % 5.83 20.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54007 381
SS-Chr 19BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 115.32 % 8.1 22.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54008 381
SS-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 101.67 % 6.97 19.72 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54012 381
Crl:CD(SD) body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 37.45 degrees C 0.1 0.35 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19992 381
F344/DuCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 16 37.38 degrees C 0.12 0.46 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19993 381
F344/DuCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 18 37.17 degrees C 0.17 0.72 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19998 381
FHH-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 105.47 % 3.84 16.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53868 381
FHH-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 107.2 % 7.1 23.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53874 381
GH/OmrMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 101.0 % 3.6 9.53 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53877 381
SS-Chr 5BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 112.01 % 9.49 28.47 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53881 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 113.88 % 4.92 19.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53882 381
FHH-Chr 20BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 116.72 % 5.29 14.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53896 381
SS-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 122.61 % 9.52 26.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53911 381
FHH-Chr 1BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 16 108.51 % 3.5 14.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53912 381
FHH-Chr 15BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 103.68 % 3.99 11.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53925 381
SS-Chr 7BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 112.18 % 3.48 10.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53930 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 116.55 % 8.35 26.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53936 381
FHH-Chr 19BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 106.92 % 4.07 15.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53942 381
SS-Chr 1BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 131.61 % 5.66 17.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53952 381
SS-Chr 1BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 121.81 % 5.4 17.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53955 381
FHH-Chr 6BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 102.56 % 6.02 19.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53971 381
FHH-Chr 10BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 100.68 % 4.95 15.67 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53977 381
LEW/Crl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 1 94.65 % stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 53981 381
FHH-Chr XBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 90.4 % 4.08 12.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53986 381
FHH-Chr 8BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 96.77 % 7.6 25.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53988 381
SS-Chr 15BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 101.55 % 5.26 16.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53991 381
SS-Chr 13BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 116.4 % 9.12 28.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53994 381
F344/DuCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 -5.03 mmHg 0.92 2.26 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20988 381
FHH/EurMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 5 7.5 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20114 381
SS-Chr 16BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 5 7.47 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20117 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 57.94 ml/min 5.35 18.53 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20126 381
FHH-Chr 13BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 9 0.04 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19798 381
SS-Chr 11BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19804 381
SS-Chr 18BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 9 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19809 381
SS-Chr 18BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19813 381
SS-Chr 19BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 1 0.04 null automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19823 381
FHH-Chr 1BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19831 381
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 36.26 ml/min 3.77 9.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20703 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 33.17 ml/min 1.96 5.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20706 381
SS-Chr 1BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 6 133.0 U/l 1.98 4.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36449 401
FHH-Chr 11BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 9 421.67 U/l 17.79 53.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36452 401
BN/NHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 20 178.3 U/l 5.17 23.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36457 401
WKY/NCrl serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 9 71.44 mg/dl 3.44 10.31 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36462 401
LE/BluGill serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 9 132.78 mg/dl 4.93 14.79 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36467 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 14 5.91 g/dl 0.11 0.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36948 401
FHH-Chr 12BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 11 5.87 g/dl 0.06 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36953 401
FHH-Chr 2BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 5.28 g/dl 0.08 0.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36954 401
SS-Chr 20BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 27 6.13 g/dl 0.07 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36964 401
FHH-Chr 8BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.39 g/dl 0.08 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36967 401
SS-Chr 4BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 37.22 ml/min 2.8 9.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18734 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 50.79 ml/min 3.97 13.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18735 381
SS-Chr 4BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 36.11 ml/min 2.19 8.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18738 381
SS-Chr XBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 33.35 ml/min 2.19 8.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18743 381
SS-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 5 491.55 beats/min 15.67 35.05 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18756 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 424.61 beats/min 10.82 28.62 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18760 381
LEW/Crl mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 9 57.28 fl 0.34 1.01 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36286 401
LE/BluGill mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 9 60.34 fl 0.54 1.63 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36290 401
F344/DuCrl mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 12 57.53 fl 0.24 0.82 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36293 401
Hsd:SD serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 3 7.6 mg/dl 1.69 2.92 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36296 401
SS-Chr 16BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 7 140.86 mmol/l 0.51 1.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36337 401
SS/JrHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 7 138.86 mmol/l 1.14 3.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36339 401
Hsd:SD serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 5 6.16 g/dl 0.19 0.43 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36342 401
Hsd:SD serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 3 5.33 g/dl 0.67 1.15 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36343 401
F344/DuCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 14 59.31 % 0.74 2.77 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36347 401
Crl:CD(SD) hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 9 51.56 % 1.43 4.29 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36348 401
WKY/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 9 58.87 % 1.3 3.89 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36351 401
WKY/NCrl mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 18.8 pg 0.24 0.71 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36361 401
F344/DuCrl mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 18.54 pg 0.12 0.4 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36362 401
SHR/NCrl serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 20 327.95 U/l 16.2 72.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36373 401
FHH-Chr 1BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 15 390.33 U/l 17.97 69.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36394 401
SS-Chr 12BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 248.75 U/l 15.9 44.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36400 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 11 214.82 U/l 9.6 31.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36403 401
SS-Chr 2BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 15 249.33 U/l 8.98 34.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36406 401
SS-Chr 10BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 254.2 U/l 23.34 73.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36408 401
SS-Chr 14BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 20 202.25 U/l 12.03 53.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36415 401
FHH-Chr 14BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 405.75 U/l 24.89 70.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36420 401
SS-Chr 7BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 11 279.0 U/l 15.14 50.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36424 401
SS-Chr 7BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 12 144.83 U/l 6.04 20.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36429 401
LE/BluGill minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 53.64 ml/min 1.95 7.03 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18971 381
GH/OmrMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 7 50.69 mmHg 0.76 2.0 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18979 381
Crl:CD(SD) serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 9 5.88 g/dl 0.12 0.35 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36263 401
WKY/NCrl serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 9 5.36 g/dl 0.09 0.28 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36261 401
LE/BluGill serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 9 6.39 g/dl 0.05 0.15 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36266 401
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 5 55.2 % 11.56 25.85 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36283 401
SS-Chr 1BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 173.06 breaths/min 10.05 31.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18336 381
WKY/NCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 54.84 mmHg 1.5 4.99 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17005 381
LEW/Crl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 13 55.32 mmHg 1.78 6.41 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17007 381
LE/BluGill partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 55.51 mmHg 2.17 6.15 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17011 381
WKY/NCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 11 56.6 mmHg 1.1 3.65 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17013 381
F344/DuCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 58.21 mmHg 1.3 3.18 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17014 381
Hsd:SD percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 %change=VE during7-9 min hypoxia/control during standard conditions 138.6 % 6.48 25.11 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17019 381
SS-Chr 14BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 7.48 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17024 381
FHH-Chr 12BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 7.49 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17032 381
FHH-Chr 8BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 7.49 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17048 381
FHH-Chr 8BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.5 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17059 381
FHH-Chr 15BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 145.72 breaths/min 7.78 23.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18305 381
GH/OmrMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 132.88 breaths/min 4.89 12.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18310 381
SS-Chr 7BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 117.47 breaths/min 7.76 24.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18316 381
SS-Chr YBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 19 124.91 breaths/min 4.36 19.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18332 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 11 6.36 g/dl 0.08 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36986 401
SS-Chr 12BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 5.55 g/dl 0.03 0.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36987 401
FHH-Chr 16BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 9 5.36 g/dl 0.16 0.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37005 401
FHH/EurMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 18 5.37 g/dl 0.08 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37014 401
SS-Chr 3BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 7 5.56 g/dl 0.13 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37018 401
SS-Chr 16BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 13 6.13 g/dl 0.07 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37020 401
FHH-Chr 13BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.53 g/dl 0.04 0.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37022 401
SS-Chr 11BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 17 5.89 g/dl 0.13 0.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37024 401
FHH/EurMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 50 5.36 g/dl 0.07 0.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37025 401
FHH-Chr 3BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 4.89 g/dl 0.13 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37026 401
SS-Chr 11BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 15 6.05 g/dl 0.13 0.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37027 401
SS-Chr 1BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 6 5.77 g/dl 0.05 0.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37032 401
FHH-Chr 9BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 7 4.83 g/dl 0.19 0.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37043 401
FHH/EurMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 18.9 pg 0.08 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 37072 401
FHH-Chr 2BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 79.25 mg/dl 3.54 10.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37089 401
SHR/NCrl serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 20 55.15 mg/dl 1.39 6.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37091 401
SHR/NCrl serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 17 77.35 mg/dl 1.49 6.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37094 401
SS-Chr 14BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 20 73.25 mg/dl 2.17 9.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37133 401
SS-Chr 6BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 84.63 mg/dl 4.0 11.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37135 401
SS-Chr 11BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 15 78.73 mg/dl 2.57 9.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37162 401
SS-Chr YBN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 20 88.25 mg/dl 1.93 8.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37163 401
FHH-Chr 11BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 59.0 mg/dl 2.49 7.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37171 401
FHH-Chr 7BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 79.5 mg/dl 1.78 5.64 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37179 401
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 121.87 breaths/min 5.75 17.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15370 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 114.38 breaths/min 4.73 14.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15380 381
SS-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 123.55 breaths/min 14.73 41.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14819 381
SS-Chr 9BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 111.09 breaths/min 6.06 19.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14829 381
FHH-Chr 17BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 110.4 breaths/min 4.15 13.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14841 381
FHH-Chr 17BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 120.14 breaths/min 7.52 22.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14843 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 23 96.03 breaths/min 3.91 18.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14873 381
FHH-Chr 9BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 140.36 breaths/min 10.32 30.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14876 381
FHH-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 125.9 breaths/min 8.59 24.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14802 381
FHH-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 121.71 breaths/min 9.21 30.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14804 381
FHH-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 156.15 breaths/min 9.77 30.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14781 381
FHH-Chr 6BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 141.77 breaths/min 9.3 30.85 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14782 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.36 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13651 381
FHH/EurMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 -0.34 degrees C 0.14 0.49 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14135 381
FHH-Chr 6BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 2 112.34 mmHg 53.92 76.25 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14305 381
SS-Chr 6BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 11 121.0 mmHg 3.86 12.81 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14313 381
SS-Chr 17BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 4 132.57 mmHg 5.02 10.03 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14321 381
SS-Chr 7BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 9 106.22 mmHg 6.38 19.13 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14326 381
FHH-Chr 8BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 116.74 mmHg 5.82 16.46 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14330 381
FHH-Chr 20BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 116.3 mmHg 4.26 11.27 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14347 381
SS-Chr YBN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 18 121.57 mmHg 3.51 14.91 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14353 381
FHH-Chr 1BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 15 121.71 mmHg 4.05 15.7 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14358 381
SS-Chr 4BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 131.58 mmHg 5.21 13.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14360 381
SS-Chr 18BN/Mcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during7-9 min hypoxia/control during standard conditions 123.74 % 7.62 22.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17912 381
SS/JrHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypoxia/control during standard conditions 148.65 % 12.89 40.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17922 381
SHR/NCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during7-9 min hypoxia/control during standard conditions 136.37 % 4.67 14.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17923 381
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 101.13 breaths/min 4.32 16.73 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17933 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 -50.36 mmHg 4.55 13.65 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17936 381
SS-Chr 16BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 -48.75 mmHg 2.21 6.26 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17937 381
SHR/NCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 4 -50.94 mmHg 3.02 6.05 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17945 381
F344/DuCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 123.56 breaths/min 6.1 25.9 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17564 381
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 39.15 ml/min 3.97 10.51 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18071 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 40.78 ml/min 3.23 9.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18074 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 53.23 ml/min 4.41 13.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18077 381
Hsd:SD blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 1 7.51 null automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18090 381
F344/DuCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.55 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18093 381
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 6 409.01 beats/min 5.21 12.75 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18104 381
F344/DuCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 -51.21 mmHg 4.0 9.8 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20694 381
SS/JrHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 10 53.39 mmHg 0.97 3.05 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19549 381
SHR/NCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 5 54.23 mmHg 1.9 4.25 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19559 381
SS/JrHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 -0.42 degrees C 0.2 0.68 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19573 381
SS-Chr 17BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 3 -2.83 mmHg 0.88 1.52 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19620 381
SS-Chr 17BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 2 -6.05 mmHg 1.75 2.47 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19624 381
FHH-Chr 16BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 -8.59 mmHg 1.17 3.32 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19631 381
SS-Chr 15BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 2 -1.2 mmHg 3.8 5.37 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19639 381
Crl:CD(SD) absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 -51.54 mmHg 2.2 5.82 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20690 381
SHR/NCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 7.53 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17608 381
BN/NHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 7.51 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17612 381
SS/JrHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.49 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17614 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 112.83 breaths/min 4.01 12.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17690 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 3 -6.23 mmHg 1.02 1.77 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17714 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 -7.9 mmHg 1.32 3.74 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17716 381
FHH/EurMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 37.25 degrees C 0.14 0.47 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17719 381
SS-Chr 13BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 -7.11 mmHg 1.15 3.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19647 381
FHH-Chr 20BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 -6.63 mmHg 1.0 2.63 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19649 381
SS-Chr 13BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 -6.64 mmHg 0.69 1.94 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19654 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 -6.11 mmHg 0.67 1.78 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19666 381
SS-Chr 19BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 1 -3.9 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19671 381
SS-Chr 12BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 3 -8.65 mmHg 1.18 2.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19675 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 12 -7.85 mmHg 1.78 6.16 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19676 381
SS-Chr XBN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 -5.68 mmHg 1.09 2.67 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19678 381
SS-Chr 20BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 6.14 g/dl 0.22 0.61 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37406 401
F344/DuCrl serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 17 107.76 U/l 7.3 30.1 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37425 401
LEW/Crl serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 74.6 U/l 4.07 12.87 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37428 401
WKY/NCrl serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 9 86.11 U/l 6.2 18.59 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37429 401
F344/DuCrl serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 15 87.13 U/l 4.48 17.34 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37430 401
SS-Chr 13BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 11 9.87 mg/dl 0.1 0.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36636 401
SS-Chr 18BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.18 mg/dl 0.24 0.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36638 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 9 9.22 mg/dl 0.11 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36643 401
GH/OmrMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 15 9.09 mg/dl 0.14 0.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36668 401
SS-Chr 3BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 7 9.1 mg/dl 0.1 0.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36680 401
SS-Chr XBN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 11 8.89 mg/dl 0.1 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36693 401
SS-Chr 4BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 29 9.51 mg/dl 0.08 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36695 401
SS/JrHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 9 8.86 mg/dl 0.08 0.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36696 401
FHH-Chr 7BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.24 mg/dl 0.06 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36701 401
FHH-Chr 7BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.26 mg/dl 0.11 0.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36706 401
SS-Chr 16BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 6 81.0 mg/dl 1.53 3.74 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36709 401
Hsd:SD mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 4 65.2 fl 0.92 1.83 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36714 401
F344/DuCrl serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 18 9.44 mg/dl 0.41 1.74 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36718 401
SS/JrHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 9 8.96 mg/dl 0.13 0.4 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36728 401
SS/JrHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 9 18.33 mmol/l 0.44 1.32 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36586 401
SS-Chr 20BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 16.75 mmol/l 1.08 3.06 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36588 401
SS-Chr 20BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 141.13 mmol/l 0.64 1.81 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36591 401
SS/JrHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 142.1 mmol/l 1.31 4.15 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36596 401
FHH-Chr 12BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 12 9.75 mg/dl 0.09 0.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36609 401
FHH-Chr 6BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.44 mg/dl 0.1 0.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36612 401
FHH-Chr 6BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.32 mg/dl 0.1 0.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36613 401
SS-Chr 5BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 7 9.54 mg/dl 0.08 0.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36622 401
FHH-Chr 14BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 37.25 ml/min 2.39 7.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18704 381
SS-Chr 7BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 37.12 ml/min 2.76 8.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18713 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 41.82 ml/min 3.95 15.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18715 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 396.45 beats/min 10.38 31.13 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17477 381
SS-Chr 14BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 436.17 beats/min 14.55 38.49 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17479 381
SS-Chr 10BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 9 393.11 beats/min 14.21 42.62 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17488 381
GH/OmrMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 4 447.79 beats/min 11.25 22.51 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17492 381
SS-Chr 17BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 4 356.59 beats/min 14.44 28.88 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17494 381
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 4 403.95 beats/min 35.32 70.63 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17496 381
SS-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 418.72 beats/min 12.0 36.0 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17512 381
SS-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 6 436.02 beats/min 34.89 85.45 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17527 381
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 13 399.04 beats/min 15.76 56.81 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17528 381
SS-Chr XBN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 6 372.01 beats/min 20.08 49.18 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17530 381
FHH-Chr 1BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 15 425.56 beats/min 14.49 56.12 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17531 381
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 13 226.69 beats/min 13.62 49.11 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17547 381
FHH-Chr 1BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 467.14 beats/min 24.71 65.38 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17552 381
GH/OmrMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 -46.56 mmHg 3.72 9.84 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18642 381
FHH-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 33.51 ml/min 1.39 4.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18653 381
FHH-Chr 10BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 33.69 ml/min 2.47 7.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18661 381
FHH-Chr 20BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 38.76 ml/min 1.82 5.47 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18668 381
FHH-Chr 5BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 46.87 ml/min 3.83 12.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18692 381
LEW/Crl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 20 %change=VE during 2-3 min hypoxia/control during standard conditions 138.23 % 5.11 22.86 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19306 381
WKY/NCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 20 %change=VE during 2-3 min hypoxia/control during standard conditions 140.34 % 6.19 27.68 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19307 381
SS-Chr 16BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 4 -8.06 mmHg 1.92 3.85 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19329 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 3 -7.0 mmHg 3.86 6.68 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19332 381
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 54.3 ml/min 3.56 13.81 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19434 381
FHH-Chr 12BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 -46.57 mmHg 2.47 8.2 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19447 381
GH/OmrMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 3 -47.45 mmHg 7.04 12.19 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19452 381
WKY/NCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 15 -0.54 degrees C 0.21 0.82 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19153 381
F344/DuCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 15 -0.41 degrees C 0.09 0.37 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19157 381
Hsd:SD heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 3 19.87 % 11.92 20.64 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49033 461
Hsd:SD heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 3 9.47 % 2.98 5.16 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49037 461
SS-Chr 10BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 126.56 breaths/min 9.64 31.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18294 381
SS-Chr 6BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 17 106.54 breaths/min 5.7 23.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18299 381
SS-Chr 9BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 105.17 breaths/min 3.08 9.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18300 381
FHH-Chr 8BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 43.87 ml/min 3.54 10.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20213 381
FHH-Chr 20BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 37.17 ml/min 1.82 5.47 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20214 381
SS-Chr 20BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 51.51 ml/min 2.54 9.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20219 381
SS-Chr 19BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 46.38 ml/min 6.24 17.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20228 381
SS-Chr 14BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 37.35 ml/min 1.47 5.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20245 381
SS-Chr 7BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 39.48 ml/min 3.93 11.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20254 381
FHH-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 25.72 ml/min 1.84 5.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20273 381
SS-Chr YBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 49.58 ml/min 1.8 7.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20275 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 46.98 ml/min 5.06 17.53 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20281 381
FHH-Chr 7BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 32.87 ml/min 4.5 14.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20286 381
Hsd:SD body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 19 37.05 degrees C 0.21 0.89 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20292 381
FHH-Chr 12BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 19 -0.29 degrees C 0.12 0.54 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20294 381
FHH-Chr 2BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 0.13 degrees C 0.12 0.37 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20301 381
SHR/NCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 20 -0.16 degrees C 0.21 0.92 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20303 381
SHR/NCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 18 -0.93 degrees C 0.18 0.76 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20306 381
SS-Chr 5BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 0.58 degrees C 0.18 0.55 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20307 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 3 29.33 mmHg 1.22 2.11 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18170 381
WKY/NCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 155.33 breaths/min 4.75 19.01 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18205 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 128.13 breaths/min 4.86 18.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18251 381
FHH-Chr 10BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 138.18 breaths/min 9.11 28.81 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18258 381
SS-Chr 20BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 14 135.8 breaths/min 4.6 17.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18276 381
SS-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 97.23 breaths/min 3.3 11.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18288 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 14 130.36 breaths/min 6.1 22.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18289 381
FHH-Chr 1BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 16 122.51 breaths/min 6.35 25.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18291 381
FHH-Chr 15BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 136.23 breaths/min 7.16 22.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18293 381
LEW/Crl heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 6.52 g/kg 0.16 0.5 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49149 461
FHH-Chr XBN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.14 degrees C 0.16 0.49 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20309 381
FHH-Chr 20BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 -0.73 degrees C 0.24 0.73 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20318 381
SS-Chr 13BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 -0.67 degrees C 0.32 0.96 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20321 381
FHH-Chr 4BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 0.08 degrees C 0.21 0.72 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20327 381
FHH-Chr 15BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 0.43 degrees C 0.21 0.67 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20337 381
SS-Chr 10BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 0.08 degrees C 0.15 0.5 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20338 381
SS-Chr 6BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 17 -0.18 degrees C 0.16 0.65 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20343 381
FHH-Chr 14BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 0.04 degrees C 0.12 0.37 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20351 381
FHH-Chr 16BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 -0.14 degrees C 0.31 0.93 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20361 381
FHH-Chr 19BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 14 -0.09 degrees C 0.22 0.83 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20363 381
SS/JrHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 76 -0.22 degrees C 0.09 0.77 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20377 381
SS-Chr XBN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 0.48 degrees C 0.23 0.79 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20379 381
SS-Chr 4BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 15 0.07 degrees C 0.2 0.78 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20385 381
BN/NHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 23 -1.64 degrees C 0.25 1.18 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20388 381
SS-Chr XBN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 14 0.59 degrees C 0.19 0.71 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20390 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 56.77 mmHg 1.99 5.98 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20454 381
FHH-Chr 6BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 1 60.1 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20455 381
SS-Chr 6BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 55.89 mmHg 1.22 4.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20458 381
FHH-Chr 19BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 9 54.34 mmHg 2.56 7.67 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20477 381
SS-Chr 16BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 10 54.07 mmHg 0.7 2.22 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20479 381
FHH-Chr 20BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 4 55.0 mmHg 2.89 5.77 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20488 381
SS-Chr 20BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 10 51.99 mmHg 1.13 3.57 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20493 381
SS-Chr 11BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 62.62 mmHg 2.21 5.42 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20495 381
SS-Chr 4BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 7 57.74 mmHg 1.92 5.07 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20505 381
FHH-Chr 4BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 2 54.5 mmHg 2.2 3.11 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20507 381
SS-Chr 19BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 49.67 mmHg 3.42 5.92 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20510 381
SS-Chr 19BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 1 60.6 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20514 381
SS-Chr XBN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 60.16 mmHg 3.58 8.77 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20521 381
FHH-Chr 7BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 2 50.9 mmHg 1.95 2.76 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20522 381
SS/JrHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 10 0.07 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20538 381
FHH/EurMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 0.07 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20539 381
SS-Chr 15BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 4 -38.5 mmHg 3.55 7.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19468 381
FHH-Chr 18BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 -43.07 mmHg 2.52 7.13 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19479 381
SS-Chr 20BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 10 -43.04 mmHg 2.53 7.99 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19481 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 9 -41.66 mmHg 2.98 8.93 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19488 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 49 -47.43 mmHg 1.07 7.51 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19489 381
SS-Chr XBN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 3 -45.52 mmHg 4.53 7.84 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19490 381
SS-Chr 12BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 -51.35 mmHg 5.64 9.76 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19499 381
BN/NHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 12 -43.74 mmHg 2.47 8.55 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19507 381
BN/NHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 -40.3 mmHg 1.83 5.18 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19508 381
FHH-Chr 9BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 26.8 mmHg 2.73 8.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50077 461
F344/DuCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 135.0 g 1.8 5.7 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50082 461
SS/JrHsdMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 4 1012.83 s 61.58 123.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50098 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 14 1097.74 s 40.71 152.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50213 461
FHH-Chr 12BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 12 1139.92 s 62.15 215.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50218 461
SS-Chr 5BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 1037.38 s 26.13 73.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50225 461
FHH-Chr 10BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 1145.33 s 43.54 130.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50226 461
FHH-Chr 8BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 1172.5 s 64.13 181.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50228 461
SS-Chr 15BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 1007.22 s 72.86 218.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50231 461
SS-Chr 7BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 5.58 % 3.58 11.34 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49747 461
SS-Chr 16BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 22 27.52 % 2.42 11.35 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49755 461
SS/JrHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 16 26.73 % 6.45 25.78 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49769 461
SS-Chr XBN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 11 15.21 % 3.1 10.28 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49777 461
FHH-Chr 7BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 6.3 % 1.67 5.3 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49779 461
SS/JrHsdMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 11 51.64 mmHg 4.09 13.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 49792 461
F344/DuCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 144.34 mmHg 5.3 15.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49810 461
Hsd:SD percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 66.38 % 10.23 28.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49812 461
FHH-Chr 8BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 90.69 mmHg 14.81 41.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49889 461
FHH-Chr 20BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 105.6 mmHg 2.82 8.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49897 461
SS-Chr 20BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 22 99.88 mmHg 3.94 18.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49899 461
FHH-Chr YBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 80.04 mmHg 7.8 24.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49901 461
GH/OmrMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 6 9.38 % 2.95 7.23 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 49630 461
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 116.33 mmHg 7.03 21.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49650 461
WKY/NCrl percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 63.01 % 8.38 25.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49651 461
F344/DuCrl percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 64.53 % 4.18 12.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49654 461
LEW/Crl percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 57.9 % 7.28 23.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49658 461
GH/OmrMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.32 IU/g 0.04 0.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 49682 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 13 10.36 % 2.48 8.95 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49684 461
SS-Chr 18BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 14 18.8 % 5.2 19.44 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49715 461
SS-Chr 6BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 10.21 % 3.02 9.54 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49736 461
SS-Chr 7BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 11 6.32 % 2.06 6.83 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49743 461
FHH-Chr 15BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 71.28 mmHg 10.11 24.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49916 461
SS-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 89.57 mmHg 7.05 27.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49920 461
FHH-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 87.95 mmHg 6.03 19.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49960 461
SS-Chr 4BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 18 95.32 mmHg 6.08 25.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49962 461
LE/BluGill heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 255.49 beats/min 10.11 31.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49976 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 3 306.3 beats/min 21.43 37.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49975 461
FHH-Chr 8BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 34.0 mmHg 5.6 15.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49998 461
SS-Chr 13BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 21 46.52 mmHg 2.69 12.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50004 461
SS-Chr 19BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 36.67 mmHg 2.13 6.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50017 461
SS-Chr 19BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 34.8 mmHg 2.41 7.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50019 461
FHH-Chr 1BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 43.3 mmHg 2.9 9.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50023 461
SS-Chr 2BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 58.0 mmHg 6.97 22.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50024 461
FHH-Chr 15BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 24.5 mmHg 2.77 7.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50025 461
SS-Chr 9BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 17 52.29 mmHg 3.48 14.34 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50031 461
FHH-Chr 5BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 31.67 mmHg 2.02 6.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50032 461
SS-Chr 10BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 45.1 mmHg 3.49 11.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50037 461
GH/OmrMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 42.33 mmHg 5.6 16.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50041 461
FHH-Chr 17BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 19 39.26 mmHg 2.44 10.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50045 461
FHH/EurMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 14 34.29 mmHg 2.76 10.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50048 461
SS-Chr 16BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 21 53.0 mmHg 3.32 15.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50054 461
SS/JrHsdMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 97 50.08 mmHg 1.5 14.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50063 461
FHH-Chr 5BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 136.4 g 11.4 36.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49504 461
FHH-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 12 169.2 g 6.0 20.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49508 461
FHH-Chr 15BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 9 91.1 g 6.5 19.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49510 461
FHH-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 9 114.8 g 6.4 19.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49512 461
SS-Chr 5BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 158.7 g 4.5 14.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49520 461
FHH-Chr 19BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 144.0 g 6.2 19.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49531 461
SS-Chr 16BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 20 197.6 g 6.8 30.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49539 461
SS-Chr 13BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 22 155.1 g 3.9 18.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49543 461
SS-Chr XBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 12 112.1 g 7.2 25.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49560 461
SS-Chr 1BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 11 150.0 g 6.7 22.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49564 461
SS/JrHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 133.5 g 6.1 19.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49566 461
FHH-Chr 4BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 108.7 g 6.7 21.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49568 461
SS-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 131.0 g 2.0 6.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49577 461
FHH-Chr 7BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 156.3 g 4.5 14.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49583 461
FHH-Chr 1BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1125.69 s 42.89 135.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50242 461
FHH-Chr 4BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1206.1 s 32.33 102.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50245 461
SS-Chr 19BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 1103.33 s 36.37 109.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50247 461
SS-Chr 2BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1105.2 s 28.59 90.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50254 461
FHH-Chr 5BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 1109.67 s 31.8 95.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50262 461
FHH-Chr 16BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 19 1161.58 s 23.25 101.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50270 461
FHH-Chr 17BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 17 1179.29 s 30.51 125.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50273 461
SS-Chr 4BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 20 1074.65 s 27.57 123.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50297 461
FHH-Chr 7BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1184.9 s 46.01 145.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50308 461
Hsd:SD percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 3 post-ischemic value/pre-ischemic value x 100% 86.24 % 8.12 14.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49265 461
LE/BluGill percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 79.93 % 6.91 21.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49266 461
FHH-Chr 20BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 977.4 s 34.87 110.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49305 461
SS-Chr 10BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 810.0 s 47.92 143.75 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49328 461
FHH-Chr 15BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 991.13 s 82.23 232.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49338 461
FHH-Chr 3BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 5 964.8 s 44.0 98.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49352 461
SS-Chr 11BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 24 862.88 s 30.1 147.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49363 461
SS-Chr 4BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 19 878.05 s 32.21 140.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49373 461
SS-Chr XBN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 11 942.82 s 42.2 139.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49378 461
Hsd:SD serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 3 1.83 g/dl 0.18 0.31 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38975 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 14 51.74 % 2.06 7.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38977 401
SS-Chr 5BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 7 55.91 % 0.38 0.99 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38989 401
FHH-Chr 20BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 51.14 % 0.58 1.85 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39000 401
SS-Chr 20BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 33 53.99 % 0.92 5.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39002 401
SS-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 55.28 % 0.71 2.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39005 401
SS-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 55.93 % 0.68 1.93 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39008 401
SS-Chr 6BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 57.04 % 0.6 1.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39024 401
FHH-Chr 14BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 53.45 % 1.15 3.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39032 401
SS-Chr 17BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 51.73 % 1.03 2.91 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39033 401
SS-Chr 17BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.95 g/dl 0.05 0.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42280 401
SS-Chr 16BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 16 3.94 g/dl 0.03 0.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42288 401
FHH/EurMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 50 3.66 g/dl 0.05 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42296 401
FHH-Chr 3BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.18 g/dl 0.12 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42297 401
SS-Chr 4BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 29 3.69 g/dl 0.03 0.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42304 401
BN/NHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 20 3.65 g/dl 0.05 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42311 401
SS/JrHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 9 54.67 U/l 4.78 14.34 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42341 401
Crl:CD(SD) serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 9 246.67 U/l 20.24 60.73 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42348 401
LE/BluGill serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 9 286.67 U/l 14.7 44.1 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42351 401
Crl:CD(SD) blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 9 1.07 x 1000 cells/ul 0.16 0.47 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42368 401
Crl:CD(SD) blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 9 1.32 x 1000 cells/ul 0.21 0.63 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42370 401
SS-Chr 16BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 7 3.8 g/dl 0.08 0.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42396 401
FHH-Chr 12BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 12 15.17 mmol/l 0.89 3.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42047 401
FHH-Chr 6BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 20.1 mmol/l 0.74 2.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42051 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 18.2 mmol/l 0.94 2.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42052 401
FHH-Chr 12BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 11 13.64 mmol/l 0.51 1.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42053 401
FHH-Chr 2BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 16.25 mmol/l 0.56 1.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42054 401
FHH-Chr XBN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 19.13 mmol/l 0.97 2.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42058 401
SS-Chr 5BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 7 20.71 mmol/l 0.42 1.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42060 401
FHH-Chr 8BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 20.5 mmol/l 0.91 2.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42063 401
FHH-Chr 18BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 21.8 mmol/l 1.31 4.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42072 401
SS-Chr 13BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 11 14.0 mmol/l 0.99 3.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42074 401
SS-Chr 18BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 9 21.0 mmol/l 0.83 2.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42079 401
SS-Chr 12BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 22.5 mmol/l 0.63 1.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42083 401
FHH-Chr 1BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 9 14.89 mmol/l 0.7 2.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42088 401
SS-Chr 2BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 13 14.92 mmol/l 0.4 1.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42089 401
SS-Chr 10BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 21.8 mmol/l 0.42 1.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42091 401
SS-Chr 14BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 17 20.12 mmol/l 0.7 2.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42094 401
SS-Chr 14BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 20 19.6 mmol/l 0.68 3.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42098 401
SS-Chr 6BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 16.75 mmol/l 1.19 3.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42100 401
FHH-Chr 14BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 20.75 mmol/l 0.96 2.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42103 401
FHH-Chr 17BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 6 21.67 mmol/l 1.63 3.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42108 401
SS-Chr 17BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 50.0 % 0.87 2.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39038 401
FHH-Chr 13BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 54.41 % 0.5 1.59 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39051 401
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 47 55.55 % 0.52 3.59 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39054 401
FHH-Chr 11BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 51.41 % 1.33 4.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39065 401
SS-Chr XBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 54.99 % 0.61 1.91 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39071 401
FHH-Chr 7BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 55.68 % 0.65 2.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39073 401
LEW/Crl serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.75 mmol/l 0.19 0.59 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39093 401
Crl:CD(SD) serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 9 4.43 mmol/l 0.13 0.39 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39096 401
LE/BluGill serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 9 5.22 mmol/l 0.19 0.58 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39101 401
FHH-Chr 20BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 109.0 mmol/l 0.68 2.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39123 401
FHH-Chr YBN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 9 107.44 mmol/l 0.34 1.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39130 401
FHH-Chr 1BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 15 110.27 mmol/l 1.08 4.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39132 401
FHH-Chr 4BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 7 108.14 mmol/l 0.51 1.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39135 401
SS-Chr 12BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 107.5 mmol/l 0.6 1.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39142 401
FHH-Chr 1BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 9 111.56 mmol/l 0.71 2.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39143 401
SS-Chr 10BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 106.4 mmol/l 0.27 0.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39146 401
SS-Chr 19BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.58 g/dl 0.11 0.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42255 401
FHH-Chr 15BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.33 g/dl 0.07 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42261 401
FHH-Chr 5BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.79 g/dl 0.07 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42263 401
FHH-Chr 12BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 11 55.58 fl 0.18 0.61 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38736 401
SS-Chr 5BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 63.58 fl 0.4 1.14 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38740 401
FHH-Chr XBN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 7 58.73 fl 0.49 1.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38745 401
FHH-Chr 8BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 58.33 fl 0.16 0.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38746 401
GH/OmrMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 18 16.0 mmol/l 0.56 2.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42111 401
FHH-Chr 13BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 20.5 mmol/l 0.54 1.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42122 401
FHH/EurMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 51 18.31 mmol/l 0.54 3.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42125 401
SS-Chr 20BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 7 73.43 U/l 5.82 15.4 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42169 401
SS/JrHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 4 6.1 g/dl 0.07 0.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42190 401
FHH-Chr 6BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.86 g/dl 0.04 0.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42221 401
SS-Chr 20BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 27 4.13 g/dl 0.03 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42235 401
FHH-Chr 18BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.73 g/dl 0.05 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42243 401
FHH-Chr YBN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 9 3.78 g/dl 0.05 0.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42246 401
FHH-Chr 1BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 15 3.89 g/dl 0.05 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42248 401
FHH-Chr 4BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.46 g/dl 0.08 0.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42249 401
FHH-Chr 4BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 57.64 fl 0.24 0.69 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38761 401
SS-Chr 19BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 62.1 fl 0.4 1.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38767 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 11 59.42 fl 0.5 1.66 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38769 401
SS-Chr 2BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 15 63.15 fl 0.52 2.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38772 401
FHH-Chr 15BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 58.04 fl 0.53 1.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38773 401
FHH-Chr 14BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 58.31 fl 0.44 1.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38776 401
SS-Chr 6BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 7 59.89 fl 2.44 6.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38783 401
FHH-Chr 16BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 9 60.26 fl 0.39 1.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38788 401
GH/OmrMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 12 60.69 fl 1.07 3.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38789 401
SS-Chr 17BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 62.23 fl 0.83 2.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38792 401
SS-Chr 16BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 15 61.9 fl 0.2 0.77 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38800 401
FHH-Chr 9BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 6 56.43 fl 0.54 1.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38821 401
FHH-Chr 7BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 58.75 fl 0.66 2.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38827 401
SS-Chr 16BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 6 4.38 mmol/l 0.12 0.31 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 38830 401
FHH/EurMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 5.73 mmol/l 0.33 0.88 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 38832 401
SS/JrHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 6 4.78 mmol/l 0.31 0.75 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 38833 401
Hsd:SD blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 16 17.64 g/dl 0.3 1.19 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38876 401
GH/OmrMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 18 143.67 mmol/l 0.75 3.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39437 401
FHH-Chr 13BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 142.5 mmol/l 0.65 2.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39447 401
FHH-Chr 13BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 142.8 mmol/l 0.63 1.99 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39448 401
FHH-Chr 3BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 142.88 mmol/l 1.03 2.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39452 401
SS/JrHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 96 142.69 mmol/l 0.31 3.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39455 401
SS-Chr 4BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 29 143.0 mmol/l 0.35 1.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39459 401
SS-Chr 4BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 29 141.79 mmol/l 0.31 1.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39463 401
FHH-Chr 9BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 7 141.57 mmol/l 0.48 1.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39464 401
FHH-Chr 9BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 7 143.71 mmol/l 0.64 1.7 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39469 401
FHH-Chr 7BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 141.8 mmol/l 0.66 2.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39470 401
WKY/NCrl total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 3.91 x 1000 cells/ul 0.79 2.25 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39489 401
SS-Chr 20BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.22 x 1000 cells/ul 0.07 0.2 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39536 401
SS-Chr 20BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.4 mg/dl 0.04 0.11 automated plasma creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39539 401
SS-Chr 20BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.28 mg/dl 0.05 0.13 automated plasma creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39542 401
LE/BluGill mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 31.91 g/dl 0.13 0.4 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42734 401
F344/DuCrl mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 32.27 g/dl 0.12 0.4 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42737 401
LE/BluGill mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 32.19 g/dl 0.09 0.28 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42738 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 13 85.0 U/l 4.14 14.92 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42756 401
FHH-Chr 12BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 11 91.82 U/l 3.43 11.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42761 401
SS-Chr 5BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 68.5 U/l 3.16 8.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42765 401
FHH-Chr 8BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 93.1 U/l 5.85 18.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42775 401
FHH-Chr 20BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 90.8 U/l 3.09 9.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42776 401
FHH-Chr 20BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 85.2 U/l 2.66 8.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42779 401
FHH-Chr YBN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 9 115.0 U/l 8.13 24.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42783 401
FHH-Chr 4BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 7 79.43 U/l 5.12 13.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42788 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 9 90.67 U/l 9.05 27.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42789 401
SS-Chr 19BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 80.8 U/l 11.8 37.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42790 401
SS-Chr 2BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 85.0 U/l 8.57 27.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42793 401
FHH-Chr 2BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 140.63 mmol/l 0.92 2.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39375 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 143.8 mmol/l 1.02 3.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39378 401
FHH-Chr 2BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 141.75 mmol/l 0.84 2.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39380 401
FHH-Chr 8BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 140.5 mmol/l 0.52 1.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39389 401
FHH-Chr 8BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 140.5 mmol/l 0.67 2.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39393 401
FHH-Chr 18BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 143.3 mmol/l 0.63 2.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39396 401
FHH-Chr 20BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 141.5 mmol/l 0.79 2.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39397 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 9 145.56 mmol/l 0.65 1.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39407 401
SS-Chr 19BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 142.7 mmol/l 0.54 1.7 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39408 401
SS-Chr 2BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 15 146.27 mmol/l 0.48 1.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39415 401
FHH-Chr 14BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 145.63 mmol/l 0.46 1.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39419 401
SS-Chr 6BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 9 144.56 mmol/l 0.9 2.7 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39421 401
FHH-Chr 5BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 141.88 mmol/l 0.52 1.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39423 401
SS-Chr 7BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 11 142.45 mmol/l 0.61 2.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39433 401
SS-Chr 1BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 6 8.5 x 10E6 cells/ul 0.11 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39305 401
SS-Chr XBN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 11 8.71 x 10E6 cells/ul 0.1 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39306 401
FHH-Chr 11BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 9.55 x 10E6 cells/ul 0.24 0.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39310 401
SS-Chr XBN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 9.09 x 10E6 cells/ul 0.09 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39317 401
FHH/EurMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 7 222.57 mg/dl 15.07 39.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39321 401
SS-Chr 16BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 6 167.17 mg/dl 13.59 33.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39322 401
FHH/EurMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 7 186.71 mg/dl 29.64 78.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39324 401
WKY/NCrl serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 8.6 mg/dl 0.13 0.4 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42520 401
LE/BluGill serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 9 9.34 mg/dl 0.16 0.49 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42525 401
FHH-Chr 6BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 18.94 pg 0.07 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42534 401
SHR/NCrl mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 15 16.76 pg 0.08 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42542 401
FHH-Chr 10BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.52 pg 0.14 0.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42544 401
FHH-Chr XBN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 18.81 pg 0.09 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42545 401
SS-Chr 12BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 64.0 U/l 4.23 11.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42795 401
SS-Chr 14BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 16 70.69 U/l 4.22 16.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42802 401
FHH/EurMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 18 96.89 U/l 4.74 20.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42822 401
FHH-Chr 13BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 94.9 U/l 5.39 17.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42830 401
SS-Chr 1BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 6 113.83 U/l 8.96 21.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42838 401
SS-Chr 4BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 28 72.71 U/l 2.72 14.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42841 401
SS-Chr XBN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 97.8 U/l 5.72 18.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42850 401
FHH-Chr 7BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 103.4 U/l 7.57 23.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42852 401
FHH-Chr 18BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 18.32 pg 0.13 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42553 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 19.61 pg 0.18 0.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42564 401
SS-Chr 12BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 19.89 pg 0.15 0.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42566 401
SS-Chr 2BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 20.1 pg 0.15 0.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42572 401
SS-Chr 14BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 17 19.4 pg 0.11 0.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42577 401
SS-Chr 7BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 21.02 pg 0.15 0.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42590 401
FHH-Chr 17BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 18.73 pg 0.09 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42593 401
FHH-Chr 16BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 18.87 pg 0.11 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42596 401
FHH-Chr 19BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 18.48 pg 0.15 0.46 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42598 401
SS-Chr 16BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 15 20.06 pg 0.18 0.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42600 401
SS-Chr 3BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 18.99 pg 0.26 0.69 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42601 401
FHH-Chr 19BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 19.0 pg 0.1 0.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42602 401
FHH/EurMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 49 18.29 pg 0.1 0.69 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42608 401
FHH-Chr 7BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 18.73 pg 0.07 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42622 401
SS-Chr 7BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 11 113.73 mmol/l 0.63 2.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39162 401
FHH-Chr 16BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 9 108.44 mmol/l 0.24 0.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39168 401
FHH-Chr 13BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 109.6 mmol/l 0.64 2.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39176 401
SS-Chr 11BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 15 107.67 mmol/l 0.44 1.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39182 401
SS-Chr 1BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 6 109.5 mmol/l 1.02 2.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39187 401
FHH-Chr 7BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 110.0 mmol/l 0.58 1.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39199 401
F344/DuCrl serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 18 2.15 g/dl 0.05 0.22 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39215 401
LE/BluGill serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 9 2.11 g/dl 0.04 0.12 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39217 401
F344/DuCrl serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 17 2.19 g/dl 0.05 0.22 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39220 401
LE/BluGill serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 2.31 g/dl 0.06 0.18 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39221 401
FHH-Chr 20BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 9.96 x 10E6 cells/ul 0.81 2.55 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39243 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 11 10.0 x 10E6 cells/ul 0.12 0.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39261 401
SS-Chr 2BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 15 9.31 x 10E6 cells/ul 0.15 0.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39264 401
SS-Chr 9BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 15 9.15 x 10E6 cells/ul 0.09 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39274 401
SS-Chr 17BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 8.03 x 10E6 cells/ul 0.2 0.55 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39284 401
SS-Chr 7BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 12 8.54 x 10E6 cells/ul 0.11 0.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39287 401
FHH-Chr 19BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 8.55 x 10E6 cells/ul 0.15 0.46 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39294 401
SS-Chr 3BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 7 8.12 x 10E6 cells/ul 0.28 0.73 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39298 401
WKY/NCruk mean pulmonary arterial blood pressure controlled air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 pulmonary arterial blood pressure trait male 105 days 28 median 38.0 mmHg vascular indwelling catheter method pulmonary artery 0 0 66126 102
F344/NHsd hematocrit controlled air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 erythrocyte quantity male 105 days 23 median 70.0 % hematocrit analysis 0 0 66132 102
SS-Chr 6BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 110.0 mmol/l 0.91 2.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39155 401
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 143.92 % 5.23 22.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54312 381
SS-Chr 5BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 149.73 % 14.83 46.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54319 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 140.58 % 6.55 25.37 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54323 381
GH/OmrMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 6 119.17 % 10.79 26.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54325 381
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 23 123.27 % 3.81 18.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54336 381
SS-Chr 19BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 130.92 % 15.94 45.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54348 381
SS-Chr 19BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 138.74 % 15.35 46.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54350 381
SS-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 110.54 % 6.74 19.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54352 381
FHH-Chr 1BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 16 127.3 % 7.08 28.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54353 381
SS-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 118.05 % 5.02 18.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54354 381
FHH-Chr 5BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 141.96 % 9.83 31.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54357 381
FHH-Chr 15BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 142.56 % 10.31 30.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54366 381
SS-Chr 10BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 152.72 % 10.11 31.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54367 381
FHH-Chr 14BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 137.23 % 9.0 28.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54368 381
SS-Chr 17BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 123.25 % 5.17 17.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54369 381
SS-Chr 7BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 141.87 % 8.28 24.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54371 381
FHH-Chr 16BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 127.24 % 5.72 17.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54376 381
SS-Chr 16BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 137.44 % 7.72 28.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54380 381
SS-Chr YBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 19 128.31 % 3.17 13.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54391 381
SS-Chr 1BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 112.38 % 10.48 33.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54393 381
SS-Chr 4BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 110.89 % 7.54 25.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54398 381
FHH-Chr 11BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 136.18 % 13.06 36.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54399 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 74 133.46 % 3.99 34.33 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54404 381
FHH-Chr XBN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 7 1.1 x 1000 cells/ul 0.23 0.61 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43224 401
SS-Chr 15BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 0.78 x 1000 cells/ul 0.1 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43227 401
FHH-Chr 4BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 0.95 x 1000 cells/ul 0.14 0.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43240 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.72 x 1000 cells/ul 0.3 0.86 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43243 401
FHH-Chr 5BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 1.15 x 1000 cells/ul 0.3 0.85 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43259 401
GH/OmrMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 12 0.69 x 1000 cells/ul 0.14 0.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43268 401
FHH/EurMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 49 0.88 x 1000 cells/ul 0.1 0.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43287 401
Crl:CD(SD) percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 137.41 % 8.77 29.09 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54519 381
WKY/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 20 125.38 % 4.3 19.23 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54523 381
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 163.4 % 14.9 33.32 stop flow air displacement plethysmography 0 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54525 381
SS-Chr 5BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 31.83 g/dl 0.15 0.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39772 401
FHH-Chr XBN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 32.01 g/dl 0.17 0.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39777 401
FHH-Chr 8BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 31.79 g/dl 0.09 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39778 401
FHH-Chr 18BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 31.84 g/dl 0.1 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39785 401
SS-Chr 18BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 32.47 g/dl 0.12 0.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39791 401
SS-Chr 2BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 31.85 g/dl 0.11 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39804 401
FHH-Chr 5BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 31.45 g/dl 0.42 1.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39807 401
FHH-Chr 14BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 31.96 g/dl 0.17 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39808 401
FHH-Chr 15BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 32.04 g/dl 0.17 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39816 401
SS-Chr 7BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 32.96 g/dl 0.11 0.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39822 401
GH/OmrMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 16 32.58 g/dl 0.12 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39826 401
FHH/EurMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 16 32.08 g/dl 0.08 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39829 401
SS/JrHsdMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 90 32.24 g/dl 0.07 0.68 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39844 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 14 0.27 mg/dl 0.02 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39562 401
FHH-Chr 6BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.37 mg/dl 0.03 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39564 401
FHH-Chr 6BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.36 mg/dl 0.03 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39565 401
SS-Chr 1BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 32.67 g/dl 0.17 0.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39847 401
FHH-Chr 7BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 31.98 g/dl 0.09 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39859 401
SS/JrHsdMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 7 2.19 g/dl 0.11 0.3 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Dyets 39968 401
FHH-Chr 15BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.4 x 1000 cells/ul 0.1 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39702 401
FHH-Chr 3BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.21 x 1000 cells/ul 0.05 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39728 401
SS-Chr 16BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 13 0.3 x 1000 cells/ul 0.04 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39732 401
FHH-Chr 13BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.1 x 1000 cells/ul 0.04 0.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39733 401
SS-Chr 4BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 29 0.23 x 1000 cells/ul 0.04 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39749 401
FHH-Chr 6BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 31.99 g/dl 0.09 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39765 401
SS-Chr 5BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.38 mg/dl 0.03 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39571 401
FHH-Chr YBN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 9 0.32 mg/dl 0.01 0.04 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39589 401
SS-Chr 18BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 9 0.29 mg/dl 0.02 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39593 401
FHH-Chr 15BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.3 mg/dl 0.03 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39615 401
FHH-Chr 17BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 6 0.3 mg/dl 0.03 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39622 401
FHH/EurMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 18 0.31 mg/dl 0.02 0.1 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39628 401
FHH-Chr 19BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.3 mg/dl 0.03 0.11 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39629 401
FHH-Chr 13BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.25 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39635 401
SS-Chr 1BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 6 0.35 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39646 401
FHH-Chr 2BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.3 x 1000 cells/ul 0.08 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39661 401
FHH-Chr 6BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.42 x 1000 cells/ul 0.06 0.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39662 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.34 x 1000 cells/ul 0.07 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39664 401
FHH-Chr 12BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 11 0.22 x 1000 cells/ul 0.04 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39665 401
FHH-Chr 10BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 7 0.38 x 1000 cells/ul 0.1 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39667 401
SHR/NCrl blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 18 0.37 x 1000 cells/ul 0.04 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39668 401
FHH-Chr 8BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.16 x 1000 cells/ul 0.05 0.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39675 401
SS-Chr 20BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 26 0.26 x 1000 cells/ul 0.05 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39676 401
Hsd:SD FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 21.73 ml/min/kg 1.16 3.08 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59027 526
SS-Chr 20BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 17.69 ml/min/kg 5.0 12.25 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59028 526
SS/JrHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 25.94 ml/min/kg 3.61 9.54 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59030 526
SS-Chr 16BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 0.16 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Dyets 59034 526
SHR/NCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 25 153.6 g 1.8 9.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59059 526
FHH-Chr 8BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 144.3 g 3.1 9.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59063 526
SS-Chr 19BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 189.3 g 6.0 18.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59084 526
SS-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 145.5 g 2.3 7.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59085 526
FHH-Chr 5BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 133.6 g 4.5 14.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59092 526
SS-Chr 14BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 20 233.5 g 6.1 27.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59098 526
FHH-Chr 15BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 13 104.2 g 3.9 14.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59101 526
SS-Chr 7BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 12 160.1 g 3.5 12.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59112 526
FHH/EurMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 20 165.3 g 2.4 10.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59114 526
FHH-Chr 13BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 187.0 g 6.3 19.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59122 526
SS-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 14 131.0 g 7.5 28.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59123 526
FHH/EurMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 64 185.3 g 5.2 41.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59125 526
SS-Chr 4BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 22 228.0 g 3.4 16.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59133 526
FHH-Chr 11BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 160.0 g 5.5 17.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59136 526
BN/NHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 32 189.6 g 2.5 14.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59140 526
SS-Chr 16BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 7 0.55 x 1000 cells/ul 0.1 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40386 401
FHH-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 6 2.2 mg/kg 0.44 1.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58979 526
SS-Chr XBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 1.71 mg/kg 0.31 0.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58986 526
FHH/EurMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 7 146.0 U/l 28.35 75.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 43412 401
FHH/EurMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 8 1.31 g/kg 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 58874 526
FHH-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 2.57 mg/kg 0.74 2.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58898 526
SHR/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 14 1.42 mg/kg 0.26 0.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58903 526
FHH-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 1.05 mg/kg 0.17 0.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58915 526
FHH-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 3.81 mg/kg 0.73 1.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58945 526
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 19 4.0 mg/kg 1.04 4.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58958 526
SS/JrHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.91 x 1000 cells/ul 0.23 0.73 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43296 401
FHH-Chr 7BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.47 x 1000 cells/ul 0.09 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43301 401
BN/NHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 13 0.95 x 1000 cells/ul 0.28 0.99 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43303 401
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 118.99 % 5.87 18.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54551 381
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 116.9 % 7.85 23.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54558 381
SS-Chr 16BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 158.84 % 12.52 33.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54564 381
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 150.45 % 6.35 20.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54565 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 151.92 % 8.03 27.8 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53540 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 114.4 % 4.57 13.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53546 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 112.41 % 9.21 27.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53554 381
GH/OmrMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 107.93 % 7.2 20.38 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53573 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 139.48 % 6.01 20.81 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53594 381
Crl:CD(SD) percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 128.24 % 4.58 16.5 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53602 381
LEW/Crl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 106.28 % 3.08 13.05 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53607 381
SS-Chr 16BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 151.66 % 16.32 43.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53733 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 136.94 % 11.45 34.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53735 381
SS-Chr 5BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.57 x 1000 cells/ul 0.08 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43219 401
SS-Chr 5BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 7 0.84 x 1000 cells/ul 0.1 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43222 401
SS-Chr 11BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 17 52.75 % 1.12 4.6 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59319 526
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 46 55.29 % 0.42 2.83 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59320 526
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 90 57.97 % 0.34 3.26 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59324 526
SS-Chr 1BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 12 54.38 % 0.76 2.63 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59327 526
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 56.07 % 0.44 1.38 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59329 526
FHH-Chr 11BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 51.41 % 1.33 4.22 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59331 526
SS-Chr XBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 54.99 % 0.61 1.91 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59337 526
LEW/Crl serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.29 mg/dl 0.04 0.12 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37547 401
LE/BluGill serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37550 401
Crl:CD(SD) plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 21.5 mmol/l 0.6 1.69 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37553 401
Crl:CD(SD) plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 9 23.0 mmol/l 0.76 2.29 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37555 401
SS-Chr 20BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 20.24 pg 0.15 0.42 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37561 401
Hsd:SD serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 18 8.86 mg/dl 0.16 0.68 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37575 401
FHH-Chr 2BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 7 10.9 mg/dl 0.35 0.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37581 401
SHR/NCrl serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 20 7.8 mg/dl 0.14 0.64 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37588 401
SS-Chr 20BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 27 8.96 mg/dl 0.21 1.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37596 401
FHH-Chr 20BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 8.2 mg/dl 0.2 0.64 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37603 401
SS-Chr 18BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 9 8.02 mg/dl 0.15 0.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37611 401
SS-Chr 2BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 15 8.82 mg/dl 0.14 0.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37621 401
FHH-Chr 14BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 9.19 mg/dl 0.38 1.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37635 401
SS-Chr 7BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 11 8.85 mg/dl 0.21 0.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37639 401
GH/OmrMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 18 9.24 mg/dl 0.2 0.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37643 401
SS-Chr 7BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 12 8.09 mg/dl 0.23 0.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37644 401
FHH/EurMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 17 7.85 mg/dl 0.36 1.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37646 401
FHH-Chr 19BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 8.98 mg/dl 0.35 1.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37647 401
SS-Chr 3BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 7 9.56 mg/dl 0.38 1.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37650 401
SS-Chr 16BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 14 8.69 mg/dl 0.18 0.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37652 401
FHH-Chr 13BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 7.93 mg/dl 0.13 0.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37654 401
FHH/EurMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 49 9.31 mg/dl 0.26 1.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37657 401
FHH-Chr 11BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 9 10.18 mg/dl 0.19 0.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37667 401
SS-Chr 4BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 29 8.13 mg/dl 0.12 0.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37669 401
BN/NHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 20 8.04 mg/dl 0.17 0.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37672 401
WKY/NCrl plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 9 0.32 mg/dl 0.01 0.04 automated plasma creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40804 401
GH/OmrMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 18 2.26 g/dl 0.04 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40599 401
FHH-Chr 19BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.43 g/dl 0.08 0.25 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40603 401
FHH/EurMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 50 1.7 g/dl 0.05 0.35 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40613 401
SS-Chr 11BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 15 2.11 g/dl 0.09 0.33 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40615 401
SS-Chr 1BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 6 1.57 g/dl 0.03 0.08 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40620 401
SS/JrHsdMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.98 g/dl 0.03 0.09 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40622 401
SS/JrHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 103.2 mmol/l 0.77 2.44 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40660 401
Hsd:SD blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 5 1.57 x 1000 cells/ul 0.4 0.9 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 40663 401
FHH-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 52.74 % 1.18 3.33 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59244 526
SHR/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 17 60.55 % 0.73 3.01 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59251 526
SS-Chr 5BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 54.24 % 0.54 1.53 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59252 526
SS-Chr 20BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 37 54.16 % 0.88 5.37 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59268 526
SS-Chr 14BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 20 52.83 % 0.8 3.57 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59293 526
FHH-Chr 19BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 54.49 % 0.47 1.49 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59310 526
SS-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 7 52.26 % 0.74 1.95 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59313 526
SS-Chr 16BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 13 59.88 % 0.64 2.32 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59315 526
FHH-Chr 13BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 54.41 % 0.5 1.59 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59317 526
SHR/NCrl serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 20 60.8 U/l 3.32 14.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40708 401
SS-Chr 13BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 11 50.91 U/l 5.68 18.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40726 401
SS-Chr 18BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 9 46.89 U/l 5.33 15.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40728 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 11 53.18 U/l 2.76 9.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40738 401
SS-Chr 2BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 15 52.33 U/l 2.24 8.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40741 401
SS-Chr 14BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 20 48.4 U/l 1.91 8.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40750 401
FHH-Chr 15BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 75.88 U/l 7.18 20.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40753 401
SS-Chr 17BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 58.88 U/l 2.54 7.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40756 401
FHH/EurMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 18 52.56 U/l 3.75 15.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40766 401
FHH-Chr 19BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 53.4 U/l 2.15 6.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40767 401
FHH-Chr 3BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 53.13 U/l 3.5 9.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40768 401
SS-Chr 3BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 7 58.71 U/l 3.84 10.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40770 401
SS-Chr 16BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 14 49.21 U/l 2.57 9.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40772 401
FHH-Chr 13BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 51.5 U/l 3.93 12.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40773 401
SS-Chr 11BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 17 41.24 U/l 3.81 15.7 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40776 401
SS-Chr XBN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 67.5 U/l 5.01 15.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40794 401
FHH-Chr 9BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 7 68.14 U/l 6.48 17.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40795 401
Hsd:SD serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 18 2.28 g/dl 0.08 0.32 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40499 401
FHH/EurMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 32.13 g/dl 0.1 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40530 401
SS-Chr 20BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 27 2.0 g/dl 0.06 0.31 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40552 401
FHH-Chr 1BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 9 1.68 g/dl 0.06 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40576 401
FHH-Chr 5BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.26 g/dl 0.06 0.16 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40580 401
SS-Chr 14BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 17 2.16 g/dl 0.07 0.3 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40582 401
SS-Chr 10BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.63 g/dl 0.03 0.11 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40590 401
SS-Chr 17BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.93 g/dl 0.07 0.2 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40592 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 23.4 mg/dl 1.88 5.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40818 401
FHH-Chr XBN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 7 28.43 mg/dl 1.54 4.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40828 401
FHH-Chr 8BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 19.8 mg/dl 1.52 4.8 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40829 401
FHH-Chr 20BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 20.8 mg/dl 0.88 2.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40834 401
SS-Chr 19BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 21.3 mg/dl 1.31 4.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40850 401
SS-Chr 2BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 12 20.08 mg/dl 1.22 4.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40855 401
FHH-Chr 15BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 26.0 mg/dl 1.78 5.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40867 401
FHH-Chr 19BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 9 22.67 mg/dl 0.97 2.92 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40885 401
FHH-Chr 11BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 22.7 mg/dl 1.22 3.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40902 401
SS-Chr 4BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 29 21.83 mg/dl 0.69 3.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40903 401
FHH-Chr 7BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 19.7 mg/dl 0.93 2.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40905 401
SS-Chr XBN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 23.2 mg/dl 1.01 3.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40908 401
FHH-Chr 7BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 23.0 mg/dl 1.03 3.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40910 401
FHH-Chr 12BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 12 4.89 x 1000 cells/ul 0.44 1.53 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40911 401
FHH-Chr 2BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 7.41 x 1000 cells/ul 1.54 4.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40913 401
FHH-Chr 2BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 6.86 x 1000 cells/ul 0.76 2.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40918 401
FHH-Chr XBN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 7 8.16 x 1000 cells/ul 0.99 2.61 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40926 401
SS-Chr 13BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 12 5.18 x 1000 cells/ul 0.26 0.91 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40933 401
FHH-Chr 4BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 6.95 x 1000 cells/ul 0.92 2.6 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40942 401
FHH-Chr 14BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 5.71 x 1000 cells/ul 0.43 1.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40957 401
SS-Chr 9BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 15 6.85 x 1000 cells/ul 0.42 1.61 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40963 401
SS-Chr 10BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 7.01 x 1000 cells/ul 0.38 1.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40966 401
SS-Chr 17BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 6.35 x 1000 cells/ul 1.03 2.92 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40968 401
FHH-Chr 16BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 9 4.76 x 1000 cells/ul 0.22 0.65 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40969 401
SS-Chr 7BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 11 8.12 x 1000 cells/ul 0.51 1.68 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40971 401
FHH-Chr 13BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 6.27 x 1000 cells/ul 0.49 1.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40986 401
SS-Chr 11BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 17 8.01 x 1000 cells/ul 0.79 3.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40988 401
SS-Chr 11BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 15 8.98 x 1000 cells/ul 0.46 1.79 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40991 401
FHH-Chr 9BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 5 5.34 x 1000 cells/ul 0.64 1.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41002 401
FHH-Chr 9BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 6 6.93 x 1000 cells/ul 0.56 1.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41007 401
SS/JrHsdMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 9 0.01 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37804 401
Hsd:SD blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 15 0.04 x 1000 cells/ul 0.01 0.05 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37805 401
Hsd:SD blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 16 0.07 x 1000 cells/ul 0.03 0.11 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37807 401
FHH-Chr 14BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 5 0.14 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59578 526
SS-Chr 6BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.16 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59580 526
SS-Chr 9BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 0.15 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59581 526
SS-Chr 17BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.13 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59594 526
GH/OmrMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 31 0.18 mmHg x min x kg x ml-1 0.01 0.05 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59596 526
FHH/EurMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 54 0.17 mmHg x min x kg x ml-1 0.0 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59610 526
FHH-Chr 12BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 12 1.77 g/kg 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59642 526
FHH-Chr 6BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.54 g/kg 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59645 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.49 g/kg 0.05 0.17 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59647 526
FHH-Chr 12BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 12 1.53 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59648 526
SS-Chr 5BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.52 g/kg 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59652 526
FHH-Chr XBN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.62 g/kg 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59653 526
FHH-Chr 10BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.47 g/kg 0.05 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59656 526
FHH-Chr 8BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.76 g/kg 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59658 526
SS-Chr 13BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 12 1.48 g/kg 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59664 526
FHH-Chr 18BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.56 g/kg 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59665 526
FHH-Chr 20BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.66 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59666 526
SS-Chr 20BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 44 1.19 g/kg 0.02 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59668 526
SS-Chr 14BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 22 1.44 g/kg 0.04 0.2 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59689 526
SS-Chr 6BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.4 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59690 526
SS-Chr 20BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 31.74 g/dl 0.17 0.47 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41115 401
WKY/NCrl serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 20.25 mmol/l 1.33 3.77 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41121 401
LEW/Crl serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 16.6 mmol/l 0.88 2.8 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41122 401
F344/DuCrl serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 18 14.61 mmol/l 0.38 1.61 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41124 401
LE/BluGill serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 15.1 mmol/l 0.67 2.13 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41130 401
FHH-Chr 6BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 18.32 g/dl 0.2 0.63 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37956 401
SS-Chr 5BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 17.27 g/dl 0.21 0.58 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37963 401
SS-Chr 5BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 17.76 g/dl 0.1 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37966 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 19.01 g/dl 0.14 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37992 401
SS-Chr 10BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 18.31 g/dl 0.22 0.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37997 401
SS-Chr 6BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 19.73 g/dl 0.41 1.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38006 401
SS-Chr 11BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 17 16.98 g/dl 0.34 1.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38030 401
FHH-Chr 11BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 17.66 g/dl 0.39 1.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38041 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 14 4.51 mmol/l 0.2 0.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38052 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.14 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59533 526
SHR/NCrl calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 22 0.13 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59541 526
FHH-Chr 4BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.16 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59563 526
FHH-Chr 3BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 9 1.8 g/kg 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59711 526
FHH-Chr 3BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.67 g/kg 0.09 0.3 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59721 526
FHH-Chr 9BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.66 g/kg 0.06 0.19 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59738 526
FHH/EurMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 7 9.52 x 10E6 cells/ul 0.16 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 37916 401
FHH/EurMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 7 9.92 x 10E6 cells/ul 0.3 0.79 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 37919 401
SS-Chr 15BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 5.05 mmol/l 0.15 0.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38069 401
FHH-Chr 20BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.18 mmol/l 0.14 0.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38075 401
FHH-Chr YBN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 4.58 mmol/l 0.13 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38079 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 5 5.14 mmol/l 0.37 0.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38090 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 159.6 mg/dl 8.38 26.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38520 401
FHH-Chr 10BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 7 147.0 mg/dl 8.78 23.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38523 401
SHR/NCrl serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 20 156.05 mg/dl 4.51 20.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38524 401
FHH-Chr 2BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.14 x 1000 cells/ul 0.04 0.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41634 401
FHH-Chr XBN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 7 0.07 x 1000 cells/ul 0.02 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41647 401
FHH-Chr 20BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.06 x 1000 cells/ul 0.03 0.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41653 401
FHH-Chr 20BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.11 x 1000 cells/ul 0.05 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41656 401
SS-Chr 20BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 33 0.02 x 1000 cells/ul 0.01 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41658 401
SS-Chr 13BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 11 0.04 x 1000 cells/ul 0.01 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41659 401
SS-Chr 18BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.03 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41661 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 7 0.05 x 1000 cells/ul 0.02 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41666 401
SS-Chr 19BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41667 401
SS-Chr 2BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.03 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41670 401
FHH-Chr 3BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.25 mmol/l 0.13 0.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38120 401
SS-Chr 16BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 12 4.47 mmol/l 0.2 0.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38121 401
FHH-Chr 19BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.5 mmol/l 0.27 0.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38123 401
FHH-Chr 13BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.13 mmol/l 0.11 0.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38125 401
SS-Chr 3BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 6 4.32 mmol/l 0.27 0.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38127 401
SS-Chr 11BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 17 4.51 mmol/l 0.11 0.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38128 401
SS-Chr 11BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 15 5.19 mmol/l 0.13 0.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38131 401
SS-Chr YBN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 17 5.05 mmol/l 0.07 0.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38132 401
FHH-Chr 9BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 4.6 mmol/l 0.2 0.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38147 401
WKY/NCrl red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 10.14 x 10E6 cells/ul 0.3 0.84 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38149 401
F344/DuCrl red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 14 10.33 x 10E6 cells/ul 0.16 0.61 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38152 401
LE/BluGill red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 9 9.62 x 10E6 cells/ul 0.12 0.35 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38154 401
SS-Chr 16BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 6 60.03 fl 0.37 0.9 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38166 401
F344/DuCrl serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 17 110.0 mmol/l 1.06 4.39 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38188 401
SS/JrHsdMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 2 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38196 401
SS/JrHsdMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 3 0.04 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38201 401
WKY/NCrl blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 2.61 x 1000 cells/ul 0.53 1.5 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38214 401
SS-Chr 16BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 7 10.36 x 1000 cells/ul 0.89 2.34 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41485 401
FHH-Chr 2BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 5.18 x 1000 cells/ul 0.62 1.75 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41495 401
FHH-Chr 10BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 7 7.77 x 1000 cells/ul 0.79 2.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41496 401
FHH-Chr 8BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 4.48 x 1000 cells/ul 0.2 0.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41504 401
SS-Chr 20BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 33 7.42 x 1000 cells/ul 0.26 1.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41514 401
SS-Chr 19BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 4.74 x 1000 cells/ul 0.16 0.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41525 401
SS-Chr 6BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 3.35 x 1000 cells/ul 0.46 1.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41536 401
FHH-Chr 5BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 4.83 x 1000 cells/ul 0.42 1.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41538 401
SS-Chr 6BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 7 5.47 x 1000 cells/ul 0.82 2.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41541 401
FHH-Chr 19BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 5.91 x 1000 cells/ul 0.4 1.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41556 401
SS-Chr 3BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 7 4.58 x 1000 cells/ul 0.68 1.79 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41564 401
Crl:CD(SD) serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 9 55.44 U/l 2.84 8.52 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41600 401
LEW/Crl serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 48.8 U/l 2.74 8.68 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41604 401
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 3 56.27 % 1.39 2.41 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38359 401
FHH/EurMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 7 109.14 mmol/l 0.8 2.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 38410 401
FHH-Chr 2BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 20.63 mmol/l 0.98 2.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38248 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 22.9 mmol/l 0.57 1.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38251 401
SS-Chr 5BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 17.88 mmol/l 0.61 1.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38256 401
FHH-Chr 20BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 21.6 mmol/l 0.52 1.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38267 401
FHH-Chr 18BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 18.2 mmol/l 0.7 2.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38269 401
SS-Chr 18BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 20.5 mmol/l 0.7 2.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38275 401
SS-Chr 19BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 21.0 mmol/l 0.6 1.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38281 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 11 27.36 mmol/l 0.78 2.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38285 401
FHH-Chr 5BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 17.88 mmol/l 0.4 1.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38296 401
SS-Chr 10BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 16.2 mmol/l 0.77 2.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38301 401
GH/OmrMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 15 24.6 mmol/l 0.54 2.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38305 401
SS-Chr 7BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 12 17.0 mmol/l 1.24 4.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38311 401
FHH-Chr 15BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.07 x 1000 cells/ul 0.02 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41675 401
SS-Chr 7BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 11 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41692 401
SS-Chr 7BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 12 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41697 401
FHH/EurMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 49 0.03 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41710 401
SS-Chr 4BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 26 0.01 x 1000 cells/ul 0.0 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41718 401
FHH-Chr 11BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41721 401
SS-Chr XBN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41727 401
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 0.51 IU/g 0.21 0.47 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47461 461
SS-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 21 0.44 IU/g 0.06 0.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47468 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.31 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47482 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 14 0.29 IU/g 0.07 0.25 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47487 461
SS-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.23 IU/g 0.05 0.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47489 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 19 0.46 IU/g 0.12 0.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47491 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 12 0.33 IU/g 0.07 0.23 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47503 461
SS-Chr XBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 11 0.59 IU/g 0.08 0.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47507 461
FHH/EurMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 47.87 % 9.4 24.86 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47513 461
GH/OmrMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 56.6 % 5.4 13.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47515 461
GH/OmrMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 54.46 % 9.53 28.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47519 461
Crl:CD(SD) percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 27.46 % 7.86 24.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47522 461
F344/DuCrl percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 30.78 % 5.81 17.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47523 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 6.14 mmHg 0.8 2.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 47537 461
SS/JrHsdMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 4 66.25 mmHg 8.33 16.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47563 461
SS-Chr 18BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 55.13 mmHg 3.01 8.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47565 461
FHH-Chr 3BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 6 145.17 mg/dl 4.77 11.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38594 401
SS/JrHsdMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 95 150.75 mg/dl 2.11 20.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38597 401
FHH-Chr 7BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 155.1 mg/dl 10.51 33.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38612 401
SS-Chr 20BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 7 140.0 mg/dl 12.54 33.18 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38626 401
SS/JrHsdMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 141.8 mg/dl 10.29 32.53 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38628 401
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 266.65 beats/min 6.08 17.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47580 461
SS-Chr 15BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 269.09 beats/min 10.68 33.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47585 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 12 234.91 beats/min 5.87 20.34 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47601 461
SS-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 241.02 beats/min 10.44 33.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47607 461
SS-Chr 14BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 19 273.59 beats/min 10.1 44.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47618 461
FHH-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 20 252.87 beats/min 5.26 23.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47632 461
FHH-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 221.87 beats/min 11.62 25.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47635 461
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 257.14 beats/min 8.39 25.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47637 461
FHH-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 204.56 beats/min 15.67 44.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47645 461
SS-Chr 1BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 263.56 beats/min 5.53 15.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47649 461
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 23 264.61 beats/min 9.44 45.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47660 461
WKY/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 147.44 mmHg 6.89 20.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47664 461
SS/JrHsdMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 64.42 % 11.06 34.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48499 461
FHH-Chr 10BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 49.86 % 5.11 10.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48520 461
SHR/NCrl percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 38.2 % 6.22 21.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48524 461
FHH-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 43.14 % 2.38 6.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48535 461
FHH-Chr 20BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 47.6 % 4.84 14.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48536 461
SS-Chr 20BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 23 post-ischemic value/pre-ischemic value x 100% 18.25 % 3.37 16.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48538 461
SS-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 26.4 % 7.86 23.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48541 461
FHH-Chr 4BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 35.13 % 5.51 13.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48543 461
FHH-Chr 4BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 31.2 % 5.0 14.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48545 461
SS-Chr 19BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 24.27 % 5.17 13.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48547 461
SS-Chr 2BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 54.93 % 5.3 16.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48550 461
SS-Chr 12BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 33.39 % 3.14 9.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48552 461
SS-Chr 2BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 42.51 % 4.93 15.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48554 461
FHH-Chr 14BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 32.87 % 7.74 18.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48568 461
FHH-Chr 16BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 38.43 % 4.55 15.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48570 461
SS-Chr 7BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 31.47 % 8.26 18.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48572 461
FHH-Chr 19BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 44.33 % 9.97 31.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48579 461
SS-Chr 4BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 42.78 % 4.96 14.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48597 461
SS/JrHsdMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 38.73 % 6.03 20.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48598 461
FHH-Chr 7BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 40.61 % 8.64 27.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48608 461
FHH-Chr 8BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 117.22 mmHg 7.37 16.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48629 461
FHH-Chr 15BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 100.23 mmHg 9.96 24.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48652 461
