SS-Chr 2BN/Mcwi |
respiration rate |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
13 |
|
101.38 |
breaths/min |
2.9 |
10.46 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14821 |
381 |
SS-Chr 2BN/Mcwi |
blood pH |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
female |
82 days-99 days |
9 |
|
7.53 |
null |
0.01 |
0.04 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
17088 |
381 |
SS-Chr 2BN/Mcwi |
percent change in tidal volume |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
13 |
|
110.22 |
% |
4.16 |
15.01 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54014 |
381 |
SS-Chr 2BN/Mcwi |
mean arterial blood pressure |
control condition |
PhysGen Respiratory data |
arterial blood pressure trait |
male |
82 days-99 days |
8 |
|
124.86 |
mmHg |
3.65 |
10.31 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19911 |
381 |
SS-Chr 2BN/Mcwi |
mean arterial blood pressure |
resting on treadmill (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
male |
82 days-99 days |
12 |
|
125.67 |
mmHg |
3.56 |
12.34 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20067 |
381 |
SS-Chr 2BN/Mcwi |
absolute change in body temperature |
air carbon dioxide content (7 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
12 |
|
-0.08 |
degrees C |
0.18 |
0.62 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15696 |
381 |
SS-Chr 2BN/Mcwi |
plasma renin activity level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
renin activity |
female |
80 days-99 days |
10 |
|
0.99 |
ng/ml/h |
0.13 |
0.43 |
radioimmunoassay |
|
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52477 |
482 |
SS-Chr 2BN/Mcwi |
mean arterial blood pressure |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
arterial blood pressure trait |
male |
80 days-99 days |
9 |
|
174.74 |
mmHg |
5.35 |
16.04 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52877 |
482 |
SS-Chr 2BN/Mcwi |
urine total protein excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
total urine protein amount |
female |
80 days-99 days |
10 |
|
65.93 |
mg/d |
11.1 |
35.11 |
automated urine total protein analysis |
|
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52722 |
482 |
SS-Chr 2BN/Mcwi |
absolute change in heart rate |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
female |
82 days-99 days |
11 |
heart rate during walking-heart rate during rest |
101.42 |
beats/min |
7.49 |
24.86 |
vascular fluid filled catheter |
|
0 |
0 |
|
|
Moms and pups used in studies were fed Teklad |
13408 |
381 |
SS-Chr 2BN/Mcwi |
absolute change in heart rate |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
male |
82 days-99 days |
9 |
heart rate during walking-heart rate during rest |
92.25 |
beats/min |
11.0 |
33.01 |
vascular fluid filled catheter |
|
0 |
0 |
|
|
Moms and pups used in studies were fed Teklad |
13413 |
381 |
SS-Chr 2BN/Mcwi |
body temperature |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
12 |
|
37.67 |
degrees C |
0.16 |
0.55 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17661 |
381 |
SS-Chr 2BN/Mcwi |
heart rate |
resting on treadmill (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
male |
82 days-99 days |
12 |
|
402.23 |
beats/min |
7.1 |
24.61 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17759 |
381 |
SS-Chr 2BN/Mcwi |
blood pH |
control condition |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
male |
82 days-99 days |
11 |
|
7.45 |
null |
0.01 |
0.03 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20669 |
381 |
SS-Chr 2BN/Mcwi |
body temperature |
resting on treadmill (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
12 |
|
37.39 |
degrees C |
0.12 |
0.41 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18140 |
381 |
SS-Chr 2BN/Mcwi |
body temperature |
resting on treadmill (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
12 |
|
37.47 |
degrees C |
0.11 |
0.38 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18145 |
381 |
SS-Chr 2BN/Mcwi |
percent change in ventilation |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
12 |
%change=VE during 2-3 min hypercapnia/control during standard conditions |
275.87 |
% |
12.33 |
42.7 |
stop flow air displacement plethysmography |
|
0 |
0 |
|
|
Moms and pups used in studies were fed Teklad |
19238 |
381 |
SS-Chr 2BN/Mcwi |
heart left ventricle infarction weight to total heart left ventricle weight ratio |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) |
PhysGen Cardiac data |
heart left ventricle integrity trait |
male |
49 days-63 days |
8 |
|
7.03 |
% |
2.54 |
7.19 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49423 |
461 |
SS-Chr 2BN/Mcwi |
time to onset of heart contraction |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
female |
49 days-63 days |
15 |
|
979.67 |
s |
39.77 |
154.03 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
50142 |
461 |
SS-Chr 2BN/Mcwi |
time to onset of heart contraction |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
male |
49 days-63 days |
10 |
|
998.7 |
s |
52.91 |
167.32 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
50146 |
461 |
SS-Chr 2BN/Mcwi |
hematocrit |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
female |
77 days-91 days |
10 |
|
57.17 |
% |
0.47 |
1.49 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39014 |
401 |
SS-Chr 2BN/Mcwi |
hematocrit |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
male |
77 days-91 days |
15 |
|
58.69 |
% |
0.92 |
3.58 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39018 |
401 |
SS-Chr 2BN/Mcwi |
serum bicarbonate level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood bicarbonate amount |
female |
77 days-91 days |
10 |
|
16.0 |
mmol/l |
0.61 |
1.94 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42085 |
401 |
SS-Chr 2BN/Mcwi |
serum aspartate aminotransferase activity level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood aspartate transaminase amount |
male |
77 days-91 days |
6 |
|
72.33 |
U/l |
8.02 |
19.65 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42493 |
401 |
SS-Chr 2BN/Mcwi |
serum aspartate aminotransferase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood aspartate transaminase amount |
male |
77 days-91 days |
15 |
|
79.0 |
U/l |
3.91 |
15.13 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42797 |
401 |
SS-Chr 2BN/Mcwi |
serum sodium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood sodium amount |
female |
77 days-91 days |
10 |
|
146.0 |
mmol/l |
0.45 |
1.41 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39411 |
401 |
SS-Chr 2BN/Mcwi |
percent change in tidal volume |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
13 |
|
172.11 |
% |
6.79 |
24.47 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54450 |
381 |
SS-Chr 2BN/Mcwi |
systolic blood pressure |
control condition |
Viel EC, et al., Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H938-44. Epub 2009 Dec 31. |
arterial blood pressure trait |
male |
84 days
| 12 |
|
150.0 |
mmHg |
3.0 |
10.39 |
tail cuff plethysmography |
|
0.0 |
0 |
|
|
|
67228 |
730 |
SS-Chr 2BN/Mcwi |
serum albumin level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood albumin amount |
male |
77 days-91 days |
6 |
|
3.95 |
g/dl |
0.11 |
0.27 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40483 |
401 |
SS-Chr 2BN/Mcwi |
serum total bilirubin level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood bilirubin amount |
female |
77 days-91 days |
9 |
|
0.1 |
mg/dl |
0.0 |
0.0 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42951 |
401 |
SS-Chr 2BN/Mcwi |
serum globulin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood globulin amount |
female |
77 days-91 days |
10 |
|
2.28 |
g/dl |
0.16 |
0.51 |
standard blood chemistry panel |
|
|
0 |
|
replaced obsolete serum globulin level term, 1/19/2016 |
Moms and pups used in studies were fed Teklad |
40573 |
401 |
SS-Chr 2BN/Mcwi |
serum globulin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood globulin amount |
male |
77 days-91 days |
15 |
|
2.75 |
g/dl |
0.14 |
0.53 |
standard blood chemistry panel |
|
|
0 |
|
replaced obsolete serum globulin level term, 1/19/2016 |
Moms and pups used in studies were fed Teklad |
40577 |
401 |
SS-Chr 2BN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
female |
77 days-91 days |
11 |
|
1.2 |
mg/kg |
0.2 |
0.68 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59232 |
526 |
SS-Chr 2BN/Mcwi |
lung dry weight to body weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
lung mass |
female |
77 days-91 days |
10 |
|
1.46 |
g/kg |
0.03 |
0.09 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59680 |
526 |
SS-Chr 2BN/Mcwi |
lung dry weight to body weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
lung mass |
male |
77 days-91 days |
16 |
|
1.18 |
g/kg |
0.03 |
0.11 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59684 |
526 |
SS-Chr 2BN/Mcwi |
blood lymphocyte count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
lymphocyte quantity |
female |
77 days-91 days |
10 |
|
4.26 |
x 1000 cells/ul |
0.19 |
0.62 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41526 |
401 |
SS-Chr 2BN/Mcwi |
serum total cholesterol level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood cholesterol amount |
female |
77 days-91 days |
9 |
|
89.78 |
mg/dl |
1.93 |
5.78 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38501 |
401 |
SS-Chr 2BN/Mcwi |
plasma anion gap |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
ion homeostasis trait |
male |
77 days-91 days |
13 |
|
31.38 |
mmol/l |
1.51 |
5.45 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38288 |
401 |
SS-Chr 2BN/Mcwi |
red blood cell count |
control condition (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
male |
77 days-91 days |
6 |
|
7.73 |
x 10E6 cells/ul |
0.11 |
0.27 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42045 |
401 |
SS-Chr 2BN/Mcwi |
left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
8 |
|
159.27 |
mmHg |
6.89 |
19.5 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48647 |
461 |
SS-Chr 2BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
|
230.53 |
beats/min |
8.76 |
27.71 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47609 |
461 |
SS-Chr 2BN/Mcwi |
mean corpuscular volume |
control condition (for 14 days) |
PhysGen Biochemistry data |
erythrocyte size trait |
female |
77 days-91 days |
9 |
|
57.83 |
fl |
0.15 |
0.45 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38715 |
401 |
SS-Chr 2BN/Mcwi |
mean corpuscular volume |
control condition (for 14 days) |
PhysGen Biochemistry data |
erythrocyte size trait |
male |
77 days-91 days |
6 |
|
58.57 |
fl |
0.33 |
0.81 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38723 |
401 |
SS-Chr 2BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
15 |
|
58.0 |
% |
5.65 |
21.87 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57283 |
522 |
SS-Chr 2BN/Mcwi |
partial pressure of blood carbon dioxide (Pco2) |
control condition |
PhysGen Respiratory data |
blood carbon dioxide amount |
female |
82 days-99 days |
9 |
|
33.23 |
mmHg |
1.23 |
3.7 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16108 |
381 |
SS-Chr 2BN/Mcwi |
partial pressure of blood carbon dioxide (Pco2) |
control condition |
PhysGen Respiratory data |
blood carbon dioxide amount |
male |
82 days-99 days |
11 |
|
32.3 |
mmHg |
1.32 |
4.38 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16115 |
381 |
SS-Chr 2BN/Mcwi |
FAPGG metabolism-surface area product |
controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
50.41 |
ml/min/kg |
4.22 |
13.34 |
isolated perfused lung vascular effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58022 |
526 |
SS-Chr 2BN/Mcwi |
body weight |
control condition (for 21 days) |
PhysGen Vascular data |
body mass |
female |
70 days-84 days |
20 |
|
175.6 |
g |
3.2 |
14.3 |
whole body digital scale |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55473 |
522 |
SS-Chr 2BN/Mcwi |
tidal volume |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
12 |
|
0.55 |
ml |
0.04 |
0.13 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16500 |
381 |
SS-Chr 2BN/Mcwi |
body temperature |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
12 |
|
37.1 |
degrees C |
0.27 |
0.93 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16595 |
381 |
SS-Chr 2BN/Mcwi |
partial pressure of blood oxygen |
resting on treadmill (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
male |
82 days-99 days |
12 |
|
100.9 |
mmHg |
1.74 |
6.03 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16418 |
381 |
SS-Chr 2BN/Mcwi |
body temperature |
control condition |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
13 |
|
37.34 |
degrees C |
0.12 |
0.45 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16839 |
381 |
SS-Chr 2BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
16 |
|
-7.24 |
null |
0.04 |
0.15 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56162 |
522 |
SS-Chr 2BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
14 |
|
63.07 |
% |
5.21 |
19.51 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54837 |
522 |
SS-Chr 2BN/Mcwi |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
12 |
|
-8.47 |
null |
0.11 |
0.37 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54634 |
522 |
SS-Chr 2BN/Mcwi |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
|
0.17 |
10E-7mol/l |
0.14 |
0.43 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56255 |
522 |
SS-Chr 2BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
16 |
|
24.63 |
% |
2.27 |
9.09 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55152 |
522 |
