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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:altered epidermal growth factor/neuregulin signaling pathway
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Accession:PW:0000775 term browser browse the term
Definition:An epidermal growth factor/neuregulin signaling pathway that deviates from what its normal course should be. Deregulation of the pathway, mostly as upregulation due to the increased expression or amplification of ligands and/or receptors, or mutations leading to such increases, has been linked to numerous forms of cancer, such as pancreatic, lung, endometrial and breast.


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altered epidermal growth factor/neuregulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor ISO RGD PMID:19506583 RGD:5490965 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor ISO RGD PMID:20519133 PMID:19506583 PMID:20951313 RGD:5133241, RGD:5490965, RGD:5133242 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:19078924 PMID:21277552 RGD:4143515, RGD:5133243 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Tgfa transforming growth factor alpha ISO RGD PMID:19506583 RGD:5490965 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2634
      growth factor signaling pathway 523
        epidermal growth factor/neuregulin signaling pathway 108
          altered epidermal growth factor/neuregulin signaling pathway 4
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