SS-Chr 14BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 99.02 mmHg 6.6 21.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48656 461
GH/OmrMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 168.85 mmHg 10.18 32.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48668 461
SS-Chr 7BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 135.65 mmHg 9.45 21.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48669 461
SS-Chr 7BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 129.97 mmHg 5.02 15.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48673 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 12 117.36 mmHg 4.86 16.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48675 461
SS-Chr 11BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 111.7 mmHg 6.77 26.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48685 461
SS-Chr YBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 19 132.35 mmHg 5.04 21.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48689 461
FHH-Chr 7BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 109.79 mmHg 8.08 25.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48705 461
SS-Chr 18BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 12.37 % 4.23 11.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48708 461
SS-Chr 16BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 83.16 mmHg 4.37 12.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48727 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 92.0 mmHg 7.24 20.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48729 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 137.71 mmHg 7.66 20.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48732 461
GH/OmrMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 214.57 mmHg 18.48 48.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48734 461
SS-Chr 16BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 138.85 mmHg 3.74 11.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48735 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 122.57 mmHg 3.05 8.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48737 461
FHH-Chr 11BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.14 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41942 401
FHH-Chr 2BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.79 g 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45392 461
SS-Chr 5BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.91 g 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45403 461
FHH-Chr 20BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 1.03 g 0.07 0.24 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45411 461
FHH-Chr 18BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 0.84 g 0.07 0.21 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45413 461
FHH-Chr YBN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 14 0.65 g 0.02 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45418 461
SS-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 49.04 mmHg 6.1 19.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46444 461
SS-Chr 10BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 50.19 mmHg 3.23 9.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46446 461
SS-Chr 10BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 47.58 mmHg 4.38 13.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46457 461
GH/OmrMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 33.27 mmHg 6.92 21.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46461 461
FHH-Chr 19BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 43.53 mmHg 4.55 14.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46469 461
SS-Chr 16BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 21 55.44 mmHg 3.42 15.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46471 461
FHH-Chr 19BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 37.12 mmHg 4.38 13.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46473 461
FHH-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 51.53 mmHg 6.31 17.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46475 461
SS-Chr 1BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 52.11 mmHg 7.45 21.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46484 461
FHH-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 54.86 mmHg 4.05 9.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46490 461
SS-Chr XBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 32.08 mmHg 4.36 14.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46496 461
LEW/Crl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 213.87 beats/min 14.27 45.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46500 461
Crl:CD(SD) heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 245.03 beats/min 30.09 95.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46503 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 6 349.16 beats/min 39.15 95.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46512 461
SS-Chr 2BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.92 g 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45428 461
SS-Chr 12BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.83 g 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45430 461
SS-Chr 2BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.95 g 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45432 461
SS-Chr 10BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.95 g 0.05 0.17 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45445 461
SS-Chr 16BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 23 1.06 g 0.03 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45462 461
FHH/EurMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 60 1.0 g 0.04 0.31 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45467 461
SS-Chr 11BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 25 0.91 g 0.03 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45469 461
FHH-Chr 11BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.99 g 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45477 461
FHH-Chr 11BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.82 g 0.06 0.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45478 461
FHH-Chr 12BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 12 0.12 mg/dl 0.01 0.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41853 401
FHH-Chr 6BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41856 401
SS-Chr 2BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 15 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41895 401
FHH-Chr 16BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 9 0.12 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41911 401
FHH-Chr 17BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 6 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41916 401
FHH-Chr 16BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 9 0.09 mg/dl 0.01 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41919 401
SS-Chr 16BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 14 0.15 mg/dl 0.02 0.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41926 401
SS-Chr 3BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 6 0.15 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41929 401
SS-Chr 1BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 6 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41938 401
SS/JrHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.13 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41940 401
SS-Chr 13BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 11 151.09 mg/dl 5.96 19.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38542 401
GH/OmrMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 1111.18 s 116.44 308.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48925 461
SS-Chr YBN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 19 9.81 ml/min/kg 0.43 1.87 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57664 526
SS-Chr 1BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 15.12 ml/min/kg 0.4 1.25 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57666 526
SS-Chr XBN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 14 13.08 ml/min/kg 0.77 2.87 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57667 526
SS/JrHsdMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 10.26 ml/min/kg 0.57 1.61 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57670 526
FHH-Chr 11BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 18.14 ml/min/kg 1.58 3.88 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57672 526
FHH-Chr 7BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 16.95 ml/min/kg 0.49 1.21 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57675 526
BN/NHsdMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 27 20.64 ml/min/kg 1.27 6.61 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57677 526
LE/BluGill calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 13 0.16 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57686 526
FHH/EurMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 3 14.05 ml/min/kg 0.89 1.54 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 57715 526
Crl:CD(SD) dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 2.85 mg/kg 0.98 2.6 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57765 526
Hsd:SD calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 0.12 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57773 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 10.34 ml/min/kg 0.51 1.44 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57786 526
FHH-Chr 2BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 25.83 ml/min/kg 1.16 3.47 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57787 526
SS-Chr 5BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 21.14 ml/min/kg 0.92 2.59 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57798 526
SS-Chr 11BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 17 18.82 ml/min/kg 1.0 4.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57660 526
FHH-Chr 6BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 76.15 % 4.33 12.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48745 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 70.53 % 6.49 24.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48746 461
FHH-Chr XBN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 82.07 % 5.61 14.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48752 461
FHH-Chr XBN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 84.27 % 8.35 23.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48756 461
FHH-Chr 20BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 84.71 % 3.58 10.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48765 461
FHH-Chr 4BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 83.62 % 5.54 16.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48774 461
SS-Chr 19BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 75.9 % 11.78 31.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48776 461
FHH-Chr 15BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 70.79 % 12.12 29.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48784 461
SS-Chr 7BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 76.39 % 7.1 18.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48801 461
SS-Chr 3BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 86.88 % 6.39 19.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48811 461
FHH/EurMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 42 post-ischemic value/pre-ischemic value x 100% 78.72 % 2.67 17.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48818 461
SS-Chr 4BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 87.22 % 6.46 24.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48830 461
BN/NHsdMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 22 post-ischemic value/pre-ischemic value x 100% 76.24 % 3.86 18.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48834 461
FHH-Chr 9BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 63.26 % 8.19 24.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48836 461
LEW/Crl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 16 372.75 beats/min 13.56 54.23 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16123 381
Crl:CD(SD) heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 389.59 beats/min 19.9 52.64 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16124 381
WKY/NCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 15 356.09 beats/min 15.89 61.56 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16129 381
Crl:CD(SD) lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.03 g/kg 0.05 0.15 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57575 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 11.16 ml/min/kg 0.64 1.93 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57588 526
FHH-Chr 10BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 15.77 ml/min/kg 1.09 3.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57597 526
FHH-Chr 20BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 15.18 ml/min/kg 0.59 1.86 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57604 526
FHH-Chr 5BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 15.58 ml/min/kg 1.5 4.49 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57628 526
SS-Chr 17BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 14.52 ml/min/kg 1.02 3.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57640 526
FHH-Chr 17BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 17.33 ml/min/kg 0.48 1.51 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57644 526
GH/OmrMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 21 8.6 ml/min/kg 0.51 2.35 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57647 526
GH/OmrMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 20 10.9 ml/min/kg 0.86 3.82 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57849 526
FHH-Chr 19BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 24.31 ml/min/kg 1.27 4.01 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57853 526
SS-Chr 16BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 13 12.05 ml/min/kg 0.92 3.31 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57855 526
SS-Chr 16BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 9.23 ml/min/kg 0.59 2.04 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57858 526
SS-Chr XBN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 14 20.35 ml/min/kg 0.98 3.66 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57869 526
SS-Chr XBN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 20.29 ml/min/kg 0.9 2.84 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57880 526
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 4 1.42 mg/kg 0.31 0.63 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57983 526
FHH-Chr 4BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 27.63 ml/min/kg 1.63 4.61 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57818 526
SS-Chr 12BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 26.82 ml/min/kg 2.11 6.32 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57821 526
SS-Chr 19BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 27.39 ml/min/kg 1.43 4.51 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57822 526
SS-Chr 14BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 18 29.19 ml/min/kg 0.92 3.91 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57832 526
SS-Chr 14BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 18 22.73 ml/min/kg 0.84 3.57 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57836 526
FHH-Chr 14BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 25.55 ml/min/kg 2.46 6.96 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57841 526
GH/OmrMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 21 13.19 ml/min/kg 0.8 3.64 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57844 526
FHH-Chr 17BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 25.45 ml/min/kg 1.09 3.45 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57846 526
SHR/NCrl FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 11 36.66 ml/min/kg 2.94 9.76 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57993 526
FHH-Chr XBN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 65.73 ml/min/kg 5.7 13.95 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57999 526
FHH-Chr 8BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 54.63 ml/min/kg 4.0 12.64 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58000 526
FHH-Chr 20BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 52.28 ml/min/kg 3.39 10.71 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58005 526
SS-Chr 13BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 37.61 ml/min/kg 1.89 5.98 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58011 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 51.3 ml/min/kg 2.24 6.73 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58018 526
FHH-Chr 5BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 49.94 ml/min/kg 6.99 20.96 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58029 526
FHH-Chr 14BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 5 59.0 ml/min/kg 5.23 11.69 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58030 526
SS-Chr 6BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 36.33 ml/min/kg 5.47 16.4 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58032 526
SS-Chr 9BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 15 37.9 ml/min/kg 4.99 19.34 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58033 526
SS-Chr 14BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 43.7 ml/min/kg 1.92 7.92 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58035 526
GH/OmrMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 18 28.94 ml/min/kg 2.39 10.14 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58048 526
FHH-Chr 19BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 57.6 ml/min/kg 5.55 17.56 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58052 526
FHH-Chr 13BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 36.89 degrees C 0.14 0.47 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16633 381
SS-Chr 1BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 38.78 degrees C 0.13 0.41 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16641 381
SS-Chr XBN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 37.48 degrees C 0.16 0.55 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16642 381
SS-Chr 4BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 37.12 degrees C 0.15 0.51 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16644 381
F344/DuCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 25.74 mmHg 0.89 2.51 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16366 381
F344/DuCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 26.21 mmHg 0.43 1.05 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16371 381
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 28.01 mmHg 0.79 2.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16451 381
SS-Chr 20BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 7 0.35 null 0.04 0.11 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58314 526
SS-Chr 20BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 9 0.34 null 0.04 0.12 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58317 526
SS-Chr 20BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 8 180.6 g 2.2 6.2 whole body digital scale 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58432 526
SS/JrHsdMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 10.93 ml/min/kg 1.56 4.41 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58467 526
SS-Chr 16BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 24.94 ml/min/kg 1.52 4.82 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58057 526
SS-Chr 11BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 16 76.65 ml/min/kg 6.38 25.51 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58061 526
FHH/EurMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 52 43.96 ml/min/kg 2.44 17.56 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58062 526
SS-Chr 11BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 51.78 ml/min/kg 3.45 14.21 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58064 526
SS-Chr 1BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 72.02 ml/min/kg 6.67 21.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58067 526
SS-Chr 4BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 22 53.43 ml/min/kg 3.08 14.43 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58070 526
WKY/NCrl fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58089 526
SS-Chr 20BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 7 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58092 526
SHR/NCrl methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.48 null 0.1 0.33 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58110 526
SS-Chr 5BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.5 null 0.03 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58111 526
FHH-Chr 18BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.45 null 0.03 0.07 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58121 526
FHH-Chr 4BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.55 null 0.03 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58129 526
SS-Chr 2BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 0.37 null 0.03 0.12 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58140 526
FHH-Chr 15BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.34 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58152 526
FHH-Chr 14BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.47 null 0.05 0.15 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58154 526
SS-Chr 7BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 0.43 null 0.02 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58158 526
FHH-Chr 17BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.43 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58159 526
FHH-Chr 17BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.53 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58161 526
SS-Chr 7BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 0.51 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58163 526
FHH-Chr 16BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.47 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58164 526
SS-Chr 16BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.35 null 0.02 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58171 526
FHH/EurMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 51 0.53 null 0.04 0.28 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58176 526
FHH-Chr 7BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.39 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58195 526
SS-Chr 16BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 7 55.66 % 1.06 2.8 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Dyets 58201 526
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 7 58.54 % 1.94 5.14 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Dyets 58202 526
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 4 55.68 % 1.15 2.3 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Dyets 58203 526
FHH-Chr 2BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.76 degrees C 0.16 0.5 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16559 381
SS-Chr 15BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.12 degrees C 0.2 0.62 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16576 381
FHH-Chr 20BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 36.89 degrees C 0.12 0.37 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16581 381
FHH-Chr 15BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.03 mmHg-1 0.01 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58517 526
SS-Chr 10BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58518 526
SS-Chr 14BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 19 0.03 mmHg-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58521 526
SS-Chr 9BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 16 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58523 526
FHH-Chr 15BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.02 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58528 526
SS-Chr 17BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58531 526
SS-Chr 7BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 12 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58539 526
SS-Chr 16BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 14 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58544 526
FHH-Chr 13BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58549 526
FHH-Chr 9BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 6 0.02 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58565 526
SS-Chr XBN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58569 526
WKY/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 60.23 % 1.66 4.7 microhematocrit tube assay with visual assessment 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58582 526
F344/DuCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 11 59.93 % 0.64 2.13 microhematocrit tube assay with visual assessment 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58590 526
FHH-Chr 10BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 7 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58482 526
SS-Chr 13BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 12 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58496 526
FHH-Chr 1BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 13 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58504 526
FHH-Chr 4BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 8 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58507 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58508 526
FHH-Chr 11BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.53 null 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58807 526
FHH-Chr 9BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.48 null 0.04 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58809 526
SS-Chr 16BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 7 294.3 g 5.7 15.1 whole body digital scale 0 Moms and pups used in studies were fed Dyets 58821 526
SS/JrHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 11 209.2 g 3.6 11.9 whole body digital scale 0 Moms and pups used in studies were fed Dyets 58823 526
F344/DuCrl methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 13 15.9 ml/min/kg 1.49 5.37 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58842 526
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 1.61 mg/kg 0.31 0.83 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58881 526
SS-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 0.61 mg/kg 0.14 0.38 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58882 526
SS-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.59 mg/kg 0.55 1.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58901 526
FHH-Chr 10BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 6 2.21 mg/kg 0.55 1.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58905 526
SS-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.09 mg/kg 0.23 0.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58909 526
FHH-Chr 1BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 13 2.78 mg/kg 0.54 1.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58921 526
SS-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.46 mg/kg 0.22 0.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58923 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.2 mg/kg 0.25 0.71 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58925 526
LEW/Crl heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.47 null 0.02 0.08 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59972 526
SS-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 16 1.02 mg/kg 0.19 0.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58968 526
Hsd:SD methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 19.67 ml/min/kg 1.66 4.07 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58708 526
FHH-Chr 12BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 12 0.49 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58718 526
FHH-Chr 12BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 11 0.52 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58724 526
FHH-Chr 2BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.55 null 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58725 526
SHR/NCrl heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 24 0.32 null 0.01 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58730 526
FHH-Chr 10BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.48 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58732 526
FHH-Chr 20BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.6 null 0.05 0.17 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58739 526
SS-Chr 6BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.35 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58766 526
FHH-Chr 16BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 9 0.42 null 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58784 526
FHH/EurMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 64 0.43 null 0.02 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58796 526
SS-Chr YBN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 20 0.37 null 0.01 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58799 526
LE/BluGill body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 14 203.5 g 9.5 35.6 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60101 526
Crl:CD(SD) FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 25.22 ml/min/kg 2.27 5.99 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60130 526
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 48.14 ml/min 2.83 10.98 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17467 381
SS-Chr 16BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 24 9.7 ml/min/g 0.43 2.09 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46707 461
FHH-Chr 19BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 12.26 ml/min/g 0.95 2.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46709 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 9.12 ml/min/g 0.68 2.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46713 461
SS-Chr YBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 28 11.9 ml/min/g 0.51 2.72 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46718 461
SS-Chr 1BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 8.62 ml/min/g 0.48 1.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46722 461
BN/NHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 22 17.81 ml/min/g 0.68 3.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46730 461
LEW/Crl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 144.93 mmHg 6.02 19.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47671 461
LE/BluGill left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 134.56 mmHg 4.79 12.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47675 461
Crl:CD(SD) left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 34.85 mmHg 9.36 29.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45903 461
FHH/EurMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 91.06 % 7.2 16.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45927 461
Crl:CD(SD) left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 56.35 mmHg 5.11 16.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45933 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 49.4 mmHg 11.63 20.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45936 461
LE/BluGill left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 43.49 mmHg 6.61 19.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45942 461
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 14.02 IU/g 2.17 6.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45991 461
FHH-Chr 4BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 13.64 IU/g 2.07 5.85 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45997 461
FHH-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 11.3 IU/g 1.12 3.55 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46001 461
FHH-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 20.84 IU/g 1.94 6.12 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46008 461
FHH-Chr 10BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 4 8.54 ml/min/g 1.1 2.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44711 461
SHR/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 5.44 ml/min/g 0.5 1.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44712 461
FHH-Chr XBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 4.2 ml/min/g 0.25 0.71 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44718 461
SS-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 6.79 ml/min/g 0.39 1.6 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44730 461
SS-Chr 6BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 4.9 ml/min/g 0.3 0.89 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44751 461
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 177.0 mmHg 9.32 26.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45814 461
FHH/EurMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 7 1.46 g 0.05 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 45827 461
FHH/EurMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 7 611.92 s 56.78 150.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45835 461
GH/OmrMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 7 641.83 s 47.92 126.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45837 461
FHH/EurMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 7 761.08 s 60.27 159.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45839 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 152.8 mmHg 8.32 18.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45866 461
FHH-Chr 6BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 16 6.85 g/kg 0.31 1.23 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45597 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 15 5.93 g/kg 0.17 0.66 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45600 461
FHH-Chr 17BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 20 6.9 g/kg 0.31 1.39 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45619 461
FHH-Chr XBN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 6.31 g/kg 0.33 1.03 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45621 461
SS-Chr 5BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 5.18 g/kg 0.19 0.61 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45623 461
FHH-Chr 8BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 6.82 g/kg 0.26 0.83 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45627 461
SS-Chr 16BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 20 5.31 g/kg 0.17 0.74 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45637 461
SS-Chr 11BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 25 5.31 g/kg 0.14 0.72 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45654 461
SS-Chr XBN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 12 5.85 g/kg 0.29 1.02 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45658 461
FHH-Chr 4BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 6.6 g/kg 0.31 0.98 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45666 461
SS-Chr 2BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 6.99 g/kg 0.1 0.33 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45675 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 3 10.97 IU/g 0.8 1.38 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45702 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 136.86 mmHg 4.19 15.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45719 461
FHH-Chr 20BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 125.94 mmHg 4.99 14.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45738 461
FHH-Chr 1BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 148.32 mmHg 6.53 20.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45744 461
SS-Chr 19BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 101.7 mmHg 5.34 15.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45749 461
SS-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 92.13 mmHg 3.86 12.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45754 461
FHH-Chr 15BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 105.2 mmHg 9.77 23.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45757 461
FHH-Chr 17BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 122.08 mmHg 4.5 14.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45775 461
SS-Chr 17BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 103.91 mmHg 4.77 14.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45776 461
SS-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 135.21 mmHg 4.98 14.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45778 461
FHH-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 124.4 mmHg 5.33 16.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45801 461
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 10.71 ml/min/g 0.51 1.92 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46638 461
FHH-Chr 6BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 9.89 ml/min/g 0.58 1.65 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46642 461
SS-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 11.18 ml/min/g 0.54 1.72 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46674 461
SS-Chr 9BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 17 11.66 ml/min/g 0.62 2.57 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46690 461
SS-Chr 17BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 12.04 ml/min/g 0.79 2.51 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46695 461
WKY/NCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 53.59 % 3.91 11.74 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47882 461
Crl:CD(SD) percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 67.84 % 7.4 23.42 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47886 461
LE/BluGill percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 57.9 % 5.02 15.07 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47888 461
FHH/EurMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 5 15.32 % 6.67 14.91 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47998 461
FHH/EurMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 5 14.34 % 2.21 4.94 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48000 461
SS/JrHsdMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 14.78 % 14.78 29.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48002 461
SS-Chr 18BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 53.61 % 8.2 23.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48004 461
Crl:CD(SD) left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.73 mmHg 0.11 0.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48008 461
F344/DuCrl time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1125.42 s 55.97 177.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45111 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 10.17 IU/g 0.68 1.66 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45113 461
FHH-Chr 10BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 4 173.36 beats/min 23.58 47.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45141 461
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 187.87 beats/min 11.71 35.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45143 461
FHH-Chr 8BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 196.96 beats/min 9.21 27.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45153 461
FHH-Chr YBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 202.79 beats/min 16.98 53.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45161 461
SS-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 227.39 beats/min 5.69 18.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45169 461
SS-Chr 19BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 210.35 beats/min 11.22 31.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45170 461
FHH-Chr 15BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 159.95 beats/min 16.39 46.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45176 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 10.76 ml/min/g 0.87 2.76 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46284 461
FHH-Chr 12BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 89.28 % 19.25 66.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48286 461
WKY/NCrl heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 1.09 g 0.04 0.13 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45028 461
LEW/Crl heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 1.1 g 0.03 0.1 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45029 461
Crl:CD(SD) heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 1.27 g 0.04 0.13 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45030 461
Crl:CD(SD) heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 1.03 g 0.04 0.12 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45032 461
LE/BluGill heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 11 0.96 g 0.1 0.34 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45034 461
WKY/NCrl heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 1.0 g 0.06 0.18 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45036 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 11 12.69 ml/min/g 1.22 4.04 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45053 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 60.29 mmHg 2.65 7.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45055 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 3 9.7 ml/min/g 0.85 1.47 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45090 461
SS-Chr 16BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 6.1 ml/min/g 1.23 3.47 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45097 461
FHH-Chr 6BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 48.07 mmHg 5.28 16.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46405 461
FHH-Chr 8BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 34.13 mmHg 5.42 16.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46422 461
FHH-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 4.91 mmHg 0.41 1.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47255 461
FHH-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.45 mmHg 0.38 1.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47260 461
SS-Chr YBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 24 4.91 mmHg 0.22 1.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47262 461
SS-Chr 1BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 4.46 mmHg 0.65 1.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47264 461
FHH-Chr 1BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 49.61 % 2.83 8.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47103 461
FHH-Chr 5BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 40.29 % 4.67 13.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47112 461
SS-Chr 14BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 59.4 % 3.47 15.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47113 461
GH/OmrMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 53.44 % 5.49 14.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47121 461
SS-Chr 17BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 57.46 % 4.55 13.65 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47124 461
FHH-Chr 17BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 52.79 % 4.3 17.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47125 461
SS-Chr 11BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 22 post-ischemic value/pre-ischemic value x 100% 52.71 % 3.79 17.78 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47141 461
SS-Chr 4BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 post-ischemic value/pre-ischemic value x 100% 66.81 % 6.88 28.37 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47147 461
SS-Chr 20BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 23 5.89 mmHg 0.09 0.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47199 461
SS-Chr 15BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 5.19 mmHg 0.18 0.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47201 461
FHH-Chr 1BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.18 mmHg 0.28 0.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47212 461
SS-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 6.11 mmHg 0.15 0.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47224 461
FHH-Chr 19BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.77 mmHg 0.35 1.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47253 461
WKY/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 9.07 ml/min/g 0.56 1.76 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46182 461
FHH-Chr 2BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 25.13 % 1.46 4.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47069 461
SHR/NCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 58.26 % 4.16 13.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47071 461
SS-Chr 5BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 47.71 % 4.02 11.37 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47075 461
SS-Chr 15BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 41.53 % 2.44 7.73 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47080 461
FHH-Chr 20BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 35.61 % 2.71 8.12 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47086 461
FHH-Chr YBN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 51.19 % 3.43 10.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47090 461
SS-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 57.19 % 4.21 15.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47094 461
SS-Chr 16BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 21 7.38 ml/min/g 1.47 6.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44772 461
FHH-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 3.1 ml/min/g 0.18 0.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44790 461
FHH/EurMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 113.74 % 29.64 78.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46032 461
WKY/NCrl time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 955.43 s 64.85 183.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48118 461
LEW/Crl time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 836.59 s 16.25 51.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48125 461
Hsd:SD time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 3 102.04 s 0.0 0.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48127 461
LE/BluGill time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 924.89 s 92.89 278.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48129 461
SS-Chr 16BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 10.57 % 3.18 10.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48134 461
SS-Chr 14BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 18 255.2 beats/min 15.17 64.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45184 461
SS-Chr 9BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 17 182.57 beats/min 26.06 107.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45182 461
SS-Chr 9BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 17 256.37 beats/min 35.95 148.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45185 461
FHH-Chr 14BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 204.34 beats/min 11.08 27.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45189 461
SS-Chr 17BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 217.7 beats/min 8.63 25.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45195 461
SS-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 312.71 beats/min 57.23 180.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45197 461
FHH-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 272.88 beats/min 47.09 133.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45206 461
SS-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 23 237.4 beats/min 18.95 90.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45212 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 89 209.31 beats/min 4.76 44.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45214 461
FHH-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 199.74 beats/min 14.67 46.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45224 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 284.37 beats/min 31.65 89.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45253 461
FHH-Chr XBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 41.5 mmHg 3.88 10.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45266 461
SS-Chr 15BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 49.91 mmHg 4.4 11.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45274 461
SS-Chr 13BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 18 58.08 mmHg 4.6 19.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45277 461
SS-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 28.99 mmHg 2.96 9.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45295 461
SS-Chr 10BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 51.45 mmHg 4.44 13.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45299 461
FHH-Chr 19BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 46.12 mmHg 10.04 31.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45322 461
SS-Chr 16BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 21 43.35 mmHg 4.57 20.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45324 461
SS-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 22.73 mmHg 5.51 16.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45325 461
SS-Chr 11BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 19 52.41 mmHg 5.05 21.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45331 461
SS-Chr 1BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 19.13 mmHg 4.33 12.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45337 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 114.36 mmHg 4.32 13.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45372 461
SS-Chr 18BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 8 1.67 g 0.07 0.2 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45380 461
FHH/EurMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 5 1007.72 s 59.97 134.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45387 461
FHH-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 4 0.39 IU/g 0.19 0.39 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47425 461
FHH-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 0.43 IU/g 0.1 0.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47440 461
FHH-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 20 0.34 IU/g 0.03 0.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47444 461
GH/OmrMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.37 IU/g 0.07 0.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47446 461
SHR/NCrl percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 62.41 % 11.33 45.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48292 461
FHH-Chr 18BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 89.29 % 4.55 13.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48305 461
FHH-Chr YBN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 80.78 % 6.67 21.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48308 461
SS-Chr 2BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 83.27 % 4.0 12.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48318 461
SS-Chr 2BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 86.63 % 3.63 11.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48322 461
SS-Chr 6BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 78.64 % 3.84 11.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48328 461
FHH-Chr 19BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 99.49 % 17.68 55.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48347 461
FHH-Chr 19BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 114.05 % 23.76 75.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48351 461
FHH-Chr 11BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 67.89 % 4.91 14.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48367 461
SS-Chr XBN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 89.77 % 3.04 10.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48374 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 3 0.02 IU/g 0.01 0.01 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48382 461
LE/BluGill heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.39 IU/g 0.07 0.21 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48388 461
Crlj:WI body weight controlled air oxygen content (21 %) (for 28 days) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. body mass male 16 days 6 322.0 g 6.0 14.7 body weighing method 0.0 0 102999 2784
Crlj:WI heart left ventricle weight to body weight ratio controlled air oxygen content (5 %) (for 28 days) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart left ventricle mass male 16 days 7 1.74 mg/g 0.11 0.29 post excision weight measurement 0.0 0 103008 2784
Crlj:WI heart right ventricle weight to body weight ratio controlled air oxygen content (21 %) (for 28 days) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart right ventricle mass male 16 days 6 0.29 mg/g 0.02 0.05 post excision weight measurement 0.0 0 103011 2784
GK mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 147.0 mmHg 7.0 18.52 vascular transducer tipped catheter 0.0 0 103018 2784
GK mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 123.0 mmHg 5.0 13.23 vascular transducer tipped catheter 0.0 0 103026 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 136.0 mmHg 13.0 34.39 vascular transducer tipped catheter 0.0 0 103028 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 6 undefined 120.0 mmHg 7.0 17.15 vascular transducer tipped catheter 0.0 0 103031 2784
GK mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 5 undefined 137.0 mmHg 3.0 6.71 vascular transducer tipped catheter 0.0 0 103033 2784
Crlj:WI heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 6 275.0 beats/min 8.0 19.6 vascular transducer tipped catheter 0.0 0 103051 2784
GK heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 279.0 beats/min 17.0 44.98 vascular transducer tipped catheter 0.0 0 103054 2784
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 23 26.3 ml/min 1.02 4.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20287 381
SS-Chr 11BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 -0.66 degrees C 0.42 1.26 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20375 381
SS-Chr 1BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 0.68 degrees C 0.24 0.75 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20378 381
FHH-Chr 11BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 5 -0.96 degrees C 0.65 1.44 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20383 381
SS-Chr 20BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 14 137.95 % 6.35 23.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53767 381
SS-Chr 19BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 104.08 % 12.79 36.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53775 381
SS-Chr 5BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 115.86 % 10.91 34.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53878 381
LEW/Crl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 1 105.31 % stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 53880 381
FHH-Chr 8BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 108.56 % 7.9 23.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53891 381
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 117.95 % 4.95 19.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53902 381
SS-Chr 14BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 126.5 % 3.92 12.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53918 381
SS-Chr 6BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 109.48 % 4.22 15.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53924 381
SS-Chr 17BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 110.8 % 5.67 17.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53932 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 116.12 % 3.88 14.51 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53940 381
FHH-Chr 6BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 104.6 % 4.87 12.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53973 381
LEW/Crl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 18 36.96 degrees C 0.19 0.79 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19991 381
LE/BluGill heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 11 7.35 % 3.79 12.56 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49034 461
F344/DuCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 12.81 % 5.12 15.35 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49038 461
SS-Chr 11BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 0.05 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19808 381
SS-Chr 4BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 0.03 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19814 381
SS-Chr 4BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19822 381
SS-Chr 18BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.67 degrees C 0.1 0.3 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18228 381
SS-Chr 16BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 8 37.56 degrees C 0.11 0.31 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18234 381
SHR/NCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.36 degrees C 0.12 0.39 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18239 381
FHH-Chr 4BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 34.05 ml/min 3.43 11.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20226 381
SS-Chr 10BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 28.6 ml/min 2.09 6.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20249 381
FHH-Chr 17BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 28.14 ml/min 2.76 8.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20257 381
FHH-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 24.95 ml/min 2.27 7.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20263 381
LEW/Crl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 18 -0.61 degrees C 0.16 0.67 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19155 381
SS-Chr 16BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 877.01 s 29.89 94.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48926 461
Crl:CD(SD) absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 -6.91 mmHg 1.15 3.05 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20984 381
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 20 152.74 % 5.48 24.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53741 381
FHH-Chr 12BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 56.49 mmHg 1.9 6.3 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20459 381
FHH-Chr 8BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 54.31 mmHg 2.77 6.79 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20475 381
SS-Chr 3BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 61.72 mmHg 1.84 4.51 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20481 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 38.46 ml/min 2.87 7.58 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20127 381
SS/JrHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 56.13 mmHg 1.56 4.41 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19558 381
SS-Chr 18BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 -0.12 degrees C 0.17 0.51 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19572 381
FHH/EurMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 -0.66 degrees C 0.13 0.38 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19574 381
BN/NHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 -0.8 degrees C 0.23 0.7 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19580 381
FHH-Chr 12BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 12 -6.89 mmHg 0.78 2.71 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19607 381
SS-Chr 9BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 11 -5.4 mmHg 0.48 1.61 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19613 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 23 0.28 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15312 381
FHH-Chr 16BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 120.0 % 7.38 22.15 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54036 381
SS-Chr 4BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 104.81 % 3.92 15.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54061 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 116.7 breaths/min 8.69 28.82 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15581 381
GH/OmrMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 152.48 breaths/min 5.93 16.77 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15583 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 52.46 ml/min 2.55 9.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18067 381
SS-Chr 16BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 54.73 ml/min 5.16 13.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18069 381
SS-Chr 16BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 59.5 ml/min 5.59 14.78 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18072 381
Crl:CD(SD) blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 7.51 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18094 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.42 ml 0.02 0.06 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14626 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 11 131.52 mmHg 2.55 8.47 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14661 381
BN/NHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 95.6 mmHg 4.17 11.04 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14669 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 139.86 breaths/min 1.92 5.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15374 381
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 5 114.82 mmHg 3.61 8.07 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14412 381
SS-Chr 16BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.51 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17607 381
BN/NHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 7.5 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17613 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 112.85 breaths/min 5.02 15.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17692 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 9 -8.56 mmHg 0.38 1.14 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17708 381
SS-Chr 11BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 35.99 ml/min 2.51 7.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18725 381
FHH-Chr 11BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 48.74 ml/min 4.02 11.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18736 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 28.92 ml/min 1.73 7.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18742 381
FHH-Chr XBN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 137.36 % 11.61 36.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13676 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 6.19 g/dl 0.1 0.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36952 401
FHH-Chr 20BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.51 g/dl 0.05 0.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36968 401
FHH-Chr 20BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 5.51 g/dl 0.06 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36971 401
SS-Chr 19BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.86 g/dl 0.04 0.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36982 401
SS-Chr 9BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 17 5.96 g/dl 0.1 0.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36996 401
SS-Chr 14BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 20 5.6 g/dl 0.11 0.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36998 401
SS-Chr 17BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 5.49 g/dl 0.11 0.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37004 401
SS/JrHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 4 0.3 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37065 401
FHH-Chr 8BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 59.4 mg/dl 2.12 6.7 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37098 401
SS-Chr 13BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 12 81.75 mg/dl 2.57 8.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37104 401
FHH-Chr 16BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 9 103.11 mg/dl 2.73 8.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37148 401
SS-Chr 3BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 6 84.67 mg/dl 3.35 8.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37158 401
SS/JrHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 96 84.18 mg/dl 1.02 10.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37164 401
SS-Chr 1BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 6 81.33 mg/dl 4.85 11.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37167 401
BN/NHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 20 62.0 mg/dl 1.05 4.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37175 401
SS-Chr 14BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 6 27.25 mmHg 0.48 1.17 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17218 381
SS-Chr 5BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 2 26.73 mmHg 1.43 2.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17234 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 11 27.88 mmHg 0.63 2.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17237 381
SS-Chr 3BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 6 29.25 mmHg 1.05 2.58 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17246 381
FHH-Chr 19BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 6 27.23 mmHg 0.83 2.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17248 381
FHH-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 8 32.34 mmHg 0.71 2.0 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17256 381
SS-Chr 4BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 7 28.14 mmHg 0.85 2.25 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17270 381
Crl:CD(SD) percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 %change=VE during7-9 min hypoxia/control during standard conditions 139.28 % 7.59 25.17 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17337 381
WKY/NCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 20 %change=VE during7-9 min hypoxia/control during standard conditions 126.16 % 4.99 22.31 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17340 381
FHH-Chr 10BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.2 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15226 381
FHH-Chr XBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.27 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15229 381
FHH-Chr 8BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.26 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15234 381
FHH-Chr 1BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 18 0.35 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15248 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 0.37 ml 0.02 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15250 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 118.83 breaths/min 6.66 23.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14784 381
FHH-Chr XBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 148.17 breaths/min 6.32 19.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14790 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 117.97 breaths/min 3.71 14.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14780 381
SS-Chr 6BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 7.52 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17031 381
SS-Chr 17BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 7.53 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17034 381
SS-Chr 7BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 7 7.52 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17036 381
FHH-Chr 16BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.5 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17047 381
SS-Chr 9BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 17 109.93 breaths/min 4.13 17.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18303 381
FHH-Chr 17BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 124.69 breaths/min 6.84 20.53 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18314 381
FHH-Chr 13BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 131.83 breaths/min 10.04 31.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18325 381
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 11 107.22 mmHg 5.67 18.81 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14359 381
SS-Chr 12BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 4 116.75 mmHg 11.49 22.98 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14373 381
SS-Chr XBN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 138.26 mmHg 9.24 24.45 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14376 381
FHH-Chr 18BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.49 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17064 381
SS-Chr 11BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.56 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17072 381
SS-Chr 19BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 7.49 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17083 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.54 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17089 381
Crl:CD(SD) minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 51.81 ml/min 4.42 15.93 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18964 381
FHH/EurMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 5 55.18 mmHg 0.83 1.86 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18973 381
GH/OmrMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 56.31 mmHg 3.29 8.71 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18975 381
Crl:CD(SD) mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 9 63.78 fl 0.56 1.67 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36287 401
Crl:CD(SD) mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 9 59.49 fl 0.37 1.1 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36289 401
WKY/NCrl mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 9 58.22 fl 0.68 2.05 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36292 401
SS-Chr 16BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 6 139.17 mmol/l 0.7 1.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36336 401
LE/BluGill hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 9 58.07 % 0.79 2.37 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36349 401
F344/DuCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 12 59.76 % 0.61 2.11 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36352 401
LEW/Crl mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 18.49 pg 0.1 0.29 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36355 401
SS-Chr 15BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 201.7 U/l 6.5 20.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36382 401
FHH/EurMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 %change=VE during 2-3 min hypoxia/control during standard conditions 172.87 % 8.4 29.11 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14145 381
FHH-Chr 12BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 11 119.18 mmHg 4.58 15.19 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14314 381
FHH-Chr 16BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 4 107.75 mmHg 13.03 26.06 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14317 381
SHR/NCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 15 147.31 mmHg 5.31 20.56 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14327 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.28 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14907 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.39 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14908 381
FHH-Chr XBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.29 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13919 381
FHH/EurMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 7 9.41 mg/dl 0.17 0.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37296 401
FHH-Chr 8BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 122.33 breaths/min 4.53 15.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14795 381
SS-Chr 13BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 123.48 breaths/min 6.22 19.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14801 381
SS-Chr 19BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 121.12 breaths/min 11.43 32.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14814 381
FHH-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.26 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13931 381
FHH-Chr YBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 0.27 ml 0.01 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13936 381
SS-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.32 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13944 381
SS-Chr 14BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.32 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13955 381
SS-Chr 17BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.31 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13971 381
SS-Chr 7BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.32 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13974 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 23 0.3 ml 0.01 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14002 381
SS-Chr XBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 0.26 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14004 381
WKY/NCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 0.32 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14007 381
Crl:CD(SD) tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.32 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14012 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 62.79 ml/min 3.82 14.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18648 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 47.39 ml/min 2.53 10.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18659 381
FHH-Chr 4BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 55.71 ml/min 6.0 21.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18678 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 49.67 ml/min 2.25 8.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18686 381
SS-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 48.77 ml/min 4.43 15.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18689 381
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 10 273.08 beats/min 29.68 93.86 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17548 381
SS-Chr 14BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 110.06 breaths/min 3.63 12.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14831 381
SS-Chr 7BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 116.66 breaths/min 7.76 24.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14845 381
SS-Chr YBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 19 121.43 breaths/min 4.49 19.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14861 381
SS-Chr XBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 109.33 breaths/min 4.14 14.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14864 381
FHH-Chr 4BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 %change=VE during 2-3 min hypoxia/control during standard conditions 146.38 % 10.59 36.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13698 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 %change=VE during 2-3 min hypoxia/control during standard conditions 148.43 % 6.67 24.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13704 381
SS-Chr 16BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 %change=VE during 2-3 min hypoxia/control during standard conditions 154.89 % 5.73 20.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13739 381
FHH-Chr 10BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.03 mg/dl 0.15 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36623 401
SS-Chr 12BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.45 mg/dl 0.08 0.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36645 401
SS-Chr 9BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 18 9.12 mg/dl 0.16 0.7 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36661 401
FHH-Chr 16BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 9 10.06 mg/dl 0.12 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36675 401
FHH-Chr 13BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.69 mg/dl 0.14 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36683 401
BN/NHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 17 8.76 mg/dl 0.1 0.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36703 401
FHH/EurMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 7 84.71 mg/dl 4.64 12.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36711 401
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 5 -4.67 mmHg 0.69 1.55 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19327 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 -6.79 mmHg 0.65 1.6 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19333 381
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 40.2 ml/min 2.09 8.09 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19435 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 -44.02 mmHg 3.33 8.15 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19492 381
FHH-Chr 1BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 -52.91 mmHg 4.32 11.43 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19512 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 115.62 breaths/min 4.48 17.35 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18146 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 30.22 mmHg 0.63 1.55 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18171 381
LE/BluGill minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 56.55 ml/min 2.59 9.32 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19725 381
SS-Chr 16BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 10 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19788 381
SS-Chr 13BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 0.07 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19799 381
FHH-Chr 12BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 30.85 % 5.02 17.38 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47068 461
FHH-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 51.44 % 4.07 12.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47085 461
FHH-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 52.01 % 4.08 12.25 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47087 461
FHH-Chr 4BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 43.5 % 3.5 10.51 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47095 461
FHH-Chr 13BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 39.88 % 2.24 7.09 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47136 461
SS-Chr 1BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 38.44 % 4.65 11.4 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47144 461
BN/NHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 23 post-ischemic value/pre-ischemic value x 100% 55.18 % 3.21 15.39 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47154 461
SS-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 5.28 mmHg 0.39 1.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47192 461
SS-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 16 5.4 mmHg 0.25 1.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47204 461
SS-Chr 19BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.34 mmHg 0.12 0.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47219 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 5.79 mmHg 0.15 0.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47221 461
FHH-Chr 1BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.18 mmHg 0.24 0.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47223 461
LEW/Crl time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 849.79 s 32.99 104.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48119 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 62.16 mmHg 3.13 8.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45054 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 52.57 mmHg 4.49 12.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45060 461
WKY/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 15.58 ml/min/g 0.62 1.85 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45081 461
Crl:CD(SD) arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 14.76 ml/min/g 0.5 1.58 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45083 461
WKY/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 14.76 ml/min/g 1.11 3.49 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45089 461
F344/DuCrl time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1011.89 s 25.81 81.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45104 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 8.02 IU/g 1.87 4.19 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45116 461
FHH-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 267.31 beats/min 62.35 187.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45156 461
SS-Chr 19BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 260.7 beats/min 48.91 129.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45168 461
GH/OmrMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 10.33 ml/min/g 0.78 1.91 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46287 461
SS-Chr 10BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 5.93 mmHg 0.16 0.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47237 461
SS-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 4.86 mmHg 0.41 1.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47252 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 12 0.23 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47424 461
SS-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 15 0.31 IU/g 0.04 0.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47428 461
SS-Chr 6BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.21 IU/g 0.04 0.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47430 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 12 0.18 IU/g 0.06 0.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47432 461
FHH-Chr 10BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 4 0.8 IU/g 0.27 0.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47443 461
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.2 IU/g 0.05 0.16 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47449 461
SS-Chr 14BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 94.28 % 4.85 20.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48331 461
GH/OmrMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 71.22 % 11.09 31.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48339 461
FHH-Chr 3BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 80.33 % 11.87 29.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48358 461
FHH-Chr 11BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 60.37 % 12.88 28.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48368 461
FHH-Chr 7BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 80.76 % 5.14 16.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48371 461
BN/NHsdMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 23 post-ischemic value/pre-ischemic value x 100% 86.83 % 2.21 10.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48373 461
FHH-Chr 19BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 207.52 beats/min 30.26 90.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45200 461
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 228.17 beats/min 8.63 24.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45203 461
SS-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 15 230.34 beats/min 28.03 108.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45205 461
FHH-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 149.2 beats/min 30.4 67.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45221 461
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 29.0 mmHg 9.15 22.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45242 461
FHH-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 23.41 mmHg 3.91 11.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45257 461
FHH-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 47.22 mmHg 8.01 25.34 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45261 461
SS-Chr 5BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 34.39 mmHg 3.29 9.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45265 461
SHR/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 56.32 mmHg 5.51 19.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45267 461
FHH-Chr 10BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 37.48 mmHg 5.81 16.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45269 461
FHH-Chr 8BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 45.52 mmHg 10.09 28.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45271 461
FHH-Chr 20BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 58.25 mmHg 7.17 21.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45276 461
FHH-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 48.66 mmHg 6.9 20.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45280 461
FHH-Chr 5BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 23.58 mmHg 2.09 5.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45300 461
FHH-Chr 14BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 22.9 mmHg 7.87 19.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45311 461
FHH-Chr 19BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 92.84 mmHg 5.56 17.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45785 461
SS-Chr YBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 24 139.37 mmHg 4.46 21.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45794 461
SS-Chr 1BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 97.56 mmHg 13.84 39.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45796 461
SS-Chr 1BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 102.8 mmHg 10.11 28.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45798 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 40.02 mmHg 8.66 32.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45321 461
FHH-Chr 19BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 51.35 mmHg 7.34 23.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45326 461
FHH-Chr 13BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 45.0 mmHg 9.34 26.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45328 461
SS-Chr 11BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 22 44.85 mmHg 3.96 18.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45334 461
GH/OmrMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 10.99 IU/g 0.94 2.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45371 461
GH/OmrMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 219.57 mmHg 18.35 48.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45375 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 141.43 mmHg 10.28 27.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45377 461
FHH/EurMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 5 1.94 g 0.15 0.34 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45384 461
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 12 11.57 ml/min/g 0.41 1.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46644 461
FHH-Chr 10BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 4 13.0 ml/min/g 1.49 2.98 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46646 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 12 12.7 ml/min/g 1.05 3.65 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46677 461
SS-Chr 9BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 11.6 ml/min/g 0.76 3.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46687 461
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 0.41 ml 0.03 0.07 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16032 381
FHH-Chr 14BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 6.5 g/kg 0.53 1.58 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45609 461
SS-Chr 17BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 5.43 g/kg 0.2 0.62 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45611 461
GH/OmrMcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 6.43 g/kg 0.32 1.01 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45615 461
SHR/NCrl heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 6.65 g/kg 0.23 0.74 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45622 461
FHH-Chr 20BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 6.93 g/kg 0.43 1.35 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45643 461
SS-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 11 11.58 ml/min/g 0.46 1.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46698 461
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 10.47 ml/min/g 0.81 2.29 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46716 461
FHH-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 10.49 ml/min/g 0.22 0.71 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46725 461
FHH-Chr 9BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 12.84 ml/min/g 1.67 5.29 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46733 461
FHH-Chr 20BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 4.32 ml/min/g 0.28 0.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44727 461
F344/DuCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 55.89 % 2.3 7.26 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47885 461
SS/JrHsdMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 8 1.27 g 0.06 0.17 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 45832 461
SS/JrHsdMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 481.04 s 111.83 316.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45840 461
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 172.75 mmHg 9.5 26.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45867 461
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 287.03 beats/min 8.89 25.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45869 461
SS-Chr 10BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 34.82 IU/g 2.37 6.71 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45961 461
FHH-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 7.1 IU/g 0.77 2.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45963 461
SS-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 18.62 IU/g 3.31 9.36 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45978 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 14 24.75 IU/g 3.07 11.5 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45980 461
FHH-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 23.98 IU/g 2.79 7.39 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45988 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 38 17.04 IU/g 1.18 7.26 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45990 461
SS-Chr XBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 20.17 IU/g 2.03 6.09 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45996 461
SS-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 15.96 IU/g 2.56 7.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45998 461
SS-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 12.57 IU/g 2.32 7.35 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46004 461
SS-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 18.39 IU/g 1.31 3.72 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46007 461
LEW/Crl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 8.74 ml/min/g 0.91 2.87 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46175 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 3 7.07 ml/min/g 0.32 0.55 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46183 461
SS-Chr 16BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 18 6.29 ml/min/g 0.88 3.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44775 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 20 7.85 ml/min/g 0.68 3.05 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44779 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 16 6.97 ml/min/g 1.32 5.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44789 461
SS-Chr 4BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 18 6.74 ml/min/g 0.39 1.68 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44792 461
BN/NHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 23 9.42 ml/min/g 0.62 2.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44796 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 5.28 ml/min/g 0.35 0.92 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 44901 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 3 34.51 IU/g 7.7 13.34 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46012 461
F344/DuCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.35 mmHg 0.1 0.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48009 461
FHH-Chr 16BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 20 6.51 ml/min/g 0.59 2.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44768 461
FHH/EurMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 7 3.83 x 1000 cells/ul 0.51 1.36 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41483 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 14 4.93 x 1000 cells/ul 0.47 1.75 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41489 401
FHH-Chr 12BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 11 4.4 x 1000 cells/ul 0.39 1.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41494 401
SHR/NCrl blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 18 3.5 x 1000 cells/ul 0.34 1.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41497 401
SS-Chr 3BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 11 60.83 ml/min/kg 8.03 26.62 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58060 526
SS-Chr XBN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 14 49.78 ml/min/kg 4.21 15.77 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58068 526
BN/NHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 28 49.29 ml/min/kg 3.1 16.42 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58077 526
SS/JrHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 7 0.07 mmHg-1 0.02 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58093 526
FHH-Chr 10BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.49 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58112 526
SS-Chr 15BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.35 null 0.01 0.04 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58117 526
FHH-Chr 18BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.49 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58123 526
FHH-Chr XBN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.37 degrees C 0.22 0.69 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16572 381
FHH-Chr 8BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 36.84 degrees C 0.08 0.24 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16577 381
SS-Chr 19BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 36.79 degrees C 0.13 0.38 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16594 381
SS-Chr 12BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 8 36.71 degrees C 0.56 1.59 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16597 381
LEW/Crl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 1 37.8 degrees C digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16605 381
Crl:CD(SD) absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 5 0.04 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16667 381
SS-Chr 10BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 64.4 U/l 3.09 9.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42799 401
FHH-Chr 15BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 104.63 U/l 7.35 20.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42809 401
FHH-Chr 9BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 6 102.0 U/l 5.32 13.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42851 401
FHH-Chr XBN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.31 mg/dl 0.01 0.04 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39572 401
FHH-Chr 18BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.23 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39586 401
SS-Chr 13BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 11 0.3 mg/dl 0.01 0.04 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39588 401
SS-Chr 10BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.29 mg/dl 0.01 0.03 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39605 401
SS-Chr 17BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.38 mg/dl 0.03 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39618 401
SS-Chr 7BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 11 0.27 mg/dl 0.03 0.1 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39621 401
FHH-Chr 18BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.55 x 1000 cells/ul 0.09 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39682 401
SS-Chr 20BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 33 0.4 x 1000 cells/ul 0.06 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39685 401
SS-Chr 19BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.24 x 1000 cells/ul 0.04 0.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39696 401
SS-Chr 6BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.21 x 1000 cells/ul 0.04 0.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39707 401
FHH-Chr 17BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 6 0.42 x 1000 cells/ul 0.03 0.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39720 401
FHH-Chr 13BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.22 x 1000 cells/ul 0.08 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39734 401
SS-Chr 4BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 26 0.45 x 1000 cells/ul 0.08 0.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39745 401
FHH-Chr 9BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 6 0.42 x 1000 cells/ul 0.17 0.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39750 401
FHH-Chr YBN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 9 5.88 x 1000 cells/ul 0.27 0.81 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41516 401
FHH-Chr 4BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 7 3.59 x 1000 cells/ul 0.44 1.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41521 401
SS-Chr 9BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 17 6.76 x 1000 cells/ul 0.28 1.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41537 401
FHH-Chr 13BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 4.06 x 1000 cells/ul 0.22 0.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41562 401
SS-Chr 4BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 29 4.87 x 1000 cells/ul 0.22 1.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41578 401
BN/NHsdMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 15 5.7 x 1000 cells/ul 0.53 2.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41581 401
SS-Chr YBN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 20 25.75 mmol/l 0.51 2.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38327 401
FHH-Chr 7BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 18.1 mmol/l 0.59 1.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38338 401
SS-Chr 12BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.4 null 0.02 0.07 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58134 526
FHH-Chr 5BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.53 null 0.07 0.2 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58148 526
FHH-Chr 1BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 0.41 null 0.04 0.15 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58128 526
FHH-Chr 4BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.52 null 0.04 0.12 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58131 526
LEW/Crl red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 10.83 x 10E6 cells/ul 0.2 0.55 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38150 401
SS/JrHsdMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 2 60.75 fl 0.35 0.5 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38164 401
FHH/EurMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 7 0.09 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38197 401
Crl:CD(SD) serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 9 141.33 mmol/l 0.53 1.58 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38238 401
FHH-Chr 12BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 12 21.92 mmol/l 0.87 3.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38246 401
FHH-Chr 12BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 11 24.09 mmol/l 0.67 2.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38252 401
SS-Chr 13BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 12 25.25 mmol/l 1.91 6.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38268 401
LE/BluGill blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 18.51 g/dl 0.23 0.68 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38404 401
WKY/NCrl blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 19.02 g/dl 0.41 1.22 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38406 401
SS/JrHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 4 103.75 mmol/l 1.49 2.99 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 38409 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 14 153.43 mg/dl 4.08 15.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38516 401
FHH-Chr 6BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.06 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41635 401
SS-Chr 20BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 26 0.03 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41649 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 11 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41671 401
SS-Chr 10BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41676 401
FHH-Chr 13BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.09 x 1000 cells/ul 0.02 0.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41706 401
SS-Chr 1BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 6 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41717 401
Hsd:SD total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 4 2.08 x 1000 cells/ul 0.47 0.94 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41733 401
SS-Chr 20BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 27 146.07 mg/dl 3.6 18.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38532 401
SS-Chr 9BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 18 173.0 mg/dl 6.24 26.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38567 401
Hsd:SD body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 8 212.4 g 4.8 13.6 whole body digital scale 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58436 526
Hsd:SD methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.72 null 0.06 0.16 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58439 526
Hsd:SD methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 20.29 ml/min/kg 1.74 4.27 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58466 526
SS-Chr 6BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 193.5 g 3.8 12.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49507 461
SS-Chr 10BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 162.5 g 2.7 8.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49509 461
GH/OmrMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 143.2 g 2.5 8.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49517 461
SS-Chr 17BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 142.0 g 2.5 7.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49519 461
SHR/NCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 136.9 g 3.5 11.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49524 461
FHH-Chr 10BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 12 91.2 g 6.9 23.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49526 461
FHH-Chr 13BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 147.1 g 5.4 17.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49540 461
FHH-Chr 20BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 148.7 g 7.2 22.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49545 461
FHH-Chr 4BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 135.2 g 6.0 18.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49563 461
SS-Chr 4BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 20 171.4 g 2.7 12.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49565 461
FHH-Chr 1BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 139.2 g 6.4 20.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49586 461
F344/DuCrl heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 46.5 mmHg 4.88 15.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49590 461
Hsd:SD heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 3 63.33 mmHg 11.57 20.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49592 461
FHH-Chr 10BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 7 1.08 x 1000 cells/ul 0.21 0.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43217 401
SS-Chr 13BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 12 0.56 x 1000 cells/ul 0.08 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43231 401
SS-Chr 9BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 15 0.89 x 1000 cells/ul 0.12 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43261 401
FHH-Chr 16BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 9 0.69 x 1000 cells/ul 0.05 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43275 401
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 104.47 % 3.93 14.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54549 381
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 102.66 % 4.05 15.68 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 54567 381
SS-Chr 16BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 131.99 % 9.59 21.44 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53538 381
SS-Chr 16BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 116.15 % 4.5 11.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53552 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 121.68 % 5.76 22.3 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53590 381
WKY/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 127.08 % 4.06 16.25 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53604 381
WKY/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 116.89 % 3.73 14.91 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53615 381
GH/OmrMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 18 146.72 mg/dl 5.7 24.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38579 401
SS-Chr 11BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 17 145.12 mg/dl 5.59 23.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38592 401
SS-Chr 1BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 6 134.5 mg/dl 10.67 26.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38598 401
SS-Chr 18BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 14 828.5 s 38.98 145.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49316 461
SS-Chr 14BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 19 852.26 s 22.54 98.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49335 461
SS-Chr 1BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 825.67 s 33.4 100.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49368 461
FHH-Chr 9BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 835.2 s 48.9 154.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49379 461
SS-Chr 15BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 31.79 g/dl 0.17 0.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39781 401
FHH-Chr 1BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 13 32.48 g/dl 0.27 0.99 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39792 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 31.96 g/dl 0.09 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39801 401
FHH-Chr 1BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 32.01 g/dl 0.12 0.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39803 401
LEW/Crl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 95.63 mmHg 3.84 11.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49279 461
FHH-Chr 2BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 950.88 s 32.21 91.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49291 461
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 115.73 % 5.36 18.56 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 54308 381
SS-Chr 17BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 122.37 % 7.37 23.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54373 381
SS-Chr 7BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 135.84 % 11.04 34.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54375 381
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 7 56.0 % 0.88 2.34 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38355 401
LEW/Crl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 16.64 IU/g 0.93 2.93 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49619 461
Hsd:SD percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 75.29 % 7.5 21.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49625 461
Hsd:SD percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 2 post-ischemic value/pre-ischemic value x 100% 88.39 % 1.7 2.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49660 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.23 IU/g 0.06 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 49677 461
SS-Chr 15BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 8 6.47 % 1.15 3.25 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49702 461
FHH-Chr 20BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 8 7.45 % 1.65 4.68 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49704 461
FHH-Chr 18BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 9 11.06 % 4.49 13.48 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49706 461
FHH-Chr 4BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 8.47 % 2.05 6.49 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49716 461
SS-Chr 2BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 5.99 % 1.93 6.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49725 461
SS-Chr 6BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 3.0 % 0.74 2.21 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49731 461
SS-Chr 17BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 10.86 % 2.74 8.66 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49740 461
FHH-Chr 17BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 17 12.84 % 2.61 10.76 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49744 461
SS/JrHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 9 1.08 x 1000 cells/ul 0.37 1.12 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43406 401
SS-Chr 16BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 7 142.0 U/l 52.52 138.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 43414 401
SS/JrHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 6 110.0 U/l 24.49 59.99 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 43416 401
FHH-Chr 12BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 12 1.21 g 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45396 461
FHH-Chr 10BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 0.41 g 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45398 461
FHH-Chr 8BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 1.01 g 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45410 461
SS-Chr 18BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 0.98 g 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45419 461
SS-Chr 19BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.84 g 0.05 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45427 461
FHH-Chr 1BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.85 g 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45431 461
SS-Chr 14BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 18 0.82 g 0.02 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45437 461
FHH-Chr 5BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.88 g 0.11 0.34 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45440 461
SS-Chr 9BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 18 0.94 g 0.04 0.17 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45442 461
FHH-Chr 16BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 20 0.88 g 0.03 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45448 461
FHH-Chr 3BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 6 0.67 g 0.07 0.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45458 461
SS-Chr 3BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.62 g 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45460 461
SS-Chr 10BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 4.91 g/kg 0.17 0.53 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45591 461
FHH-Chr 14BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 6.28 g/kg 0.43 1.28 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45593 461
FHH-Chr 15BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 40.89 mmHg 7.0 15.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46456 461
SS-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 48.95 mmHg 4.17 13.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46462 461
SS-Chr 17BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 51.83 mmHg 2.57 7.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46464 461
FHH-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 58.58 mmHg 9.9 22.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46470 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 89 56.0 mmHg 1.75 16.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46483 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 56.3 mmHg 4.75 15.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46532 461
SS-Chr 16BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 22 50.36 mmHg 3.67 17.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50051 461
SS-Chr 11BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 21 45.19 mmHg 4.03 18.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50058 461
SS-Chr YBN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 29 45.52 mmHg 2.58 13.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50062 461
SS-Chr 1BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 32.13 mmHg 5.03 14.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50064 461
Crl:CD(SD) body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 190.4 g 7.4 23.4 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50083 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 0.31 IU/g 0.04 0.09 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50091 461
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 89.13 mmHg 6.03 22.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49905 461
SS-Chr 10BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 101.64 mmHg 3.66 10.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49917 461
FHH-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 91.2 mmHg 8.63 21.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49923 461
SS-Chr 10BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 95.42 mmHg 8.39 25.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49928 461
SS-Chr 17BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 93.05 mmHg 3.76 11.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49930 461
FHH-Chr 16BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 20 93.17 mmHg 3.95 17.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49938 461
SS-Chr 16BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 22 98.16 mmHg 2.72 12.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49942 461
SS-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 89.04 mmHg 6.57 20.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49948 461
SS-Chr 1BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 85.94 mmHg 4.72 12.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49957 461
FHH-Chr 9BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 88.47 mmHg 9.51 28.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49963 461
FHH-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 95.33 mmHg 5.64 17.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49969 461
F344/DuCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 241.21 beats/min 9.9 31.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49980 461
FHH-Chr 2BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 25.6 mmHg 1.97 6.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49984 461
FHH-Chr 6BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 34.63 mmHg 2.05 5.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49986 461
FHH-Chr 12BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 12 43.25 mmHg 3.84 13.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49988 461
SS-Chr 20BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 23 55.13 mmHg 2.74 13.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49999 461
FHH/EurMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 8 0.49 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 58886 526
SS-Chr 19BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.18 mg/kg 0.26 0.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58926 526
SS-Chr 9BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.64 mg/kg 0.24 0.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58943 526
FHH-Chr 19BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 5.63 % 1.83 5.78 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49750 461
SS-Chr 16BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 22 21.35 % 3.08 14.42 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49752 461
SS-Chr 3BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 11.09 % 2.64 7.92 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49758 461
GH/OmrMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 7 52.86 mmHg 4.36 11.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 49795 461
F344/DuCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 143.7 mmHg 6.26 18.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49803 461
FHH-Chr 6BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 57.53 fl 0.31 1.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38733 401
FHH-Chr 2BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.13 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41860 401
FHH-Chr XBN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 7 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41868 401
SS-Chr 6BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 9 0.12 mg/dl 0.01 0.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41901 401
FHH-Chr 14BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41909 401
FHH-Chr 13BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58548 526
F344/DuCrl methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 13 0.3 null 0.03 0.11 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58580 526
LEW/Crl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 150.58 mmHg 5.99 18.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49807 461
SS-Chr 19BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1084.8 s 39.82 125.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50249 461
FHH-Chr 1BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1154.0 s 24.51 77.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50253 461
FHH-Chr 15BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 1192.75 s 30.33 85.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50255 461
FHH-Chr 5BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1150.4 s 22.18 70.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50257 461
FHH-Chr 3BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 1324.5 s 67.5 190.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50290 461
SS-Chr 1BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 943.5 s 52.1 147.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50294 461
FHH-Chr 7BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1261.7 s 43.13 136.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50303 461
Crl:CD(SD) absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 -0.63 degrees C 0.2 0.65 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19158 381
FHH-Chr 7BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 86.82 % 9.05 28.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48837 461
FHH-Chr 16BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 9 59.27 fl 0.23 0.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38796 401
SS-Chr 3BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 7 58.47 fl 0.54 1.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38801 401
FHH-Chr 2BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 56.98 fl 0.36 1.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38737 401
SS-Chr 4BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 29 1.9 g/dl 0.07 0.39 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40625 401
SS-Chr 20BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 103.75 mmol/l 1.21 3.41 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40658 401
Hsd:SD blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 4 1.52 x 1000 cells/ul 0.49 0.98 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 40664 401
Crl:CD(SD) blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 9 0.38 x 1000 cells/ul 0.09 0.26 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40693 401
FHH-Chr 10BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 72.25 U/l 8.11 22.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40707 401
SS-Chr 15BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 39.75 U/l 3.4 9.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40718 401
SS-Chr 13BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 12 43.25 U/l 1.55 5.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40721 401
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 268.88 beats/min 13.6 40.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47642 461
FHH/EurMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 66.8 % 5.74 15.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48504 461
SS-Chr 20BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 22 post-ischemic value/pre-ischemic value x 100% 27.17 % 4.24 19.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48529 461
SS-Chr 10BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 56.5 % 4.56 9.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48567 461
FHH-Chr 13BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 40.3 % 4.31 12.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48586 461
FHH-Chr 9BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 25.66 % 6.09 18.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48607 461
FHH-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 111.93 mmHg 2.53 5.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48609 461
FHH-Chr 6BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 115.77 mmHg 7.88 22.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48613 461
FHH-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 140.05 mmHg 11.43 32.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48615 461
FHH-Chr XBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 106.89 mmHg 8.02 22.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48624 461
SS-Chr 20BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 21 141.7 mmHg 4.29 19.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48626 461
FHH-Chr 20BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 122.94 mmHg 4.72 14.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48630 461
FHH-Chr 4BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 100.14 mmHg 8.24 24.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48642 461
SS/JrHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 9 1.42 g/kg 0.02 0.05 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58706 526
SS-Chr 13BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 11 0.4 null 0.01 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58740 526
SS-Chr 13BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 11 0.42 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58745 526
FHH-Chr 1BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 16 0.31 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58748 526
SS-Chr 19BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.44 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58753 526
SS-Chr 2BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.25 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58756 526
SS-Chr 2BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 48.8 U/l 3.92 12.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40737 401
SS-Chr 10BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 49.6 U/l 3.65 11.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40743 401
SS-Chr 9BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 16 137.0 mmHg 7.41 29.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48661 461
FHH-Chr 17BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 117.37 mmHg 4.73 14.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48670 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 75 124.69 mmHg 3.0 25.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48690 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 98.29 mmHg 6.85 18.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48724 461
SS-Chr 18BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 82.11 % 7.43 27.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48773 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 71.08 % 7.77 25.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48775 461
FHH-Chr 14BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 79.11 % 8.13 16.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48787 461
SS-Chr 14BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 105.23 % 7.65 33.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48792 461
F344/DuCrl blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 14 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40504 401
FHH-Chr 2BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.5 g/dl 0.07 0.2 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40537 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 2.16 g/dl 0.04 0.13 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40540 401
SS-Chr 5BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.66 g/dl 0.05 0.13 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40545 401
SS-Chr 20BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 34 2.33 g/dl 0.06 0.35 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40561 401
SS-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 25 0.36 IU/g 0.12 0.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47481 461
FHH-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.34 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47486 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 12 0.25 IU/g 0.04 0.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47494 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 19 0.73 IU/g 0.06 0.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47506 461
SS-Chr 15BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 212.14 beats/min 15.56 46.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47586 461
FHH-Chr 1BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 241.58 beats/min 8.76 27.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47608 461
SS-Chr 17BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 242.29 beats/min 8.23 24.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47629 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 238.5 g 4.9 15.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59048 526
FHH-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 12 193.3 g 3.2 11.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59053 526
FHH-Chr XBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 118.9 g 5.8 18.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59058 526
FHH-Chr 4BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 153.4 g 2.6 8.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59080 526
FHH-Chr 17BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 155.2 g 2.5 7.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59110 526
FHH-Chr 13BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 161.6 g 2.6 8.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59121 526
SS-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.39 IU/g 0.03 0.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47467 461
FHH-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.44 IU/g 0.06 0.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47469 461
SS-Chr 16BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 14 0.34 null 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58791 526
FHH-Chr 3BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.56 null 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58797 526
Crl:CD(SD) methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 8.59 ml/min/kg 0.74 2.34 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58838 526
FHH-Chr 1BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 9 55.3 % 0.61 1.84 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59283 526
SS/JrHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 20.56 pg 0.28 0.84 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37562 401
FHH-Chr 6BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 10.15 mg/dl 0.37 1.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37582 401
FHH-Chr 10BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 11.29 mg/dl 0.65 1.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37587 401
FHH-Chr XBN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 9.76 mg/dl 0.4 1.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37590 401
SS-Chr 15BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 11.4 mg/dl 0.51 1.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37598 401
FHH-Chr 1BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 15 8.84 mg/dl 0.38 1.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37609 401
SS-Chr 14BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 17 8.81 mg/dl 0.22 0.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37626 401
F344/DuCrl plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 17 0.24 mg/dl 0.01 0.05 automated plasma creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40805 401
SS/JrHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 9 24.22 mg/dl 1.09 3.27 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40808 401
FHH-Chr 12BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 12 21.25 mg/dl 0.66 2.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40813 401
SS/JrHsdMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 90 61.77 fl 0.17 1.63 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38812 401
FHH-Chr 9BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 6 56.12 fl 0.5 1.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38826 401
FHH-Chr 19BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 20.9 mmol/l 0.53 1.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42115 401
SS-Chr 3BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 6 20.17 mmol/l 1.11 2.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42123 401
SS-Chr 4BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 29 20.48 mmol/l 0.48 2.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42137 401
SS/JrHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 9 88.44 U/l 9.23 27.68 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42170 401
FHH-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 11 55.15 % 0.58 1.93 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59248 526
SS-Chr 15BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 56.86 % 0.74 2.1 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59261 526
FHH-Chr 4BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 7 48.36 % 1.24 3.27 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59275 526
SS-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 57.17 % 0.47 1.49 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59280 526
SS-Chr 10BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 0.65 mg/kg 0.05 0.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58946 526
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 51 3.06 mg/kg 0.29 2.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58969 526
FHH-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 5 1.2 mg/kg 0.37 0.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58980 526
FHH-Chr 2BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 11.56 ml/min/kg 0.76 2.29 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57590 526
SHR/NCrl methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 20 10.18 ml/min/kg 0.55 2.46 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57592 526
FHH-Chr XBN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 19.66 ml/min/kg 1.75 4.29 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57598 526
FHH-Chr 18BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 17.41 ml/min/kg 1.04 2.95 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57606 526
FHH-Chr 16BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 17.55 ml/min/kg 1.07 2.83 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57641 526
WKY/NCrl heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.51 null 0.03 0.11 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59966 526
SS-Chr 20BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 26 53.29 % 0.67 3.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38993 401
FHH-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 49.08 % 0.91 2.87 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39001 401
SS-Chr 9BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 17 57.21 % 0.41 1.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39025 401
SS-Chr 9BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 15 56.17 % 0.5 1.94 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39028 401
SS-Chr 15BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 25.38 mg/dl 1.6 4.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40832 401
FHH-Chr 18BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 21.2 mg/dl 1.11 3.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40838 401
FHH-Chr 1BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 9 19.89 mg/dl 1.18 3.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40854 401
SS-Chr 10BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 20.8 mg/dl 1.06 3.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40857 401
FHH-Chr 17BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 6 25.17 mg/dl 2.56 6.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40874 401
SS-Chr 11BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 17 23.65 mg/dl 1.41 5.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40890 401
SS/JrHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 94 22.36 mg/dl 0.38 3.64 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40895 401
FHH-Chr 11BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 9 24.33 mg/dl 1.26 3.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40901 401
FHH-Chr 9BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 7 26.57 mg/dl 1.53 4.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40909 401
FHH-Chr 6BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 6.71 x 1000 cells/ul 0.58 1.84 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40914 401
SS-Chr 4BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 29 5.73 x 1000 cells/ul 0.21 1.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41001 401
FHH/EurMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 7 5.4 g/dl 0.12 0.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42194 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 14 3.7 g/dl 0.09 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42219 401
FHH-Chr XBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 53.23 % 2.09 5.9 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38987 401
FHH-Chr 13BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 49.64 % 0.5 1.58 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39050 401
SS-Chr 11BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 17 52.75 % 1.12 4.6 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39053 401
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 90 57.79 % 0.32 2.99 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39058 401
FHH-Chr 9BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 6 49.02 % 3.55 8.69 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39067 401
BN/NHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 15 55.28 % 0.49 1.9 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39069 401
FHH-Chr 9BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 6 53.2 % 1.49 3.65 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39072 401
FHH-Chr 6BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 107.8 mmol/l 0.7 2.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39105 401
FHH-Chr 3BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.25 g/dl 0.1 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42287 401
FHH/EurMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 7 8.6 mg/dl 0.39 1.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42317 401
Hsd:SD serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 16 54.13 U/l 5.89 23.57 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42342 401
Hsd:SD serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 18 44.11 U/l 3.56 15.12 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42344 401
Crl:CD(SD) serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 9 162.67 U/l 11.46 34.38 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42350 401
FHH-Chr 2BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.17 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59534 526
SS-Chr 13BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.16 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59559 526
FHH-Chr 9BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 13.46 ml/min/kg 1.39 3.42 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57679 526
F344/DuCrl calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 13 0.16 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57689 526
SS-Chr 7BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 12 113.58 mmol/l 0.45 1.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39167 401
FHH/EurMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 18 110.11 mmol/l 0.59 2.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39169 401
SS-Chr YBN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 20 107.95 mmol/l 0.47 2.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39183 401
SS/JrHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 107.9 mmol/l 0.6 1.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39189 401
FHH-Chr 10BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 7 8.94 x 10E6 cells/ul 0.18 0.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39230 401
FHH-Chr 1BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 13 9.8 x 10E6 cells/ul 0.08 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39252 401
Hsd:SD calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.1 mmHg x min x kg x ml-1 0.01 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57774 526
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 7 57.83 % 0.47 1.24 microhematocrit tube assay with visual assessment 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57777 526
FHH-Chr 8BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 28.92 ml/min/kg 0.93 2.94 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57801 526
FHH-Chr 18BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 30.02 ml/min/kg 1.35 4.26 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57810 526
LE/BluGill serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.73 mg/dl 0.12 0.38 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42529 401
FHH-Chr 8BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 18.56 pg 0.07 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42546 401
SS-Chr 13BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 12 145.33 mmol/l 0.73 2.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39395 401
FHH-Chr 18BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 142.8 mmol/l 0.79 2.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39398 401
FHH-Chr 4BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 7 141.71 mmol/l 0.52 1.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39406 401