SS-Chr 2BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
16 |
|
31.13 |
% |
3.38 |
13.52 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55157 |
522 |
SS-Chr 2BN/Mcwi |
methylene blue to FAPGG metabolism-surface area product ratio |
methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
9 |
|
0.24 |
null |
0.02 |
0.06 |
isolated perfused lung vascular effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59848 |
526 |
SS-Chr 2BN/Mcwi |
calculated pulmonary vascular resistance normalized to body weight |
Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
0.13 |
mmHg x min x kg x ml-1 |
0.02 |
0.05 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59956 |
526 |
SS-Chr 2BN/Mcwi |
arterial blood flow rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
15 |
|
11.72 |
ml/min/g |
0.89 |
3.46 |
isolated perfused heart effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46893 |
461 |
SS-Chr 2BN/Mcwi |
arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
10 |
|
6.52 |
ml/min/g |
0.72 |
2.27 |
isolated perfused heart effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
44745 |
461 |
SS-Chr 2BN/Mcwi |
left ventricular developed pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
|
134.01 |
mmHg |
7.37 |
23.3 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
|
46773 |
461 |
SS-Chr 2BN/Mcwi |
left ventricular developed pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
9 |
|
142.43 |
mmHg |
4.4 |
13.21 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
|
46777 |
461 |
SS-Chr 2BN/Mcwi |
left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
8 |
|
158.91 |
mmHg |
9.27 |
26.22 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45756 |
461 |
SS-Chr 2BN/Mcwi |
left ventricular developed pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
9 |
|
62.35 |
mmHg |
9.05 |
27.15 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47938 |
461 |
SS-Chr 2BN/Mcwi |
left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
|
68.15 |
mmHg |
11.65 |
36.84 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45297 |
461 |
SS-Chr 2BN/Mcwi |
renal afferent arteriole diameter |
controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) |
Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. |
kidney arteriole morphology trait |
not specified |
91 days-133 days |
8 |
|
21.1 |
um |
0.9 |
2.55 |
ex vivo videomicroscopy |
renal afferent arteriole |
120.0 |
0 |
ex vivo videomicroscopy (MMO:0000319) |
renal afferent arteriole diameter (CMO:0003725) |
renal arteriole morphology trait |
106495 |
3030 |
SS-Chr 2BN/Mcwi |
renal afferent arteriole diameter |
controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) |
Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. |
kidney arteriole morphology trait |
not specified |
91 days-133 days |
6 |
|
20.8 |
um |
1.0 |
2.45 |
ex vivo videomicroscopy |
renal afferent arteriole |
120.0 |
0 |
ex vivo videomicroscopy (MMO:0000319) |
renal afferent arteriole diameter (CMO:0003725) |
renal arteriole morphology trait |
106500 |
3030 |
SS-Chr 2BN/Mcwi |
percent change in tidal volume |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
12 |
|
116.59 |
% |
5.53 |
19.17 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
53910 |
381 |
SS-Chr 2BN/Mcwi |
percent change in respiration rate |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
13 |
|
168.93 |
% |
10.58 |
38.13 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54244 |
381 |
SS-Chr 2BN/Mcwi |
serum total cholesterol level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood cholesterol amount |
female |
77 days-91 days |
10 |
|
83.6 |
mg/dl |
3.33 |
10.54 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37120 |
401 |
SS-Chr 2BN/Mcwi |
heart rate |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
female |
82 days-99 days |
11 |
|
519.62 |
beats/min |
6.89 |
22.84 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13811 |
381 |
SS-Chr 2BN/Mcwi |
respiration rate |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
12 |
|
104.14 |
breaths/min |
6.17 |
21.36 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14817 |
381 |
SS-Chr 2BN/Mcwi |
serum calcium level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood calcium amount |
male |
77 days-91 days |
6 |
|
9.22 |
mg/dl |
0.12 |
0.29 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36835 |
401 |
SS-Chr 2BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
10 |
|
174.67 |
beats/min |
14.84 |
46.94 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45171 |
461 |
SS-Chr 2BN/Mcwi |
heart effluent lactate dehydrogenase activity level normalized to heart weight |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart lactate dehydrogenase activity |
male |
49 days-63 days |
9 |
|
0.29 |
IU/g |
0.06 |
0.17 |
isolated perfused heart effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47372 |
461 |
SS-Chr 2BN/Mcwi |
blood monocyte count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
monocyte quantity |
male |
77 days-91 days |
15 |
|
0.5 |
x 1000 cells/ul |
0.06 |
0.24 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39701 |
401 |
SS-Chr 2BN/Mcwi |
plasma creatinine level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood creatinine amount |
male |
77 days-91 days |
6 |
|
0.2 |
mg/dl |
0.03 |
0.06 |
automated plasma creatinine analysis |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42722 |
401 |
SS-Chr 2BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
14 |
|
-7.21 |
null |
0.1 |
0.38 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56972 |
522 |
SS-Chr 2BN/Mcwi |
maximum contractile force per wet weight of aorta |
potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
19 |
|
1.02 |
g/mg |
0.07 |
0.31 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55855 |
522 |
SS-Chr 2BN/Mcwi |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
14 |
|
-8.76 |
null |
0.1 |
0.36 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56038 |
522 |
SS-Chr 2BN/Mcwi |
left ventricular systolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
13 |
|
146.4 |
mmHg |
9.44 |
34.03 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45527 |
461 |
SS-Chr 2BN/Mcwi |
red blood cell count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
female |
77 days-91 days |
10 |
|
9.16 |
x 10E6 cells/ul |
0.11 |
0.33 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39260 |
401 |
SS-Chr 2BN/Mcwi |
serum potassium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood potassium amount |
female |
77 days-91 days |
10 |
|
4.29 |
mmol/l |
0.08 |
0.26 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38089 |
401 |
SS-Chr 2BN/Mcwi |
mean corpuscular hemoglobin |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
10 |
|
19.96 |
pg |
0.15 |
0.48 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42568 |
401 |
SS-Chr 2BN/Mcwi |
renal afferent arteriole diameter |
controlled sodium chloride content diet (1 %) (between 70 and 91 days) then controlled ex vivo artery perfusion pressure (60 mmHg) (for 0.1 hours) |
Miller B, et al., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6. |
kidney arteriole morphology trait |
not specified |
91 days-133 days |
6 |
|
20.7 |
um |
1.8 |
4.41 |
ex vivo videomicroscopy |
renal afferent arteriole |
120.0 |
0 |
ex vivo videomicroscopy (MMO:0000319) |
renal afferent arteriole diameter (CMO:0003725) |
renal arteriole morphology trait |
106505 |
3030 |
SS-Chr 2BN/Mcwi |
absolute change in body temperature |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
12 |
|
0.21 |
degrees C |
0.16 |
0.54 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16022 |
381 |
SS-Chr 2BN/Mcwi |
mean arterial blood pressure |
control condition |
PhysGen Respiratory data |
arterial blood pressure trait |
female |
82 days-99 days |
10 |
|
124.3 |
mmHg |
7.17 |
22.68 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15133 |
381 |
SS-Chr 2BN/Mcwi |
mean arterial blood pressure |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
male |
82 days-99 days |
12 |
|
123.29 |
mmHg |
4.45 |
15.41 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14378 |
381 |
SS-Chr 2BN/Mcwi |
partial pressure of blood carbon dioxide (Pco2) |
resting on treadmill (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
blood carbon dioxide amount |
female |
82 days-99 days |
11 |
|
32.84 |
mmHg |
0.63 |
2.08 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14479 |
381 |
SS-Chr 2BN/Mcwi |
percent change in ventilation |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
13 |
%change=VE during 2-3 min hypoxia/control during standard conditions |
138.21 |
% |
7.07 |
25.5 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13707 |
381 |
SS-Chr 2BN/Mcwi |
mean arterial blood pressure |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
female |
82 days-99 days |
10 |
|
121.23 |
mmHg |
6.91 |
21.84 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14371 |
381 |
SS-Chr 2BN/Mcwi |
minute ventilation |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
12 |
|
74.67 |
ml/min |
4.39 |
15.21 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20788 |
381 |
SS-Chr 2BN/Mcwi |
mean arterial blood pressure |
resting on treadmill (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
female |
82 days-99 days |
12 |
|
120.37 |
mmHg |
3.29 |
11.4 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20062 |
381 |
SS-Chr 2BN/Mcwi |
blood lymphocyte count |
control condition (for 14 days) |
PhysGen Biochemistry data |
lymphocyte quantity |
female |
77 days-91 days |
9 |
|
4.83 |
x 1000 cells/ul |
0.5 |
1.51 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36937 |
401 |
SS-Chr 2BN/Mcwi |
serum alkaline phosphatase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood alkaline phosphatase amount |
male |
77 days-91 days |
15 |
|
249.33 |
U/l |
8.98 |
34.78 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36406 |
401 |
SS-Chr 2BN/Mcwi |
respiration rate |
control condition |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
12 |
|
86.33 |
breaths/min |
4.88 |
16.89 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18433 |
381 |
SS-Chr 2BN/Mcwi |
respiration rate |
control condition |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
13 |
|
89.07 |
breaths/min |
4.06 |
14.66 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18437 |
381 |
SS-Chr 2BN/Mcwi |
urine potassium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine potassium amount |
female |
80 days-99 days |
10 |
|
0.91 |
mEq/d |
0.08 |
0.25 |
flame atomic emission spectrometry |
|
|
0 |
urine potassium analysis |
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52969 |
482 |
SS-Chr 2BN/Mcwi |
mean arterial blood pressure |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
arterial blood pressure trait |
female |
80 days-99 days |
10 |
|
150.38 |
mmHg |
3.4 |
10.75 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52871 |
482 |
SS-Chr 2BN/Mcwi |
heart rate |
air carbon dioxide content (7 %) (for 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
female |
82 days-99 days |
9 |
|
404.44 |
beats/min |
17.49 |
52.47 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14736 |
381 |
SS-Chr 2BN/Mcwi |
mean arterial blood pressure |
air carbon dioxide content (7 %) (for 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
male |
82 days-99 days |
8 |
|
125.46 |
mmHg |
2.88 |
8.14 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13530 |
381 |
SS-Chr 2BN/Mcwi |
partial pressure of blood carbon dioxide (Pco2) |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) |
PhysGen Respiratory data |
blood carbon dioxide amount |
female |
82 days-99 days |
11 |
|
28.35 |
mmHg |
0.76 |
2.52 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13442 |
381 |
SS-Chr 2BN/Mcwi |
tidal volume |
control condition |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
12 |
|
0.31 |
ml |
0.02 |
0.08 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18005 |
381 |
SS-Chr 2BN/Mcwi |
heart rate |
resting on treadmill (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
female |
82 days-99 days |
12 |
|
414.56 |
beats/min |
7.88 |
27.31 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17754 |
381 |
SS-Chr 2BN/Mcwi |
body weight |
control condition |
PhysGen Respiratory data |
body mass |
female |
82 days-99 days |
19 |
|
173.9 |
g |
2.7 |
11.6 |
whole body digital scale |
|
|
0 |
|
|
Moms and pups used in studies were fed Dyets |
17840 |
381 |
SS-Chr 2BN/Mcwi |
body temperature |
control condition |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
12 |
|
37.04 |
degrees C |
0.37 |
1.29 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19096 |
381 |
SS-Chr 2BN/Mcwi |
mean corpuscular hemoglobin concentration |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
9 |
|
32.36 |
g/dl |
0.11 |
0.33 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37396 |
401 |
SS-Chr 2BN/Mcwi |
serum sodium level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood sodium amount |
female |
77 days-91 days |
9 |
|
145.33 |
mmol/l |
0.76 |
2.29 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36558 |
401 |
SS-Chr 2BN/Mcwi |
percent change in ventilation |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
13 |
%change=VE during7-9 min hypercapnia/control during standard conditions |
126.32 |
% |
4.88 |
17.61 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18570 |
381 |
SS-Chr 2BN/Mcwi |
heart rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
9 |
|
167.88 |
beats/min |
8.18 |
24.53 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48972 |
461 |
SS-Chr 2BN/Mcwi |
blood pH |
