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ONTOLOGY REPORT - ANNOTATIONS

Term:oxoglutarate dehydrogenase complex
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Accession:GO:0045252 term browser browse the term
Definition:A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present.
Comment:The catalytic activities of the individual components of this complex are represented by the molecular function terms 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591' (E1), 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). The overall catalytic activity of the complex is represented by the molecular function term 'oxoglutarate dehydrogenase (NAD+) activity ; GO:0034602'.
Synonyms:exact_synonym: KGDHC;   alpha-ketoglutarate dehydrogenase complex;   dihydrolipoamide S-succinyltransferase complex
 xref: Wikipedia:Oxoglutarate_dehydrogenase_complex


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oxoglutarate dehydrogenase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd11 abhydrolase domain containing 11 part_of ISO (PMID:32792488) RGD PMID:32792488 NCBI chr12:21,682,206...21,685,331
Ensembl chr12:21,682,202...21,685,398 		JBrowse link
G Bckdha branched chain keto acid dehydrogenase E1 subunit alpha part_of ISO
ISS
IBA		 (PMID:7883996), (PMID:9582350)
GO_REF:0000024
GO_REF:0000033		 RGD
HGNC-UCL
GO_Central		 PMID:7883996 PMID:9582350 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:81,138,946...81,167,765
Ensembl chr 1:81,138,947...81,167,862 		JBrowse link
G Bckdhb branched chain keto acid dehydrogenase E1 subunit beta part_of ISO
IBA
ISS		 (PMID:2022752), (PMID:9582350)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
HGNC-UCL		 PMID:2022752 PMID:9582350 GO_REF:0000024 GO_REF:0000033 NCBI chr 8:84,845,264...85,027,812
Ensembl chr 8:84,845,264...85,027,812 		JBrowse link
G Bckdk branched chain ketoacid dehydrogenase kinase part_of IDA PMID:1377677 HGNC-UCL PMID:1377677 RGD:68712 NCBI chr 1:182,515,335...182,520,007
Ensembl chr 1:182,515,327...182,536,633 		JBrowse link
G Dld dihydrolipoamide dehydrogenase part_of IDA
ISO
IBA		 MGI:2182403 (PMID:15356189)
GO_REF:0000033
(PMID:29211711)		 RGD
GO_Central		 PMID:15356189 PMID:29211711 PMID:3571202 GO_REF:0000033, RGD:2306876 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase part_of IDA
ISO
IEA		 MGI:4367457 (PMID:22169199)
GO_REF:0000107
GO_REF:0000002
(PMID:29211711)		 RGD
Ensembl
InterPro		 PMID:22169199 PMID:29211711 PMID:9405249 PMID:3571202 GO_REF:0000002 GO_REF:0000107, RGD:1359804, RGD:2306876 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296 		JBrowse link
G Kat2a lysine acetyltransferase 2A located_in ISO (PMID:29211711) RGD PMID:29211711 NCBI chr10:85,632,216...85,640,561
Ensembl chr10:85,632,216...85,640,166 		JBrowse link
G Kgd4 alpha-ketoglutarate dehydrogenase subunit 4 part_of ISO (MGI:6810699|PMID:25165143), (MGI:7564183|PMID:36854377) RGD PMID:25165143 PMID:36854377 MGI:6810699 MGI:7564183 NCBI chr 2:31,870,549...31,878,335
Ensembl chr 2:31,870,551...31,880,730 		JBrowse link
G Ogdh oxoglutarate dehydrogenase part_of IDA
ISO
IEA
IBA		 (PMID:29211711)
GO_REF:0000107
GO_REF:0000033
(PMID:22169199)		 RGD
Ensembl
GO_Central		 PMID:22169199 PMID:29211711 PMID:3571202 GO_REF:0000033 GO_REF:0000107, RGD:2306876 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479 		JBrowse link
G Ogdhl oxoglutarate dehydrogenase L part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:7,578,343...7,604,385
Ensembl chr16:7,578,367...7,604,386 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20629
    cellular anatomical entity 20391
      cytoplasm 11695
        tricarboxylic acid cycle heteromeric enzyme complex 18
          oxoglutarate dehydrogenase complex 10
Path 2
Term Annotations click to browse term
  cellular_component 20629
    cellular anatomical entity 20391
      intracellular anatomical structure 15013
        cytoplasm 11695
          tricarboxylic acid cycle heteromeric enzyme complex 18
            oxoglutarate dehydrogenase complex 10
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