SS-Chr 14BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 17 142.76 mmol/l 0.45 1.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39420 401
FHH-Chr 16BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 9 142.67 mmol/l 0.47 1.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39431 401
FHH-Chr 17BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 6 144.5 mmol/l 0.56 1.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39436 401
FHH-Chr 16BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 9 143.11 mmol/l 0.42 1.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39439 401
LE/BluGill serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 9 15.22 mg/dl 1.14 3.42 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39516 401
SS-Chr 7BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 17.51 g/dl 0.18 0.63 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38018 401
SS-Chr 15BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 7 4.83 mmol/l 0.26 0.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38070 401
FHH-Chr 1BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 9 4.7 mmol/l 0.15 0.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38092 401
SS-Chr 9BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 13 5.03 mmol/l 0.13 0.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38100 401
WKY/NCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 11 26.44 mmHg 0.64 2.12 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16362 381
FHH-Chr 20BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 20.07 pg 1.32 4.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42551 401
SS-Chr 18BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 19.5 pg 0.07 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42562 401
FHH-Chr 1BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 18.62 pg 0.15 0.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42571 401
FHH-Chr 20BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 20.85 g/dl 3.68 11.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37974 401
SS-Chr 19BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 17.15 g/dl 0.15 0.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37990 401
FHH/EurMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 64 1.54 g/kg 0.01 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59720 526
SS-Chr 4BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 22 1.21 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59728 526
Hsd:SD methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.87 null 0.06 0.16 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59742 526
GH/OmrMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 16 38.29 ml/min/kg 4.16 16.63 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58043 526
SS-Chr 16BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 35.21 ml/min/kg 2.77 7.85 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58054 526
Crlj:WI heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 415.0 beats/min 10.0 26.46 vascular transducer tipped catheter 0.0 0 103036 2784
Crlj:WI heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 287.0 beats/min 7.0 18.52 vascular transducer tipped catheter 0.0 0 103048 2784
BN/NHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 27 27.59 ml/min/kg 2.07 10.77 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57879 526
FHH-Chr 7BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 17.01 ml/min/kg 1.19 3.76 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57882 526
SS-Chr 15BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 143.47 breaths/min 9.63 37.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14797 381
FHH-Chr 8BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 133.5 breaths/min 4.9 14.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14799 381
FHH-Chr 4BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 146.23 breaths/min 8.37 30.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14810 381
SS-Chr 19BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 148.22 breaths/min 18.63 55.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14816 381
SS-Chr 6BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 123.58 breaths/min 5.23 18.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14833 381
FHH-Chr 16BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 142.49 breaths/min 9.58 35.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14838 381
SS-Chr 7BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 127.82 breaths/min 9.4 28.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14840 381
SS-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 110.93 breaths/min 8.36 28.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14851 381
SS-Chr 1BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 150.2 breaths/min 6.76 21.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14865 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.31 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14906 381
SS-Chr 16BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 0.44 ml 0.04 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14904 381
SS-Chr 5BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 122.56 breaths/min 6.84 21.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14789 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 121.05 mmHg 3.21 9.64 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14304 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 124.43 mmHg 3.67 10.39 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14309 381
SS-Chr 10BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 9 110.5 mmHg 2.9 8.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14315 381
SS-Chr 20BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 15 109.28 mmHg 5.62 21.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14331 381
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 12 112.88 mmHg 3.68 12.76 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14334 381
FHH-Chr 13BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 126.14 mmHg 3.59 10.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14344 381
FHH-Chr 18BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 10 127.52 mmHg 2.78 8.79 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14349 381
SS-Chr 11BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 127.9 mmHg 8.01 21.21 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14350 381
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 13 112.35 mmHg 5.55 20.03 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14355 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 0.42 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13644 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.41 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13645 381
FHH-Chr 12BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 %change=VE during 2-3 min hypoxia/control during standard conditions 134.35 % 5.92 25.78 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13665 381
SS/JrHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 7 -0.13 degrees C 0.12 0.31 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14136 381
FHH/EurMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 156.95 % 10.95 36.31 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14141 381
SS-Chr 16BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 %change=VE during 2-3 min hypoxia/control during standard conditions 160.24 % 4.24 9.47 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14144 381
SS/JrHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 %change=VE during 2-3 min hypoxia/control during standard conditions 143.64 % 6.6 17.46 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14146 381
FHH/EurMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 7.54 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20118 381
SS-Chr 16BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 6 35.76 ml/min 2.87 7.03 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20123 381
SS-Chr 16BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 38.89 ml/min 4.04 9.04 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20125 381
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 110.13 % 7.22 28.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54003 381
LE/BluGill body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 37.53 degrees C 0.12 0.43 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19999 381
FHH/EurMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 10 0.06 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19787 381
FHH-Chr 13BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.06 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19795 381
FHH-Chr 18BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 0.03 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19800 381
SS-Chr YBN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 13 0.05 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19807 381
FHH-Chr 1BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 9 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19812 381
SS-Chr 12BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19820 381
SS-Chr 12BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 3 0.05 null 0.0 0.0 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19826 381
Hsd:SD absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 12 0.07 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20697 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 45.77 ml/min 2.25 8.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20699 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 59.1 ml/min 5.55 16.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20705 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 45.35 ml/min 2.66 8.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20709 381
LE/BluGill minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 50.6 ml/min 3.49 11.03 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19721 381
FHH-Chr 8BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19784 381
FHH-Chr 6BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 125.09 % 11.58 30.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53740 381
SS-Chr 5BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 115.2 % 8.47 25.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53749 381
SS-Chr 13BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 120.16 % 8.49 25.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53768 381
SS-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 123.34 % 8.64 28.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53776 381
FHH-Chr 5BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 134.72 % 13.72 43.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53784 381
SS-Chr 7BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 136.2 % 10.9 32.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53798 381
SS-Chr 17BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 116.42 % 6.71 21.23 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53800 381
FHH-Chr 17BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 117.43 % 6.05 18.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53801 381
SS-Chr 7BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 134.22 % 10.56 33.39 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53802 381
FHH-Chr 16BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 121.57 % 6.77 20.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53803 381
FHH-Chr 19BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 14 126.13 % 8.47 31.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53805 381
FHH-Chr 19BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 130.66 % 6.34 23.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53810 381
SS-Chr YBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 19 125.33 % 4.4 19.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53818 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 113.53 % 8.09 28.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53824 381
FHH-Chr 7BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 110.9 % 6.17 17.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53834 381
GH/OmrMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 6 119.01 % 6.94 17.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53884 381
FHH-Chr 8BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 103.88 % 9.22 30.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53887 381
SS-Chr 15BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 105.08 % 2.85 11.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53889 381
SS-Chr 15BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 111.36 % 6.23 19.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53890 381
FHH-Chr 4BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 110.95 % 5.31 18.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53906 381
SS-Chr 10BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 110.77 % 4.59 15.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53915 381
FHH-Chr 19BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 97.87 % 3.95 14.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53937 381
SS-Chr YBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 114.04 % 3.14 13.67 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53950 381
FHH-Chr 11BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 104.27 % 6.25 17.67 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53958 381
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 132.93 % 5.74 22.25 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53967 381
SS-Chr 5BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 105.46 % 5.47 16.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53982 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 116.27 % 4.95 19.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53983 381
GH/OmrMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 6 105.3 % 7.41 18.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53985 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 23 109.62 % 4.44 21.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53996 381
FHH-Chr 20BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 104.26 % 6.56 18.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53997 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 106.19 % 3.96 16.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53998 381
LEW/Crl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 12 54.14 mmHg 1.75 6.05 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17012 381
LE/BluGill partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 50.03 mmHg 1.94 4.75 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17015 381
Hsd:SD partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 12 27.16 mmHg 0.72 2.48 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17017 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 49 133.43 breaths/min 3.84 26.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18329 381
Hsd:SD percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 %change=VE during7-9 min hypoxia/control during standard conditions 141.14 % 5.99 23.18 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17018 381
SS-Chr 10BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.52 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17021 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 10 7.53 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17022 381
SS-Chr 9BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 7.51 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17026 381
SS-Chr 14BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.51 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17029 381
SS-Chr 9BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 12 7.54 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17030 381
FHH-Chr 16BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 4 7.51 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17035 381
GH/OmrMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 3 7.51 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17037 381
SS-Chr 7BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 7.53 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17044 381
FHH-Chr 19BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 7.49 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17056 381
SS-Chr 16BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 9 7.49 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17057 381
SS-Chr 6BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 123.95 breaths/min 6.18 22.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18304 381
SS-Chr 17BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 118.36 breaths/min 8.8 30.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18308 381
GH/OmrMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 6 118.06 breaths/min 10.4 25.47 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18315 381
SS-Chr 16BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 127.88 breaths/min 5.37 20.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18321 381
SS-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 111.21 breaths/min 5.04 16.71 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18327 381
FHH-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 32.04 ml/min 3.04 9.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18727 381
SS-Chr XBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 27.2 ml/min 2.83 9.81 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18732 381
FHH-Chr 11BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 45.97 ml/min 3.37 10.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18737 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 8 413.33 beats/min 15.97 45.17 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18754 381
GH/OmrMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 463.94 beats/min 7.82 20.68 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18757 381
SS-Chr 16BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 4 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18786 381
FHH/EurMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18789 381
SS-Chr 20BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 27 81.04 mg/dl 2.0 10.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37099 401
SS-Chr 20BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 34 79.53 mg/dl 1.87 10.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37108 401
SS-Chr 18BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 78.4 mg/dl 3.29 10.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37111 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 9 84.33 mg/dl 1.22 3.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37116 401
SS-Chr 12BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 92.88 mg/dl 3.32 9.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37118 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 11 76.09 mg/dl 2.16 7.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37121 401
SS-Chr 14BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 17 79.06 mg/dl 1.68 6.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37129 401
FHH-Chr 14BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 68.25 mg/dl 4.17 11.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37138 401
GH/OmrMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 16 81.88 mg/dl 2.52 10.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37141 401
FHH-Chr 17BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 6 67.17 mg/dl 1.85 4.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37143 401
GH/OmrMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 18 78.89 mg/dl 2.0 8.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37146 401
SS-Chr 16BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 16 71.69 mg/dl 2.33 9.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37152 401
SS-Chr 1BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 6 79.0 mg/dl 1.88 4.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37165 401
SS-Chr XBN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 11 80.27 mg/dl 2.86 9.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37166 401
FHH-Chr 9BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 7 70.71 mg/dl 5.09 13.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37173 401
FHH-Chr 11BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 129.92 breaths/min 8.01 24.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18340 381
FHH-Chr 7BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 117.68 breaths/min 10.83 35.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18343 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 23 110.37 breaths/min 5.06 24.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18344 381
SS-Chr XBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 14 134.86 breaths/min 13.32 49.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18346 381
FHH/EurMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 %change=VE during7-9 min hypoxia/control during standard conditions 156.96 % 15.53 51.5 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18369 381
FHH-Chr 19BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 381.3 U/l 24.25 76.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36432 401
SS-Chr 16BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 16 130.88 U/l 8.82 35.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36434 401
FHH-Chr 13BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 309.5 U/l 11.95 37.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36438 401
SS-Chr XBN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 313.6 U/l 11.57 36.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36459 401
FHH-Chr 9BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 7 554.29 U/l 23.97 63.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36460 401
LEW/Crl serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 82.7 mg/dl 5.25 16.61 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36463 401
FHH-Chr 12BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 12 5.93 g/dl 0.04 0.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36947 401
FHH-Chr 6BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.45 g/dl 0.06 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36950 401
SHR/NCrl serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 20 6.14 g/dl 0.05 0.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36956 401
FHH-Chr 10BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 4.95 g/dl 0.06 0.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36961 401
FHH-Chr 18BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.28 g/dl 0.08 0.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36970 401
FHH-Chr 18BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 4.98 g/dl 0.09 0.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36972 401
SS-Chr 16BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 16 6.07 g/dl 0.05 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37017 401
FHH-Chr 19BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 5.11 g/dl 0.08 0.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37019 401
SS/JrHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 5.88 g/dl 0.04 0.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37034 401
FHH-Chr 11BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 9 4.81 g/dl 0.08 0.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37035 401
BN/NHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 17 5.38 g/dl 0.1 0.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37041 401
SS-Chr XBN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.14 g/dl 0.07 0.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37042 401
FHH/EurMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 7 0.23 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37066 401
SS-Chr 16BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 6 0.23 mg/dl 0.03 0.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37067 401
FHH/EurMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 7 0.24 mg/dl 0.03 0.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37069 401
SS/JrHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 2 20.05 pg 0.65 0.92 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 37071 401
SS-Chr 16BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 20.16 pg 0.23 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 37074 401
FHH/EurMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 7 136.29 mmol/l 0.78 2.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36335 401
FHH-Chr 6BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 363.0 U/l 8.42 26.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36367 401
FHH-Chr 10BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 453.0 U/l 33.34 94.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36378 401
SS-Chr 15BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 142.25 U/l 15.3 43.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36383 401
FHH-Chr 18BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 333.1 U/l 12.96 41.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36389 401
SS-Chr 19BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 204.3 U/l 5.44 17.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36399 401
FHH-Chr 14BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 394.63 U/l 23.83 67.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36410 401
SS-Chr 9BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 17 293.12 U/l 11.43 47.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36413 401
SS-Chr 6BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 207.38 U/l 9.83 27.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36417 401
FHH-Chr 15BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 348.13 U/l 12.3 34.8 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36418 401
FHH-Chr 17BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 6 397.0 U/l 34.66 84.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36425 401
FHH-Chr 17BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 6 273.5 U/l 9.04 22.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36427 401
FHH/EurMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 57.47 mmHg 5.33 9.23 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18977 381
Hsd:SD absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 12 -8.11 mmHg 1.01 3.51 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 18818 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.42 ml 0.02 0.07 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14627 381
SS-Chr 16BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 6 0.3 ml 0.02 0.05 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14628 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 0.37 ml 0.01 0.02 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14632 381
SS-Chr 18BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 6 128.36 mmHg 3.37 8.24 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14660 381
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 109.62 mmHg 6.18 16.36 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14663 381
FHH-Chr 15BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.29 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15261 381
FHH-Chr 5BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.27 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15263 381
SS-Chr 9BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 0.33 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15271 381
FHH-Chr 14BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.21 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15275 381
SS-Chr 17BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.28 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15281 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 0.39 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15306 381
FHH-Chr 11BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.34 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15308 381
FHH-Chr 9BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.2 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15310 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 0.23 ml 0.01 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15313 381
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 124.46 breaths/min 7.44 28.81 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15506 381
FHH/EurMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 134.35 mmHg 4.77 13.5 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14411 381
FHH-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 0.23 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15218 381
FHH-Chr XBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.23 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15233 381
FHH-Chr 8BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.33 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15238 381
FHH-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.25 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15241 381
FHH-Chr 4BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 0.31 ml 0.03 0.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15249 381
Crl:CD(SD) percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 101.48 % 3.3 10.95 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54191 381
F344/DuCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 110.67 % 3.4 14.41 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54194 381
WKY/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 20 100.69 % 3.04 13.61 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54195 381
LE/BluGill percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 98.04 % 8.11 25.64 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54196 381
WKY/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 114.92 % 5.05 20.18 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54200 381
FHH-Chr 7BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 119.0 % 5.48 15.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54067 381
FHH-Chr 7BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 2 31.88 mmHg 1.58 2.23 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17287 381
Hsd:SD partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 7 48.46 mmHg 1.59 4.2 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 17311 381
LE/BluGill percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypoxia/control during standard conditions 139.08 % 9.71 30.72 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17338 381
SHR/NCrl percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 20 %change=VE during 2-3 min hypoxia/control during standard conditions 156.99 % 8.63 38.59 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13674 381
FHH-Chr 20BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 143.06 % 12.34 37.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13686 381
SS-Chr 18BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 %change=VE during 2-3 min hypoxia/control during standard conditions 143.26 % 6.26 25.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13694 381
FHH-Chr 4BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 %change=VE during 2-3 min hypoxia/control during standard conditions 159.33 % 11.26 40.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13696 381
SS-Chr 12BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 %change=VE during 2-3 min hypoxia/control during standard conditions 133.86 % 10.6 29.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13705 381
SS-Chr 15BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.29 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13926 381
SS-Chr 13BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.34 ml 0.05 0.15 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13930 381
SS-Chr 13BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.34 ml 0.05 0.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13935 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 0.39 ml 0.03 0.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13940 381
FHH-Chr 14BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.21 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13954 381
FHH-Chr 16BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.36 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13975 381
FHH-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.22 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13978 381
SS-Chr 11BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.31 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13986 381
SS-Chr 4BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.35 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13995 381
FHH-Chr 9BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.22 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14005 381
FHH-Chr 7BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.2 ml 0.04 0.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14006 381
LE/BluGill tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.31 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14013 381
LEW/Crl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 20 0.35 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14014 381
SS/JrHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 %change=VE during 2-3 min hypoxia/control during standard conditions 169.75 % 7.65 28.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14031 381
FHH/EurMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 131.09 % 6.07 19.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14032 381
SS-Chr 18BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 %change=VE during 2-3 min hypoxia/control during standard conditions 151.65 % 13.31 35.23 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14035 381
WKY/NCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 14 110.54 mmHg 7.28 27.25 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13875 381
Crl:CD(SD) mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 9 109.25 mmHg 8.69 26.06 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13880 381
LE/BluGill mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 9 94.47 mmHg 7.0 21.0 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13881 381
F344/DuCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 11 113.26 mmHg 6.39 21.2 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13884 381
LE/BluGill mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 109.87 mmHg 6.68 20.03 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13885 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.49 ml 0.02 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13909 381
FHH-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.23 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13910 381
FHH-Chr 6BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.32 ml 0.03 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13911 381
SS-Chr 5BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.38 ml 0.04 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13921 381
SS-Chr 12BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 5 119.54 mmHg 16.45 36.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14366 381
SS-Chr 19BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 1 119.41 mmHg vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14369 381
SS-Chr 18BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 7.52 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17077 381
SS/JrHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 7.52 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17079 381
FHH-Chr 11BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 2 7.5 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17081 381
SS-Chr 19BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 1 7.49 null automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17087 381
SS-Chr 12BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 3 7.55 null 0.03 0.05 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17090 381
BN/NHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.45 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17092 381
FHH-Chr 1BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.48 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17095 381
LEW/Crl percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 1 %change=VE during 2-3 min hypoxia/control during standard conditions 131.04 % stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13713 381
SS-Chr 6BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 %change=VE during 2-3 min hypoxia/control during standard conditions 134.99 % 5.92 24.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13714 381
SS-Chr 10BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 173.67 % 8.59 27.15 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13721 381
FHH-Chr 17BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 125.79 % 8.32 24.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13729 381
SS/JrHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 %change=VE during 2-3 min hypoxia/control during standard conditions 148.41 % 7.07 24.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13753 381
FHH-Chr 11BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 %change=VE during 2-3 min hypoxia/control during standard conditions 139.68 % 12.64 35.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13754 381
FHH-Chr 9BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 136.05 % 10.12 30.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13762 381
F344/NHsd heart right ventricle wet weight controlled air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 heart right ventricle mass male 105 days 23 median 0.21 g post excision weight measurement 0 11567 102
SS-Chr 6BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 11 27.05 mmHg 0.86 2.84 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17225 381
SS-Chr 7BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 7 29.19 mmHg 0.72 1.92 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17230 381
SS-Chr 15BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 2 26.1 mmHg 4.4 6.22 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17247 381
FHH-Chr 1BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 11 27.65 mmHg 0.67 2.22 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17268 381
SS-Chr 18BN/Mcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 %change=VE during7-9 min hypoxia/control during standard conditions 139.64 % 12.52 33.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17917 381
BN/NHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 %change=VE during7-9 min hypoxia/control during standard conditions 123.13 % 6.51 18.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17921 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 10 -47.62 mmHg 2.17 6.85 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17935 381
SHR/NCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 -54.34 mmHg 3.56 8.72 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17938 381
BN/NHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 -51.1 mmHg 6.77 11.73 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17942 381
LEW/Crl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 123.2 breaths/min 4.35 18.45 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17557 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 65.09 ml/min 5.58 16.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18073 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 48.3 ml/min 3.95 12.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18076 381
LE/BluGill blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.48 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18095 381
LEW/Crl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 12 7.51 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18096 381
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 9 420.82 beats/min 24.13 72.4 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18102 381
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 6 449.47 beats/min 14.97 36.66 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18109 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 9 430.66 beats/min 12.88 38.63 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18110 381
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 4 366.99 beats/min 23.28 46.55 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18111 381
Hsd:SD absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 18 -0.47 degrees C 0.26 1.12 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20671 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 115.28 breaths/min 6.83 18.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17687 381
SS-Chr 16BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 125.02 breaths/min 10.09 26.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17688 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 10 -8.35 mmHg 0.56 1.77 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17707 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 -8.2 mmHg 1.55 3.8 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17710 381
SS/JrHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 15 37.6 degrees C 0.17 0.64 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17718 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 9 -6.56 mmHg 0.87 2.61 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19657 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 47 -6.23 mmHg 0.34 2.34 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19658 381
FHH-Chr 4BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 2 -8.85 mmHg 1.95 2.76 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19664 381
LEW/Crl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 10 -50.58 mmHg 3.12 9.86 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20692 381
SS-Chr 16BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 55.81 mmHg 1.45 4.11 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19551 381
BN/NHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 50.89 mmHg 1.79 4.72 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19557 381
SHR/NCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 -0.93 degrees C 0.24 0.73 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19576 381
SS-Chr 16BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 8 -0.34 degrees C 0.16 0.44 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19578 381
BN/NHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 8 -1.2 degrees C 0.27 0.76 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19581 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 -6.09 mmHg 0.99 2.43 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19625 381
FHH-Chr 17BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 -7.35 mmHg 0.79 2.23 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19627 381
SS-Chr 5BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 2 -7.1 mmHg 0.7 0.99 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19630 381
SS-Chr 20BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 9 -6.49 mmHg 1.0 3.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19633 381
FHH-Chr 18BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.48 mg/dl 0.14 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36632 401
SS-Chr 20BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 34 9.34 mg/dl 0.07 0.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36635 401
SS-Chr 19BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.71 mg/dl 0.1 0.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36644 401
FHH-Chr 14BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.24 mg/dl 0.16 0.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36655 401
SS-Chr 6BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 9 9.37 mg/dl 0.17 0.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36657 401
SS-Chr 14BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 20 9.24 mg/dl 0.11 0.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36660 401
FHH-Chr 15BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.1 mg/dl 0.29 0.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36663 401
FHH/EurMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 18 9.04 mg/dl 0.09 0.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36676 401
SS-Chr 16BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 16 8.76 mg/dl 0.06 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36679 401
SS-Chr 3BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 6 9.48 mg/dl 0.27 0.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36685 401
FHH/EurMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 50 9.28 mg/dl 0.08 0.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36687 401
SS/JrHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 94 9.23 mg/dl 0.06 0.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36691 401
SS/JrHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 7 121.86 mg/dl 12.45 32.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36712 401
Hsd:SD serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 3 105.0 U/l 14.43 25.0 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36726 401
SS/JrHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 8.99 mg/dl 0.09 0.3 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36732 401
SS-Chr 20BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 6.58 g/dl 0.15 0.42 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37409 401
LEW/Crl serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 9 80.11 U/l 8.84 26.53 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37423 401
Hsd:SD mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 4 22.58 pg 0.94 1.88 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36569 401
SS-Chr 20BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 142.13 mmol/l 1.06 3.0 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36594 401
Hsd:SD serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 18 142.56 mmol/l 0.93 3.96 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36595 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 14 9.56 mg/dl 0.1 0.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36610 401
FHH-Chr 12BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 11 9.71 mg/dl 0.1 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36615 401
SHR/NCrl serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 17 9.03 mg/dl 0.1 0.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36621 401
FHH-Chr XBN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 7 9.19 mg/dl 0.27 0.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36624 401
SS-Chr 15BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.36 mg/dl 0.09 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36627 401
SS-Chr 16BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 6 9.42 mg/dl 0.11 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37294 401
FHH-Chr 6BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 43.56 ml/min 5.6 18.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18650 381
SS-Chr 5BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 46.63 ml/min 3.67 11.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18660 381
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 46.84 ml/min 4.66 19.78 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18679 381
SS-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 35.35 ml/min 3.28 11.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18685 381
SS-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 30.97 ml/min 3.68 10.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18687 381
LEW/Crl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 1 40.78 ml/min stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18695 381
FHH-Chr 5BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 51.36 ml/min 3.04 9.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18698 381
SS-Chr 10BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 32.93 ml/min 1.74 5.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18703 381
SS-Chr 17BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 46.63 ml/min 2.98 10.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18705 381
GH/OmrMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 6 51.01 ml/min 8.13 19.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18712 381
FHH-Chr 16BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 52.03 ml/min 3.38 10.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18714 381
SS-Chr 10BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 363.66 beats/min 10.65 31.94 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17476 381
FHH-Chr 6BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 2 296.33 beats/min 106.07 150.01 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17478 381
SS-Chr 6BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 13 418.29 beats/min 10.03 36.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17480 381
SS-Chr 9BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 8 423.86 beats/min 17.23 48.72 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17481 381
SS-Chr 14BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 396.78 beats/min 5.64 16.93 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17484 381
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 11 411.34 beats/min 11.45 37.98 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17487 381
FHH-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 4 401.26 beats/min 38.1 76.2 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17490 381
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 402.69 beats/min 19.15 50.67 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17495 381
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 15 427.79 beats/min 11.17 43.27 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17500 381
FHH-Chr 19BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 411.84 beats/min 36.75 97.23 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17511 381
FHH-Chr 20BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 368.52 beats/min 21.37 56.55 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17520 381
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 10 412.88 beats/min 24.38 77.08 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17544 381
SS-Chr XBN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 412.26 beats/min 10.5 27.77 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17549 381
Crl:CD(SD) heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 9.36 % 4.43 14.02 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49030 461
Crl:CD(SD) heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 6.65 % 3.61 11.4 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49032 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 43.15 ml/min 2.38 8.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20198 381
FHH-Chr 15BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 38.87 ml/min 2.95 9.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20236 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 43.57 ml/min 2.34 9.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20205 381
SS-Chr 20BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 41.27 ml/min 1.71 7.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20210 381
SS-Chr 19BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 46.2 ml/min 8.98 26.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20230 381
SS-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 44.29 ml/min 2.89 10.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20235 381
SS-Chr 6BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 38.62 ml/min 2.08 8.59 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20242 381
FHH-Chr 15BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 37.87 ml/min 2.92 8.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20248 381
FHH-Chr 14BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 30.53 ml/min 1.58 5.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20250 381
SS-Chr 17BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 44.97 ml/min 3.29 11.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20251 381
GH/OmrMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 6 46.6 ml/min 8.6 21.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20258 381
SS-Chr 16BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 36.67 ml/min 1.61 6.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20264 381
SS-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 30.86 ml/min 2.29 7.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20270 381
SS-Chr 1BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 43.13 ml/min 1.78 5.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20277 381
SS-Chr 4BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 36.07 ml/min 2.88 9.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20280 381
FHH-Chr 11BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 40.76 ml/min 3.34 10.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20283 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 23.31 ml/min 1.35 5.71 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20288 381
FHH-Chr 7BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 24.41 ml/min 2.47 6.98 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20291 381
FHH-Chr 6BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 -0.07 degrees C 0.29 0.97 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20297 381
SS-Chr 5BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.13 degrees C 0.41 1.3 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20304 381
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 51.25 ml/min 3.04 11.78 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 19297 381
Crl:CD(SD) percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 %change=VE during 2-3 min hypoxia/control during standard conditions 132.62 % 6.27 22.61 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19302 381
F344/DuCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 %change=VE during 2-3 min hypoxia/control during standard conditions 134.28 % 3.49 13.97 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19303 381
SS-Chr 10BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 -50.76 mmHg 2.58 7.29 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19437 381
SS-Chr 17BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 -41.13 mmHg 13.29 23.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19449 381
FHH-Chr 16BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 4 -44.32 mmHg 1.07 2.14 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19450 381
SS-Chr 17BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 2 -37.3 mmHg 6.1 8.63 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19454 381
SS-Chr 5BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 2 -30.72 mmHg 4.68 6.61 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19456 381
SS-Chr 5BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 1 -34.8 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19461 381
FHH-Chr 16BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 -38.58 mmHg 2.97 8.41 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19462 381
SS-Chr 16BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 5 34.04 mmHg 4.13 9.23 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18169 381
Crl:CD(SD) respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 152.33 breaths/min 6.32 22.79 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18208 381
SHR/NCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 37.26 degrees C 0.12 0.37 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18232 381
FHH-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 171.76 breaths/min 14.25 45.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18252 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 123.6 breaths/min 10.34 35.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18255 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 20 161.36 breaths/min 6.82 30.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18259 381
FHH-Chr XBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 161.76 breaths/min 10.0 31.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18261 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 143.17 breaths/min 5.72 24.28 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18262 381
FHH-Chr 10BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 144.89 breaths/min 7.52 23.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18264 381
FHH-Chr 8BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 135.48 breaths/min 3.06 9.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18270 381
SS-Chr 13BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 123.41 breaths/min 8.67 27.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18272 381
SS-Chr 13BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 131.42 breaths/min 8.08 24.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18277 381
FHH-Chr 4BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 134.77 breaths/min 13.24 45.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18283 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 111.63 breaths/min 8.21 25.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18284 381
SS-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 103.16 breaths/min 2.39 8.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18292 381
SS-Chr 16BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 6 123.87 breaths/min 6.39 15.65 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18148 381
SS-Chr 16BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 121.01 breaths/min 6.98 15.61 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18150 381
LE/BluGill heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 11 6.33 g/kg 0.73 2.43 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49148 461
FHH-Chr 20BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 -0.43 degrees C 0.22 0.8 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20315 381
SS-Chr 20BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 14 -0.13 degrees C 0.12 0.43 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20320 381
FHH-Chr YBN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 21 0.16 degrees C 0.12 0.53 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20322 381
SS-Chr 19BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 0.26 degrees C 0.12 0.35 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20331 381
SS-Chr 2BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 -0.53 degrees C 0.29 1.0 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20332 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 14 0.03 degrees C 0.19 0.73 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20333 381
FHH-Chr 5BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.49 degrees C 0.27 0.86 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20339 381
SS-Chr 14BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 -0.14 degrees C 0.27 0.84 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20341 381
LEW/Crl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 1 -0.1 degrees C digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20342 381
SS-Chr 9BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 14 -0.36 degrees C 0.14 0.54 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20344 381
SS-Chr 17BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 0.12 degrees C 0.35 1.22 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20352 381
FHH-Chr 13BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 -0.24 degrees C 0.13 0.41 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20369 381
SS-Chr 3BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 -0.15 degrees C 0.22 0.72 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20371 381
FHH-Chr 7BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 -0.02 degrees C 0.19 0.64 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20387 381
Hsd:SD absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 12 -47.88 mmHg 2.49 8.64 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20408 381
SS-Chr 6BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 11 57.31 mmHg 1.18 3.91 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20452 381
SS-Chr 5BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 2 60.43 mmHg 5.98 8.45 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20468 381
FHH-Chr 16BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 52.39 mmHg 2.32 6.57 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20474 381
FHH-Chr 13BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 53.02 mmHg 2.01 4.92 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20485 381
FHH/EurMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 16 51.87 mmHg 1.3 5.22 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20496 381
SS-Chr YBN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 15 57.2 mmHg 1.03 3.99 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20498 381
SS-Chr 18BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 10 57.54 mmHg 1.58 4.99 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20500 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 58.85 mmHg 1.0 2.82 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20509 381
FHH-Chr 11BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 5 59.33 mmHg 1.44 3.21 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20512 381
BN/NHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 12 54.33 mmHg 1.8 6.25 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20519 381
SS-Chr 2BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 56.5 mmHg 1.41 4.69 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20523 381
SS-Chr 16BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20540 381
FHH/EurMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 0.05 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20544 381
BN/NHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 0.05 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20545 381
FHH-Chr 19BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 -43.38 mmHg 3.67 10.39 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19465 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 16 -46.33 mmHg 4.5 18.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19484 381
FHH-Chr 11BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 2 -38.3 mmHg 2.1 2.97 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19496 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 -48.84 mmHg 4.39 11.61 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19497 381
SS-Chr 19BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 1 -41.1 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19502 381
SS-Chr 4BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 17 24.43 % 2.38 9.81 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49768 461
FHH-Chr 11BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 3.92 % 1.46 4.39 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49771 461
WKY/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 152.96 mmHg 6.9 20.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49800 461
Crl:CD(SD) left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 148.93 mmHg 4.34 13.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49804 461
LE/BluGill left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 129.84 mmHg 4.01 9.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49806 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 54.4 mmHg 9.24 20.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49821 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 12 100.35 mmHg 12.99 45.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49874 461
FHH-Chr 6BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 99.88 mmHg 4.76 15.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49876 461
SHR/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 111.5 mmHg 4.44 16.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49885 461
FHH-Chr 10BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 79.11 mmHg 6.71 18.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49887 461
FHH-Chr 8BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 77.91 mmHg 11.13 33.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49893 461
FHH-Chr 4BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 88.16 mmHg 9.01 23.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49904 461
FHH-Chr 15BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 9 100.8 g 8.3 25.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49491 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 15 163.2 g 2.0 7.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49502 461
SS-Chr 7BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 164.6 g 2.0 6.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49522 461
FHH-Chr 13BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 170.6 g 6.2 19.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49544 461
FHH-Chr YBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 14 98.1 g 2.6 9.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49554 461
SS/JrHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 85 199.8 g 3.9 36.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49558 461
FHH-Chr 7BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 131.5 g 2.7 8.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49575 461
WKY/NCrl percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 70.12 % 10.38 31.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49260 461
LEW/Crl percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 91.72 % 4.83 14.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49261 461
Crl:CD(SD) percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 131.59 % 25.95 82.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49262 461
Crl:CD(SD) percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 96.68 % 10.15 32.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49264 461
LEW/Crl percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 97.97 % 24.49 77.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49267 461
Crl:CD(SD) left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 91.21 mmHg 7.78 24.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49274 461
Crl:CD(SD) left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 95.76 mmHg 10.85 32.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49276 461
LE/BluGill left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 100.76 mmHg 6.27 20.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49278 461
WKY/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 106.02 mmHg 9.92 31.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49280 461
FHH-Chr 6BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 789.88 s 47.62 134.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49288 461
FHH-Chr 10BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 4 773.25 s 145.26 290.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49292 461
FHH-Chr 8BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 902.75 s 95.28 269.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49300 461
FHH-Chr 8BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 971.44 s 41.33 123.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49304 461
FHH-Chr 4BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 987.9 s 32.19 101.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49317 461
FHH-Chr 16BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 19 921.74 s 24.03 104.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49342 461
SS-Chr 7BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 11 958.82 s 40.18 133.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49344 461
SS-Chr 7BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 840.4 s 50.31 159.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49348 461
SS-Chr 3BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 6 844.83 s 29.58 72.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49354 461
FHH-Chr 7BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 1013.7 s 37.05 117.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49375 461
WKY/NCrl heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 30.88 mmHg 3.33 9.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49587 461
WKY/NCrl heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 27.38 mmHg 4.12 11.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49595 461
SS-Chr 16BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 16.57 % 2.55 8.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 49631 461
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 124.98 mmHg 8.52 24.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49649 461
Crl:CD(SD) percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 58.7 % 10.36 32.75 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49655 461
WKY/NCrl percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 69.93 % 6.45 20.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49659 461
SS-Chr 5BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 16.26 % 3.05 9.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49693 461
FHH-Chr 8BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 1.83 % 1.35 4.26 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49699 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 12 11.36 % 3.7 12.83 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49717 461
SS-Chr 19BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 9 18.89 % 2.12 6.36 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49718 461
SS-Chr 19BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 20.7 % 2.78 8.79 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49720 461
FHH-Chr 1BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 9.2 % 4.39 13.88 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49724 461
FHH-Chr 15BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 8 10.98 % 3.68 10.42 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49726 461
SS-Chr 14BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 15 11.88 % 2.27 8.78 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49730 461
FHH-Chr 16BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 19 13.4 % 2.01 8.74 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49741 461
FHH-Chr 11BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 36.3 mmHg 3.04 9.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50069 461
FHH-Chr 7BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 32.8 mmHg 2.61 8.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50073 461
WKY/NCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 131.0 g 6.8 21.4 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50086 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 4 0.28 IU/g 0.05 0.1 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50090 461
FHH-Chr 2BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1256.8 s 42.07 133.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50214 461
FHH-Chr 10BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 4 1000.25 s 167.56 335.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50220 461
FHH-Chr XBN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 1330.75 s 39.55 111.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50227 461
SS-Chr 20BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 23 1003.02 s 21.48 103.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50229 461
FHH-Chr 20BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1197.0 s 39.77 125.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50233 461
SS-Chr 18BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 1071.31 s 63.1 189.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50241 461
SS-Chr 12BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1079.9 s 30.41 96.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50252 461
SS-Chr 10BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 998.0 s 65.6 196.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50256 461
FHH-Chr 14BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 4 1097.42 s 143.23 286.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50258 461
SS-Chr 6BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 1336.67 s 53.2 159.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50260 461
FHH-Chr 17BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 19 1179.79 s 46.27 201.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50275 461
FHH-Chr 19BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1248.8 s 53.38 168.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50279 461
SS-Chr 3BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1134.3 s 50.23 158.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50287 461
SS-Chr XBN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1161.9 s 36.98 116.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50295 461
LE/BluGill absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.1 degrees C 0.2 0.63 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19159 381
SS-Chr 19BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 95.37 mmHg 4.9 13.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49910 461
FHH-Chr 1BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 103.64 mmHg 6.21 19.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49914 461
SS-Chr 6BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 114.94 mmHg 3.68 10.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49926 461
FHH-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 94.14 mmHg 14.37 32.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49941 461
FHH-Chr 9BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 68.67 mmHg 10.99 32.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49968 461
Crl:CD(SD) heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 257.17 beats/min 13.09 41.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49972 461
LE/BluGill heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 254.68 beats/min 9.34 28.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49981 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 14 53.43 mmHg 3.22 12.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49987 461
SHR/NCrl heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 15 58.27 mmHg 3.26 12.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49994 461
SS-Chr 12BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 28.33 mmHg 3.4 10.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50018 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 12 45.92 mmHg 3.61 12.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50021 461
SS-Chr 6BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 57.8 mmHg 3.0 9.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50035 461
FHH-Chr 16BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 18 38.0 mmHg 2.47 10.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50040 461
FHH-Chr 17BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 17 39.0 mmHg 2.99 12.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50043 461
FHH-Chr 16BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 20 35.65 mmHg 1.84 8.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50047 461
SS-Chr 3BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 28.0 mmHg 1.77 5.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50052 461
SS-Chr 3BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 34.5 mmHg 3.14 9.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50057 461
SS-Chr XBN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 33.2 mmHg 2.48 7.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50065 461
FHH-Chr 19BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 22.4 mmol/l 0.72 2.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42119 401
SS-Chr 11BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 15 18.2 mmol/l 0.91 3.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42127 401
SS-Chr 1BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 6 20.17 mmol/l 0.87 2.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42130 401
SS-Chr 4BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 29 19.41 mmol/l 0.49 2.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42133 401
FHH-Chr 7BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 19.2 mmol/l 0.39 1.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42139 401
SS-Chr 5BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 4.05 g/dl 0.03 0.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42228 401
SS-Chr 15BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.65 g/dl 0.06 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42236 401
FHH-Chr 20BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 4.08 g/dl 0.04 0.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42242 401
SS-Chr 18BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.57 g/dl 0.14 0.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42247 401
FHH-Chr 4BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 7 3.64 g/dl 0.09 0.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42251 401
SS-Chr 13BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 11 60.64 fl 0.61 2.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38757 401
SS-Chr 18BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 60.85 fl 0.24 0.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38762 401
FHH-Chr 4BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 7 58.51 fl 0.24 0.63 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38763 401
SS-Chr 19BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 60.06 fl 0.38 1.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38765 401
SS-Chr 2BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 62.46 fl 0.45 1.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38768 401
FHH-Chr 1BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 9 58.19 fl 0.41 1.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38771 401
FHH-Chr 5BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 59.93 fl 0.44 1.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38775 401
SS-Chr 14BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 17 58.81 fl 1.7 7.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38777 401
FHH-Chr 5BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 59.34 fl 0.43 1.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38780 401
SS-Chr 17BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 61.18 fl 0.72 2.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38787 401
SS-Chr 7BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 11 63.75 fl 0.44 1.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38790 401
SS-Chr YBN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 20 60.27 fl 0.52 2.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38811 401
SS-Chr 1BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 6 66.47 fl 1.07 2.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38813 401
SS-Chr 4BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 27 61.78 fl 0.38 1.95 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38816 401
FHH-Chr 11BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 59.11 fl 0.47 1.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38819 401
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 15 56.82 % 0.48 1.86 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38851 401
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 56.96 % 0.99 3.13 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38854 401
F344/NHsd body weight controlled air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 body mass male 105 days 23 median 238.0 g body weighing method 0 0 66124 102
SS-Chr 7BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 11 58.92 % 1.0 3.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39036 401
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 56.07 % 0.44 1.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39063 401
SS-Chr 4BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 29 54.43 % 0.56 3.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39066 401
BN/NHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 13 54.18 % 0.53 1.91 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39070 401
WKY/NCrl serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 5.83 mmol/l 0.27 0.76 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39092 401
F344/DuCrl serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 18 4.16 mmol/l 0.14 0.58 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39095 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 106.9 mmol/l 0.81 2.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39107 401
FHH-Chr 2BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 109.0 mmol/l 1.1 3.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39109 401
FHH-Chr 10BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 109.13 mmol/l 0.3 0.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39116 401
FHH-Chr 18BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 108.6 mmol/l 0.4 1.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39127 401
FHH-Chr 4BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 108.25 mmol/l 0.56 1.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39133 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 9 109.22 mmol/l 0.43 1.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39136 401
SS-Chr 12BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 107.5 mmol/l 0.33 0.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39138 401
FHH-Chr 15BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 107.38 mmol/l 0.63 1.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39145 401
FHH-Chr 5BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 107.75 mmol/l 0.67 1.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39147 401
SS-Chr 2BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 4.08 g/dl 0.03 0.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42256 401
SS-Chr 2BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 15 3.76 g/dl 0.04 0.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42260 401
FHH-Chr 14BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.06 g/dl 0.05 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42264 401
FHH-Chr 5BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.83 g/dl 0.06 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42268 401
FHH-Chr 17BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 6 3.8 g/dl 0.04 0.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42281 401
SS-Chr 3BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 7 3.86 g/dl 0.11 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42289 401
SS-Chr 3BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 6 3.77 g/dl 0.13 0.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42294 401
SS/JrHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 96 3.7 g/dl 0.02 0.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42300 401
FHH-Chr 7BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.92 g/dl 0.04 0.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42310 401
SS/JrHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 42.0 U/l 2.31 7.3 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42345 401
LEW/Crl serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 293.9 U/l 11.06 34.96 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42352 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 60.38 fl 0.8 2.53 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38735 401
FHH-Chr 10BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 7 57.57 fl 0.6 1.6 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38738 401
SHR/NCrl mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 18 53.99 fl 0.35 1.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38739 401
FHH-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 52.74 % 1.18 3.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38978 401
FHH-Chr XBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 7 51.94 % 0.78 2.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38991 401
FHH-Chr 14BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 51.7 % 1.2 3.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39022 401
FHH-Chr 5BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 52.28 % 1.37 3.87 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39026 401
FHH-Chr 2BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 16.75 mmol/l 0.65 1.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42049 401
SHR/NCrl serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 20 16.1 mmol/l 0.61 2.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42056 401
FHH-Chr 10BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 18.88 mmol/l 0.61 1.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42061 401
FHH-Chr 20BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 16.6 mmol/l 0.78 2.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42068 401
SS-Chr 19BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 20.5 mmol/l 0.81 2.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42082 401
FHH-Chr 5BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 19.75 mmol/l 0.59 1.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42097 401
FHH-Chr 16BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 9 19.22 mmol/l 1.09 3.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42105 401
FHH-Chr 8BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 18.22 pg 0.07 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42550 401
SS-Chr 20BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 33 19.43 pg 0.08 0.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42556 401
SS-Chr 18BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 20.27 pg 0.19 0.59 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42559 401
FHH-Chr 4BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.31 pg 0.08 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42561 401
SS-Chr 19BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 19.91 pg 0.15 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42567 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 18.99 pg 0.16 0.54 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42569 401
SS-Chr 12BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 20.56 pg 0.35 0.92 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42570 401
FHH-Chr 15BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.63 pg 0.11 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42573 401
SS-Chr 14BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 20 19.19 pg 0.08 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42581 401
SS-Chr 9BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 15 19.73 pg 0.1 0.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42582 401
SS-Chr 6BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 20.27 pg 0.21 0.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42583 401
FHH-Chr 15BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 18.76 pg 0.25 0.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42584 401
SS-Chr 17BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 20.58 pg 0.56 1.59 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42587 401
SS-Chr 17BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 20.66 pg 0.67 1.89 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42592 401
SS-Chr 11BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 17 20.12 pg 0.11 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42607 401
SS-Chr 11BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 19.75 pg 0.13 0.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42610 401
SS-Chr 1BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 20.5 pg 0.23 0.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42615 401
FHH-Chr 9BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 18.22 pg 0.23 0.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42621 401
BN/NHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 13 18.26 pg 0.09 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42624 401
FHH-Chr 9BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 6 18.15 pg 0.16 0.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42626 401
LEW/Crl mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 32.29 g/dl 0.09 0.27 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42735 401
SS/JrHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 2 1.65 x 1000 cells/ul 0.46 0.64 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 42749 401
FHH/EurMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 7 1.21 x 1000 cells/ul 0.31 0.82 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 42750 401
FHH/EurMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 7 0.96 x 1000 cells/ul 0.2 0.52 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 42753 401
FHH-Chr 12BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 12 82.08 U/l 2.68 9.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42755 401
SHR/NCrl serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 16 166.44 U/l 9.55 38.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42767 401
SS-Chr 15BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 74.38 U/l 5.98 16.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42774 401
FHH-Chr 18BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 93.7 U/l 3.95 12.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42778 401
FHH-Chr 1BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 14 127.93 U/l 10.54 39.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42785 401
FHH/EurMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 47 9.69 x 10E6 cells/ul 0.09 0.63 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39300 401
FHH-Chr 11BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 8.7 x 10E6 cells/ul 0.27 0.84 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39311 401
FHH-Chr 9BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 6 9.49 x 10E6 cells/ul 0.25 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39318 401
Hsd:SD mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 4 34.63 g/dl 1.12 2.24 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42503 401
FHH-Chr 6BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 18.41 pg 0.1 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42533 401
FHH-Chr 2BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.36 pg 0.08 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42537 401
FHH-Chr 15BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 116.38 U/l 6.75 19.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42798 401
FHH-Chr 5BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 92.75 U/l 5.59 15.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42800 401
SS-Chr 6BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 72.25 U/l 2.67 7.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42808 401
SS-Chr 10BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 59.1 U/l 3.08 9.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42810 401
FHH-Chr 14BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 112.0 U/l 9.98 28.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42811 401
FHH-Chr 16BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 9 91.78 U/l 4.57 13.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42813 401
GH/OmrMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 16 151.44 U/l 14.22 56.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42814 401
GH/OmrMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 18 122.67 U/l 11.17 47.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42819 401
FHH-Chr 3BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 85.25 U/l 3.63 10.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42824 401
SS-Chr YBN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 19 95.21 U/l 6.42 27.99 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42836 401
FHH-Chr 16BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 9 109.11 mmol/l 0.54 1.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39160 401
FHH-Chr 17BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 6 110.17 mmol/l 0.79 1.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39165 401
FHH-Chr 19BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 108.8 mmol/l 0.33 1.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39170 401
SS/JrHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 96 107.97 mmol/l 0.29 2.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39184 401
FHH-Chr 9BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 7 110.14 mmol/l 1.01 2.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39198 401
LEW/Crl serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.87 g/dl 0.07 0.23 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39218 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 14 8.61 x 10E6 cells/ul 0.24 0.9 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39223 401
SS-Chr 5BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 8.54 x 10E6 cells/ul 0.11 0.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39232 401
SHR/NCrl red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 15 10.55 x 10E6 cells/ul 0.16 0.6 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39234 401
SS-Chr 19BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 8.62 x 10E6 cells/ul 0.09 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39259 401
GH/OmrMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 12 9.91 x 10E6 cells/ul 0.22 0.77 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39281 401
SS-Chr 16BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 13 9.6 x 10E6 cells/ul 0.06 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39295 401
SS-Chr 11BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 17 8.45 x 10E6 cells/ul 0.18 0.73 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39299 401
Hsd:SD blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 5 17.64 g/dl 3.77 8.42 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39371 401
Hsd:SD blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 4 20.4 g/dl 1.16 2.33 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39372 401
SHR/NCrl serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 17 142.41 mmol/l 0.55 2.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39385 401
FHH-Chr XBN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 7 143.43 mmol/l 0.78 2.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39388 401
SS-Chr 13BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 11 145.64 mmol/l 1.04 3.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39400 401
FHH-Chr 15BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 140.63 mmol/l 0.38 1.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39416 401
SS-Chr 14BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 20 142.55 mmol/l 0.59 2.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39424 401
WKY/NCruk mean arterial blood pressure controlled air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 arterial blood pressure trait male 105 days 28 median 78.0 mmHg vascular indwelling catheter method left common carotid artery 0 0 66130 102
SS-Chr 10BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 105.9 mmol/l 0.35 1.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39157 401
SS-Chr 3BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 7 144.0 mmol/l 0.58 1.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39444 401
SS-Chr 16BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 14 142.36 mmol/l 1.1 4.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39446 401
SS-Chr 11BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 15 142.47 mmol/l 0.52 2.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39453 401
BN/NHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 20 144.75 mmol/l 0.42 1.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39466 401
SS/JrHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 24.2 mmol/l 1.03 3.26 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39488 401
F344/DuCrl total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 14 4.26 x 1000 cells/ul 0.4 1.5 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39492 401
WKY/NCrl total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 9 3.38 x 1000 cells/ul 0.36 1.08 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39496 401
Hsd:SD blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 16 0.3 x 1000 cells/ul 0.04 0.17 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39537 401
FHH-Chr 1BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 9 0.26 x 1000 cells/ul 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39700 401
SS-Chr 10BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.3 x 1000 cells/ul 0.14 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39703 401
FHH-Chr 14BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.22 x 1000 cells/ul 0.05 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39705 401
SS-Chr 9BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 15 0.46 x 1000 cells/ul 0.05 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39711 401
FHH-Chr 15BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.59 x 1000 cells/ul 0.19 0.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39713 401
SS-Chr 17BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.21 x 1000 cells/ul 0.06 0.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39716 401
FHH-Chr 17BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 6 0.22 x 1000 cells/ul 0.04 0.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39722 401
SS-Chr 11BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 16 0.22 x 1000 cells/ul 0.03 0.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39736 401
SS/JrHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.23 x 1000 cells/ul 0.04 0.14 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39746 401
FHH-Chr 7BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.21 x 1000 cells/ul 0.05 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39751 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 14 32.41 g/dl 0.18 0.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39763 401
FHH-Chr 6BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 31.89 g/dl 0.07 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39766 401
FHH-Chr 12BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 32.27 g/dl 0.07 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39768 401
SS-Chr 20BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.85 g/dl 0.13 0.37 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42961 401
FHH-Chr 7BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 31.8 g/dl 0.07 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39854 401
BN/NHsdMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 32.27 g/dl 0.09 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39855 401
SS-Chr XBN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 33.35 g/dl 0.15 0.46 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39857 401
SS/JrHsdMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 4 2.78 g/dl 0.18 0.36 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Dyets 39963 401
SS/JrHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 9 94.67 mg/dl 7.01 21.04 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43103 401
SS/JrHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 86.6 mg/dl 4.04 12.77 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43107 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 14 0.72 x 1000 cells/ul 0.1 0.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43210 401
FHH-Chr 6BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 9 0.4 x 1000 cells/ul 0.04 0.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43213 401
FHH-Chr 2BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 1.35 x 1000 cells/ul 0.15 0.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43216 401
SHR/NCrl blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 15 0.8 x 1000 cells/ul 0.14 0.55 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43221 401
FHH-Chr 8BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.59 x 1000 cells/ul 0.08 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43225 401
FHH-Chr 20BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 0.88 x 1000 cells/ul 0.1 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43230 401
SS-Chr 18BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 0.77 x 1000 cells/ul 0.11 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43238 401
SS-Chr 2BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.46 x 1000 cells/ul 0.09 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43247 401
FHH-Chr 15BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 1.35 x 1000 cells/ul 0.18 0.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43252 401
FHH-Chr 14BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.87 x 1000 cells/ul 0.15 0.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43255 401
SS-Chr 6BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 7 0.79 x 1000 cells/ul 0.1 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43262 401
SS-Chr 7BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 11 0.93 x 1000 cells/ul 0.08 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43269 401
SS-Chr 7BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 12 0.51 x 1000 cells/ul 0.08 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43274 401
FHH-Chr 19BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 1.41 x 1000 cells/ul 0.42 1.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43277 401
F344/DuCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 124.71 % 5.33 22.61 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54522 381
FHH-Chr 2BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 32.25 g/dl 0.15 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39769 401
FHH-Chr 20BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 31.75 g/dl 0.07 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39786 401
SS-Chr 19BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 32.05 g/dl 0.08 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39799 401
SS-Chr 9BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 17 32.21 g/dl 0.06 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39811 401
SS-Chr 9BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 15 32.14 g/dl 0.1 0.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39814 401
SS-Chr 10BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 31.88 g/dl 0.12 0.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39817 401
FHH-Chr 16BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 31.81 g/dl 0.1 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39820 401
SS-Chr 17BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 33.14 g/dl 0.65 1.85 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39824 401
FHH-Chr 3BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 32.59 g/dl 0.25 0.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39831 401
SS-Chr 16BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 13 32.73 g/dl 0.26 0.96 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39835 401
SS-Chr 11BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 32.32 g/dl 0.12 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39842 401
FHH-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 140.15 % 9.57 30.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54316 381
FHH-Chr 8BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 128.56 % 7.44 22.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54332 381
FHH-Chr 20BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 129.01 % 5.06 14.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54337 381
FHH-Chr YBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 21 131.81 % 6.11 28.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54342 381
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 125.74 % 3.95 16.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54346 381
FHH-Chr 15BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 126.71 % 5.71 18.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54355 381
FHH-Chr 14BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 131.67 % 5.51 17.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54358 381
SS-Chr 14BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 120.79 % 8.02 25.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54359 381
FHH-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 147.75 % 10.04 31.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54379 381
SS-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 117.12 % 6.91 23.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54382 381
FHH-Chr 9BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 132.19 % 6.72 20.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54406 381
FHH-Chr 7BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 124.2 % 5.3 14.98 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54407 381
SS/JrHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 90 0.89 x 1000 cells/ul 0.04 0.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43291 401
SS-Chr XBN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 11 0.77 x 1000 cells/ul 0.1 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43293 401
BN/NHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 15 1.01 x 1000 cells/ul 0.51 1.97 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43302 401
SS/JrHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.14 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Dyets 59036 526
FHH-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 128.9 g 4.2 13.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59049 526
SS-Chr 5BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 169.5 g 4.2 13.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59057 526
FHH-Chr 18BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 161.4 g 6.8 21.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59070 526
SS-Chr 20BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 44 234.5 g 3.7 24.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59073 526
SS-Chr 13BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 11 255.3 g 5.7 18.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59074 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 9 166.3 g 3.2 9.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59081 526
FHH-Chr 15BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 110.6 g 4.8 15.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59090 526
SS-Chr 9BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 18 202.0 g 5.9 25.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59096 526
SS-Chr 7BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 12 205.5 g 5.6 19.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59107 526
GH/OmrMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 34 205.0 g 4.5 26.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59111 526
SS-Chr 16BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 16 196.6 g 1.9 7.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59117 526
SS-Chr YBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 20 263.4 g 4.0 17.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59128 526
SS-Chr XBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 15 159.8 g 7.1 27.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59131 526
SS/JrHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 182.2 g 1.7 5.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59134 526
SS-Chr XBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 167.1 g 5.8 18.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59142 526
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 99.83 % 5.2 15.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54546 381
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 122.06 % 6.84 19.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54562 381
GH/OmrMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 130.39 % 5.48 14.49 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53539 381
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 113.69 % 6.36 19.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53543 381
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 113.35 % 4.12 10.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53548 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 119.75 % 7.07 22.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53551 381
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 118.15 % 4.62 17.89 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53570 381
LE/BluGill percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 145.48 % 8.81 27.86 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53600 381
WKY/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 20 111.74 % 2.95 13.19 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53610 381
SS-Chr 16BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 6 82.67 U/l 10.98 26.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 43413 401
SS-Chr 16BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 7 0.46 null 0.04 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 58888 526
FHH-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.66 mg/kg 0.28 0.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58912 526
SS-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 38 1.67 mg/kg 0.25 1.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58917 526
SS-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 11 1.73 mg/kg 0.14 0.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58933 526
FHH-Chr 17BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.32 mg/kg 0.36 1.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58954 526
FHH-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.96 mg/kg 0.37 1.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58957 526
SS/JrHsdMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 4 0.35 mg/dl 0.12 0.24 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Dyets 40377 401
SS/JrHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 2 0.37 x 1000 cells/ul 0.05 0.07 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40383 401
BN/NHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 19 2.97 mg/kg 0.71 3.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58985 526
FHH-Chr 9BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 6 4.32 mg/kg 1.59 3.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58987 526
FHH-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 19 129.03 % 6.28 27.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53736 381
FHH-Chr 8BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.3 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39581 401
FHH-Chr 18BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.25 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39584 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 9 0.34 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39595 401
FHH-Chr 5BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.3 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39611 401
SS-Chr 14BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 19 0.31 mg/dl 0.02 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39612 401
GH/OmrMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 16 0.34 mg/dl 0.02 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39620 401
SS-Chr 17BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.43 mg/dl 0.04 0.12 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39623 401
SS-Chr 7BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 12 0.3 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39626 401
FHH-Chr 16BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 9 0.3 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39627 401
SS-Chr 3BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 7 0.31 mg/dl 0.01 0.04 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39632 401
FHH-Chr 13BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.31 mg/dl 0.02 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39636 401
SS-Chr 1BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 6 0.33 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39644 401
SS-Chr XBN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 11 0.33 mg/dl 0.02 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39645 401
FHH-Chr 11BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 9 0.32 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39649 401
FHH-Chr 9BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 7 0.3 mg/dl 0.02 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39657 401
SS-Chr 5BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.15 x 1000 cells/ul 0.05 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39669 401
SS-Chr 5BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 7 0.33 x 1000 cells/ul 0.07 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39672 401
SS-Chr 12BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.34 x 1000 cells/ul 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39695 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 55.21 % 1.97 6.24 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59243 526
FHH-Chr 6BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 9 52.89 % 0.72 2.15 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59246 526
SS-Chr 20BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 27 53.5 % 0.68 3.53 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59259 526
SS-Chr 15BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 56.14 % 0.78 2.47 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59260 526
FHH-Chr 8BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 53.77 % 0.92 2.9 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59262 526
SS-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 7 53.79 % 0.98 2.6 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59282 526
FHH-Chr 15BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 54.43 % 0.88 2.48 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59285 526
FHH-Chr 5BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 52.28 % 1.37 3.87 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59292 526
GH/OmrMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 17 59.13 % 0.86 3.54 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59301 526
FHH-Chr 17BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 6 54.32 % 0.44 1.07 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59303 526
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 16 52.99 % 0.9 3.61 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59309 526
FHH-Chr 19BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 50.75 % 0.9 2.86 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59314 526
SS-Chr 16BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 16 2.13 g/dl 0.03 0.12 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40605 401
FHH-Chr 19BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.24 g/dl 0.03 0.08 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40607 401
FHH-Chr 13BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.48 g/dl 0.04 0.13 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40610 401
SS-Chr XBN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 11 1.67 g/dl 0.07 0.24 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40619 401
FHH-Chr 7BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.45 g/dl 0.05 0.16 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40632 401
Hsd:SD serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 16 106.0 mmol/l 0.47 1.9 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40657 401
SS-Chr 14BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 17 6.29 x 1000 cells/ul 0.32 1.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40958 401
SS-Chr 9BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 17 8.65 x 1000 cells/ul 0.31 1.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40960 401
SS-Chr 6BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 7 6.91 x 1000 cells/ul 1.06 2.81 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40964 401
FHH-Chr 14BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 6.15 x 1000 cells/ul 0.49 1.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40967 401
FHH-Chr 17BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 6 6.15 x 1000 cells/ul 0.36 0.88 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40972 401
SS-Chr 7BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 12 6.27 x 1000 cells/ul 0.36 1.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40976 401
SS-Chr 3BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 7 7.23 x 1000 cells/ul 0.41 1.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40982 401
SS-Chr YBN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 20 7.26 x 1000 cells/ul 0.35 1.55 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40992 401
SS-Chr 1BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 6 5.97 x 1000 cells/ul 0.34 0.83 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40996 401
FHH-Chr 7BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 5.66 x 1000 cells/ul 0.29 0.92 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41003 401
FHH-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 51.36 % 1.44 4.07 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59321 526
Hsd:SD serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 5 91.0 mg/dl 11.77 26.32 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37528 401
Hsd:SD mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 19.85 pg 0.24 0.93 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37563 401
SS-Chr 20BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 21.21 pg 0.5 1.43 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37564 401
Hsd:SD serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 5 364.0 U/l 185.15 414.01 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37569 401
Hsd:SD serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 16 9.18 mg/dl 0.14 0.57 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37573 401
SS/JrHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 25.1 mg/dl 0.62 1.97 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40812 401
FHH-Chr 10BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 20.88 mg/dl 1.6 4.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40821 401
SS-Chr 15BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 23.6 mg/dl 1.33 4.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40831 401
SS-Chr 2BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 23.5 mg/dl 0.83 2.64 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40851 401
FHH-Chr 14BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 29.75 mg/dl 2.6 7.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40859 401
FHH-Chr 14BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 27.63 mg/dl 2.1 5.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40869 401
SS-Chr 17BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 26.0 mg/dl 2.9 8.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40875 401
FHH-Chr 19BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 21.9 mg/dl 1.48 4.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40881 401
SS-Chr 16BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 16 22.19 mg/dl 1.12 4.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40883 401
FHH-Chr 13BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 20.2 mg/dl 1.12 3.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40888 401
BN/NHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 17 24.0 mg/dl 0.92 3.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40907 401
FHH-Chr 10BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 7 9.24 x 1000 cells/ul 0.97 2.58 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40919 401
SS-Chr 5BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 7 7.33 x 1000 cells/ul 0.55 1.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40924 401
SS-Chr 15BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 6.26 x 1000 cells/ul 0.73 2.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40930 401
FHH-Chr 8BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 6.05 x 1000 cells/ul 0.36 1.14 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40931 401
FHH-Chr 4BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 7 4.19 x 1000 cells/ul 0.46 1.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40944 401
SS-Chr 12BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 8.46 x 1000 cells/ul 0.51 1.46 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40947 401
SS-Chr 19BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 5.41 x 1000 cells/ul 0.19 0.59 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40948 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 11 5.48 x 1000 cells/ul 0.61 2.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40950 401
SS-Chr 12BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 7 7.43 x 1000 cells/ul 0.47 1.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40951 401
SS-Chr 2BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 15 7.63 x 1000 cells/ul 0.42 1.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40953 401
FHH-Chr 15BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 8.34 x 1000 cells/ul 0.86 2.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40954 401
LEW/Crl blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 9 0.03 x 1000 cells/ul 0.02 0.05 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40502 401
SS-Chr 20BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 5.99 x 1000 cells/ul 0.43 1.22 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40514 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 14 2.21 g/dl 0.05 0.18 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40536 401
FHH-Chr 12BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 11 2.1 g/dl 0.05 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40541 401
SHR/NCrl serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 17 1.98 g/dl 0.03 0.14 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40547 401
FHH-Chr 4BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 7 1.39 g/dl 0.04 0.11 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40568 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 11 2.37 g/dl 0.04 0.13 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40574 401
FHH-Chr 5BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.34 g/dl 0.05 0.15 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40585 401
FHH-Chr 15BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.36 g/dl 0.04 0.12 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40589 401
FHH-Chr 14BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.76 g/dl 0.05 0.13 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40591 401
FHH-Chr XBN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 7 86.0 U/l 5.81 15.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40714 401
SS-Chr 15BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 119.1 U/l 39.24 124.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40717 401
FHH-Chr 8BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 53.7 U/l 3.11 9.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40719 401
FHH-Chr 18BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 62.7 U/l 1.56 4.92 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40722 401
FHH-Chr 4BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 51.38 U/l 2.89 8.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40730 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 9 45.0 U/l 3.02 9.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40733 401
SS-Chr 19BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 35.2 U/l 2.37 7.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40736 401
FHH-Chr 5BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 53.88 U/l 3.25 9.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40744 401
GH/OmrMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 18 69.17 U/l 3.66 15.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40763 401
SS-Chr 11BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 15 54.0 U/l 4.14 16.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40779 401
SS-Chr YBN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 20 58.15 U/l 3.46 15.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40780 401
SS-Chr 4BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 28 52.11 U/l 1.56 8.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40785 401
FHH-Chr 11BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 9 61.22 U/l 7.57 22.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40787 401
Crl:CD(SD) plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 9 0.29 mg/dl 0.02 0.06 automated plasma creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40799 401
F344/DuCrl plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 18 0.25 mg/dl 0.02 0.09 automated plasma creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40800 401
SS-Chr 5BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 10.41 mg/dl 0.51 1.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37589 401
FHH-Chr 8BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 8.19 mg/dl 0.28 0.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37599 401
SS-Chr 12BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 9.96 mg/dl 0.23 0.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37619 401
FHH-Chr 15BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 10.68 mg/dl 0.35 1.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37622 401
SS-Chr 14BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 20 9.49 mg/dl 0.29 1.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37630 401
FHH-Chr 16BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 9 7.52 mg/dl 0.28 0.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37637 401
SS-Chr 11BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 17 9.22 mg/dl 0.44 1.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37656 401
SS/JrHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 95 9.32 mg/dl 0.12 1.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37661 401
SS-Chr 1BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 6 10.15 mg/dl 0.36 0.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37662 401
SS-Chr XBN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 11 10.27 mg/dl 0.22 0.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37663 401
SS-Chr XBN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 10.26 mg/dl 0.42 1.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37674 401
FHH-Chr 9BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 7 10.11 mg/dl 0.25 0.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37675 401
SS-Chr 20BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 23.88 mg/dl 1.81 5.11 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40807 401
Hsd:SD red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 5 8.55 x 10E6 cells/ul 1.82 4.07 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37946 401
SHR/NCrl blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 18 19.41 g/dl 0.23 0.99 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37962 401
FHH-Chr XBN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 16.64 g/dl 0.29 0.77 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37968 401
FHH-Chr 8BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 16.81 g/dl 0.24 0.75 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37969 401
FHH-Chr YBN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 18.32 g/dl 0.27 0.8 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37981 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 18.66 g/dl 0.25 0.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37987 401
SS-Chr 12BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 17.66 g/dl 0.26 0.73 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37989 401
SS-Chr 2BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 18.7 g/dl 0.28 1.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37995 401
FHH-Chr 5BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 16.44 g/dl 0.38 1.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38003 401
FHH-Chr 16BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 16.72 g/dl 0.16 0.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38011 401
GH/OmrMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 16 19.28 g/dl 0.16 0.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38017 401
FHH/EurMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 16 17.0 g/dl 0.3 1.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38020 401
FHH-Chr 3BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 16.0 g/dl 0.51 1.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38022 401
SS-Chr 3BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 16.96 g/dl 0.27 0.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38024 401
FHH/EurMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 47 17.74 g/dl 0.17 1.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38031 401
SS-Chr 11BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 17.08 g/dl 0.26 0.99 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38033 401
BN/NHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 13 17.43 g/dl 0.15 0.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38047 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.15 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59566 526
SS-Chr 12BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.14 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59572 526
FHH-Chr 15BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.15 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59575 526
FHH-Chr 15BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.16 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59586 526
FHH/EurMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 11 0.19 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59599 526
SS-Chr 16BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 14 0.16 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59602 526
FHH-Chr 3BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.16 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59611 526
SS-Chr YBN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 20 0.15 mmHg x min x kg x ml-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59613 526
SS/JrHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 104 0.17 mmHg x min x kg x ml-1 0.0 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59614 526
FHH-Chr 7BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.15 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59624 526
BN/NHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 28 0.13 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59625 526
FHH-Chr 7BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.16 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59629 526
FHH-Chr 10BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.67 g/kg 0.04 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59650 526
SS-Chr 5BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.28 g/kg 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59655 526
SS-Chr 15BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 14 1.63 g/kg 0.03 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59661 526
FHH-Chr 20BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.51 g/kg 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59663 526
FHH-Chr YBN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 14 1.62 g/kg 0.03 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59670 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 9 1.45 g/kg 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59676 526
SS-Chr 12BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.25 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59678 526
SS-Chr 9BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 18 1.27 g/kg 0.03 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59691 526
Hsd:SD mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 32.08 g/dl 0.12 0.46 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41117 401
Hsd:SD mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 16 31.77 g/dl 0.16 0.64 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41119 401
Crl:CD(SD) serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 18.63 mmol/l 0.56 1.6 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41123 401
F344/DuCrl serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 18 3.79 g/dl 0.04 0.19 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41134 401
FHH/EurMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 7 4.95 x 1000 cells/ul 0.57 1.52 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41145 401
SS/JrHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 4 35.5 mg/dl 2.1 4.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 41380 401
SS/JrHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 7 28.86 mg/dl 1.92 5.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 41385 401
SS-Chr 14BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 20 1.26 g/kg 0.04 0.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59693 526
SS-Chr 7BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 12 1.64 g/kg 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59707 526
SS-Chr 11BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 20 1.49 g/kg 0.05 0.22 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59719 526
FHH-Chr 11BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.62 g/kg 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59730 526
SS-Chr 16BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 7 9.13 x 10E6 cells/ul 0.18 0.46 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 37918 401
FHH-Chr 6BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.19 mmol/l 0.13 0.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38055 401
SS-Chr 5BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 3.99 mmol/l 0.14 0.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38061 401
SS-Chr 5BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 4.6 mmol/l 0.22 0.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38064 401
FHH-Chr 18BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 4.83 mmol/l 0.22 0.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38074 401
FHH-Chr 4BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 5.03 mmol/l 0.15 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38082 401
SS-Chr 19BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.28 mmol/l 0.11 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38088 401
SS-Chr 6BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 4.89 mmol/l 0.14 0.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38104 401
FHH-Chr 15BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 5.11 mmol/l 0.36 1.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38105 401
SS-Chr 17BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 4.78 mmol/l 0.09 0.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38108 401
FHH-Chr 6BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.17 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59535 526
FHH-Chr 6BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.19 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59536 526
FHH-Chr 18BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.15 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59557 526
Hsd:SD serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 3 141.0 mmol/l 2.52 4.36 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37786 401
FHH-Chr 13BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 18.3 mmol/l 0.26 0.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38321 401
SS/JrHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 96 22.92 mmol/l 0.45 4.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38328 401
FHH-Chr 11BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 9 16.44 mmol/l 1.31 3.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38334 401
SS-Chr 16BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 6 54.92 % 0.58 1.42 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38356 401
Hsd:SD serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 3 104.33 mmol/l 1.2 2.08 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38375 401
FHH/EurMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 7 105.29 mmol/l 0.68 1.8 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 38413 401
SS-Chr 16BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 6 8.17 x 1000 cells/ul 0.31 0.76 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41484 401
FHH-Chr 6BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 9 5.48 x 1000 cells/ul 0.36 1.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41492 401
SS-Chr 5BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 5.14 x 1000 cells/ul 0.29 0.82 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41498 401
SS-Chr 18BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 4.16 x 1000 cells/ul 0.42 1.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41517 401
SS-Chr 2BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 15 5.73 x 1000 cells/ul 0.32 1.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41530 401
FHH-Chr 15BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 6.52 x 1000 cells/ul 0.73 2.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41531 401
SS-Chr 14BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 20 5.65 x 1000 cells/ul 0.43 1.93 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41539 401
SS-Chr 17BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 5.29 x 1000 cells/ul 0.87 2.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41545 401
FHH-Chr 17BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 6 5.02 x 1000 cells/ul 0.38 0.93 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41549 401
FHH/EurMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 16 3.07 x 1000 cells/ul 0.43 1.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41555 401
FHH-Chr 19BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 5.43 x 1000 cells/ul 0.43 1.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41560 401
SS/JrHsdMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 5.94 x 1000 cells/ul 0.77 2.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41575 401
FHH-Chr 11BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 4.26 x 1000 cells/ul 0.62 1.97 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41577 401
WKY/NCrl serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 64.5 U/l 3.54 11.21 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41598 401
F344/DuCrl serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 17 66.24 U/l 7.05 29.07 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41601 401
LE/BluGill serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 75.25 U/l 6.57 18.58 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41607 401
Hsd:SD blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 5 0.1 x 1000 cells/ul 0.03 0.08 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41608 401
GH/OmrMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 15 4.87 mmol/l 0.17 0.64 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38115 401
FHH-Chr 16BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 9 4.84 mmol/l 0.07 0.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38117 401
SS/JrHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 85 5.44 mmol/l 0.08 0.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38133 401
SS-Chr 1BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 6 4.7 mmol/l 0.35 0.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38136 401
SS-Chr XBN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 9 5.1 mmol/l 0.2 0.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38146 401
LEW/Crl red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 10.86 x 10E6 cells/ul 0.29 0.82 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38155 401
F344/DuCrl red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 12 10.38 x 10E6 cells/ul 0.13 0.45 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38157 401
FHH/EurMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 7 58.96 fl 0.34 0.91 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38168 401
WKY/NCrl serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 106.3 mmol/l 0.75 2.36 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38180 401
SS-Chr 20BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 8.75 x 10E6 cells/ul 0.19 0.53 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38190 401
SS-Chr 16BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 6 0.11 x 1000 cells/ul 0.04 0.1 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38198 401
Crl:CD(SD) blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 9 5.76 x 1000 cells/ul 0.38 1.15 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38218 401
WKY/NCrl serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 138.8 mmol/l 0.99 3.12 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38236 401
Crl:CD(SD) serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 9 140.0 mmol/l 0.91 2.74 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38240 401
FHH-Chr XBN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 171.63 mg/dl 14.05 39.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38526 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 13 0.01 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41633 401
