lactoylglutathione lyase activity - Ontology Report

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Term:	lactoylglutathione lyase activity	go back to main search page
Accession:	GO:0004462	browse the term
Definition:	Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.
Synonyms:	related_synonym:	(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity; (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming); aldoketomutase activity; glyoxalase I activity; glyoxylase I; ketone-aldehyde mutase activity; methylglyoxalase activity
	xref:	EC:4.4.1.5; KEGG_REACTION:R02530; MetaCyc:GLYOXI-RXN; RHEA:19069; reactome:R-HSA-5694071 "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH"

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Genes (1)

lactoylglutathione lyase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Glo1

glyoxalase 1

enables

IDA
ISS
ISO

GO_REF:0000024
(PMID:11489834), (PMID:20454679), (PMID:23122816), (PMID:9705294)
(MGI:5526937|PMID:18695250), (PMID:1914521), (PMID:22171037), (PMID:566476), (PMID:7323947), (PMID:7333654), (PMID:7444718), (PMID:910130)

UniProt
RGD

PMID:566476 PMID:910130 PMID:1914521 PMID:7323947 PMID:7333654 More...

GO_REF:0000024 MGI:5526937, RGD:1627641, RGD:1641958, RGD:1641959

NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649

Term paths to the root

Path 1
Term	Annotations
molecular_function	20486
catalytic activity	6038
lyase activity	211
carbon-sulfur lyase activity	13
lactoylglutathione lyase activity	1

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ONTOLOGY REPORT - ANNOTATIONS