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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:amyotrophic lateral sclerosis pathway
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Accession:PW:0000016 term browser browse the term
Definition:A late onset, mostly sporadic neurodegenerative disease characterized by the loss of motor neurons in the brain stem and spinal cord. Various pathways are thought to be deregulated and contribute to the condition; among them calcium and/or zinc homeostasis, apoptosis, Cdk5 and calcineurin dependent processes, and in the case of the more rare, genetically inherited form of the disease, mutations in the cytosolic Cu, Zn superoxide dismutase (SOD1) and the subsequent changes in the processes that involve SOD1.
Synonyms:exact_synonym: ALS pathway;   amyotrophic lateral sclerosis disease pathway
 related_synonym: KEGG:05014


show annotations for term's descendants           Sort by:
amyotrophic lateral sclerosis pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Als2 alsin Rho guanine nucleotide exchange factor IEA KEGG mmu:05014 NCBI chr 1:59,201,915...59,276,390
Ensembl chr 1:59,202,085...59,276,390 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 IEA KEGG mmu:05014 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632 		JBrowse link
G Bad BCL2-associated agonist of cell death IEA KEGG mmu:05014 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Bax BCL2-associated X protein IEA KEGG mmu:05014 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 IEA KEGG mmu:05014 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 IEA KEGG mmu:05014 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bid BH3 interacting domain death agonist IEA KEGG mmu:05014 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814 		JBrowse link
G Casp1 caspase 1 IEA KEGG mmu:05014 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp12 caspase 12 IEA KEGG mmu:05014 NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032 		JBrowse link
G Casp3 caspase 3 IEA KEGG mmu:05014 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 IEA KEGG mmu:05014 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase IEA KEGG mmu:05014 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccs copper chaperone for superoxide dismutase IEA KEGG mmu:05014 NCBI chr19:4,875,394...4,889,326
Ensembl chr19:4,875,394...4,889,360 		JBrowse link
G Chp1 calcineurin-like EF hand protein 1 IEA KEGG mmu:05014 NCBI chr 2:119,378,172...119,417,505
Ensembl chr 2:119,378,178...119,417,508 		JBrowse link
G Chp2 calcineurin-like EF hand protein 2 IEA KEGG mmu:05014 NCBI chr 7:121,807,839...121,823,094
Ensembl chr 7:121,818,719...121,822,047 		JBrowse link
G Cycs cytochrome c, somatic IEA KEGG mmu:05014 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyct cytochrome c, testis IEA KEGG mmu:05014 NCBI chr 2:76,184,286...76,190,797
Ensembl chr 2:76,184,286...76,190,794 		JBrowse link
G Daxx Fas death domain-associated protein IEA KEGG mmu:05014 NCBI chr17:34,128,379...34,134,564
Ensembl chr17:34,128,388...34,134,564 		JBrowse link
G Derl1 Der1-like domain family, member 1 IEA KEGG mmu:05014 NCBI chr15:57,732,898...57,755,814
Ensembl chr15:57,732,898...57,755,844 		JBrowse link
G Gm10053 predicted gene 10053 IEA KEGG mmu:05014 NCBI chr19:24,852,990...24,854,239 JBrowse link
G Gpx1 glutathione peroxidase 1 IEA KEGG mmu:05014 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) IEA KEGG mmu:05014 NCBI chr11:56,902,342...57,221,070
Ensembl chr11:56,902,213...57,221,070 		JBrowse link
G Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) IEA KEGG mmu:05014 NCBI chr 3:80,588,757...80,711,534
Ensembl chr 3:80,588,757...80,710,142 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) IEA KEGG mmu:05014 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) IEA KEGG mmu:05014 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424 		JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) IEA KEGG mmu:05014 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509 		JBrowse link
G Grin2c glutamate receptor, ionotropic, NMDA2C (epsilon 3) IEA KEGG mmu:05014 NCBI chr11:115,139,995...115,158,123