FHH-Chr 6BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 9 0.04 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41636 401
SHR/NCrl blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 18 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41641 401
SS-Chr 5BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.03 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41642 401
FHH-Chr 18BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41655 401
SS-Chr 18BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.05 x 1000 cells/ul 0.02 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41664 401
LE/BluGill serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 141.8 mmol/l 0.51 1.62 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38245 401
FHH-Chr 2BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 22.5 mmol/l 0.57 1.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38253 401
SHR/NCrl plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 20 24.0 mmol/l 0.7 3.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38255 401
FHH-Chr XBN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 7 16.71 mmol/l 0.78 2.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38261 401
SS-Chr 15BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 20.7 mmol/l 1.02 3.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38264 401
FHH-Chr 20BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 19.9 mmol/l 0.5 1.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38270 401
SS-Chr 2BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 24.8 mmol/l 0.66 2.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38284 401
SS-Chr 14BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 17 19.29 mmol/l 0.79 3.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38293 401
SS-Chr 17BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 22.75 mmol/l 1.53 4.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38308 401
FHH-Chr 16BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 9 19.0 mmol/l 0.76 2.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38312 401
FHH/EurMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 18 19.89 mmol/l 1.23 5.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38313 401
SS-Chr 16BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 15 24.2 mmol/l 0.78 3.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38316 401
FHH-Chr 5BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.04 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41677 401
GH/OmrMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 12 0.03 x 1000 cells/ul 0.01 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41691 401
FHH-Chr 19BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.03 x 1000 cells/ul 0.02 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41700 401
SS-Chr XBN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 11 0.04 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41716 401
SS/JrHsdMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.03 x 1000 cells/ul 0.02 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41719 401
SS-Chr 4BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 29 0.01 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41722 401
FHH-Chr 7BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41945 401
BN/NHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 20 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41946 401
FHH/EurMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 5 1151.06 s 61.18 136.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45389 461
FHH-Chr 2BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 0.87 g 0.07 0.2 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45397 461
FHH-Chr XBN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.68 g 0.04 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45405 461
SS-Chr 20BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 23 1.07 g 0.03 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45407 461
SS-Chr 20BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 25 1.07 g 0.04 0.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45416 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 12 0.81 g 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45424 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 264.79 beats/min 37.41 105.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46631 461
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.59 IU/g 0.09 0.25 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47478 461
SS-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.25 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47495 461
FHH-Chr 9BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.58 IU/g 0.1 0.3 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47501 461
FHH-Chr 9BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.59 IU/g 0.09 0.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47509 461
SS-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.54 IU/g 0.09 0.3 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47510 461
WKY/NCrl percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 39.1 % 7.86 23.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47520 461
LEW/Crl percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 30.76 % 4.64 14.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47521 461
Crl:CD(SD) percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 25.51 % 8.58 27.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47524 461
Hsd:SD percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 2 post-ischemic value/pre-ischemic value x 100% 55.97 % 5.53 7.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47529 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 5.23 mmHg 0.51 1.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 47532 461
SS-Chr 16BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 3.68 mmHg 0.17 0.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 47534 461
GH/OmrMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 5.0 mmHg 0.22 0.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 47535 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 4.6 mmHg 0.54 1.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 47538 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 53.23 mmHg 4.01 13.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46436 461
SS-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 40.6 mmHg 6.49 20.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46438 461
FHH-Chr 17BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 16 52.93 mmHg 5.07 20.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46463 461
FHH-Chr 17BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 48.56 mmHg 3.7 14.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46465 461
FHH-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 37.89 mmHg 3.82 9.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46480 461
SS-Chr YBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 29 53.02 mmHg 2.78 14.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46482 461
SS-Chr XBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 40.77 mmHg 5.5 16.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46485 461
SS-Chr 1BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 64.61 mmHg 3.01 7.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46486 461
FHH-Chr 9BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 40.05 mmHg 2.51 7.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46492 461
FHH-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 45.31 mmHg 3.5 11.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46493 461
F344/DuCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 244.42 beats/min 21.66 68.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46502 461
LEW/Crl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 261.01 beats/min 18.47 52.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46506 461
F344/DuCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 200.77 beats/min 14.47 43.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46509 461
SS-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 11 345.9 beats/min 20.97 69.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46513 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 320.02 beats/min 37.3 91.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46516 461
FHH-Chr 15BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 31.21 % 5.65 12.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48566 461
SS-Chr 16BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 34.22 % 4.6 18.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48581 461
SS-Chr XBN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 57.01 % 7.15 21.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48595 461
FHH-Chr 11BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 27.9 % 5.1 12.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48600 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 13 131.21 mmHg 5.59 20.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48610 461
SHR/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 135.07 mmHg 6.34 19.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48618 461
SS-Chr 5BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 96.09 mmHg 5.9 17.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48619 461
SHR/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 12 128.51 mmHg 4.91 17.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48621 461
SS-Chr 13BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 12 127.83 mmHg 3.99 13.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48631 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 126.47 mmHg 6.1 19.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48643 461
SS-Chr 14BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 99.17 mmHg 6.66 22.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48660 461
SS-Chr 17BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 93.77 mmHg 4.95 15.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48666 461
SS-Chr 17BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 98.67 mmHg 4.75 14.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48671 461
FHH-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 97.39 mmHg 13.03 29.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48677 461
SS-Chr 4BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 88.56 mmHg 4.52 15.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48694 461
SS-Chr 4BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 102.8 mmHg 4.87 17.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48698 461
FHH-Chr 7BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 121.44 mmHg 4.38 13.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48700 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 95.45 mmHg 4.99 14.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48723 461
SS-Chr 16BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 144.17 mmHg 6.25 20.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48733 461
GH/OmrMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 227.67 mmHg 6.56 19.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48738 461
SS-Chr 19BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 149.4 mg/dl 4.19 13.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38552 401
FHH-Chr 15BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 124.75 mg/dl 5.5 15.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38558 401
FHH-Chr 5BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 8 131.75 mg/dl 3.44 9.74 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38560 401
SS-Chr 6BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 9 165.11 mg/dl 7.53 22.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38563 401
FHH-Chr 14BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 152.63 mg/dl 8.09 22.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38571 401
FHH-Chr 17BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 6 120.67 mg/dl 7.45 18.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38578 401
FHH-Chr 19BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 140.7 mg/dl 2.77 8.74 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38583 401
SS-Chr 16BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 16 154.31 mg/dl 5.6 22.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38585 401
SS-Chr YBN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 20 157.2 mg/dl 3.24 14.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38596 401
SS-Chr XBN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 11 144.64 mg/dl 5.31 17.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38599 401
FHH-Chr 11BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 223.6 mg/dl 40.31 127.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38604 401
SS-Chr 20BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 7 164.29 mg/dl 15.95 42.21 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38623 401
Hsd:SD serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 16 187.88 mg/dl 5.73 22.93 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38625 401
SS-Chr 13BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 12 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41875 401
FHH-Chr 20BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41877 401
FHH-Chr 18BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41878 401
SS-Chr 19BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.15 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41888 401
SS-Chr 2BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41891 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 11 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41892 401
FHH-Chr 5BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.11 mg/dl 0.01 0.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41903 401
SS-Chr 9BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 18 0.32 mg/dl 0.06 0.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41905 401
FHH-Chr 15BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.19 mg/dl 0.02 0.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41907 401
SS-Chr 7BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 11 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41913 401
FHH-Chr 19BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41925 401
SS-Chr 1BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 6 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41936 401
SS-Chr XBN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 11 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41937 401
FHH-Chr 14BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 0.52 g 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45436 461
FHH-Chr 17BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 20 1.02 g 0.05 0.23 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45453 461
FHH-Chr 16BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 20 0.95 g 0.03 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45455 461
FHH-Chr 19BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 1.02 g 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45457 461
SS-Chr 16BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 25 0.92 g 0.04 0.19 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45459 461
FHH-Chr 13BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 1.04 g 0.04 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45463 461
SS-Chr 3BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.75 g 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45465 461
SS-Chr 1BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 11 0.9 g 0.04 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45472 461
SS-Chr 4BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 19 0.78 g 0.02 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45479 461
FHH-Chr 7BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 1.04 g 0.04 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45486 461
FHH-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 212.35 beats/min 14.27 40.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47574 461
SS-Chr 20BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 23 263.21 beats/min 6.03 28.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47584 461
FHH-Chr YBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 245.52 beats/min 5.91 19.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47595 461
FHH-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 244.32 beats/min 6.26 17.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47655 461
Crl:CD(SD) left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 130.92 mmHg 5.55 17.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47666 461
FHH-Chr 12BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 32.38 % 5.22 14.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48518 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 39.61 % 6.46 20.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48546 461
SS-Chr 12BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 32.58 % 4.79 15.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48548 461
Hsd:SD heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 7 21.24 % 3.11 8.22 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48740 461
FHH-Chr 2BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 62.73 % 3.46 9.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48743 461
FHH-Chr 2BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 59.59 % 6.15 16.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48748 461
SHR/NCrl percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 73.89 % 3.8 11.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48750 461
SS-Chr 5BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 94.83 % 4.7 14.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48751 461
SHR/NCrl percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 13 post-ischemic value/pre-ischemic value x 100% 75.69 % 11.37 40.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48753 461
FHH-Chr 10BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 92.43 % 4.09 11.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48755 461
SS-Chr 18BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 62.85 % 13.13 39.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48770 461
FHH-Chr 4BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 85.92 % 7.78 20.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48772 461
SS-Chr 19BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 96.93 % 6.2 17.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48778 461
SS-Chr 9BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 73.91 % 5.74 24.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48790 461
SS-Chr 7BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 79.88 % 4.94 14.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48805 461
SS/JrHsdMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 84 post-ischemic value/pre-ischemic value x 100% 80.61 % 2.77 25.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48822 461
FHH-Chr 11BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 70.34 % 3.38 10.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48828 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 304.18 beats/min 25.52 76.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46632 461
FHH-Chr 13BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 18.19 ml/min/kg 0.94 2.99 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57657 526
FHH-Chr 12BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 16.94 ml/min/kg 0.59 2.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57583 526
FHH-Chr XBN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 13.29 ml/min/kg 1.71 4.53 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57594 526
SS-Chr 20BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 27 16.6 ml/min/kg 0.57 2.98 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57600 526
SS-Chr 13BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 14.98 ml/min/kg 0.3 1.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57605 526
SS-Chr 13BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 11.35 ml/min/kg 0.45 1.41 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57610 526
FHH-Chr 4BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 19.07 ml/min/kg 1.38 3.92 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57616 526
SS-Chr 2BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 11.62 ml/min/kg 1.2 3.78 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57621 526
FHH-Chr 1BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 13.84 ml/min/kg 0.9 2.84 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57624 526
FHH-Chr 14BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 5 17.5 ml/min/kg 1.12 2.5 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57629 526
SS-Chr 6BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 13.21 ml/min/kg 0.48 1.52 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57631 526
SS-Chr 6BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 9.6 ml/min/kg 0.89 2.67 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57636 526
FHH-Chr 17BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 18.47 ml/min/kg 0.97 3.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57646 526
FHH-Chr 9BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 17.3 ml/min/kg 1.62 3.98 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57674 526
SS-Chr XBN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 11.85 ml/min/kg 0.42 1.34 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57678 526
LEW/Crl calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.15 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57682 526
LE/BluGill calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 14 0.16 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57690 526
SS/JrHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 21.81 ml/min/kg 1.5 4.49 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 57716 526
LE/BluGill dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 12 6.24 mg/kg 1.7 5.88 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57772 526
SS-Chr 20BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 55.79 % 1.29 3.65 microhematocrit tube assay with visual assessment 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57775 526
SS-Chr 20BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 9 56.51 % 2.04 6.13 microhematocrit tube assay with visual assessment 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57778 526
Hsd:SD methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 10.22 ml/min/kg 0.81 1.99 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57783 526
SHR/NCrl methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 18 16.03 ml/min/kg 1.14 4.85 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57797 526
FHH-Chr XBN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 29.56 ml/min/kg 2.39 5.86 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57800 526
FHH-Chr 20BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 21.73 ml/min/kg 1.03 3.25 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57806 526
LE/BluGill heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 9 370.38 beats/min 12.06 36.18 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16127 381
F344/DuCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 11 407.25 beats/min 7.98 26.46 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16130 381
SS-Chr 7BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 30.31 ml/min/kg 1.68 5.81 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57850 526
SS-Chr 3BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 11 19.73 ml/min/kg 1.38 4.59 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57856 526
SS-Chr 11BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 17 30.98 ml/min/kg 1.25 5.14 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57862 526
BN/NHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 24 22.43 ml/min/kg 1.63 8.01 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57878 526
FHH-Chr 9BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 23.85 ml/min/kg 3.46 8.48 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57881 526
FHH-Chr 12BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 45.28 ml/min/kg 1.36 4.72 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57984 526
SS-Chr 1BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 39.22 degrees C 0.1 0.32 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16643 381
SS/JrHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 37.65 degrees C 0.13 0.43 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16645 381
FHH-Chr 11BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 36.27 degrees C 0.4 1.21 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16647 381
FHH-Chr 7BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 37.21 degrees C 0.16 0.52 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16650 381
LEW/Crl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 12 0.06 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16666 381
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.42 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 16324 381
Crl:CD(SD) partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 26.54 mmHg 1.24 3.27 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16367 381
SS-Chr 16BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 29.13 mmHg 0.27 0.67 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16452 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 5 27.91 mmHg 0.96 2.14 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16457 381
SS-Chr 18BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 16 16.98 ml/min/kg 1.51 6.04 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57817 526
SS-Chr 2BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 13.41 ml/min/kg 0.86 3.43 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57827 526
SS-Chr 9BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 11 11.41 ml/min/kg 1.63 5.41 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57834 526
SS-Chr 17BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 25.26 ml/min/kg 2.09 5.9 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57842 526
FHH-Chr 16BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 26.32 ml/min/kg 1.18 3.12 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57843 526
FHH-Chr 2BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 43.98 ml/min/kg 2.01 5.31 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57991 526
SS-Chr 5BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 55.93 ml/min/kg 6.51 19.53 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57994 526
SS-Chr 18BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 29.79 ml/min/kg 2.69 9.32 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58013 526
FHH-Chr 1BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 52.21 ml/min/kg 5.22 18.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58014 526
FHH-Chr 4BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 51.26 ml/min/kg 2.79 7.88 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58015 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 11 33.07 ml/min/kg 3.5 11.6 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58023 526
SS-Chr 10BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 65.56 ml/min/kg 4.55 12.88 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58039 526
FHH-Chr 16BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 48.92 ml/min/kg 2.39 7.17 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58050 526
FHH-Chr 13BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 59.29 ml/min/kg 4.9 15.49 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58059 526
FHH-Chr 11BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 68.92 ml/min/kg 7.35 20.8 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58072 526
FHH-Chr 9BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 78.74 ml/min/kg 7.82 19.15 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58075 526
Crl:CD(SD) fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58086 526
LEW/Crl fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.05 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58088 526
FHH-Chr 6BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.45 null 0.04 0.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58102 526
FHH-Chr 8BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.43 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58118 526
SS-Chr 18BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.33 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58130 526
FHH-Chr 5BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.64 null 0.09 0.27 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58143 526
SS-Chr 9BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.31 null 0.04 0.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58147 526
SS-Chr 10BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.42 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58153 526
FHH-Chr 16BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 0.46 null 0.01 0.04 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58156 526
FHH-Chr 19BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.44 null 0.03 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58166 526
FHH-Chr 3BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.49 null 0.03 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58167 526
SS/JrHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 91 0.43 null 0.02 0.21 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58180 526
SS-Chr XBN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 14 0.44 null 0.03 0.12 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58182 526
SS-Chr 1BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.44 null 0.01 0.03 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58183 526
SS-Chr 4BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 22 0.44 null 0.02 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58184 526
FHH-Chr 11BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.47 null 0.09 0.21 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58187 526
SS-Chr 4BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 16 0.44 null 0.03 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58188 526
FHH-Chr 7BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.46 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58190 526
Hsd:SD heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 7 0.38 null 0.02 0.05 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58316 526
SS-Chr 20BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 9 239.0 g 5.6 16.7 whole body digital scale 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58435 526
Hsd:SD methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 11.96 ml/min/kg 0.33 0.88 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58464 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 37.88 degrees C 0.19 0.67 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16562 381
SS-Chr 5BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.27 degrees C 0.25 0.75 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16570 381
FHH-Chr 10BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.2 degrees C 0.16 0.51 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16571 381
SS-Chr 13BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.43 degrees C 0.57 1.79 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16579 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 14 37.65 degrees C 0.16 0.6 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16596 381
SS-Chr 2BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 37.38 degrees C 0.12 0.42 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16599 381
SS-Chr 14BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.28 degrees C 0.12 0.36 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16604 381
FHH-Chr 14BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.31 degrees C 0.18 0.57 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16614 381
FHH-Chr 16BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.29 degrees C 0.23 0.7 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16624 381
FHH/EurMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 14 36.63 degrees C 0.26 0.96 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16625 381
Hsd:SD lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 5 1.14 g/kg 0.03 0.07 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58197 526
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 3 55.33 % 2.06 3.56 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Dyets 58198 526
FHH-Chr 2BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58481 526
SS-Chr 5BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58487 526
SS-Chr 15BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 8 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58493 526
SS-Chr 13BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58501 526
FHH-Chr YBN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58502 526
SS-Chr 18BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 18 0.05 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58503 526
FHH-Chr 4BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.04 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58505 526
SS-Chr 19BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58509 526
SS-Chr 19BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58511 526
FHH-Chr 5BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58519 526
FHH-Chr 14BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 5 0.02 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58520 526
SS-Chr 9BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 15 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58526 526
SS-Chr 7BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 12 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58534 526
GH/OmrMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 31 0.04 mmHg-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58538 526
SS-Chr 16BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 14 0.05 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58547 526
SS-Chr 11BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 17 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58551 526
FHH-Chr 7BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58571 526
Crl:CD(SD) hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 9 56.52 % 0.73 2.19 microhematocrit tube assay with visual assessment 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58584 526
SS-Chr 4BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 22 0.34 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58804 526
BN/NHsdMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 32 0.32 null 0.02 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58812 526
SS/JrHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 284.3 g 7.6 24.1 whole body digital scale 0 Moms and pups used in studies were fed Dyets 58818 526
Crl:CD(SD) methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 6.28 ml/min/kg 0.36 1.01 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58836 526
LEW/Crl methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 13.15 ml/min/kg 0.54 1.62 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58840 526
SS-Chr 16BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 6 1.31 g/kg 0.02 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 58875 526
FHH/EurMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 7 0.46 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 58889 526
FHH-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 2.88 mg/kg 0.7 1.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58893 526
SS-Chr 6BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 2.67 mg/kg 0.84 2.23 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58944 526
LE/BluGill heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 15 0.41 null 0.02 0.06 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59975 526
SS-Chr 20BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 8 1.22 g/kg 0.03 0.08 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58704 526
Hsd:SD lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 6 1.2 g/kg 0.07 0.16 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58705 526
SHR/NCrl heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 25 0.37 null 0.01 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58727 526
SS-Chr 12BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.43 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58754 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 12 0.33 null 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58757 526
SS-Chr 12BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.44 null 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58758 526
SS-Chr 2BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 16 0.34 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58760 526
FHH-Chr 5BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.46 null 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58763 526
SS-Chr 14BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 20 0.33 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58769 526
FHH-Chr 14BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.48 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58774 526
GH/OmrMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 34 0.33 null 0.01 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58782 526
FHH-Chr 19BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.4 null 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58790 526
LEW/Crl methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 10.21 ml/min/kg 0.47 1.42 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59866 526
F344/DuCrl methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 13 9.56 ml/min/kg 0.78 2.82 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59868 526
FHH-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 3.38 mg/kg 0.87 2.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58947 526
SS-Chr 17BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 0.69 mg/kg 0.1 0.28 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58953 526
SS/JrHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 2.6 null 0.52 1.39 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 60086 526
SS-Chr 16BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.86 null 0.09 0.22 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 60088 526
WKY/NCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 184.9 g 10.2 32.2 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60096 526
Crl:CD(SD) FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 45.0 ml/min/kg 7.34 23.21 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60132 526
GH/OmrMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 53.02 ml/min 2.81 7.42 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17474 381
WKY/NCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 0.32 ml 0.01 0.06 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16031 381
Crl:CD(SD) tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.3 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16036 381
WKY/NCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 20 0.25 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16039 381
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 5.93 ml/min/g 0.73 2.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44703 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 13 5.8 ml/min/g 0.47 1.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44704 461
FHH-Chr 6BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 6.22 ml/min/g 0.93 2.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44706 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 13 7.73 ml/min/g 0.51 1.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44708 461
SS-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 4.47 ml/min/g 0.63 1.88 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44713 461
SHR/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 13 8.75 ml/min/g 1.4 5.05 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44715 461
FHH-Chr 8BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 6.7 ml/min/g 1.28 4.05 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44719 461
SS-Chr 19BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 3.38 ml/min/g 0.27 0.72 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44738 461
SS-Chr 19BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 4.96 ml/min/g 0.4 1.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44740 461
SS-Chr 10BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 7.0 ml/min/g 0.5 1.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44747 461
FHH-Chr 14BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 6.86 ml/min/g 0.93 2.29 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44759 461
FHH-Chr 16BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 20 6.87 ml/min/g 0.58 2.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44761 461
BN/NHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 22 146.43 mmHg 3.24 15.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45806 461
GH/OmrMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 1.45 g 0.08 0.23 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 45833 461
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 285.31 beats/min 7.99 22.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45872 461
F344/DuCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 87.43 mmHg 9.01 25.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45911 461
LE/BluGill left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 59.68 mmHg 9.91 29.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45912 461
SS-Chr 18BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 56.19 % 12.59 35.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45923 461
LEW/Crl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 63.07 mmHg 2.12 6.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45938 461
F344/DuCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 37.33 mmHg 6.64 18.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45941 461
FHH-Chr 6BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 11 15.05 IU/g 0.99 3.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45956 461
FHH-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 6 13.84 IU/g 1.68 4.1 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45960 461
SS-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 4 25.4 IU/g 1.43 2.86 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45964 461
SS-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 4 19.38 IU/g 0.42 0.83 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45968 461
FHH-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 17 20.0 IU/g 2.15 8.86 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45970 461
FHH-Chr 10BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 15.03 IU/g 2.39 6.75 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45972 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 15 22.98 IU/g 2.94 11.39 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45976 461
FHH-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 10.85 IU/g 1.15 2.56 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45977 461
SS-Chr 3BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 15.78 IU/g 1.02 3.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45983 461
SS-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 7 15.8 IU/g 1.18 3.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46003 461
FHH-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 12.22 IU/g 1.74 4.93 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46005 461
SS-Chr 4BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 18 34.31 IU/g 2.47 10.46 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46006 461
FHH-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 12.53 ml/min/g 0.5 1.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46711 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 50 10.18 ml/min/g 0.32 2.26 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46715 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 25 11.17 ml/min/g 0.52 2.6 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46717 461
FHH-Chr 9BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 12.26 ml/min/g 1.18 3.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46728 461
FHH-Chr 6BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 133.14 mmHg 6.93 23.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45717 461
FHH-Chr XBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 114.48 mmHg 7.03 19.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45725 461
FHH-Chr YBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 94.77 mmHg 5.77 19.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45742 461
SS-Chr 10BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 118.1 mmHg 5.2 12.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45758 461
FHH-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 134.35 mmHg 9.39 26.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45759 461
SS-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 12 104.88 mmHg 5.94 20.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45761 461
SS-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 12 101.63 mmHg 6.75 23.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45765 461
FHH-Chr 16BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 110.42 mmHg 7.3 24.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45772 461
GH/OmrMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 174.33 mmHg 10.15 32.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45773 461
FHH-Chr 17BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 126.83 mmHg 4.56 16.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45777 461
FHH-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 102.7 mmHg 13.12 29.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45782 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 80 129.36 mmHg 3.09 27.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45795 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 10.03 ml/min/g 0.24 0.68 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46633 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 14.82 ml/min/g 0.51 1.93 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46643 461
SHR/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 9.31 ml/min/g 0.45 1.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46647 461
SS-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 19 11.92 ml/min/g 0.53 2.32 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46665 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 10.89 ml/min/g 0.5 1.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46667 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 13 11.23 ml/min/g 0.85 3.05 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46670 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 12 10.15 ml/min/g 0.61 2.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46672 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 14.1 ml/min/g 1.29 4.07 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46676 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 12.68 ml/min/g 0.99 3.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46680 461
Hsd:SD percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 27.26 % 4.93 15.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46963 461
FHH-Chr 10BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 6.23 g/kg 0.41 1.22 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45612 461
FHH-Chr 17BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 20 6.79 g/kg 0.43 1.91 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45616 461
FHH-Chr XBN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 7.02 g/kg 0.36 1.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45625 461
SS-Chr 3BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 6.19 g/kg 0.33 1.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45640 461
SS-Chr 4BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 19 5.42 g/kg 0.18 0.77 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45671 461
FHH-Chr 7BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 6.68 g/kg 0.18 0.56 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45681 461
SS-Chr 16BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 18.35 mmHg 4.49 12.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45689 461
GH/OmrMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 79.44 mmHg 11.13 33.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45692 461
SS-Chr 20BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 13 8.75 IU/g 1.01 3.65 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45694 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 37.33 % 7.04 24.4 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47101 461
FHH-Chr 14BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 49.03 % 9.9 19.8 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47108 461
SS-Chr 14BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 65.55 % 4.53 16.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47109 461
SS-Chr 9BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 47.46 % 4.19 17.77 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47111 461
SS-Chr 6BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 32.47 % 4.43 14.01 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47115 461
FHH-Chr 15BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 48.53 % 8.18 20.03 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47116 461
FHH-Chr 14BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 53.84 % 4.3 10.53 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47118 461
FHH-Chr 16BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 20 post-ischemic value/pre-ischemic value x 100% 57.7 % 3.95 17.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47120 461
FHH-Chr 17BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 post-ischemic value/pre-ischemic value x 100% 53.38 % 3.75 15.47 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47123 461
FHH-Chr 19BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 45.03 % 1.57 4.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47129 461
FHH-Chr 13BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 51.0 % 4.82 13.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47135 461
SS-Chr XBN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 61.26 % 6.5 19.5 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47145 461
SS-Chr 4BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 59.36 % 3.09 13.12 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47151 461
FHH-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 5.52 mmHg 0.46 1.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47184 461
FHH-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.07 mmHg 0.58 1.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47189 461
SHR/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.93 mmHg 0.23 0.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47191 461
FHH-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.12 mmHg 0.36 1.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47205 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 5.65 mmHg 0.42 1.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47216 461
SS-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.3 mmHg 0.25 0.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47218 461
FHH-Chr 15BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 5.63 mmHg 0.47 1.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47236 461
GH/OmrMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.49 mmHg 0.25 0.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47241 461
FHH-Chr 17BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 15 5.29 mmHg 0.22 0.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47243 461
FHH-Chr 17BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 18 5.14 mmHg 0.24 1.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47245 461
SS-Chr 16BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 19 5.49 mmHg 0.27 1.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47251 461
SHR/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 55.05 mmHg 2.35 8.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46414 461
SS-Chr XBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 4.9 mmHg 0.41 1.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47265 461
SS-Chr 1BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 4.81 mmHg 0.39 1.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47266 461
SS-Chr 4BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 18 5.56 mmHg 0.22 0.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47267 461
FHH-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.13 mmHg 0.23 0.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47273 461
BN/NHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 24 5.45 mmHg 0.13 0.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47274 461
Hsd:SD percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 13 post-ischemic value/pre-ischemic value x 100% 50.56 % 3.84 13.85 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48116 461
Crl:CD(SD) time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 870.38 s 51.09 161.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48122 461
SS/JrHsdMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 23.52 % 5.03 15.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48130 461
FHH/EurMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 30.69 % 5.02 13.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48131 461
SS-Chr 16BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 26.52 % 5.15 17.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48132 461
SS/JrHsdMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 34.97 % 6.86 19.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48136 461
GH/OmrMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 35.34 % 5.47 16.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48137 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.2 mmHg 0.29 0.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48169 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 5 4.61 IU/g 1.58 3.53 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45117 461
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 259.58 beats/min 49.97 158.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45139 461
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 12 200.73 beats/min 27.04 93.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45145 461
FHH-Chr 8BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 182.84 beats/min 19.78 52.34 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45149 461
FHH-Chr 1BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 260.6 beats/min 21.86 69.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45163 461
F344/DuCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 56.39 % 7.12 22.52 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47892 461
Hsd:SD time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 13 699.88 s 51.24 184.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47894 461
F344/DuCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.58 mmHg 0.12 0.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48016 461
FHH-Chr 12BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 15 post-ischemic value/pre-ischemic value x 100% 70.13 % 8.72 33.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48280 461
FHH-Chr 6BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 61.5 % 7.11 20.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48284 461
Hsd:SD heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 3 1.37 g 0.05 0.1 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45033 461
GH/OmrMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 44.43 mmHg 6.05 16.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45057 461
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 213.38 beats/min 14.04 34.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45076 461
LEW/Crl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 13.25 ml/min/g 0.64 2.02 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45082 461
F344/DuCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 14.79 ml/min/g 1.06 3.37 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45084 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 12.67 ml/min/g 3.42 9.68 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45099 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 22 5.57 ml/min/g 0.32 1.5 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44782 461
SS-Chr 4BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 8.73 ml/min/g 1.37 5.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44788 461
FHH-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 3.78 ml/min/g 0.3 0.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44791 461
Crl:CD(SD) arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 12.7 ml/min/g 3.58 11.33 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46178 461
LE/BluGill arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 7.44 ml/min/g 0.97 3.06 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46180 461
F344/DuCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 11.01 ml/min/g 0.8 2.41 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46184 461
FHH-Chr XBN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 45.1 % 2.68 7.57 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47077 461
FHH-Chr 8BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 37.15 % 3.66 11.57 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47082 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 50.89 % 6.3 21.83 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47096 461
SS-Chr 19BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 45.36 % 4.91 13.9 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47099 461
SS-Chr 1BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 21.34 mmHg 4.44 11.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45339 461
BN/NHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 22 73.79 mmHg 3.69 17.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45348 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 10.41 IU/g 1.62 4.59 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45364 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 18.67 IU/g 2.75 8.26 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45366 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 18.26 IU/g 3.41 9.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45368 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 14.25 IU/g 2.36 6.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45370 461
SS-Chr 16BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 148.38 mmHg 6.67 22.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45374 461
FHH-Chr XBN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 75.18 % 4.88 13.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48295 461
FHH-Chr 8BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 73.34 % 8.53 22.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48296 461
FHH-Chr 20BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 78.6 % 3.88 11.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48304 461
SS-Chr 18BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 85.06 % 26.69 80.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48309 461
FHH-Chr 1BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 95.53 % 9.46 29.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48310 461
FHH-Chr 4BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 91.74 % 9.9 19.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48311 461
FHH-Chr 5BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 82.81 % 9.42 21.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48330 461
SS-Chr 9BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 91.61 % 12.43 52.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48332 461
SS-Chr 7BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 137.67 % 29.79 98.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48340 461
FHH-Chr 13BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 109.91 % 16.79 47.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48353 461
SS-Chr 3BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 78.73 % 3.86 11.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48355 461
FHH-Chr 9BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 78.97 % 6.1 18.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48370 461
FHH-Chr 7BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 82.31 % 3.97 12.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48376 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 3 0.04 IU/g 0.01 0.02 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48386 461
FHH-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.32 IU/g 0.12 0.33 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47421 461
FHH-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.28 IU/g 0.07 0.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47427 461
FHH-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.54 IU/g 0.2 0.57 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47442 461
FHH-Chr 8BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.51 IU/g 0.09 0.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47456 461
FHH-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 5 183.91 beats/min 21.14 47.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45183 461
SS-Chr 6BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 217.83 beats/min 58.83 166.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45186 461
GH/OmrMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 147.04 beats/min 20.23 63.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45192 461
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 23 227.28 beats/min 6.69 32.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45226 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 1 14.0 mmHg balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45243 461
SS-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 11 238.15 beats/min 15.05 49.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45249 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 50.68 mmHg 8.4 27.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45256 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 46.97 mmHg 6.46 23.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45260 461
FHH-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 22.6 mmHg 5.69 15.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45262 461
SS-Chr 20BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 19 42.28 mmHg 3.14 13.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45272 461
SS-Chr 20BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 21 26.88 mmHg 4.13 18.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45281 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 52.93 mmHg 6.72 22.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45289 461
SS-Chr 14BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 19 40.83 mmHg 4.77 20.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45306 461
GK body weight controlled air oxygen content (5 %) (for 28 days) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. body mass male 16 days 7 333.0 g 6.0 15.87 body weighing method 0.0 0 103002 2784
Crlj:WI blood glucose level controlled air oxygen content (21 %) (for 28 days) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. blood glucose amount male 16 days 6 127.8 mg/dl 7.2 17.64 blood glucose analysis 0.0 0 103003 2784
Crlj:WI blood glucose level controlled air oxygen content (5 %) (for 28 days) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. blood glucose amount male 16 days 7 115.2 mg/dl 7.2 19.05 blood glucose analysis 0.0 0 103004 2784
GK heart right ventricle weight to body weight ratio controlled air oxygen content (21 %) (for 28 days) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart right ventricle mass male 16 days 5 0.4 mg/g 0.04 0.09 post excision weight measurement 0.0 0 103013 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 6 undefined 138.0 mmHg 9.0 22.05 vascular transducer tipped catheter 0.0 0 103015 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 6 undefined 90.0 mmHg 8.0 19.6 vascular transducer tipped catheter 0.0 0 103019 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 96.0 mmHg 8.0 21.17 vascular transducer tipped catheter 0.0 0 103020 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 6 undefined 99.0 mmHg 7.0 17.15 vascular transducer tipped catheter 0.0 0 103023 2784
GK heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 5 395.0 beats/min 17.0 38.01 vascular transducer tipped catheter 0.0 0 103037 2784
GK heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 5 301.0 beats/min 21.0 46.96 vascular transducer tipped catheter 0.0 0 103049 2784
Crlj:WI heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 264.0 beats/min 9.0 23.81 vascular transducer tipped catheter 0.0 0 103052 2784
SS-Chr 11BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 41.78 ml/min 2.27 6.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20274 381
FHH-Chr 9BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 26.4 ml/min 1.48 4.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20290 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 15 0.26 degrees C 0.17 0.67 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20295 381
FHH-Chr 6BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 7 -0.24 degrees C 0.32 0.86 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20298 381
BN/NHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 18 -1.79 degrees C 0.22 0.94 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20389 381
WKY/NCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 20 36.97 degrees C 0.25 1.13 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19997 381
FHH-Chr 18BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 49.66 mmHg 1.67 4.72 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20491 381
LEW/Crl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 12 -6.53 mmHg 0.71 2.47 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20981 381
FHH-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 115.85 % 6.55 21.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53742 381
FHH-Chr XBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 116.26 % 6.75 21.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53753 381
FHH-Chr 8BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 126.94 % 8.47 25.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53759 381
SS-Chr 9BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 50.53 mmHg 0.74 2.47 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20453 381
GH/OmrMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 3 49.32 mmHg 0.79 1.37 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20464 381
FHH/EurMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 10 51.66 mmHg 1.26 3.98 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20478 381
SS-Chr 19BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 0.06 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19819 381
BN/NHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 12 0.07 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19827 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 55.63 ml/min 3.32 12.85 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20194 381
FHH-Chr 6BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 41.31 ml/min 5.25 13.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20197 381
FHH-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 27.96 ml/min 3.12 10.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20218 381
SS-Chr 9BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 35.4 ml/min 2.74 11.28 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20246 381
FHH-Chr 16BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 37.46 ml/min 2.23 8.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20252 381
SS-Chr 11BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 30.86 ml/min 2.17 6.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20271 381
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 95.0 mmHg 6.2 13.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49159 461
SS-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 117.6 % 4.88 17.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53913 381
FHH-Chr 11BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 107.29 % 4.83 14.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53959 381
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 127.71 % 5.44 21.06 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 53968 381
FHH-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 96.04 % 4.33 13.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53970 381
GH/OmrMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 7.5 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20116 381
LEW/Crl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 13 7.52 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18091 381
WKY/NCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 11 7.54 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18097 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.37 ml 0.02 0.07 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14618 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.47 ml 0.04 0.14 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14631 381
FHH-Chr 13BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 105.85 % 7.44 23.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54045 381
SS-Chr 11BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 108.65 % 4.64 13.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54050 381
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 74 109.39 % 2.01 17.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54064 381
FHH-Chr 9BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 91.81 % 5.56 16.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54066 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 138.24 breaths/min 8.02 24.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15377 381
SHR/NCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 5 7.51 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17615 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 -6.88 mmHg 0.7 1.71 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17706 381
Hsd:SD heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 10 427.86 beats/min 13.06 41.31 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15755 381
FHH-Chr 6BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 1 -5.5 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19610 381
SS-Chr 14BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 -5.12 mmHg 0.74 2.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19615 381
FHH-Chr 12BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 11 -4.05 mmHg 0.64 2.12 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19618 381
FHH-Chr 17BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 -5.05 mmHg 0.92 2.6 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19623 381
SHR/NCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 11 -8.56 mmHg 1.18 3.91 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19629 381
FHH-Chr 8BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 -8.05 mmHg 0.57 1.4 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19632 381
SS-Chr 15BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 4 -6.62 mmHg 1.18 2.35 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19637 381
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 104.23 breaths/min 4.64 17.99 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15507 381
SS-Chr 20BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 %change=VE during 2-3 min hypoxia/control during standard conditions 136.9 % 7.5 30.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13682 381
SS-Chr 15BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 146.82 % 8.59 27.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13684 381
FHH-Chr 1BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 18 %change=VE during 2-3 min hypoxia/control during standard conditions 143.73 % 7.23 30.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13695 381
SS-Chr 15BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 5.6 g/dl 0.11 0.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36966 401
FHH-Chr 1BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 15 5.69 g/dl 0.07 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36977 401
FHH-Chr 14BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 4.78 g/dl 0.1 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36993 401
SS-Chr 16BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 19.87 pg 0.13 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 37073 401
FHH-Chr 12BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 12 75.25 mg/dl 1.64 5.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37082 401
FHH-Chr 2BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 59.63 mg/dl 2.93 8.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37084 401
FHH-Chr 10BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 68.25 mg/dl 4.15 11.74 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37090 401
SS-Chr 13BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 11 87.55 mg/dl 2.44 8.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37109 401
FHH-Chr 1BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 9 65.33 mg/dl 2.05 6.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37123 401
SS-Chr 9BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 17 77.06 mg/dl 2.28 9.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37131 401
SS-Chr 9BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 18 73.78 mg/dl 2.68 11.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37134 401
FHH-Chr 13BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 65.7 mg/dl 1.52 4.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37156 401
FHH-Chr 3BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 68.63 mg/dl 2.95 8.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37161 401
SS-Chr 15BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 4 137.78 mmHg 11.93 23.85 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14335 381
FHH-Chr 18BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 8 123.08 mmHg 3.41 9.63 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14346 381
SS-Chr 20BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 11 116.93 mmHg 3.92 13.01 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14348 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 61 123.16 mmHg 2.06 16.07 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14356 381
FHH-Chr 7BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 3 119.96 mmHg 9.79 16.96 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14370 381
SS-Chr XBN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 4 7.49 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17075 381
SS-Chr 4BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.49 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17086 381
BN/NHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 12 7.47 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17091 381
Hsd:SD minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 54.97 ml/min 5.38 12.04 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18962 381
SS/JrHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 56.9 mmHg 0.73 1.8 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18978 381
LE/BluGill serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 6.62 g/dl 0.11 0.35 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36270 401
F344/DuCrl serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 18 154.44 mg/dl 4.36 18.51 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36322 401
LEW/Crl serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 174.1 mg/dl 19.58 61.91 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36325 401
WKY/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 60.23 % 1.66 4.7 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36344 401
SS-Chr 5BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 7 286.86 U/l 9.86 26.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36377 401
FHH-Chr 20BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 405.9 U/l 10.71 33.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36385 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 9 25.78 mmHg 0.57 1.7 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17221 381
SS-Chr 14BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 8 30.94 mmHg 0.75 2.12 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17223 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 10 28.32 mmHg 0.61 1.93 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17243 381
FHH-Chr 8BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 6 29.87 mmHg 1.22 2.98 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17251 381
SS-Chr 13BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 8 26.36 mmHg 0.52 1.47 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17262 381
SS-Chr 11BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 6 26.98 mmHg 0.84 2.06 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17264 381
SS-Chr 4BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 8 25.99 mmHg 0.98 2.77 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17278 381
FHH-Chr 10BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 118.28 % 7.1 22.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13673 381
FHH-Chr 9BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 30.6 ml/min 0.64 1.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18744 381
Hsd:SD mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 16 113.71 mmHg 3.83 15.33 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13664 381
SHR/NCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 157.62 mmHg 8.16 21.6 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14322 381
FHH-Chr 19BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 14 141.8 breaths/min 9.33 34.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18319 381
SS-Chr 11BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 116.27 breaths/min 4.33 13.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18328 381
SS-Chr 11BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 116.23 breaths/min 3.8 11.39 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18331 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 116.6 breaths/min 7.75 32.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18345 381
SS-Chr 15BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.29 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15237 381
FHH-Chr 10BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 133.97 breaths/min 6.95 21.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14787 381
FHH-Chr 10BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.23 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13922 381
FHH-Chr 8BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.28 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13924 381
SS-Chr 20BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 117.63 U/l 4.29 12.14 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37276 401
SS-Chr 20BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 176.75 U/l 4.93 13.94 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37279 401
SS-Chr 12BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 138.91 % 8.94 29.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13701 381
FHH-Chr 1BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 16 %change=VE during 2-3 min hypoxia/control during standard conditions 135.29 % 4.94 19.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13706 381
SS-Chr 10BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 156.82 % 7.5 24.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13709 381
SS-Chr 14BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 153.25 % 12.3 38.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13712 381
FHH-Chr 15BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 145.79 % 8.45 25.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13720 381
SS-Chr 17BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 %change=VE during 2-3 min hypoxia/control during standard conditions 138.75 % 8.47 29.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13723 381
GH/OmrMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 %change=VE during 2-3 min hypoxia/control during standard conditions 129.94 % 7.61 20.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13725 381
SS-Chr 4BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 140.49 % 10.44 34.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13752 381
BN/NHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 %change=VE during 2-3 min hypoxia/control during standard conditions 154.48 % 7.68 32.59 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13760 381
FHH-Chr 7BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 %change=VE during 2-3 min hypoxia/control during standard conditions 141.74 % 7.25 20.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13763 381
FHH-Chr XBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 39.07 ml/min 3.2 10.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18662 381
SS-Chr 20BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 55.9 ml/min 3.0 11.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18673 381
FHH-Chr YBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 37.43 ml/min 1.41 6.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18675 381
SS-Chr 9BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 40.7 ml/min 3.35 13.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18700 381
SS-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 5 406.64 beats/min 9.8 21.92 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17515 381
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 11 400.39 beats/min 11.33 37.57 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17532 381
FHH-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 381.44 beats/min 11.69 30.92 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17540 381
LE/BluGill serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 113.1 mg/dl 4.72 14.93 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36471 401
FHH-Chr 14BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 134.21 breaths/min 6.41 20.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14825 381
SS-Chr 6BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 17 107.14 breaths/min 3.75 15.47 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14828 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 113.45 breaths/min 6.73 26.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14847 381
SS-Chr 16BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 122.79 breaths/min 5.01 18.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14850 381
FHH-Chr 11BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 118.2 breaths/min 3.15 9.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14869 381
FHH-Chr 1BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 18 127.52 breaths/min 6.5 27.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14809 381
FHH-Chr 1BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 16 113.79 breaths/min 5.38 21.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14820 381
FHH-Chr 4BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 0.31 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13941 381
FHH-Chr 15BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.32 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13963 381
SS-Chr 7BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.34 ml 0.04 0.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13969 381
FHH-Chr 19BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 0.31 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13977 381
SS-Chr 16BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 0.33 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13979 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 0.41 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13996 381
SS-Chr 10BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.71 mg/dl 0.11 0.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36653 401
SS-Chr 14BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 17 9.04 mg/dl 0.09 0.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36656 401
FHH-Chr 17BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 6 9.68 mg/dl 0.15 0.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36672 401
SS-Chr 1BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 6 9.28 mg/dl 0.15 0.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36692 401
FHH-Chr 11BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 9 9.24 mg/dl 0.23 0.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36697 401
FHH/EurMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 7 94.71 mg/dl 5.0 13.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36708 401
LEW/Crl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 20 42.82 ml/min 1.82 8.12 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19722 381
SS-Chr 14BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19761 381
SS-Chr 9BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 12 0.05 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19766 381
SS-Chr 5BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 2 0.04 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19777 381
SS-Chr 3BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 2 0.0 null 0.0 0.0 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19796 381
FHH-Chr 12BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 43.75 % 6.29 25.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47062 461
FHH-Chr 6BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 31.39 % 2.09 5.91 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47066 461
SHR/NCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 47.62 % 9.16 34.26 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47074 461
FHH-Chr 20BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 44.31 % 4.08 12.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47083 461
SS-Chr 1BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 39.47 % 2.32 6.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47146 461
FHH-Chr 11BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 38.74 % 3.13 6.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47150 461
FHH-Chr 9BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 49.19 % 5.01 15.04 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47152 461
FHH-Chr 6BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 4.15 mmHg 0.45 1.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47185 461
SHR/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 5.62 mmHg 0.15 0.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47194 461
SS-Chr 15BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.26 mmHg 0.17 0.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47200 461
Crl:CD(SD) percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 144.67 % 8.05 26.69 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19304 381
Hsd:SD serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 5 11.76 mg/dl 0.58 1.31 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36837 401
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 28.08 mmHg 1.15 2.81 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18165 381
SS-Chr 4BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 -53.81 mmHg 5.41 13.25 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19501 381
GH/OmrMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 140.58 breaths/min 10.0 28.27 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18149 381
SS-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 5.78 mmHg 0.16 0.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47229 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 102.49 % 15.94 59.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48285 461
LEW/Crl heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 1.18 g 0.02 0.05 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45035 461
SS-Chr 16BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 63.78 mmHg 3.82 12.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45056 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 6.29 ml/min/g 0.78 1.75 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45094 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 4.46 ml/min/g 0.36 0.94 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45098 461
LEW/Crl time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1099.91 s 37.31 117.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45102 461
Hsd:SD time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 3 1111.09 s 144.75 250.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45110 461
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 13 207.48 beats/min 12.18 43.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45133 461
SS-Chr 6BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 5.14 mmHg 0.26 0.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47235 461
FHH-Chr 3BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 5.31 mmHg 0.4 0.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47250 461
FHH-Chr XBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 160.33 beats/min 11.39 32.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45148 461
SS-Chr 20BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 19 215.48 beats/min 6.6 28.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45150 461
SS-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 17 208.04 beats/min 9.84 40.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45160 461
FHH-Chr 4BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 4 214.26 beats/min 17.57 35.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45164 461
SS-Chr 10BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 211.56 beats/min 12.91 38.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45177 461
FHH-Chr 14BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 4 213.13 beats/min 13.85 27.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45179 461
FHH-Chr XBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 54.66 mmHg 4.52 11.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46413 461
SS-Chr 20BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 19 64.82 mmHg 2.77 12.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46419 461
SS-Chr 6BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.23 IU/g 0.05 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47437 461
FHH-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 0.68 IU/g 0.21 0.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47441 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 74.57 % 10.2 35.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48314 461
FHH-Chr 15BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 73.44 % 8.2 23.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48323 461
SS-Chr 14BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 89.9 % 5.4 20.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48327 461
SS-Chr 3BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 88.25 % 1.92 5.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48350 461
SS-Chr 1BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 67.24 % 7.47 22.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48364 461
SS/JrHsdMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 81.61 % 12.49 49.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48366 461
FHH-Chr 16BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 20 5.7 g/kg 0.18 0.79 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45613 461
FHH-Chr 16BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 20 5.73 g/kg 0.16 0.71 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45626 461
FHH/EurMcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 17 8.05 g/kg 0.41 1.71 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45630 461
SS-Chr 3BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 5.39 g/kg 0.36 1.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45634 461
FHH-Chr 8BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 7.42 g/kg 0.38 1.21 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45639 461
FHH-Chr 18BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 7.53 g/kg 0.26 0.77 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45647 461
SS-Chr 18BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 6.85 g/kg 0.33 0.98 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45655 461
SS-Chr 1BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 11 5.33 g/kg 0.33 1.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45657 461
FHH-Chr 4BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 6.53 g/kg 0.19 0.61 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45661 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 40.86 mmHg 5.98 15.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45686 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 1.71 IU/g 1.07 2.83 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45695 461
GH/OmrMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 9.43 IU/g 1.35 4.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45699 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 15 8.01 IU/g 0.91 3.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45707 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 9.69 IU/g 0.76 2.4 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45711 461
SS-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 101.37 mmHg 6.0 18.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45724 461
SS-Chr 15BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 107.31 mmHg 9.17 29.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45732 461
SS-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 17 132.52 mmHg 3.46 14.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45736 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 8.54 ml/min/g 0.65 1.45 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46635 461
SS-Chr 4BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 17 49.14 mmHg 4.55 18.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45340 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 6 10.58 IU/g 3.03 7.41 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45365 461
SS/JrHsdMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 4 1.6 g 0.02 0.04 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45381 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 5 7.62 ml/min/g 0.77 1.73 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46637 461
SS-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 11.02 ml/min/g 0.65 1.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46648 461
SHR/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 9.67 ml/min/g 0.78 2.94 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46650 461
SS-Chr 15BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 10.67 ml/min/g 0.51 1.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46656 461
SS-Chr 19BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 11.87 ml/min/g 0.62 1.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46675 461
SS-Chr 14BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 16 9.9 ml/min/g 0.61 2.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46685 461
SS-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 19 236.88 beats/min 7.82 34.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45209 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 265.53 beats/min 34.79 130.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45219 461
FHH-Chr 9BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 175.02 beats/min 13.33 39.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45223 461
SS-Chr XBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 218.33 beats/min 14.92 49.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45227 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 306.93 beats/min 30.38 80.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45248 461
FHH-Chr 10BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 37.55 mmHg 3.04 6.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45263 461
FHH-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 47.39 mmHg 4.75 14.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45278 461
FHH-Chr 15BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 27.01 mmHg 7.1 17.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45298 461
FHH-Chr 5BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 36.23 mmHg 6.38 14.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45305 461
FHH-Chr 16BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 19 38.07 mmHg 4.19 18.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45313 461
SS-Chr 16BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 46.24 ml/min 3.31 7.39 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17471 381
F344/DuCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 0.25 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16040 381
FHH-Chr 16BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 19 11.64 ml/min/g 0.56 2.45 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46696 461
SS-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 11.14 ml/min/g 0.67 2.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46702 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 10.41 ml/min/g 1.05 2.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46708 461
SS-Chr 16BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 22 11.45 ml/min/g 0.51 2.39 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46710 461
FHH-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 11.57 ml/min/g 0.53 1.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46712 461
SS-Chr XBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 9.86 ml/min/g 0.46 1.46 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46721 461
FHH-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 13.02 ml/min/g 0.59 1.88 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46729 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 2 133.65 mmHg 12.39 17.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47669 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 119.08 mmHg 9.14 25.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47784 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 11 5.53 ml/min/g 0.42 1.39 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44737 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 6.35 ml/min/g 0.45 1.35 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44742 461
SS-Chr 10BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 6.57 ml/min/g 0.41 1.16 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44758 461
SS-Chr 17BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 6.88 ml/min/g 0.46 1.38 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44760 461
FHH-Chr 17BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 16 5.36 ml/min/g 0.38 1.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44766 461
FHH-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 126.58 mmHg 4.4 13.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45805 461
SS-Chr 16BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 1.44 g 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 45830 461
LEW/Crl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 56.32 % 4.71 13.31 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47889 461
Hsd:SD time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 634.09 s 50.65 160.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47895 461
SS-Chr 16BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 642.67 s 31.42 99.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45838 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 4 169.75 mmHg 12.05 24.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45865 461
FHH-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 7.47 IU/g 1.32 3.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45953 461
FHH-Chr 10BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 4 16.85 IU/g 1.82 3.65 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45965 461
FHH-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 17 19.74 IU/g 2.1 8.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45967 461
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 30.89 IU/g 3.64 10.3 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45971 461
FHH-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 20 26.35 IU/g 1.65 7.38 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45973 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 13 5.82 ml/min/g 0.48 1.72 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46841 461
FHH/EurMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 66.25 % 3.81 8.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48003 461
LEW/Crl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.7 mmHg 0.16 0.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48013 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 3 6.54 mmHg 0.24 0.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48015 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 5.33 ml/min/g 0.36 1.03 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44773 461
SS-Chr YBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 29 5.8 ml/min/g 0.47 2.53 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44783 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 1 3.23 ml/min/g isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 44899 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 3 8.32 ml/min/g 1.98 3.42 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46179 461
LE/BluGill arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 6.64 ml/min/g 0.86 2.58 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46185 461
FHH-Chr 6BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 5.32 x 1000 cells/ul 0.52 1.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41491 401
SS-Chr 20BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 26 6.36 x 1000 cells/ul 0.26 1.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41505 401
SS-Chr 15BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 5.51 x 1000 cells/ul 0.62 1.76 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41507 401
SS-Chr 13BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 12 4.25 x 1000 cells/ul 0.18 0.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41510 401
FHH-Chr 3BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 44.19 ml/min/kg 4.95 14.0 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58063 526
SS/JrHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 98 36.53 ml/min/kg 1.42 14.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58066 526
WKY/NCrl fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58082 526
LE/BluGill fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 13 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58087 526
F344/DuCrl fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 13 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58090 526
FHH-Chr 12BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 0.55 null 0.02 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58098 526
SS-Chr 20BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 28 0.56 null 0.02 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58115 526
FHH-Chr 11BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 9 4.52 x 1000 cells/ul 0.43 1.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41576 401
SS-Chr 3BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 6 19.0 mmol/l 1.84 4.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38322 401
SS-Chr XBN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 11 19.91 mmol/l 0.93 3.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38330 401
SS-Chr 9BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 13 0.35 null 0.04 0.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58150 526
WKY/NCrl mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 32.3 g/dl 0.15 0.44 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42736 401
FHH-Chr 14BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 96.25 U/l 3.6 10.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42801 401
SS-Chr 7BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 11 65.09 U/l 2.77 9.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42820 401
FHH-Chr 19BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 10 101.4 U/l 7.52 23.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42823 401
FHH-Chr 3BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 95.75 U/l 9.61 27.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42834 401
SS/JrHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 94 81.95 U/l 2.52 24.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42837 401
BN/NHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 20 95.1 U/l 6.0 26.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42848 401
FHH-Chr 2BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.39 degrees C 0.15 0.48 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16564 381
FHH-Chr 18BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.06 degrees C 0.2 0.6 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16580 381
SS-Chr 20BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 14 37.73 degrees C 0.11 0.43 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16583 381
FHH-Chr 14BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.35 degrees C 0.22 0.71 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16603 381
BN/NHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 17 4.83 mmol/l 0.16 0.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38145 401
FHH-Chr 7BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 5.56 mmol/l 0.23 0.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38148 401
Crl:CD(SD) red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 9 8.68 x 10E6 cells/ul 0.26 0.78 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38153 401
LE/BluGill serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 106.5 mmol/l 0.48 1.51 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38189 401
FHH-Chr 10BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 19.25 mmol/l 0.73 2.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38260 401
SS-Chr 15BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 19.75 mmol/l 0.53 1.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38265 401
FHH-Chr 8BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.27 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39577 401
SS-Chr 19BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.4 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39596 401
SS-Chr 18BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.39 x 1000 cells/ul 0.08 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39688 401
GH/OmrMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 16 0.21 x 1000 cells/ul 0.03 0.11 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39723 401
FHH/EurMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 49 0.25 x 1000 cells/ul 0.02 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39737 401
SS-Chr 11BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 14 0.44 x 1000 cells/ul 0.06 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39739 401
FHH-Chr 2BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 31.89 g/dl 0.15 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39764 401
FHH-Chr 1BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 13 3.83 x 1000 cells/ul 0.41 1.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41518 401
SS-Chr 14BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 17 5.47 x 1000 cells/ul 0.29 1.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41535 401
SS-Chr 10BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 6.26 x 1000 cells/ul 0.27 0.86 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41543 401
FHH-Chr 16BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 9 3.94 x 1000 cells/ul 0.21 0.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41546 401
SS-Chr 3BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 7 6.12 x 1000 cells/ul 0.44 1.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41559 401
SS-Chr 20BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 69.63 mg/dl 4.4 12.45 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43102 401
Hsd:SD blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 5 0.71 x 1000 cells/ul 0.15 0.33 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41830 401
WKY/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 109.01 mmHg 7.59 21.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49272 461
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 3 114.45 mmHg 11.98 20.75 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49277 461
SS-Chr 13BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 21 967.9 s 27.23 124.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49306 461
FHH-Chr 5BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 955.1 s 25.52 80.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49329 461
SS-Chr 14BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 16 853.88 s 25.32 101.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49331 461
SS-Chr 17BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 958.0 s 25.98 82.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49341 461
FHH-Chr 19BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 1029.5 s 49.44 156.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49351 461
FHH-Chr 19BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 905.2 s 61.51 194.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49355 461
FHH-Chr 13BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 961.6 s 36.28 114.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49358 461
FHH-Chr 11BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 6 900.17 s 42.53 104.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49372 461
FHH-Chr XBN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 32.26 g/dl 0.11 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39773 401
SS-Chr 13BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 32.0 g/dl 0.23 0.8 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39784 401
FHH-Chr 18BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 31.92 g/dl 0.12 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39787 401
FHH-Chr YBN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 32.12 g/dl 0.25 0.74 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39790 401
FHH-Chr YBN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 9 1.38 x 1000 cells/ul 0.1 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43237 401
FHH-Chr 1BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 13 0.99 x 1000 cells/ul 0.12 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43239 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 11 0.61 x 1000 cells/ul 0.07 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43248 401
SS-Chr 10BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 0.79 x 1000 cells/ul 0.07 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43253 401
SS-Chr 10BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.52 x 1000 cells/ul 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43264 401
FHH-Chr 17BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 6 0.45 x 1000 cells/ul 0.12 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43272 401
SS-Chr 3BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 7 0.78 x 1000 cells/ul 0.07 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43280 401
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 85.37 % 3.54 10.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54547 381
SS-Chr 16BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 155.29 % 18.59 49.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54557 381
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 129.06 % 12.5 33.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54560 381
SS-Chr 16BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 6 130.51 % 9.74 23.85 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53534 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 96.69 % 3.08 9.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53547 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 128.24 % 4.63 12.24 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53587 381
GH/OmrMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 137.02 % 4.85 12.82 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53593 381
F344/DuCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 116.96 % 4.5 19.08 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53598 381
Hsd:SD percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 150.44 % 11.99 26.81 stop flow air displacement plethysmography 0 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53601 381
Crl:CD(SD) percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 106.31 % 3.84 12.75 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53606 381
FHH-Chr 17BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 6 136.83 mg/dl 3.79 9.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38576 401
FHH-Chr 3BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 8 142.63 mg/dl 7.14 20.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38584 401
FHH-Chr 13BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 134.3 mg/dl 3.55 11.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38589 401
SS-Chr 16BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 7 102.86 mmol/l 0.59 1.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 38412 401
FHH-Chr XBN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.06 x 1000 cells/ul 0.03 0.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41643 401
FHH-Chr 10BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.03 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41646 401
SS-Chr 15BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41651 401
SS-Chr 10BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.01 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41687 401
SS-Chr 3BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 7 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41703 401
SS-Chr 11BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 15 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41712 401
SS/JrHsdMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 90 0.01 x 1000 cells/ul 0.0 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41714 401
FHH-Chr 8BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 9 147.89 mg/dl 4.71 14.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38535 401
FHH-Chr 18BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 145.1 mg/dl 4.33 13.7 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38540 401
FHH-Chr YBN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 9 138.78 mg/dl 3.58 10.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38543 401
FHH-Chr 4BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 7 167.57 mg/dl 8.77 23.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38546 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 11 138.91 mg/dl 5.24 17.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38554 401
Hsd:SD heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 7 0.33 null 0.03 0.07 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58318 526
Hsd:SD methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 18.56 ml/min/kg 0.73 1.93 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58428 526
SS/JrHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 8 259.9 g 11.7 33.0 whole body digital scale 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58433 526
FHH-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 18 138.3 g 2.1 8.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49492 461
SS-Chr 9BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 167.4 g 2.7 8.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49501 461
FHH-Chr 16BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 20 154.6 g 4.0 17.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49515 461
SS-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 117.1 g 6.8 21.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49536 461
FHH-Chr 18BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 109.7 g 7.8 24.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49549 461
SS-Chr YBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 30 167.6 g 4.5 24.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49555 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 12 130.8 g 3.9 13.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49569 461
SS-Chr 4BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 20 144.8 g 2.3 10.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49573 461
SS-Chr XBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 13 120.7 g 9.8 35.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49582 461
LE/BluGill heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 53.56 mmHg 5.74 17.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49598 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58475 526
FHH-Chr 12BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 12 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58480 526
FHH-Chr 3BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58553 526
SS-Chr 1BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58559 526
SS/JrHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 8 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58561 526
LEW/Crl methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.46 null 0.03 0.08 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58578 526
SS-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 0.88 mg/kg 0.2 0.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58602 526
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 2 123.77 mmHg 11.21 15.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49809 461
FHH-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 102.81 mmHg 5.11 19.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49873 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 103.49 mmHg 5.02 18.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49878 461
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 97.19 mmHg 8.19 21.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49623 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 0.36 IU/g 0.11 0.32 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 49681 461
FHH-Chr 2BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 8 10.59 % 3.35 9.48 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49685 461
SHR/NCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 9 27.29 % 4.54 13.61 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49692 461
FHH-Chr XBN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 8 9.45 % 2.89 8.17 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49694 461
SS-Chr 20BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 20 19.93 % 3.33 14.91 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49700 461
SS-Chr 13BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 19 13.36 % 3.62 15.79 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49710 461
SS-Chr 9BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 18 17.09 % 2.59 10.99 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49735 461
FHH-Chr 15BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 7 4.81 % 1.32 3.49 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49737 461
GH/OmrMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 6.93 % 2.81 8.88 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49742 461
FHH-Chr 3BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 17.88 mmHg 2.75 7.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50060 461
FHH-Chr 7BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 35.8 mmHg 3.26 10.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50078 461
F344/DuCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 115.0 g 2.2 7.0 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50087 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.2 IU/g 0.03 0.08 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50089 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 5 0.31 IU/g 0.1 0.23 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50093 461
FHH/EurMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 1379.23 s 73.12 163.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50099 461
FHH-Chr 12BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 18 1.01 g 0.02 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45390 461
FHH-Chr 6BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 8 1.15 g 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45394 461
SS-Chr 5BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.9 g 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45400 461
SS-Chr 15BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 1.04 g 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45408 461
SS-Chr 13BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 22 0.87 g 0.02 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45412 461
FHH-Chr 18BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 0.82 g 0.06 0.19 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45415 461
SS-Chr 19BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 1.09 g 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45425 461
FHH-Chr 5BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.85 g 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45435 461
FHH-Chr 14BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 0.57 g 0.05 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45446 461
SS-Chr 17BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 0.83 g 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45452 461
SS-Chr 7BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.98 g 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45454 461
FHH/EurMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 17 0.98 g 0.05 0.22 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45456 461
SS-Chr 1BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 35.57 % 6.97 20.91 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49767 461
BN/NHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 23 4.31 % 1.05 5.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49776 461
FHH/EurMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 7 50.14 mmHg 4.97 13.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 49793 461
FHH-Chr 12BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 12 56.97 fl 0.18 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38730 401
FHH-Chr 6BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41857 401
SS-Chr 5BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.15 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41863 401
SS-Chr 5BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 7 0.14 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41866 401
SS-Chr 18BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 9 0.33 mg/dl 0.1 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41882 401
SS-Chr 12BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.13 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41893 401
SS-Chr 6BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41906 401
GH/OmrMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 18 0.2 mg/dl 0.02 0.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41917 401
FHH/EurMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 18 0.18 mg/dl 0.02 0.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41920 401
FHH-Chr 20BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 104.04 mmHg 3.81 11.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49894 461
SS-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 115.87 mmHg 11.06 34.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49911 461
SS-Chr 9BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 18 99.24 mmHg 4.07 17.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49925 461
SS-Chr YBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 28 94.9 mmHg 3.01 15.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49953 461
SS-Chr 1BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 71.24 mmHg 9.95 28.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49955 461
FHH-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 86.38 mmHg 2.82 6.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49961 461
FHH-Chr 10BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 4 18.25 mmHg 6.65 13.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49990 461
SS-Chr 5BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 40.22 mmHg 4.9 14.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49992 461
FHH-Chr XBN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 27.25 mmHg 2.35 6.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49997 461
SS-Chr 20BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.31 mg/kg 0.42 1.12 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58879 526
SS-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 12 1.45 mg/kg 0.3 1.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58913 526
FHH-Chr 11BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 73.6 % 3.9 9.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48829 461
BN/NHsdMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 24 post-ischemic value/pre-ischemic value x 100% 78.22 % 1.72 8.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48833 461
SS-Chr 12BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 59.5 U/l 4.45 12.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40735 401
FHH-Chr 14BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 72.49 mmHg 13.13 32.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48665 461
FHH-Chr 16BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 118.19 mmHg 6.16 20.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48674 461
FHH-Chr 19BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 100.14 mmHg 3.27 9.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48676 461
FHH-Chr 13BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 132.75 mmHg 8.61 19.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48682 461
SS-Chr 11BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 18 113.28 mmHg 4.72 20.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48688 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 119.11 mmHg 4.55 16.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48695 461
FHH-Chr 11BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 113.02 mmHg 4.9 12.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48697 461
SS-Chr 14BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 18 5.99 g/kg 0.21 0.89 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45596 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 11 0.24 IU/g 0.04 0.12 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48707 461
SS-Chr 12BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 78.2 % 6.58 20.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48777 461
SS-Chr 2BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 80.56 % 4.79 15.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48779 461
SS-Chr 6BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 80.17 % 2.8 8.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48789 461
SS-Chr 6BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 55.51 % 9.55 30.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48794 461
FHH-Chr 17BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 96.21 % 12.87 48.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48804 461
SS-Chr 16BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 21 post-ischemic value/pre-ischemic value x 100% 91.59 % 4.43 20.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48810 461
FHH-Chr 13BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 75.9 % 6.04 12.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48814 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 12 1212.42 s 46.74 161.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50246 461
SS-Chr 17BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1164.8 s 28.23 89.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50269 461
SS-Chr 7BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1238.8 s 44.37 140.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50276 461
SS-Chr 3BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 1046.22 s 43.57 130.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50282 461
FHH-Chr 13BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1157.5 s 35.08 110.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50286 461
SS-Chr 4BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 19 1076.95 s 35.94 156.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50301 461
FHH-Chr 9BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1155.8 s 43.87 138.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50307 461
WKY/NCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 20 -0.35 degrees C 0.24 1.05 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19161 381
LE/BluGill absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 0.56 degrees C 0.23 0.84 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19163 381
FHH-Chr 1BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.27 null 0.01 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58759 526
FHH-Chr 14BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.53 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58764 526
SS-Chr 17BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.36 null 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58775 526
FHH-Chr 17BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.49 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58781 526
SS-Chr 7BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 12 0.4 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58783 526
SS-Chr 3BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 15 0.43 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58789 526
SS-Chr 4BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 18 0.3 null 0.01 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58808 526
FHH/EurMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 8 204.8 g 6.7 18.9 whole body digital scale 0 Moms and pups used in studies were fed Dyets 58819 526
WKY/NCrl methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 12.06 ml/min/kg 1.4 4.42 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58841 526
FHH-Chr 6BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 9 59.4 fl 0.22 0.65 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38734 401
SS-Chr 20BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 103.88 mmol/l 1.36 3.83 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40655 401
FHH-Chr 12BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 12 41.75 U/l 2.01 6.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40699 401
FHH-Chr 1BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 15 89.13 U/l 10.4 40.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40729 401
FHH-Chr 4BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 7 41.57 U/l 2.64 6.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40732 401
FHH/EurMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 7 0.19 x 1000 cells/ul 0.06 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40384 401
SS-Chr 20BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 32 177.0 g 2.8 15.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59064 526
FHH-Chr YBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 14 138.1 g 6.5 24.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59075 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 12 221.2 g 4.7 16.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59086 526
SS-Chr 10BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 247.2 g 5.8 18.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59091 526
SS-Chr 1BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 12 179.7 g 7.0 24.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59130 526
Hsd:SD heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 6 0.38 null 0.03 0.08 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 59146 526
FHH-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.15 IU/g 0.06 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47471 461
SS-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 25 252.09 beats/min 7.11 35.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47646 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 94 255.87 beats/min 4.57 44.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47648 461
SS-Chr XBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 250.34 beats/min 6.48 20.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47650 461
SS-Chr 4BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 20 271.8 beats/min 5.0 22.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47652 461
GH/OmrMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 59.35 % 3.41 10.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48506 461
FHH-Chr 12BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 43.85 % 11.32 25.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48512 461
FHH-Chr 6BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 41.69 % 6.69 21.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48515 461
FHH-Chr XBN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 37.31 % 3.89 10.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48523 461
SS-Chr 5BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 22.32 % 4.85 13.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48525 461
SS-Chr 7BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 53.81 % 8.05 24.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48576 461
SS-Chr 3BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 26.21 % 6.91 20.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48582 461
SS-Chr YBN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 24 post-ischemic value/pre-ischemic value x 100% 31.94 % 3.61 17.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48592 461
BN/NHsdMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 22 post-ischemic value/pre-ischemic value x 100% 55.29 % 3.87 18.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48605 461
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 131.2 mmHg 7.44 18.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48638 461
SS-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 87.0 mmHg 3.78 11.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48649 461
FHH-Chr 2BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.56 null 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58720 526
FHH-Chr 10BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.52 null 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58726 526
SS-Chr 5BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.44 null 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58731 526
LE/BluGill blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 9 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40506 401
F344/DuCrl blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 12 0.05 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40509 401
FHH-Chr 2BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.65 g/dl 0.12 0.33 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40542 401
FHH-Chr 8BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.34 g/dl 0.02 0.07 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40551 401
FHH-Chr 20BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.49 g/dl 0.03 0.09 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40556 401
SS-Chr 19BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.77 g/dl 0.05 0.15 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40572 401
SS-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 17 0.29 IU/g 0.13 0.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47475 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 90 0.31 IU/g 0.05 0.45 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47483 461
FHH-Chr 4BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.24 IU/g 0.05 0.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47488 461
SS-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.28 IU/g 0.07 0.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47496 461
SS-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.44 IU/g 0.11 0.35 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47502 461
FHH-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 200.32 beats/min 12.22 36.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47569 461
FHH-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 246.83 beats/min 12.12 36.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47592 461
SS-Chr 9BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 18 262.32 beats/min 10.54 44.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47619 461
FHH-Chr 14BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 213.22 beats/min 17.47 49.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47623 461
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 136.09 % 11.9 33.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53731 381
SS-Chr 19BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 62.93 mmHg 2.41 5.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46437 461
FHH-Chr 15BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 44.27 mmHg 3.66 8.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46445 461
FHH-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 60.47 mmHg 6.08 18.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46447 461
SS-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 19 43.33 mmHg 4.19 18.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46478 461
SS-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 22 51.2 mmHg 2.86 13.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46481 461
SS/JrHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 7 20.0 mmol/l 1.18 3.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39091 401
Crl:CD(SD) serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 9 4.99 mmol/l 0.14 0.41 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39094 401
LE/BluGill serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 9 4.97 mmol/l 0.1 0.3 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39097 401
WKY/NCrl serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.84 mmol/l 0.12 0.34 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39099 401
FHH-Chr 17BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 6 3.92 g/dl 0.03 0.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42279 401
FHH-Chr 16BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 9 3.92 g/dl 0.04 0.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42284 401
FHH-Chr 13BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 4.05 g/dl 0.03 0.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42293 401
SS-Chr 11BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 15 3.94 g/dl 0.07 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42298 401
SS-Chr 1BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 6 3.77 g/dl 0.06 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42301 401
FHH-Chr 11BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 9 3.67 g/dl 0.04 0.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42306 401
FHH-Chr 7BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.83 g/dl 0.07 0.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42315 401
LEW/Crl blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 9 0.85 x 1000 cells/ul 0.09 0.27 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42367 401
FHH/EurMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 7 3.59 g/dl 0.11 0.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42394 401
FHH-Chr 12BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 0.19 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59532 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.15 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59537 526
FHH-Chr 10BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 0.16 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59540 526
SS-Chr 5BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.15 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59545 526
SS-Chr 15BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.16 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59551 526
SS-Chr 13BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 0.15 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59554 526
