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ONTOLOGY REPORT - ANNOTATIONS

Term:malate-aspartate shuttle
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Accession:GO:0043490 term browser browse the term
Definition:The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle.
Synonyms:xref: Wikipedia:Malate-aspartate_shuttle


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malate-aspartate shuttle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc1a3 solute carrier family 1 member 3 IDA RGD PMID:15242733 RGD:1642939 NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605 		JBrowse link
G Slc25a12 solute carrier family 25 member 12 involved_in
acts_upstream_of_or_within		 IMP
ISO
IEA
IBA		 (PMID:11566871)
GO_REF:0000117
GO_REF:0000033
MGI:3603462 (PMID:17213189)		 RGD
UniProt
GO_Central		 PMID:11566871 PMID:17213189 PMID:19764902 GO_REF:0000033 GO_REF:0000117, RGD:13628741 NCBI chr 3:56,097,166...56,191,841
Ensembl chr 3:56,097,269...56,192,100 		JBrowse link
G Slc25a13 solute carrier family 25 member 13 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:11566871)
GO_REF:0000117
MGI:3530352 (PMID:17213189)		 RGD
UniProt		 PMID:11566871 PMID:17213189 GO_REF:0000117 NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:34,179,224...34,361,902 		JBrowse link
G Slc25a18 solute carrier family 25 member 18 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:154,000,808...154,021,373
Ensembl chr 4:154,000,990...154,021,372 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    cellular process 18168
      transmembrane transport 1594
        mitochondrial transmembrane transport 112
          malate-aspartate shuttle 4
Path 2
Term Annotations click to browse term
  biological_process 19692
    cellular process 18168
      cellular metabolic process 9554
        generation of precursor metabolites and energy 538
          energy derivation by oxidation of organic compounds 372
            cellular respiration 266
              respiratory electron transport chain 130
                malate-aspartate shuttle 4
paths to the root