Ensembl chr11:115,139,995...115,158,069 		JBrowse link
G Grin2d glutamate receptor, ionotropic, NMDA2D (epsilon 4) IEA KEGG mmu:05014 NCBI chr 7:45,481,307...45,520,708
Ensembl chr 7:45,481,307...45,527,802 		JBrowse link
G Map2k3 mitogen-activated protein kinase kinase 3 IEA KEGG mmu:05014 NCBI chr11:60,822,880...60,843,637
Ensembl chr11:60,822,859...60,843,637 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 IEA KEGG mmu:05014 NCBI chr11:110,289,928...110,416,348
Ensembl chr11:110,289,948...110,416,348 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 IEA KEGG mmu:05014 NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 IEA KEGG mmu:05014 NCBI chr15:89,026,685...89,033,809
Ensembl chr15:89,026,689...89,033,831 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 IEA KEGG mmu:05014 NCBI chr15:89,014,787...89,025,270
Ensembl chr15:89,014,787...89,024,906 		JBrowse link
G Mapk13 mitogen-activated protein kinase 13 IEA KEGG mmu:05014 NCBI chr17:28,988,260...28,997,678
Ensembl chr17:28,988,271...28,999,207 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 IEA KEGG mmu:05014 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Nefh neurofilament, heavy polypeptide IEA KEGG mmu:05014 NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064 		JBrowse link
G Nefl neurofilament, light polypeptide IEA KEGG mmu:05014 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544 		JBrowse link
G Nefm neurofilament, medium polypeptide IEA KEGG mmu:05014 NCBI chr14:68,356,994...68,362,453
Ensembl chr14:68,320,039...68,362,295 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal IEA KEGG mmu:05014 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform IEA KEGG mmu:05014 NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488 		JBrowse link
G Ppp3cb protein phosphatase 3, catalytic subunit, beta isoform IEA KEGG mmu:05014 NCBI chr14:20,549,432...20,596,641
Ensembl chr14:20,549,432...20,596,641 		JBrowse link
G Ppp3cc protein phosphatase 3, catalytic subunit, gamma isoform IEA KEGG mmu:05014 NCBI chr14:70,455,314...70,526,979
Ensembl chr14:70,455,314...70,526,920 		JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) IEA KEGG mmu:05014 NCBI chr11:17,109,298...17,150,380
Ensembl chr11:17,109,263...17,150,375 		JBrowse link
G Ppp3r2 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) IEA KEGG mmu:05014 NCBI chr 4:49,678,747...49,681,983
Ensembl chr 4:49,678,747...49,682,024 		JBrowse link
G Prph peripherin IEA KEGG mmu:05014 NCBI chr15:98,951,452...98,956,858
Ensembl chr15:98,953,055...98,956,859 		JBrowse link
G Prph2 peripherin 2 IEA KEGG mmu:05014 NCBI chr17:47,221,404...47,235,859
Ensembl chr17:47,221,385...47,235,859 		JBrowse link
G Rab5a RAB5A, member RAS oncogene family IEA KEGG mmu:05014 NCBI chr17:53,786,262...53,814,706
Ensembl chr17:53,786,262...53,814,708 		JBrowse link
G Rac1 Rac family small GTPase 1 IEA KEGG mmu:05014 NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791 		JBrowse link
G Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 IEA KEGG mmu:05014 NCBI chr 2:102,488,584...102,621,129
Ensembl chr 2:102,489,004...102,621,129 		JBrowse link
G Sod1 superoxide dismutase 1, soluble IDA
IEA		 KEGG
RGD		 PMID:16583367 mmu:05014, RGD:1581209 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Tnf tumor necrosis factor IEA KEGG mmu:05014 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a IEA KEGG mmu:05014 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b IEA KEGG mmu:05014 NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440 		JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 IEA KEGG mmu:05014 NCBI chr 7:19,435,238...19,449,370
Ensembl chr 7:19,435,238...19,449,363 		JBrowse link
G Tomm40l translocase of outer mitochondrial membrane 40-like IEA KEGG mmu:05014 NCBI chr 1:171,043,579...171,050,020
Ensembl chr 1:171,043,580...171,050,083 		JBrowse link
G Trp53 transformation related protein 53 IEA KEGG mmu:05014 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6070
    disease pathway 2094
      nervous system disease pathway 789
        neurodegenerative pathway 393
          amyotrophic lateral sclerosis pathway 56
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