resting on treadmill (for 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
female |
82 days-99 days |
11 |
|
7.46 |
null |
0.01 |
0.03 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Dyets |
20168 |
381 |
SS-Chr 2BN/Mcwi |
respiration rate |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
12 |
|
97.23 |
breaths/min |
3.3 |
11.42 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18288 |
381 |
SS-Chr 2BN/Mcwi |
left ventricular diastolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
9 |
|
5.75 |
mmHg |
0.15 |
0.46 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49204 |
461 |
SS-Chr 2BN/Mcwi |
heart contraction pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
male |
49 days-63 days |
10 |
|
58.0 |
mmHg |
6.97 |
22.04 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
50024 |
461 |
SS-Chr 2BN/Mcwi |
body weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
body mass |
female |
49 days-63 days |
10 |
|
131.0 |
g |
2.0 |
6.3 |
whole body digital scale |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49577 |
461 |
SS-Chr 2BN/Mcwi |
time to peak heart contraction |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
|
1105.2 |
s |
28.59 |
90.41 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
50254 |
461 |
SS-Chr 2BN/Mcwi |
serum bicarbonate level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood bicarbonate amount |
male |
77 days-91 days |
13 |
|
14.92 |
mmol/l |
0.4 |
1.44 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42089 |
401 |
SS-Chr 2BN/Mcwi |
mean corpuscular volume |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte size trait |
male |
77 days-91 days |
15 |
|
63.15 |
fl |
0.52 |
2.0 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38772 |
401 |
SS-Chr 2BN/Mcwi |
serum aspartate aminotransferase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood aspartate transaminase amount |
female |
77 days-91 days |
10 |
|
85.0 |
U/l |
8.57 |
27.09 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42793 |
401 |
SS-Chr 2BN/Mcwi |
serum sodium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood sodium amount |
male |
77 days-91 days |
15 |
|
146.27 |
mmol/l |
0.48 |
1.87 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39415 |
401 |
SS-Chr 2BN/Mcwi |
mean corpuscular hemoglobin |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
15 |
|
20.1 |
pg |
0.15 |
0.57 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42572 |
401 |
SS-Chr 2BN/Mcwi |
red blood cell count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
male |
77 days-91 days |
15 |
|
9.31 |
x 10E6 cells/ul |
0.15 |
0.57 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39264 |
401 |
SS-Chr 2BN/Mcwi |
percent change in respiration rate |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
13 |
|
118.05 |
% |
5.02 |
18.1 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54354 |
381 |
SS-Chr 2BN/Mcwi |
mean corpuscular hemoglobin concentration |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
15 |
|
31.85 |
g/dl |
0.11 |
0.41 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39804 |
401 |
SS-Chr 2BN/Mcwi |
body weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
body mass |
female |
77 days-91 days |
10 |
|
145.5 |
g |
2.3 |
7.2 |
whole body digital scale |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59085 |
526 |
SS-Chr 2BN/Mcwi |
blood monocyte count |
control condition (for 14 days) |
PhysGen Biochemistry data |
monocyte quantity |
female |
77 days-91 days |
9 |
|
0.3 |
x 1000 cells/ul |
0.07 |
0.2 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40362 |
401 |
SS-Chr 2BN/Mcwi |
serum chloride level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood chloride amount |
female |
77 days-91 days |
9 |
|
103.33 |
mmol/l |
0.47 |
1.41 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40074 |
401 |
SS-Chr 2BN/Mcwi |
serum chloride level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood chloride amount |
male |
77 days-91 days |
6 |
|
105.67 |
mmol/l |
1.05 |
2.58 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40082 |
401 |
SS-Chr 2BN/Mcwi |
blood hemoglobin level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
9 |
|
14.59 |
g/dl |
0.25 |
0.75 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40170 |
401 |
SS-Chr 2BN/Mcwi |
serum alkaline phosphatase activity level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood alkaline phosphatase amount |
female |
77 days-91 days |
9 |
|
142.33 |
U/l |
11.71 |
35.13 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37518 |
401 |
SS-Chr 2BN/Mcwi |
serum phosphate level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood phosphate amount |
male |
77 days-91 days |
15 |
|
8.82 |
mg/dl |
0.14 |
0.54 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37621 |
401 |
SS-Chr 2BN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
male |
77 days-91 days |
10 |
|
1.67 |
mg/kg |
0.37 |
1.18 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59240 |
526 |
SS-Chr 2BN/Mcwi |
serum alanine aminotransferase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood alanine transaminase amount |
male |
77 days-91 days |
15 |
|
52.33 |
U/l |
2.24 |
8.66 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40741 |
401 |
SS-Chr 2BN/Mcwi |
serum urea nitrogen level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood urea nitrogen amount |
male |
77 days-91 days |
12 |
|
20.08 |
mg/dl |
1.22 |
4.21 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40855 |
401 |
SS-Chr 2BN/Mcwi |
lung dry weight to body weight ratio |
control condition (for 14 days) |
PhysGen Lung data |
lung mass |
male |
77 days-91 days |
10 |
|
0.87 |
g/kg |
0.02 |
0.05 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59530 |
526 |
SS-Chr 2BN/Mcwi |
serum glucose level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood glucose amount |
female |
77 days-91 days |
9 |
|
159.33 |
mg/dl |
3.1 |
9.29 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41262 |
401 |
SS-Chr 2BN/Mcwi |
serum total cholesterol level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood cholesterol amount |
male |
77 days-91 days |
6 |
|
81.83 |
mg/dl |
3.32 |
8.13 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38509 |
401 |
SS-Chr 2BN/Mcwi |
blood eosinophil count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
eosinophil quantity |
female |
77 days-91 days |
10 |
|
0.03 |
x 1000 cells/ul |
0.01 |
0.04 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41670 |
401 |
SS-Chr 2BN/Mcwi |
serum urea nitrogen level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood urea nitrogen amount |
male |
77 days-91 days |
6 |
|
15.67 |
mg/dl |
0.71 |
1.75 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41828 |
401 |
SS-Chr 2BN/Mcwi |
percent change in left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
54.93 |
% |
5.3 |
16.76 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48550 |
461 |
SS-Chr 2BN/Mcwi |
percent change in left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
42.51 |
% |
4.93 |
15.6 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48554 |
461 |
SS-Chr 2BN/Mcwi |
red blood cell count |
control condition (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
female |
77 days-91 days |
9 |
|
7.81 |
x 10E6 cells/ul |
0.16 |
0.49 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42037 |
401 |
SS-Chr 2BN/Mcwi |
left ventricular diastolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
|
49.04 |
mmHg |
6.1 |
19.3 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46444 |
461 |
SS-Chr 2BN/Mcwi |
heart wet weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
heart mass |
female |
49 days-63 days |
10 |
|
0.92 |
g |
0.02 |
0.07 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45428 |
461 |
SS-Chr 2BN/Mcwi |
heart wet weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
heart mass |
male |
49 days-63 days |
10 |
|
0.95 |
g |
0.03 |
0.08 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45432 |
461 |
SS-Chr 2BN/Mcwi |
serum total bilirubin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood bilirubin amount |
male |
77 days-91 days |
15 |
|
0.1 |
mg/dl |
0.0 |
0.0 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41895 |
401 |
SS-Chr 2BN/Mcwi |
body weight |
controlled sodium content diet (4 %) (for 21 days) |
PhysGen Vascular data |
body mass |
female |
70 days-84 days |
16 |
|
193.0 |
g |
2.5 |
9.9 |
whole body digital scale |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55236 |
522 |
SS-Chr 2BN/Mcwi |
heart right ventricle weight to left ventricle weight ratio |
control condition (for 14 days) |
PhysGen Lung data |
heart right ventricle mass |
female |
77 days-91 days |
15 |
|
0.22 |
null |
0.02 |
0.08 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57969 |
526 |
SS-Chr 2BN/Mcwi |
minute ventilation |
control condition |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
13 |
|
36.13 |
ml/min |
3.26 |
11.74 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16717 |
381 |
SS-Chr 2BN/Mcwi |
methylene blue to FAPGG metabolism-surface area product ratio |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
16 |
|
0.37 |
null |
0.03 |
0.12 |
isolated perfused lung vascular effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58140 |
526 |
SS-Chr 2BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
16 |
|
0.06 |
umol/l |
0.01 |
0.02 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54963 |
522 |
SS-Chr 2BN/Mcwi |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
14 |
|
0.03 |
10E-7mol/l |
0.01 |
0.03 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56250 |
522 |
SS-Chr 2BN/Mcwi |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
|
-8.41 |
null |
0.2 |
0.62 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56043 |
522 |
SS-Chr 2BN/Mcwi |
calculated pulmonary vascular resistance normalized to body weight |
Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
10 |
|
0.15 |
mmHg x min x kg x ml-1 |
0.01 |
0.04 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59964 |
526 |
SS-Chr 2BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
14 |
|
0.92 |
E-7mole |
0.33 |
1.25 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56577 |
522 |
SS-Chr 2BN/Mcwi |
heart weight to body weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
heart mass |
female |
49 days-63 days |
10 |
|
6.99 |
g/kg |
0.1 |
0.33 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45675 |
461 |
SS-Chr 2BN/Mcwi |
body weight |
control condition |
PhysGen Cardiac data |
body mass |
female |
49 days-63 days |
15 |
|
147.7 |
g |
2.2 |
8.3 |
whole body digital scale |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47872 |
461 |
SS-Chr 2BN/Mcwi |
arterial blood flow rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
15 |
|
5.58 |
ml/min/g |
0.38 |
1.48 |
isolated perfused heart effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46224 |
461 |
SS-Chr 2BN/Mcwi |
left ventricular diastolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
8 |
|
6.11 |
mmHg |
0.15 |
0.42 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47224 |
461 |
SS-Chr 2BN/Mcwi |
percent change in heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
83.27 |
% |
4.0 |
12.65 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48318 |
461 |
SS-Chr 2BN/Mcwi |
percent change in heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
86.63 |
% |
3.63 |
11.47 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48322 |
461 |
SS-Chr 2BN/Mcwi |
left ventricular diastolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
11 |
|
5.4 |
mmHg |
0.39 |
1.3 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49200 |
461 |
SS-Chr 2BN/Mcwi |
absolute change in body temperature |
air carbon dioxide content (7 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
13 |
|
-0.12 |
degrees C |
0.13 |
0.48 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15692 |
381 |
SS-Chr 2BN/Mcwi |
blood pH |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
female |
82 days-99 days |
11 |
|
7.45 |
null |
0.01 |
0.04 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
14612 |
381 |
SS-Chr 2BN/Mcwi |
partial pressure of blood carbon dioxide (Pco2) |
resting on treadmill (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
blood carbon dioxide amount |
male |
82 days-99 days |
12 |
|
34.1 |
mmHg |
0.57 |
1.96 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14484 |
381 |
SS-Chr 2BN/Mcwi |
absolute change in body temperature |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
12 |
|
0.52 |
degrees C |
0.17 |
0.58 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16017 |
381 |
SS-Chr 2BN/Mcwi |
minute ventilation |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
13 |
|
48.77 |
ml/min |
4.43 |
15.97 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18689 |
381 |
SS-Chr 2BN/Mcwi |
plasma creatinine level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
blood creatinine amount |
female |
80 days-99 days |
10 |
|
0.32 |
mg/dl |
0.02 |
0.06 |
radioimmunoassay |
|
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52232 |
482 |
SS-Chr 2BN/Mcwi |
heart rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
15 |
|
219.96 |
beats/min |
11.58 |
44.84 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48220 |
461 |
SS-Chr 2BN/Mcwi |
heart rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
|
201.9 |
beats/min |
9.57 |
30.26 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48224 |
461 |
SS-Chr 2BN/Mcwi |
percent change in heart rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
77.45 |
% |
9.35 |
29.57 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48433 |
