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ONTOLOGY REPORT - ANNOTATIONS

Term:acylglycerol lipase activity
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Accession:GO:0047372 term browser browse the term
Definition:Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
Synonyms:related_synonym: fatty acyl monoester lipase activity;   glycerol-ester acylhydrolase activity;   monoacylglycerol hydrolase activity;   monoacylglycerol lipase activity;   monoacylglycerolipase activity;   monoglyceridase activity;   monoglyceride hydrolase activity;   monoglyceride lipase activity;   monoglyceridyllipase activity
 xref: EC:3.1.1.23;   MetaCyc:3.1.1.23-RXN;   RHEA:34019;   reactome:R-HSA-1482543 "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL";   reactome:R-HSA-163595 "2-acylglycerol + H2O -> glycerol + fatty acid";   reactome:R-HSA-192422 "Digestion of triacylglycerols by extracellular PTL:colipase";   reactome:R-HSA-192425 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)";   reactome:R-HSA-192430 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)";   reactome:R-HSA-192434 "Digestion of diacylglycerols by extracellular PTL:colipase";   reactome:R-HSA-192475 "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2";   reactome:R-HSA-426032 "DAG is metabolized by DAGL to 2-AG";   reactome:R-HSA-426043 "2-AG hydrolysis to arachidonate by MAGL";   reactome:R-HSA-5694462 "ABHD6,12 hydrolyse 3AG"


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acylglycerol lipase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd1 abhydrolase domain containing 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 5:31,107,410...31,112,439
Ensembl chr 5:31,107,410...31,112,435 		JBrowse link
G Abhd12 abhydrolase domain containing 12 enables ISO
IDA
IBA		 (MGI:5616317|PMID:18096503), (MGI:6268556|PMID:30237167), (PMID:23297193) MGI
UniProt
GO_Central		 PMID:18096503 PMID:23297193 PMID:30237167 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5616317 MGI:6268556 NCBI chr 2:150,674,413...150,746,705
Ensembl chr 2:150,674,413...150,746,661 		JBrowse link
G Abhd12b abhydrolase domain containing 12B enables IBA GO_Central GO_REF:0000033 NCBI chr12:70,200,898...70,236,870
Ensembl chr12:70,200,916...70,230,661 		JBrowse link
G Abhd15 abhydrolase domain containing 15 enables IBA GO_Central GO_REF:0000033 NCBI chr11:77,405,943...77,411,454
Ensembl chr11:77,405,947...77,429,433 		JBrowse link
G Abhd16a abhydrolase domain containing 16A enables IDA
ISO
IBA		 (MGI:5795810|PMID:25290914) BHF-UCL
MGI
GO_Central		 PMID:25290914 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5795810 NCBI chr17:35,308,210...35,321,963
Ensembl chr17:35,308,239...35,321,963 		JBrowse link
G Abhd16b abhydrolase domain containing 16B enables IBA GO_Central GO_REF:0000033 NCBI chr 2:181,134,999...181,136,773
Ensembl chr 2:181,134,999...181,136,773 		JBrowse link
G Abhd2 abhydrolase domain containing 2 enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 7:78,923,002...79,015,257
Ensembl chr 7:78,922,947...79,015,256 		JBrowse link
G Abhd3 abhydrolase domain containing 3 enables IBA GO_Central GO_REF:0000033 NCBI chr18:10,644,411...10,706,784
Ensembl chr18:10,642,092...10,706,771 		JBrowse link
G Abhd6 abhydrolase domain containing 6 enables ISO
IMP
IBA
IDA		 (PMID:20657592)
(MGI:5616317|PMID:18096503), (MGI:5700445|PMID:26491015), (PMID:20657592)		 MGI
GO_Central
UniProt		 PMID:18096503 PMID:20657592 PMID:26491015 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5616317 MGI:5700445 NCBI chr14:14,413,000...14,466,885
Ensembl chr14:14,413,010...14,466,871 		JBrowse link
G Dagla diacylglycerol lipase, alpha enables IMP (PMID:20147530) MGI PMID:20147530 NCBI chr19:10,222,629...10,282,323
Ensembl chr19:10,222,629...10,282,241 		JBrowse link
G Daglb diacylglycerol lipase, beta enables IMP (PMID:20147530) MGI PMID:20147530 NCBI chr 5:143,450,239...143,490,197
Ensembl chr 5:143,450,339...143,491,697 		JBrowse link
G Faah fatty acid amide hydrolase enables ISO
IMP		 (PMID:20657592) MGI PMID:20657592 GO_REF:0000096 MGI:4417868 NCBI chr 4:115,853,866...115,876,034
Ensembl chr 4:115,824,342...115,875,123 		JBrowse link
G Lipc lipase, hepatic enables ISO monoacylglycerol hydrolysis MGI
RGD		 PMID:6696938 GO_REF:0000096 MGI:4417868 RGD:2308779 NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508 		JBrowse link
G Lipe lipase, hormone sensitive enables IDA
ISO		 (MGI:5008527|PMID:21454566) UniProt
MGI
RGD		 PMID:15627655 PMID:21454566 GO_REF:0000096 MGI:4417868 MGI:5008527 RGD:1581872 NCBI chr 7:25,078,952...25,097,911
Ensembl chr 7:25,078,952...25,098,135 		JBrowse link
G Mgll monoglyceride lipase enables IDA
IMP
ISO
IBA		 (MGI:5616317|PMID:18096503), (MGI:6294229|PMID:20554061)
(MGI:4836780|PMID:20729846)		 UniProt
MGI
GO_Central		 PMID:18096503 PMID:20554061 PMID:20729846 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 MGI:4836780 MGI:5616317 MGI:6294229 NCBI chr 6:88,701,397...88,805,342
Ensembl chr 6:88,701,394...88,805,342 		JBrowse link
G Pnliprp2 pancreatic lipase-related protein 2 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr19:58,748,155...58,765,966
Ensembl chr19:58,748,151...58,765,966 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28831
    catalytic activity 5721
      hydrolase activity 2454
        hydrolase activity, acting on ester bonds 786
          carboxylic ester hydrolase activity 168
            acylglycerol lipase activity 16
paths to the root