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ONTOLOGY REPORT - ANNOTATIONS

Term:RNA N6-methyladenosine methyltransferase complex
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Accession:GO:0036396 term browser browse the term
Definition:A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B).
Synonyms:exact_synonym: Mum2, Ime4, and Slz1 complex;   WMM complex
 related_synonym: METTL3-METTL14-WTAP methyltransferase complex;   MIS complex;   m(6)A writer complex;   m6A methyltransferase complex


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RNA N6-methyladenosine methyltransferase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBLL1 Cbl proto-oncogene like 1 located_in
part_of		 ISO
IEA		 (PMID:29507755) ComplexPortal
Ensembl		 PMID:29507755 GO_REF:0000107 NCBI chr 7:99,725,818...99,743,915
Ensembl chr 7:112,448,102...112,467,062 		JBrowse link
G METTL14 methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit located_in
is_active_in
part_of		 ISO
IEA		 (PMID:29507755)
(PMID:29290617)		 ComplexPortal
ARUK-UCL
TreeGrafter
UniProt
Ensembl		 PMID:29290617 PMID:29507755 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:110,879,137...110,905,131
Ensembl chr 4:121,431,026...121,458,392 		JBrowse link
G METTL3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit located_in
part_of		 ISO
IEA		 (PMID:29507755) ComplexPortal
TreeGrafter
Ensembl		 PMID:29507755 GO_REF:0000107 GO_REF:0000118 NCBI chr14:2,315,868...2,329,460
Ensembl chr14:20,392,665...20,405,906 		JBrowse link
G RBM15 RNA binding motif protein 15 part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:112,987,871...112,996,054
Ensembl chr 1:127,320,147...127,354,537 		JBrowse link
G RBM15B RNA binding motif protein 15B part_of ISO (PMID:27602518) UniProt PMID:27602518 NCBI chr 3:51,321,963...51,325,092 JBrowse link
G VIRMA vir like m6A methyltransferase associated located_in
part_of		 ISO
IEA		 (PMID:29507755)
(PMID:24981863)		 ComplexPortal
TreeGrafter
UniProt
Ensembl		 PMID:24981863 PMID:29507755 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:91,111,573...91,175,906
Ensembl chr 8:93,055,224...93,118,215 		JBrowse link
G WTAP WT1 associated protein located_in
part_of		 ISO
IEA		 (PMID:29507755) ComplexPortal
Ensembl		 PMID:29507755 GO_REF:0000107 NCBI chr 6:157,609,779...157,639,122
Ensembl chr 6:162,621,842...162,650,683 		JBrowse link
G ZC3H13 zinc finger CCCH-type containing 13 part_of
located_in		 ISO (PMID:29507755)
(MGI:6158697|PMID:29547716)		 UniProt
ComplexPortal		 PMID:29507755 PMID:29547716 MGI:6158697 NCBI chr13:26,979,940...27,077,345 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 17179
    cellular anatomical entity 16965
      intracellular anatomical structure 13627
        methyltransferase complex 103
          RNA N6-methyladenosine methyltransferase complex 8
Path 2
Term Annotations click to browse term
  cellular_component 17179
    protein-containing complex 5908
      catalytic complex 1706
        transferase complex 828
          methyltransferase complex 103
            RNA N6-methyladenosine methyltransferase complex 8
paths to the root