461 |
SS-Chr 2BN/Mcwi |
left ventricular diastolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
15 |
|
48.69 |
mmHg |
4.0 |
15.49 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47724 |
461 |
SS-Chr 2BN/Mcwi |
blood eosinophil count |
control condition (for 14 days) |
PhysGen Biochemistry data |
eosinophil quantity |
male |
77 days-91 days |
6 |
|
0.01 |
x 1000 cells/ul |
0.01 |
0.03 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41480 |
401 |
SS-Chr 2BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
9 |
|
-7.3 |
null |
0.07 |
0.22 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56980 |
522 |
SS-Chr 2BN/Mcwi |
body weight |
control condition (for 14 days) |
PhysGen Lung data |
body mass |
female |
77 days-91 days |
15 |
|
164.0 |
g |
5.8 |
22.4 |
whole body digital scale |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58406 |
526 |
SS-Chr 2BN/Mcwi |
plasma anion gap |
control condition (for 14 days) |
PhysGen Biochemistry data |
ion homeostasis trait |
male |
77 days-91 days |
6 |
|
23.83 |
mmol/l |
0.65 |
1.6 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
43207 |
401 |
SS-Chr 2BN/Mcwi |
maximum contractile force per wet weight of aorta |
potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
20 |
|
1.49 |
g/mg |
0.15 |
0.66 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55847 |
522 |
SS-Chr 2BN/Mcwi |
heart left ventricle infarction weight to total heart left ventricle weight ratio |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) |
PhysGen Cardiac data |
heart left ventricle integrity trait |
male |
49 days-63 days |
10 |
|
5.99 |
% |
1.93 |
6.1 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49725 |
461 |
SS-Chr 2BN/Mcwi |
heart right ventricle weight to left ventricle weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
heart right ventricle mass |
female |
77 days-91 days |
10 |
|
0.25 |
null |
0.02 |
0.07 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58756 |
526 |
SS-Chr 2BN/Mcwi |
serum alanine aminotransferase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood alanine transaminase amount |
female |
77 days-91 days |
10 |
|
48.8 |
U/l |
3.92 |
12.38 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40737 |
401 |
SS-Chr 2BN/Mcwi |
hematocrit |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
erythrocyte quantity |
female |
77 days-91 days |
10 |
|
57.17 |
% |
0.47 |
1.49 |
microhematocrit tube assay with visual assessment |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59280 |
526 |
SS-Chr 2BN/Mcwi |
hematocrit |
control condition (for 14 days) |
PhysGen Lung data |
erythrocyte quantity |
male |
77 days-91 days |
8 |
|
45.44 |
% |
0.56 |
1.58 |
microhematocrit tube assay with visual assessment |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57563 |
526 |
SS-Chr 2BN/Mcwi |
fractional change in blood vessel diameter per unit change in intravascular pressure |
Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
blood vessel distensibility trait |
female |
77 days-91 days |
10 |
|
0.04 |
mmHg-1 |
0.01 |
0.02 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59426 |
526 |
SS-Chr 2BN/Mcwi |
serum globulin level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood globulin amount |
female |
77 days-91 days |
9 |
|
2.21 |
g/dl |
0.06 |
0.17 |
standard blood chemistry panel |
|
|
0 |
|
replaced obsolete serum globulin level term, 1/19/2016 |
Moms and pups used in studies were fed Teklad |
41095 |
401 |
SS-Chr 2BN/Mcwi |
partial pressure of blood oxygen |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
female |
82 days-99 days |
11 |
|
112.37 |
mmHg |
1.13 |
3.74 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15058 |
381 |
SS-Chr 2BN/Mcwi |
urine albumin excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine albumin amount |
male |
80 days-99 days |
10 |
|
73.9 |
mg/d |
13.02 |
41.18 |
radioimmunoassay |
|
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52628 |
482 |
SS-Chr 2BN/Mcwi |
heart rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
heart pumping trait |
female |
80 days-99 days |
10 |
|
400.36 |
beats/min |
6.22 |
19.67 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52673 |
482 |
SS-Chr 2BN/Mcwi |
heart rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
heart pumping trait |
male |
80 days-99 days |
9 |
|
397.25 |
beats/min |
8.94 |
26.81 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52679 |
482 |
SS-Chr 2BN/Mcwi |
urine sodium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine sodium amount |
female |
80 days-99 days |
10 |
|
12.32 |
mEq/d |
1.69 |
5.33 |
flame atomic emission spectrometry |
|
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52773 |
482 |
SS-Chr 2BN/Mcwi |
urine sodium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine sodium amount |
male |
80 days-99 days |
10 |
|
18.08 |
mEq/d |
2.1 |
6.64 |
flame atomic emission spectrometry |
|
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52779 |
482 |
SS-Chr 2BN/Mcwi |
heart rate |
air carbon dioxide content (7 %) (for 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
male |
82 days-99 days |
8 |
|
371.2 |
beats/min |
13.44 |
38.01 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14743 |
381 |
SS-Chr 2BN/Mcwi |
absolute change in blood pH |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
female |
82 days-99 days |
10 |
|
-0.01 |
null |
0.01 |
0.02 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14773 |
381 |
SS-Chr 2BN/Mcwi |
absolute change in blood pH |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
male |
82 days-99 days |
12 |
|
-0.03 |
null |
0.01 |
0.05 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14778 |
381 |
SS-Chr 2BN/Mcwi |
partial pressure of blood carbon dioxide (Pco2) |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) |
PhysGen Respiratory data |
blood carbon dioxide amount |
male |
82 days-99 days |
12 |
|
31.0 |
mmHg |
0.74 |
2.56 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13447 |
381 |
SS-Chr 2BN/Mcwi |
absolute change in partial pressure of blood carbon dioxide |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
blood carbon dioxide amount |
male |
82 days-99 days |
12 |
|
-3.09 |
mmHg |
0.67 |
2.32 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20101 |
381 |
SS-Chr 2BN/Mcwi |
mean arterial blood pressure |
control condition |
PhysGen Respiratory data |
arterial blood pressure trait |
female |
82 days-99 days |
8 |
|
129.71 |
mmHg |
6.29 |
17.78 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19904 |
381 |
SS-Chr 2BN/Mcwi |
mean arterial blood pressure |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
female |
82 days-99 days |
11 |
|
128.91 |
mmHg |
3.38 |
11.22 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18955 |
381 |
SS-Chr 2BN/Mcwi |
partial pressure of blood oxygen |
control condition |
PhysGen Respiratory data |
blood oxygen amount |
female |
82 days-99 days |
9 |
|
104.08 |
mmHg |
2.24 |
6.71 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18908 |
381 |
SS-Chr 2BN/Mcwi |
minute ventilation |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
13 |
|
78.41 |
ml/min |
7.3 |
26.32 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14523 |
381 |
SS-Chr 2BN/Mcwi |
blood pH |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
male |
82 days-99 days |
12 |
|
7.45 |
null |
0.02 |
0.05 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
14617 |
381 |
SS-Chr 2BN/Mcwi |
percent change in respiration rate |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
12 |
|
147.93 |
% |
5.89 |
20.4 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54247 |
381 |
SS-Chr 2BN/Mcwi |
respiration rate |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
13 |
|
145.98 |
breaths/min |
5.15 |
18.57 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17134 |
381 |
SS-Chr 2BN/Mcwi |
mean corpuscular hemoglobin concentration |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
6 |
|
32.32 |
g/dl |
0.11 |
0.28 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37404 |
401 |
SS-Chr 2BN/Mcwi |
serum sodium level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood sodium amount |
male |
77 days-91 days |
6 |
|
147.33 |
mmol/l |
0.33 |
0.82 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36566 |
401 |
SS-Chr 2BN/Mcwi |
serum total protein level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood total protein amount |
female |
77 days-91 days |
9 |
|
6.33 |
g/dl |
0.09 |
0.26 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37266 |
401 |
SS-Chr 2BN/Mcwi |
minute ventilation |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
12 |
|
35.35 |
ml/min |
3.28 |
11.35 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18685 |
381 |
SS-Chr 2BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
female |
82 days-99 days |
10 |
|
412.88 |
beats/min |
24.38 |
77.08 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17544 |
381 |
SS-Chr 2BN/Mcwi |
heart rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
15 |
|
188.63 |
beats/min |
7.12 |
27.56 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48968 |
461 |
SS-Chr 2BN/Mcwi |
blood pH |
resting on treadmill (for 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
male |
82 days-99 days |
12 |
|
7.48 |
null |
0.0 |
0.01 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Dyets |
20173 |
381 |
SS-Chr 2BN/Mcwi |
minute ventilation |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
13 |
|
44.29 |
ml/min |
2.89 |
10.43 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20235 |
381 |
SS-Chr 2BN/Mcwi |
respiration rate |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
13 |
|
103.16 |
breaths/min |
2.39 |
8.63 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18292 |
381 |
SS-Chr 2BN/Mcwi |
heart wet weight |
control condition |
PhysGen Cardiac data |
heart mass |
female |
49 days-63 days |
15 |
|
0.77 |
g |
0.03 |
0.11 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49083 |
461 |
SS-Chr 2BN/Mcwi |
heart wet weight |
control condition |
PhysGen Cardiac data |
heart mass |
male |
49 days-63 days |
10 |
|
1.03 |
g |
0.05 |
0.16 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49087 |
461 |
SS-Chr 2BN/Mcwi |
absolute change in body temperature |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
12 |
|
-0.53 |
degrees C |
0.29 |
1.0 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20332 |
381 |
SS-Chr 2BN/Mcwi |
partial pressure of blood oxygen |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
male |
82 days-99 days |
11 |
|
56.5 |
mmHg |
1.41 |
4.69 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20523 |
381 |
SS-Chr 2BN/Mcwi |
mean corpuscular volume |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte size trait |
female |
77 days-91 days |
10 |
|
62.46 |
fl |
0.45 |
1.41 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38768 |
401 |
SS-Chr 2BN/Mcwi |
serum albumin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood albumin amount |
female |
77 days-91 days |
10 |
|
4.08 |
g/dl |
0.03 |
0.09 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42256 |
401 |
SS-Chr 2BN/Mcwi |
serum albumin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood albumin amount |
male |
77 days-91 days |
15 |
|
3.76 |
g/dl |
0.04 |
0.14 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42260 |
401 |
SS-Chr 2BN/Mcwi |
blood neutrophil count |
control condition (for 14 days) |
PhysGen Biochemistry data |
neutrophil quantity |
male |
77 days-91 days |
6 |
|
0.81 |
x 1000 cells/ul |
0.16 |
0.38 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38972 |
401 |
SS-Chr 2BN/Mcwi |
serum aspartate aminotransferase activity level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood aspartate transaminase amount |
female |
77 days-91 days |
9 |
|
69.56 |
U/l |
5.06 |
15.17 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42485 |
401 |
SS-Chr 2BN/Mcwi |
blood neutrophil count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
neutrophil quantity |
female |
77 days-91 days |
10 |
|
0.46 |
x 1000 cells/ul |
0.09 |
0.28 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
43247 |
401 |
SS-Chr 2BN/Mcwi |
blood hemoglobin level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
6 |
|
14.62 |
g/dl |
0.2 |
0.49 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40178 |
401 |
SS-Chr 2BN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
male |
77 days-91 days |
11 |
|
1.73 |
mg/kg |
0.14 |
0.46 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58933 |
526 |
SS-Chr 2BN/Mcwi |
mean corpuscular hemoglobin |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
6 |
|
18.9 |
pg |
0.12 |
0.3 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40274 |
401 |
SS-Chr 2BN/Mcwi |
blood monocyte count |
control condition (for 14 days) |
PhysGen Biochemistry data |
monocyte quantity |
male |
77 days-91 days |
6 |
|
0.54 |
x 1000 cells/ul |
0.14 |
0.35 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40370 |
401 |
SS-Chr 2BN/Mcwi |
serum urea nitrogen level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood urea nitrogen amount |
female |
77 days-91 days |
10 |
|
23.5 |
mg/dl |
0.83 |
2.64 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40851 |
401 |
SS-Chr 2BN/Mcwi |
total white blood cell count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
leukocyte quantity |
male |
77 days-91 days |
15 |
|
7.63 |
x 1000 cells/ul |
0.42 |
1.64 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40953 |
401 |
SS-Chr 2BN/Mcwi |
blood hemoglobin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
15 |
|
18.7 |
g/dl |