FHH-Chr 1BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 13 0.14 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59562 526
SS-Chr 11BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 17 62.42 fl 0.4 1.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38807 401
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 57.91 % 1.76 5.27 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38850 401
SS-Chr 20BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 17.71 g/dl 0.4 1.14 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38872 401
SS-Chr 20BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.69 g/dl 0.52 1.48 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38875 401
SS-Chr 17BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 18.13 mmol/l 1.25 3.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42104 401
SS-Chr 3BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 7 21.57 mmol/l 1.17 3.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42118 401
FHH-Chr 13BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 21.1 mmol/l 0.74 2.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42121 401
SS/JrHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 96 17.61 mmol/l 0.37 3.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42129 401
FHH/EurMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 7 5.27 g/dl 0.16 0.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42191 401
SS-Chr 9BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 17 57.21 % 0.41 1.7 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59291 526
SS-Chr 9BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 15 56.17 % 0.5 1.94 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59294 526
SS-Chr 10BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 55.58 % 0.77 2.44 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59297 526
FHH-Chr 17BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 6 49.57 % 1.33 3.26 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59305 526
SS-Chr 20BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.39 mg/dl 0.04 0.11 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37533 401
WKY/NCrl serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.33 mg/dl 0.05 0.15 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37541 401
LEW/Crl plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 21.8 mmol/l 0.68 2.15 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37557 401
LE/BluGill plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 25.5 mmol/l 0.45 1.43 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37560 401
Hsd:SD mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 16 19.41 pg 0.12 0.49 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37565 401
SS/JrHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 9.93 mg/dl 0.37 1.18 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37576 401
FHH-Chr 10BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 10.66 mg/dl 0.35 0.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37593 401
SS-Chr 12BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 10.89 mg/dl 0.28 0.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37615 401
SS-Chr 2BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 8.44 mg/dl 0.28 0.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37617 401
SS-Chr 9BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 17 9.17 mg/dl 0.15 0.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37628 401
SS-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.88 mg/kg 0.39 1.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58951 526
GH/OmrMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 14 2.59 mg/kg 0.68 2.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58955 526
FHH-Chr 12BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 11 3.77 g/dl 0.03 0.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42224 401
SHR/NCrl serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 20 4.04 g/dl 0.03 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42227 401
FHH-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 12 51.08 % 0.54 1.87 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38976 401
FHH-Chr 17BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 6 49.57 % 1.33 3.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39039 401
FHH-Chr 11BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 55.89 % 1.6 4.81 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39064 401
FHH-Chr 10BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 53.31 % 0.37 1.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38990 401
SS-Chr 15BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 56.86 % 0.74 2.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38995 401
FHH-Chr YBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 57.14 % 0.74 2.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39004 401
FHH-Chr 4BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 7 48.36 % 1.24 3.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39009 401
SS-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 55.44 % 0.73 2.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39012 401
SS-Chr 10BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 57.21 % 0.63 1.98 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39020 401
FHH-Chr 16BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 9 52.58 % 0.59 1.77 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39034 401
FHH-Chr 17BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 6 54.32 % 0.44 1.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39037 401
SHR/NCrl serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 20 22.5 mg/dl 0.67 2.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40822 401
SS-Chr 20BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 27 21.78 mg/dl 0.6 3.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40830 401
FHH-Chr YBN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 9 23.56 mg/dl 1.48 4.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40841 401
FHH-Chr 9BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 7 28.14 mg/dl 2.29 6.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40904 401
SHR/NCrl total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 18 4.84 x 1000 cells/ul 0.41 1.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40920 401
FHH-Chr 3BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 5.66 x 1000 cells/ul 0.47 1.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40990 401
SS/JrHsdMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 90 7.0 x 1000 cells/ul 0.18 1.66 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40993 401
WKY/NCrl lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.46 g/kg 0.06 0.19 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57573 526
SS-Chr 20BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 38 12.2 ml/min/kg 0.53 3.25 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57609 526
SS-Chr 12BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 14.73 ml/min/kg 1.15 3.45 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57619 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 11 11.7 ml/min/kg 0.95 3.16 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57622 526
SS-Chr 10BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 17.75 ml/min/kg 1.7 5.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57638 526
SS-Chr 12BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.13 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59568 526
SS-Chr 2BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.16 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59570 526
SS-Chr 9BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 15 0.13 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59584 526
FHH-Chr 17BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.16 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59593 526
FHH-Chr 17BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.16 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59595 526
FHH-Chr 13BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.15 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59606 526
SS-Chr 11BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 17 0.13 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59609 526
SS-Chr 1BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.14 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59617 526
FHH-Chr 11BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.17 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59620 526
BN/NHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 29 0.12 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59626 526
SS-Chr 6BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 9 1.26 g/kg 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59695 526
FHH-Chr 14BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.55 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59698 526
SS-Chr 16BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 16 1.53 g/kg 0.05 0.2 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59712 526
SS-Chr 1BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 12 1.29 g/kg 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59725 526
FHH-Chr 9BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.73 g/kg 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59733 526
FHH-Chr 7BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.57 g/kg 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59739 526
SS/JrHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.06 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Dyets 57755 526
WKY/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.5 mg/kg 0.28 0.84 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57763 526
LE/BluGill dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 12 6.02 mg/kg 1.82 6.29 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57768 526
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 56.96 % 0.99 3.13 microhematocrit tube assay with visual assessment 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57780 526
FHH-Chr 6BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 18.55 ml/min/kg 1.15 3.46 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57788 526
FHH-Chr 12BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 21.34 ml/min/kg 0.88 2.8 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57791 526
F344/DuCrl FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 66.44 ml/min/kg 5.57 22.97 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60131 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 19.32 pg 0.21 0.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42535 401
SS-Chr 15BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 20.68 pg 0.09 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42549 401
SS/JrHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 15.87 ml/min/kg 1.81 4.79 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 57711 526
GH/OmrMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 15 109.27 mmol/l 0.85 3.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39161 401
SS-Chr XBN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 107.9 mmol/l 0.62 1.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39197 401
FHH-Chr XBN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 9.35 x 10E6 cells/ul 0.37 1.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39233 401
SS-Chr 13BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 11 9.42 x 10E6 cells/ul 0.14 0.46 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39249 401
SS-Chr 20BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 4.22 mmol/l 0.21 0.59 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39334 401
Hsd:SD methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.8 null 0.05 0.12 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59744 526
SS-Chr 20BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 33 17.39 g/dl 0.27 1.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37979 401
FHH-Chr 12BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 11 143.09 mmol/l 0.34 1.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39379 401
FHH-Chr 10BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 141.88 mmol/l 0.85 2.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39387 401
SS-Chr 10BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 141.3 mmol/l 0.37 1.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39417 401
Crl:CD(SD) serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 20.25 mg/dl 0.96 2.71 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39513 401
Hsd:SD blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 15 0.41 x 1000 cells/ul 0.08 0.32 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39535 401
SS-Chr 16BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 13 19.61 g/dl 0.31 1.11 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38026 401
FHH-Chr 11BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 16.31 g/dl 0.45 1.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38042 401
FHH-Chr XBN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 4.9 mmol/l 0.31 0.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38062 401
SS-Chr 13BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 12 4.97 mmol/l 0.19 0.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38073 401
FHH-Chr 18BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.17 mmol/l 0.17 0.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38076 401
FHH-Chr 14BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.61 mmol/l 0.36 1.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38097 401
SS-Chr 9BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 12 4.29 mmol/l 0.12 0.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38103 401
LE/BluGill partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 26.99 mmHg 0.76 2.14 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16368 381
SS-Chr 16BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 25.14 mmHg 0.79 2.24 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16449 381
FHH-Chr 15BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 69.53 ml/min/kg 2.37 7.12 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58038 526
SS-Chr 7BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 60.35 ml/min/kg 3.54 12.25 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58049 526
GK mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 143.0 mmHg 3.0 7.94 vascular transducer tipped catheter 0.0 0 103034 2784
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 115.25 breaths/min 4.78 18.5 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15580 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 129.83 breaths/min 11.4 39.49 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15585 381
GH/OmrMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 139.84 breaths/min 5.18 13.7 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15587 381
SS-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 0.44 ml 0.02 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15260 381
SS-Chr 10BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.31 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15262 381
SS-Chr 9BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.4 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15268 381
SS-Chr 6BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 0.45 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15272 381
SS-Chr 10BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.25 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15274 381
SS-Chr 17BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.4 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15276 381
SS-Chr 7BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.31 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15279 381
SS-Chr 16BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 0.3 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15289 381
SS-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.28 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15295 381
SS-Chr YBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 0.42 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15300 381
SS-Chr 4BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.34 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15305 381
FHH-Chr 7BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.31 ml 0.04 0.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15311 381
FHH-Chr 7BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.21 ml 0.04 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15316 381
FHH-Chr 10BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.2 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15232 381
SS-Chr 15BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 0.27 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15236 381
FHH-Chr YBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 0.26 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15246 381
FHH-Chr 1BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 16 0.32 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15259 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.4 ml 0.02 0.07 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14619 381
GH/OmrMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.34 ml 0.02 0.06 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14621 381
SS-Chr 16BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 137.02 breaths/min 7.19 19.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15373 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 110.0 breaths/min 5.96 15.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15375 381
SS-Chr 16BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 7 130.71 breaths/min 4.68 12.39 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15376 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.28 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13647 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.36 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13654 381
SS/JrHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 15 -0.23 degrees C 0.17 0.66 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14130 381
GH/OmrMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 8 -1.09 degrees C 0.28 0.78 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14133 381
SS/JrHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 %change=VE during 2-3 min hypoxia/control during standard conditions 142.6 % 5.82 22.53 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14140 381
GH/OmrMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 %change=VE during 2-3 min hypoxia/control during standard conditions 140.08 % 7.97 22.56 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14143 381
FHH-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 19 116.49 breaths/min 4.28 18.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14779 381
SS-Chr 10BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 105.02 mmHg 4.12 12.37 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14303 381
SS-Chr 14BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 124.55 mmHg 3.93 10.4 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14306 381
SS-Chr 7BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 107.76 mmHg 3.41 10.22 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14318 381
FHH-Chr 17BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 136.03 mmHg 9.09 27.28 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14320 381
SS-Chr 3BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 5 127.74 mmHg 7.4 16.55 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14336 381
SS-Chr 16BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 118.55 mmHg 2.03 6.1 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14339 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 10 122.71 mmHg 2.46 7.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14361 381
FHH-Chr 6BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 104.75 % 4.75 15.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53870 381
FHH-Chr 20BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 114.4 % 8.7 26.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53892 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 23 117.29 % 5.01 24.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53895 381
FHH-Chr YBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 104.07 % 3.92 17.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53901 381
SS-Chr 19BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 104.82 % 3.83 10.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53907 381
SS-Chr 6BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 108.61 % 4.23 17.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53919 381
SS-Chr 14BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 113.05 % 3.16 10.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53922 381
FHH-Chr 17BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 102.65 % 2.59 7.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53933 381
SS-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 113.73 % 4.34 15.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53941 381
FHH-Chr 13BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 116.74 % 5.93 18.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53944 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 117.95 % 3.6 13.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53953 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 118.68 % 3.63 12.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53956 381
SS-Chr 4BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 112.65 % 4.16 16.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53960 381
FHH-Chr 9BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 97.64 % 2.87 9.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53961 381
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 74 114.78 % 1.91 16.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53963 381
FHH-Chr 7BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 115.08 % 6.23 17.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53966 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 98.36 % 5.58 23.67 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53972 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 20 89.15 % 3.07 13.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53974 381
GH/OmrMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 102.95 % 5.97 15.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53978 381
SS-Chr 15BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 100.61 % 5.46 21.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53990 381
FHH-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 105.57 % 5.74 19.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53999 381
FHH-Chr YBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 100.31 % 3.22 14.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54002 381
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 109.83 % 3.47 14.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54006 381
SS-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 103.27 % 5.67 18.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54009 381
SS-Chr 19BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 114.96 % 6.31 18.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54010 381
SS-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 103.24 % 5.3 18.37 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54011 381
SS-Chr 5BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 118.23 % 8.27 26.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53746 381
SS-Chr 15BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 135.01 % 9.64 30.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53758 381
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 23 107.67 % 2.68 12.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53763 381
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 119.67 % 6.41 27.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53765 381
FHH-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 117.0 % 9.15 30.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53766 381
FHH-Chr 4BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 122.13 % 11.94 41.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53774 381
SS-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 115.01 % 2.92 10.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53781 381
FHH-Chr 15BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 125.44 % 13.37 40.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53793 381
SS-Chr 16BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 130.97 % 5.46 20.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53807 381
SS-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 123.77 % 9.64 31.98 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53814 381
SS-Chr 11BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 129.67 % 6.77 20.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53817 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 122.76 % 5.75 19.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53819 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 119.35 % 2.9 11.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53821 381
SS-Chr 4BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 114.22 % 8.76 29.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53825 381
FHH-Chr 11BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 109.04 % 5.14 15.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53827 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 9 0.06 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19759 381
FHH-Chr 6BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 1 0.01 null automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19760 381
SS-Chr 6BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 11 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19762 381
FHH-Chr 19BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 0.03 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19786 381
FHH-Chr 20BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 0.03 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19797 381
FHH-Chr 20BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19801 381
SS/JrHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 0.05 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19815 381
FHH-Chr 11BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 5 0.05 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19821 381
SS-Chr 2BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19824 381
BN/NHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19828 381
SS-Chr XBN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 0.03 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19829 381
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 44.12 ml/min 4.37 13.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20698 381
SS-Chr 16BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 56.71 ml/min 4.74 12.53 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20704 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 29.44 ml/min 1.78 5.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20707 381
SS-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 32.36 ml/min 2.01 6.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18724 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 74 56.02 ml/min 1.81 15.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18730 381
FHH-Chr 7BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 37.21 ml/min 5.52 18.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18740 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 23 32.31 ml/min 1.43 6.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18741 381
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 6 431.15 beats/min 29.19 71.49 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18759 381
GH/OmrMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18787 381
F344/DuCrl mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 14 57.48 fl 0.26 0.98 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36288 401
LEW/Crl serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 174.5 mg/dl 14.42 45.6 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36320 401
Crl:CD(SD) serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 9 156.56 mg/dl 11.25 33.74 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36323 401
LE/BluGill serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 9 151.78 mg/dl 5.55 16.66 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36324 401
WKY/NCrl serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 9 188.56 mg/dl 14.73 44.19 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36326 401
SS/JrHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 4 140.0 mmol/l 1.68 3.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36334 401
LEW/Crl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 61.88 % 1.0 2.84 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36345 401
WKY/NCrl mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 19.36 pg 0.15 0.43 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36354 401
F344/DuCrl mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 14 18.61 pg 0.1 0.37 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36357 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 14 179.79 U/l 17.52 65.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36365 401
FHH-Chr 10BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 385.75 U/l 33.59 95.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36372 401
FHH-Chr XBN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 443.25 U/l 22.67 64.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36375 401
SHR/NCrl serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 17 198.0 U/l 5.4 22.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36376 401
FHH-Chr 18BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 426.2 U/l 8.94 28.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36387 401
FHH-Chr YBN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 9 437.11 U/l 13.39 40.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36392 401
FHH-Chr 4BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 303.0 U/l 12.11 34.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36395 401
FHH-Chr 1BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 9 269.0 U/l 8.94 26.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36405 401
SS-Chr 6BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 9 133.22 U/l 4.61 13.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36412 401
FHH-Chr 5BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 457.13 U/l 34.7 98.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36414 401
SS-Chr 17BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 232.5 U/l 32.13 90.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36421 401
FHH-Chr 16BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 273.88 U/l 10.11 28.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36422 401
FHH-Chr 16BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 9 376.78 U/l 10.56 31.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36430 401
FHH/EurMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 18 268.28 U/l 12.37 52.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36431 401
SS-Chr 11BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 15 214.67 U/l 9.27 35.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36444 401
SS-Chr XBN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 11 189.45 U/l 12.91 42.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36448 401
SS-Chr 4BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 29 226.76 U/l 5.69 30.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36450 401
FHH-Chr 9BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 7 520.86 U/l 27.85 73.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36455 401
Crl:CD(SD) serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 9 62.33 mg/dl 5.12 15.37 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36466 401
SS-Chr 5BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 5.71 g/dl 0.07 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36957 401
SS-Chr 15BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.64 g/dl 0.11 0.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36965 401
Crl:CD(SD) partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 5 51.86 mmHg 0.35 0.77 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17008 381
F344/DuCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 53.67 mmHg 1.36 3.85 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17009 381
Crl:CD(SD) partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 54.5 mmHg 1.38 3.65 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17010 381
FHH-Chr 12BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 12 7.48 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17020 381
FHH-Chr 6BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 1 7.4 null automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17023 381
GH/OmrMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 7.52 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17043 381
SS-Chr 5BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 2 7.5 null 0.03 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17046 381
SS-Chr 3BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.5 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17054 381
FHH-Chr 14BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 172.82 breaths/min 12.66 40.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18307 381
SS-Chr 17BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 119.64 breaths/min 7.41 23.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18313 381
SS-Chr 16BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 141.08 breaths/min 5.33 19.23 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18324 381
FHH-Chr 13BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 138.39 breaths/min 5.0 16.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18326 381
Crl:CD(SD) minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 43.51 ml/min 3.51 11.65 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18966 381
LEW/Crl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 20 41.01 ml/min 2.04 9.13 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18968 381
SS/JrHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 56.83 mmHg 0.82 2.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18972 381
SS-Chr 16BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 4 59.11 mmHg 1.83 3.67 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18974 381
LEW/Crl serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 5.58 g/dl 0.29 0.93 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36262 401
LEW/Crl serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.43 g/dl 0.12 0.37 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36267 401
SS/JrHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 %change=VE during7-9 min hypoxia/control during standard conditions 127.69 % 6.86 26.56 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18368 381
GH/OmrMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 %change=VE during7-9 min hypoxia/control during standard conditions 142.36 % 11.33 32.05 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18371 381
SS-Chr 16BN/Mcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 %change=VE during7-9 min hypoxia/control during standard conditions 133.83 % 7.44 16.65 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18372 381
SS-Chr 18BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.82 g/dl 0.14 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36976 401
FHH-Chr 4BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 7 5.03 g/dl 0.12 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36980 401
SS-Chr 12BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 5.26 g/dl 0.16 0.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36983 401
SS-Chr 10BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 10 5.45 g/dl 0.08 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36991 401
FHH-Chr 5BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 5.05 g/dl 0.11 0.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36992 401
SS-Chr 14BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 17 5.92 g/dl 0.07 0.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36994 401
SS-Chr 10BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 5.65 g/dl 0.06 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37002 401
FHH-Chr 17BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 6 5.05 g/dl 0.06 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37010 401
FHH-Chr 16BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 9 5.64 g/dl 0.06 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37013 401
FHH-Chr 3BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 4.9 g/dl 0.13 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37016 401
FHH-Chr 13BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 5.3 g/dl 0.05 0.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37021 401
SS-Chr YBN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 20 6.43 g/dl 0.05 0.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37028 401
SS-Chr 4BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 29 5.81 g/dl 0.09 0.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37033 401
FHH-Chr 9BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 7 4.47 g/dl 0.16 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37038 401
FHH/EurMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 7 11.71 mmol/l 1.11 2.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37046 401
SS-Chr 16BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 7 19.29 mmol/l 0.42 1.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37048 401
FHH-Chr 6BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 83.0 mg/dl 1.58 5.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37085 401
SS-Chr 5BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 68.0 mg/dl 2.49 7.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37092 401
FHH-Chr 10BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 74.25 mg/dl 2.29 6.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37096 401
FHH-Chr XBN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 7 70.0 mg/dl 2.27 6.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37097 401
FHH-Chr YBN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 9 70.22 mg/dl 2.0 6.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37110 401
SS-Chr 6BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 9 80.0 mg/dl 3.48 10.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37130 401
FHH-Chr 5BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 71.63 mg/dl 1.32 3.74 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37132 401
SS-Chr 4BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 29 83.83 mg/dl 1.2 6.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37168 401
SS-Chr XBN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 84.8 mg/dl 2.25 7.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37177 401
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 110.12 breaths/min 3.55 15.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14811 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 100.74 breaths/min 3.97 12.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14813 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 14 123.38 breaths/min 5.25 19.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14818 381
FHH-Chr 5BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 144.12 breaths/min 16.43 51.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14824 381
SS-Chr 9BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 17 106.44 breaths/min 4.03 16.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14832 381
SS-Chr 10BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 115.26 breaths/min 6.78 21.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14835 381
GH/OmrMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 6 122.26 breaths/min 14.96 36.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14844 381
FHH-Chr 16BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 140.08 breaths/min 4.9 14.71 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14846 381
FHH-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 125.33 breaths/min 6.75 21.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14849 381
SS-Chr 11BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 114.76 breaths/min 4.72 14.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14857 381
SS-Chr 11BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 112.93 breaths/min 3.73 11.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14860 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 74 125.74 breaths/min 2.83 24.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14862 381
SS-Chr 1BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 151.87 breaths/min 3.03 9.59 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14863 381
FHH-Chr 11BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 119.06 breaths/min 6.9 19.51 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14868 381
SS-Chr 16BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 0.37 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14901 381
SS/JrHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 132.16 mmHg 5.14 13.61 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14416 381
FHH-Chr 10BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 120.95 breaths/min 4.12 13.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14793 381
SS-Chr 20BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 14 134.59 breaths/min 3.22 12.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14805 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 112.44 breaths/min 5.18 20.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14808 381
SS-Chr 6BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 102.5 % 3.05 10.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54025 381
SS-Chr 10BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 108.96 % 4.62 14.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54027 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 106.26 % 6.98 22.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54037 381
FHH-Chr 19BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 92.36 % 6.0 22.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54038 381
SS-Chr 16BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 109.37 % 2.83 10.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54044 381
FHH-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 107.61 % 5.07 16.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54049 381
SS-Chr YBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 111.37 % 3.96 17.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54051 381
FHH-Chr 11BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 104.54 % 6.16 17.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54059 381
FHH-Chr 9BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 88.23 % 6.39 20.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54062 381
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 98.48 % 7.58 16.96 stop flow air displacement plethysmography 0 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54197 381
Crl:CD(SD) percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 96.12 % 1.49 5.36 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54198 381
LE/BluGill percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 93.56 % 3.26 11.74 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54201 381
FHH-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.24 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13915 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 0.33 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13920 381
FHH-Chr 20BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.28 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13929 381
SS-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 0.36 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13946 381
SS-Chr 6BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 0.41 ml 0.02 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13957 381
FHH-Chr 16BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 0.28 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13967 381
FHH-Chr 17BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.26 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13972 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 0.36 ml 0.02 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13976 381
FHH-Chr 13BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.25 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13984 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 49 0.3 ml 0.01 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13987 381
FHH-Chr 11BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.37 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13997 381
FHH-Chr 11BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.36 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13998 381
F344/DuCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 0.32 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14011 381
SS-Chr 18BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 144.31 % 6.64 19.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14030 381
SS-Chr 16BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 %change=VE during 2-3 min hypoxia/control during standard conditions 181.93 % 15.74 41.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14033 381
SS-Chr 6BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 11 28.01 mmHg 0.79 2.62 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17219 381
FHH-Chr 6BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 1 32.55 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17222 381
FHH-Chr 17BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 8 28.59 mmHg 1.08 3.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17231 381
SHR/NCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 6 28.66 mmHg 0.69 1.69 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17233 381
FHH-Chr 17BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 8 29.95 mmHg 0.79 2.25 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17235 381
SS-Chr 5BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 2 26.1 mmHg 0.5 0.71 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17238 381
SS-Chr 16BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 9 26.38 mmHg 1.84 5.53 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17249 381
FHH-Chr 13BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 6 28.78 mmHg 1.56 3.83 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17250 381
SS-Chr 13BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 7 26.53 mmHg 1.11 2.94 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17255 381
SS-Chr 20BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 10 27.22 mmHg 0.99 3.12 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17258 381
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 10 26.17 mmHg 1.75 5.53 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17265 381
FHH-Chr 4BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 2 28.25 mmHg 2.45 3.46 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17272 381
SS-Chr 19BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 1 27.8 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17279 381
FHH-Chr 7BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 3 28.28 mmHg 1.37 2.38 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17280 381
FHH-Chr 14BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 138.21 % 7.13 22.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13711 381
SS-Chr 7BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 160.0 % 12.48 37.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13726 381
FHH-Chr 16BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 149.61 % 7.65 22.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13732 381
FHH-Chr 3BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 174.34 % 13.15 41.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13735 381
SS-Chr 1BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 144.0 % 9.33 29.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13751 381
LEW/Crl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 20 %change=VE during7-9 min hypoxia/control during standard conditions 133.06 % 6.62 29.59 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17339 381
FHH-Chr 2BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 137.56 % 8.88 28.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13672 381
FHH-Chr 10BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 162.25 % 13.64 43.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13679 381
FHH-Chr 8BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 148.01 % 16.04 53.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13681 381
FHH-Chr 8BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 141.35 % 16.26 48.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13685 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 155.51 % 7.16 22.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13699 381
SS-Chr 19BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 %change=VE during 2-3 min hypoxia/control during standard conditions 135.44 % 13.4 37.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13700 381
SS-Chr 2BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 %change=VE during 2-3 min hypoxia/control during standard conditions 132.84 % 6.34 21.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13703 381
SS-Chr 20BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 10 7.53 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17066 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.52 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17082 381
FHH-Chr 11BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 5 7.49 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17085 381
SS-Chr XBN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.52 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17093 381
F344/NHsd heart right ventricle weight to left ventricle plus septum weight ratio controlled air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 heart right ventricle mass male 105 days 23 median 0.41 g/g post excision weight measurement 0 11569 102
WKY/NCruk body weight controlled air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 body mass male 105 days 28 median 270.0 g body weighing method 0 11574 102
WKY/NCruk heart left ventricle wet weight controlled air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 heart left ventricle mass male 105 days 28 median 0.77 g post excision weight measurement 0 11576 102
Crl:CD(SD) respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 149.87 breaths/min 6.13 22.11 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17558 381
Crl:CD(SD) respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 143.38 breaths/min 7.28 24.15 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17560 381
LE/BluGill respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 162.35 breaths/min 6.76 21.37 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17561 381
LEW/Crl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 20 135.76 breaths/min 6.24 27.93 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17562 381
WKY/NCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 20 159.61 breaths/min 5.75 25.73 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17563 381
LE/BluGill respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 168.56 breaths/min 10.44 37.64 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17565 381
LE/BluGill absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 -48.21 mmHg 3.33 8.82 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20691 381
WKY/NCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 10 -39.28 mmHg 3.39 10.71 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20693 381
FHH/EurMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 8 -0.26 degrees C 0.28 0.8 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19579 381
SS-Chr 10BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 -6.21 mmHg 0.74 2.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19608 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 9 -5.01 mmHg 0.58 1.74 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19609 381
SS-Chr 14BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 -7.77 mmHg 0.38 0.93 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19611 381
SS-Chr 9BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 12 -7.02 mmHg 0.85 2.95 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19616 381
SS-Chr 10BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 4 -8.12 mmHg 0.82 1.65 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19619 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 10 -8.18 mmHg 0.79 2.51 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19635 381
SS-Chr 16BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 10 -7.23 mmHg 0.94 2.98 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19636 381
SS-Chr 3BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 4 -5.0 mmHg 1.05 2.09 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19638 381
FHH-Chr 8BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 -6.43 mmHg 0.78 1.9 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19643 381
SS-Chr 3BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 2 -6.65 mmHg 1.05 1.48 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19644 381
FHH-Chr 13BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 10 -5.91 mmHg 1.3 4.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19646 381
FHH/EurMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.5 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17611 381
SS-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 135.3 breaths/min 8.07 24.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17682 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 14 127.67 breaths/min 6.34 23.71 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17683 381
SS-Chr 16BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 -6.36 mmHg 0.75 2.13 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17709 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 -7.15 mmHg 1.45 3.83 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17715 381
SS-Chr 16BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 6 37.95 degrees C 0.2 0.5 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17722 381
GH/OmrMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 7 37.14 degrees C 0.16 0.43 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17725 381
LE/BluGill blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.49 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18099 381
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 441.62 beats/min 9.52 25.2 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18105 381
SS-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 444.03 beats/min 9.59 25.39 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18106 381
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 431.68 beats/min 10.13 30.4 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18107 381
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 4 349.4 beats/min 28.52 57.04 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18108 381
FHH/EurMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypoxia/control during standard conditions 130.54 % 9.23 29.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17914 381
SS-Chr 16BN/Mcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 %change=VE during7-9 min hypoxia/control during standard conditions 166.49 % 13.86 36.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17918 381
BN/NHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during7-9 min hypoxia/control during standard conditions 113.63 % 4.18 12.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17920 381
SS-Chr 16BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 -51.78 mmHg 2.16 5.28 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17940 381
BN/NHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 -51.1 mmHg 2.72 7.19 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17943 381
Hsd:SD absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 1 -50.4 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20686 381
SS-Chr 11BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 -6.79 mmHg 0.72 1.76 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19652 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 -7.24 mmHg 0.7 1.71 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19661 381
SS-Chr 4BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 4 -6.07 mmHg 1.05 2.11 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19662 381
SS/JrHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 9 -6.63 mmHg 0.8 2.4 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19663 381
FHH-Chr 11BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 2 -7.25 mmHg 6.4 9.05 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19665 381
SS-Chr 12BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 3 -6.75 mmHg 2.74 4.75 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19668 381
FHH-Chr 7BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 2 -5.0 mmHg 1.1 1.56 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19679 381
SS-Chr 16BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 4 -41.96 mmHg 2.39 4.78 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18641 381
FHH-Chr 10BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 28.65 ml/min 2.9 9.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18655 381
SS-Chr 15BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 35.96 ml/min 3.46 10.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18666 381
FHH-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 27.76 ml/min 1.78 5.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18672 381
FHH-Chr 1BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 18 47.81 ml/min 2.7 11.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18677 381
FHH-Chr 4BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 41.63 ml/min 3.87 13.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18680 381
SS-Chr 19BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 54.94 ml/min 7.34 20.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18682 381
FHH-Chr 1BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 16 40.16 ml/min 2.01 8.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18688 381
FHH-Chr 15BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 44.14 ml/min 3.08 9.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18690 381
FHH-Chr 14BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 35.66 ml/min 3.32 10.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18693 381
SS-Chr 6BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 41.67 ml/min 1.84 7.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18696 381
SS-Chr 14BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 42.68 ml/min 2.09 7.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18699 381
SS-Chr 6BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 59.04 ml/min 3.85 13.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18701 381
SS/JrHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 9 6.2 g/dl 0.16 0.47 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37407 401
Hsd:SD serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 18 6.63 g/dl 0.12 0.51 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37410 401
Crl:CD(SD) serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 9 89.78 U/l 3.79 11.38 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37424 401
SS/JrHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 9 223.56 U/l 19.01 57.04 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37277 401
SS/JrHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 132.4 U/l 4.75 15.01 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37281 401
Hsd:SD mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 5 20.48 pg 0.82 1.84 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36568 401
Hsd:SD serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 18 18.17 mmol/l 0.44 1.86 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36589 401
SS/JrHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 19.0 mmol/l 0.58 1.83 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36590 401
SS/JrHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 9 143.56 mmol/l 0.38 1.13 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36592 401
FHH-Chr 2BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.21 mg/dl 0.07 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36616 401
FHH-Chr 16BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 39.13 ml/min 2.21 8.28 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18706 381
GH/OmrMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 46.43 ml/min 4.95 13.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18707 381
SS-Chr 17BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 36.5 ml/min 3.8 12.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18710 381
FHH-Chr 17BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 32.09 ml/min 2.73 8.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18711 381
FHH-Chr 19BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 41.68 ml/min 1.81 6.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18716 381
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 17 411.57 beats/min 13.0 53.6 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17475 381
SS-Chr 6BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 11 421.09 beats/min 14.92 49.48 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17486 381
FHH-Chr 17BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 425.96 beats/min 24.66 73.99 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17493 381
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 2 369.86 beats/min 16.67 23.57 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17501 381
SS-Chr 20BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 15 403.88 beats/min 17.75 68.76 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17504 381
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 11 420.82 beats/min 18.01 59.74 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17506 381
SS-Chr 15BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 4 443.27 beats/min 22.66 45.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17510 381
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 19 402.94 beats/min 12.75 55.56 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17524 381
FHH-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 6 771.68 beats/min 175.59 430.1 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17536 381
SS-Chr 19BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 4 437.1 beats/min 20.79 41.58 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17538 381
WKY/NCrl heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 7.5 g/kg 0.39 1.17 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49143 461
LE/BluGill respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 163.97 breaths/min 7.29 23.04 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18211 381
SS-Chr 18BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 7 38.04 degrees C 0.14 0.36 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18233 381
BN/NHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 8 37.03 degrees C 0.2 0.56 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18237 381
SS-Chr 5BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 155.27 breaths/min 13.8 43.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18260 381
SS-Chr 20BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 17 128.62 breaths/min 3.18 13.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18267 381
FHH-Chr 20BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 137.36 breaths/min 4.44 13.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18271 381
FHH-Chr 20BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 146.72 breaths/min 16.37 46.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18274 381
SS/JrHsdMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 904.99 s 89.21 252.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48928 461
LE/BluGill heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 9 17.51 % 7.34 22.01 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49039 461
SS-Chr 20BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 -43.7 mmHg 3.54 10.61 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19464 381
FHH-Chr 13BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 -40.3 mmHg 3.63 8.9 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19473 381
FHH-Chr 20BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 -41.8 mmHg 3.3 8.72 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19480 381
FHH-Chr 18BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 -44.32 mmHg 1.81 5.13 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19482 381
FHH-Chr 1BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 9 -52.62 mmHg 2.5 7.49 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19491 381
SS-Chr 4BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 4 -45.17 mmHg 3.82 7.64 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19493 381
FHH-Chr 11BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 5 -48.66 mmHg 3.86 8.62 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19500 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 7 -43.59 mmHg 2.46 6.52 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19505 381
SS-Chr 2BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 -47.67 mmHg 1.24 4.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19511 381
SS-Chr 9BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 12 57.57 mmHg 2.0 6.92 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20457 381
SS-Chr 10BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 4 55.5 mmHg 1.22 2.44 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20460 381
FHH-Chr 16BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 4 52.74 mmHg 1.64 3.27 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20462 381
SS-Chr 17BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 2 64.85 mmHg 0.05 0.07 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20466 381
FHH-Chr 17BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 53.36 mmHg 2.14 6.06 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20469 381
SS-Chr 5BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 1 66.4 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20473 381
SS-Chr 20BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 10 53.5 mmHg 0.62 1.97 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20476 381
SS-Chr 15BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 58.78 mmHg 4.71 11.53 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20480 381
SS-Chr 13BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 55.98 mmHg 1.51 3.98 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20490 381
FHH-Chr 1BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 55.07 mmHg 1.17 3.89 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20503 381
SS-Chr 18BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 54.09 mmHg 1.49 3.93 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20504 381
FHH-Chr 11BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 2 56.25 mmHg 2.75 3.89 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20508 381
SS-Chr 12BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 60.6 mmHg 4.41 7.64 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20511 381
SS-Chr 2BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 56.06 mmHg 1.74 5.22 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20516 381
BN/NHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 53.58 mmHg 1.29 3.65 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20520 381
FHH-Chr 5BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 150.88 breaths/min 10.95 34.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18295 381
FHH-Chr 14BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 169.41 breaths/min 8.23 26.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18296 381
FHH-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 26.0 ml/min 0.89 3.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20193 381
FHH-Chr 6BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 43.66 ml/min 5.57 18.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20196 381
FHH-Chr XBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 32.47 ml/min 2.74 8.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20208 381
FHH-Chr 20BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 35.73 ml/min 3.8 10.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20217 381
SS-Chr 10BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 41.81 ml/min 3.26 10.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20237 381
FHH-Chr 5BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 40.38 ml/min 3.35 10.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20244 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 41.29 ml/min 3.2 12.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20261 381
SS-Chr 4BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 32.59 ml/min 1.84 7.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20284 381
FHH-Chr 10BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.43 degrees C 0.16 0.51 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20302 381
FHH/EurMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 4 -8.16 mmHg 2.47 4.94 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19328 381
SS-Chr 9BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 -48.86 mmHg 2.83 9.38 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19442 381
SS-Chr 14BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 -42.27 mmHg 1.55 4.39 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19444 381
SS-Chr 7BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 7 -45.89 mmHg 3.9 10.32 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19451 381
SS-Chr 7BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 -49.09 mmHg 5.14 13.61 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19459 381
FHH-Chr 8BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 -43.71 mmHg 4.12 10.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19463 381
FHH-Chr 20BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.94 mg/dl 0.11 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36630 401
FHH-Chr 20BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.83 mg/dl 0.09 0.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36633 401
SS-Chr 18BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 9 9.09 mg/dl 0.1 0.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36641 401
SS-Chr 12BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.44 mg/dl 0.09 0.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36649 401
SS-Chr 2BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 12 9.47 mg/dl 0.11 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36651 401
SS-Chr 9BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 17 9.27 mg/dl 0.13 0.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36658 401
SS-Chr 17BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.74 mg/dl 0.14 0.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36671 401
FHH-Chr 19BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.29 mg/dl 0.19 0.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36677 401
FHH-Chr 13BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.92 mg/dl 0.13 0.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36684 401
SS-Chr XBN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.07 mg/dl 0.1 0.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36704 401
WKY/NCrl serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 9.86 mg/dl 0.54 1.7 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36715 401
LEW/Crl serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 9.59 mg/dl 0.38 1.21 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36721 401
Hsd:SD serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 5 236.6 mg/dl 27.35 61.16 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36739 401
FHH-Chr 10BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 0.17 degrees C 0.1 0.31 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20308 381
SS-Chr 13BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 -0.69 degrees C 0.29 0.92 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20316 381
FHH-Chr 18BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 0.46 degrees C 0.3 0.9 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20317 381
FHH-Chr 4BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 0.33 degrees C 0.11 0.41 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20325 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 -0.34 degrees C 0.28 0.87 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20328 381
SS-Chr 12BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 0.07 degrees C 0.14 0.47 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20330 381
FHH-Chr 1BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 15 -0.11 degrees C 0.15 0.58 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20335 381
SS-Chr 2BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 0.05 degrees C 0.14 0.51 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20336 381
SS-Chr 9BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 19 -0.54 degrees C 0.13 0.57 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20347 381
FHH-Chr 16BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 14 0.14 degrees C 0.16 0.61 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20353 381
SS-Chr 17BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 -0.59 degrees C 0.5 1.58 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20357 381
SS-Chr 3BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 0.11 degrees C 0.25 0.86 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20366 381
SS-Chr 1BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.59 degrees C 0.29 0.93 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20380 381
SS-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 154.1 g 4.4 14.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49585 461
Crl:CD(SD) heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 49.4 mmHg 4.69 14.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49589 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 3 0.33 IU/g 0.14 0.24 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49620 461
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 86.7 mmHg 7.37 23.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49624 461
Hsd:SD percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 81.12 % 6.24 19.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49626 461
SS/JrHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 24.0 % 2.52 7.98 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 49627 461
SS/JrHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 8 17.04 % 3.19 9.01 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 49633 461
LE/BluGill percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 87.82 % 3.02 7.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49657 461
GH/OmrMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 0.27 IU/g 0.04 0.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 49678 461
FHH-Chr 6BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 11 6.97 % 1.1 3.64 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49686 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 14 7.8 % 2.44 9.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49688 461
FHH-Chr 10BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 9 4.73 % 0.92 2.76 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49697 461
FHH-Chr 20BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 8 6.05 % 0.89 2.53 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49707 461
SS-Chr 20BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 23 30.02 % 4.06 19.48 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49709 461
FHH-Chr 5BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 8 11.27 % 1.29 3.65 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49728 461
SS-Chr 17BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 8.41 % 2.27 6.8 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49745 461
FHH-Chr 18BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 1061.11 s 41.12 123.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50235 461
FHH-Chr 20BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 1165.78 s 51.59 154.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50236 461
SS-Chr 20BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 25 951.06 s 43.0 214.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50238 461
SS-Chr 13BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 19 1214.0 s 37.6 163.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50239 461
FHH-Chr 4BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 1214.38 s 45.59 128.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50243 461
SS-Chr 12BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1102.7 s 47.78 151.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50248 461
FHH-Chr 15BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 1302.75 s 39.98 113.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50266 461
FHH-Chr 13BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 1176.11 s 57.19 171.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50285 461
FHH/EurMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 48 1204.79 s 33.56 232.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50289 461
SS/JrHsdMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 17 992.33 s 34.2 141.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50298 461
BN/NHsdMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 24 1126.09 s 23.27 113.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50304 461
SS-Chr XBN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 1157.64 s 41.43 137.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50306 461
FHH-Chr 3BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 5 6.72 % 3.09 6.91 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49751 461
SS-Chr 3BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 8 20.92 % 5.35 15.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49753 461
FHH-Chr 3BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 7 9.16 % 1.79 4.75 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49761 461
SS-Chr YBN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 29 14.73 % 2.34 12.61 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49763 461
FHH-Chr 9BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 9 5.65 % 2.34 7.02 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49773 461
SS/JrHsdMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 44.5 mmHg 4.55 12.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 49798 461
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 73.5 mmHg 2.77 6.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49817 461
FHH-Chr 6BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 91.34 mmHg 5.65 15.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49877 461
SS-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 94.24 mmHg 2.77 8.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49883 461
SS-Chr 15BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 93.92 mmHg 6.52 20.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49891 461
SS-Chr 19BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 91.82 mmHg 6.4 15.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49908 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 105.63 mmHg 4.22 12.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49912 461
FHH-Chr 15BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 69.06 mmHg 6.29 14.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49927 461
SS-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 105.38 mmHg 5.66 17.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49937 461
SS-Chr 16BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 16 88.68 mmHg 4.02 16.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49945 461
FHH-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 102.76 mmHg 5.63 17.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49947 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 44 92.22 mmHg 2.74 18.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49950 461
BN/NHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 23 101.61 mmHg 5.04 24.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49966 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 14 51.29 mmHg 4.18 15.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49983 461
FHH-Chr 6BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 11 29.36 mmHg 3.15 10.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49985 461
SHR/NCrl heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 63.0 mmHg 3.24 10.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49991 461
FHH-Chr XBN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 25.13 mmHg 2.0 5.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49993 461
SS-Chr 15BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 40.5 mmHg 2.9 9.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50000 461
FHH-Chr 8BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 29.67 mmHg 2.98 8.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50002 461
SS-Chr 20BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 25 53.72 mmHg 3.18 15.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50008 461
FHH-Chr YBN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 11 21.91 mmHg 2.06 6.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50010 461
FHH-Chr 4BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 28.6 mmHg 2.6 8.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50015 461
SS-Chr 10BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 47.22 mmHg 4.01 12.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50026 461
SS-Chr 6BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 50.44 mmHg 6.59 19.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50030 461
SS-Chr 9BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 17 50.82 mmHg 3.05 12.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50034 461
FHH-Chr 14BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 6 25.83 mmHg 6.05 14.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50038 461
SS-Chr 17BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 35.2 mmHg 2.49 7.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50039 461
SS-Chr 17BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 28.44 mmHg 2.38 7.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50044 461
F344/DuCrl percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 102.86 % 15.16 47.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49263 461
SS-Chr 5BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 824.78 s 43.86 131.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49294 461
FHH-Chr 18BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 908.33 s 39.95 119.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49309 461
FHH-Chr 15BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 928.88 s 27.06 76.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49327 461
FHH-Chr 14BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 4 917.38 s 158.14 316.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49330 461
SS-Chr 6BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 1010.67 s 29.69 89.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49332 461
FHH-Chr 5BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 921.0 s 29.88 89.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49334 461
SS-Chr 9BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 17 705.27 s 44.32 182.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49336 461
SS-Chr 16BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 21 745.5 s 52.6 241.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49356 461
FHH-Chr 13BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 962.22 s 62.3 186.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49357 461
FHH-Chr 11BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 969.9 s 25.92 81.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49371 461
SS-Chr 14BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 20 139.5 g 4.1 18.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49498 461
SS-Chr 6BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 9 163.5 g 2.3 6.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49500 461
SS-Chr 7BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 11 222.9 g 4.0 13.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49516 461
FHH-Chr 17BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 20 169.7 g 3.6 16.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49518 461
FHH-Chr 8BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 136.1 g 3.0 9.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49529 461
SS-Chr 16BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 22 155.8 g 2.9 13.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49533 461
SS-Chr 11BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 24 140.8 g 2.5 12.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49550 461
SS-Chr 11BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 25 172.4 g 5.6 28.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49556 461
FHH-Chr 1BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 154.6 g 7.1 22.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49561 461
SS-Chr 4BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 20 41.1 mmHg 2.22 9.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50067 461
LEW/Crl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 158.2 g 2.7 8.7 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50080 461
FHH-Chr 6BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 1203.0 s 55.81 185.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50215 461
FHH-Chr 2BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 1161.88 s 40.68 115.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50219 461
SS-Chr 5BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 1056.33 s 32.23 96.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50222 461
FHH-Chr 8BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 1155.22 s 49.56 148.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50232 461
Hsd:SD serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 5 2.2 g/dl 0.18 0.39 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 38974 401
SHR/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 18 60.33 % 0.72 3.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38985 401
SS-Chr 15BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 56.14 % 0.78 2.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38994 401
FHH-Chr 8BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 53.77 % 0.92 2.9 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38996 401
FHH-Chr 20BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 54.07 % 0.71 2.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38997 401
FHH-Chr 4BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 51.78 % 1.32 3.73 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39007 401
SS-Chr 12BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 7 53.79 % 0.98 2.6 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39016 401
FHH-Chr 15BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 54.43 % 0.88 2.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39019 401
FHH-Chr 5BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 51.0 % 1.16 3.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39021 401
SS-Chr 6BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 7 61.0 % 1.05 2.77 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39029 401
SS-Chr 9BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 18 3.86 g/dl 0.09 0.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42270 401
FHH-Chr 14BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 2.98 g/dl 0.1 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42274 401
SS-Chr 17BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.56 g/dl 0.07 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42275 401
GH/OmrMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 16 4.03 g/dl 0.08 0.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42277 401
SS-Chr 7BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 12 4.02 g/dl 0.07 0.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42283 401
FHH-Chr 19BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.82 g/dl 0.09 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42286 401
SS-Chr 16BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 13 3.65 g/dl 0.04 0.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42291 401
SS-Chr XBN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 11 3.82 g/dl 0.11 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42302 401
SS/JrHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.9 g/dl 0.03 0.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42305 401
SS/JrHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 7 7.33 mg/dl 0.42 1.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42321 401
WKY/NCrl serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 361.9 U/l 27.6 87.29 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42346 401
WKY/NCrl blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 0.98 x 1000 cells/ul 0.16 0.46 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42366 401
LE/BluGill blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 9 0.6 x 1000 cells/ul 0.07 0.22 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42371 401
SHR/NCrl mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 15 52.17 fl 0.2 0.78 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38742 401
SS-Chr 13BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 12 62.52 fl 0.39 1.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38752 401
FHH-Chr 20BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 59.55 fl 0.23 0.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38754 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 61.48 fl 0.27 0.76 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38764 401
SS-Chr 9BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 15 61.4 fl 0.41 1.6 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38782 401
SS-Chr 10BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 61.28 fl 0.49 1.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38785 401
FHH-Chr 17BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 6 57.8 fl 0.33 0.81 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38791 401
FHH-Chr 19BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 57.5 fl 0.55 1.75 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38798 401
SS-Chr 16BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 13 62.38 fl 0.45 1.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38803 401
FHH-Chr 13BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 58.79 fl 0.19 0.61 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38805 401
SS-Chr 3BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 7 59.33 fl 0.48 1.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38806 401
FHH/EurMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 49 57.32 fl 0.3 2.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38808 401
FHH-Chr 3BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 55.73 fl 0.65 1.85 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38809 401
SS-Chr XBN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 11 63.28 fl 0.26 0.88 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38814 401
SS/JrHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 4 4.68 mmol/l 0.34 0.69 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 38828 401
SS-Chr 20BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 55.79 % 1.29 3.65 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38849 401
Hsd:SD blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 18.24 g/dl 0.12 0.47 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38874 401
FHH-Chr 6BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 19.7 mmol/l 1.08 3.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42050 401
FHH-Chr 10BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 16.63 mmol/l 0.86 2.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42055 401
SS-Chr 15BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 21.5 mmol/l 0.5 1.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42066 401
FHH-Chr 18BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 21.1 mmol/l 0.95 3.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42070 401
FHH-Chr 20BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 17.5 mmol/l 0.64 2.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42071 401
SS-Chr 20BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 34 19.21 mmol/l 0.48 2.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42073 401
FHH-Chr YBN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 9 17.78 mmol/l 0.68 2.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42075 401
FHH-Chr 4BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 7 20.57 mmol/l 1.46 3.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42080 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 9 15.11 mmol/l 0.39 1.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42081 401
SS-Chr 19BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 22.3 mmol/l 0.63 2.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42084 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 11 15.27 mmol/l 0.47 1.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42086 401
FHH-Chr 5BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 20.25 mmol/l 0.62 1.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42092 401
SS-Chr 17BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 16.75 mmol/l 1.13 3.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42109 401
FHH-Chr 3BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 20.0 mmol/l 1.07 3.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42116 401
SS-Chr 16BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 13 16.31 mmol/l 0.93 3.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42120 401
SS-Chr YBN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 20 16.1 mmol/l 0.46 2.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42128 401
FHH-Chr 11BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 9 22.11 mmol/l 1.14 3.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42135 401
FHH-Chr 11BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 22.0 mmol/l 0.83 2.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42136 401
FHH-Chr 9BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 7 16.57 mmol/l 2.13 5.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42138 401
BN/NHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 17 16.53 mmol/l 0.56 2.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42141 401
Hsd:SD serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 17 117.12 U/l 6.96 28.7 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42173 401
SS-Chr 16BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 6 6.2 g/dl 0.07 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42192 401
FHH-Chr 2BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.36 g/dl 0.09 0.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42220 401
FHH-Chr 10BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.73 g/dl 0.1 0.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42226 401
FHH-Chr 10BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.61 g/dl 0.12 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42232 401
FHH-Chr XBN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 7 3.46 g/dl 0.03 0.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42233 401
FHH-Chr 8BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.89 g/dl 0.06 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42238 401
SS-Chr 20BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 34 3.74 g/dl 0.03 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42244 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 9 4.23 g/dl 0.04 0.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42252 401
GH/OmrMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 16 59.13 % 0.49 1.95 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39040 401
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 16 52.99 % 0.9 3.61 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39043 401
SS-Chr 16BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 15 58.62 % 0.59 2.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39046 401
SS-Chr 16BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 13 59.88 % 0.64 2.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39049 401
SS-Chr 16BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 7 23.29 mmol/l 0.47 1.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39089 401
SS-Chr 5BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 105.13 mmol/l 0.74 2.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39112 401
SS-Chr 20BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 27 104.67 mmol/l 0.53 2.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39119 401
SS-Chr 15BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 107.25 mmol/l 0.45 1.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39121 401
SS-Chr 13BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 12 110.0 mmol/l 1.24 4.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39124 401
SS-Chr 20BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 34 105.85 mmol/l 0.84 4.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39128 401
SS-Chr 18BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 109.7 mmol/l 1.72 5.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39131 401
SS-Chr 19BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 106.8 mmol/l 0.47 1.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39139 401
SS-Chr 2BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 109.5 mmol/l 0.48 1.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39140 401
SS-Chr 12BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.56 g/dl 0.1 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42254 401
SS-Chr 6BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 9 4.16 g/dl 0.07 0.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42266 401
SS-Chr 9BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 17 3.68 g/dl 0.05 0.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42267 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 11 78.36 U/l 5.37 17.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42794 401
SS-Chr 17BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 81.25 U/l 3.59 10.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42817 401
FHH-Chr 16BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 9 77.67 U/l 2.35 7.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42821 401
SS-Chr 16BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 14 82.0 U/l 4.56 17.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42828 401
FHH/EurMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 51 105.61 U/l 4.06 28.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42833 401
FHH-Chr 11BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 9 90.33 U/l 5.65 16.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42843 401
SS-Chr 5BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 7 142.0 mmol/l 1.36 3.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39386 401
SS-Chr 15BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 142.5 mmol/l 0.58 1.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39391 401
FHH-Chr 20BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 142.4 mmol/l 0.87 2.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39394 401
SS-Chr 20BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 34 142.59 mmol/l 0.56 3.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39399 401
SS-Chr 18BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 9 140.33 mmol/l 1.2 3.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39402 401
FHH-Chr 4BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 142.5 mmol/l 0.89 2.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39404 401
SS-Chr 18BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 9 137.44 mmol/l 0.99 2.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39405 401
FHH-Chr 15BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 142.13 mmol/l 1.26 3.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39427 401
FHH-Chr 14BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 145.0 mmol/l 0.68 1.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39429 401
GH/OmrMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 15 142.6 mmol/l 0.88 3.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39432 401
FHH-Chr 3BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 9.2 x 10E6 cells/ul 0.2 0.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39301 401
SS-Chr YBN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 20 10.14 x 10E6 cells/ul 0.12 0.54 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39303 401
SS-Chr 4BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 27 8.95 x 10E6 cells/ul 0.07 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39308 401
FHH-Chr 9BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 6 8.66 x 10E6 cells/ul 0.57 1.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39313 401
FHH-Chr 7BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 9.49 x 10E6 cells/ul 0.15 0.46 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39319 401
F344/DuCrl serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 18 9.41 mg/dl 0.16 0.68 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42523 401
F344/DuCrl serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 17 9.52 mg/dl 0.12 0.49 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42528 401
FHH-Chr 12BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 18.31 pg 0.06 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42530 401
FHH-Chr 12BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 17.95 pg 0.07 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42536 401
SHR/NCrl mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 18 17.36 pg 0.08 0.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42539 401
SS-Chr 5BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 20.24 pg 0.09 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42540 401
SS-Chr 16BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 6 0.5 x 1000 cells/ul 0.07 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 42751 401
SS-Chr 16BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 7 1.16 x 1000 cells/ul 0.11 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 42752 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 64.9 U/l 2.73 8.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42760 401
FHH-Chr XBN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 116.5 U/l 14.81 41.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42766 401
SS-Chr 5BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 7 84.0 U/l 5.39 14.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42768 401
FHH-Chr 10BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 102.63 U/l 5.98 16.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42769 401
FHH-Chr XBN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 7 95.43 U/l 4.02 10.64 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42770 401
SS-Chr 20BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 27 74.96 U/l 3.83 19.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42772 401
SS-Chr 13BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 12 73.08 U/l 2.55 8.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42777 401
SS-Chr 13BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 11 79.27 U/l 8.27 27.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42782 401
SS-Chr 18BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 9 65.22 U/l 4.86 14.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42787 401
FHH-Chr 19BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 142.6 mmol/l 0.5 1.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39441 401
SS-Chr 16BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 15 145.4 mmol/l 1.21 4.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39443 401
SS-Chr 11BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 17 143.12 mmol/l 1.49 6.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39450 401
SS-Chr 1BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 6 144.33 mmol/l 0.56 1.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39458 401
SS-Chr XBN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 143.1 mmol/l 0.64 2.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39468 401
FHH/EurMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 17.99 g/dl 0.28 0.75 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 39474 401
SS/JrHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 3 17.97 g/dl 0.39 0.68 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 39478 401
SS-Chr 20BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 25.13 mmol/l 1.29 3.64 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39483 401
SS/JrHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 9 25.0 mmol/l 0.62 1.87 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39484 401
SS-Chr 20BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 26.0 mmol/l 0.68 1.93 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39486 401
LE/BluGill total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 9 4.13 x 1000 cells/ul 0.48 1.44 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39494 401
LE/BluGill serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 17.2 mg/dl 1.18 3.74 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39520 401
SS/JrHsdMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 9 0.3 mg/dl 0.04 0.11 automated plasma creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39540 401
SS-Chr 17BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 110.13 mmol/l 0.93 2.64 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39159 401
FHH-Chr 3BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 109.63 mmol/l 0.71 2.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39171 401
SS-Chr 1BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 6 106.17 mmol/l 1.49 3.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39185 401
FHH-Chr 11BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 9 108.33 mmol/l 0.69 2.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39190 401
SS-Chr 4BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 29 106.97 mmol/l 0.36 1.92 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39192 401
SHR/NCrl red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 18 11.18 x 10E6 cells/ul 0.15 0.63 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39231 401
SS-Chr 5BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 7 8.95 x 10E6 cells/ul 0.09 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39235 401
FHH-Chr 8BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 9.55 x 10E6 cells/ul 0.18 0.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39242 401
FHH-Chr 4BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 8.98 x 10E6 cells/ul 0.24 0.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39253 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 9.52 x 10E6 cells/ul 0.15 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39256 401
SS-Chr 19BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 9.48 x 10E6 cells/ul 0.1 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39257 401
FHH-Chr 15BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 9.38 x 10E6 cells/ul 0.11 0.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39265 401
SS-Chr 14BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 17 8.83 x 10E6 cells/ul 0.09 0.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39269 401
SS-Chr 6BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 8.98 x 10E6 cells/ul 0.09 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39270 401
FHH-Chr 15BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 9.25 x 10E6 cells/ul 0.22 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39276 401
SS-Chr 17BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 8.47 x 10E6 cells/ul 0.23 0.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39279 401
SS-Chr 7BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 11 9.24 x 10E6 cells/ul 0.14 0.46 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39282 401
FHH-Chr 17BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 6 8.46 x 10E6 cells/ul 0.23 0.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39285 401
FHH-Chr 3BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 8.64 x 10E6 cells/ul 0.28 0.8 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39291 401
SS-Chr 16BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 15 9.47 x 10E6 cells/ul 0.09 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39292 401
SS-Chr 3BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 7 8.94 x 10E6 cells/ul 0.1 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39293 401
FHH-Chr 13BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 9.26 x 10E6 cells/ul 0.1 0.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39297 401
F344/NHsd mean arterial blood pressure controlled air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 arterial blood pressure trait male 105 days 23 median 112.0 mmHg vascular indwelling catheter method left common carotid artery 0 0 66128 102
FHH-Chr 14BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 111.63 mmol/l 0.71 2.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39148 401
SS-Chr 9BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 17 108.76 mmol/l 0.57 2.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39151 401
FHH-Chr 5BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 108.75 mmol/l 0.45 1.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39152 401
SS-Chr 9BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 18 107.67 mmol/l 0.78 3.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39154 401
SS-Chr 15BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 20.29 pg 0.19 0.6 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42548 401
FHH-Chr 18BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 18.78 pg 0.07 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42555 401
FHH-Chr 4BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 19.03 pg 0.09 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42563 401
FHH/EurMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 16 18.3 pg 0.11 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42597 401
SS-Chr 3BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 18.96 pg 0.12 0.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42606 401
FHH-Chr 3BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.16 pg 0.05 0.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42609 401
SS-Chr 1BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 6 21.27 pg 0.19 0.46 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42613 401
SS-Chr 4BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 27 19.96 pg 0.07 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42616 401
SS-Chr 4BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 29 20.34 pg 0.06 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42620 401
BN/NHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 19.07 pg 0.09 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42623 401
GH/OmrMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 117.61 % 4.64 12.28 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 54307 381
FHH-Chr 12BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 19 127.71 % 3.97 17.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54309 381
FHH-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 147.99 % 11.65 36.84 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54310 381
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 20 147.52 % 6.83 30.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54314 381
FHH-Chr 10BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 113.65 % 5.79 18.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54317 381
SS-Chr 5BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 125.58 % 14.01 42.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54322 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 49 123.2 % 3.15 22.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54327 381
SS-Chr 20BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 17 134.25 % 6.56 27.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54329 381
SS-Chr 15BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 15 130.33 % 9.52 36.85 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54330 381
SS-Chr 15BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 133.95 % 8.35 26.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54331 381
SS-Chr 13BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 130.36 % 11.38 35.98 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54334 381
BN/NHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 134.12 % 8.01 33.98 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54338 381
SS-Chr 20BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 14 138.31 % 5.58 20.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54340 381
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 122.03 % 3.76 15.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54343 381
FHH-Chr 4BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 151.44 % 15.52 55.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54345 381
SS-Chr 10BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 142.56 % 6.53 21.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54356 381
SS-Chr 14BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 136.71 % 7.86 27.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54363 381
SS-Chr 9BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 17 122.37 % 6.49 26.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54364 381
FHH-Chr 19BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 134.75 % 4.99 18.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54383 381
SS-Chr 1BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 119.36 % 7.03 22.23 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54396 381
SS-Chr 4BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 135.38 % 7.78 30.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54401 381
SS-Chr XBN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 11 32.91 g/dl 0.19 0.61 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39846 401
FHH-Chr 11BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 31.74 g/dl 0.14 0.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39851 401
FHH-Chr 9BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 32.27 g/dl 0.2 0.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39853 401
BN/NHsdMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 13 32.17 g/dl 0.11 0.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39856 401
SS-Chr 16BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 6 1.98 g/dl 0.05 0.12 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Dyets 39965 401
SS-Chr 16BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 7 2.54 g/dl 0.04 0.11 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Dyets 39966 401
SS-Chr 20BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 33 0.9 x 1000 cells/ul 0.07 0.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43235 401
SS-Chr 13BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 11 0.69 x 1000 cells/ul 0.1 0.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43236 401
SS-Chr 19BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 0.63 x 1000 cells/ul 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43244 401
FHH/EurMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 16 0.38 x 1000 cells/ul 0.08 0.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43276 401
FHH-Chr 13BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 1.04 x 1000 cells/ul 0.12 0.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43284 401
SS-Chr 3BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 7 0.76 x 1000 cells/ul 0.14 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43285 401
LEW/Crl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 20 123.39 % 4.3 19.25 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54521 381
Hsd:SD serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 18 92.39 mg/dl 4.17 17.69 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43106 401
SHR/NCrl blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 18 0.96 x 1000 cells/ul 0.12 0.53 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43218 401
FHH-Chr 2BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.33 mg/dl 0.03 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39568 401
SHR/NCrl mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 15 32.11 g/dl 0.13 0.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39774 401
FHH-Chr 8BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 32.34 g/dl 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39782 401
FHH-Chr 4BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 31.78 g/dl 0.11 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39793 401
SS-Chr 19BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 32.11 g/dl 0.23 0.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39797 401
SS-Chr 2BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 32.0 g/dl 0.16 0.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39800 401
SS-Chr 17BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 33.61 g/dl 0.66 1.87 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39819 401
SS-Chr 7BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 32.91 g/dl 0.12 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39827 401
SS-Chr 3BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 31.96 g/dl 0.21 0.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39838 401
SS-Chr 11BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 17 32.24 g/dl 0.1 0.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39839 401
SS-Chr YBN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 20 32.12 g/dl 0.07 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39843 401
FHH-Chr 10BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.23 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39575 401
SS-Chr 20BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 27 0.31 mg/dl 0.02 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39578 401
SS-Chr 15BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.38 mg/dl 0.03 0.1 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39579 401
FHH-Chr 20BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.26 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39582 401
SS-Chr 18BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.25 mg/dl 0.03 0.1 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39590 401
SS-Chr 12BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.34 mg/dl 0.03 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39597 401
SS-Chr 2BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 14 0.27 mg/dl 0.02 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39603 401
FHH-Chr 3BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.31 mg/dl 0.03 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39630 401
FHH-Chr 19BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.27 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39633 401
SS-Chr 3BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 6 0.43 mg/dl 0.05 0.12 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39637 401
FHH-Chr 3BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.31 mg/dl 0.04 0.11 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39640 401
SS-Chr 11BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 15 0.34 mg/dl 0.03 0.12 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39641 401
SS-Chr 4BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 29 0.35 mg/dl 0.01 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39651 401
FHH-Chr 7BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.33 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39653 401
BN/NHsdMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 20 0.24 mg/dl 0.01 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39654 401
SS-Chr 15BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.28 x 1000 cells/ul 0.1 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39677 401
FHH-Chr 20BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.27 x 1000 cells/ul 0.04 0.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39683 401
SS-Chr 13BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 11 0.31 x 1000 cells/ul 0.08 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39686 401
FHH-Chr 1BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 13 0.28 x 1000 cells/ul 0.05 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39689 401
SS-Chr 18BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.11 x 1000 cells/ul 0.04 0.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39691 401
SS-Chr 19BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.45 x 1000 cells/ul 0.07 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39694 401
Hsd:SD blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 16 0.8 x 1000 cells/ul 0.12 0.49 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43409 401
SS-Chr 16BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 7 1.11 g/kg 0.01 0.02 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 58876 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.15 mg/kg 0.26 0.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58896 526
SS-Chr 15BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 0.86 mg/kg 0.16 0.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58910 526
FHH-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.32 mg/kg 0.19 0.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58914 526
SS-Chr 12BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 1.64 mg/kg 0.29 0.78 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58927 526
SS-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.54 mg/kg 0.23 0.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58929 526
FHH-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 1.02 mg/kg 0.22 0.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58941 526
SS-Chr 14BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 19 0.91 mg/kg 0.09 0.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58942 526
FHH-Chr 17BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.36 mg/kg 0.27 0.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58952 526
FHH-Chr 19BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.84 mg/kg 0.27 0.81 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58959 526
FHH-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.71 mg/kg 0.41 1.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58960 526
FHH-Chr 19BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 1.84 mg/kg 0.44 1.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58963 526
FHH-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 2.54 mg/kg 0.52 1.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58966 526
SS-Chr 16BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 7 0.4 mg/dl 0.04 0.1 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Dyets 40380 401
SS/JrHsdMcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 3 0.25 x 1000 cells/ul 0.07 0.11 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40388 401
FHH-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 1.65 mg/kg 0.45 1.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58983 526
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 130.0 % 8.87 26.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53724 381
SHR/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 159.18 % 10.25 30.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53728 381
Hsd:SD FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 39.48 ml/min/kg 5.03 12.33 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59029 526
FHH/EurMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 0.23 mmHg x min x kg x ml-1 0.02 0.06 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Dyets 59032 526
FHH-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 157.3 g 3.9 12.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59054 526
SS-Chr 15BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 14 149.9 g 6.1 22.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59066 526
FHH-Chr 1BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 16 178.9 g 3.3 13.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59077 526
SS-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 156.2 g 2.9 9.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59087 526
SS-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 16 210.1 g 7.5 30.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59089 526
SS-Chr 6BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 179.6 g 3.4 10.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59095 526
FHH-Chr 14BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 116.3 g 5.3 16.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59103 526
GH/OmrMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 35 159.3 g 2.5 14.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59106 526
FHH-Chr 19BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 186.5 g 13.6 42.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59115 526
SS-Chr 3BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 15 184.0 g 12.4 47.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59118 526
FHH-Chr 3BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 0.58 x 1000 cells/ul 0.09 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43288 401
SS-Chr 11BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 15 0.94 x 1000 cells/ul 0.1 0.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43289 401
SS-Chr 4BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 27 1.07 x 1000 cells/ul 0.05 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43295 401
SS-Chr XBN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 10 1.05 x 1000 cells/ul 0.09 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43304 401
SS-Chr 2BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.36 x 1000 cells/ul 0.06 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39697 401
SS-Chr 14BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 17 0.2 x 1000 cells/ul 0.05 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39706 401
FHH-Chr 3BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.18 x 1000 cells/ul 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39738 401
SS-Chr XBN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.34 x 1000 cells/ul 0.05 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39754 401
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 109.7 % 5.79 15.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54548 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 102.19 % 5.96 16.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54550 381
SS-Chr 16BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 121.48 % 11.35 30.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53545 381
SS-Chr 16BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 6 98.24 % 4.51 11.05 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53572 381
SS-Chr 16BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 6 143.58 % 6.5 15.93 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53588 381
GH/OmrMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 133.84 % 9.94 28.12 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53589 381
SS-Chr 16BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 136.42 % 6.19 13.83 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53592 381
SS-Chr 10BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 8.14 x 1000 cells/ul 0.24 0.75 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40955 401
SS-Chr 6BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 4.05 x 1000 cells/ul 0.52 1.46 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40959 401
FHH-Chr 5BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 6.46 x 1000 cells/ul 0.7 1.97 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40961 401
GH/OmrMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 16 4.98 x 1000 cells/ul 0.6 2.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40975 401
FHH-Chr 16BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 9 5.24 x 1000 cells/ul 0.16 0.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40977 401
FHH-Chr 19BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 7.64 x 1000 cells/ul 0.81 2.55 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40979 401
FHH/EurMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 49 5.31 x 1000 cells/ul 0.32 2.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40989 401
SS-Chr 1BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 6 6.93 x 1000 cells/ul 0.56 1.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40994 401
SS-Chr 20BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 2.29 g/dl 0.1 0.27 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40495 401
SS/JrHsdMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 2.24 g/dl 0.03 0.11 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40500 401
LEW/Crl blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40507 401
LE/BluGill blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.03 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40510 401
Hsd:SD blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 15 6.5 x 1000 cells/ul 0.51 1.96 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40513 401
FHH/EurMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 31.97 g/dl 0.12 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40533 401
FHH-Chr 12BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 12 2.02 g/dl 0.03 0.1 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40535 401
FHH-Chr XBN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.2 g/dl 0.05 0.14 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40546 401
FHH-Chr 10BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.34 g/dl 0.1 0.27 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40549 401
FHH-Chr 8BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.5 g/dl 0.03 0.11 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40555 401
SS-Chr 13BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 12 2.38 g/dl 0.03 0.1 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40557 401
FHH-Chr 1BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 15 1.81 g/dl 0.04 0.15 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40565 401
FHH-Chr 4BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.59 g/dl 0.06 0.18 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40566 401
FHH-Chr 17BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 6 1.32 g/dl 0.02 0.04 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40596 401
FHH-Chr 9BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 6 49.02 % 3.55 8.69 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59333 526
FHH-Chr 9BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 6 53.2 % 1.49 3.65 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59338 526
Hsd:SD serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 16 0.26 mg/dl 0.02 0.07 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37532 401
F344/DuCrl serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 18 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37544 401
WKY/NCrl serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 9 0.29 mg/dl 0.03 0.08 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37548 401
F344/DuCrl plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 17 24.59 mmol/l 0.42 1.73 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37559 401
SS/JrHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 20.48 pg 0.25 0.8 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37566 401
FHH-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 56.6 % 1.01 2.84 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59249 526
SHR/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 14 54.6 % 0.83 3.09 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59254 526
FHH-Chr 20BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 54.07 % 0.71 2.25 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59263 526
FHH-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 52.82 % 0.71 2.24 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59265 526
SS-Chr 13BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 11 57.16 % 1.1 3.64 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59269 526
SS-Chr 19BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 53.48 % 0.49 1.56 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59279 526
SS-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 15 58.69 % 0.92 3.58 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59284 526
FHH-Chr 14BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 51.7 % 1.2 3.4 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59288 526
FHH-Chr 15BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 54.14 % 1.65 4.65 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59296 526
FHH-Chr 14BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 53.45 % 1.15 3.24 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59298 526
SS-Chr 17BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 50.0 % 0.87 2.47 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59304 526
FHH-Chr 16BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 9 56.34 % 0.55 1.66 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59308 526
SS-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 7 48.07 % 1.54 4.06 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59318 526
LEW/Crl blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.36 x 1000 cells/ul 0.07 0.21 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40695 401
F344/DuCrl blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 12 0.18 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40697 401
LE/BluGill blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.27 x 1000 cells/ul 0.03 0.09 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40698 401
FHH-Chr 2BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 36.25 U/l 2.4 6.8 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40701 401
SS-Chr 20BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 27 48.48 U/l 2.04 10.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40716 401
GH/OmrMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 16 84.63 U/l 5.98 23.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40758 401
FHH-Chr 16BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 9 45.78 U/l 1.76 5.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40765 401
SS-Chr 3BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 6 50.67 U/l 7.6 18.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40775 401
SS-Chr 1BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 6 48.33 U/l 2.93 7.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40784 401
FHH-Chr 7BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 35.8 U/l 2.35 7.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40791 401
BN/NHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 20 47.55 U/l 3.11 13.92 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40792 401
BN/NHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 17 47.94 U/l 5.69 23.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40793 401
WKY/NCrl plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 9 0.32 mg/dl 0.03 0.08 automated plasma creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40797 401
LEW/Crl plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.23 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40798 401
SS-Chr 3BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 7 1.7 g/dl 0.03 0.08 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40606 401
SS-Chr 16BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 13 2.48 g/dl 0.06 0.2 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40608 401
FHH-Chr 3BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.71 g/dl 0.03 0.08 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40614 401
SS-Chr 1BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 6 1.68 g/dl 0.05 0.12 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40618 401
FHH-Chr 9BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 7 1.47 g/dl 0.05 0.14 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40626 401
FHH-Chr 7BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.32 g/dl 0.03 0.09 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40627 401
BN/NHsdMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 17 1.75 g/dl 0.07 0.31 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40629 401
Hsd:SD serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 18 105.67 mmol/l 0.87 3.71 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40659 401
WKY/NCrl blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.31 x 1000 cells/ul 0.14 0.4 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40689 401
F344/DuCrl blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 14 0.23 x 1000 cells/ul 0.04 0.16 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40692 401
LE/BluGill blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 9 0.19 x 1000 cells/ul 0.04 0.12 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40694 401
FHH-Chr 2BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 9.45 mg/dl 0.27 0.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37586 401
SS-Chr 5BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 7 10.1 mg/dl 0.33 0.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37592 401
SS-Chr 15BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 10 11.07 mg/dl 0.81 2.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37597 401
SS-Chr 20BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 34 9.18 mg/dl 0.12 0.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37605 401
SS-Chr 13BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 11 9.15 mg/dl 0.18 0.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37606 401
SS-Chr 19BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 10.01 mg/dl 0.3 0.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37616 401
FHH-Chr 14BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 10.54 mg/dl 0.54 1.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37625 401
GH/OmrMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 16 8.03 mg/dl 0.34 1.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37638 401
SS-Chr 17BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 9.01 mg/dl 0.41 1.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37641 401
FHH-Chr 17BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 6 8.5 mg/dl 0.48 1.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37642 401
FHH-Chr 19BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 9.16 mg/dl 0.27 0.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37651 401
SS-Chr 11BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 15 10.06 mg/dl 0.52 2.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37659 401
SS-Chr YBN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 20 8.78 mg/dl 0.26 1.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37660 401
FHH-Chr 7BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 9.74 mg/dl 0.53 1.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37671 401
SS-Chr 20BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 23.88 mg/dl 1.04 2.95 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40810 401
FHH-Chr 2BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 21.0 mg/dl 1.05 2.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40815 401
FHH-Chr 6BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 21.1 mg/dl 0.97 3.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40817 401
SHR/NCrl serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 17 23.29 mg/dl 0.83 3.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40825 401
SS-Chr 18BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 9 22.11 mg/dl 1.05 3.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40845 401
SS-Chr 19BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 21.1 mg/dl 0.53 1.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40848 401
