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ONTOLOGY REPORT - ANNOTATIONS

Term:NMDA glutamate receptor activity
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Accession:GO:0004972 term browser browse the term
Definition:An cation channel that opens in response to binding by extracellular glutmate, but only if glycine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages.
Comment:The name of this receptor comes from its selective activation by N-methyl-D-aspartate (NMDA). Note that this term represents an activity and not a gene product.
Synonyms:exact_synonym: N-methyl-D-aspartate selective glutamate receptor activity;   NMDA receptor
 xref: Wikipedia:NMDA_receptor


show annotations for term's descendants           Sort by:
NMDA glutamate receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 contributes_to
enables		 TAS
IDA
IMP
ISO
IGI		 (PMID:7679115), (PMID:7685113)
PMID:28384476
(PMID:26919761), (PMID:28105280), (PMID:28228639)
PMID:24876489
PMID:18177891
PMID:7929101
MGI:1928270|MGI:1928279|MGI:1928327|MGI:2387441|MGI:2448952|MGI:3611337|MGI:95820|MGI:95821|MGI:95822 (PMID:10963597), (PMID:12040087), (PMID:12832526), (PMID:1374164), (PMID:1377365), (PMID:1385220), (PMID:15745956), (PMID:17313573), (PMID:7531804), (PMID:8060614), (PMID:8313466)		 RGD PMID:1374164 PMID:1377365 PMID:1385220 PMID:7531804 PMID:7679115 More... RGD:727495, RGD:1642190, RGD:1642380, RGD:7241434, RGD:13432313, RGD:13432263, RGD:13432252, RGD:8553485 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A enables
contributes_to		 IDA
IMP
IEA
IBA
ISO		 PMID:28384476
PMID:23625947
GO_REF:0000117
GO_REF:0000033
MGI:1928285|MGI:1928506|MGI:95819 (PMID:11487658), (PMID:12754515), (PMID:1377365), (PMID:7816096), (PMID:8699248), (PMID:9427357), (PMID:9512392)
MGI:95819|RGD:2736 (PMID:1374164), (PMID:7929101)		 UniProt
GO_Central
RGD		 PMID:1374164 PMID:1377365 PMID:7816096 PMID:7929101 PMID:8699248 More... GO_REF:0000033 GO_REF:0000117, RGD:728651, RGD:1642190, RGD:1642380, RGD:7241434, RGD:13432313, RGD:13432339 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B enables IDA
ISO
IEA
IBA		 (PMID:26919761)
PMID:24876489
PMID:28384476
GO_REF:0000117
GO_REF:0000033
MGI:1928293|MGI:1928295|MGI:95819|MGI:95823 (PMID:10634899), (PMID:12816890), (PMID:12832518), (PMID:1377365), (PMID:7531804), (PMID:9458051)		 RGD
UniProt
GO_Central		 PMID:1377365 PMID:7531804 PMID:9458051 PMID:10634899 PMID:12816890 More... GO_REF:0000033 GO_REF:0000117, RGD:727540, RGD:1642190, RGD:13432263, RGD:13432313 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C enables
contributes_to		 IDA
ISO
IEA
IBA		 (PMID:26919761)
GO_REF:0000117
GO_REF:0000033
RGD:2736 (PMID:7929101)
MGI:1928301|MGI:1928510|MGI:95819 (PMID:1377365), (PMID:8756432), (PMID:9427357), (PMID:9512392)		 RGD
UniProt
GO_Central		 PMID:1377365 PMID:7929101 PMID:8756432 PMID:9427357 PMID:9512392 More... GO_REF:0000033 GO_REF:0000117, RGD:728651 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D enables IDA
IMP
ISO
IBA		 (PMID:26919761)
PMID:23625947
GO_REF:0000033
MGI:1928298 (PMID:12832518), (PMID:1385220)		 RGD
GO_Central		 PMID:1385220 PMID:12832518 PMID:26919761 PMID:7512349 PMID:17050728 More... GO_REF:0000033, RGD:728580, RGD:1642380, RGD:1642397, RGD:13432339 NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793 		JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A contributes_to
enables		 TAS
IDA
ISO
IEA
IBA		 PMID:17182766
(PMID:17502428)
GO_REF:0000107
GO_REF:0000033
MGI:2387963|PR:P35438 (PMID:14507892), (PMID:9620802)		 RGD
Ensembl
GO_Central		 PMID:9620802 PMID:14507892 PMID:17502428 PMID:9891978 PMID:16477151 More... GO_REF:0000033 GO_REF:0000107, RGD:632837, RGD:1642190, RGD:8553928 NCBI chr 5:64,006,847...64,206,408
Ensembl chr 5:64,009,980...64,206,085 		JBrowse link
G Grin3b glutamate ionotropic receptor NMDA type subunit 3B contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:9,730,861...9,737,183
Ensembl chr 7:9,730,862...9,737,183 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20486
    transporter activity 1237
      transmembrane transporter activity 1143
        amino acid transmembrane transporter activity 103
          glutamate-gated receptor activity 16
            NMDA glutamate receptor activity 7
Path 2
Term Annotations click to browse term
  molecular_function 20486
    transporter activity 1237
      transmembrane transporter activity 1143
        passive transmembrane transporter activity 507
          channel activity 507
            gated channel activity 331
              ligand-gated channel activity 187
                ligand-gated monoatomic ion channel activity 183
                  extracellular ligand-gated monoatomic ion channel activity 70
                    transmitter-gated monoatomic ion channel activity 60
                      glutamate-gated receptor activity 16
                        NMDA glutamate receptor activity 7
paths to the root