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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:tyrosinemia type I pathway
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Accession:PW:0001608 term browser browse the term
Definition:Type I tyrosinemia results from defects in the fumarylacetoacetate hydrolase (FAH) enzyme that catalyzes the last step in the tyrosine degradation pathway.
Synonyms:exact_synonym: hepatorenal tyrosinemia pathway;   tyrosinemia type I disease pathway
 related_synonym: SMP:00218

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tyrosinemia type I pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh3a1 aldehyde dehydrogenase 3 family member A1 ISO SMPDB SMP:00218 NCBI chrNW_004936881:71,047...77,543
Ensembl chrNW_004936881:70,951...77,839 		JBrowse link
G Aoc1 amine oxidase copper containing 1 ISO SMPDB SMP:00218 NCBI chrNW_004936527:6,309,210...6,312,869
Ensembl chrNW_004936527:6,308,682...6,312,815 		JBrowse link
G Comt catechol-O-methyltransferase ISO SMPDB SMP:00218 NCBI chrNW_004936619:3,847,059...3,883,866
Ensembl chrNW_004936619:3,876,299...3,882,747 		JBrowse link
G Dbh dopamine beta-hydroxylase ISO SMPDB SMP:00218 NCBI chrNW_004936669:3,302,014...3,326,233
Ensembl chrNW_004936669:3,301,802...3,320,643 		JBrowse link
G Dct dopachrome tautomerase ISO SMPDB SMP:00218 NCBI chrNW_004936472:15,074,947...15,110,427
Ensembl chrNW_004936472:15,074,633...15,110,534 		JBrowse link
G Ddc dopa decarboxylase ISO SMPDB SMP:00218 NCBI chrNW_004936686:1,322,153...1,405,434
Ensembl chrNW_004936686:1,301,207...1,405,384 		JBrowse link
G Fah fumarylacetoacetate hydrolase ISO SMPDB SMP:00218 NCBI chrNW_004936471:38,140,324...38,174,472
Ensembl chrNW_004936471:38,140,273...38,174,702 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 ISO SMPDB SMP:00218 NCBI chrNW_004936636:617,376...640,424
Ensembl chrNW_004936636:617,356...640,932 		JBrowse link
G Gstz1 glutathione S-transferase zeta 1 ISO SMPDB SMP:00218 NCBI chrNW_004936488:6,141,913...6,153,591
Ensembl chrNW_004936488:6,141,317...6,154,075 		JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase ISO SMPDB SMP:00218 NCBI chrNW_004936508:8,971,516...8,987,235
Ensembl chrNW_004936508:8,971,477...8,986,404 		JBrowse link
G Hgd homogentisate 1,2-dioxygenase ISO SMPDB SMP:00218 NCBI chrNW_004936536:7,314,548...7,359,426
Ensembl chrNW_004936536:7,314,754...7,352,222 		JBrowse link
G Maoa monoamine oxidase A ISO SMPDB SMP:00218 NCBI chrNW_004936502:9,816,443...9,888,002
Ensembl chrNW_004936502:9,815,319...9,888,026 		JBrowse link
G Mif macrophage migration inhibitory factor ISO SMPDB SMP:00218 NCBI chrNW_004936619:1,207,058...1,208,010
Ensembl chrNW_004936619:1,203,746...1,208,442 		JBrowse link
G Pnmt phenylethanolamine N-methyltransferase ISO SMPDB SMP:00218 NCBI chrNW_004936490:14,858,682...14,861,614
Ensembl chrNW_004936490:14,858,603...14,865,321 		JBrowse link
G Tat tyrosine aminotransferase ISO SMPDB SMP:00218 NCBI chrNW_004936475:22,190,282...22,199,398
Ensembl chrNW_004936475:22,189,728...22,199,672 		JBrowse link
G Tyr tyrosinase ISO SMPDB SMP:00218 NCBI chrNW_004936736:421,623...519,085
Ensembl chrNW_004936736:421,598...519,253 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3944
    disease pathway 688
      nervous system disease pathway 434
        brain disease pathway 341
          inborn error of brain metabolic pathway 311
            tyrosinemia pathway 27
              tyrosinemia type I pathway 16
Path 2
Term Annotations click to browse term
  pathway 3944
    disease pathway 688
      nutritional and metabolic disease pathway 558
        metabolic disease pathway 523
          inborn error of metabolism pathway 507
            inborn error of amino acid metabolism pathway 222
              tyrosinemia pathway 27
                tyrosinemia type I pathway 16
paths to the root