0.28 |
1.09 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37995 |
401 |
SS-Chr 2BN/Mcwi |
blood lymphocyte count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
lymphocyte quantity |
male |
77 days-91 days |
15 |
|
5.73 |
x 1000 cells/ul |
0.32 |
1.25 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41530 |
401 |
SS-Chr 2BN/Mcwi |
plasma anion gap |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
ion homeostasis trait |
female |
77 days-91 days |
10 |
|
24.8 |
mmol/l |
0.66 |
2.1 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38284 |
401 |
SS-Chr 2BN/Mcwi |
heart effluent lactate dehydrogenase activity level normalized to heart weight |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart lactate dehydrogenase activity |
male |
49 days-63 days |
10 |
|
0.54 |
IU/g |
0.09 |
0.3 |
isolated perfused heart effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47510 |
461 |
SS-Chr 2BN/Mcwi |
time to peak heart contraction |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
|
1233.9 |
s |
62.94 |
199.04 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46575 |
461 |
SS-Chr 2BN/Mcwi |
serum total bilirubin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood bilirubin amount |
female |
77 days-91 days |
10 |
|
0.11 |
mg/dl |
0.01 |
0.03 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41891 |
401 |
SS-Chr 2BN/Mcwi |
hematocrit |
control condition (for 14 days) |
PhysGen Lung data |
erythrocyte quantity |
female |
77 days-91 days |
11 |
|
45.83 |
% |
0.88 |
2.93 |
microhematocrit tube assay with visual assessment |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57555 |
526 |
SS-Chr 2BN/Mcwi |
methylene blue metabolism-surface area product after auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
11.62 |
ml/min/kg |
1.2 |
3.78 |
isolated perfused lung vascular effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57621 |
526 |
SS-Chr 2BN/Mcwi |
heart right ventricle weight to left ventricle weight ratio |
control condition (for 14 days) |
PhysGen Lung data |
heart right ventricle mass |
male |
77 days-91 days |
10 |
|
0.17 |
null |
0.01 |
0.03 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57977 |
526 |
SS-Chr 2BN/Mcwi |
partial pressure of blood oxygen |
resting on treadmill (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
female |
82 days-99 days |
11 |
|
100.09 |
mmHg |
1.26 |
4.17 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16413 |
381 |
SS-Chr 2BN/Mcwi |
methylene blue metabolism-surface area product without auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
16 |
|
13.41 |
ml/min/kg |
0.86 |
3.43 |
isolated perfused lung vascular effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57827 |
526 |
SS-Chr 2BN/Mcwi |
absolute change in partial pressure of blood oxygen |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
female |
82 days-99 days |
10 |
|
11.48 |
mmHg |
1.71 |
5.39 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16299 |
381 |
SS-Chr 2BN/Mcwi |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
11 |
|
0.03 |
10E-7mol/l |
0.01 |
0.02 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55755 |
522 |
SS-Chr 2BN/Mcwi |
body temperature |
control condition |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
12 |
|
37.63 |
degrees C |
0.21 |
0.72 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16835 |
381 |
SS-Chr 2BN/Mcwi |
body temperature |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
13 |
|
37.38 |
degrees C |
0.12 |
0.42 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16599 |
381 |
SS-Chr 2BN/Mcwi |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
11 |
|
-8.57 |
null |
0.09 |
0.3 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54629 |
522 |
SS-Chr 2BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
19 |
|
0.05 |
umol/l |
0.01 |
0.02 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54733 |
522 |
SS-Chr 2BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
10 |
|
0.04 |
umol/l |
0.01 |
0.03 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54971 |
522 |
SS-Chr 2BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
10 |
|
-7.52 |
null |
0.1 |
0.32 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56170 |
522 |
SS-Chr 2BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
16 |
|
29.25 |
% |
2.55 |
10.18 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55064 |
522 |
SS-Chr 2BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
|
16.4 |
% |
0.97 |
3.06 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55098 |
522 |
SS-Chr 2BN/Mcwi |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
11 |
|
99.55 |
% |
0.28 |
0.93 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56485 |
522 |
SS-Chr 2BN/Mcwi |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
12 |
|
98.08 |
% |
0.98 |
3.4 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56490 |
522 |
SS-Chr 2BN/Mcwi |
heart right ventricle weight to left ventricle weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
heart right ventricle mass |
male |
77 days-91 days |
16 |
|
0.34 |
null |
0.03 |
0.1 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58760 |
526 |
SS-Chr 2BN/Mcwi |
methylene blue metabolism-surface area product after auto-oxidation |
methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
16.45 |
ml/min/kg |
1.26 |
3.99 |
isolated perfused lung vascular effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
60062 |
526 |
SS-Chr 2BN/Mcwi |
arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
10 |
|
14.1 |
ml/min/g |
1.29 |
4.07 |
isolated perfused heart effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46676 |
461 |
SS-Chr 2BN/Mcwi |
arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
10 |
|
12.68 |
ml/min/g |
0.99 |
3.13 |
isolated perfused heart effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46680 |
461 |
SS-Chr 2BN/Mcwi |
arterial blood flow rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
10 |
|
11.08 |
ml/min/g |
0.8 |
2.52 |
isolated perfused heart effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46897 |
461 |
SS-Chr 2BN/Mcwi |
arterial blood flow rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
9 |
|
6.65 |
ml/min/g |
0.58 |
1.74 |
isolated perfused heart effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46228 |
461 |
SS-Chr 2BN/Mcwi |
left ventricular developed pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
15 |
|
59.16 |
mmHg |
3.71 |
14.38 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47934 |
461 |
SS-Chr 2BN/Mcwi |
urine total protein excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
total urine protein amount |
male |
80 days-99 days |
10 |
|
174.3 |
mg/d |
23.06 |
72.93 |
automated urine total protein analysis |
|
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52728 |
482 |
SS-Chr 2BN/Mcwi |
absolute change in mean arterial blood pressure |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
female |
82 days-99 days |
11 |
|
8.53 |
mmHg |
2.1 |
6.96 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20740 |
381 |
SS-Chr 2BN/Mcwi |
percent change in tidal volume |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
13 |
|
117.6 |
% |
4.88 |
17.61 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
53913 |
381 |
SS-Chr 2BN/Mcwi |
minute ventilation |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
12 |
|
83.97 |
ml/min |
5.76 |
19.97 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14527 |
381 |
SS-Chr 2BN/Mcwi |
body temperature |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
12 |
|
37.91 |
degrees C |
0.19 |
0.67 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17656 |
381 |
SS-Chr 2BN/Mcwi |
heart rate |
control condition |
PhysGen Respiratory data |
heart pumping trait |
male |
82 days-99 days |
8 |
|
424.03 |
beats/min |
15.3 |
43.29 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15973 |
381 |
SS-Chr 2BN/Mcwi |
partial pressure of blood oxygen |
control condition |
PhysGen Respiratory data |
blood oxygen amount |
male |
82 days-99 days |
11 |
|
104.17 |
mmHg |
1.23 |
4.07 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18915 |
381 |
SS-Chr 2BN/Mcwi |
serum total protein level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood total protein amount |
male |
77 days-91 days |
6 |
|
6.2 |
g/dl |
0.09 |
0.22 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37274 |
401 |
SS-Chr 2BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
10 |
|
1.53 |
ml/min |
0.14 |
0.44 |
urine creatinine analysis |
|
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52183 |
482 |
SS-Chr 2BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
9 |
|
2.27 |
ml/min |
0.15 |
0.46 |
urine creatinine analysis |
|
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52189 |
482 |
SS-Chr 2BN/Mcwi |
heart effluent lactate dehydrogenase activity level normalized to heart weight |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart lactate dehydrogenase activity |
female |
49 days-63 days |
13 |
|
0.29 |
IU/g |
0.05 |
0.17 |
isolated perfused heart effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47365 |
461 |
SS-Chr 2BN/Mcwi |
left ventricular diastolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
9 |
|
46.47 |
mmHg |
6.32 |
18.96 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47728 |
461 |
SS-Chr 2BN/Mcwi |
percent change in left ventricular systolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
77.62 |
% |
9.37 |
29.62 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
44945 |
461 |
SS-Chr 2BN/Mcwi |
blood eosinophil count |
control condition (for 14 days) |
PhysGen Biochemistry data |
eosinophil quantity |
female |
77 days-91 days |
9 |
|
0.02 |
x 1000 cells/ul |
0.02 |
0.05 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41472 |
401 |
SS-Chr 2BN/Mcwi |
minute ventilation |
control condition |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
12 |
|
26.73 |
ml/min |
2.24 |
7.77 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16713 |
381 |
SS-Chr 2BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
16 |
|
56.69 |
% |
2.26 |
9.03 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57192 |
522 |
SS-Chr 2BN/Mcwi |
serum potassium level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood potassium amount |
female |
77 days-91 days |
9 |
|
4.02 |
mmol/l |
0.13 |
0.39 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
43395 |
401 |
SS-Chr 2BN/Mcwi |
serum potassium level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood potassium amount |
male |
77 days-91 days |
6 |
|
4.03 |
mmol/l |
0.2 |
0.48 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
43403 |
401 |
SS-Chr 2BN/Mcwi |
time to peak heart contraction |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
15 |
|
1193.93 |
s |
35.63 |
137.99 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46571 |
461 |
SS-Chr 2BN/Mcwi |
left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
|
115.87 |
mmHg |
11.06 |
34.98 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49911 |
461 |
SS-Chr 2BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
15 |
|
36.0 |
% |
4.72 |
18.29 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55093 |
522 |
SS-Chr 2BN/Mcwi |
percent change in left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
80.56 |
% |
4.79 |
15.15 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48779 |
461 |
SS-Chr 2BN/Mcwi |
heart effluent lactate dehydrogenase activity level normalized to heart weight |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart lactate dehydrogenase activity |
female |
49 days-63 days |
10 |
|
0.44 |
IU/g |
0.11 |
0.35 |
isolated perfused heart effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47502 |
461 |
SS-Chr 2BN/Mcwi |
serum phosphate level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood phosphate amount |
female |
77 days-91 days |
10 |
|
8.44 |
mg/dl |
0.28 |
0.9 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37617 |
401 |
SS-Chr 2BN/Mcwi |
calculated pulmonary vascular resistance normalized to body weight |
controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
0.16 |
mmHg x min x kg x ml-1 |
0.01 |
0.02 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59570 |
526 |
SS-Chr 2BN/Mcwi |
tidal volume |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
13 |
|
0.44 |
ml |
0.02 |
0.09 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15260 |
381 |
SS-Chr 2BN/Mcwi |
tidal volume |
control condition |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
13 |
|
0.29 |
ml |
0.03 |
0.1 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15420 |
381 |
SS-Chr 2BN/Mcwi |
urine potassium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine potassium amount |
male |
80 days-99 days |
10 |
|
1.47 |
mEq/d |
0.18 |
0.58 |
flame atomic emission spectrometry |
|
|
0 |
urine potassium analysis |
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52975 |
482 |
SS-Chr 2BN/Mcwi |
percent change in ventilation |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
12 |
%change=VE during7-9 min hypercapnia/control during standard conditions |
247.55 |
% |
11.75 |
40.7 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14225 |
381 |
SS-Chr 2BN/Mcwi |
percent change in tidal volume |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
12 |
|
103.24 |
% |
5.3 |
18.37 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54011 |
381 |
SS-Chr 2BN/Mcwi |
percent change in respiration rate |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
13 |
|
115.01 |
% |
2.92 |
10.54 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
53781 |
381 |