FHH-Chr 15BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 28.88 mg/dl 1.75 4.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40856 401
FHH-Chr 5BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 25.25 mg/dl 1.13 3.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40858 401
SS-Chr 6BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 21.0 mg/dl 1.45 4.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40866 401
SS-Chr 7BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 11 21.55 mg/dl 0.72 2.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40873 401
GH/OmrMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 18 20.78 mg/dl 0.56 2.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40877 401
SS-Chr 7BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 12 20.33 mg/dl 0.84 2.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40878 401
SS-Chr 3BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 6 30.67 mg/dl 2.47 6.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40889 401
SS-Chr 1BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 6 19.67 mg/dl 1.17 2.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40896 401
SS/JrHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 25.9 mg/dl 0.89 2.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40900 401
SS-Chr 5BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 5.89 x 1000 cells/ul 0.32 0.92 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40921 401
SS-Chr 15BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 7.06 x 1000 cells/ul 0.45 1.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40929 401
SS-Chr 20BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 33 8.75 x 1000 cells/ul 0.3 1.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40937 401
SS-Chr 13BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 11 6.53 x 1000 cells/ul 0.41 1.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40938 401
FHH-Chr 1BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 9 4.11 x 1000 cells/ul 0.44 1.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40952 401
SS-Chr 10BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.52 g/kg 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59697 526
SS-Chr 17BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.22 g/kg 0.05 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59699 526
FHH-Chr 16BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 9 1.45 g/kg 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59708 526
FHH-Chr 19BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 8 1.51 g/kg 0.05 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59710 526
SS-Chr XBN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 15 1.4 g/kg 0.04 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59726 526
BN/NHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 32 1.34 g/kg 0.03 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59735 526
SS-Chr 20BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.66 null 0.06 0.14 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59740 526
SS/JrHsdMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 31.97 g/dl 0.22 0.71 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41120 401
LEW/Crl serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 18.9 mmol/l 0.66 2.08 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41127 401
F344/DuCrl serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 17 14.53 mmol/l 0.49 2.0 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41129 401
WKY/NCrl serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 9 3.53 g/dl 0.03 0.09 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41131 401
LEW/Crl serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.83 g/dl 0.19 0.61 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41132 401
LE/BluGill serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 9 4.28 g/dl 0.03 0.08 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41136 401
F344/DuCrl serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 17 3.79 g/dl 0.04 0.17 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41139 401
SS-Chr 16BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 7 8.5 x 1000 cells/ul 0.77 2.04 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41144 401
FHH/EurMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 7 63.0 U/l 16.41 43.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 41158 401
Hsd:SD serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 5 114.4 U/l 38.38 85.82 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41169 401
SS/JrHsdMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 64.07 fl 0.85 2.69 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37802 401
SS-Chr 20BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.03 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37806 401
FHH-Chr XBN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 6 4.37 mmol/l 0.22 0.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38066 401
FHH-Chr 8BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 4.44 mmol/l 0.2 0.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38071 401
FHH-Chr 20BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 4.62 mmol/l 0.08 0.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38072 401
SS-Chr 20BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 25 5.21 mmol/l 0.07 0.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38077 401
SS-Chr 18BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 6 5.88 mmol/l 0.22 0.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38080 401
SS-Chr 2BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 9 5.27 mmol/l 0.22 0.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38093 401
FHH-Chr 15BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 5.16 mmol/l 0.31 0.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38094 401
GH/OmrMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 14 4.79 mmol/l 0.11 0.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38110 401
FHH-Chr 17BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 6 4.8 mmol/l 0.14 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38112 401
FHH-Chr 2BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 16.8 g/dl 0.35 0.99 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37955 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 17.25 g/dl 0.51 1.63 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37958 401
SHR/NCrl blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 15 17.69 g/dl 0.27 1.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37965 401
SS-Chr 20BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 26 17.08 g/dl 0.2 1.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37970 401
SS-Chr 13BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 18.63 g/dl 0.43 1.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37980 401
FHH-Chr 4BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 15.74 g/dl 0.37 0.98 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37986 401
SS-Chr 2BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 18.3 g/dl 0.21 0.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37991 401
FHH-Chr 14BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 16.52 g/dl 0.41 1.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37999 401
SS-Chr 10BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 17.72 g/dl 0.26 0.82 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38008 401
FHH-Chr 14BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 16.99 g/dl 0.39 1.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38009 401
FHH-Chr 17BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 15.87 g/dl 0.38 0.94 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38016 401
FHH-Chr 19BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 16.23 g/dl 0.28 0.9 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38025 401
FHH-Chr 13BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 17.48 g/dl 0.16 0.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38028 401
SS-Chr 1BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 18.27 g/dl 0.2 0.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38038 401
FHH-Chr 7BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 17.8 g/dl 0.21 0.65 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38050 401
FHH-Chr 6BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 5.23 mmol/l 0.24 0.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38054 401
SHR/NCrl calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 19 0.12 mmHg x min x kg x ml-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59544 526
FHH-Chr 10BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.13 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59546 526
FHH-Chr XBN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.14 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59547 526
SS-Chr 20BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 27 0.13 mmHg x min x kg x ml-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59549 526
FHH-Chr 8BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.16 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59552 526
SS-Chr 20BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 41 0.16 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59558 526
FHH-Chr YBN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.14 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59560 526
SS-Chr 2BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 0.18 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59574 526
SS-Chr 17BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.11 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59589 526
SS-Chr 3BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 14 0.13 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59603 526
SS-Chr 3BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 0.12 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59608 526
SS/JrHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.17 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59619 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.18 g/kg 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59643 526
FHH-Chr 6BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.79 g/kg 0.04 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59646 526
SHR/NCrl lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 25 1.19 g/kg 0.02 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59651 526
FHH-Chr XBN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 9 1.76 g/kg 0.05 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59657 526
SS-Chr 18BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 29 1.57 g/kg 0.04 0.19 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59674 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 12 1.28 g/kg 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59681 526
FHH-Chr 15BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.64 g/kg 0.05 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59685 526
SS-Chr 10BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.28 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59686 526
FHH-Chr 5BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.85 g/kg 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59687 526
SS-Chr 11BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 17 18.88 mmol/l 1.0 4.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38323 401
SS-Chr 1BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 6 22.33 mmol/l 1.52 3.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38329 401
SS-Chr 1BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 6 21.17 mmol/l 2.24 5.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38331 401
SS-Chr 4BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 29 18.59 mmol/l 0.4 2.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38336 401
FHH-Chr 9BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 7 20.71 mmol/l 1.58 4.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38337 401
BN/NHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 20 23.8 mmol/l 0.48 2.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38339 401
BN/NHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 17 21.41 mmol/l 0.43 1.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38340 401
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 7 58.54 % 1.94 5.14 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38358 401
Crl:CD(SD) blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 16.86 g/dl 0.43 1.3 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38403 401
LE/BluGill blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 19.17 g/dl 0.28 0.9 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38408 401
SS-Chr 16BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 6 103.17 mmol/l 0.7 1.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 38411 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 14 23.43 mmol/l 0.8 3.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38247 401
FHH-Chr 8BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 19.4 mmol/l 0.58 1.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38266 401
SS-Chr 20BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 34 23.53 mmol/l 1.0 5.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38272 401
SS-Chr 12BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 17.75 mmol/l 0.59 1.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38286 401
FHH-Chr 1BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 9 23.67 mmol/l 0.71 2.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38287 401
FHH-Chr 14BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 18.0 mmol/l 1.27 3.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38292 401
SS-Chr 6BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 9 21.67 mmol/l 0.55 1.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38294 401
SS-Chr 9BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 16 23.38 mmol/l 1.07 4.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38295 401
SS-Chr 14BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 20 19.85 mmol/l 0.9 4.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38297 401
SS-Chr 9BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 17 20.88 mmol/l 0.8 3.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38298 401
SS-Chr 6BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 24.13 mmol/l 0.77 2.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38299 401
FHH-Chr 14BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 17.25 mmol/l 0.53 1.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38302 401
FHH-Chr 16BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 9 18.67 mmol/l 1.05 3.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38304 401
FHH-Chr 17BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 6 17.5 mmol/l 1.69 4.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38307 401
FHH-Chr 19BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 16.2 mmol/l 0.49 1.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38318 401
SS-Chr 16BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 13 24.15 mmol/l 1.01 3.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38319 401
SS/JrHsdMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 3 4.37 x 1000 cells/ul 1.1 1.9 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41487 401
FHH-Chr 12BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 12 4.08 x 1000 cells/ul 0.43 1.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41488 401
SHR/NCrl blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 15 2.97 x 1000 cells/ul 0.39 1.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41500 401
FHH-Chr 20BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 6.05 x 1000 cells/ul 0.33 1.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41512 401
SS-Chr 19BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 6.95 x 1000 cells/ul 0.34 1.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41523 401
FHH-Chr 15BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 7.5 x 1000 cells/ul 0.82 2.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41542 401
SS-Chr 16BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 13 5.23 x 1000 cells/ul 0.56 2.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41561 401
SS-Chr 4BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 27 6.09 x 1000 cells/ul 0.19 1.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41574 401
BN/NHsdMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 13 6.03 x 1000 cells/ul 0.42 1.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41582 401
SS-Chr XBN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 5.7 x 1000 cells/ul 0.22 0.69 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41583 401
FHH-Chr 9BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 6 5.43 x 1000 cells/ul 0.4 0.97 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41584 401
FHH-Chr 7BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 5.27 x 1000 cells/ul 0.28 0.88 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41585 401
LEW/Crl serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 41.5 U/l 1.58 4.99 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41599 401
LE/BluGill serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 9 57.44 U/l 1.84 5.53 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41603 401
FHH-Chr 2BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 7 173.14 mg/dl 7.77 20.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38517 401
FHH-Chr 6BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 142.9 mg/dl 4.04 12.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38518 401
FHH-Chr 2BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.05 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41639 401
SS-Chr 12BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 7 0.01 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41672 401
Hsd:SD blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 4 0.5 x 1000 cells/ul 0.06 0.12 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41831 401
SS-Chr 7BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 12 4.53 mmol/l 0.12 0.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38116 401
FHH-Chr 19BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 4.87 mmol/l 0.16 0.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38119 401
SS-Chr 16BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 4.99 mmol/l 0.14 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38124 401
FHH-Chr 13BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 10 4.68 mmol/l 0.2 0.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38126 401
FHH-Chr 3BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 4.63 mmol/l 0.26 0.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38130 401
SS-Chr 4BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 29 4.66 mmol/l 0.07 0.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38137 401
FHH-Chr 11BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 9 4.76 mmol/l 0.26 0.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38139 401
FHH-Chr 11BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.99 mmol/l 0.26 0.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38140 401
SS-Chr 4BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 29 4.26 mmol/l 0.08 0.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38141 401
FHH-Chr 7BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.78 mmol/l 0.17 0.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38143 401
FHH/EurMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 7 58.81 fl 0.27 0.71 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38165 401
Hsd:SD red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 15 8.92 x 10E6 cells/ul 0.3 1.18 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38192 401
F344/DuCrl blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 12 3.09 x 1000 cells/ul 0.26 0.9 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38222 401
FHH-Chr 14BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.05 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41678 401
SS-Chr 14BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 20 0.0 x 1000 cells/ul 0.0 0.01 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41683 401
SS-Chr 6BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 7 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41685 401
SS-Chr 17BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.01 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41689 401
FHH/EurMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 16 0.04 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41699 401
SS-Chr 1BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 6 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41715 401
FHH-Chr 7BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.06 x 1000 cells/ul 0.02 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41724 401
SS-Chr 5BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 7 152.57 mg/dl 5.16 13.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38528 401
FHH-Chr 8BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 138.5 mg/dl 5.5 17.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38531 401
SS-Chr 20BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 34 149.0 mg/dl 2.44 14.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38541 401
FHH-Chr 1BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 15 144.6 mg/dl 6.97 26.99 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38545 401
SS-Chr 2BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 148.7 mg/dl 5.96 18.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38553 401
SS-Chr 12BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 8 153.63 mg/dl 2.43 6.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38555 401
FHH-Chr 14BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 7 136.14 mg/dl 3.73 9.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38561 401
FHH-Chr XBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 213.58 beats/min 9.22 26.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47582 461
SS-Chr 20BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 25 285.22 beats/min 6.48 32.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47593 461
SS-Chr 10BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 265.46 beats/min 7.33 21.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47611 461
FHH-Chr 14BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 4 212.65 beats/min 17.6 35.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47613 461
SS-Chr 9BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 18 281.08 beats/min 9.58 40.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47616 461
SS-Chr 6BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 233.71 beats/min 10.53 33.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47620 461
FHH-Chr 17BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 19 236.15 beats/min 6.55 28.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47630 461
SS-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 21 258.48 beats/min 6.69 30.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47639 461
FHH-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 221.9 beats/min 10.39 32.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47641 461
SS-Chr 1BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 256.02 beats/min 17.02 51.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47651 461
FHH-Chr 9BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 223.94 beats/min 11.48 34.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47657 461
FHH-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 247.25 beats/min 10.15 32.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47658 461
FHH-Chr 9BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 220.0 beats/min 8.17 25.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47662 461
SS/JrHsdMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 72.41 % 5.6 15.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48505 461
FHH-Chr 2BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 20.8 % 3.0 7.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48514 461
FHH-Chr 8BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 35.71 % 7.62 17.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48528 461
FHH-Chr 8BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 44.39 % 6.66 14.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48532 461
FHH-Chr 20BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 47.32 % 5.61 16.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48533 461
SS-Chr 13BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 13 post-ischemic value/pre-ischemic value x 100% 32.27 % 6.9 24.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48539 461
SS-Chr 19BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 43.56 % 5.71 16.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48549 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 32.78 % 10.01 26.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48551 461
FHH-Chr 1BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 35.97 % 3.49 11.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48553 461
FHH-Chr 15BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 27.96 % 7.47 18.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48555 461
SS-Chr 10BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 44.78 % 4.84 11.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48556 461
FHH-Chr 5BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 17.89 % 2.66 5.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48557 461
SS-Chr 9BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 32.05 % 4.54 19.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48561 461
FHH-Chr 12BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 18 7.35 g/kg 0.2 0.85 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45590 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 15 5.82 g/kg 0.12 0.48 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45592 461
FHH-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 52.3 mmHg 3.71 11.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46427 461
SS-Chr 20BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 21 69.06 mmHg 3.64 16.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46428 461
FHH-Chr 1BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 54.65 mmHg 3.65 10.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46432 461
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 12 57.84 mmHg 5.56 19.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46434 461
FHH-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 59.97 mmHg 5.62 13.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46452 461
SS-Chr 9BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 18 64.48 mmHg 2.97 12.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46454 461
SS-Chr 6BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 65.86 mmHg 4.67 13.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46455 461
FHH-Chr 16BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 20 49.1 mmHg 2.76 12.34 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46467 461
BN/NHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 24 39.16 mmHg 2.2 10.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46494 461
WKY/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 199.17 beats/min 23.44 74.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46507 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 294.78 beats/min 8.27 27.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46511 461
SS-Chr 14BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 30.25 % 5.26 17.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48563 461
SS-Chr 9BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 22.25 % 3.02 12.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48564 461
FHH-Chr 17BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 46.16 % 6.4 20.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48573 461
FHH-Chr 17BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 43.73 % 7.11 23.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48575 461
SS-Chr 3BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 32.48 % 4.75 14.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48587 461
FHH/EurMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 39 post-ischemic value/pre-ischemic value x 100% 33.93 % 2.79 17.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48589 461
FHH-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 131.27 mmHg 9.31 26.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48616 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 115.87 mmHg 7.34 19.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48648 461
FHH-Chr 5BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 128.64 mmHg 9.37 26.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48654 461
SS-Chr 9BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 17 133.02 mmHg 6.03 24.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48658 461
FHH-Chr 13BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 126.87 mmHg 4.66 13.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48683 461
FHH-Chr 11BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 118.82 mmHg 5.22 16.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48696 461
BN/NHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 22 128.16 mmHg 3.9 18.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48702 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 0.13 IU/g 0.04 0.09 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48706 461
FHH/EurMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 25.24 % 8.35 18.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48712 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 93.29 mmHg 8.38 22.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48728 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 108.9 mmHg 4.52 14.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48731 461
SS-Chr 17BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 139.0 mg/dl 6.23 17.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38572 401
GH/OmrMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 15 146.47 mg/dl 5.9 22.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38574 401
SS-Chr 17BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 7 149.0 mg/dl 5.12 13.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38577 401
SS-Chr 4BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 29 152.34 mg/dl 2.5 13.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38601 401
SS/JrHsdMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 10 152.9 mg/dl 4.0 12.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38602 401
SS-Chr 4BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 29 150.69 mg/dl 3.1 16.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38605 401
SS/JrHsdMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 9 137.89 mg/dl 8.16 24.47 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38624 401
FHH-Chr 11BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 9 0.12 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41941 401
BN/NHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 17 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41947 401
FHH-Chr 9BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 7 0.11 mg/dl 0.01 0.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41949 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 15 0.97 g 0.03 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45395 461
FHH-Chr XBN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.58 g 0.04 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45401 461
SS-Chr 15BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 0.98 g 0.04 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45409 461
FHH-Chr 20BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 1.05 g 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45414 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 14 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41854 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41858 401
FHH-Chr XBN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.11 mg/dl 0.01 0.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41864 401
SHR/NCrl serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 17 0.19 mg/dl 0.03 0.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41865 401
SS-Chr 13BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 11 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41880 401
FHH-Chr 4BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 7 0.13 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41886 401
SS-Chr 9BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 17 0.29 mg/dl 0.06 0.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41902 401
SS-Chr 10BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.12 mg/dl 0.01 0.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41908 401
FHH-Chr 19BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41921 401
SS-Chr 16BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 16 0.17 mg/dl 0.02 0.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41923 401
SS-Chr 3BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 7 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41924 401
FHH-Chr 13BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.1 mg/dl 0.01 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41927 401
FHH/EurMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 51 0.13 mg/dl 0.01 0.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41931 401
SS-Chr 11BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 15 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41933 401
SS/JrHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 94 0.15 mg/dl 0.01 0.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41935 401
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 21 0.22 IU/g 0.03 0.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47464 461
FHH-Chr 8BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.52 IU/g 0.07 0.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47466 461
SS-Chr XBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.42 IU/g 0.05 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47485 461
FHH-Chr 4BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 0.15 IU/g 0.03 0.07 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47493 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 45.79 % 11.92 39.53 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47512 461
SS-Chr 16BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 49.29 % 2.8 9.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47514 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 5.86 mmHg 0.7 1.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 47533 461
SS-Chr 16BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 4.25 mmHg 0.29 0.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 47536 461
SS-Chr 17BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.81 g 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45447 461
FHH-Chr 17BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 20 1.15 g 0.07 0.3 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45451 461
SS-Chr YBN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 30 0.97 g 0.03 0.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45470 461
SS-Chr 1BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 11 0.78 g 0.04 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45474 461
SS-Chr 4BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 20 0.8 g 0.03 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45475 461
FHH-Chr 9BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.64 g 0.06 0.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45485 461
SS/JrHsdMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 904.72 s 28.86 95.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48922 461
FHH/EurMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 1096.9 s 77.69 205.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48927 461
FHH-Chr 13BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 14.92 ml/min/kg 0.86 2.72 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57658 526
WKY/NCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 14 350.04 beats/min 18.22 68.19 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16121 381
Hsd:SD heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 2 410.89 beats/min 17.95 25.39 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16122 381
F344/DuCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 12 441.09 beats/min 7.48 25.92 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16125 381
FHH-Chr 12BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 82.98 % 8.82 30.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48741 461
FHH-Chr 8BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 76.33 % 6.74 15.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48761 461
SS-Chr 13BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 83.16 % 3.68 13.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48763 461
SS-Chr 20BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 23 post-ischemic value/pre-ischemic value x 100% 70.34 % 6.12 29.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48767 461
SS-Chr 14BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 15 post-ischemic value/pre-ischemic value x 100% 91.84 % 7.96 30.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48788 461
SS-Chr 9BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 17 post-ischemic value/pre-ischemic value x 100% 72.69 % 2.96 12.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48793 461
FHH-Chr 14BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 92.41 % 7.05 17.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48797 461
FHH-Chr 16BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 98.03 % 5.37 23.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48799 461
SS-Chr 16BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 15 post-ischemic value/pre-ischemic value x 100% 90.29 % 4.34 16.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48813 461
SS-Chr 4BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 97.66 % 4.56 14.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48826 461
Crl:CD(SD) lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 15 1.36 g/kg 0.04 0.17 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57577 526
WKY/NCrl lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.41 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57580 526
FHH-Chr 2BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 13.68 ml/min/kg 0.91 2.74 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57585 526
FHH-Chr 6BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 12.93 ml/min/kg 0.51 1.52 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57586 526
FHH-Chr 12BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 11 13.9 ml/min/kg 0.58 1.91 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57589 526
SS-Chr 5BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 18.26 ml/min/kg 0.72 2.17 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57593 526
SS-Chr 15BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 12.63 ml/min/kg 1.55 4.38 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57602 526
SS-Chr 19BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 19.18 ml/min/kg 0.77 2.43 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57620 526
FHH-Chr 15BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 13.09 ml/min/kg 1.89 5.35 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57626 526
GH/OmrMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 21 10.84 ml/min/kg 0.76 3.49 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57642 526
SS-Chr 16BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 13 8.96 ml/min/kg 0.83 2.99 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57653 526
SS-Chr 3BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 11 13.43 ml/min/kg 0.72 2.38 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57654 526
SS-Chr 1BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 17.14 ml/min/kg 0.41 1.3 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57668 526
FHH-Chr 11BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 17.94 ml/min/kg 0.65 1.83 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57671 526
Crl:CD(SD) calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.15 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57683 526
WKY/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.5 mg/kg 0.36 1.08 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57770 526
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 7 54.11 % 1.48 3.92 microhematocrit tube assay with visual assessment 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57779 526
FHH-Chr 8BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 24.5 ml/min/kg 1.5 4.73 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57805 526
FHH-Chr 20BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 26.25 ml/min/kg 1.45 4.58 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57809 526
SS-Chr 16BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 38.29 degrees C 0.14 0.51 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16631 381
SS-Chr 3BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 37.27 degrees C 0.15 0.48 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16634 381
FHH/EurMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 48 36.9 degrees C 0.13 0.9 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16636 381
FHH-Chr 3BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.11 degrees C 0.1 0.33 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16637 381
FHH-Chr 11BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 5 36.22 degrees C 0.47 1.05 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16646 381
BN/NHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 23 36.11 degrees C 0.21 1.0 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16651 381
SS-Chr XBN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 14 36.75 degrees C 0.17 0.64 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16653 381
Hsd:SD absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 1 0.04 null automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16665 381
F344/DuCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 0.06 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16668 381
F344/DuCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16673 381
LE/BluGill absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16674 381
FHH-Chr XBN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 54.67 ml/min/kg 10.65 30.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57995 526
SHR/NCrl FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 44.72 ml/min/kg 8.86 28.03 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57996 526
SS-Chr 5BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 43.81 ml/min/kg 2.49 7.48 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57997 526
FHH-Chr 10BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 55.46 ml/min/kg 5.43 15.35 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57998 526
SS-Chr 15BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 45.22 ml/min/kg 2.98 8.44 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58002 526
SS-Chr 13BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 11 52.49 ml/min/kg 2.39 7.94 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58006 526
FHH-Chr 18BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 59.72 ml/min/kg 2.38 6.73 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58007 526
FHH-Chr 18BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 62.96 ml/min/kg 3.87 12.23 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58009 526
SS-Chr 18BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 15 42.88 ml/min/kg 2.65 10.27 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58016 526
SS-Chr 19BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 53.22 ml/min/kg 3.96 11.87 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58019 526
FHH-Chr 1BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 50.5 ml/min/kg 3.82 12.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58025 526
SS-Chr 10BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 53.73 ml/min/kg 2.95 9.34 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58028 526
SS-Chr 14BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 19 57.13 ml/min/kg 2.77 12.07 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58031 526
FHH-Chr 5BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 46.96 ml/min/kg 3.74 10.57 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58034 526
SS-Chr 9BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 15 45.14 ml/min/kg 3.66 14.16 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58036 526
FHH-Chr 17BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 61.09 ml/min/kg 4.69 14.84 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58045 526
SS-Chr 3BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 47.56 ml/min/kg 6.07 21.04 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58055 526
SS-Chr 19BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 21.29 ml/min/kg 1.72 5.17 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57820 526
FHH-Chr 15BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 23.68 ml/min/kg 2.79 7.89 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57828 526
SS-Chr 6BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 16.2 ml/min/kg 2.28 7.22 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57833 526
FHH-Chr 5BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 24.07 ml/min/kg 2.17 6.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57835 526
SS-Chr 6BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 11.81 ml/min/kg 1.74 5.23 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57838 526
SS-Chr 10BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 26.95 ml/min/kg 2.23 6.7 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57840 526
SS-Chr 7BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 25.05 ml/min/kg 2.01 6.96 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57845 526
SS/JrHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 12.47 ml/min/kg 0.63 1.78 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57872 526
FHH-Chr 11BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 28.05 ml/min/kg 2.08 5.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57874 526
FHH-Chr 7BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 19.86 ml/min/kg 1.2 2.95 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57877 526
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 1.52 mg/kg 0.29 0.81 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57982 526
FHH-Chr 2BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 56.16 ml/min/kg 4.14 12.42 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57986 526
FHH-Chr 6BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 44.47 ml/min/kg 6.3 18.9 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57987 526
Hsd:SD partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 1 29.5 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16363 381
SS-Chr 18BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 28.71 mmHg 1.16 2.84 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16446 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 9 27.86 mmHg 0.76 2.28 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16448 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 27.08 mmHg 1.33 3.52 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16455 381
FHH-Chr 12BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 19 36.58 degrees C 0.4 1.76 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16557 381
FHH-Chr 20BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 37.04 degrees C 0.21 0.76 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16578 381
SS-Chr 13BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.44 degrees C 0.14 0.43 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16584 381
FHH-Chr 4BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 36.8 degrees C 0.1 0.36 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16588 381
SS-Chr 12BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 37.6 degrees C 0.21 0.69 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16593 381
SS-Chr 10BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 37.53 degrees C 0.14 0.45 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16601 381
SS-Chr 9BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 14 37.39 degrees C 0.12 0.46 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16607 381
SS-Chr 6BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 37.97 degrees C 0.11 0.38 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16611 381
SS-Chr 10BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.3 degrees C 0.21 0.67 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16613 381
FHH-Chr 16BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 14 36.99 degrees C 0.14 0.53 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16616 381
GH/OmrMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 7 37.79 degrees C 0.21 0.55 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16617 381
SS-Chr 7BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.67 degrees C 0.15 0.46 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16618 381
GH/OmrMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 6 37.28 degrees C 0.31 0.75 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16622 381
SS-Chr 7BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.31 degrees C 0.13 0.41 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16623 381
FHH-Chr 19BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 14 36.91 degrees C 0.2 0.73 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16626 381
SS-Chr 20BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 9.76 ml/min/kg 0.85 2.26 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58462 526
SS/JrHsdMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 11 0.44 null 0.03 0.09 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58319 526
FHH-Chr 11BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 62.9 ml/min/kg 9.82 25.97 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58073 526
FHH-Chr 9BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 55.92 ml/min/kg 5.84 14.31 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58080 526
SS-Chr 20BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 7 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58095 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.47 null 0.03 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58099 526
FHH-Chr XBN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 0.46 null 0.05 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58113 526
SS-Chr 20BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 36 0.51 null 0.02 0.12 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58124 526
SS-Chr 13BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.42 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58125 526
SS-Chr 19BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.41 null 0.04 0.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58133 526
SS-Chr 2BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.25 null 0.04 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58136 526
SS-Chr 12BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.46 null 0.03 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58138 526
FHH-Chr 15BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.41 null 0.06 0.17 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58141 526
FHH-Chr 14BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 5 0.49 null 0.03 0.07 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58144 526
SS-Chr 6BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.62 null 0.16 0.47 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58146 526
SS-Chr 14BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 0.54 null 0.03 0.14 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58149 526
FHH-Chr 19BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 0.44 null 0.03 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58170 526
FHH-Chr 13BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.45 null 0.03 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58172 526
FHH-Chr 13BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.39 null 0.02 0.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58173 526
SS-Chr 3BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 11 0.43 null 0.03 0.12 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58174 526
SS-Chr YBN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 18 0.39 null 0.03 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58179 526
FHH-Chr 11BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.42 null 0.04 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58186 526
SS-Chr XBN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.41 null 0.04 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58193 526
FHH/EurMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 7 56.0 % 0.88 2.34 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Dyets 58199 526
SS-Chr 2BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.02 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58512 526
SS-Chr 12BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58514 526
SS-Chr 2BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 16 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58516 526
SS-Chr 6BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58522 526
FHH-Chr 5BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58524 526
SS-Chr 14BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 18 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58525 526
SS-Chr 10BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58529 526
FHH-Chr 16BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 7 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58532 526
GH/OmrMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 30 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58533 526
FHH-Chr 17BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58537 526
FHH-Chr 16BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58540 526
FHH-Chr 3BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58543 526
FHH-Chr 19BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 7 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58546 526
SS-Chr YBN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 20 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58555 526
SS-Chr 1BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.03 mmHg-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58557 526
SS-Chr XBN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 14 0.04 mmHg-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58558 526
SS-Chr 4BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 22 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58560 526
FHH-Chr 11BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 7 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58563 526
FHH-Chr 7BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58566 526
Crl:CD(SD) methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.22 null 0.03 0.1 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58576 526
F344/DuCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 14 59.31 % 0.74 2.77 microhematocrit tube assay with visual assessment 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58585 526
LE/BluGill hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 9 58.07 % 0.79 2.37 microhematocrit tube assay with visual assessment 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58587 526
Hsd:SD body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 6 216.7 g 8.0 19.7 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58598 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 4 1.48 mg/kg 0.21 0.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58599 526
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 3 6.85 mg/kg 0.94 1.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58603 526
FHH-Chr 6BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58478 526
SS-Chr 15BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.03 mmHg-1 0.01 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58492 526
FHH-Chr 20BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58498 526
FHH-Chr 18BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58499 526
SS-Chr 20BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 41 0.04 mmHg-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58500 526
GH/OmrMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 16 3.84 mg/kg 0.47 1.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58950 526
SS-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 13 1.52 mg/kg 0.24 0.85 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58964 526
FHH-Chr 13BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 2.15 mg/kg 0.8 2.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58965 526
SS-Chr 1BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 2.0 mg/kg 0.49 1.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58976 526
SS-Chr 4BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 18 1.1 mg/kg 0.14 0.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58981 526
SS/JrHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.18 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58710 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.4 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58719 526
FHH-Chr XBN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 7 0.49 null 0.04 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58733 526
FHH-Chr 18BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.38 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58743 526
FHH-Chr 4BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.51 null 0.04 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58751 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 9 0.34 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58752 526
SS-Chr 19BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.37 null 0.02 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58755 526
SS-Chr 10BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.41 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58762 526
SS-Chr 14BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 22 0.35 null 0.03 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58765 526
FHH-Chr 16BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.41 null 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58776 526
FHH-Chr 13BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.43 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58792 526
FHH-Chr 13BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.4 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58793 526
SS-Chr 11BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 17 0.34 null 0.02 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58798 526
SS-Chr 1BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 12 0.39 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58803 526
FHH-Chr 9BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.53 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58814 526
FHH-Chr 7BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.43 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58815 526
LE/BluGill methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 13 17.95 ml/min/kg 0.91 3.28 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58839 526
Hsd:SD dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 5 1.01 mg/kg 0.28 0.63 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58883 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 0.6 mg/kg 0.16 0.49 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58884 526
SS-Chr 16BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 6 0.41 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 58887 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 1.38 mg/kg 0.29 0.78 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58892 526
FHH-Chr 10BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 1.7 mg/kg 0.41 1.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58899 526
FHH-Chr 4BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 2.68 mg/kg 0.43 1.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58924 526
Crl:CD(SD) methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 5.48 ml/min/kg 0.35 0.99 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59862 526
LEW/Crl heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.41 null 0.04 0.11 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59967 526
FHH/EurMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.81 null 0.09 0.24 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 60087 526
SS-Chr 16BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 0.91 null 0.11 0.26 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 60089 526
Hsd:SD FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 27.62 ml/min/kg 1.83 4.48 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 60093 526
LEW/Crl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 182.6 g 2.7 8.4 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60097 526
Crl:CD(SD) body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 312.9 g 7.4 23.4 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60098 526
Crl:CD(SD) body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 15 228.3 g 5.5 21.5 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60100 526
WKY/NCrl FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 37.66 ml/min/kg 4.72 14.16 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60135 526
SS-Chr 16BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 6 36.26 ml/min 1.47 3.6 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17469 381
FHH/EurMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 63.83 ml/min 4.33 14.99 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17472 381
LE/BluGill tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 0.33 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16041 381
Hsd:SD percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 25.36 % 4.89 13.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46962 461
FHH-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 4.36 ml/min/g 0.47 1.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44709 461
FHH-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 2.59 ml/min/g 0.2 0.56 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44710 461
FHH-Chr XBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 4.15 ml/min/g 0.36 0.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44714 461
SS-Chr 20BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 19 5.18 ml/min/g 0.28 1.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44720 461
SS-Chr 15BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 5.03 ml/min/g 0.53 1.4 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44722 461
FHH-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 6.91 ml/min/g 0.73 2.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44728 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 5.9 ml/min/g 0.57 1.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44732 461
FHH-Chr 4BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 5.03 ml/min/g 0.48 1.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44736 461
FHH-Chr 14BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 4 8.09 ml/min/g 1.77 3.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44749 461
SS-Chr 9BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 17 6.23 ml/min/g 1.21 4.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44755 461
FHH-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 114.78 mmHg 8.06 25.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45810 461
SS/JrHsdMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 11 1.56 g 0.09 0.29 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 45826 461
GH/OmrMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 7 1.25 g 0.1 0.26 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 45829 461
WKY/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 43.27 mmHg 5.71 16.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45931 461
F344/DuCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 49.94 mmHg 4.72 14.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45934 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 3 49.18 mmHg 6.63 11.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45940 461
SS-Chr 10BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 41.21 IU/g 2.87 8.6 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45951 461
FHH-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 15.63 IU/g 1.38 3.38 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45962 461
FHH-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 27.79 IU/g 2.7 8.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45985 461
SS-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 14 23.08 IU/g 4.09 15.31 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45993 461
SS-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 21.45 IU/g 3.7 10.48 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45995 461
SS-Chr 4BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 17 32.71 IU/g 3.25 13.4 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45999 461
SS-Chr 6BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 7.18 g/kg 0.23 0.7 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45598 461
FHH-Chr 5BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 6.29 g/kg 0.31 0.98 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45602 461
FHH-Chr 12BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 12 7.27 g/kg 0.45 1.57 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45606 461
FHH-Chr 15BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 8.3 g/kg 0.39 1.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45608 461
SS-Chr 15BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 6.24 g/kg 0.18 0.53 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45635 461
FHH-Chr 18BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 7.15 g/kg 0.48 1.43 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45644 461
FHH-Chr YBN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 14 6.68 g/kg 0.22 0.81 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45652 461
SS-Chr 1BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 11 5.18 g/kg 0.15 0.49 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45662 461
SS/JrHsdMcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 6.83 g/kg 0.42 1.34 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45664 461
SS-Chr 19BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 5.95 g/kg 0.24 0.73 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45668 461
SS-Chr 12BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 5.89 g/kg 0.25 0.8 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45677 461
SS-Chr 16BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 38.18 mmHg 7.54 25.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45687 461
SS-Chr 16BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 3 9.49 IU/g 3.99 6.92 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45698 461
SS-Chr 20BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 15 7.93 IU/g 1.03 3.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45708 461
FHH-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 121.86 mmHg 4.68 15.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45714 461
LE/BluGill left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 124.22 mmHg 3.94 9.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47670 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 13 136.71 mmHg 5.52 19.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45715 461
FHH-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 136.34 mmHg 8.96 25.34 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45721 461
SS-Chr 5BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 100.91 mmHg 5.01 14.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45727 461
FHH-Chr XBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 112.2 mmHg 8.09 22.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45729 461
SS-Chr 20BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 22 146.75 mmHg 4.17 19.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45731 461
FHH-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 128.04 mmHg 2.79 7.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45737 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 134.67 mmHg 6.19 20.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45748 461
SS-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 87.24 mmHg 7.84 24.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45750 461
SS-Chr 9BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 17 138.8 mmHg 5.94 24.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45763 461
SS-Chr 6BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 169.02 mmHg 4.34 13.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45767 461
SS-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 140.66 mmHg 8.75 23.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45774 461
FHH-Chr 16BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 123.82 mmHg 6.15 20.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45779 461
FHH-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 137.08 mmHg 8.45 18.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45787 461
SS-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 21 122.5 mmHg 4.58 20.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45793 461
SS-Chr 4BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 107.3 mmHg 4.21 16.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45803 461
SS-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 12.16 ml/min/g 0.6 1.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46651 461
FHH-Chr XBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 9.51 ml/min/g 0.72 2.03 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46653 461
SS-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 10.03 ml/min/g 0.8 2.53 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46678 461
SS-Chr 6BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 11.92 ml/min/g 0.54 1.61 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46686 461
FHH-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 11.64 ml/min/g 0.67 2.02 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46688 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 111.22 mmHg 7.0 20.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 47785 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 5 3.59 ml/min/g 0.36 0.81 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 44902 461
F344/DuCrl time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 746.35 s 33.36 105.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48121 461
Hsd:SD time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 2 90.87 s 18.17 25.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48123 461
WKY/NCrl time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 8 938.39 s 74.29 210.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48126 461
GH/OmrMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 46.9 % 4.98 13.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48133 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 14 3.64 ml/min/g 0.36 1.35 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44769 461
FHH-Chr 19BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 7.07 ml/min/g 1.07 3.37 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44774 461
FHH-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 6.38 ml/min/g 0.72 2.05 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44776 461
FHH-Chr 9BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 6.08 ml/min/g 1.08 3.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44793 461
FHH-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 4.29 ml/min/g 0.35 1.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44799 461
SS-Chr 12BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 42.29 % 3.17 10.03 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47102 461
SS-Chr 2BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 52.88 % 4.88 15.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47104 461
FHH-Chr 15BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 45.08 % 2.81 7.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47105 461
SS-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 55.22 % 6.66 18.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47132 461
FHH/EurMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 47 post-ischemic value/pre-ischemic value x 100% 44.87 % 2.27 15.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47139 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 97 post-ischemic value/pre-ischemic value x 100% 46.49 % 1.74 17.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47143 461
FHH-Chr 7BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 41.32 % 2.69 8.51 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47153 461
FHH-Chr 6BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 5.65 mmHg 0.15 0.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47186 461
FHH-Chr XBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.08 mmHg 0.19 0.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47193 461
SS-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 4.4 mmHg 0.33 0.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47195 461
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.29 mmHg 0.27 0.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47214 461
SS-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 6.39 mmHg 0.15 0.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47220 461
SS-Chr 10BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 5.58 mmHg 0.23 0.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47226 461
SS-Chr 17BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.32 mmHg 0.33 1.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47239 461
FHH-Chr 16BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 20 5.44 mmHg 0.13 0.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47247 461
Crl:CD(SD) arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 9.37 ml/min/g 0.51 1.62 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46176 461
SS-Chr 13BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 54.4 % 2.4 10.47 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47084 461
SS-Chr 19BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 30.25 % 1.7 4.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47097 461
SS-Chr 2BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 52.52 % 3.24 10.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47100 461
SS-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 59.85 mmHg 4.35 13.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46412 461
FHH-Chr 10BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 41.62 mmHg 3.95 11.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46416 461
FHH-Chr 8BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 45.17 mmHg 9.97 28.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46418 461
SS-Chr 15BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 60.9 mmHg 5.27 16.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46420 461
SS-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 20 4.93 mmHg 0.21 0.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47258 461
BN/NHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 23 5.44 mmHg 0.17 0.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47275 461
SS-Chr XBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 4.9 mmHg 0.31 1.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47276 461
FHH-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 4.98 mmHg 0.24 0.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47278 461
FHH-Chr 2BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 77.63 % 6.4 16.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48282 461
F344/DuCrl heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.8 g 0.03 0.11 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45031 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 3 9.99 ml/min/g 1.73 2.99 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45086 461
LEW/Crl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 13.76 ml/min/g 0.66 1.86 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45088 461
F344/DuCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 17.24 ml/min/g 0.66 2.08 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45091 461
WKY/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.47 mmHg 0.12 0.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48014 461
WKY/NCrl time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 1156.24 s 65.58 185.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45101 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 12 267.84 beats/min 40.9 141.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45134 461
FHH-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 191.37 beats/min 9.85 29.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45178 461
SS-Chr 14BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 241.21 beats/min 17.93 67.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45180 461
SS-Chr 16BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 12 10.96 ml/min/g 0.49 1.69 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46286 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 14.87 ml/min/g 2.49 7.05 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46290 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 4 5.5 mmHg 0.65 1.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47375 461
SS-Chr 10BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.39 IU/g 0.09 0.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47423 461
FHH-Chr 6BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 11 0.3 IU/g 0.03 0.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47429 461
SS-Chr 9BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 18 0.42 IU/g 0.15 0.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47431 461
FHH-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 12 0.34 IU/g 0.03 0.1 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47438 461
FHH-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 19 0.27 IU/g 0.02 0.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47450 461
SS-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.3 IU/g 0.07 0.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47451 461
FHH-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.32 IU/g 0.05 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47458 461
SS-Chr 5BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 74.5 % 4.01 12.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48290 461
FHH-Chr 17BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 16 48.52 mmHg 6.4 25.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45318 461
FHH-Chr 13BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 48.17 mmHg 5.56 17.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45329 461
SS-Chr YBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 28 42.56 mmHg 4.23 22.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45335 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 16 41.3 mmHg 5.48 21.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45341 461
FHH-Chr 11BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 31.52 mmHg 6.15 15.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45343 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 127.2 mmHg 2.65 7.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45378 461
FHH/EurMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 5 1.52 g 0.08 0.17 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45382 461
SS-Chr 17BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 222.91 beats/min 9.81 29.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45190 461
FHH-Chr 3BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 150.46 beats/min 36.22 81.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45201 461
SS-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 21 227.83 beats/min 8.01 36.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45202 461
SS-Chr 4BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 17 236.38 beats/min 10.86 44.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45218 461
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 43.71 mmHg 5.28 13.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45245 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 226.32 beats/min 12.63 35.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45247 461
FHH-Chr 6BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 51.81 mmHg 6.63 20.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45258 461
SHR/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 42.24 mmHg 6.2 19.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45264 461
FHH-Chr XBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 42.73 mmHg 4.92 13.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45270 461
FHH-Chr 20BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 56.64 mmHg 4.95 14.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45279 461
FHH-Chr YBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 37.42 mmHg 5.25 16.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45283 461
FHH-Chr 1BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 39.82 mmHg 8.0 23.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45285 461
SS-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 27.17 mmHg 4.91 15.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45291 461
SS-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 74.56 mmHg 9.82 31.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45293 461
FHH-Chr 14BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 24.32 mmHg 2.27 4.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45301 461
SS-Chr 9BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 16 41.85 mmHg 5.15 20.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45304 461
SS-Chr 10BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 47.84 mmHg 8.83 26.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45310 461
SS-Chr 15BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 109.0 % 11.86 31.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48299 461
FHH-Chr 8BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 84.04 % 4.22 12.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48300 461
SS-Chr 20BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 25 post-ischemic value/pre-ischemic value x 100% 82.75 % 11.16 55.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48306 461
SS-Chr 13BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 76.6 % 6.66 29.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48307 461
SS-Chr 19BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 100.39 % 17.82 47.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48315 461
SS-Chr 10BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 79.8 % 4.68 14.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48324 461
FHH-Chr 14BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 102.69 % 11.67 23.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48326 461
SS-Chr 17BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 90.08 % 2.71 8.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48342 461
SS-Chr 16BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 21 post-ischemic value/pre-ischemic value x 100% 86.93 % 2.96 13.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48349 461
SS-Chr 11BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 23 post-ischemic value/pre-ischemic value x 100% 97.61 % 10.18 48.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48359 461
SS-Chr 4BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 17 post-ischemic value/pre-ischemic value x 100% 88.62 % 5.69 23.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48365 461
BN/NHsdMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 24 post-ischemic value/pre-ischemic value x 100% 94.79 % 6.88 33.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48372 461
Crlj:WI body weight controlled air oxygen content (5 %) (for 28 days) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. body mass male 16 days 7 300.0 g 5.0 13.23 body weighing method 0.0 0 103000 2784
GK body weight controlled air oxygen content (21 %) (for 28 days) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. body mass male 16 days 5 379.0 g 2.0 4.47 body weighing method 0.0 0 103001 2784
GK blood glucose level controlled air oxygen content (5 %) (for 28 days) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. blood glucose amount male 16 days 7 201.6 mg/dl 10.8 28.57 blood glucose analysis 0.0 0 103006 2784
Crlj:WI heart left ventricle weight to body weight ratio controlled air oxygen content (21 %) (for 28 days) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart left ventricle mass male 16 days 6 1.75 mg/g 0.04 0.1 post excision weight measurement 0.0 0 103007 2784
GK heart left ventricle weight to body weight ratio controlled air oxygen content (21 %) (for 28 days) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart left ventricle mass male 16 days 5 2.11 mg/g 0.06 0.13 post excision weight measurement 0.0 0 103009 2784
Crlj:WI heart right ventricle weight to body weight ratio controlled air oxygen content (5 %) (for 28 days) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart right ventricle mass male 16 days 7 0.34 mg/g 0.03 0.08 post excision weight measurement 0.0 0 103012 2784
GK mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 5 undefined 108.0 mmHg 8.0 17.89 vascular transducer tipped catheter 0.0 0 103021 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 109.0 mmHg 10.0 26.46 vascular transducer tipped catheter 0.0 0 103024 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) then meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 6 undefined 155.0 mmHg 10.0 24.49 vascular transducer tipped catheter 0.0 0 103027 2784
GK mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 140.0 mmHg 8.0 21.17 vascular transducer tipped catheter 0.0 0 103030 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 102.0 mmHg 11.0 29.1 vascular transducer tipped catheter 0.0 0 103032 2784
Crlj:WI heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 6 90.0 beats/min 15.0 36.74 vascular transducer tipped catheter 0.0 0 103039 2784
Crlj:WI heart rate controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) then meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 6 288.0 beats/min 11.0 26.94 vascular transducer tipped catheter 0.0 0 103047 2784
F344/DuCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 7.51 % 1.5 4.73 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49031 461
LEW/Crl heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 6.93 g/kg 0.15 0.47 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49144 461
F344/DuCrl heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 5.94 g/kg 0.23 0.73 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49146 461
Crl:CD(SD) heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 5.46 g/kg 0.15 0.47 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49147 461
LE/BluGill heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 4.78 g/kg 0.29 0.88 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49152 461
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 102.5 mmHg 7.71 18.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49155 461
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 119.44 % 5.75 23.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53770 381
SS-Chr 10BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 153.01 % 7.34 24.33 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53783 381
FHH-Chr 6BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 108.43 % 6.65 17.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53872 381
SS-Chr 20BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 102.52 % 3.46 14.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53888 381
SS-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 112.37 % 3.7 12.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53908 381
FHH-Chr 5BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 113.37 % 4.95 15.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53916 381
FHH-Chr 5BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 101.84 % 5.83 18.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53921 381
FHH-Chr 14BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 104.43 % 4.94 15.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53927 381
FHH-Chr 16BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 117.64 % 3.17 9.51 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53935 381
FHH-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 119.67 % 8.12 25.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53938 381
SS-Chr 16BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 116.12 % 2.78 10.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53943 381
SS-Chr 11BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 113.8 % 2.7 8.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53947 381
FHH-Chr 13BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 10 52.2 mmHg 1.9 6.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20489 381
FHH-Chr 18BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 51.58 mmHg 1.45 4.11 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20494 381
GH/OmrMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 6 -0.12 degrees C 0.37 0.91 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20359 381
FHH/EurMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 48 0.09 degrees C 0.16 1.11 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20373 381
SS-Chr 4BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 -0.06 degrees C 0.17 0.59 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20381 381
FHH-Chr 9BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.17 degrees C 0.11 0.36 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20386 381
FHH-Chr 4BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 2 0.03 null 0.02 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19816 381
LEW/Crl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 20 125.84 breaths/min 4.01 17.95 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18212 381
SS-Chr 16BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 8 37.44 degrees C 0.18 0.52 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18231 381
BN/NHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 36.54 degrees C 0.15 0.46 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18236 381
FHH-Chr 10BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 26.42 ml/min 1.91 6.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20201 381
SS-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 35.77 ml/min 2.09 6.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20229 381
FHH-Chr 1BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 16 36.64 ml/min 2.19 8.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20234 381
FHH-Chr 16BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 49.75 ml/min 2.91 8.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20260 381
SS-Chr 14BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 56.4 mmHg 1.98 4.85 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20451 381
SS-Chr 14BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 53.97 mmHg 0.86 2.43 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20456 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 152.3 breaths/min 10.08 30.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17689 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 -6.57 mmHg 0.75 1.83 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17711 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 105.23 breaths/min 4.16 11.01 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15586 381
SS-Chr 6BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 98.17 % 4.02 16.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54020 381
FHH-Chr 15BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 101.18 % 5.81 17.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54026 381
FHH-Chr 14BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 97.52 % 4.43 14.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54028 381
FHH-Chr 17BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 93.31 % 2.73 8.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54034 381
SS-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 104.28 % 7.07 23.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54047 381
SS-Chr 1BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 106.82 % 3.13 9.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54053 381
SS-Chr 11BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.37 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15299 381
GH/OmrMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 51.51 ml/min 3.56 10.06 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20124 381
FHH/EurMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 46.04 mmHg 0.7 1.97 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19555 381
SS-Chr 5BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 2 -8.27 mmHg 0.03 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19626 381
FHH-Chr 19BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 -5.12 mmHg 1.05 2.97 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19634 381
FHH-Chr 18BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 -7.44 mmHg 0.71 2.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19651 381
SS-Chr XBN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 3 -6.5 mmHg 2.76 4.78 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19659 381
BN/NHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 34.63 ml/min 3.33 9.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18075 381
SS-Chr 16BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 6 0.26 ml 0.01 0.03 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14620 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.46 ml 0.05 0.18 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14623 381
GH/OmrMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.37 ml 0.02 0.05 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14629 381
SHR/NCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 6 129.72 mmHg 6.02 14.74 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14664 381
SS-Chr 20BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 31 216.39 U/l 8.64 48.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36390 401
SS-Chr 18BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 219.0 U/l 21.48 67.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36393 401
SS-Chr 10BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 8 27.26 mmHg 0.58 1.65 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17215 381
FHH-Chr 12BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 11 30.22 mmHg 0.8 2.67 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17226 381
SS-Chr 17BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 2 30.1 mmHg 1.2 1.7 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17232 381
SS-Chr 2BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 9 27.26 mmHg 1.04 3.12 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17281 381
FHH-Chr 2BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 145.18 % 11.18 35.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13667 381
FHH-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.23 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15220 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 0.37 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15223 381
SS-Chr 13BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.32 ml 0.04 0.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15245 381
FHH-Chr 6BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 1 7.44 null automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17028 381
SHR/NCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 11 7.55 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17045 381
FHH-Chr 13BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 7.49 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17058 381
FHH-Chr 16BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 148.31 breaths/min 8.27 24.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18317 381
SS-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 120.99 breaths/min 8.33 28.84 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18322 381
SS-Chr 1BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 155.85 breaths/min 8.74 27.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18334 381
FHH-Chr 11BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 135.94 breaths/min 13.24 37.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18339 381
FHH-Chr 9BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 121.35 breaths/min 7.36 23.28 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18342 381
FHH-Chr 19BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 40.58 ml/min 3.41 12.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18720 381
GH/OmrMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 416.79 beats/min 8.48 22.45 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18761 381
SS-Chr 16BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 6 %change=VE during 2-3 min hypoxia/control during standard conditions 144.49 % 8.34 20.43 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14142 381
FHH-Chr 13BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 6 132.71 mmHg 5.85 14.32 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14340 381
FHH-Chr 20BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 5 114.28 mmHg 6.39 14.29 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14343 381
FHH/EurMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 18 123.86 mmHg 3.79 16.1 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14351 381
FHH-Chr 4BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 2 135.55 mmHg 26.8 37.9 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14362 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 10 129.34 mmHg 5.74 18.16 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14364 381
FHH-Chr 11BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 126.72 mmHg 7.24 19.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14367 381
SS-Chr 4BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 7 7.49 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17078 381
SS-Chr 2BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 7.5 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17094 381
WKY/NCrl serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 159.2 mg/dl 22.51 71.19 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36319 401
Crl:CD(SD) mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 19.47 pg 0.18 0.55 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36358 401
FHH-Chr 2BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 262.0 U/l 8.87 25.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36366 401
FHH-Chr 6BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 249.4 U/l 4.64 14.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36368 401
FHH-Chr XBN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 7 364.29 U/l 11.86 31.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36379 401
FHH-Chr 20BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 266.9 U/l 5.05 15.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36388 401
SS-Chr 5BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 131.74 % 9.32 27.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13678 381
FHH-Chr 18BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 127.89 % 8.47 28.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13690 381
FHH-Chr YBN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 %change=VE during 2-3 min hypoxia/control during standard conditions 134.97 % 5.66 25.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13693 381
SS-Chr 2BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 6.36 g/dl 0.15 0.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36985 401
FHH-Chr 15BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 4.69 g/dl 0.09 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36990 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 89.7 mg/dl 3.09 9.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37087 401
FHH-Chr XBN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 75.13 mg/dl 3.17 8.97 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37093 401
SS-Chr 5BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 7 73.71 mg/dl 4.38 11.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37095 401
FHH-Chr 18BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 64.4 mg/dl 1.28 4.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37107 401
FHH-Chr 1BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 14 72.64 mg/dl 4.1 15.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37112 401
FHH-Chr 14BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 69.13 mg/dl 2.86 8.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37128 401
SS-Chr 10BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 63.9 mg/dl 3.05 9.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37137 401
SS-Chr 17BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 86.0 mg/dl 2.26 6.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37139 401
SS-Chr 7BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 11 96.82 mg/dl 4.65 15.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37142 401
FHH-Chr 17BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 6 64.33 mg/dl 1.89 4.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37145 401
SS/JrHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 67.1 mg/dl 1.42 4.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37169 401
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 0.38 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14899 381
FHH/EurMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 4 -46.41 mmHg 2.24 4.48 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18640 381
GH/OmrMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 7 -47.66 mmHg 2.4 6.35 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18646 381
FHH-Chr 8BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 45.25 ml/min 4.16 12.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18667 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 39.48 ml/min 2.07 6.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18681 381
SS-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 40.38 ml/min 3.35 11.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18683 381
SS-Chr 10BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 42.72 ml/min 3.99 13.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18691 381
SS-Chr 9BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 48.12 ml/min 3.13 9.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18697 381
SS-Chr 20BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 11 399.15 beats/min 15.47 51.32 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17521 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 61 412.19 beats/min 6.25 48.79 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17529 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 10 452.93 beats/min 8.97 28.36 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17534 381
SS-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 111.3 breaths/min 5.55 18.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14856 381
FHH-Chr 7BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 106.95 breaths/min 8.95 29.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14872 381
FHH-Chr 1BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 9 8.91 mg/dl 0.11 0.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36650 401
FHH-Chr 5BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.43 mg/dl 0.09 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36659 401
FHH-Chr 17BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 6 9.93 mg/dl 0.11 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36670 401
FHH-Chr 3BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 8.95 mg/dl 0.12 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36678 401
SS-Chr 1BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 6 9.05 mg/dl 0.18 0.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36694 401
Crl:CD(SD) serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 9 8.22 mg/dl 0.22 0.66 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36719 401
SS-Chr 20BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.06 mg/dl 0.11 0.32 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36727 401
SS-Chr 16BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 6 131.17 U/l 6.93 16.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36735 401
SS/JrHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 7 142.71 U/l 8.0 21.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36738 401
SS-Chr 13BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 120.57 breaths/min 7.13 21.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14806 381
FHH-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.23 ml 0.01 0.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13933 381
SS-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 0.47 ml 0.04 0.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13950 381
SS-Chr YBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 0.43 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13990 381
SS-Chr 14BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 %change=VE during 2-3 min hypoxia/control during standard conditions 154.5 % 9.92 34.35 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13717 381
SS-Chr 1BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 147.7 % 14.41 45.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13749 381
FHH-Chr 11BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 127.89 % 10.13 30.4 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13755 381
WKY/NCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 %change=VE during 2-3 min hypoxia/control during standard conditions 142.56 % 6.86 27.45 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19299 381
LE/BluGill percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 153.14 % 14.59 46.14 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19305 381
SS-Chr 10BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 0.06 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19758 381
FHH-Chr 17BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 0.04 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19774 381
SS-Chr 15BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 2 0.05 null 0.03 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19791 381
FHH-Chr 10BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 66.0 % 4.33 8.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47070 461
FHH-Chr 10BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 55.33 % 5.02 13.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47076 461
FHH-Chr 8BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 44.01 % 2.51 7.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47078 461
SS-Chr 15BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 49.61 % 2.41 6.38 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47081 461
SS-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 54.01 % 4.26 12.77 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47091 461
FHH-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 49.25 % 8.18 21.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47140 461
SS-Chr YBN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 29 post-ischemic value/pre-ischemic value x 100% 47.98 % 3.14 16.93 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47142 461
SS-Chr XBN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 62.89 % 5.57 18.47 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47156 461
FHH-Chr 7BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 39.21 % 5.97 18.87 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47158 461
SS-Chr 18BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 39.86 % 9.5 26.86 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47169 461
SS-Chr 20BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 25 5.75 mmHg 0.14 0.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47208 461
FHH-Chr YBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 5.89 mmHg 0.11 0.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47210 461
FHH-Chr 15BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 4.97 mmHg 0.33 0.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47225 461
FHH-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.67 mmHg 0.2 0.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47227 461
SS-Chr 12BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 3 -42.7 mmHg 5.64 9.77 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19506 381
SS-Chr XBN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 -45.99 mmHg 3.55 8.69 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19509 381
SS-Chr 16BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 64.45 mmHg 5.15 14.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45058 461
Hsd:SD heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 13 1.56 g 0.05 0.18 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45062 461
GH/OmrMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 5.21 ml/min/g 0.91 2.73 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45100 461
Hsd:SD time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 3 1082.73 s 172.33 298.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45106 461
LEW/Crl time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1054.62 s 36.01 113.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45108 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 1 4.65 IU/g isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45114 461
FHH-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 158.11 beats/min 12.95 34.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45140 461
Hsd:SD left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 5.57 mmHg 0.9 2.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 48168 461
SS-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.93 mmHg 0.24 0.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47242 461
FHH-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 52.44 mmHg 3.49 13.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46402 461
FHH-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 53.91 mmHg 4.94 13.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46404 461
FHH-Chr 6BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 57.3 mmHg 4.89 13.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46406 461
SS-Chr 5BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 64.7 mmHg 2.72 7.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46415 461
SS-Chr 15BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 47.8 mmHg 3.19 8.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46421 461
FHH-Chr 20BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 45.79 mmHg 4.22 12.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46423 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 5.6 mmHg 0.51 1.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47378 461
SS-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 19 0.35 IU/g 0.05 0.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47435 461
SS-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 11 0.32 IU/g 0.04 0.12 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47445 461
FHH-Chr 5BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 80.75 % 4.2 12.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48325 461
FHH-Chr 17BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 17 post-ischemic value/pre-ischemic value x 100% 87.67 % 4.63 19.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48341 461
WKY/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 0.38 IU/g 0.12 0.3 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48377 461
Crl:CD(SD) heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.2 IU/g 0.05 0.15 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48381 461
LE/BluGill heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 11 0.58 IU/g 0.13 0.43 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48383 461
WKY/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.42 IU/g 0.08 0.27 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48385 461
F344/DuCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.56 IU/g 0.05 0.17 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48387 461
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 222.21 beats/min 12.58 30.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45146 461
FHH-Chr 20BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 187.11 beats/min 10.69 32.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45154 461
FHH-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 221.71 beats/min 17.32 51.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45158 461
SS-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 197.99 beats/min 5.97 16.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45173 461
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 198.22 beats/min 8.25 26.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45175 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 10.32 ml/min/g 0.4 1.05 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46289 461
GH/OmrMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 9.69 ml/min/g 0.71 2.12 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 46291 461
SS-Chr 7BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 5.97 g/kg 0.23 0.71 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45620 461
SS-Chr 20BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 15 7.03 g/kg 0.25 0.98 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45628 461
FHH-Chr 20BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 7.09 g/kg 0.19 0.61 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45645 461
FHH-Chr 1BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 6.47 g/kg 0.24 0.76 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45659 461
SS-Chr 4BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 20 4.69 g/kg 0.14 0.61 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45663 461
FHH-Chr 11BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 7.0 g/kg 0.27 0.85 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45670 461
SS-Chr 19BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 5.74 g/kg 0.19 0.59 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45672 461
FHH-Chr 9BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 8.09 g/kg 0.71 2.26 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45674 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 11.43 IU/g 0.72 1.77 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45697 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 10.85 IU/g 1.23 3.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45705 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 5 2.98 IU/g 1.84 4.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45709 461
FHH-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 119.64 mmHg 8.17 24.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45716 461
FHH-Chr 10BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 83.32 mmHg 10.66 21.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45722 461
FHH-Chr 10BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 88.39 mmHg 8.25 24.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45728 461
FHH-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 125.18 mmHg 4.42 11.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45739 461
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 41.42 ml/min 1.75 4.64 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17473 381
SS-Chr 14BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 20 5.5 g/kg 0.27 1.22 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45603 461
SS-Chr 6BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 5.44 g/kg 0.49 1.54 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45605 461
FHH-Chr 17BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 16 216.36 beats/min 35.27 141.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45196 461
FHH-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 182.74 beats/min 21.3 63.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45207 461
SS-Chr YBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 28 203.53 beats/min 7.7 40.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45213 461
SS-Chr 1BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 205.75 beats/min 14.15 37.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45215 461
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 29.89 mmHg 6.0 14.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45284 461
FHH-Chr 4BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 34.45 mmHg 5.96 14.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45286 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 45.05 mmHg 6.67 20.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45294 461
SS-Chr 14BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 45.17 mmHg 6.1 23.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45302 461
SS-Chr 9BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 18 30.51 mmHg 4.3 18.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45307 461
FHH-Chr 15BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 28.17 mmHg 5.21 11.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45309 461
SS-Chr 17BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 43.21 mmHg 3.87 11.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45317 461
SS-Chr 7BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 66.94 mmHg 8.93 28.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45319 461
FHH-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 91.4 mmHg 10.39 29.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45792 461
SS-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 30.01 mmHg 4.66 14.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45330 461
SS-Chr XBN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 54.39 mmHg 4.82 14.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45338 461
FHH-Chr 11BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 26.62 mmHg 4.1 12.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45342 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 143.57 mmHg 7.4 19.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45373 461
GH/OmrMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 232.67 mmHg 6.49 19.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45379 461
SS-Chr 19BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 11.35 ml/min/g 0.31 0.94 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46673 461
FHH-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 11.57 ml/min/g 0.64 2.03 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46683 461
FHH-Chr YBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 5.66 ml/min/g 0.47 1.48 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44731 461
SS-Chr 12BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 5.09 ml/min/g 0.54 1.71 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44739 461
FHH-Chr 1BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 7.43 ml/min/g 0.25 0.79 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44744 461
FHH-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 5.18 ml/min/g 0.87 2.76 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44748 461
SS-Chr 14BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 15 8.0 ml/min/g 1.54 5.98 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44750 461
SS-Chr 14BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 19 6.25 ml/min/g 0.4 1.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44754 461
SS-Chr 6BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 4.75 ml/min/g 0.39 1.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44756 461
WKY/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 143.0 mmHg 8.74 27.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47672 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 15 12.01 ml/min/g 0.67 2.61 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46704 461
BN/NHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 22 135.42 mmHg 3.67 17.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45807 461
FHH-Chr 9BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 111.8 mmHg 9.04 28.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45809 461
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 175.63 mmHg 9.09 25.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45811 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 173.2 mmHg 14.01 31.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45815 461
SS/JrHsdMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 11 509.8 s 68.73 227.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45834 461
LEW/Crl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 45.98 mmHg 7.49 23.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45902 461
SS-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 15 26.61 IU/g 2.95 11.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45955 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 26 26.47 IU/g 2.86 14.59 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45994 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 23.2 IU/g 3.38 10.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46000 461
Hsd:SD percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 3 post-ischemic value/pre-ischemic value x 100% 73.83 % 5.99 10.38 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47891 461
LE/BluGill percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 65.87 % 8.9 25.16 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47893 461
SS-Chr 18BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 7 14.64 % 5.0 13.23 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47997 461
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 4.43 ml/min/g 0.67 1.49 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44771 461
FHH-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 4.62 ml/min/g 0.33 1.04 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44777 461
FHH-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 5.11 ml/min/g 1.21 3.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44781 461
FHH-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 5.42 ml/min/g 0.48 1.53 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44794 461
SS/JrHsdMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 55.12 % 11.26 37.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46031 461
SS-Chr 16BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 56.58 % 10.14 32.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46035 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 30.4 mmHg 6.89 21.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46149 461
SS-Chr 18BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 6 13.93 % 3.29 8.05 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47999 461
FHH/EurMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 56.18 % 5.69 12.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48005 461
LEW/Crl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.83 mmHg 0.24 0.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48007 461
LEW/Crl mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 32.28 g/dl 0.17 0.5 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42730 401
SS-Chr 9BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 17 95.76 U/l 6.83 28.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42804 401
SS-Chr 9BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 18 74.39 U/l 5.44 23.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42807 401
FHH-Chr 17BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 6 100.0 U/l 5.85 14.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42818 401
SS-Chr 3BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 7 88.29 U/l 4.25 11.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42826 401
SS/JrHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 10 85.5 U/l 5.19 16.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42842 401
SS-Chr 4BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 29 68.34 U/l 3.24 17.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42845 401
FHH-Chr XBN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 5.37 x 1000 cells/ul 0.5 1.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41499 401
SS-Chr 4BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 16 63.03 ml/min/kg 5.15 20.61 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58074 526
SS-Chr XBN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 54.42 ml/min/kg 6.94 21.93 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58079 526
Hsd:SD fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 6 0.08 mmHg-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58096 526
FHH-Chr 12BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.5 null 0.04 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58104 526
SHR/NCrl methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 11 0.37 null 0.04 0.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58107 526
FHH-Chr 2BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.36 mg/dl 0.03 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39563 401
FHH-Chr 1BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 15 0.28 mg/dl 0.01 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39591 401
SS-Chr 2BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.28 mg/dl 0.03 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39599 401
SS-Chr 12BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 7 0.23 x 1000 cells/ul 0.04 0.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39699 401
SS-Chr 14BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 20 0.2 x 1000 cells/ul 0.04 0.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39710 401
SS-Chr 16BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 15 0.18 x 1000 cells/ul 0.03 0.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39729 401
SS-Chr 1BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 6 0.25 x 1000 cells/ul 0.06 0.14 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39742 401
FHH-Chr 7BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.29 x 1000 cells/ul 0.07 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39756 401
FHH-Chr 1BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 9 3.22 x 1000 cells/ul 0.38 1.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41529 401
SS-Chr 10BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 7.02 x 1000 cells/ul 0.26 0.84 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41532 401
SS-Chr 9BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 15 5.47 x 1000 cells/ul 0.36 1.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41540 401
FHH-Chr 16BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 9 4.28 x 1000 cells/ul 0.11 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41554 401
SS-Chr 11BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 16 6.42 x 1000 cells/ul 0.52 2.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41565 401
SS-Chr 11BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 15 7.53 x 1000 cells/ul 0.37 1.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41568 401
SS/JrHsdMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 90 5.7 x 1000 cells/ul 0.16 1.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41570 401
SS-Chr 1BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 6 5.21 x 1000 cells/ul 0.33 0.81 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41573 401
FHH-Chr 6BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 7 36.56 degrees C 0.19 0.49 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16561 381
SHR/NCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 18 37.27 degrees C 0.12 0.49 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16569 381
SS-Chr 15BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 15 37.35 degrees C 0.12 0.46 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16575 381
SS-Chr 19BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 8 36.56 degrees C 0.27 0.75 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16592 381
FHH-Chr 15BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.24 degrees C 0.27 0.86 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16600 381
FHH-Chr 5BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 36.78 degrees C 0.18 0.56 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16608 381
WKY/NCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16664 381
FHH-Chr 9BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 5 4.96 mmol/l 0.28 0.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38142 401
SS-Chr 16BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 7 60.99 fl 0.3 0.8 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 38167 401
Crl:CD(SD) blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 9 5.06 x 1000 cells/ul 0.68 2.04 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38216 401
LE/BluGill blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 9 3.33 x 1000 cells/ul 0.43 1.3 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38219 401
WKY/NCrl serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 9 138.0 mmol/l 0.58 1.73 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38243 401
FHH-Chr 10BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 19.63 mmol/l 0.38 1.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38254 401
FHH-Chr XBN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 18.38 mmol/l 0.32 0.92 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38257 401
FHH-Chr 4BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 7 17.43 mmol/l 1.27 3.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38279 401
FHH/EurMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 51 19.69 mmol/l 0.49 3.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38324 401
SS/JrHsdMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 22.5 mmol/l 1.28 4.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38333 401
Hsd:SD left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 3 117.54 mmHg 9.47 16.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49281 461
FHH-Chr 6BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 11 965.27 s 53.98 179.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49287 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 14 778.86 s 50.73 189.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49289 461
SS-Chr 5BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 8 144.38 mg/dl 2.77 7.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38525 401
FHH-Chr 12BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 12 0.04 x 1000 cells/ul 0.01 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41632 401
FHH-Chr 12BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 11 0.05 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41638 401
FHH-Chr 10BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 7 0.01 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41640 401
FHH-Chr YBN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 9 0.07 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41660 401
FHH-Chr 1BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 13 0.03 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41662 401
FHH-Chr 1BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 9 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41673 401
SS-Chr 14BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 17 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41679 401
SS-Chr 9BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 17 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41681 401
FHH-Chr 3BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.1 x 1000 cells/ul 0.03 0.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41701 401
SS-Chr 11BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 17 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41709 401
SS-Chr 16BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 123.06 % 5.77 12.9 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 54306 381
FHH-Chr 16BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 142.79 % 8.73 32.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54370 381
FHH-Chr 13BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 129.64 % 6.46 21.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54386 381
FHH-Chr 11BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 119.65 % 8.99 26.98 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54400 381
FHH-Chr 7BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 136.82 % 15.87 52.62 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54403 381
SS-Chr 12BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 887.3 s 53.31 168.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49320 461
SS-Chr 2BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 846.4 s 64.88 205.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49322 461
SS-Chr 12BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 883.5 s 25.53 80.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49324 461
SS-Chr 2BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 904.2 s 30.66 96.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49326 461
SS-Chr 9BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 16 698.78 s 50.79 203.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49333 461
FHH-Chr 16BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 20 964.6 s 33.62 150.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49349 461
SS-Chr 1BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 758.0 s 53.45 151.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49366 461
SS-Chr 12BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 31.86 g/dl 0.13 0.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39798 401
SS-Chr 12BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 132.38 mg/dl 2.25 6.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38551 401
SS-Chr 2BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 15 158.47 mg/dl 5.61 21.74 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38557 401
SS-Chr 10BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 154.6 mg/dl 5.82 18.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38559 401
SS/JrHsdMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 9 0.46 null 0.06 0.17 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58315 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 15 198.2 g 4.2 16.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49494 461
SS-Chr 20BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 15 142.9 g 2.9 11.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49530 461
FHH/EurMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 60 140.1 g 5.5 42.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49551 461
SS-Chr 18BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 9 147.8 g 13.1 39.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49557 461
SS-Chr 1BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 11 171.5 g 8.7 28.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49559 461
SS-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 154.6 g 9.1 28.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49571 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 12 154.6 g 3.2 11.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49578 461
BN/NHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 24 163.8 g 3.8 18.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49580 461
LEW/Crl heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 47.8 mmHg 2.72 8.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49594 461
Hsd:SD heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 3 61.67 mmHg 7.8 13.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49596 461
LE/BluGill percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 78.17 % 3.71 9.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49662 461
SS/JrHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.19 IU/g 0.05 0.16 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 49675 461
FHH-Chr 12BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 16 9.38 % 3.21 12.83 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49683 461
FHH-Chr 6BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 7 4.27 % 1.49 3.93 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49687 461
FHH-Chr XBN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 8 7.8 % 2.81 7.96 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49698 461
FHH-Chr 4BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 7 11.42 % 2.47 6.54 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49714 461
SS-Chr 12BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 18.75 % 2.96 9.36 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49719 461
FHH-Chr 14BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 4 2.93 % 0.37 0.75 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49729 461
FHH-Chr 5BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 8 23.28 % 7.88 22.3 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49733 461
SS-Chr 16BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 152.87 % 13.11 34.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53726 381
SS-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 134.12 % 11.39 30.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53729 381
SS-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 17 44.55 mmHg 5.3 21.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46429 461
FHH-Chr 1BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 50.14 mmHg 2.18 6.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46443 461
SS-Chr 9BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 16 63.56 mmHg 3.09 12.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46451 461
SS-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 19 52.62 mmHg 2.59 11.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46453 461
FHH-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 46.84 mmHg 6.37 15.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46458 461
SS-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 38.44 mmHg 4.86 15.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46466 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 58.59 mmHg 4.4 16.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46468 461
FHH-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 54.59 mmHg 1.51 4.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46476 461
SHR/NCrl fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 22 0.05 mmHg-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58483 526
FHH-Chr XBN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 7 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58485 526
FHH-Chr 10BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58488 526
SS/JrHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 104 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58556 526
SS-Chr 4BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 18 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58564 526
FHH/EurMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 3 5.76 mg/kg 2.11 3.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58600 526
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 1 93.0 mmHg balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49818 461
FHH-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 77.32 mmHg 3.65 10.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49875 461
FHH-Chr 16BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 20 5.85 % 1.15 5.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49748 461
FHH-Chr 13BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 8 9.82 % 3.38 9.56 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49756 461
SS-Chr 11BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 22 19.43 % 2.56 11.99 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49762 461
SS/JrHsdMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 96 19.81 % 1.68 16.5 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49764 461
FHH-Chr 11BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 8.16 % 1.63 5.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49770 461
SS-Chr 4BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 18 21.57 % 2.84 12.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49772 461
FHH/EurMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 7 42.43 mmHg 3.78 10.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 49797 461
