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ONTOLOGY REPORT - ANNOTATIONS

Term:cholangiocyte proliferation
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Accession:GO:1990705 term browser browse the term
Definition:The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water.
Synonyms:exact_synonym: hepatoblast proliferation


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cholangiocyte proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lims1 LIM zinc finger domain containing 1 acts_upstream_of ISO MGI:2385067 (PMID:24058607) RGD PMID:24058607 NCBI chr20:26,309,833...26,418,511
Ensembl chr20:26,309,895...26,418,500 		JBrowse link
G Lims2 LIM zinc finger domain containing 2 acts_upstream_of ISO MGI:1195263 (PMID:24058607) RGD PMID:24058607 NCBI chr18:23,553,937...23,592,137
Ensembl chr18:23,553,937...23,592,137 		JBrowse link
G Mki67 marker of proliferation Ki-67 acts_upstream_of_or_within ISO (PMID:25446530) RGD PMID:25446530 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Notch2 notch receptor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3617328 (PMID:25446530)		 Ensembl
RGD		 PMID:25446530 GO_REF:0000107 NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088 		JBrowse link
negative regulation of cholangiocyte proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lims1 LIM zinc finger domain containing 1 acts_upstream_of_or_within ISO MGI:2385067 (PMID:24058607) RGD PMID:24058607 NCBI chr20:26,309,833...26,418,511
Ensembl chr20:26,309,895...26,418,500 		JBrowse link
G Lims2 LIM zinc finger domain containing 2 acts_upstream_of_or_within ISO MGI:1195263 (PMID:24058607) RGD PMID:24058607 NCBI chr18:23,553,937...23,592,137
Ensembl chr18:23,553,937...23,592,137 		JBrowse link
G Nppb natriuretic peptide B IDA RGD PMID:28416225 RGD:14701038 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
positive regulation of cholangiocyte proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc25a cell division cycle 25A IMP RGD PMID:22155366 RGD:14700990 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 IMP RGD PMID:28543567 RGD:14700993 NCBI chr 9:75,860,758...75,863,260
Ensembl chr 9:75,860,677...75,863,168 		JBrowse link
G Hdac6 histone deacetylase 6 IMP RGD PMID:24434010 RGD:9681551 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:24498161 RGD:10040950 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
regulation of cholangiocyte proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pkhd1 PKHD1 ciliary IPT domain containing fibrocystin/polyductin involved_in ISO (PMID:30898581) RGD PMID:30898581 NCBI chr 9:22,547,396...23,037,443
Ensembl chr 9:22,549,513...23,037,381 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19694
    cellular process 18196
      cell population proliferation 2294
        epithelial cell proliferation 573
          cholangiocyte proliferation 10
            negative regulation of cholangiocyte proliferation 3
            positive regulation of cholangiocyte proliferation 4
            regulation of cholangiocyte proliferation + 8
paths to the root