SS-Chr 2BN/Mcwi |
absolute change in blood pH |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
female |
82 days-99 days |
9 |
|
0.05 |
null |
0.01 |
0.02 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19824 |
381 |
SS-Chr 2BN/Mcwi |
heart rate |
control condition |
PhysGen Respiratory data |
heart pumping trait |
male |
82 days-99 days |
12 |
|
432.93 |
beats/min |
14.79 |
51.24 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20969 |
381 |
SS-Chr 2BN/Mcwi |
blood lymphocyte count |
control condition (for 14 days) |
PhysGen Biochemistry data |
lymphocyte quantity |
male |
77 days-91 days |
6 |
|
4.76 |
x 1000 cells/ul |
0.5 |
1.23 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36945 |
401 |
SS-Chr 2BN/Mcwi |
respiration rate |
control condition |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
13 |
|
89.12 |
breaths/min |
4.55 |
16.42 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14958 |
381 |
SS-Chr 2BN/Mcwi |
percent change in tidal volume |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
13 |
|
174.66 |
% |
6.01 |
21.66 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54110 |
381 |
SS-Chr 2BN/Mcwi |
percent change in tidal volume |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
12 |
|
171.84 |
% |
4.45 |
15.42 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54113 |
381 |
SS-Chr 2BN/Mcwi |
tidal volume |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
12 |
|
0.36 |
ml |
0.03 |
0.1 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13946 |
381 |
SS-Chr 2BN/Mcwi |
percent change in ventilation |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
12 |
%change=VE during 2-3 min hypoxia/control during standard conditions |
132.84 |
% |
6.34 |
21.95 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13703 |
381 |
SS-Chr 2BN/Mcwi |
respiration rate |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
12 |
|
152.28 |
breaths/min |
5.6 |
19.41 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16938 |
381 |
SS-Chr 2BN/Mcwi |
blood pH |
control condition |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
female |
82 days-99 days |
9 |
|
7.47 |
null |
0.01 |
0.04 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20663 |
381 |
SS-Chr 2BN/Mcwi |
serum calcium level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood calcium amount |
female |
77 days-91 days |
9 |
|
9.39 |
mg/dl |
0.16 |
0.49 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36827 |
401 |
SS-Chr 2BN/Mcwi |
absolute change in partial pressure of blood oxygen |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
male |
82 days-99 days |
11 |
|
-47.67 |
mmHg |
1.24 |
4.1 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19511 |
381 |
SS-Chr 2BN/Mcwi |
partial pressure of blood oxygen |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
female |
82 days-99 days |
9 |
|
56.06 |
mmHg |
1.74 |
5.22 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20516 |
381 |
SS-Chr 2BN/Mcwi |
serum calcium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood calcium amount |
male |
77 days-91 days |
12 |
|
9.47 |
mg/dl |
0.11 |
0.37 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36651 |
401 |
SS-Chr 2BN/Mcwi |
absolute change in body temperature |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
13 |
|
0.05 |
degrees C |
0.14 |
0.51 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20336 |
381 |
SS-Chr 2BN/Mcwi |
body weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
body mass |
male |
49 days-63 days |
10 |
|
154.1 |
g |
4.4 |
14.0 |
whole body digital scale |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49585 |
461 |
SS-Chr 2BN/Mcwi |
blood neutrophil count |
control condition (for 14 days) |
PhysGen Biochemistry data |
neutrophil quantity |
female |
77 days-91 days |
9 |
|
0.53 |
x 1000 cells/ul |
0.12 |
0.36 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38964 |
401 |
SS-Chr 2BN/Mcwi |
serum chloride level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood chloride amount |
female |
77 days-91 days |
10 |
|
109.5 |
mmol/l |
0.48 |
1.51 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39140 |
401 |
SS-Chr 2BN/Mcwi |
total white blood cell count |
control condition (for 14 days) |
PhysGen Biochemistry data |
leukocyte quantity |
male |
77 days-91 days |
6 |
|
6.12 |
x 1000 cells/ul |
0.7 |
1.7 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39961 |
401 |
SS-Chr 2BN/Mcwi |
percent change in tidal volume |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
12 |
|
167.35 |
% |
4.74 |
16.42 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54453 |
381 |
SS-Chr 2BN/Mcwi |
mean corpuscular hemoglobin concentration |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
10 |
|
32.0 |
g/dl |
0.16 |
0.51 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39800 |
401 |
SS-Chr 2BN/Mcwi |
plasma creatinine level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood creatinine amount |
male |
77 days-91 days |
14 |
|
0.27 |
mg/dl |
0.02 |
0.06 |
automated plasma creatinine analysis |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39603 |
401 |
SS-Chr 2BN/Mcwi |
mean corpuscular hemoglobin |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
9 |
|
18.72 |
pg |
0.08 |
0.23 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40266 |
401 |
SS-Chr 2BN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
female |
77 days-91 days |
7 |
|
1.54 |
mg/kg |
0.23 |
0.62 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58929 |
526 |
SS-Chr 2BN/Mcwi |
percent change in respiration rate |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
13 |
|
182.78 |
% |
9.48 |
34.16 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
53659 |
381 |
SS-Chr 2BN/Mcwi |
body weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
body mass |
male |
77 days-91 days |
16 |
|
210.1 |
g |
7.5 |
30.0 |
whole body digital scale |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59089 |
526 |
SS-Chr 2BN/Mcwi |
blood monocyte count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
monocyte quantity |
female |
77 days-91 days |
10 |
|
0.36 |
x 1000 cells/ul |
0.06 |
0.19 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39697 |
401 |
SS-Chr 2BN/Mcwi |
hematocrit |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
erythrocyte quantity |
male |
77 days-91 days |
15 |
|
58.69 |
% |
0.92 |
3.58 |
microhematocrit tube assay with visual assessment |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59284 |
526 |
SS-Chr 2BN/Mcwi |
serum globulin level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood globulin amount |
male |
77 days-91 days |
6 |
|
2.25 |
g/dl |
0.08 |
0.19 |
standard blood chemistry panel |
|
|
0 |
|
replaced obsolete serum globulin level term, 1/19/2016 |
Moms and pups used in studies were fed Teklad |
41103 |
401 |
SS-Chr 2BN/Mcwi |
serum alanine aminotransferase activity level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood alanine transaminase amount |
female |
77 days-91 days |
9 |
|
45.0 |
U/l |
3.58 |
10.74 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37775 |
401 |
SS-Chr 2BN/Mcwi |
serum potassium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood potassium amount |
male |
77 days-91 days |
9 |
|
5.27 |
mmol/l |
0.22 |
0.65 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38093 |
401 |
SS-Chr 2BN/Mcwi |
blood hemoglobin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
10 |
|
18.3 |
g/dl |
0.21 |
0.67 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37991 |
401 |
SS-Chr 2BN/Mcwi |
serum phosphate level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood phosphate amount |
female |
77 days-91 days |
9 |
|
8.18 |
mg/dl |
0.31 |
0.93 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37895 |
401 |
SS-Chr 2BN/Mcwi |
calculated pulmonary vascular resistance normalized to body weight |
controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
16 |
|
0.18 |
mmHg x min x kg x ml-1 |
0.01 |
0.04 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59574 |
526 |
SS-Chr 2BN/Mcwi |
serum glucose level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood glucose amount |
female |
77 days-91 days |
10 |
|
148.7 |
mg/dl |
5.96 |
18.84 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38553 |
401 |
SS-Chr 2BN/Mcwi |
body weight |
controlled sodium content diet (4 %) (for 21 days) |
PhysGen Vascular data |
body mass |
male |
70 days-84 days |
10 |
|
277.2 |
g |
3.2 |
10.0 |
whole body digital scale |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55244 |
522 |
SS-Chr 2BN/Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
16 |
|
1.34 |
g/mg |
0.11 |
0.44 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57391 |
522 |
SS-Chr 2BN/Mcwi |
minute ventilation |
control condition |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
12 |
|
30.85 |
ml/min |
2.19 |
7.57 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16174 |
381 |
SS-Chr 2BN/Mcwi |
absolute change in partial pressure of blood oxygen |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
male |
82 days-99 days |
12 |
|
6.53 |
mmHg |
2.2 |
7.63 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16304 |
381 |
SS-Chr 2BN/Mcwi |
body weight |
control condition (for 21 days) |
PhysGen Vascular data |
body mass |
male |
70 days-84 days |
19 |
|
287.1 |
g |
6.1 |
26.6 |
whole body digital scale |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55481 |
522 |
SS-Chr 2BN/Mcwi |
FAPGG metabolism-surface area product |
FAPGG (0.6 mmol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
78.53 |
ml/min/kg |
7.76 |
24.53 |
isolated perfused lung vascular effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58294 |
526 |
SS-Chr 2BN/Mcwi |
FAPGG metabolism-surface area product |
FAPGG (0.6 mmol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
10 |
|
45.56 |
ml/min/kg |
6.69 |
21.15 |
isolated perfused lung vascular effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58302 |
526 |
SS-Chr 2BN/Mcwi |
methylene blue to FAPGG metabolism-surface area product ratio |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
0.25 |
null |
0.04 |
0.11 |
isolated perfused lung vascular effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58136 |
526 |
SS-Chr 2BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
18 |
|
0.06 |
umol/l |
0.01 |
0.06 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54741 |
522 |
SS-Chr 2BN/Mcwi |
fractional change in blood vessel diameter per unit change in intravascular pressure |
controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
blood vessel distensibility trait |
female |
77 days-91 days |
10 |
|
0.02 |
mmHg-1 |
0.0 |
0.01 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58512 |
526 |
SS-Chr 2BN/Mcwi |
fractional change in blood vessel diameter per unit change in intravascular pressure |
controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
blood vessel distensibility trait |
male |
77 days-91 days |
16 |
|
0.03 |
mmHg-1 |
0.0 |
0.01 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58516 |
526 |
SS-Chr 2BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
9 |
|
0.56 |
E-7mole |
0.09 |
0.28 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56585 |
522 |
SS-Chr 2BN/Mcwi |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
|
90.7 |
% |
3.32 |
10.5 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56330 |
522 |
SS-Chr 2BN/Mcwi |
methylene blue metabolism-surface area product without auto-oxidation |
methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
19.88 |
ml/min/kg |
1.94 |
6.13 |
isolated perfused lung vascular effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58691 |
526 |
SS-Chr 2BN/Mcwi |
methylene blue metabolism-surface area product without auto-oxidation |
methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
9 |
|
10.25 |
ml/min/kg |
1.1 |
3.29 |
isolated perfused lung vascular effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58699 |
526 |
SS-Chr 2BN/Mcwi |
methylene blue to FAPGG metabolism-surface area product ratio |
methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
0.27 |
null |
0.04 |
0.11 |
isolated perfused lung vascular effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59840 |
526 |
SS-Chr 2BN/Mcwi |
methylene blue metabolism-surface area product after auto-oxidation |
methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
9 |
|
9.8 |
ml/min/kg |
1.1 |
3.29 |
isolated perfused lung vascular effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
60070 |
526 |
SS-Chr 2BN/Mcwi |
body weight |
control condition |
PhysGen Cardiac data |
body mass |
male |
49 days-63 days |
10 |
|
222.4 |
g |
4.9 |
15.6 |
whole body digital scale |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47880 |
461 |
SS-Chr 2BN/Mcwi |
percent change in arterial blood flow rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
15 |
post-ischemic value/pre-ischemic value x 100% |
50.28 |
% |
4.11 |
15.91 |
isolated perfused heart effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46089 |
461 |
SS-Chr 2BN/Mcwi |
percent change in arterial blood flow rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
57.46 |
% |
9.24 |
29.22 |
isolated perfused heart effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46093 |
461 |
SS-Chr 2BN/Mcwi |
left ventricular systolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
9 |
|
117.18 |
mmHg |
7.53 |
22.58 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
44842 |
461 |
SS-Chr 2BN/Mcwi |
percent change in arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
52.88 |
% |
4.88 |
15.43 |