LEW/Crl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 156.78 mmHg 5.67 17.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49801 461
FHH-Chr 18BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.87 x 1000 cells/ul 0.21 0.66 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43234 401
SS-Chr 12BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 1.04 x 1000 cells/ul 0.14 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43245 401
FHH-Chr 16BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 9 0.62 x 1000 cells/ul 0.09 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43267 401
FHH-Chr 3BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.55 x 1000 cells/ul 0.08 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43278 401
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 111.16 % 8.05 25.47 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54563 381
GH/OmrMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 121.04 % 6.71 18.99 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53535 381
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 115.93 % 4.67 17.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53549 381
F344/DuCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 110.44 % 2.87 12.18 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53609 381
FHH-Chr 16BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 9 126.67 mg/dl 4.07 12.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38573 401
SS-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 67.78 mmHg 8.57 27.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49909 461
SS-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 81.85 mmHg 2.26 7.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49913 461
SS-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 117.19 mmHg 14.7 46.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49915 461
FHH-Chr 17BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 16 93.31 mmHg 8.42 33.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49936 461
FHH-Chr 19BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 89.66 mmHg 7.16 22.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49940 461
SS-Chr XBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 82.12 mmHg 6.47 21.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49967 461
FHH-Chr 20BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 31.3 mmHg 3.08 9.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50003 461
SS/JrHsdMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.11 g/kg 0.04 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 58873 526
FHH-Chr 6BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 2.18 mg/kg 0.39 1.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58895 526
FHH-Chr XBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 3.62 mg/kg 0.69 1.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58902 526
SS-Chr 10BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 0.62 mg/kg 0.06 0.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58935 526
FHH-Chr 2BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.18 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41855 401
SS-Chr 15BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.12 mg/dl 0.01 0.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41871 401
FHH-Chr 15BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.13 mg/dl 0.02 0.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41896 401
SS-Chr 14BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 20 0.11 mg/dl 0.01 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41904 401
SS-Chr 20BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 0.63 x 1000 cells/ul 0.13 0.36 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43408 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 15 1.15 g 0.03 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45391 461
FHH-Chr 10BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.57 g 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45404 461
FHH-Chr 4BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.88 g 0.04 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45421 461
SS-Chr 7BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 11 1.22 g 0.05 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45450 461
FHH-Chr 1BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 59.75 U/l 3.9 11.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40740 401
SS-Chr 14BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 17 39.47 U/l 1.58 6.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40746 401
SS-Chr 9BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 17 72.59 U/l 4.23 17.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40748 401
SS-Chr 9BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 18 52.11 U/l 3.76 15.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40751 401
SS-Chr 7BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 11 55.45 U/l 2.41 7.99 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40759 401
SS-Chr 16BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 17 115.09 mmHg 4.51 18.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48678 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 41 117.07 mmHg 3.07 19.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48686 461
BN/NHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 22 140.93 mmHg 3.2 15.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48701 461
SS/JrHsdMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 1.98 % 1.98 3.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 48709 461
GH/OmrMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 144.29 mmHg 12.97 34.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48726 461
FHH-Chr 18BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 83.52 % 1.7 4.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48764 461
FHH-Chr YBN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 84.57 % 7.99 25.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48769 461
SS-Chr 10BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 89.56 % 2.91 7.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48785 461
GH/OmrMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 77.33 % 4.74 14.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48800 461
FHH-Chr 16BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 20 post-ischemic value/pre-ischemic value x 100% 91.47 % 4.07 18.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48806 461
FHH-Chr 19BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 97.37 % 6.4 20.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48812 461
FHH-Chr 18BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 39.33 mmHg 2.23 6.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50007 461
SS-Chr 18BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 44.44 mmHg 7.53 22.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50011 461
FHH-Chr 19BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 30.4 mmHg 2.72 8.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50053 461
SS-Chr 1BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 35.67 mmHg 5.15 15.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50066 461
FHH-Chr 11BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 6 33.83 mmHg 3.44 8.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50070 461
SS-Chr XBN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 11 28.45 mmHg 3.81 12.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50076 461
LEW/Crl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 180.8 g 3.8 12.1 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50085 461
FHH-Chr 15BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.54 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58761 526
SS-Chr 9BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 18 0.42 null 0.02 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58767 526
SS-Chr XBN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 15 0.42 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58802 526
SS-Chr XBN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.4 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58813 526
SS-Chr 13BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 19 0.27 IU/g 0.04 0.16 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47477 461
FHH-Chr YBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 11 0.48 IU/g 0.13 0.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47479 461
FHH/EurMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 5 44.6 mmHg 4.59 10.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47564 461
FHH-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 12 240.81 beats/min 10.48 36.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47573 461
SS-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 253.0 beats/min 10.05 30.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47577 461
FHH-Chr 10BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 228.85 beats/min 11.81 35.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47581 461
FHH-Chr 8BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 251.79 beats/min 5.92 15.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47583 461
FHH-Chr 15BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 223.66 beats/min 14.03 39.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47610 461
SS-Chr 6BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 235.0 beats/min 8.49 25.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47615 461
FHH-Chr 5BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 224.05 beats/min 11.31 33.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47617 461
FHH-Chr 15BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 197.99 beats/min 17.55 49.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47621 461
SS-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 25 262.08 beats/min 5.45 27.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47636 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 50 235.28 beats/min 4.68 33.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47644 461
LEW/Crl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 150.94 mmHg 5.84 18.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47665 461
F344/DuCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 138.4 mmHg 6.21 18.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47667 461
GH/OmrMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 66.02 % 2.67 7.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48502 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 33.9 % 5.61 20.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48517 461
SS-Chr 17BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 37.16 % 5.12 15.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48569 461
FHH-Chr 3BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 37.34 % 4.74 10.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48580 461
SS-Chr 11BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 post-ischemic value/pre-ischemic value x 100% 42.38 % 3.74 13.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48588 461
SS-Chr 4BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 12 post-ischemic value/pre-ischemic value x 100% 43.89 % 4.6 15.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48601 461
FHH-Chr 7BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 46.77 % 4.39 13.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48603 461
FHH-Chr 10BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 78.15 mmHg 10.86 21.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48617 461
SS-Chr 5BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 96.51 mmHg 5.2 14.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48622 461
SS-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 155.92 mmHg 10.04 26.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48651 461
SS-Chr 10BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 112.63 mmHg 5.2 12.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48653 461
SS-Chr 20BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.17 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58712 526
FHH-Chr 8BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 9 0.41 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58734 526
SS-Chr 16BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 6 0.48 mg/dl 0.03 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Dyets 40379 401
SS-Chr YBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 17 1.56 mg/kg 0.23 0.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58972 526
FHH-Chr 10BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 141.8 g 6.7 21.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59061 526
SS-Chr 13BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 12 176.6 g 4.5 15.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59069 526
FHH-Chr 4BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 176.2 g 5.7 17.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59078 526
SS-Chr 12BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 167.6 g 10.8 34.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59083 526
FHH-Chr 16BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 9 209.0 g 3.7 11.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59113 526
FHH-Chr 19BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 135.4 g 5.7 17.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59119 526
SS-Chr 11BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 17 234.4 g 6.4 26.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59127 526
FHH-Chr 11BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 9 1.14 g/dl 0.06 0.17 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40623 401
Crl:CD(SD) blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 9 0.4 x 1000 cells/ul 0.1 0.3 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40691 401
FHH-Chr 6BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 53.3 U/l 3.0 9.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40702 401
FHH-Chr 8BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 46.6 U/l 2.92 9.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40715 401
SS/JrHsdMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 9 2.64 g/dl 0.07 0.22 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40496 401
WKY/NCrl blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.02 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40501 401
SS-Chr 16BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 6 33.1 g/dl 0.19 0.46 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40531 401
SS-Chr 15BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.99 g/dl 0.06 0.18 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40553 401
FHH-Chr 20BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.43 g/dl 0.05 0.15 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40559 401
SS-Chr 18BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 9 2.08 g/dl 0.06 0.19 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40567 401
SS-Chr 12BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.5 g/dl 0.03 0.08 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40575 401
FHH-Chr 15BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.36 g/dl 0.05 0.15 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40578 401
SS-Chr 9BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 17 981.28 s 43.11 177.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50261 461
SS-Chr 14BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 19 1071.53 s 28.17 122.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50263 461
SS-Chr 6BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1108.8 s 37.78 119.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50265 461
SS-Chr 17BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 1177.89 s 55.24 165.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50274 461
SS-Chr 1BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 73.56 % 6.86 19.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48823 461
SS-Chr 1BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 93.13 % 9.7 25.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48825 461
SS/JrHsdMcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 13 post-ischemic value/pre-ischemic value x 100% 79.83 % 4.57 16.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48827 461
FHH-Chr 9BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 76.19 % 7.83 23.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48831 461
FHH-Chr 17BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 6 58.58 fl 0.07 0.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38793 401
FHH-Chr 3BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 56.83 fl 0.37 1.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38799 401
F344/DuCrl heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 16 0.32 null 0.02 0.08 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59974 526
FHH-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 49.13 % 1.7 4.8 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39045 401
SS-Chr 1BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 6 55.93 % 0.83 2.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39061 401
SS-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 6 1.51 mg/kg 0.37 0.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58967 526
FHH-Chr 12BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 11 110.64 mmol/l 0.36 1.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39108 401
FHH-Chr 10BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 108.25 mmol/l 0.75 2.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39110 401
FHH-Chr 19BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.87 g/dl 0.06 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42290 401
SS-Chr 11BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 17 3.96 g/dl 0.07 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42295 401
FHH-Chr 9BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 7 3.0 g/dl 0.12 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42309 401
FHH/EurMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 7 9.74 mg/dl 0.32 0.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42320 401
Hsd:SD serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 5 3.96 g/dl 0.07 0.15 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 42336 401
F344/DuCrl blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 14 0.76 x 1000 cells/ul 0.07 0.28 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42369 401
FHH-Chr 8BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.16 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59548 526
FHH-Chr 20BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.15 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59556 526
SS-Chr 1BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 6 62.77 fl 0.98 2.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38815 401
FHH-Chr 11BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 9 58.24 fl 0.31 0.94 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38818 401
SS-Chr 4BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 29 62.84 fl 0.3 1.61 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38820 401
BN/NHsdMcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 15 59.07 fl 0.23 0.88 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38823 401
SS-Chr 16BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 4.56 mmol/l 0.11 0.28 flame atomic emission spectrometry 0 Moms and pups used in studies were fed Dyets 38831 401
SS-Chr 7BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 11 15.82 mmol/l 1.1 3.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42107 401
SS-Chr 1BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 6 18.5 mmol/l 1.65 4.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42132 401
SS/JrHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 10 17.8 mmol/l 1.0 3.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42134 401
FHH-Chr 6BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 57.24 % 0.65 2.05 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59245 526
SS-Chr 13BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 12 55.92 % 0.58 2.03 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59264 526
FHH-Chr 6BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 57.24 % 0.65 2.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38979 401
FHH-Chr 1BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 9 55.3 % 0.61 1.84 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39017 401
FHH-Chr XBN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 31.25 mg/dl 2.47 6.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40824 401
FHH-Chr 10BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 24.0 mg/dl 1.68 4.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40827 401
FHH-Chr 4BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 7 21.43 mg/dl 2.03 5.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40846 401
SS-Chr 12BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 31.88 mg/dl 2.85 8.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40849 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 20.6 mg/dl 0.87 2.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40852 401
SS-Chr 9BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 17 22.29 mg/dl 0.95 3.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40862 401
FHH-Chr 16BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 9 19.0 mg/dl 1.35 4.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40871 401
FHH-Chr 17BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 6 24.5 mg/dl 0.72 1.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40876 401
FHH-Chr 3BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 22.88 mg/dl 1.61 4.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40882 401
SS-Chr 1BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 6 18.67 mg/dl 0.61 1.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40898 401
BN/NHsdMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 20 19.6 mg/dl 0.44 1.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40906 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 14 6.01 x 1000 cells/ul 0.56 2.11 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40912 401
FHH-Chr XBN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 7.0 x 1000 cells/ul 0.53 1.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40922 401
SS-Chr 20BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 26 7.42 x 1000 cells/ul 0.27 1.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40928 401
SS-Chr 3BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 7 5.56 x 1000 cells/ul 0.69 1.82 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40987 401
SS/JrHsdMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 7.11 x 1000 cells/ul 0.97 3.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40998 401
SS-Chr XBN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 7.09 x 1000 cells/ul 0.25 0.78 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41006 401
FHH-Chr 16BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 9 52.58 % 0.59 1.77 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59300 526
SS-Chr 20BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.45 mg/dl 0.08 0.22 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37530 401
SS/JrHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 10 0.28 mg/dl 0.03 0.09 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37535 401
F344/DuCrl serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 17 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37549 401
LEW/Crl plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 20.8 mmol/l 0.88 2.78 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37552 401
SS-Chr 20BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 11.29 mg/dl 0.58 1.63 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37574 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 8.65 mg/dl 0.39 1.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37584 401
FHH-Chr 4BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 7 9.39 mg/dl 0.39 1.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37612 401
Hsd:SD serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 18 21.56 mg/dl 1.12 4.74 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40811 401
FHH/EurMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 3 11.08 ml/min/kg 2.42 4.18 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 57571 526
F344/DuCrl lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 18 1.23 g/kg 0.04 0.16 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57576 526
FHH-Chr 6BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 14.06 ml/min/kg 1.03 2.92 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57587 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 17.08 ml/min/kg 1.13 3.38 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57617 526
SS-Chr 2BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 11.32 ml/min/kg 0.47 1.9 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57625 526
SS/JrHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.06 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Dyets 57760 526
Hsd:SD fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 6 0.07 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57782 526
FHH-Chr 12BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 24.86 ml/min/kg 1.05 3.64 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57785 526
WKY/NCrl calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.19 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57681 526
F344/DuCrl calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 0.15 mmHg x min x kg x ml-1 0.01 0.05 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57684 526
SS-Chr 13BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 19.75 pg 0.25 0.82 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42557 401
FHH-Chr 1BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 13 18.86 pg 0.32 1.14 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42560 401
SS-Chr 15BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 17.92 g/dl 0.25 0.78 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37971 401
FHH-Chr 20BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 16.25 g/dl 0.16 0.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37977 401
SS-Chr 18BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 17.9 g/dl 0.21 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37982 401
SS-Chr 6BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 18.35 g/dl 0.28 0.79 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38001 401
WKY/NCrl FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 37.84 ml/min/kg 4.55 13.66 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60128 526
LE/BluGill FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 13 40.53 ml/min/kg 2.35 8.47 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60133 526
LEW/Crl serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 9 9.08 mg/dl 0.17 0.5 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42521 401
Crl:CD(SD) serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 9 9.7 mg/dl 0.09 0.26 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42524 401
FHH-Chr XBN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.38 pg 0.08 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42541 401
SS-Chr 5BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 19.86 pg 0.15 0.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42543 401
SS-Chr 16BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 6 37.33 U/l 1.71 4.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 41156 401
Hsd:SD serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 3 46.67 U/l 6.67 11.55 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41170 401
FHH-Chr 1BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.15 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59573 526
SS-Chr 10BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.14 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59587 526
FHH-Chr 16BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.14 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59598 526
FHH-Chr 3BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.16 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59601 526
SS-Chr 1BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.14 mmHg x min x kg x ml-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59615 526
FHH-Chr 17BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.61 g/kg 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59703 526
GH/OmrMcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 34 1.15 g/kg 0.02 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59706 526
SS-Chr 6BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 9 109.89 mmol/l 0.99 2.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39150 401
FHH-Chr 14BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 112.38 mmol/l 0.38 1.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39158 401
SS-Chr 16BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 14 107.86 mmol/l 0.78 2.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39175 401
SS-Chr 3BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 6 109.5 mmol/l 0.92 2.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39178 401
FHH-Chr 11BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 107.5 mmol/l 0.58 1.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39191 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 8.91 x 10E6 cells/ul 0.21 0.66 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39227 401
FHH-Chr 18BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 8.34 x 10E6 cells/ul 0.17 0.53 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39247 401
SS-Chr 20BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.38 mmol/l 0.28 0.79 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39331 401
FHH-Chr 15BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 17.35 g/dl 0.51 1.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38007 401
SS-Chr 17BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 17.35 g/dl 0.3 0.85 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38010 401
SS-Chr 16BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 15 19.01 g/dl 0.25 0.99 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38023 401
SS-Chr YBN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 20 19.79 g/dl 0.26 1.14 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38034 401
SS-Chr XBN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 18.34 g/dl 0.13 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38048 401
FHH-Chr 2BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.71 mmol/l 0.17 0.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38053 401
FHH-Chr 10BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.61 mmol/l 0.29 0.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38059 401
FHH-Chr 10BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 4.36 mmol/l 0.1 0.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38065 401
FHH-Chr 4BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 7 4.43 mmol/l 0.14 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38084 401
WKY/NCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 11 27.25 mmHg 0.42 1.4 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16370 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 10 29.04 mmHg 0.88 2.77 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16447 381
FHH-Chr 14BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 53.12 ml/min/kg 3.89 11.67 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58040 526
FHH/EurMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 11 34.35 ml/min/kg 3.54 11.73 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58051 526
FHH-Chr 3BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 23.72 ml/min/kg 1.41 4.22 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57854 526
FHH-Chr 19BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 30.27 ml/min/kg 1.44 3.81 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57857 526
SS-Chr 11BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 22.66 ml/min/kg 0.7 2.9 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57865 526
FHH-Chr 9BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 33.61 ml/min/kg 2.7 6.61 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57876 526
FHH-Chr 12BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 12 143.58 mmol/l 0.26 0.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39373 401
FHH-Chr 1BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 15 146.2 mmol/l 0.69 2.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39403 401
SS-Chr 9BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 18 142.0 mmol/l 1.03 4.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39425 401
FHH-Chr 17BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 6 145.0 mmol/l 0.52 1.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39434 401
F344/DuCrl serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 17 18.82 mg/dl 0.67 2.77 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39519 401
SS-Chr 20BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.23 x 1000 cells/ul 0.06 0.18 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39533 401
Hsd:SD plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 16 0.41 mg/dl 0.02 0.1 automated plasma creatinine analysis 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39541 401
SS/JrHsdMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 9 6.3 x 1000 cells/ul 0.72 2.17 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39546 401
GK heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 390.0 beats/min 10.0 26.46 vascular transducer tipped catheter 0.0 0 103046 2784
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 149.95 breaths/min 6.09 19.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15381 381
FHH-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.25 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15224 381
FHH-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.24 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15243 381
SS-Chr 20BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 0.38 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15244 381
SS-Chr 19BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 0.38 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15253 381
SS-Chr 19BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.3 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15255 381
SS-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 0.32 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15256 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 0.37 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15257 381
FHH-Chr 14BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.22 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15264 381
SS-Chr 14BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.3 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15265 381
SS-Chr 6BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 0.36 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15267 381
GH/OmrMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 0.35 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15278 381
FHH-Chr 16BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.36 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15285 381
FHH-Chr 19BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 0.29 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15287 381
FHH-Chr 19BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 0.32 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15291 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 49 0.29 ml 0.01 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15297 381
SS-Chr XBN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 0.22 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15303 381
GH/OmrMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 0.4 ml 0.03 0.07 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14633 381
BN/NHsdMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 4 99.09 mmHg 1.82 3.63 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14668 381
SHR/NCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 4 150.49 mmHg 9.72 19.45 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 14671 381
Hsd:SD heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 16 425.19 beats/min 13.38 53.54 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 15756 381
SS-Chr 16BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 126.28 breaths/min 8.55 19.12 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 15584 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 0.37 ml 0.02 0.06 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14624 381
FHH-Chr 6BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 125.54 breaths/min 11.72 31.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14783 381
FHH-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 156.24 breaths/min 8.84 27.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14786 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 144.07 breaths/min 4.5 19.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14791 381
SS-Chr 6BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 13 112.2 mmHg 2.36 8.52 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14307 381
SS-Chr 9BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 8 121.69 mmHg 3.54 10.0 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14308 381
FHH-Chr 17BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 128.35 mmHg 6.12 17.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14324 381
GH/OmrMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 4 163.6 mmHg 6.47 12.95 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14325 381
SS-Chr 5BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 2 103.61 mmHg 24.88 35.19 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14328 381
FHH/EurMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 11 109.41 mmHg 4.87 16.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14333 381
FHH-Chr 19BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 110.41 mmHg 8.6 22.75 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14338 381
FHH-Chr 8BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 6 115.43 mmHg 1.82 4.45 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14341 381
SS-Chr 13BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 10 108.1 mmHg 6.38 20.19 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14345 381
SS-Chr XBN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 6 119.05 mmHg 10.26 25.13 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14357 381
FHH-Chr 11BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 6 61.26 mmHg 34.35 84.15 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14363 381
SS-Chr 19BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 4 124.2 mmHg 7.39 14.79 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14365 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.39 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13643 381
SS-Chr 16BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 0.4 ml 0.03 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13646 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 0.34 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13648 381
SS-Chr 16BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 0.48 ml 0.04 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13649 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.44 ml 0.04 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13650 381
BN/NHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.3 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13652 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.42 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 13653 381
Hsd:SD mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 10 113.27 mmHg 6.46 20.44 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13663 381
FHH-Chr 1BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 116.98 mmHg 6.2 16.39 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14379 381
GH/OmrMcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 161.85 mmHg 3.08 8.15 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14417 381
SS-Chr 20BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 17 124.41 breaths/min 4.31 17.78 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14796 381
FHH-Chr 20BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 133.84 breaths/min 4.86 14.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14800 381
FHH-Chr YBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 21 132.74 breaths/min 6.57 30.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14807 381
SS-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 126.23 breaths/min 8.11 26.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14815 381
SS-Chr 14BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 114.65 breaths/min 6.47 20.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14826 381
FHH-Chr 5BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 146.09 breaths/min 15.57 49.23 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14830 381
FHH-Chr 13BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 127.33 breaths/min 3.37 11.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14855 381
BN/NHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 103.25 breaths/min 4.73 20.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14874 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.36 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14898 381
SS-Chr 18BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 0.33 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14903 381
FHH/EurMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.43 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14905 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.31 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14909 381
SS-Chr 14BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 115.4 % 6.42 20.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54019 381
SS-Chr 9BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 115.74 % 3.86 12.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54021 381
FHH-Chr 16BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 102.2 % 8.19 30.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54030 381
FHH-Chr 17BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 109.07 % 5.02 16.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54032 381
FHH-Chr 13BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 103.66 % 5.36 17.78 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54046 381
SS-Chr 11BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 98.76 % 3.0 9.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54048 381
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 110.31 % 5.41 18.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54052 381
FHH-Chr 11BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 104.6 % 7.54 22.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54060 381
LEW/Crl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 20 100.71 % 3.23 14.46 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54193 381
SS/JrHsdMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 166.29 % 19.96 63.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14040 381
SHR/NCrl percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 158.25 % 7.19 22.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14041 381
SS-Chr 2BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 11 27.69 mmHg 1.06 3.5 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17288 381
Hsd:SD percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 %change=VE during7-9 min hypoxia/control during standard conditions 145.08 % 6.1 13.63 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17333 381
F344/DuCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 %change=VE during7-9 min hypoxia/control during standard conditions 133.03 % 8.01 32.04 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17336 381
FHH-Chr 6BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 %change=VE during 2-3 min hypoxia/control during standard conditions 138.83 % 8.05 21.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13669 381
FHH-Chr 12BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 121.4 % 7.59 25.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13671 381
SS-Chr 5BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 162.77 % 10.09 31.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13675 381
SHR/NCrl percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 %change=VE during 2-3 min hypoxia/control during standard conditions 152.81 % 6.34 26.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13677 381
FHH-Chr XBN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 125.99 % 8.34 26.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13680 381
SS-Chr 3BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 131.38 % 6.78 22.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13742 381
FHH-Chr 18BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 %change=VE during 2-3 min hypoxia/control during standard conditions 137.99 % 11.08 31.33 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13688 381
FHH-Chr 20BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 %change=VE during 2-3 min hypoxia/control during standard conditions 149.2 % 4.58 12.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13689 381
F344/DuCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 12 112.39 mmHg 3.16 10.96 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13879 381
Hsd:SD percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 %change=VE during 2-3 min hypoxia/control during standard conditions 149.13 % 8.25 31.97 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13899 381
FHH-Chr 12BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 0.24 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13908 381
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 20 0.41 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13917 381
SS-Chr 9BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 12 27.38 mmHg 1.25 4.33 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17224 381
SS-Chr 10BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 4 26.1 mmHg 0.75 1.5 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17227 381
SS-Chr 7BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 7 28.01 mmHg 0.93 2.46 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17236 381
SS-Chr 20BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 10 25.82 mmHg 0.81 2.57 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17241 381
SS-Chr 15BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 6 28.63 mmHg 1.78 4.35 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17245 381
SS-Chr 3BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 2 26.75 mmHg 4.15 5.87 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17252 381
FHH-Chr 20BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 4 31.59 mmHg 2.26 4.52 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17253 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 8 26.17 mmHg 0.87 2.46 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17274 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 8 24.99 mmHg 1.01 2.84 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17282 381
BN/NHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 12 31.45 mmHg 1.19 4.12 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17284 381
SS-Chr 9BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 %change=VE during 2-3 min hypoxia/control during standard conditions 133.63 % 7.03 29.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13718 381
GH/OmrMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 6 %change=VE during 2-3 min hypoxia/control during standard conditions 138.49 % 7.54 18.47 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13730 381
FHH/EurMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 %change=VE during 2-3 min hypoxia/control during standard conditions 159.89 % 9.61 37.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13733 381
SS-Chr XBN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 %change=VE during 2-3 min hypoxia/control during standard conditions 139.85 % 9.17 31.78 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13750 381
FHH-Chr 7BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 163.49 % 20.03 66.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13758 381
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 0.4 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 13835 381
FHH-Chr 20BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.27 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13932 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.37 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13942 381
SS-Chr 19BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.28 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13945 381
SS-Chr 9BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 0.37 ml 0.02 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13961 381
SS-Chr 10BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.26 ml 0.01 0.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13964 381
GH/OmrMcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 6 0.43 ml 0.06 0.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13973 381
SS-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.36 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13980 381
SS-Chr 11BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.39 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13989 381
FHH-Chr 7BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.31 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14001 381
Hsd:SD tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 0.48 ml 0.02 0.04 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14008 381
Crl:CD(SD) tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 0.36 ml 0.03 0.1 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14010 381
FHH/EurMcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 152.9 % 17.25 51.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14037 381
WKY/NCruk heart right ventricle weight to left ventricle plus septum weight ratio controlled air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 heart right ventricle mass male 105 days 28 median 0.52 g/g post excision weight measurement 0 11577 102
FHH-Chr 7BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 3 146.22 mmHg 6.39 11.06 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14377 381
SS-Chr 13BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.54 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17070 381
SS/JrHsdMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 55 7.52 null 0.0 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17074 381
SS-Chr 12BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 7.56 null 0.03 0.06 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17084 381
LEW/Crl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 38.61 ml/min 2.29 9.73 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19717 381
Crl:CD(SD) minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 45.22 ml/min 3.8 12.61 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19720 381
F344/DuCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 32.82 ml/min 1.38 5.86 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19724 381
FHH-Chr 12BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 12 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19757 381
SHR/NCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 0.05 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19776 381
FHH-Chr 17BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19778 381
GH/OmrMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 3 0.04 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19779 381
GH/OmrMcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 7 7.52 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20120 381
SS-Chr 15BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 0.04 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19789 381
SS-Chr 3BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 4 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19790 381
SS-Chr 16BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 9 0.03 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19793 381
FHH/EurMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 16 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19805 381
SS/JrHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 49 0.05 null 0.0 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19810 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 34.92 ml/min 3.87 11.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 20702 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 138.45 % 8.14 31.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53750 381
FHH-Chr 20BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 119.24 % 5.44 17.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53760 381
FHH-Chr YBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 21 124.17 % 8.02 36.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53769 381
FHH-Chr 1BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 18 122.48 % 6.61 28.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53771 381
FHH-Chr 14BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 120.57 % 6.67 21.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53795 381
SS-Chr 17BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 121.8 % 7.92 27.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53796 381
SS-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 107.12 % 5.25 18.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53809 381
FHH-Chr 3BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 104.34 % 3.74 11.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53816 381
SS-Chr 4BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 131.87 % 7.59 29.39 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53828 381
SS-Chr XBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 14 118.14 % 9.13 34.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53832 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 106.96 % 3.84 16.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53871 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 20 106.54 % 3.28 14.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53873 381
FHH-Chr XBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 99.17 % 4.31 13.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53879 381
SS-Chr 13BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 123.97 % 10.12 32.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53893 381
SS-Chr 13BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 120.11 % 6.77 20.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53900 381
FHH-Chr 4BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 109.57 % 5.62 20.28 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53904 381
FHH-Chr 14BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 105.24 % 4.43 14.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53917 381
SS-Chr 17BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 112.47 % 4.53 15.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53928 381
SS-Chr 16BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 106.94 % 4.09 15.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53939 381
FHH-Chr 13BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 104.88 % 5.1 16.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53945 381
SS-Chr XBN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 108.33 % 5.76 21.57 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53964 381
FHH-Chr 12BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 103.43 % 8.23 27.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53975 381
FHH-Chr 10BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 98.9 % 5.05 15.98 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53984 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 49 105.11 % 3.3 23.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53987 381
SS-Chr 20BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 94.83 % 2.86 11.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53989 381
FHH-Chr 8BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 106.84 % 6.27 18.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53992 381
Crl:CD(SD) absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 5 -4.05 mmHg 0.58 1.3 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20982 381
F344/DuCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 -6.93 mmHg 0.87 2.45 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20983 381
LEW/Crl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 10 -5.48 mmHg 0.82 2.58 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20986 381
LE/BluGill absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 -5.93 mmHg 0.61 1.49 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20989 381
SS-Chr 13BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 115.14 % 4.7 14.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54001 381
FHH-Chr 15BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 99.58 % 5.2 16.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54015 381
SS-Chr 10BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 101.32 % 2.97 9.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54016 381
LEW/Crl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 20 36.67 degrees C 0.13 0.6 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19996 381
SS-Chr 20BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 10 -7.14 mmHg 0.34 1.07 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19650 381
FHH-Chr 11BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 5 -6.33 mmHg 0.5 1.12 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19669 381
SS-Chr 4BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 -8.52 mmHg 0.54 1.54 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19670 381
FHH-Chr 7BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 3 -9.83 mmHg 1.39 2.4 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19672 381
SS-Chr 2BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 9 -5.97 mmHg 0.73 2.2 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19673 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 7 -6.27 mmHg 0.9 2.39 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19674 381
BN/NHsdMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 -7.76 mmHg 0.88 2.5 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19677 381
SS-Chr 2BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 11 -4.61 mmHg 0.42 1.39 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19680 381
LE/BluGill absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 -48.53 mmHg 1.05 2.57 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20695 381
SS-Chr 18BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 53.73 mmHg 0.9 2.21 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19548 381
BN/NHsdMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 48.85 mmHg 1.43 2.47 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19556 381
SS-Chr 16BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 8 -0.45 degrees C 0.19 0.55 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19575 381
SS/JrHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 -0.42 degrees C 0.11 0.34 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19582 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 9 -6.14 mmHg 1.06 3.17 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19614 381
SS-Chr 6BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 10 -5.32 mmHg 0.66 2.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19617 381
SS-Chr 16BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 9 -5.36 mmHg 1.72 5.17 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19641 381
SS/JrHsdMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 %change=VE during7-9 min hypoxia/control during standard conditions 149.62 % 9.13 34.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17913 381
FHH/EurMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during7-9 min hypoxia/control during standard conditions 135.33 % 11.27 33.81 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17919 381
SS-Chr 18BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 -47.52 mmHg 1.07 2.61 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 17934 381
Hsd:SD absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 16 -0.86 degrees C 0.24 0.97 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20672 381
WKY/NCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 11 -48.24 mmHg 2.65 8.8 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20685 381
LEW/Crl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 12 -47.87 mmHg 1.66 5.76 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20687 381
SS-Chr 18BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 7.52 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17609 381
SS-Chr 16BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 139.26 breaths/min 11.69 30.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17685 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 148.67 breaths/min 5.94 18.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17693 381
GH/OmrMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 8 37.39 degrees C 0.3 0.86 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17721 381
FHH/EurMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 37.15 degrees C 0.16 0.54 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17723 381
SS-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 51.61 ml/min 4.67 14.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18066 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 41.32 ml/min 4.91 14.72 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 18070 381
F344/DuCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 7.54 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18098 381
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 11 430.16 beats/min 6.98 23.14 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18101 381
SS-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 408.74 beats/min 22.8 60.31 vascular fluid filled catheter 0 Moms and pups used in studies were fed Dyets 18103 381
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 133.26 breaths/min 6.2 13.86 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17556 381
F344/DuCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 142.68 breaths/min 11.8 47.19 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17559 381
FHH-Chr 13BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 422.5 U/l 13.35 42.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36439 401
FHH/EurMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 50 390.88 U/l 9.22 65.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36442 401
FHH-Chr 3BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 375.88 U/l 26.78 75.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36443 401
SS-Chr YBN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 20 208.8 U/l 6.19 27.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36445 401
SS/JrHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 96 231.75 U/l 4.04 39.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36446 401
SS/JrHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 149.0 U/l 4.94 15.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36451 401
SS-Chr 4BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 29 139.97 U/l 3.82 20.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36454 401
BN/NHsdMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 17 125.94 U/l 4.8 19.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36458 401
FHH-Chr 7BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 339.0 U/l 16.09 50.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36461 401
Crl:CD(SD) serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 9 73.22 mg/dl 3.53 10.6 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36464 401
FHH-Chr 6BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 5.17 g/dl 0.05 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36951 401
WKY/NCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 51.48 ml/min 3.04 12.17 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18961 381
F344/DuCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 16 40.16 ml/min 2.86 11.45 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18965 381
WKY/NCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 20 40.07 ml/min 2.28 10.19 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18969 381
WKY/NCrl serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 9 5.69 g/dl 0.11 0.32 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36268 401
WKY/NCrl mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 59.41 fl 0.65 1.83 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36285 401
Crl:CD(SD) serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 9 166.67 mg/dl 7.66 22.99 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36321 401
LE/BluGill serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 162.7 mg/dl 4.21 13.33 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36328 401
LEW/Crl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 63.73 % 1.34 4.03 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36350 401
LE/BluGill hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 59.49 % 0.93 2.95 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36353 401
Crl:CD(SD) mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 20.86 pg 0.19 0.56 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36356 401
LE/BluGill mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 19.26 pg 0.15 0.46 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36359 401
SS-Chr 20BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 27 138.37 U/l 4.76 24.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36381 401
FHH-Chr 8BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 10 384.2 U/l 13.32 42.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36384 401
SS-Chr 13BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 12 145.25 U/l 7.61 26.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36386 401
SS-Chr 2BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 160.9 U/l 9.51 30.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36402 401
GH/OmrMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 16 243.88 U/l 8.6 34.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36423 401
SS-Chr 17BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 143.5 U/l 13.53 38.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36426 401
GH/OmrMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 18 360.72 U/l 5.19 22.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36428 401
SS-Chr 20BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 34 6.07 g/dl 0.08 0.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36973 401
FHH-Chr 4BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 5.05 g/dl 0.13 0.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36978 401
SS-Chr 19BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 5.35 g/dl 0.1 0.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36984 401
SS-Chr 2BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 15 6.51 g/dl 0.13 0.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36989 401
SS-Chr 9BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 18 5.98 g/dl 0.14 0.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36999 401
SS-Chr 6BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 6.31 g/dl 0.15 0.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37000 401
FHH-Chr 14BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 4.74 g/dl 0.12 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37003 401
GH/OmrMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 16 6.21 g/dl 0.1 0.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37006 401
SS-Chr 7BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 11 6.02 g/dl 0.1 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37007 401
SS-Chr 3BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 6 5.27 g/dl 0.11 0.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37023 401
SS/JrHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 96 6.07 g/dl 0.04 0.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37029 401
SS-Chr 1BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 6 5.45 g/dl 0.09 0.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37030 401
SS-Chr 4BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 29 5.91 g/dl 0.06 0.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37037 401
FHH-Chr 7BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 5.24 g/dl 0.05 0.15 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37039 401
BN/NHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 20 5.76 g/dl 0.07 0.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37040 401
SS/JrHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 4 19.75 mmol/l 1.93 3.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37045 401
SS/JrHsdMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 7 18.86 mmol/l 1.47 3.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37050 401
FHH-Chr 6BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 10 70.0 mg/dl 1.83 5.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37086 401
Hsd:SD partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 1 49.35 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17006 381
SS-Chr 6BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 11 7.53 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17025 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 9 7.51 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17027 381
SS-Chr 10BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 4 7.53 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17033 381
FHH-Chr 17BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 7.49 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17038 381
SS-Chr 5BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 2 7.55 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17041 381
SS-Chr 3BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 2 7.52 null 0.02 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17060 381
FHH-Chr 17BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 127.07 breaths/min 3.95 13.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18312 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 114.91 breaths/min 5.08 19.67 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18318 381
FHH-Chr 19BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 14 120.49 breaths/min 5.97 22.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18323 381
FHH-Chr 3BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 145.46 breaths/min 7.57 23.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18330 381
SS-Chr 16BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 58.03 ml/min 4.03 14.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18721 381
SS-Chr YBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 52.58 ml/min 1.95 8.5 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18729 381
FHH-Chr 7BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 26.55 ml/min 2.74 7.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18745 381
SS-Chr 16BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 5 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18788 381
FHH-Chr 8BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 75.0 mg/dl 2.17 6.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37102 401
FHH-Chr 18BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 75.4 mg/dl 1.38 4.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37105 401
FHH-Chr 4BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 66.13 mg/dl 2.39 6.75 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37113 401
SS-Chr 18BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 9 71.78 mg/dl 2.31 6.92 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37114 401
SS-Chr 12BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 90.88 mg/dl 3.03 8.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37122 401
SS-Chr 2BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 15 79.93 mg/dl 1.96 7.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37124 401
FHH-Chr 5BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 68.25 mg/dl 2.09 5.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37127 401
FHH-Chr 16BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 9 86.33 mg/dl 3.35 10.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37140 401
SS-Chr 7BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 12 88.75 mg/dl 3.05 10.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37147 401
FHH/EurMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 18 70.17 mg/dl 2.03 8.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37149 401
SS-Chr 16BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 13 80.77 mg/dl 2.95 10.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37155 401
FHH-Chr 13BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 74.9 mg/dl 1.16 3.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37157 401
FHH/EurMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 50 76.3 mg/dl 1.7 12.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37160 401
FHH-Chr 11BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 9 55.78 mg/dl 4.56 13.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37170 401
BN/NHsdMcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 17 58.41 mg/dl 1.09 4.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37176 401
SS-Chr 4BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 15 109.2 breaths/min 4.12 15.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18341 381
Hsd:SD serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 16 6.31 g/dl 0.11 0.43 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37408 401
SS/JrHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 6.17 g/dl 0.1 0.32 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37411 401
WKY/NCrl serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 9 139.33 U/l 14.41 43.22 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37422 401
LE/BluGill serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 9 118.44 U/l 6.92 20.77 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37427 401
Hsd:SD serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 16 221.0 U/l 15.8 63.19 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37278 401
SS-Chr 16BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 7 9.69 mg/dl 0.12 0.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37295 401
SS/JrHsdMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 7 9.2 mg/dl 0.14 0.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37297 401
FHH-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 37.1 ml/min 3.15 9.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18717 381
FHH-Chr 6BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 1 309.1 beats/min vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17483 381
SS-Chr 9BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 11 453.24 beats/min 20.85 69.14 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17485 381
GH/OmrMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 4 429.6 beats/min 6.58 13.17 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17498 381
SS-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 9 438.83 beats/min 28.19 84.58 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17499 381
FHH-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 6 423.4 beats/min 19.24 47.14 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17513 381
FHH-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 396.11 beats/min 19.99 59.98 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17517 381
FHH-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 8 388.29 beats/min 19.22 54.36 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17519 381
FHH-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 10 403.49 beats/min 13.9 43.95 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17522 381
SS-Chr 4BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 448.23 beats/min 13.23 34.99 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17533 381
FHH-Chr 4BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 2 392.32 beats/min 63.41 89.68 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17535 381
SS-Chr 4BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 9 425.87 beats/min 11.22 33.66 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17541 381
SS-Chr 12BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 4 446.64 beats/min 26.84 53.68 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17546 381
WKY/NCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 162.42 breaths/min 5.6 22.39 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17555 381
F344/DuCrl serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 17 73.82 mg/dl 4.46 18.38 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36470 401
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 5 -45.39 mmHg 3.63 8.12 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18639 381
FHH-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 19 28.0 ml/min 0.84 3.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18647 381
FHH-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 40.62 ml/min 4.8 15.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18649 381
SS-Chr 5BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 43.46 ml/min 3.61 11.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18657 381
FHH-Chr XBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 47.39 ml/min 3.8 12.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18658 381
SS-Chr 20BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 17 46.55 ml/min 2.12 8.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18664 381
SS-Chr 13BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 41.73 ml/min 5.93 18.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18669 381
FHH-Chr 20BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 38.71 ml/min 3.64 10.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18671 381
SS-Chr 5BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.64 mg/dl 0.1 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36619 401
SS-Chr 15BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.43 mg/dl 0.15 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36628 401
FHH-Chr 1BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 15 9.12 mg/dl 0.11 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36639 401
SS-Chr 19BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.19 mg/dl 0.1 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36646 401
SS-Chr 2BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.01 mg/dl 0.11 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36647 401
FHH-Chr 5BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.51 mg/dl 0.12 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36654 401
SS-Chr 6BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.9 mg/dl 0.15 0.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36662 401
FHH-Chr 14BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 8.85 mg/dl 0.12 0.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36665 401
GH/OmrMcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 18 9.33 mg/dl 0.18 0.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36673 401
Crl:CD(SD) serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 9 8.96 mg/dl 0.21 0.64 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36717 401
LE/BluGill serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 9 7.68 mg/dl 0.5 1.5 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36720 401
Hsd:SD serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 16 9.63 mg/dl 0.17 0.7 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36729 401
FHH/EurMcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 7 337.43 U/l 18.28 48.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 36734 401
Hsd:SD serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 3 215.0 mg/dl 55.0 95.26 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36740 401
Hsd:SD percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 %change=VE during 2-3 min hypoxia/control during standard conditions 187.88 % 14.16 31.67 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19300 381
LE/BluGill percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 %change=VE during 2-3 min hypoxia/control during standard conditions 151.33 % 5.57 20.09 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19309 381
GH/OmrMcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 7 -5.0 mmHg 1.22 3.22 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 19334 381
FHH-Chr 12BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 12 -46.38 mmHg 1.86 6.45 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19436 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 9 -50.07 mmHg 3.27 9.81 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19438 381
SS-Chr 14BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 -45.0 mmHg 2.36 5.77 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19440 381
SS-Chr 6BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 11 -44.5 mmHg 2.1 6.98 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19441 381
SS-Chr 9BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 12 -47.29 mmHg 3.49 12.1 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19445 381
SS-Chr 6BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 10 -46.93 mmHg 2.24 7.09 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19446 381
SS-Chr 10BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 4 -56.27 mmHg 4.07 8.15 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19448 381
FHH-Chr 17BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 -42.29 mmHg 2.8 7.93 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19453 381
SHR/NCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 -41.72 mmHg 2.11 5.18 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19455 381
GH/OmrMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 -38.88 mmHg 3.31 5.73 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19458 381
SS-Chr 14BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 105.33 breaths/min 4.8 15.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18297 381
SS-Chr 14BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 12 117.73 breaths/min 5.19 17.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18302 381
FHH-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 36.05 ml/min 3.83 12.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20195 381
FHH-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 36.64 ml/min 3.36 10.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20200 381
SHR/NCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 20 58.79 ml/min 3.95 17.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20202 381
SS-Chr 5BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 31.66 ml/min 1.84 5.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20203 381
SS-Chr 5BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 41.93 ml/min 2.51 7.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20206 381
SS-Chr 15BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 39.15 ml/min 3.63 14.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20211 381
FHH-Chr 18BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 30.82 ml/min 1.33 3.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20216 381
SS-Chr 13BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 38.81 ml/min 5.79 17.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20220 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 45.06 ml/min 2.02 7.57 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20232 381
SS-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 26.93 ml/min 2.58 7.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20233 381
SS-Chr 14BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 34.34 ml/min 3.52 11.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20240 381
SS-Chr 17BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 32.47 ml/min 3.31 10.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20256 381
SS-Chr 7BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 34.07 ml/min 2.16 6.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20259 381
FHH-Chr 19BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 37.4 ml/min 3.33 12.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20266 381
FHH-Chr 13BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 31.58 ml/min 2.72 9.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20269 381
SS-Chr XBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 30.77 ml/min 2.88 10.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20289 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 0.18 degrees C 0.2 0.69 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20299 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 112.83 breaths/min 6.95 23.04 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18147 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 5 30.27 mmHg 0.64 1.42 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18166 381
SS-Chr 16BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 4 35.64 mmHg 0.84 1.69 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18167 381
Hsd:SD respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 5 144.23 breaths/min 7.06 15.79 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18206 381
Crl:CD(SD) respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 142.79 breaths/min 8.96 29.71 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18210 381
SS/JrHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 37.38 degrees C 0.15 0.51 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 18229 381
FHH-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 19 116.69 breaths/min 4.07 17.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18250 381
FHH-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 180.21 breaths/min 6.05 19.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18257 381
FHH-Chr XBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 158.44 breaths/min 6.39 20.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18265 381
FHH-Chr 18BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 121.98 breaths/min 3.25 9.19 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18273 381
FHH-Chr YBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 21 142.33 breaths/min 6.05 27.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18278 381
SS-Chr 19BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 156.71 breaths/min 20.04 56.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18285 381
SS-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 127.86 breaths/min 9.0 29.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18286 381
SS-Chr 19BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 156.22 breaths/min 19.02 57.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18287 381
SS-Chr 12BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 114.64 breaths/min 10.14 28.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18290 381
Crl:CD(SD) heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 5.04 g/kg 0.13 0.4 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49145 461
F344/DuCrl heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 5.67 g/kg 0.28 0.88 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49151 461
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 105.43 mmHg 6.39 16.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49158 461
FHH-Chr 8BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 0.06 degrees C 0.24 0.8 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20310 381
SS-Chr 20BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 17 -0.4 degrees C 0.15 0.62 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20311 381
SS-Chr 15BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 15 -0.09 degrees C 0.15 0.59 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20312 381
FHH-Chr 8BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 0.07 degrees C 0.14 0.41 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20314 381
FHH-Chr 18BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 -0.37 degrees C 0.29 0.99 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20319 381
SS-Chr 18BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 16 -0.24 degrees C 0.16 0.64 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20323 381
FHH-Chr 1BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 18 -0.34 degrees C 0.19 0.82 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20324 381
SS-Chr 18BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 18 -0.17 degrees C 0.14 0.58 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20326 381
FHH-Chr 15BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 0.24 degrees C 0.1 0.3 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20349 381
SS-Chr 10BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 -0.46 degrees C 0.19 0.59 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20350 381
SS-Chr 16BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 14 0.04 degrees C 0.2 0.76 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20365 381
SS-Chr 16BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 0.7 degrees C 0.17 0.61 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20368 381
FHH-Chr 3BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 0.1 degrees C 0.03 0.11 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20374 381
SS/JrHsdMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 -0.22 degrees C 0.14 0.49 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20382 381
FHH-Chr 11BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 -0.8 degrees C 0.29 0.87 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20384 381
FHH-Chr 9BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 0.44 degrees C 0.16 0.49 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20391 381
Crl:CD(SD) absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 13 -0.08 degrees C 0.19 0.69 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19156 381
LEW/Crl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 16.5 % 3.76 11.89 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49035 461
FHH/EurMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 10 -42.13 mmHg 3.04 9.6 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19466 381
SS-Chr 3BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 4 -41.7 mmHg 8.05 16.11 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19469 381
SS-Chr 15BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 2 -35.95 mmHg 5.75 8.13 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19470 381
SS-Chr 16BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 9 -45.14 mmHg 1.82 5.45 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19472 381
SS-Chr 3BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 2 -58.5 mmHg 10.7 15.13 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19475 381
FHH-Chr 20BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 -49.48 mmHg 4.51 7.82 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19476 381
SS-Chr 11BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 -42.72 mmHg 2.36 5.77 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19483 381
SS-Chr 13BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 -53.6 mmHg 2.04 5.77 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19485 381
SS/JrHsdMcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 -47.66 mmHg 2.86 8.59 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19494 381
SS-Chr 2BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 -48.02 mmHg 1.86 5.59 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19504 381
FHH-Chr 7BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 2 -43.5 mmHg 4.3 6.08 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19510 381
FHH-Chr 18BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 1116.67 s 46.15 138.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50237 461
FHH-Chr YBN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 1262.09 s 28.21 93.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50240 461
SS-Chr 2BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1140.1 s 35.39 111.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50250 461
FHH-Chr 14BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 6 1179.56 s 29.65 72.63 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50268 461
SS-Chr 16BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 22 1024.7 s 26.08 122.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50281 461
SS/JrHsdMcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 97 1043.39 s 13.19 129.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50293 461
FHH-Chr 9BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 1272.0 s 40.03 120.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50302 461
LEW/Crl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 20 -0.62 degrees C 0.18 0.83 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19160 381
F344/DuCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 18 -0.71 degrees C 0.17 0.71 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19162 381
WKY/NCrl percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 96.97 % 8.23 26.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49268 461
F344/DuCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 112.32 mmHg 13.43 40.3 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49282 461
FHH-Chr 12BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 15 891.13 s 79.07 306.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49284 461
FHH-Chr 2BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 997.6 s 39.86 126.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49286 461
FHH-Chr 12BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 12 909.5 s 58.4 202.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49290 461
SS-Chr 15BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 880.5 s 23.77 75.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49302 461
SS-Chr 13BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 19 956.68 s 47.46 206.88 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49311 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 12 917.17 s 20.67 71.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49323 461
FHH-Chr 1BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 946.07 s 60.82 192.34 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49325 461
SS-Chr 3BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 932.6 s 36.18 114.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49359 461
SS/JrHsdMcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 97 787.44 s 19.12 188.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49365 461
SS-Chr 4BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 20 868.5 s 29.95 133.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49369 461
FHH-Chr 7BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 893.2 s 72.32 228.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49380 461
FHH-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 69.74 mmHg 11.13 27.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49929 461
FHH-Chr 16BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 19 89.14 mmHg 4.58 19.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49931 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 102.61 mmHg 5.43 20.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49939 461
SS-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 78.92 mmHg 4.85 14.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49943 461
SS-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 19 95.74 mmHg 5.3 23.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49949 461
SS-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 22 95.98 mmHg 3.9 18.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49952 461
SS/JrHsdMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 90 100.65 mmHg 1.99 18.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49954 461
SS-Chr XBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 95.16 mmHg 6.24 18.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49956 461
FHH-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 102.23 mmHg 4.37 13.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49964 461
LEW/Crl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 252.33 beats/min 4.17 12.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49977 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 3 316.28 beats/min 18.91 32.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49979 461
FHH-Chr 10BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 9 23.0 mmHg 2.84 8.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49996 461
SS-Chr 18BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 14 42.14 mmHg 2.7 10.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50014 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 12 42.67 mmHg 3.27 11.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50016 461
SS-Chr 2BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 44.4 mmHg 4.13 13.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50020 461
FHH-Chr 5BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 31.8 mmHg 3.16 10.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50027 461
FHH-Chr 14BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 4 17.5 mmHg 4.09 8.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50028 461
SS-Chr 7BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 11 42.36 mmHg 3.47 11.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50042 461
SS-Chr 7BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 41.4 mmHg 3.48 11.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50046 461
FHH-Chr 13BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 42.78 mmHg 5.96 17.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50055 461
FHH/EurMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 48 33.83 mmHg 1.68 11.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50059 461
SS-Chr 11BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 25 44.2 mmHg 2.96 14.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50061 461
FHH/EurMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 14 6.49 % 2.33 8.7 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49749 461
SS-Chr 16BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 11 53.09 mmHg 3.07 10.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 49794 461
SS-Chr 16BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 49.0 mmHg 2.19 6.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 49796 461
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 61.71 mmHg 4.49 11.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 49820 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 380.39 beats/min 29.41 88.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49849 461
FHH-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 106.78 mmHg 9.73 30.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49879 461
FHH-Chr 5BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 129.0 g 3.5 11.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49497 461
FHH-Chr XBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 93.2 g 5.1 16.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49523 461
FHH-Chr XBN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 97.7 g 5.7 17.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49527 461
SS-Chr 15BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 201.1 g 6.3 19.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49535 461
SS-Chr 15BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 9 156.3 g 2.8 8.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49537 461
FHH-Chr 8BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 140.0 g 8.1 25.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49541 461
FHH-Chr 18BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 10 117.8 g 5.4 17.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49546 461
SS-Chr 13BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 19 190.9 g 6.8 29.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49552 461
FHH-Chr 11BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 117.2 g 7.8 24.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49572 461
SS-Chr 19BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 145.8 g 5.0 15.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49574 461
FHH/EurMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 7 13.77 % 4.64 12.29 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 49628 461
GH/OmrMcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 7 9.1 % 3.71 9.82 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 49634 461
Crl:CD(SD) percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 67.51 % 6.43 20.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49653 461
Hsd:SD percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 2 post-ischemic value/pre-ischemic value x 100% 84.42 % 22.3 31.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49656 461
Hsd:SD time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 13 1034.7 s 53.29 192.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49663 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 7 0.35 IU/g 0.06 0.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 49676 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 0.37 IU/g 0.07 0.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 49680 461
FHH-Chr 12BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 11 8.86 % 3.33 11.03 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49689 461
SS-Chr 15BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 9 21.34 % 1.21 3.63 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49701 461
SS-Chr 13BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 19 13.96 % 2.84 12.36 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49705 461
FHH-Chr YBN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 11 9.53 % 2.47 8.18 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49711 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 11 29.88 % 3.92 12.99 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49722 461
SS-Chr 14BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 19 18.05 % 2.18 9.5 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49734 461
SS-Chr 10BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 17.42 % 4.64 14.67 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49738 461
SS-Chr 4BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 19 43.21 mmHg 2.94 12.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50071 461
BN/NHsdMcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 23 33.83 mmHg 1.95 9.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50075 461
WKY/NCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 9 146.7 g 3.9 11.8 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50079 461
LE/BluGill body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 9 292.8 g 21.7 65.1 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50088 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 0.19 IU/g 0.03 0.09 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 50092 461
FHH-Chr 12BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 16 1196.63 s 65.49 261.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50212 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 1130.56 s 41.48 155.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50217 461
SHR/NCrl time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 987.15 s 84.11 265.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50221 461
SS-Chr 15BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 1079.1 s 26.16 82.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50230 461
SS-Chr 13BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 21 1227.29 s 32.5 148.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50234 461
FHH-Chr 12BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 12 55.69 mmHg 1.25 4.32 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20447 381
FHH-Chr 6BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 1 63.1 mmHg automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20450 381
FHH-Chr 17BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 52.75 mmHg 2.36 6.68 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20465 381
SS-Chr 7BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 60.39 mmHg 2.66 7.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20471 381
SS-Chr 15BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 2 69.8 mmHg 5.9 8.34 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20482 381
SS-Chr 3BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 2 61.05 mmHg 2.85 4.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20487 381
FHH-Chr 20BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 55.26 mmHg 2.42 6.39 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20492 381
SS-Chr 11BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 60.73 mmHg 1.9 4.66 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20499 381
SS-Chr 12BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 3 60.38 mmHg 2.09 3.62 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20518 381
FHH-Chr 1BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 61.21 mmHg 0.96 2.71 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20524 381
SS-Chr 18BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.06 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20542 381
SS-Chr 16BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20543 381
BN/NHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 0.05 null 0.02 0.05 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20546 381
SS/JrHsdMcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20547 381
FHH-Chr 6BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 9 52.89 % 0.72 2.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38980 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 53.86 % 1.7 5.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38981 401
FHH-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 56.6 % 1.01 2.84 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38983 401
SS-Chr 5BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 54.24 % 0.54 1.53 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38986 401
SHR/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 15 55.04 % 0.89 3.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38988 401
FHH-Chr 8BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 52.84 % 0.8 2.53 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38992 401
FHH-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 52.82 % 0.71 2.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38999 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 58.75 % 0.96 2.71 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39010 401
SS-Chr 19BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 53.48 % 0.49 1.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39013 401
FHH-Chr 15BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 54.14 % 1.65 4.65 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39030 401
FHH-Chr 8BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 56.36 fl 0.26 0.83 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38750 401
FHH-Chr 20BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 54.51 fl 3.97 12.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38751 401
FHH-Chr 18BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 57.49 fl 0.44 1.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38753 401
SS-Chr 18BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 62.4 fl 0.45 1.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38759 401
FHH-Chr 1BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 13 58.02 fl 0.58 2.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38760 401
SS-Chr 12BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 7 63.31 fl 0.39 1.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38770 401
SS-Chr 6BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 63.48 fl 0.24 0.69 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38778 401
SS-Chr 9BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 17 61.28 fl 0.32 1.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38779 401
SS-Chr 14BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 20 59.66 fl 0.21 0.94 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38781 401
FHH-Chr 14BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 57.73 fl 0.38 1.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38786 401
SS-Chr 7BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 12 62.35 fl 0.34 1.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38795 401
FHH-Chr 19BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 59.38 fl 0.33 1.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38802 401
FHH-Chr 7BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 10 58.88 fl 0.26 0.82 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38822 401
SS-Chr XBN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 10 60.53 fl 0.49 1.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38825 401
SS-Chr 20BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 58.11 % 1.44 4.07 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38852 401
SS/JrHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 18.6 g/dl 0.56 1.67 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38873 401
SS/JrHsdMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 18.21 g/dl 0.31 0.97 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38877 401
FHH-Chr 15BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.33 g/dl 0.09 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42272 401
SS-Chr 10BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 4.02 g/dl 0.06 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42273 401
FHH-Chr 13BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.97 g/dl 0.04 0.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42292 401
FHH-Chr 11BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.6 g/dl 0.09 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42307 401
SS-Chr 16BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 6 8.57 mg/dl 0.61 1.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42318 401
SS-Chr 20BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 7 38.57 U/l 2.2 5.83 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42340 401
SS-Chr 20BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 37.38 U/l 3.7 10.47 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42343 401
F344/DuCrl serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 18 258.22 U/l 12.53 53.15 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42349 401
F344/DuCrl serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 17 254.24 U/l 11.22 46.27 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42354 401
F344/DuCrl blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 12 0.84 x 1000 cells/ul 0.05 0.18 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42374 401
SS-Chr 16BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 6 4.22 g/dl 0.08 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42395 401
FHH/EurMcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 18 16.17 mmol/l 0.75 3.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42114 401
SS-Chr 16BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 16 16.31 mmol/l 0.87 3.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42117 401
SS-Chr 11BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 17 19.82 mmol/l 0.8 3.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42124 401
SS-Chr XBN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 11 20.82 mmol/l 1.19 3.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42131 401
SS-Chr XBN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 21.0 mmol/l 0.56 1.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42142 401
FHH-Chr 7BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 10 17.5 mmol/l 0.82 2.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42144 401
Hsd:SD serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 16 92.06 U/l 5.43 21.71 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42171 401
SS/JrHsdMcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 7 5.97 g/dl 0.17 0.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 42195 401
FHH-Chr 12BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 12 3.91 g/dl 0.03 0.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42218 401
FHH-Chr 2BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.63 g/dl 0.06 0.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42225 401
FHH-Chr XBN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.4 g/dl 0.13 0.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42229 401
FHH-Chr 8BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.88 g/dl 0.04 0.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42234 401
SS-Chr 13BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 12 4.18 g/dl 0.03 0.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42240 401
SS-Chr 18BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 9 4.09 g/dl 0.06 0.18 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42250 401
GH/OmrMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 12 60.03 % 1.06 3.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39035 401
FHH-Chr 19BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 54.49 % 0.47 1.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39044 401
FHH-Chr 19BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 50.75 % 0.9 2.86 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39048 401
SS-Chr XBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 11 55.15 % 0.7 2.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39060 401
FHH-Chr 7BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 52.25 % 0.56 1.78 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39068 401
LEW/Crl serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 5.54 mmol/l 0.23 0.62 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39098 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 14 106.79 mmol/l 0.49 1.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39103 401
SHR/NCrl serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 17 108.41 mmol/l 0.67 2.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39114 401
SS-Chr 5BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 7 106.86 mmol/l 1.16 3.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39115 401
SS-Chr 15BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 108.4 mmol/l 0.4 1.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39120 401
FHH-Chr 8BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 105.2 mmol/l 0.83 2.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39122 401
FHH-Chr 18BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 109.0 mmol/l 0.56 1.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39125 401
FHH-Chr 20BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 10 108.3 mmol/l 0.76 2.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39126 401
SS-Chr 13BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 11 109.73 mmol/l 1.0 3.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39129 401
SS-Chr 19BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 106.1 mmol/l 0.35 1.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39137 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 11 108.27 mmol/l 0.74 2.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39141 401
SS-Chr 2BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 15 107.13 mmol/l 1.29 5.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39144 401
SS-Chr 19BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.82 g/dl 0.02 0.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42253 401
SS-Chr 12BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 4.05 g/dl 0.03 0.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42258 401
SS-Chr 10BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 3.72 g/dl 0.08 0.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42262 401
SS-Chr 14BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 17 3.76 g/dl 0.03 0.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42265 401
FHH-Chr XBN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 56.96 fl 0.16 0.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38741 401
FHH-Chr 10BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 57.48 fl 0.33 0.94 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38744 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 14 19.5 mmol/l 0.91 3.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42048 401
FHH-Chr XBN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 7 21.29 mmol/l 0.68 1.8 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42062 401
SS-Chr 20BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 27 19.07 mmol/l 0.48 2.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42064 401
SS-Chr 13BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 12 15.0 mmol/l 0.78 2.7 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42069 401
FHH-Chr 4BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 19.75 mmol/l 1.4 3.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42078 401
SS-Chr 12BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 22.0 mmol/l 0.5 1.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42087 401
SS-Chr 6BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 9 18.44 mmol/l 0.67 2.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42095 401
SS/JrHsdMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 90 9.36 x 10E6 cells/ul 0.05 0.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39304 401
SS-Chr 1BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 6 8.91 x 10E6 cells/ul 0.08 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39307 401
BN/NHsdMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 15 9.36 x 10E6 cells/ul 0.07 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39315 401
SS/JrHsdMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 4 185.5 mg/dl 14.54 29.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39320 401
SS-Chr 16BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 7 176.86 mg/dl 5.38 14.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 39323 401
Hsd:SD serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 16 4.46 mmol/l 0.13 0.53 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39333 401
Hsd:SD serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 18 4.13 mmol/l 0.08 0.35 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39335 401
SS/JrHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.14 mmol/l 0.29 0.93 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39336 401
Crl:CD(SD) serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.6 mg/dl 0.13 0.36 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42522 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 14 19.34 pg 0.28 1.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42531 401
GH/OmrMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 18 108.44 mmol/l 0.74 3.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39166 401
SS-Chr 3BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 7 109.14 mmol/l 0.7 1.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39173 401
FHH-Chr 13BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 10 108.9 mmol/l 0.48 1.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39177 401
SS-Chr 11BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 17 108.88 mmol/l 1.32 5.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39179 401
FHH-Chr 3BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 109.0 mmol/l 1.34 3.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39181 401
BN/NHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 20 110.25 mmol/l 0.58 2.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39195 401
BN/NHsdMcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 17 110.65 mmol/l 0.74 3.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39196 401
WKY/NCrl serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.81 g/dl 0.07 0.21 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39212 401
FHH-Chr 12BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 11 9.93 x 10E6 cells/ul 0.12 0.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39228 401
FHH-Chr XBN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 7 8.85 x 10E6 cells/ul 0.18 0.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39237 401
SS-Chr 15BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 8.85 x 10E6 cells/ul 0.18 0.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39240 401
FHH-Chr 18BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 9.19 x 10E6 cells/ul 0.15 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39245 401
SS-Chr 20BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 33 8.96 x 10E6 cells/ul 0.15 0.84 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39248 401
SS-Chr 18BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 8.53 x 10E6 cells/ul 0.36 1.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39251 401
SS-Chr 18BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 9.19 x 10E6 cells/ul 0.11 0.32 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39254 401
SS-Chr 12BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 7 8.49 x 10E6 cells/ul 0.13 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39262 401
FHH-Chr 5BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 8.51 x 10E6 cells/ul 0.16 0.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39267 401
SS-Chr 10BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 10 9.08 x 10E6 cells/ul 0.16 0.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39277 401
FHH-Chr 14BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 9.28 x 10E6 cells/ul 0.25 0.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39278 401
FHH-Chr 17BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 6 9.4 x 10E6 cells/ul 0.1 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39283 401
GH/OmrMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 16 9.7 x 10E6 cells/ul 0.1 0.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39286 401
FHH-Chr 16BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 9 9.5 x 10E6 cells/ul 0.07 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39288 401
FHH/EurMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 16 9.28 x 10E6 cells/ul 0.14 0.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39289 401
FHH/EurMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 18 141.33 mmol/l 0.86 3.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39440 401
SS-Chr 1BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 6 141.83 mmol/l 0.7 1.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39456 401
FHH-Chr 11BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 140.1 mmol/l 0.55 1.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39462 401
FHH-Chr 7BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 10 140.8 mmol/l 0.77 2.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39465 401
BN/NHsdMcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 17 143.82 mmol/l 0.52 2.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39467 401
SS-Chr 16BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 18.36 g/dl 0.3 0.8 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 39476 401
FHH/EurMcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 18.71 g/dl 0.64 1.69 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 39477 401
F344/DuCrl total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 12 4.15 x 1000 cells/ul 0.28 0.97 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39497 401
LE/BluGill total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 4.39 x 1000 cells/ul 0.22 0.7 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39498 401
LEW/Crl serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 10 17.3 mg/dl 0.94 2.98 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39512 401
WKY/NCrl serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 9 19.11 mg/dl 0.82 2.47 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39518 401
Hsd:SD total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 15 7.95 x 1000 cells/ul 0.63 2.44 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39547 401
SS/JrHsdMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 5.29 x 1000 cells/ul 0.44 1.38 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 39550 401
SS-Chr 10BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 19.42 pg 0.23 0.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42574 401
FHH-Chr 5BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 18.83 pg 0.14 0.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42575 401
FHH-Chr 14BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 18.64 pg 0.08 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42576 401
SS-Chr 6BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 20.44 pg 0.2 0.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42578 401
SS-Chr 9BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 17 19.74 pg 0.12 0.48 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42579 401
FHH-Chr 16BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 19.16 pg 0.12 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42588 401
FHH-Chr 17BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 6 18.47 pg 0.11 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42591 401
GH/OmrMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 16 19.88 pg 0.1 0.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42594 401
SS-Chr 7BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 20.53 pg 0.16 0.54 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42595 401
FHH-Chr 3BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 18.5 pg 0.07 0.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42599 401
SS-Chr 16BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 13 20.38 pg 0.23 0.84 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42603 401
SS/JrHsdMcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 90 19.92 pg 0.08 0.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42612 401
SS-Chr XBN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 20.2 pg 0.13 0.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42625 401
FHH-Chr 7BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 18.78 pg 0.17 0.54 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42627 401
FHH-Chr 12BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 12 0.26 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39561 401
WKY/NCrl mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 32.65 g/dl 0.2 0.56 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42729 401
Crl:CD(SD) mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 32.72 g/dl 0.07 0.2 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42731 401
F344/DuCrl mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 14 32.36 g/dl 0.17 0.65 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42732 401
FHH-Chr 2BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 79.25 U/l 3.31 9.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42757 401
SS-Chr 20BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 34 72.71 U/l 1.9 11.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42781 401
FHH-Chr 4BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 86.88 U/l 2.55 7.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42786 401
SS-Chr 12BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 97.0 U/l 10.6 29.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42791 401
SS-Chr 6BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 9 97.67 U/l 14.95 44.84 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42803 401
SS-Chr 14BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 20 70.8 U/l 3.33 14.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42806 401
SS-Chr 16BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 15 74.87 U/l 2.87 11.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42825 401
SS-Chr 11BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 15 82.47 U/l 7.16 27.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42835 401
FHH-Chr 9BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 7 110.57 U/l 6.92 18.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42846 401
BN/NHsdMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 17 101.29 U/l 8.24 33.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42849 401
WKY/NCruk hematocrit controlled air oxygen content (10 %) (for 21 days) Zhao L et al., 2001, Circulation, 103(3), 442-7 erythrocyte quantity male 105 days 28 median 71.0 % hematocrit analysis 0 0 66134 102
SS-Chr 14BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 17 108.0 mmol/l 0.45 1.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39149 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 14 145.29 mmol/l 0.91 3.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39374 401
SHR/NCrl serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 20 141.75 mmol/l 0.58 2.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39382 401
SS-Chr 5BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 141.5 mmol/l 1.05 2.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39383 401
SS-Chr 12BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 142.5 mmol/l 0.68 1.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39413 401
FHH-Chr 5BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 141.38 mmol/l 0.38 1.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39418 401
SS-Chr 17BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 145.5 mmol/l 1.0 2.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39430 401
SHR/NCrl plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 17 0.27 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39573 401
FHH-Chr 20BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.23 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39585 401
FHH-Chr 4BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.41 mg/dl 0.01 0.04 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39592 401
SS-Chr 19BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.38 mg/dl 0.02 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39598 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 11 0.34 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39600 401
SS-Chr 12BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.4 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39601 401
FHH-Chr 15BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.25 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39604 401
FHH-Chr 5BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.33 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39606 401
SS-Chr 6BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 9 0.31 mg/dl 0.02 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39609 401
FHH-Chr 14BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.3 mg/dl 0.03 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39617 401
GH/OmrMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 18 0.37 mg/dl 0.02 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39625 401
FHH/EurMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 51 0.33 mg/dl 0.01 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39639 401
SS/JrHsdMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 96 0.28 mg/dl 0.01 0.11 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39643 401
FHH-Chr 11BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 10 0.34 mg/dl 0.03 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39650 401
BN/NHsdMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 17 0.25 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39655 401
SS-Chr XBN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.28 mg/dl 0.02 0.06 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39656 401
FHH-Chr 12BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 12 0.11 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39659 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 14 0.36 x 1000 cells/ul 0.07 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39660 401
FHH-Chr 6BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 9 0.31 x 1000 cells/ul 0.06 0.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39663 401
FHH-Chr 2BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.29 x 1000 cells/ul 0.07 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39666 401
FHH-Chr XBN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.36 x 1000 cells/ul 0.05 0.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39670 401
SHR/NCrl blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 15 0.25 x 1000 cells/ul 0.06 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39671 401
SS-Chr 15BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.27 x 1000 cells/ul 0.09 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39678 401
FHH-Chr 8BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.26 x 1000 cells/ul 0.06 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39679 401
SS-Chr 13BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 12 0.33 x 1000 cells/ul 0.06 0.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39681 401
FHH-Chr 18BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 10 0.36 x 1000 cells/ul 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39684 401
FHH-Chr 4BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 7 0.18 x 1000 cells/ul 0.03 0.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39692 401
SS-Chr 20BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.63 g/dl 0.08 0.21 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42964 401
SS/JrHsdMcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 10 3.93 g/dl 0.08 0.26 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 42966 401
FHH-Chr 20BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.97 x 1000 cells/ul 0.16 0.5 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43233 401
SS-Chr 12BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 7 0.66 x 1000 cells/ul 0.15 0.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43249 401
SS-Chr 2BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 15 1.37 x 1000 cells/ul 0.2 0.76 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43251 401
FHH-Chr 15BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 1.27 x 1000 cells/ul 0.22 0.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43263 401
GH/OmrMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 16 1.0 x 1000 cells/ul 0.15 0.6 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43273 401
SS-Chr 16BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 15 0.6 x 1000 cells/ul 0.07 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43279 401
FHH-Chr 19BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.65 x 1000 cells/ul 0.09 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43281 401
LE/BluGill percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 149.13 % 14.1 44.58 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54524 381
Crl:CD(SD) percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 131.32 % 6.81 24.57 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54526 381
WKY/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 16 121.54 % 3.52 14.1 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54528 381
Hsd:SD serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 16 75.13 mg/dl 2.81 11.22 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43104 401
FHH-Chr 2BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 1.01 x 1000 cells/ul 0.31 0.88 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43211 401
SS-Chr 1BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 6 32.02 g/dl 0.38 0.93 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39845 401
SS-Chr 4BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 27 32.32 g/dl 0.11 0.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39848 401
SS-Chr 4BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 29 32.4 g/dl 0.13 0.68 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39852 401
FHH-Chr 9BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 6 32.35 g/dl 0.13 0.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39858 401
SS-Chr 13BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 32.57 g/dl 0.33 1.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39789 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 31.89 g/dl 0.16 0.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39796 401
SS-Chr 12BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 32.44 g/dl 0.4 1.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39802 401
SS-Chr 14BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 17 32.04 g/dl 0.09 0.36 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39809 401
SS-Chr 6BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 32.16 g/dl 0.24 0.69 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39810 401
SS-Chr 14BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 20 32.16 g/dl 0.1 0.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39813 401
FHH-Chr 14BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 31.75 g/dl 0.16 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39818 401
GH/OmrMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 32.68 g/dl 0.18 0.63 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39821 401
FHH-Chr 16BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 31.86 g/dl 0.12 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39828 401
SS-Chr 16BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 15 32.42 g/dl 0.22 0.85 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39832 401
SS-Chr 3BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 7 32.47 g/dl 0.25 0.67 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39833 401
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 7 104.84 % 4.35 11.5 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 54301 381
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 117.5 % 3.25 12.57 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 54304 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 116.53 % 3.75 12.43 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 54305 381
LEW/Crl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 1 124.43 % stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 54321 381
FHH-Chr XBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 134.25 % 8.73 27.6 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54326 381
FHH-Chr 8BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 139.27 % 6.5 21.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54328 381
FHH-Chr 20BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 124.66 % 4.58 13.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54333 381
SS-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 115.71 % 6.49 22.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54351 381
FHH-Chr 5BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 145.82 % 8.95 28.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54362 381
SS-Chr 6BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 17 125.86 % 5.74 23.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54360 381
FHH-Chr 17BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 126.2 % 3.86 12.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54372 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 138.93 % 10.15 32.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54377 381
FHH-Chr 13BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 131.97 % 8.33 26.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54385 381
SS-Chr 11BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 118.04 % 6.46 20.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54388 381
SS-Chr 11BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 135.12 % 10.11 30.33 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54390 381
SS-Chr XBN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 140.93 % 6.44 22.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54395 381
FHH-Chr 9BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 123.88 % 4.99 15.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54402 381
SHR/NCrl plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 20 0.33 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39570 401
FHH-Chr 5BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.37 x 1000 cells/ul 0.08 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39709 401
SS-Chr 7BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 11 0.51 x 1000 cells/ul 0.06 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39719 401
FHH-Chr 16BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 9 0.19 x 1000 cells/ul 0.07 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39725 401
