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ONTOLOGY REPORT - ANNOTATIONS

Term:glutathione-disulfide reductase (NADPH) activity
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Accession:GO:0004362 term browser browse the term
Definition:Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.
Comment:Note that this function was formerly EC:1.6.4.2.
Synonyms:exact_synonym: glutathione reductase activity;   glutathione-disulfide reductase (NADP) activity;   glutathione-disulfide reductase activity;   glutathione-disulphide reductase activity
 related_synonym: GSH reductase activity;   GSSG reductase activity;   NADPH-GSSG reductase activity;   NADPH-glutathione reductase activity;   NADPH:oxidized-glutathione oxidoreductase activity;   glutathione S-reductase activity;   glutathione:NADP+ oxidoreductase activity;   oxidized glutathione reduction
 xref: EC:1.8.1.7;   MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN;   RHEA:11740;   reactome:R-HSA-3323079 "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+";   reactome:R-HSA-71682 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+"

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glutathione-disulfide reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsr glutathione-disulfide reductase enables ISO
IEA		 RGD
InterPro
RHEA
UniProt
Ensembl
TreeGrafter		 PMID:237922 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 RGD:1625133 NCBI chrNW_004936792:531,076...579,083
Ensembl chrNW_004936792:531,756...579,166 		JBrowse link
G Txnrd1 thioredoxin reductase 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936492:10,185,096...10,244,466
Ensembl chrNW_004936492:10,187,206...10,225,989 		JBrowse link
G Txnrd2 thioredoxin reductase 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936619:3,789,940...3,847,286
Ensembl chrNW_004936619:3,791,418...3,847,626 		JBrowse link
G Txnrd3 thioredoxin reductase 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936798:1,190,975...1,231,732
Ensembl chrNW_004936798:1,203,418...1,230,988 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17093
    antioxidant activity 76
      glutathione-disulfide reductase (NADPH) activity 4
Path 2
Term Annotations click to browse term
  molecular_function 17093
    catalytic activity 5319
      oxidoreductase activity 695
        oxidoreductase activity, acting on a sulfur group of donors 53
          disulfide oxidoreductase activity 39
            glutathione disulfide oxidoreductase activity 7
              glutathione-disulfide reductase (NADPH) activity 4
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