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Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
MAP kinase kinase activity +   
Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.

Synonyms
Exact Synonyms: ERK activator kinase activity ;   MAPK activator activity ;   MAPKK activity
Narrow Synonyms: MAP kinase kinase 4 activity ;   MAP kinase kinase 7 activity
Broad Synonyms: MEK activity
Related Synonyms: ATP:protein phosphotransferase (MAPKKK-activated) activity ;   MAP kinase or ERK kinase activity ;   MAP2K ;   MAPKK ;   MAPKK1 ;   MEK1 ;   MEK2 ;   MKK ;   MKK2 ;   MKK4 ;   MKK6 ;   MKK7 ;   STK27 ;   mitogen-activated protein kinase kinase activity
Xrefs: EC:2.7.12.2 ;   MetaCyc:2.7.12.2-RXN ;   Reactome:R-HSA-3238999 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5" ;   Reactome:R-HSA-450333 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3" ;   Reactome:R-HSA-5218804 "p38 MAPK activation by VEGFR" ;   reactome:R-HSA-1247960 "Activation of p38 MAPK" ;   reactome:R-HSA-448951 "Activation of p38 alpha/beta MAPK"
Definition Sources: ISBN:0198547684

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