JUN kinase kinase activity - Ontology Browser

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JUN kinase kinase activity (GO:0008545)
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MAP kinase kinase activity + is-a

JUN kinase kinase activity

Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase.

Synonyms
Exact Synonyms:	JNKK
Xrefs:	reactome:R-HSA-168162 "Phosphorylation of human JNKs by activated MKK4/MKK7"
Definition Sources:	GOC:bf, PMID:11057897, PMID:11790549

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