FHH-Chr 19BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 10 0.27 x 1000 cells/ul 0.09 0.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39727 401
FHH-Chr 9BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 6 0.35 x 1000 cells/ul 0.1 0.24 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39755 401
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 107.5 % 6.97 20.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54543 381
SHR/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 91.27 % 2.44 7.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 54553 381
Hsd:SD percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 108.45 % 3.59 13.89 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 54568 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 134.27 % 7.41 24.57 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53537 381
BN/NHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 107.62 % 6.63 18.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53550 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 111.46 % 4.4 14.59 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53575 381
SS-Chr 16BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 5 98.15 % 3.65 8.17 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53576 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 11 140.04 % 11.02 36.55 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 53591 381
LEW/Crl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 123.5 % 6.41 27.19 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53596 381
LEW/Crl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 20 112.93 % 3.45 15.42 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53608 381
Hsd:SD serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 5 26.6 mg/dl 1.69 3.78 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 39986 401
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 135.48 % 7.8 24.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53725 381
SS/JrHsdMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 14 146.87 % 5.67 21.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53730 381
FHH/EurMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 112.07 % 7.16 22.65 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 53732 381
FHH-Chr 6BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 11 130.67 % 11.42 37.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53738 381
SS/JrHsdMcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.49 x 1000 cells/ul 0.13 0.4 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 43410 401
FHH/EurMcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 7 138.0 U/l 35.86 94.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 43415 401
SS/JrHsdMcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.43 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 58885 526
SHR/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 15 1.68 mg/kg 0.23 0.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58900 526
SS-Chr 18BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 1.22 mg/kg 0.29 0.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58920 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.79 mg/kg 0.27 0.84 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58930 526
FHH-Chr 1BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 2.96 mg/kg 1.01 3.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58932 526
FHH-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 1.63 mg/kg 0.32 0.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58936 526
FHH-Chr 3BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 3.32 mg/kg 0.82 2.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58970 526
SS-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 14 1.49 mg/kg 0.23 0.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58971 526
SS/JrHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 18.46 ml/min/kg 3.17 7.78 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59026 526
FHH-Chr 6BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 161.0 g 2.1 6.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59051 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 176.4 g 3.1 10.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59052 526
FHH-Chr 10BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 128.3 g 5.8 18.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59055 526
FHH-Chr 20BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 193.2 g 4.2 13.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59068 526
SS-Chr 19BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 237.8 g 7.3 22.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59082 526
FHH-Chr 14BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 103.8 g 4.0 12.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59093 526
SS-Chr 6BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 9 224.3 g 10.4 31.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59100 526
SS-Chr 17BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 169.7 g 2.7 8.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59109 526
SS/JrHsdMcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 116 242.1 g 2.6 28.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59129 526
FHH-Chr 7BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 206.4 g 11.8 37.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59144 526
Hsd:SD heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 8 0.37 null 0.02 0.05 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 59145 526
SS-Chr 1BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 6 0.93 x 1000 cells/ul 0.12 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43292 401
FHH-Chr 11BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 9 0.64 x 1000 cells/ul 0.1 0.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43297 401
FHH-Chr 11BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 10 0.57 x 1000 cells/ul 0.08 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43298 401
FHH-Chr 9BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 5 0.8 x 1000 cells/ul 0.15 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43300 401
FHH-Chr 9BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 6 1.13 x 1000 cells/ul 0.16 0.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43305 401
FHH/EurMcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 7 0.43 mg/dl 0.04 0.1 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Dyets 40378 401
SS-Chr 16BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 6 0.52 x 1000 cells/ul 0.09 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 40385 401
FHH-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 2.34 mg/kg 0.46 1.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58988 526
SS-Chr 11BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 15 52.9 % 0.89 3.43 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59322 526
SS-Chr XBN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 55.54 % 0.64 2.01 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59326 526
SS-Chr 4BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 20 54.61 % 0.63 2.82 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59328 526
BN/NHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 17 54.05 % 0.45 1.85 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59336 526
FHH-Chr 7BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 55.68 % 0.65 2.06 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59339 526
Crl:CD(SD) serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 9 0.22 mg/dl 0.02 0.07 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37545 401
WKY/NCrl plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 20.7 mmol/l 1.73 5.48 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37551 401
LE/BluGill plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 9 24.22 mmol/l 0.64 1.92 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37556 401
WKY/NCrl plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 9 19.0 mmol/l 0.29 0.87 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37558 401
Hsd:SD serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 5 0.34 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37577 401
Hsd:SD serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 3 0.33 mg/dl 0.09 0.15 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37578 401
Hsd:SD serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 16 2.26 g/dl 0.08 0.34 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40497 401
Crl:CD(SD) blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 9 0.07 x 1000 cells/ul 0.02 0.05 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40505 401
WKY/NCrl blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 9 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40508 401
SS-Chr 20BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 5.62 x 1000 cells/ul 0.77 2.18 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40511 401
SS/JrHsdMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 4.55 x 1000 cells/ul 0.41 1.29 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40516 401
FHH-Chr 6BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.59 g/dl 0.03 0.11 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40538 401
FHH-Chr 6BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.35 g/dl 0.02 0.07 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40539 401
FHH-Chr 10BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.27 g/dl 0.08 0.23 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40543 401
SHR/NCrl serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 20 2.1 g/dl 0.03 0.15 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40544 401
FHH-Chr XBN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 7 1.16 g/dl 0.04 0.11 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40550 401
FHH-Chr YBN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 9 1.47 g/dl 0.03 0.1 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40563 401
SS-Chr 12BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.7 g/dl 0.07 0.19 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40571 401
SS-Chr 10BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 10 1.73 g/dl 0.06 0.18 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40579 401
SS-Chr 9BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 18 2.12 g/dl 0.05 0.23 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40587 401
SS-Chr 6BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 2.61 g/dl 0.08 0.22 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40588 401
FHH-Chr 16BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 9 1.53 g/dl 0.09 0.27 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40593 401
SS-Chr 7BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 11 2.38 g/dl 0.07 0.23 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40595 401
FHH-Chr 17BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 6 1.25 g/dl 0.04 0.1 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40598 401
FHH-Chr 16BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 9 1.72 g/dl 0.03 0.08 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40601 401
FHH-Chr 3BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.65 g/dl 0.06 0.16 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40604 401
FHH-Chr 13BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 10 1.33 g/dl 0.04 0.12 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40609 401
SS/JrHsdMcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 96 2.36 g/dl 0.04 0.34 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40617 401
LEW/Crl blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 9 0.32 x 1000 cells/ul 0.08 0.24 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40690 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 56.23 % 0.79 2.23 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59247 526
FHH-Chr 20BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 51.14 % 0.58 1.85 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59266 526
SS-Chr 18BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 9 55.54 % 0.67 2.0 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59271 526
FHH-Chr 4BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 51.78 % 1.32 3.73 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59273 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 58.75 % 0.96 2.71 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59276 526
SS-Chr 19BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 10 56.92 % 0.69 2.18 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59277 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 11 59.51 % 0.47 1.55 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59281 526
FHH-Chr 5BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 51.0 % 1.16 3.29 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59287 526
SS-Chr 6BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 57.04 % 0.6 1.7 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59290 526
SS-Chr 6BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 7 61.0 % 1.05 2.77 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59295 526
GH/OmrMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 20 58.51 % 0.62 2.77 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59306 526
SS-Chr 7BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 12 53.23 % 0.59 2.04 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59307 526
FHH-Chr 3BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 49.13 % 1.7 4.8 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59311 526
SS-Chr 16BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 15 58.62 % 0.59 2.27 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59312 526
FHH-Chr 13BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 10 49.64 % 0.5 1.58 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59316 526
SS-Chr 14BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 20 6.66 x 1000 cells/ul 0.49 2.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40962 401
FHH-Chr 15BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 9.35 x 1000 cells/ul 1.09 3.09 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40965 401
FHH-Chr 17BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 6 4.83 x 1000 cells/ul 0.58 1.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40974 401
FHH-Chr 3BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 6.5 x 1000 cells/ul 0.54 1.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40980 401
SS-Chr 16BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 15 5.08 x 1000 cells/ul 0.36 1.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40981 401
FHH-Chr 13BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 4.88 x 1000 cells/ul 0.28 0.89 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40985 401
BN/NHsdMcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 13 7.25 x 1000 cells/ul 0.39 1.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41005 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 13 51.62 U/l 2.03 7.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40700 401
SS-Chr 5BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 47.38 U/l 3.78 10.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40709 401
FHH-Chr 20BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 43.4 U/l 1.94 6.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40723 401
SS-Chr 20BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 34 51.41 U/l 2.02 11.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40725 401
SS-Chr 19BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 52.6 U/l 11.21 35.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40734 401
SS-Chr 12BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 44.63 U/l 5.68 16.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40739 401
FHH-Chr 14BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 83.38 U/l 4.4 12.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40745 401
FHH-Chr 14BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 97.25 U/l 9.68 27.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40755 401
SS-Chr 7BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 12 41.25 U/l 1.9 6.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40764 401
SS-Chr 16BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 16 44.75 U/l 3.37 13.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40769 401
FHH-Chr 19BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 47.0 U/l 3.03 9.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40771 401
FHH-Chr 11BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 10 42.5 U/l 3.05 9.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40788 401
SS-Chr 4BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 29 41.24 U/l 1.22 6.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40789 401
FHH-Chr 9BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 7 69.71 U/l 5.09 13.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40790 401
FHH-Chr 7BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 10 45.2 U/l 3.59 11.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40796 401
Crl:CD(SD) plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 9 0.32 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40801 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 14 19.93 mg/dl 0.68 2.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40814 401
SS-Chr 5BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 22.75 mg/dl 1.18 3.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40823 401
SS-Chr 5BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 7 21.43 mg/dl 1.25 3.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40826 401
FHH-Chr 18BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 10 20.7 mg/dl 1.0 3.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40836 401
SS-Chr 20BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 34 21.15 mg/dl 0.64 3.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40839 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 9 20.89 mg/dl 0.75 2.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40847 401
GH/OmrMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 15 22.2 mg/dl 1.01 3.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40872 401
FHH/EurMcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 18 21.5 mg/dl 0.78 3.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40880 401
SS-Chr 16BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 14 23.79 mg/dl 0.83 3.09 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40886 401
FHH-Chr 6BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 9 6.23 x 1000 cells/ul 0.39 1.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40915 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 5.34 x 1000 cells/ul 0.64 2.01 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40916 401
SHR/NCrl total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 15 4.07 x 1000 cells/ul 0.51 1.97 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40923 401
FHH-Chr 20BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 7.03 x 1000 cells/ul 0.94 2.96 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40932 401
FHH-Chr 18BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 8.22 x 1000 cells/ul 0.65 2.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40934 401
FHH-Chr YBN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 9 7.5 x 1000 cells/ul 0.32 0.96 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40939 401
SS-Chr 18BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 5.35 x 1000 cells/ul 0.55 1.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40940 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 4.86 x 1000 cells/ul 0.61 1.73 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40945 401
SS-Chr 19BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 10 8.03 x 1000 cells/ul 0.35 1.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40946 401
SS-Chr 2BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 10 5.11 x 1000 cells/ul 0.24 0.77 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40949 401
FHH-Chr 12BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 11 8.2 mg/dl 0.18 0.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37585 401
FHH-Chr 4BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 11.23 mg/dl 0.65 1.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37610 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 9 7.98 mg/dl 0.22 0.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37613 401
SS-Chr 10BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 8.6 mg/dl 0.15 0.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37634 401
FHH-Chr 16BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 9 8.08 mg/dl 0.32 0.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37645 401
FHH-Chr 3BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 6 9.07 mg/dl 0.3 0.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37658 401
SS-Chr 1BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 6 8.7 mg/dl 0.23 0.55 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37664 401
SS/JrHsdMcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 8.36 mg/dl 0.28 0.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37666 401
FHH-Chr 9BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 6 11.33 mg/dl 0.6 1.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37670 401
LE/BluGill plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 10 0.29 mg/dl 0.01 0.03 automated plasma creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40806 401
Hsd:SD serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 16 20.75 mg/dl 0.8 3.19 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 40809 401
FHH-Chr 5BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.63 g/kg 0.05 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59692 526
SS-Chr 9BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 20 1.48 g/kg 0.03 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59694 526
SS-Chr 17BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.31 g/kg 0.06 0.2 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59704 526
SS-Chr 3BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 15 1.38 g/kg 0.04 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59713 526
FHH-Chr 13BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.61 g/kg 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59716 526
SS-Chr 11BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 17 1.19 g/kg 0.04 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59722 526
SS-Chr 1BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 11 1.42 g/kg 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59727 526
FHH-Chr 7BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.9 g/kg 0.04 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59734 526
SS-Chr 20BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 5 0.8 null 0.17 0.38 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 59743 526
SS-Chr 16BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 24.24 ml/min/kg 1.74 4.26 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 59751 526
SS/JrHsdMcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 11.15 ml/min/kg 1.47 4.64 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 59754 526
SS/JrHsdMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 2 8.83 x 10E6 cells/ul 0.38 0.54 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 37915 401
SS/JrHsdMcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 3 9.33 x 10E6 cells/ul 0.14 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 37920 401
Hsd:SD serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 5 144.0 mmol/l 2.35 5.24 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37785 401
SS-Chr 20BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 63.76 fl 0.62 1.76 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37797 401
Hsd:SD mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 15 61.77 fl 0.65 2.53 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37799 401
SS-Chr 20BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 65.99 fl 1.28 3.62 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37800 401
Hsd:SD mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 16 61.14 fl 0.35 1.4 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37801 401
SS-Chr 20BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.04 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 37803 401
FHH-Chr 2BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.18 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59539 526
SS-Chr 5BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.12 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59542 526
SS-Chr 15BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.17 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59550 526
FHH-Chr 20BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.16 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59553 526
FHH-Chr 18BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.15 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59555 526
SS-Chr 18BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 18 0.18 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59561 526
Hsd:SD red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 4 9.01 x 10E6 cells/ul 0.15 0.3 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 37947 401
FHH-Chr 6BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 9 16.87 g/dl 0.22 0.66 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37957 401
FHH-Chr 10BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 7 16.87 g/dl 0.29 0.75 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37961 401
FHH-Chr XBN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 17.16 g/dl 0.65 1.85 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37964 401
FHH-Chr 10BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 17.18 g/dl 0.17 0.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37967 401
FHH-Chr 8BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 17.39 g/dl 0.29 0.92 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37973 401
FHH-Chr 1BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 13 18.48 g/dl 0.33 1.2 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37983 401
SS-Chr 9BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 17 18.44 g/dl 0.1 0.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38002 401
SS-Chr 9BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 15 18.05 g/dl 0.17 0.66 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38005 401
FHH-Chr 13BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 10 15.87 g/dl 0.16 0.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38027 401
SS-Chr 4BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 27 17.87 g/dl 0.15 0.79 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38039 401
SS-Chr 4BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 29 17.62 g/dl 0.14 0.78 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38043 401
SS-Chr 18BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 24 0.16 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59564 526
SS-Chr 19BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.13 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59569 526
FHH-Chr 5BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.16 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59577 526
SS-Chr 14BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 18 0.15 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59583 526
GH/OmrMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 30 0.17 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59591 526
SS-Chr 7BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 0.14 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59592 526
FHH-Chr 19BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.16 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59600 526
SS-Chr 16BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 14 0.18 mmHg x min x kg x ml-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59605 526
FHH-Chr 11BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 0.2 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59621 526
SS-Chr 4BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 18 0.13 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59622 526
FHH-Chr 2BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.56 g/kg 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59649 526
SS-Chr 20BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 32 1.44 g/kg 0.02 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59659 526
FHH-Chr 8BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.54 g/kg 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59662 526
FHH-Chr 18BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.71 g/kg 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59667 526
FHH-Chr 1BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 16 1.52 g/kg 0.07 0.26 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59672 526
FHH-Chr 4BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.55 g/kg 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59673 526
SS-Chr 12BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.42 g/kg 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59682 526
FHH-Chr 1BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.79 g/kg 0.05 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59683 526
SS/JrHsdMcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 9 32.14 g/dl 0.14 0.41 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41116 401
SS-Chr 20BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 32.16 g/dl 0.27 0.75 automated blood cell counting method 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 41118 401
WKY/NCrl serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 9 19.67 mmol/l 0.58 1.73 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41128 401
WKY/NCrl serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 9 3.76 g/dl 0.06 0.19 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41138 401
LE/BluGill serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 10 4.31 g/dl 0.07 0.21 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41140 401
SS/JrHsdMcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 2 6.14 x 1000 cells/ul 0.26 0.37 automated blood cell counting method 0 Moms and pups used in studies were fed Dyets 41141 401
SS/JrHsdMcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 4 33.5 U/l 2.9 5.8 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 41154 401
SS-Chr 20BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 20 4.89 mmol/l 0.16 0.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38068 401
SS-Chr 18BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 7 4.97 mmol/l 0.29 0.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38083 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 7 5.44 mmol/l 0.17 0.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38085 401
SS-Chr 14BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 16 4.51 mmol/l 0.12 0.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38098 401
SS-Chr 6BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.76 mmol/l 0.11 0.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38099 401
SS-Chr 14BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 19 5.04 mmol/l 0.18 0.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38102 401
FHH-Chr 14BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 8 5.15 mmol/l 0.24 0.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38107 401
SS-Chr 16BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 6 28.67 mg/dl 1.63 3.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 41382 401
FHH-Chr 13BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 10 15.9 mmol/l 0.28 0.88 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38320 401
SS-Chr 4BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 29 20.79 mmol/l 0.48 2.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38332 401
FHH-Chr 9BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 7 20.86 mmol/l 1.22 3.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38342 401
FHH-Chr 7BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 20.1 mmol/l 0.38 1.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38343 401
WKY/NCrl blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 19.68 g/dl 0.56 1.6 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38399 401
LEW/Crl blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 20.1 g/dl 0.34 0.95 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38400 401
F344/DuCrl blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 14 19.2 g/dl 0.28 1.03 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38402 401
F344/DuCrl blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 19.27 g/dl 0.18 0.62 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38407 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 10 4.31 x 1000 cells/ul 0.51 1.62 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41493 401
FHH-Chr 20BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 6.51 x 1000 cells/ul 0.56 1.79 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41509 401
FHH-Chr 18BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 6.61 x 1000 cells/ul 0.58 1.83 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41511 401
SS-Chr 13BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 11 5.1 x 1000 cells/ul 0.61 2.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41515 401
FHH-Chr 4BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 5.56 x 1000 cells/ul 0.76 2.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41519 401
SS-Chr 18BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 3.49 x 1000 cells/ul 0.61 1.72 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41520 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 4.0 x 1000 cells/ul 0.58 1.65 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41522 401
SS-Chr 12BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 7 6.53 x 1000 cells/ul 0.39 1.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41528 401
FHH-Chr 5BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 4.21 x 1000 cells/ul 0.21 0.59 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41533 401
SS-Chr 16BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 15 4.27 x 1000 cells/ul 0.33 1.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41558 401
FHH-Chr 13BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 4.91 x 1000 cells/ul 0.44 1.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41563 401
SS-Chr XBN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 11 6.03 x 1000 cells/ul 0.45 1.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41572 401
WKY/NCrl serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 9 52.56 U/l 4.46 13.37 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41605 401
Hsd:SD blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 4 0.06 x 1000 cells/ul 0.03 0.06 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41609 401
SS-Chr 17BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.03 mmol/l 0.09 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38113 401
FHH/EurMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 17 4.69 mmol/l 0.15 0.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38118 401
SS/JrHsdMcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 10 4.6 mmol/l 0.18 0.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38138 401
LE/BluGill red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 10 10.02 x 10E6 cells/ul 0.23 0.74 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38158 401
LEW/Crl blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 9 4.0 x 1000 cells/ul 0.25 0.74 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38215 401
F344/DuCrl blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 14 3.26 x 1000 cells/ul 0.34 1.27 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38217 401
LEW/Crl blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 3.58 x 1000 cells/ul 0.29 0.91 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38220 401
LE/BluGill blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 10 3.35 x 1000 cells/ul 0.18 0.58 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38223 401
LEW/Crl serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 10 139.6 mmol/l 0.4 1.26 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38242 401
SS-Chr 2BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 15 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41674 401
SS-Chr 6BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41680 401
FHH-Chr 5BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.12 x 1000 cells/ul 0.03 0.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41682 401
FHH-Chr 15BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41686 401
FHH-Chr 14BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.05 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41688 401
SS-Chr 17BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41694 401
GH/OmrMcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 16 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41696 401
SS-Chr 3BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 7 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41708 401
FHH-Chr 3BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.04 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41711 401
SS-Chr YBN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 20 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41713 401
FHH-Chr 7BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 10 0.04 x 1000 cells/ul 0.02 0.07 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41729 401
Hsd:SD plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 5 0.54 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 41730 401
FHH-Chr 12BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 12 159.75 mg/dl 4.42 15.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38515 401
FHH-Chr 12BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 11 150.18 mg/dl 6.18 20.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38521 401
SS.BN-(D12Arb13-D12Rat79)/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 10 0.05 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41637 401
SHR/NCrl blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 15 0.04 x 1000 cells/ul 0.01 0.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41644 401
SS-Chr 5BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 7 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41645 401
FHH-Chr 4BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.04 x 1000 cells/ul 0.02 0.06 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41663 401
SS-Chr 5BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 7 19.0 mmol/l 0.65 1.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38259 401
FHH-Chr 4BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 19.63 mmol/l 1.31 3.7 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38277 401
SS-Chr 18BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 9 17.89 mmol/l 0.79 2.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38278 401
SS.BN-(D8Rat163-D8Rat81)/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 9 26.89 mmol/l 0.82 2.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38280 401
SS-Chr 12BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 17.63 mmol/l 0.78 2.2 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38282 401
FHH-Chr 15BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 17.5 mmol/l 1.32 3.74 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38289 401
SS-Chr 10BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 18.2 mmol/l 0.57 1.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38290 401
FHH-Chr 15BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 18.25 mmol/l 1.93 5.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38300 401
GH/OmrMcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 18 24.39 mmol/l 0.61 2.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38310 401
FHH-Chr 19BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 10 17.8 mmol/l 0.57 1.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38314 401
FHH-Chr 3BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 16.63 mmol/l 0.86 2.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38315 401
SS-Chr 3BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 7 18.71 mmol/l 1.08 2.87 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38317 401
SS-Chr 10BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 0.84 g 0.06 0.17 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45434 461
SS-Chr 9BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 18 1.05 g 0.06 0.25 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45439 461
GH/OmrMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.92 g 0.04 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45449 461
FHH-Chr 13BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 1.11 g 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45464 461
FHH-Chr 3BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 0.69 g 0.06 0.17 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45468 461
SS/JrHsdMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 104 1.13 g 0.02 0.23 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45471 461
FHH-Chr 9BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.64 g 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45480 461
FHH-Chr 7BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.89 g 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45481 461
BN/NHsdMcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 23 0.59 g 0.02 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45483 461
SS-Chr XBN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 13 0.6 g 0.06 0.21 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45484 461
Hsd:SD heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 17.99 IU/g 4.36 10.69 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45487 461
FHH-Chr 20BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.39 IU/g 0.07 0.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47470 461
FHH-Chr 20BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.32 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47472 461
FHH-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.21 IU/g 0.06 0.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47474 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 49 0.27 IU/g 0.02 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47476 461
SS-Chr YBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 29 0.36 IU/g 0.03 0.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47480 461
SS-Chr 1BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.28 IU/g 0.07 0.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47484 461
FHH-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 0.32 IU/g 0.06 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47497 461
SS-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.36 IU/g 0.06 0.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47499 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 19 0.78 IU/g 0.09 0.38 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47505 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 78.72 % 11.48 32.48 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 47518 461
Hsd:SD percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 2 post-ischemic value/pre-ischemic value x 100% 52.78 % 35.43 50.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47525 461
WKY/NCrl percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 53.05 % 9.38 29.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47528 461
F344/DuCrl percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 50.46 % 11.03 33.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47530 461
LE/BluGill percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 47.41 % 8.89 23.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47531 461
GH/OmrMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 5.0 mmHg 0.17 0.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 47539 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 14 255.94 beats/min 9.61 35.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47568 461
FHH-Chr 10BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 160.5 mg/dl 7.79 22.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38529 401
SS-Chr 15BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 8 155.25 mg/dl 14.8 41.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38534 401
FHH-Chr 4BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 7 156.29 mg/dl 10.73 28.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38548 401
SS-Chr 19BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 147.8 mg/dl 3.9 12.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38550 401
FHH-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 55.82 mmHg 3.46 10.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46425 461
SS-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 41.31 mmHg 5.41 17.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46440 461
SS-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 52.86 mmHg 3.32 10.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46442 461
FHH-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 41.83 mmHg 5.18 10.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46448 461
SS-Chr 6BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 59.17 mmHg 3.27 9.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46450 461
SS-Chr 17BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 58.22 mmHg 4.42 13.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46459 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 44 54.15 mmHg 1.95 12.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46479 461
SS/JrHsdMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 16 55.26 mmHg 2.76 11.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46488 461
FHH-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 61.33 mmHg 3.94 12.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46489 461
SS-Chr 4BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 18 45.88 mmHg 3.85 16.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46491 461
FHH-Chr 9BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 41.68 mmHg 5.94 17.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46497 461
FHH-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 54.1 mmHg 2.82 8.9 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46498 461
WKY/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 183.92 beats/min 12.88 36.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46499 461
Crl:CD(SD) heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 332.0 beats/min 62.39 197.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46501 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 3 261.19 beats/min 14.7 25.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46504 461
Hsd:SD heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 2 272.73 beats/min 0.0 0.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46508 461
LE/BluGill heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 226.16 beats/min 9.33 28.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46510 461
SS-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 344.24 beats/min 24.49 77.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46515 461
GH/OmrMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 252.78 beats/min 11.94 35.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46518 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 14 59.86 fl 0.96 3.58 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38731 401
FHH-Chr 2BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 58.76 fl 0.32 0.92 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38732 401
FHH-Chr 12BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 11 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41859 401
FHH-Chr 10BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41867 401
SS-Chr 20BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 27 0.12 mg/dl 0.01 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41870 401
SS-Chr 10BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.13 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41897 401
FHH-Chr 14BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.11 mg/dl 0.01 0.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41899 401
SS-Chr 14BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 17 0.11 mg/dl 0.01 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41900 401
SS-Chr 17BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.09 mg/dl 0.01 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41910 401
FHH-Chr 17BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 6 0.08 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41914 401
SS-Chr 7BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 12 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41918 401
FHH-Chr 3BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41922 401
SS-Chr 11BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 17 0.12 mg/dl 0.01 0.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41930 401
SS-Chr YBN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 20 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41934 401
SS-Chr 4BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 29 0.13 mg/dl 0.01 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41939 401
SS-Chr 9BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 17 170.82 mg/dl 3.66 15.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38564 401
SS-Chr 6BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 157.38 mg/dl 3.39 9.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38568 401
FHH-Chr 15BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 8 145.13 mg/dl 11.21 31.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38569 401
SS-Chr 7BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 12 164.33 mg/dl 4.74 16.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38580 401
FHH/EurMcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 18 152.78 mg/dl 5.46 23.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38582 401
SS-Chr 16BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 13 153.69 mg/dl 5.17 18.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38588 401
FHH-Chr 13BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 142.4 mg/dl 3.9 12.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38590 401
SS-Chr XBN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 10 147.0 mg/dl 4.3 13.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38610 401
Hsd:SD serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 18 170.72 mg/dl 4.42 18.76 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 38627 401
SS-Chr 6BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 24.58 % 5.59 17.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48565 461
FHH-Chr 16BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 38.75 % 3.94 13.06 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48577 461
FHH-Chr 13BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 38.04 % 14.32 28.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48585 461
SS-Chr 11BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 36.89 % 2.7 10.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48591 461
FHH-Chr 9BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 42.93 % 7.66 22.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48602 461
BN/NHsdMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 22 post-ischemic value/pre-ischemic value x 100% 52.63 % 2.7 12.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48604 461
SS-Chr XBN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 61.92 % 3.66 12.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48606 461
FHH-Chr 6BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 128.99 mmHg 6.84 22.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48612 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 12 131.2 mmHg 4.31 14.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48614 461
FHH-Chr 10BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 82.65 mmHg 8.19 24.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48623 461
FHH-Chr 8BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 155.52 mmHg 6.97 15.58 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48625 461
SS-Chr 15BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 102.05 mmHg 9.24 29.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48627 461
FHH-Chr 1BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 143.14 mmHg 6.57 20.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48639 461
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 121.88 mmHg 7.81 20.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48641 461
FHH-Chr 1BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 146.91 mmHg 5.97 18.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48650 461
SS-Chr 10BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 111.48 mmHg 5.81 12.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48664 461
SS-Chr 16BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 18 102.9 mmHg 4.71 19.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48681 461
SS-Chr 1BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 94.29 mmHg 13.5 38.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48691 461
SS-Chr 1BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 97.99 mmHg 9.78 27.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48693 461
GH/OmrMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 137.0 mmHg 5.88 17.64 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48730 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 135.29 mmHg 10.69 28.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48736 461
FHH-Chr 6BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 236.68 beats/min 6.05 20.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47570 461
SHR/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 257.93 beats/min 12.49 39.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47576 461
FHH-Chr XBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 203.47 beats/min 12.82 36.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47578 461
FHH-Chr 20BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 245.4 beats/min 4.61 13.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47591 461
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 276.33 beats/min 8.47 31.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47599 461
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 209.89 beats/min 13.97 44.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47605 461
SS-Chr 14BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 17 262.63 beats/min 6.79 28.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47614 461
GH/OmrMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 209.85 beats/min 7.0 19.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47626 461
FHH-Chr 19BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 244.91 beats/min 5.23 16.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47634 461
SS/JrHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 17 285.02 beats/min 10.4 42.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47653 461
SS-Chr 16BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 69.61 % 4.04 13.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48501 461
SS-Chr 16BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 45.35 % 7.89 24.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48503 461
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 30.39 % 6.29 23.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48513 461
SS-Chr 5BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 37.36 % 4.24 12.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48522 461
SS-Chr 13BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 49.11 % 5.58 18.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48534 461
FHH-Chr YBN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 42.52 % 6.57 20.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48540 461
FHH-Chr 14BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 32.27 % 6.26 12.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48558 461
FHH-Chr 9BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 7 0.16 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41944 401
SS-Chr XBN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41948 401
FHH-Chr 7BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 10 0.1 mg/dl 0.01 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41950 401
FHH-Chr 6BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 16 0.83 g 0.08 0.31 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45393 461
SS-Chr 16BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 6 14.93 ml/min/kg 1.09 2.68 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 57569 526
SS/JrHsdMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 15.03 ml/min/kg 1.18 3.53 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 57572 526
LEW/Crl lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.28 g/kg 0.04 0.13 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57574 526
LE/BluGill lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 14 1.15 g/kg 0.04 0.14 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57578 526
LE/BluGill lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 15 0.97 g/kg 0.04 0.16 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57582 526
FHH-Chr 8BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 19.34 ml/min/kg 0.65 2.04 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57599 526
SS-Chr 18BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 13 9.59 ml/min/kg 0.78 2.81 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57612 526
SS-Chr 18BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 16 12.74 ml/min/kg 1.11 4.46 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57615 526
SS-Chr 9BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 11 9.08 ml/min/kg 1.21 4.0 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57632 526
SS-Chr 14BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 18 15.01 ml/min/kg 0.42 1.79 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57634 526
FHH-Chr 14BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 15.97 ml/min/kg 0.99 2.96 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57639 526
SS-Chr 7BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 14.5 ml/min/kg 1.0 3.46 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57643 526
SS-Chr 17BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 15.19 ml/min/kg 1.73 5.18 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57645 526
FHH/EurMcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 11 10.38 ml/min/kg 0.62 2.07 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57650 526
FHH-Chr 19BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 16.78 ml/min/kg 0.57 1.8 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57651 526
FHH-Chr 9BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 106.98 mmHg 9.1 28.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48704 461
Crl:CD(SD) heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 9 417.18 beats/min 29.61 88.83 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16126 381
LEW/Crl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 16 349.17 beats/min 11.05 44.2 vascular fluid filled catheter 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16128 381
SS-Chr 3BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 14.94 ml/min/kg 1.39 4.8 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57659 526
SS-Chr 11BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 14.0 ml/min/kg 0.41 1.7 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57663 526
Crl:CD(SD) calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.13 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57685 526
WKY/NCrl calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.19 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57688 526
FHH/EurMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 6 0.03 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Dyets 57756 526
SS-Chr 16BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 6 0.06 mmHg-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Dyets 57757 526
LEW/Crl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 8 9.07 mg/kg 1.3 3.68 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57769 526
SS/JrHsdMcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 57.11 % 1.77 5.02 microhematocrit tube assay with visual assessment 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 57776 526
Hsd:SD fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 6 0.07 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 57781 526
FHH-Chr 6BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 20.51 ml/min/kg 1.66 4.69 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57789 526
SHR/NCrl methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 20 13.31 ml/min/kg 0.75 3.33 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57794 526
SS-Chr 5BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 27.52 ml/min/kg 1.56 4.67 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57795 526
FHH-Chr YBN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 21.13 ml/min/kg 1.45 4.36 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57813 526
SS-Chr 18BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 13 12.78 ml/min/kg 1.11 4.01 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57814 526
FHH-Chr 1BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 13 20.4 ml/min/kg 2.16 7.8 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57815 526
FHH-Chr 4BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 28.09 ml/min/kg 0.7 1.86 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57816 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 23.93 ml/min/kg 1.77 5.3 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57819 526
SS-Chr 2BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 12.22 ml/min/kg 1.35 4.26 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57823 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 11 16.01 ml/min/kg 1.65 5.48 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57824 526
SS-Chr 12BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 24.57 ml/min/kg 2.22 6.65 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57825 526
FHH-Chr 1BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 15.45 ml/min/kg 0.91 2.87 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57826 526
FHH-Chr 5BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 30.17 ml/min/kg 5.46 16.37 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57830 526
SS-Chr 9BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 13 15.44 ml/min/kg 1.68 6.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57837 526
FHH-Chr 15BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 23.66 ml/min/kg 1.75 5.24 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57839 526
FHH-Chr 19BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 18.64 ml/min/kg 1.17 3.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57655 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 62.11 % 10.41 38.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48742 461
FHH-Chr 10BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 86.78 % 10.27 20.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48749 461
SS-Chr 5BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 85.95 % 4.33 12.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48754 461
FHH-Chr 8BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 72.94 % 4.89 10.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48757 461
SS-Chr 15BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 89.88 % 6.59 20.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48759 461
FHH-Chr 5BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 65.08 % 4.33 9.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48791 461
FHH-Chr 15BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 69.86 % 3.8 8.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48795 461
SS-Chr 3BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 96.28 % 4.53 13.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48816 461
SS-Chr 11BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 82.25 % 2.64 11.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48820 461
SS-Chr XBN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 92.56 % 7.51 22.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48824 461
FHH-Chr 7BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 81.14 % 3.08 9.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48832 461
FHH-Chr 13BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 25.71 ml/min/kg 1.56 4.94 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57859 526
SS-Chr 3BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 25.32 ml/min/kg 2.58 8.95 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57861 526
SS-Chr YBN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 19 12.64 ml/min/kg 0.53 2.29 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57866 526
SS/JrHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 98 14.63 ml/min/kg 0.58 5.75 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57867 526
SS-Chr 4BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 18 26.28 ml/min/kg 1.81 7.68 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57875 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 22.47 ml/min/kg 1.67 4.72 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57985 526
FHH-Chr 6BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 47.66 ml/min/kg 4.83 14.49 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57988 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 29.04 ml/min/kg 2.45 7.35 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57989 526
FHH-Chr 19BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 14 37.26 degrees C 0.2 0.76 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16630 381
SS-Chr 11BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 36.99 degrees C 0.32 0.96 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16638 381
BN/NHsdMcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 18 35.56 degrees C 0.25 1.05 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16652 381
FHH-Chr 9BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.28 degrees C 0.11 0.32 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16654 381
LE/BluGill absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 0.04 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16670 381
LEW/Crl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 10 0.06 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16671 381
FHH-Chr 12BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 11 36.43 degrees C 0.21 0.68 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16563 381
SS-Chr 5BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.06 degrees C 0.41 1.3 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16567 381
FHH-Chr XBN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.54 degrees C 0.26 0.83 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16568 381
FHH-Chr 8BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 36.9 degrees C 0.18 0.59 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16573 381
SS-Chr 18BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 16 37.23 degrees C 0.12 0.47 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16586 381
FHH-Chr 4BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 12 36.67 degrees C 0.14 0.48 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16590 381
SS-Chr 6BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 17 37.64 degrees C 0.12 0.51 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16606 381
SS-Chr 14BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 37.03 degrees C 0.36 1.24 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16609 381
SS-Chr 17BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 12 37.17 degrees C 0.22 0.76 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16615 381
SS-Chr 17BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.88 degrees C 0.34 1.09 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16620 381
FHH-Chr 17BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.67 degrees C 0.3 0.95 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16621 381
LEW/Crl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 13 25.22 mmHg 0.67 2.43 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16364 381
LE/BluGill partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 27.75 mmHg 1.14 2.79 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16372 381
FHH/EurMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 30.04 mmHg 0.46 1.3 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16453 381
SS/JrHsdMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 26.67 mmHg 1.24 3.52 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 16456 381
FHH-Chr 10BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 42.21 ml/min/kg 5.15 13.64 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57992 526
FHH-Chr 8BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 58.57 ml/min/kg 4.45 14.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58004 526
FHH-Chr YBN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 55.13 ml/min/kg 3.91 11.72 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58012 526
SS-Chr 19BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 64.07 ml/min/kg 6.59 19.77 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58021 526
SS-Chr 2BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 16 37.8 ml/min/kg 2.34 9.36 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58026 526
SS-Chr 6BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 27.7 ml/min/kg 5.6 15.83 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58037 526
SS-Chr 17BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 61.39 ml/min/kg 4.73 14.19 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58041 526
FHH-Chr 17BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 53.94 ml/min/kg 4.37 13.8 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58047 526
BN/NHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 24 0.42 null 0.03 0.15 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58192 526
Hsd:SD lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 8 1.02 g/kg 0.03 0.09 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58196 526
SS-Chr 20BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 5 11.23 ml/min/kg 0.73 1.62 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58429 526
SS/JrHsdMcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 18.17 ml/min/kg 2.18 6.17 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58431 526
Hsd:SD methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 5 0.95 null 0.07 0.16 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58438 526
SS-Chr 20BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 5 8.99 ml/min/kg 0.71 1.58 isolated perfused lung vascular effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58465 526
SS-Chr YBN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 19 34.36 ml/min/kg 2.19 9.52 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58065 526
SS-Chr 1BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 68.62 ml/min/kg 2.48 7.86 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58069 526
FHH-Chr 7BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 44.4 ml/min/kg 3.69 11.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58076 526
Crl:CD(SD) fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.05 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58084 526
Hsd:SD fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 7 0.13 mmHg-1 0.02 0.05 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58094 526
SS/JrHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 7 0.04 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58097 526
SS.BN-(D12Arb13-D12Rat79)/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.44 null 0.03 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58103 526
FHH-Chr 2BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.43 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58105 526
FHH-Chr 20BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 0.43 null 0.03 0.1 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58119 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.47 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58132 526
SS-Chr 19BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.45 null 0.04 0.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58135 526
GH/OmrMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.27 null 0.02 0.04 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58157 526
SS-Chr 17BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.41 null 0.04 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58160 526
FHH/EurMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 11 0.43 null 0.05 0.18 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58165 526
SS-Chr 11BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 16 0.43 null 0.03 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58175 526
SS-Chr 11BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 0.47 null 0.04 0.17 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58178 526
SS/JrHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 7 0.3 null 0.02 0.04 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58185 526
BN/NHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 24 0.46 null 0.02 0.12 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58191 526
FHH-Chr 12BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 12 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58474 526
SS-Chr 5BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58484 526
FHH-Chr XBN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 6 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58489 526
SS-Chr 18BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 24 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58506 526
SS-Chr 12BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58510 526
SS.BN-(D8Rat163-D8Rat81)/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58513 526
FHH-Chr 17BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58535 526
SS-Chr 17BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58536 526
FHH-Chr 11BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.04 mmHg-1 0.01 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58562 526
BN/NHsdMcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 29 0.03 mmHg-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58568 526
LEW/Crl methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.47 null 0.03 0.08 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58573 526
Crl:CD(SD) methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.26 null 0.02 0.05 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58574 526
LE/BluGill methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 13 0.45 null 0.02 0.05 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58577 526
LE/BluGill methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 14 0.42 null 0.01 0.05 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58581 526
LEW/Crl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 9 63.73 % 1.34 4.03 microhematocrit tube assay with visual assessment 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58588 526
SS/JrHsdMcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 7 1.26 mg/kg 0.45 1.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 58604 526
SS-Chr 20BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 8 1.41 g/kg 0.03 0.08 digital scale post excision weight measurement 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58701 526
Hsd:SD methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 6 14.43 ml/min/kg 0.99 2.42 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 58707 526
Hsd:SD calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.11 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58711 526
SS/JrHsdMcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 0.2 mmHg x min x kg x ml-1 0.02 0.05 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 58714 526
FHH-Chr 6BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.45 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58722 526
FHH-Chr XBN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.44 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58729 526
SS-Chr 20BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 32 0.32 null 0.01 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58735 526
SS-Chr 15BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.44 null 0.04 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58736 526
FHH-Chr 8BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.38 null 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58738 526
FHH-Chr 18BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.38 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58741 526
SS-Chr 20BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 39 0.34 null 0.01 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58744 526
FHH-Chr YBN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 14 0.54 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58746 526
FHH-Chr 4BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.53 null 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58749 526
FHH-Chr 5BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.46 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58768 526
SS-Chr 6BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 9 0.33 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58771 526
SS-Chr 10BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.38 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58773 526
FHH-Chr 17BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.54 null 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58779 526
SS-Chr 17BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.37 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58780 526
FHH-Chr 3BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 9 0.6 null 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58787 526
SS-Chr 11BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 20 0.35 null 0.03 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58795 526
SS-Chr 1BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 12 0.46 null 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58801 526
FHH-Chr 7BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.4 null 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58810 526
SS-Chr 16BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 6 205.0 g 4.3 10.5 whole body digital scale 0 Moms and pups used in studies were fed Dyets 58820 526
F344/DuCrl methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 20.03 ml/min/kg 1.59 6.54 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58837 526
SS-Chr 5BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 7 1.06 mg/kg 0.12 0.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58904 526
FHH-Chr XBN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 5 1.8 mg/kg 0.65 1.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58906 526
FHH-Chr 8BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 9 2.28 mg/kg 0.55 1.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58907 526
WKY/NCrl methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 8.73 ml/min/kg 0.78 2.34 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59860 526
F344/DuCrl methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 12.32 ml/min/kg 0.86 3.54 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59863 526
SS-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 11 1.55 mg/kg 0.26 0.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58956 526
SS-Chr 16BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 14 1.26 mg/kg 0.18 0.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58961 526
SS-Chr 1BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.92 mg/kg 0.5 1.59 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58974 526
Crl:CD(SD) heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.37 null 0.03 0.11 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59970 526
WKY/NCrl heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.39 null 0.03 0.09 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59973 526
FHH/EurMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 3 1.09 null 0.12 0.2 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 60090 526
SS/JrHsdMcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 2.26 null 0.35 1.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Dyets 60091 526
LEW/Crl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 226.4 g 5.2 16.3 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60102 526
WKY/NCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 175.3 g 4.5 14.3 whole body digital scale 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60103 526
LEW/Crl FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 8 34.67 ml/min/kg 1.33 3.76 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60129 526
LE/BluGill FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 14 33.59 ml/min/kg 2.58 9.66 isolated perfused lung vascular effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60137 526
GH/OmrMcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 51.33 ml/min 4.17 11.8 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17470 381
Crl:CD(SD) tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 13 0.35 ml 0.03 0.11 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16034 381
SS-Chr 9BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 6.3 g/kg 0.17 0.55 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45604 461
FHH-Chr 2BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 7.61 g/kg 0.35 1.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45610 461
SS-Chr 17BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 9 5.93 g/kg 0.39 1.17 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45617 461
SS-Chr 15BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 5.16 g/kg 0.17 0.53 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45633 461
FHH-Chr 13BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 6.56 g/kg 0.24 0.75 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45642 461
SS-Chr 11BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 23 6.17 g/kg 0.21 0.98 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45648 461
SS-Chr 13BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 19 5.34 g/kg 0.16 0.71 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45650 461
SS/JrHsdMcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 85 5.54 g/kg 0.09 0.86 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45656 461
BN/NHsdMcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 23 5.16 g/kg 0.18 0.85 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45679 461
SS-Chr 2BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 6.15 g/kg 0.12 0.38 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45683 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 33.33 mmHg 4.95 14.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45685 461
SS/JrHsdMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 43.14 mmHg 8.81 24.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45691 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 9.03 IU/g 1.64 3.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45700 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 8.72 IU/g 0.86 2.72 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45704 461
SS-Chr 9BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 15 7.21 IU/g 1.45 5.62 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45706 461
BN/NHsdMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 11.48 IU/g 0.82 2.59 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45710 461
SHR/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 140.97 mmHg 6.4 19.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45723 461
SS-Chr 20BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 22 133.79 mmHg 3.41 16.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45740 461
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 129.71 mmHg 6.81 21.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45746 461
FHH-Chr 4BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 106.05 mmHg 8.34 25.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45747 461
SS-Chr 19BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 101.84 mmHg 5.89 18.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45751 461
SS-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 159.65 mmHg 8.57 25.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45752 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 123.19 mmHg 5.22 16.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45753 461
FHH-Chr 1BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 152.1 mmHg 6.15 19.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45755 461
FHH-Chr 14BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 87.13 mmHg 12.99 25.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45760 461
SS-Chr 17BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 99.09 mmHg 5.04 15.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45771 461
SS-Chr 3BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 88.16 mmHg 5.92 18.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45789 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 42 122.34 mmHg 2.99 19.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45791 461
SS-Chr XBN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 109.65 mmHg 8.86 28.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45797 461
SS-Chr 4BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 12 94.75 mmHg 4.19 14.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45799 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 7 8.16 ml/min/g 0.54 1.42 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 46636 461
FHH-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 9.42 ml/min/g 0.6 1.89 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46640 461
FHH-Chr XBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 9.91 ml/min/g 0.77 2.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46649 461
SS-Chr 15BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 10.01 ml/min/g 0.47 1.41 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46657 461
SS-Chr 10BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 11.84 ml/min/g 0.5 1.51 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46682 461
FHH-Chr 14BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 12.66 ml/min/g 1.06 2.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46694 461
FHH-Chr 17BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 17 10.3 ml/min/g 0.29 1.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46699 461
FHH-Chr 17BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 19 10.42 ml/min/g 0.33 1.45 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46701 461
FHH-Chr 16BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 20 11.54 ml/min/g 0.5 2.26 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46703 461
WKY/NCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 63.79 % 5.5 17.4 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47890 461
WKY/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 5.52 mmHg 0.06 0.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48006 461
Crl:CD(SD) left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 5.3 mmHg 0.12 0.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48010 461
LE/BluGill left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 11 66.25 mmHg 6.85 22.72 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45907 461
Crl:CD(SD) left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 59.39 mmHg 4.85 14.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45935 461
WKY/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 33.16 mmHg 4.85 15.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45939 461
FHH-Chr 12BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 5 20.8 IU/g 5.77 12.9 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45949 461
FHH-Chr 14BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 4 15.19 IU/g 1.83 3.66 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45952 461
FHH-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 13.79 IU/g 1.7 4.8 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45954 461
FHH-Chr 8BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 22.82 IU/g 3.46 10.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45974 461
FHH-Chr 20BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 18.88 IU/g 1.15 3.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45987 461
SS-Chr 15BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 4.45 ml/min/g 0.36 1.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44721 461
FHH-Chr 20BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 5.28 ml/min/g 0.84 2.51 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44724 461
FHH-Chr 4BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 4.11 ml/min/g 0.41 1.16 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44734 461
SS-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 7.37 ml/min/g 0.83 2.61 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44741 461
FHH-Chr 5BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 4.63 ml/min/g 0.68 1.92 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44753 461
FHH-Chr 15BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 4.99 ml/min/g 1.16 2.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44757 461
SS-Chr 17BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 6.08 ml/min/g 0.45 1.34 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44765 461
FHH-Chr 9BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 117.46 mmHg 10.58 31.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45804 461
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 170.38 mmHg 9.07 25.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45864 461
FHH-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 9.92 ml/min/g 0.65 1.95 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46726 461
FHH-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 11.56 ml/min/g 0.59 1.86 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46734 461
Hsd:SD left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 2 117.08 mmHg 11.54 16.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47673 461
FHH-Chr 19BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 5.41 ml/min/g 0.26 0.83 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44770 461
SS-Chr 3BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 4.3 ml/min/g 0.16 0.5 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44778 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 96 5.62 ml/min/g 0.31 3.06 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44784 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 61.29 mmHg 5.44 14.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45059 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 7.69 ml/min/g 2.42 7.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45093 461
FHH-Chr 5BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 43.09 % 4.94 15.64 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47107 461
SS-Chr 6BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 41.11 % 1.74 5.23 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47110 461
SS-Chr 9BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 42.65 % 4.0 16.99 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47114 461
SS-Chr 17BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 56.91 % 4.61 13.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47119 461
FHH-Chr 16BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 20 post-ischemic value/pre-ischemic value x 100% 57.21 % 4.36 19.51 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47127 461
FHH/EurMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 15 post-ischemic value/pre-ischemic value x 100% 29.06 % 3.05 11.8 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47128 461
SS-Chr 3BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 48.99 % 3.5 11.07 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47137 461
FHH-Chr 9BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 44.29 % 4.91 14.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47157 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 4 post-ischemic value/pre-ischemic value x 100% 11.82 % 11.82 23.65 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47170 461
FHH-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 5.91 mmHg 0.14 0.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47182 461
FHH-Chr XBN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 5.31 mmHg 0.27 0.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47197 461
FHH-Chr 20BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.44 mmHg 0.25 0.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47203 461
FHH-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 5.32 mmHg 0.23 0.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47207 461
SS-Chr 18BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.79 mmHg 0.11 0.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47211 461
SS-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.12 mmHg 0.29 0.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47222 461
FHH-Chr 14BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 4 4.82 mmHg 0.35 0.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47228 461
LE/BluGill time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 11 1356.45 s 56.24 186.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45107 461
FHH-Chr 10BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 180.28 beats/min 12.05 34.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45147 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 204.61 beats/min 5.58 17.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45167 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 216.61 beats/min 8.02 24.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45172 461
SS-Chr 18BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 6 5.29 ml/min/g 0.49 1.2 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 44898 461
FHH/EurMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 3.68 ml/min/g 0.63 1.4 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 44900 461
SS-Chr XBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 11 28.39 IU/g 2.19 7.26 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46013 461
FHH-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 13.26 IU/g 2.44 7.71 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46014 461
GH/OmrMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 69.1 % 5.05 13.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46034 461
GH/OmrMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 75.14 % 3.84 11.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46038 461
FHH-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 56.31 mmHg 6.03 15.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46409 461
SHR/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 57.84 mmHg 3.28 10.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46411 461
FHH-Chr 9BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 4.82 mmHg 0.41 1.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47277 461
F344/DuCrl time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 790.5 s 49.86 157.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48128 461
FHH/EurMcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 23.52 % 4.91 13.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 48135 461
FHH-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 0.43 IU/g 0.07 0.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47434 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.4 IU/g 0.1 0.32 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47448 461
SHR/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 17 0.31 IU/g 0.05 0.2 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47452 461
SS-Chr 5BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.41 IU/g 0.1 0.28 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47453 461
SS-Chr 20BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 23 0.32 IU/g 0.04 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47457 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 15 0.12 IU/g 0.04 0.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47459 461
FHH-Chr XBN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 69.7 % 6.84 18.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48291 461
WKY/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 9 8.38 ml/min/g 0.69 2.08 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46174 461
FHH-Chr 6BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 49.05 % 4.74 14.98 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47065 461
FHH-Chr 10BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 80.61 % 3.52 9.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48294 461
SS-Chr 20BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 23 post-ischemic value/pre-ischemic value x 100% 67.11 % 6.89 33.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48297 461
FHH-Chr 20BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 112.41 % 29.28 87.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48301 461
SS-Chr 13BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 17 post-ischemic value/pre-ischemic value x 100% 89.31 % 3.62 14.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48302 461
FHH-Chr 18BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 102.42 % 24.44 73.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48303 461
SS-Chr 18BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 14 post-ischemic value/pre-ischemic value x 100% 84.94 % 4.76 17.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48312 461
FHH-Chr 15BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 87.45 % 7.1 17.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48334 461
FHH-Chr 16BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 20 post-ischemic value/pre-ischemic value x 100% 90.46 % 8.45 37.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48345 461
FHH/EurMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 45 post-ischemic value/pre-ischemic value x 100% 92.48 % 7.69 51.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48357 461
SS/JrHsdMcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 93 post-ischemic value/pre-ischemic value x 100% 80.21 % 2.88 27.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48361 461
SS-Chr XBN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 87.1 % 2.75 8.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48363 461
F344/DuCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.38 IU/g 0.05 0.16 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48380 461
GH/OmrMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 96.8 mmHg 18.68 59.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45314 461
FHH-Chr 16BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 20 44.07 mmHg 4.43 19.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45320 461
FHH-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 35.94 mmHg 6.71 16.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45333 461
SS-Chr 16BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 142.94 mmHg 3.62 11.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45376 461
FHH-Chr 15BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 6 159.17 beats/min 15.56 38.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45187 461
SS-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 344.37 beats/min 74.76 247.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45193 461
SS-Chr XBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 217.37 beats/min 7.26 21.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45216 461
FHH-Chr 8BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 43.78 mmHg 7.2 21.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45275 461
SS-Chr 18BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 12 39.34 mmHg 5.65 19.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45287 461
SS-Chr 6BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 65.27 mmHg 3.75 11.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45303 461
SS-Chr 6BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 49.09 mmHg 7.81 22.1 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45308 461
SS-Chr 17BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 34.83 mmHg 4.68 14.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45312 461
GK mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 5 undefined 118.0 mmHg 7.0 15.65 vascular transducer tipped catheter 0.0 0 103025 2784
GK blood glucose level controlled air oxygen content (21 %) (for 28 days) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. blood glucose amount male 16 days 5 196.2 mg/dl 18.0 40.25 blood glucose analysis 0.0 0 103005 2784
GK heart left ventricle weight to body weight ratio controlled air oxygen content (5 %) (for 28 days) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart left ventricle mass male 16 days 7 2.15 mg/g 0.16 0.42 post excision weight measurement 0.0 0 103010 2784
GK heart right ventricle weight to body weight ratio controlled air oxygen content (5 %) (for 28 days) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart right ventricle mass male 16 days 7 0.48 mg/g 0.04 0.11 post excision weight measurement 0.0 0 103014 2784
Crlj:WI mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 128.0 mmHg 9.0 23.81 vascular transducer tipped catheter 0.0 0 103016 2784
GK mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 5 undefined 137.0 mmHg 6.0 13.42 vascular transducer tipped catheter 0.0 0 103017 2784
GK mean arterial blood pressure controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 7 undefined 111.0 mmHg 5.0 13.23 vascular transducer tipped catheter 0.0 0 103022 2784
GK mean arterial blood pressure controlled air oxygen content (21 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) then NG-nitroarginine methyl ester (50 mg/kg) (for 0.5 hours) and meclofenamate (3 mg/kg) (for 0.5 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. arterial blood pressure trait male 16 days 5 undefined 151.0 mmHg 1.0 2.24 vascular transducer tipped catheter 0.0 0 103029 2784
Crlj:WI heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 380.0 beats/min 18.0 47.62 vascular transducer tipped catheter 0.0 0 103040 2784
Crlj:WI heart rate controlled air oxygen content (5 %) (for 28 days) then vehicle control condition (0.15 ml) (for 0.1 hours) then acetylcholine (5 ug/kg/min) (for 0.1 hours) then sodium nitroprusside (5 ug/kg/min) (for 0.1 hours) Chen YC, et al., Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39. doi: 10.1152/ajpregu.00112.2016. Epub 2016 Jun 1. heart pumping trait male 16 days 7 379.0 beats/min 9.0 23.81 vascular transducer tipped catheter 0.0 0 103042 2784
SS-Chr 1BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 39.91 ml/min 4.36 13.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20279 381
FHH-Chr 11BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 45.06 ml/min 5.78 16.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20282 381
Hsd:SD body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 16 37.05 degrees C 0.19 0.76 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20293 381
FHH-Chr 3BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.15 degrees C 0.04 0.14 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20364 381
FHH-Chr 19BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 14 0.12 degrees C 0.21 0.8 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20367 381
Crl:CD(SD) body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 37.38 degrees C 0.15 0.49 digital rectal thermometry 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19994 381
SS/JrHsdMcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 42.4 ml/min 1.97 7.64 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 20121 381
FHH/EurMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 9 50.99 mmHg 1.52 4.55 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19550 381
SS-Chr 18BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 53.41 mmHg 0.74 1.95 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 19553 381
SS-Chr XBN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 3 0.05 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19811 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 7 0.05 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19825 381
SS-Chr 2BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19830 381
LEW/Crl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 18 121.08 breaths/min 4.35 18.44 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18207 381
LE/BluGill respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 154.11 breaths/min 4.94 17.8 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18215 381
LEW/Crl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 1 116.37 breaths/min stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18298 381
FHH-Chr 12BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 32.71 ml/min 2.41 7.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20199 381
SS-Chr 15BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 33.16 ml/min 3.54 11.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20212 381
FHH-Chr YBN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 21 33.72 ml/min 1.57 7.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20221 381
SS-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 33.55 ml/min 3.83 13.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20231 381
FHH-Chr 5BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 37.76 ml/min 3.5 11.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20238 381
LEW/Crl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 1 34.9 ml/min stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20241 381
SS-Chr 3BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 37.93 ml/min 3.4 11.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20265 381
FHH-Chr 13BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 24.11 ml/min 2.86 9.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20268 381
SS-Chr 13BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 8 54.83 mmHg 1.79 5.06 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20497 381
FHH-Chr 18BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 126.26 % 11.14 31.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53762 381
SS-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 12 123.34 % 8.05 27.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53778 381
FHH-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 100.7 % 8.57 27.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53875 381
FHH/EurMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 49 109.53 % 2.79 19.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53886 381
FHH-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 8 112.63 % 5.52 15.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53894 381
SS-Chr 20BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 112.97 % 3.01 11.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53899 381
SS-Chr 18BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 117.32 % 4.27 18.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53905 381
FHH-Chr 16BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 14 104.47 % 8.95 33.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53929 381
FHH-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 110.72 % 7.4 23.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53948 381
SS/JrHsdMcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 116.02 % 3.05 10.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53951 381
SS-Chr 4BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 127.12 % 4.46 14.79 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53957 381
LEW/Crl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 9.01 % 2.15 6.81 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49029 461
WKY/NCrl heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 7.64 g/kg 0.25 0.77 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49150 461
Hsd:SD heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 11 48.89 mmHg 4.88 16.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 49161 461
GH/OmrMcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 127.38 % 5.98 15.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53745 381
Hsd:SD absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 7 -51.59 mmHg 1.82 4.8 automated blood gas analysis using a Bayer analyzer 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 20407 381
SS-Chr 17BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 55.07 mmHg 2.9 5.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20461 381
SHR/NCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 50.35 mmHg 1.64 4.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20467 381
GH/OmrMcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 48.77 mmHg 2.36 4.08 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20470 381
FHH-Chr 19BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 54.28 mmHg 1.78 4.37 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20483 381
SHR/NCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 146.51 breaths/min 8.7 26.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 17686 381
SS-Chr 11BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.27 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15296 381
SS/JrHsdMcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 74 0.42 ml 0.01 0.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15301 381
SHR/NCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 -0.52 degrees C 0.3 0.95 digital rectal thermometry 0 Moms and pups used in studies were fed Dyets 19583 381
FHH-Chr 16BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 4 -8.39 mmHg 1.37 2.75 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19621 381
FHH-Chr 19BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 -6.32 mmHg 0.72 1.76 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19640 381
FHH-Chr 13BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 -7.93 mmHg 1.81 4.44 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19642 381
FHH-Chr 20BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 3 -2.03 mmHg 3.08 5.33 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19645 381
FHH-Chr 18BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 8 -5.49 mmHg 1.22 3.45 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19648 381
SS-Chr 11BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 -6.27 mmHg 0.87 2.13 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19656 381
FHH-Chr 9BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.2 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15315 381
SS-Chr 7BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 105.42 % 3.66 10.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54031 381
SS-Chr 3BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 110.05 % 5.59 19.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54042 381
SS-Chr 1BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 105.0 % 4.88 15.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54056 381
SS-Chr 4BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 121.12 % 6.64 22.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54058 381
SS/JrHsdMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 14 121.97 breaths/min 3.38 12.66 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 15371 381
WKY/NCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 7.55 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18089 381
SS-Chr 9BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 139.29 % 6.62 20.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13715 381
SS-Chr 7BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 163.58 % 12.69 40.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13731 381
FHH-Chr 19BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 14 %change=VE during 2-3 min hypoxia/control during standard conditions 129.68 % 8.17 30.57 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13734 381
SS-Chr YBN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 19 %change=VE during 2-3 min hypoxia/control during standard conditions 145.58 % 4.29 18.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13747 381
FHH-Chr 9BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 120.3 % 4.37 13.81 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13757 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 9 145.0 U/l 6.68 20.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36398 401
SS-Chr 19BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 10 99.9 U/l 4.03 12.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36401 401
F344/DuCrl serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 17 66.59 mg/dl 4.34 17.91 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36465 401
FHH-Chr 13BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 10 29.04 mmHg 1.19 3.75 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17254 381
SS-Chr XBN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 4 27.93 mmHg 1.11 2.22 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17267 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 %change=VE during 2-3 min hypoxia/control during standard conditions 137.06 % 8.57 29.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13670 381
SS-Chr 11BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 45.13 ml/min 3.15 9.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18728 381
SS-Chr 1BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 52.32 ml/min 4.74 14.98 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18733 381
SS-Chr 17BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 2 7.48 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17039 381
FHH-Chr 17BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.46 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17042 381
FHH-Chr 19BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 9 7.48 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17050 381
SS-Chr 15BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.45 null 0.05 0.12 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17053 381
SS-Chr 15BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 2 7.5 null 0.07 0.1 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17055 381
FHH-Chr 7BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 8 122.57 breaths/min 8.44 23.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18348 381
SS-Chr 16BN/Mcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 6 %change=VE during7-9 min hypoxia/control during standard conditions 141.74 % 11.86 29.05 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18370 381
FHH/EurMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 %change=VE during7-9 min hypoxia/control during standard conditions 154.66 % 8.19 28.38 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18373 381
GH/OmrMcwi percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 7 %change=VE during7-9 min hypoxia/control during standard conditions 141.15 % 6.17 16.32 stop flow air displacement plethysmography 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18375 381
SS.BN-(D12Arb13-D12Rat79)/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 12 0.41 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13913 381
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 466.65 beats/min 11.1 31.39 vascular fluid filled catheter 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18755 381
GH/OmrMcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 7 -0.34 degrees C 0.18 0.48 digital rectal thermometry 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14137 381
SS-Chr 14BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 124.12 mmHg 2.89 8.66 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14311 381
SS-Chr 15BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 4 145.88 mmHg 5.94 11.89 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14337 381
SS-Chr 11BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 6 125.86 mmHg 4.39 10.74 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14354 381
LE/BluGill minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 46.22 ml/min 2.52 7.97 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18967 381
Hsd:SD hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 4 58.8 % 1.58 3.17 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36284 401
LE/BluGill mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 10 19.15 pg 0.26 0.81 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36363 401
FHH-Chr 20BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.28 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15239 381
FHH-Chr 20BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 8 0.24 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15242 381
FHH-Chr 13BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 %change=VE during 2-3 min hypoxia/control during standard conditions 136.09 % 10.41 34.53 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13741 381
SS-Chr 13BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 158.2 % 14.02 44.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13687 381
FHH-Chr 2BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 4.86 g/dl 0.08 0.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36949 401
FHH-Chr XBN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 4.6 g/dl 0.17 0.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36958 401
SS-Chr 5BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 7 5.41 g/dl 0.04 0.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36960 401
FHH-Chr 8BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 10 5.22 g/dl 0.05 0.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36963 401
SS-Chr 18BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 9 6.17 g/dl 0.09 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36979 401
FHH-Chr 1BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 9 5.46 g/dl 0.09 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36988 401
SS-Chr 16BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 7 0.26 mg/dl 0.04 0.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37068 401
SS/JrHsdMcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 7 0.26 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Dyets 37070 401
SS-Chr 10BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 10 72.4 mg/dl 1.85 5.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37126 401
FHH-Chr XBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 138.12 breaths/min 6.86 21.68 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14794 381
SS-Chr 15BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 114.14 breaths/min 5.97 18.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14798 381
FHH-Chr 20BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 8 149.0 breaths/min 16.24 45.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14803 381
SS-Chr 10BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 11 0.34 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13952 381
SS-Chr 9BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.46 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13958 381
SS-Chr 14BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.37 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13960 381
SS-Chr 17BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 12 0.41 ml 0.03 0.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13966 381
SS-Chr 3BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 11 0.29 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13985 381
SS-Chr 4BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 15 0.33 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13999 381
WKY/NCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 20 0.28 ml 0.01 0.06 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14015 381
SS-Chr 20BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 27 9.35 mg/dl 0.06 0.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36626 401
FHH-Chr 8BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 10 9.64 mg/dl 0.13 0.42 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36629 401
SS-Chr 13BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 12 9.39 mg/dl 0.13 0.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36631 401
FHH-Chr 18BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 10 9.43 mg/dl 0.05 0.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36634 401
SS-Chr 17BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.49 mg/dl 0.09 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36666 401
FHH-Chr 16BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 9 9.6 mg/dl 0.16 0.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36667 401
SS-Chr 11BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 17 9.27 mg/dl 0.1 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36686 401
SS-Chr 11BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 15 9.67 mg/dl 0.09 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36689 401
FHH-Chr 9BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 7 9.29 mg/dl 0.27 0.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36700 401
Hsd:SD mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 5 65.28 fl 1.27 2.84 automated blood cell counting method 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36713 401
LEW/Crl serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 10 8.0 mg/dl 0.31 0.99 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36716 401
Hsd:SD serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 4 162.5 U/l 11.27 22.55 standard blood chemistry panel 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 36725 401
SS-Chr 20BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.81 mg/dl 0.28 0.8 standard blood chemistry panel 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 36730 401
SHR/NCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.25 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Dyets 14902 381
F344/DuCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 18 %change=VE during 2-3 min hypoxia/control during standard conditions 137.7 % 6.98 29.6 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19308 381
SS-Chr 15BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 15 41.75 ml/min 3.0 11.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18665 381
FHH-Chr 15BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 45.53 ml/min 3.91 11.72 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18702 381
SS-Chr 13BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 10 380.7 beats/min 11.99 37.92 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17518 381
SS-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 350.62 beats/min 18.91 50.03 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17523 381
SS-Chr YBN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 18 413.66 beats/min 11.85 50.27 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17526 381
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 10 393.79 beats/min 12.81 40.52 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17537 381
FHH-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 3 449.72 beats/min 33.88 58.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17543 381
SS-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 12 451.08 beats/min 16.57 57.41 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17551 381
FHH-Chr 15BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 127.26 breaths/min 9.39 28.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14834 381
GH/OmrMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 7 131.49 breaths/min 4.61 12.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14839 381
SS-Chr 17BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 113.91 breaths/min 6.55 20.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14842 381
SS-Chr 16BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 13 126.24 breaths/min 3.55 12.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14853 381
FHH/EurMcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 49 130.29 breaths/min 3.56 24.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14858 381
SS-Chr XBN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 14 120.77 breaths/min 9.05 33.87 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14875 381
GH/OmrMcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 25.23 mmHg 1.3 3.44 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18168 381
FHH-Chr 16BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 19 5.31 mmHg 0.12 0.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47240 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 6.21 mmHg 0.14 0.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47248 461
FHH-Chr 4BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 2 -37.85 mmHg 2.65 3.75 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19495 381
SS-Chr 19BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 3 -39.93 mmHg 1.85 3.2 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19498 381
FHH-Chr 7BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 3 -46.88 mmHg 6.1 10.56 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19503 381
SS-Chr 9BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 11 0.05 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19763 381
SS-Chr 10BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 4 0.08 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19769 381
SS-Chr 7BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 7 0.05 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19772 381
FHH-Chr 8BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 0.05 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19794 381
SS-Chr 13BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 8 0.07 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19806 381
SS-Chr 16BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 20 post-ischemic value/pre-ischemic value x 100% 61.26 % 4.99 22.3 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47131 461
FHH-Chr 19BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 59.55 % 8.38 26.5 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47133 461
SS/JrHsdMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 56.18 % 3.93 15.71 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47148 461
FHH/EurMcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 43.17 % 6.93 15.49 isolated perfused heart effluent collection 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47171 461
FHH-Chr 10BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 5.74 mmHg 0.22 0.67 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47196 461
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 292.76 beats/min 77.04 203.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45162 461
LE/BluGill heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 1.36 g 0.08 0.25 digital scale post excision weight measurement 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45039 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 13 12.15 ml/min/g 1.17 4.22 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 45052 461
SS-Chr 18BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 236.58 beats/min 11.09 29.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45079 461
Crl:CD(SD) arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 14.61 ml/min/g 0.64 1.91 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45085 461
LE/BluGill arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 13.05 ml/min/g 0.86 2.57 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45087 461
LE/BluGill arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 11.25 ml/min/g 0.8 2.25 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45092 461
GH/OmrMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 5.72 ml/min/g 0.45 1.1 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45096 461
LE/BluGill time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 1330.89 s 55.91 167.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45112 461
FHH-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 155.46 beats/min 14.13 37.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45135 461
FHH-Chr XBN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 138.46 beats/min 14.47 38.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45144 461
Hsd:SD blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 7 7.52 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17454 381
LEW/Crl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 20 0.31 ml 0.01 0.06 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16038 381
FHH-Chr 17BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 17 215.43 beats/min 14.01 57.77 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45194 461
FHH-Chr 12BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 59.57 mmHg 5.75 18.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46408 461
FHH-Chr 13BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 5.26 mmHg 0.26 0.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47256 461
FHH/EurMcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 5.6 mmHg 0.51 1.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 47376 461
FHH-Chr 16BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 20 225.81 beats/min 17.84 79.76 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45198 461
BN/NHsdMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 24 222.91 beats/min 8.17 40.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45225 461
FHH-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 210.62 beats/min 11.76 37.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45229 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 32.2 mmHg 5.63 12.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45244 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 40.6 mmHg 11.99 26.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45246 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 383.18 beats/min 58.34 154.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45252 461
FHH-Chr 12BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 14 50.37 mmHg 5.31 19.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45255 461
SS-Chr 15BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 33.01 mmHg 4.72 14.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45273 461
SS-Chr 13BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 17 52.0 mmHg 7.09 29.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45282 461
FHH-Chr 4BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 27.33 mmHg 3.79 11.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45288 461
SS-Chr 19BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 28.89 mmHg 5.82 14.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45290 461
SS-Chr 19BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 40.09 mmHg 5.31 15.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45292 461
SS-Chr 7BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 47.28 mmHg 7.76 25.75 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45315 461
FHH-Chr 17BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 17 0.26 IU/g 0.06 0.24 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47447 461
SS-Chr 6BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 78.42 % 25.58 80.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48333 461
SS-Chr 10BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 105.5 % 17.6 52.8 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48335 461
FHH-Chr 17BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 93.49 % 15.85 63.4 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48343 461
SS-Chr 16BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 15 post-ischemic value/pre-ischemic value x 100% 90.94 % 12.24 47.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48352 461
SS-Chr YBN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 29 post-ischemic value/pre-ischemic value x 100% 86.66 % 4.99 26.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48360 461
FHH-Chr 9BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 83.83 % 4.67 14.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48375 461
SS-Chr 13BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 14 134.84 mmHg 6.73 25.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45741 461
SS-Chr 18BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 130.62 mmHg 6.87 18.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45743 461
FHH-Chr 19BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 105.58 mmHg 3.21 9.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45781 461
SS-Chr 16BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 17 120.62 mmHg 4.51 18.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45783 461
SS-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 116.72 mmHg 6.69 25.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45790 461
FHH-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 118.38 mmHg 5.0 12.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45802 461
FHH-Chr 3BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 35.57 mmHg 6.48 14.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45323 461
FHH/EurMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 44 38.03 mmHg 2.76 18.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45332 461
FHH-Chr 7BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 41.23 mmHg 6.35 20.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45351 461
GH/OmrMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 6 13.29 IU/g 2.15 5.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45367 461
FHH/EurMcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 6 13.17 IU/g 2.67 6.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Dyets 45369 461
FHH-Chr 10BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 6.18 g/kg 0.33 1.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45624 461
FHH-Chr 3BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 6 7.58 g/kg 1.12 2.75 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45632 461
SS-Chr 13BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 22 5.62 g/kg 0.13 0.63 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45641 461
FHH-Chr 3BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 7.76 g/kg 0.49 1.48 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45651 461
FHH-Chr 11BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 10 7.31 g/kg 0.26 0.83 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45665 461
SS.BN-(D8Rat163-D8Rat81)/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 12 6.27 g/kg 0.24 0.83 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45667 461
SS-Chr XBN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 13 4.97 g/kg 0.18 0.66 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45680 461
FHH-Chr 1BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 6.12 g/kg 0.25 0.78 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45684 461
GH/OmrMcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 100.29 mmHg 15.02 39.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45688 461
SS-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 5 6.93 IU/g 2.76 6.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45693 461
SS-Chr 9BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 16 7.93 IU/g 1.33 5.34 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45701 461
FHH-Chr 6BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 121.41 mmHg 7.97 22.53 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45718 461
FHH-Chr 12BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 9 143.49 mmHg 10.46 31.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45720 461
FHH-Chr 8BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 161.54 mmHg 7.01 15.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45730 461
FHH-Chr 8BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 123.32 mmHg 7.43 16.62 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45734 461
FHH-Chr 6BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 13.97 ml/min/g 1.52 4.81 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46641 461
FHH-Chr 10BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 9.74 ml/min/g 1.07 3.02 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46652 461
FHH-Chr 8BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 13.05 ml/min/g 0.86 2.57 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46654 461
SS-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 21 12.34 ml/min/g 0.35 1.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46660 461
SS-Chr 20BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 25 12.28 ml/min/g 0.72 3.59 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46664 461
FHH-Chr YBN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 11 10.86 ml/min/g 1.0 3.33 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46666 461
FHH-Chr 4BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 10.26 ml/min/g 0.6 1.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46669 461
FHH-Chr 1BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 15.29 ml/min/g 0.72 2.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46679 461
FHH-Chr 15BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 13.47 ml/min/g 1.6 4.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46681 461
SS-Chr 10BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 12.43 ml/min/g 0.82 2.47 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46693 461
SS-Chr 17BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 11.1 ml/min/g 1.11 3.34 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46700 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 23 11.44 ml/min/g 0.77 3.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46714 461
SS/JrHsdMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 97 11.61 ml/min/g 0.23 2.26 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46719 461
SS-Chr 4BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 18 11.25 ml/min/g 0.63 2.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46727 461
GH/OmrMcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 9.98 ml/min/g 2.16 6.83 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44762 461
FHH/EurMcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 158.4 mmHg 7.97 17.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45813 461
SS-Chr 16BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 12 1.22 g 0.04 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Dyets 45828 461
F344/DuCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 43.08 mmHg 7.1 22.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45904 461
FHH-Chr 15BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 16.71 IU/g 2.7 7.63 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45950 461
FHH-Chr 6BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 9.75 IU/g 0.99 2.8 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45957 461
FHH-Chr 19BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 20.36 IU/g 0.84 2.64 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45975 461
FHH-Chr 8BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 22.8 IU/g 1.36 4.31 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45982 461
FHH-Chr 20BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 20.03 IU/g 3.07 9.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45984 461
FHH-Chr 18BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 5 28.17 IU/g 2.11 4.72 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45986 461
FHH-Chr YBN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 17.9 IU/g 2.2 6.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45992 461
FHH-Chr 9BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 14.54 IU/g 2.21 6.64 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46009 461
Hsd:SD arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 7.09 ml/min/g 0.94 2.97 isolated perfused heart effluent collection 0 Moms were fed vendors standard diet, pups were fed Dyets upon arrival at MCW. For rats received from Harlan 46842 461
SS-Chr 16BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 11 559.08 s 58.59 194.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 45836 461
FHH/EurMcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 5 234.91 beats/min 11.76 26.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 45871 461
FHH-Chr 8BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 4.77 ml/min/g 0.46 1.44 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44723 461
SS-Chr 13BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 19 6.62 ml/min/g 0.27 1.18 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44725 461
FHH-Chr 9BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 13.26 IU/g 2.5 7.51 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46015 461
SS-Chr 16BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 69.53 % 3.27 10.84 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Dyets 46033 461