isolated perfused heart effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47104 |
461 |
SS-Chr 2BN/Mcwi |
left ventricular diastolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
8 |
|
6.39 |
mmHg |
0.15 |
0.44 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47220 |
461 |
SS-Chr 2BN/Mcwi |
heart weight to body weight ratio |
control condition |
PhysGen Cardiac data |
heart mass |
female |
49 days-63 days |
15 |
|
5.23 |
g/kg |
0.16 |
0.62 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47050 |
461 |
SS-Chr 2BN/Mcwi |
heart weight to body weight ratio |
control condition |
PhysGen Cardiac data |
heart mass |
male |
49 days-63 days |
10 |
|
4.63 |
g/kg |
0.18 |
0.58 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47058 |
461 |
SS-Chr 2BN/Mcwi |
percent change in arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
52.52 |
% |
3.24 |
10.24 |
isolated perfused heart effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47100 |
461 |
SS-Chr 2BN/Mcwi |
left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
|
74.56 |
mmHg |
9.82 |
31.06 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45293 |
461 |
SS-Chr 2BN/Mcwi |
tidal volume |
control condition |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
13 |
|
0.4 |
ml |
0.03 |
0.11 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18009 |
381 |
SS-Chr 2BN/Mcwi |
partial pressure of blood carbon dioxide (Pco2) |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood gas amount |
female |
82 days-99 days |
9 |
|
27.26 |
mmHg |
1.04 |
3.12 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17281 |
381 |
SS-Chr 2BN/Mcwi |
body temperature |
air carbon dioxide content (7 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
12 |
|
36.96 |
degrees C |
0.34 |
1.17 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13586 |
381 |
SS-Chr 2BN/Mcwi |
blood pH |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
male |
82 days-99 days |
11 |
|
7.5 |
null |
0.01 |
0.03 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
17094 |
381 |
SS-Chr 2BN/Mcwi |
serum total protein level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood total protein amount |
female |
77 days-91 days |
10 |
|
6.36 |
g/dl |
0.15 |
0.46 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36985 |
401 |
SS-Chr 2BN/Mcwi |
percent change in ventilation |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
12 |
%change=VE during7-9 min hypercapnia/control during standard conditions |
124.64 |
% |
7.16 |
24.8 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18566 |
381 |
SS-Chr 2BN/Mcwi |
tidal volume |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
13 |
|
0.47 |
ml |
0.04 |
0.14 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13950 |
381 |
SS-Chr 2BN/Mcwi |
urine albumin excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
urine albumin amount |
female |
80 days-99 days |
10 |
|
13.96 |
mg/d |
1.96 |
6.2 |
radioimmunoassay |
|
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52622 |
482 |
SS-Chr 2BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
|
198.22 |
beats/min |
8.25 |
26.1 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45175 |
461 |
SS-Chr 2BN/Mcwi |
percent change in heart rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
15 |
post-ischemic value/pre-ischemic value x 100% |
87.42 |
% |
3.31 |
12.84 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48429 |
461 |
SS-Chr 2BN/Mcwi |
plasma creatinine level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood creatinine amount |
female |
77 days-91 days |
10 |
|
0.28 |
mg/dl |
0.03 |
0.09 |
automated plasma creatinine analysis |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39599 |
401 |
SS-Chr 2BN/Mcwi |
serum bicarbonate level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood bicarbonate amount |
male |
77 days-91 days |
6 |
|
21.83 |
mmol/l |
0.31 |
0.75 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
43066 |
401 |
SS-Chr 2BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
15 |
|
53.47 |
% |
3.3 |
12.79 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57156 |
522 |
SS-Chr 2BN/Mcwi |
time to onset of heart contraction |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
female |
49 days-63 days |
10 |
|
846.4 |
s |
64.88 |
205.18 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49322 |
461 |
SS-Chr 2BN/Mcwi |
time to onset of heart contraction |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
male |
49 days-63 days |
10 |
|
904.2 |
s |
30.66 |
96.96 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49326 |
461 |
SS-Chr 2BN/Mcwi |
serum glucose level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood glucose amount |
male |
77 days-91 days |
15 |
|
158.47 |
mg/dl |
5.61 |
21.74 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38557 |
401 |
SS-Chr 2BN/Mcwi |
body weight |
control condition (for 14 days) |
PhysGen Lung data |
body mass |
male |
77 days-91 days |
10 |
|
234.7 |
g |
4.6 |
14.6 |
whole body digital scale |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58414 |
526 |
SS-Chr 2BN/Mcwi |
left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
|
117.19 |
mmHg |
14.7 |
46.47 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49915 |
461 |
SS-Chr 2BN/Mcwi |
left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
7 |
|
155.92 |
mmHg |
10.04 |
26.56 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48651 |
461 |
SS-Chr 2BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
15 |
|
34.6 |
% |
4.62 |
17.89 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56293 |
522 |
SS-Chr 2BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
16 |
|
35.5 |
% |
3.44 |
13.78 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55069 |
522 |
SS-Chr 2BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
15 |
|
48.4 |
% |
4.84 |
18.76 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57291 |
522 |
SS-Chr 2BN/Mcwi |
methylene blue metabolism-surface area product after auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
16 |
|
11.32 |
ml/min/kg |
0.47 |
1.9 |
isolated perfused lung vascular effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57625 |
526 |
SS-Chr 2BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
19 |
|
-7.37 |
null |
0.05 |
0.2 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
55334 |
522 |
SS-Chr 2BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
18 |
|
-7.39 |
null |
0.1 |
0.41 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
55342 |
522 |
SS-Chr 2BN/Mcwi |
tidal volume |
control condition |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
12 |
|
0.32 |
ml |
0.02 |
0.06 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15424 |
381 |
SS-Chr 2BN/Mcwi |
heart rate |
control condition |
PhysGen Respiratory data |
heart pumping trait |
female |
82 days-99 days |
8 |
|
426.12 |
beats/min |
15.9 |
44.97 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15966 |
381 |
SS-Chr 2BN/Mcwi |
tidal volume |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
12 |
|
0.32 |
ml |
0.03 |
0.09 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15256 |
381 |
SS-Chr 2BN/Mcwi |
partial pressure of blood oxygen |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
male |
82 days-99 days |
12 |
|
107.43 |
mmHg |
2.53 |
8.76 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15063 |
381 |
SS-Chr 2BN/Mcwi |
plasma renin activity level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
renin activity |
male |
80 days-99 days |
9 |
|
0.58 |
ng/ml/h |
0.1 |
0.29 |
radioimmunoassay |
|
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52483 |
482 |
SS-Chr 2BN/Mcwi |
body temperature |
air carbon dioxide content (7 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
13 |
|
37.45 |
degrees C |
0.11 |
0.39 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13582 |
381 |
SS-Chr 2BN/Mcwi |
respiration rate |
control condition |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
12 |
|
95.9 |
breaths/min |
4.33 |
15.0 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14962 |
381 |
SS-Chr 2BN/Mcwi |
partial pressure of blood carbon dioxide (Pco2) |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood gas amount |
male |
82 days-99 days |
11 |
|
27.69 |
mmHg |
1.06 |
3.5 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17288 |
381 |
SS-Chr 2BN/Mcwi |
respiration rate |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
12 |
|
139.49 |
breaths/min |
3.19 |
11.06 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17138 |
381 |
SS-Chr 2BN/Mcwi |
heart rate |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
male |
82 days-99 days |
9 |
|
494.15 |
beats/min |
12.46 |
37.38 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13816 |
381 |
SS-Chr 2BN/Mcwi |
absolute change in partial pressure of blood carbon dioxide |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
blood carbon dioxide amount |
female |
82 days-99 days |
10 |
|
-4.2 |
mmHg |
0.57 |
1.81 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20096 |
381 |
SS-Chr 2BN/Mcwi |
absolute change in mean arterial blood pressure |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
male |
82 days-99 days |
9 |
|
13.51 |
mmHg |
1.67 |
5.0 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20745 |
381 |
SS-Chr 2BN/Mcwi |
absolute change in partial pressure of blood carbon dioxide |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood carbon dioxide amount |
female |
82 days-99 days |
9 |
|
-5.97 |
mmHg |
0.73 |
2.2 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19673 |
381 |
SS-Chr 2BN/Mcwi |
absolute change in partial pressure of blood carbon dioxide |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood carbon dioxide amount |
male |
82 days-99 days |
11 |
|
-4.61 |
mmHg |
0.42 |
1.39 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19680 |
381 |
SS-Chr 2BN/Mcwi |
mean arterial blood pressure |
resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
male |
82 days-99 days |
9 |
|
141.27 |
mmHg |
4.76 |
14.29 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18960 |
381 |
SS-Chr 2BN/Mcwi |
serum alkaline phosphatase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood alkaline phosphatase amount |
female |
77 days-91 days |
10 |
|
160.9 |
U/l |
9.51 |
30.06 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36402 |
401 |
SS-Chr 2BN/Mcwi |
serum total protein level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood total protein amount |
male |
77 days-91 days |
15 |
|
6.51 |
g/dl |
0.13 |
0.49 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36989 |
401 |
SS-Chr 2BN/Mcwi |
serum total cholesterol level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood cholesterol amount |
male |
77 days-91 days |
15 |
|
79.93 |
mg/dl |
1.96 |
7.59 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37124 |
401 |
SS-Chr 2BN/Mcwi |
serum calcium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood calcium amount |
female |
77 days-91 days |
10 |
|
9.01 |
mg/dl |
0.11 |
0.34 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36647 |
401 |
SS-Chr 2BN/Mcwi |
absolute change in partial pressure of blood oxygen |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
female |
82 days-99 days |
9 |
|
-48.02 |
mmHg |
1.86 |
5.59 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19504 |
381 |
SS-Chr 2BN/Mcwi |
time to peak heart contraction |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
10 |
|
1140.1 |
s |
35.39 |
111.91 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
50250 |
461 |
SS-Chr 2BN/Mcwi |
heart left ventricle infarction weight to total heart left ventricle weight ratio |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) |
PhysGen Cardiac data |
heart left ventricle integrity trait |
female |
49 days-63 days |
15 |
|
8.64 |
% |
1.69 |
6.55 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49419 |
461 |
SS-Chr 2BN/Mcwi |
heart contraction pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
female |
49 days-63 days |
10 |
|
44.4 |
mmHg |
4.13 |
13.06 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
50020 |
461 |
SS-Chr 2BN/Mcwi |
serum chloride level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood chloride amount |
male |
77 days-91 days |
15 |
|
107.13 |
mmol/l |
1.29 |
5.0 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39144 |
401 |
SS-Chr 2BN/Mcwi |
blood neutrophil count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
neutrophil quantity |
male |
77 days-91 days |
15 |
|
1.37 |
x 1000 cells/ul |
0.2 |
0.76 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
43251 |
401 |
SS-Chr 2BN/Mcwi |
plasma anion gap |
control condition (for 14 days) |
PhysGen Biochemistry data |
ion homeostasis trait |
female |
77 days-91 days |
9 |
|
22.67 |
mmol/l |
0.62 |
1.87 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
43199 |
401 |
SS-Chr 2BN/Mcwi |
total white blood cell count |
control condition (for 14 days) |
PhysGen Biochemistry data |
leukocyte quantity |
female |
77 days-91 days |
9 |
|
5.68 |
x 1000 cells/ul |
0.53 |
1.59 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39953 |
401 |
SS-Chr 2BN/Mcwi |
percent change in respiration rate |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
12 |
|
115.71 |
% |
6.49 |
22.49 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54351 |
381 |
SS-Chr 2BN/Mcwi |
percent change in respiration rate |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
12 |
|
161.21 |
% |
7.47 |
25.89 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
53662 |
381 |
SS-Chr 2BN/Mcwi |
serum albumin level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood albumin amount |
