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Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
translesion synthesis +     
error-free translesion synthesis  
error-prone translesion synthesis +   
The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites.

Synonyms
Exact Synonyms: mutagenic PRR
Related Synonyms: error-prone postreplication DNA repair ;   mutagenic postreplication DNA repair
Definition Sources: GOC:elh, GOC:jl, PMID:11485998

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