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ONTOLOGY REPORT - ANNOTATIONS

Term:cGAS/STING signaling pathway
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Accession:GO:0140896 term browser browse the term
Definition:The series of molecular signals initiated by the binding of a double-stranded DNA or RNA from another organism to cytosolic cyclic GMP-AMP (cGAMP) synthase (cGAS) that activates innate immune responses through production of the second messenger cGAMP, which activates the adaptor STING.


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cGAS/STING signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CGAS cyclic GMP-AMP synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:92,483,253...92,500,376
Ensembl chr 1:92,483,327...92,504,307 		JBrowse link
G DDX41 DEAD-box helicase 41 involved_in ISO (PMID:35613581) UniProt PMID:35613581 NCBI chr 2:80,433,065...80,445,484
Ensembl chr 2:80,433,190...80,438,867 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:141,359,402...141,367,222
Ensembl chr 2:141,358,993...141,367,198 		JBrowse link
negative regulation of cGAS/STING signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AARS2 alanyl-tRNA synthetase 2, mitochondrial involved_in ISO (PMID:39322678) UniProt PMID:39322678 NCBI chr 7:39,301,020...39,314,296
Ensembl chr 7:39,301,009...39,313,860 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 involved_in ISO (PMID:26440888) UniProt PMID:26440888
G AURKB aurora kinase B involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:53,410,833...53,426,165
Ensembl chr12:53,410,177...53,423,225 		JBrowse link
G BANF1 BAF nuclear assembly factor 1 involved_in ISO (PMID:32792394) UniProt PMID:32792394 NCBI chr 2:6,333,451...6,335,326
Ensembl chr 2:6,333,453...6,334,839 		JBrowse link
G CGAS cyclic GMP-AMP synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:92,483,253...92,500,376
Ensembl chr 1:92,483,327...92,504,307 		JBrowse link
G LYPLAL1 lysophospholipase like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:8,946,463...9,061,033
Ensembl chr10:8,946,487...9,062,412 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196 		JBrowse link
G PCBP2 poly(rC) binding protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:18,670,124...18,703,745
Ensembl chr 5:18,673,981...18,704,978 		JBrowse link
G PPP6C protein phosphatase 6 catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:265,872,961...265,898,146
Ensembl chr 1:265,870,477...265,898,124 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:79,687,375...79,850,146
Ensembl chr 4:79,687,375...79,846,656 		JBrowse link
G SMPDL3A sphingomyelin phosphodiesterase acid like 3A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:39,848,641...39,869,184
Ensembl chr 1:39,848,648...39,868,731 		JBrowse link
G SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:40,184,534...40,190,519
Ensembl chr 3:40,185,014...40,190,518 		JBrowse link
G TREX1 three prime repair exonuclease 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:31,177,604...31,180,764
Ensembl chr13:31,179,291...31,180,747 		JBrowse link
G ZDHHC18 zinc finger DHHC-type palmitoyltransferase 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:84,153,854...84,183,772
Ensembl chr 6:84,153,838...84,182,305 		JBrowse link
positive regulation of cGAS/STING signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTK Bruton tyrosine kinase involved_in ISO (PMID:25704810) UniProt PMID:25704810 NCBI chr  X:82,981,512...83,014,475
Ensembl chr  X:82,981,515...83,014,573 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 involved_in ISO (PMID:37832545) UniProt PMID:37832545 NCBI chr 1:58,482,046...58,548,087
Ensembl chr 1:58,481,956...58,548,057 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 involved_in ISO (PMID:36745868) UniProt PMID:36745868 NCBI chr13:207,986,094...208,007,855
Ensembl chr13:207,986,098...208,007,675 		JBrowse link
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:8,827,363...8,852,814
Ensembl chr 5:8,826,840...8,852,776 		JBrowse link
G ZDHHC9 zinc finger DHHC-type palmitoyltransferase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:106,397,139...106,436,103
Ensembl chr  X:106,401,245...106,436,014 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17654
    cellular process 17186
      signal transduction 6918
        intracellular signal transduction 2963
          intracellular receptor signaling pathway 384
            cytoplasmic pattern recognition receptor signaling pathway 179
              cGAS/STING signaling pathway 21
                negative regulation of cGAS/STING signaling pathway 14
                positive regulation of cGAS/STING signaling pathway 5
Path 2
Term Annotations click to browse term
  biological_process 17654
    response to stimulus 9992
      response to biotic stimulus 1726
        response to external biotic stimulus 1680
          response to other organism 1676
            defense response to other organism 1151
              defense response to symbiont 1036
                innate immune response 867
                  regulation of innate immune response 440
                    positive regulation of innate immune response 358
                      activation of innate immune response 295
                        innate immune response-activating signaling pathway 273
                          pattern recognition receptor signaling pathway 268
                            cytoplasmic pattern recognition receptor signaling pathway 179
                              cGAS/STING signaling pathway 21
                                negative regulation of cGAS/STING signaling pathway 14
                                positive regulation of cGAS/STING signaling pathway 5
paths to the root