female |
77 days-91 days |
9 |
|
4.12 |
g/dl |
0.07 |
0.2 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40475 |
401 |
SS-Chr 2BN/Mcwi |
serum alkaline phosphatase activity level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood alkaline phosphatase amount |
male |
77 days-91 days |
6 |
|
175.5 |
U/l |
18.0 |
44.1 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37526 |
401 |
SS-Chr 2BN/Mcwi |
total white blood cell count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
leukocyte quantity |
female |
77 days-91 days |
10 |
|
5.11 |
x 1000 cells/ul |
0.24 |
0.77 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40949 |
401 |
SS-Chr 2BN/Mcwi |
serum alanine aminotransferase activity level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood alanine transaminase amount |
male |
77 days-91 days |
6 |
|
43.33 |
U/l |
2.93 |
7.17 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37783 |
401 |
SS-Chr 2BN/Mcwi |
lung dry weight to body weight ratio |
control condition (for 14 days) |
PhysGen Lung data |
lung mass |
female |
77 days-91 days |
15 |
|
1.1 |
g/kg |
0.04 |
0.15 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59522 |
526 |
SS-Chr 2BN/Mcwi |
serum glucose level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood glucose amount |
male |
77 days-91 days |
6 |
|
161.17 |
mg/dl |
4.63 |
11.34 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41270 |
401 |
SS-Chr 2BN/Mcwi |
serum phosphate level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood phosphate amount |
male |
77 days-91 days |
6 |
|
8.25 |
mg/dl |
0.45 |
1.09 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37903 |
401 |
SS-Chr 2BN/Mcwi |
serum urea nitrogen level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood urea nitrogen amount |
female |
77 days-91 days |
9 |
|
17.78 |
mg/dl |
1.4 |
4.21 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41820 |
401 |
SS-Chr 2BN/Mcwi |
blood eosinophil count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
eosinophil quantity |
male |
77 days-91 days |
15 |
|
0.02 |
x 1000 cells/ul |
0.01 |
0.04 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41674 |
401 |
SS-Chr 2BN/Mcwi |
left ventricular diastolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
10 |
|
41.31 |
mmHg |
5.41 |
17.11 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46440 |
461 |
SS-Chr 2BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
10 |
|
209.89 |
beats/min |
13.97 |
44.19 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47605 |
461 |
SS-Chr 2BN/Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
10 |
|
1.05 |
g/mg |
0.15 |
0.48 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57399 |
522 |
SS-Chr 2BN/Mcwi |
methylene blue metabolism-surface area product without auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
12.22 |
ml/min/kg |
1.35 |
4.26 |
isolated perfused lung vascular effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57823 |
526 |
SS-Chr 2BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
15 |
|
-6.96 |
null |
0.08 |
0.32 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55684 |
522 |
SS-Chr 2BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
14 |
|
-6.94 |
null |
0.07 |
0.27 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55692 |
522 |
SS-Chr 2BN/Mcwi |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
12 |
|
0.05 |
10E-7mol/l |
0.01 |
0.04 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55760 |
522 |
SS-Chr 2BN/Mcwi |
tidal volume |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
13 |
|
0.5 |
ml |
0.05 |
0.19 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16496 |
381 |
SS-Chr 2BN/Mcwi |
FAPGG metabolism-surface area product |
controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
16 |
|
37.8 |
ml/min/kg |
2.34 |
9.36 |
isolated perfused lung vascular effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58026 |
526 |
SS-Chr 2BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
15 |
|
1.35 |
E-7mole |
0.21 |
0.83 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55953 |
522 |
SS-Chr 2BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
14 |
|
1.35 |
E-7mole |
0.2 |
0.76 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55961 |
522 |
SS-Chr 2BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
|
18.2 |
% |
1.59 |
5.03 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56298 |
522 |
SS-Chr 2BN/Mcwi |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
14 |
|
98.21 |
% |
0.74 |
2.78 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56325 |
522 |
SS-Chr 2BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
9 |
|
42.56 |
% |
4.54 |
13.63 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54845 |
522 |
SS-Chr 2BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
|
55.2 |
% |
1.96 |
6.2 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57161 |
522 |
SS-Chr 2BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
16 |
|
45.63 |
% |
2.16 |
8.65 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57187 |
522 |
SS-Chr 2BN/Mcwi |
tidal volume |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
13 |
|
0.49 |
ml |
0.05 |
0.19 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17393 |
381 |
SS-Chr 2BN/Mcwi |
tidal volume |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
12 |
|
0.54 |
ml |
0.04 |
0.13 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17397 |
381 |
SS-Chr 2BN/Mcwi |
heart weight to body weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
heart mass |
male |
49 days-63 days |
10 |
|
6.15 |
g/kg |
0.12 |
0.38 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45683 |
461 |
SS-Chr 2BN/Mcwi |
left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
9 |
|
159.65 |
mmHg |
8.57 |
25.7 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45752 |
461 |
SS-Chr 2BN/Mcwi |
arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
10 |
|
7.37 |
ml/min/g |
0.83 |
2.61 |
isolated perfused heart effluent collection |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
44741 |
461 |
SS-Chr 2BN/Mcwi |
heart contraction pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
female |
49 days-63 days |
15 |
|
55.0 |
mmHg |
4.11 |
15.93 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48056 |
461 |
SS-Chr 2BN/Mcwi |
heart contraction pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
male |
49 days-63 days |
10 |
|
65.2 |
mmHg |
3.87 |
12.25 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48060 |
461 |
SS-Chr 2BN/Mcwi |
percent change in left ventricular developed pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
14 |
post-ischemic value/pre-ischemic value x 100% |
47.8 |
% |
3.0 |
11.21 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46342 |
461 |
SS-Chr 2BN/Mcwi |
mean arterial blood pressure |
control condition |
PhysGen Respiratory data |
arterial blood pressure trait |
male |
82 days-99 days |
12 |
|
127.43 |
mmHg |
6.53 |
22.62 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15140 |
381 |
SS-Chr 2BN/Mcwi |
absolute change in blood pH |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
male |
82 days-99 days |
11 |
|
0.05 |
null |
0.01 |
0.02 |
automated blood gas analysis using a Bayer analyzer |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19830 |
381 |
SS-Chr 2BN/Mcwi |
minute ventilation |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
12 |
|
33.55 |
ml/min |
3.83 |
13.27 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20231 |
381 |
SS-Chr 2BN/Mcwi |
percent change in respiration rate |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
12 |
|
123.34 |
% |
8.05 |
27.88 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
53778 |
381 |
SS-Chr 2BN/Mcwi |
minute ventilation |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
13 |
|
72.38 |
ml/min |
7.79 |
28.07 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20784 |
381 |
SS-Chr 2BN/Mcwi |
heart rate |
control condition |
PhysGen Respiratory data |
heart pumping trait |
female |
82 days-99 days |
10 |
|
414.41 |
beats/min |
20.67 |
65.36 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20962 |
381 |
SS-Chr 2BN/Mcwi |
body weight |
control condition |
PhysGen Respiratory data |
body mass |
male |
82 days-99 days |
17 |
|
273.4 |
g |
7.0 |
29.0 |
whole body digital scale |
|
|
0 |
|
|
Moms and pups used in studies were fed Dyets |
17844 |
381 |
SS-Chr 2BN/Mcwi |
mean arterial blood pressure |
air carbon dioxide content (7 %) (for 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
female |
82 days-99 days |
9 |
|
126.07 |
mmHg |
5.22 |
15.66 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13523 |
381 |
SS-Chr 2BN/Mcwi |
respiration rate |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
13 |
|
159.75 |
breaths/min |
7.3 |
26.31 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16934 |
381 |
SS-Chr 2BN/Mcwi |
percent change in ventilation |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
13 |
%change=VE during7-9 min hypercapnia/control during standard conditions |
290.59 |
% |
20.45 |
73.73 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14221 |
381 |
SS-Chr 2BN/Mcwi |
body temperature |
control condition |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
13 |
|
37.57 |
degrees C |
0.12 |
0.45 |
digital rectal thermometry |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19092 |
381 |
SS-Chr 2BN/Mcwi |
percent change in ventilation |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
13 |
%change=VE during 2-3 min hypercapnia/control during standard conditions |
319.79 |
% |
19.68 |
70.96 |
stop flow air displacement plethysmography |
|
0 |
0 |
|
|
Moms and pups used in studies were fed Teklad |
19234 |
381 |
SS-Chr 2BN/Mcwi |
plasma creatinine level |
controlled sodium content diet (8 %) (between 19 and 22 days) |
PhysGen Renal B data |
blood creatinine amount |
male |
80 days-99 days |
9 |
|
0.35 |
mg/dl |
0.02 |
0.05 |
radioimmunoassay |
|
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52238 |
482 |
SS-Chr 2BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
male |
82 days-99 days |
12 |
|
451.08 |
beats/min |
16.57 |
57.41 |
vascular fluid filled catheter |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17551 |
381 |
SS-Chr 2BN/Mcwi |
percent change in left ventricular developed pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
44.34 |
% |
7.87 |
24.89 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46346 |
461 |
SS-Chr 2BN/Mcwi |
left ventricular systolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
15 |
|
107.85 |
mmHg |
5.48 |
21.24 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
44838 |
461 |
SS-Chr 2BN/Mcwi |
percent change in left ventricular systolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
15 |
post-ischemic value/pre-ischemic value x 100% |
79.77 |
% |
2.97 |
11.51 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
44941 |
461 |
SS-Chr 2BN/Mcwi |
plasma creatinine level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood creatinine amount |
female |
77 days-91 days |
9 |
|
0.24 |
mg/dl |
0.02 |
0.05 |
automated plasma creatinine analysis |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42714 |
401 |
SS-Chr 2BN/Mcwi |
serum total bilirubin level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood bilirubin amount |
male |
77 days-91 days |
6 |
|
0.1 |
mg/dl |
0.0 |
0.0 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42959 |
401 |
SS-Chr 2BN/Mcwi |
serum bicarbonate level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood bicarbonate amount |
female |
77 days-91 days |
9 |
|
23.33 |
mmol/l |
0.53 |
1.58 |
standard blood chemistry panel |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
43058 |
401 |
SS-Chr 2BN/Mcwi |
left ventricular systolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
9 |
|
148.18 |
mmHg |
4.5 |
13.5 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45531 |
461 |
SS-Chr 2BN/Mcwi |
heart left ventricle infarction weight to total heart left ventricle weight ratio |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) |
PhysGen Cardiac data |
heart left ventricle integrity trait |
female |
49 days-63 days |
10 |
|
1.94 |
% |
0.6 |
1.9 |
digital scale post excision weight measurement |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49721 |
461 |
SS-Chr 2BN/Mcwi |
percent change in left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
post-ischemic value/pre-ischemic value x 100% |
70.72 |
% |
3.38 |
10.69 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48783 |
461 |
SS-Chr 2BN/Mcwi |
fractional change in blood vessel diameter per unit change in intravascular pressure |
Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
blood vessel distensibility trait |
male |
77 days-91 days |
10 |
|
0.04 |
mmHg-1 |
0.0 |
0.01 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59434 |
526 |
SS-Chr 2BN/Mcwi |
minute ventilation |
control condition |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
13 |
|
24.72 |
ml/min |
1.78 |
6.41 |
stop flow air displacement plethysmography |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16170 |
381 |
SS-Chr 2BN/Mcwi |
hematocrit |
control condition (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
female |
77 days-91 days |
9 |
|
45.14 |
% |
0.86 |
2.57 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41370 |
401 |
SS-Chr 2BN/Mcwi |
hematocrit |
control condition (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
male |
77 days-91 days |
6 |
|
45.25 |
% |
0.68 |
1.66 |
automated blood cell counting method |
|
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41378 |
401 |