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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of type I interferon production
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Accession:GO:0032480 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
Synonyms:exact_synonym: down regulation of type I interferon production;   downregulation of type I interferon production;   negative regulation of type I IFN production
 narrow_synonym: inhibition of type I interferon production


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negative regulation of type I interferon production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 involved_in IMP (MGI:5490396|PMID:23609450) UniProt PMID:23609450 MGI:5490396 NCBI chr14:103,284,448...103,294,009
Ensembl chr14:103,284,413...103,294,009 		JBrowse link
G Atg12 autophagy related 12 involved_in IDA (MGI:3722754|PMID:17709747) ComplexPortal PMID:17709747 MGI:3722754 NCBI chr18:46,865,484...46,874,683
Ensembl chr18:46,863,211...46,874,647 		JBrowse link
G Atg5 autophagy related 5 involved_in IDA (MGI:3722754|PMID:17709747) ComplexPortal PMID:17709747 MGI:3722754 NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287 		JBrowse link
G Banf1 BAF nuclear assembly factor 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr19:5,414,661...5,416,904
Ensembl chr19:5,414,666...5,417,196 		JBrowse link
G Cul3 cullin 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:80,242,640...80,318,426
Ensembl chr 1:80,242,640...80,318,197 		JBrowse link
G Ddx56 DEAD box helicase 56 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:6,205,343...6,218,389
Ensembl chr11:6,208,919...6,217,772 		JBrowse link
G Dhx58 DExH-box helicase 58 involved_in IMP
ISO		 (MGI:5318004|PMID:21525357) UniProt
MGI		 PMID:21525357 GO_REF:0000119 MGI:4834177 MGI:5318004 NCBI chr11:100,585,710...100,595,165
Ensembl chr11:100,585,710...100,595,097 		JBrowse link
G Gbp7 guanylate binding protein 7 involved_in ISO (PMID:33408175) UniProt PMID:33408175 NCBI chr 3:142,236,097...142,255,912
Ensembl chr 3:142,236,103...142,255,910 		JBrowse link
G Gpatch3 G patch domain containing 3 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 4:133,302,056...133,311,553
Ensembl chr 4:133,302,056...133,311,554 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in IMP (MGI:5437532|PMID:22842346) UniProt PMID:22842346 MGI:5437532 NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082 		JBrowse link
G Igtp interferon gamma induced GTPase involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:58,090,382...58,098,418
Ensembl chr11:58,090,382...58,098,417 		JBrowse link
G Ilrun inflammation and lipid regulator with UBA-like and NBR1-like domains involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:27,970,206...28,039,516
Ensembl chr17:27,970,209...28,039,622 		JBrowse link
G Irgm1 immunity-related GTPase family M member 1 involved_in IMP
ISO		 (MGI:5293213|PMID:21633090), (MGI:6705154|PMID:33510463) UniProt
MGI		 PMID:21633090 PMID:33510463 GO_REF:0000119 MGI:4834177 MGI:5293213 MGI:6705154 NCBI chr11:48,756,072...48,762,247
Ensembl chr11:48,752,795...48,762,510 		JBrowse link
G Irgm2 immunity-related GTPase family M member 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:58,105,803...58,113,609
Ensembl chr11:58,090,444...58,113,608 		JBrowse link
G Kat8 K(lysine) acetyltransferase 8 involved_in IDA (MGI:6305943|PMID:30842237) UniProt PMID:30842237 MGI:6305943 NCBI chr 7:127,511,689...127,525,010
Ensembl chr 7:127,511,688...127,525,009 		JBrowse link
G Klhl22 kelch-like 22 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr16:17,577,485...17,611,246
Ensembl chr16:17,577,482...17,611,246 		JBrowse link
G Mir21a microRNA 21a involved_in ISO (PMID:23633945) BHF-UCL PMID:23633945 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984 		JBrowse link
G Nmi N-myc (and STAT) interactor acts_upstream_of_or_within IGI (PMID:23956435) MGI PMID:23956435 NCBI chr 2:51,838,517...51,863,241
Ensembl chr 2:51,838,499...51,863,506 		JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:120,270,624...120,328,526
Ensembl chr11:120,271,196...120,328,534 		JBrowse link
G Peli3 pellino 3 acts_upstream_of_or_within IMP (PMID:23042151) MGI PMID:23042151 NCBI chr19:4,979,745...4,993,155
Ensembl chr19:4,979,745...4,993,155 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:121,268,596...121,329,460
Ensembl chr 5:121,268,596...121,329,460 		JBrowse link
G Qki quaking, KH domain containing RNA binding involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:10,425,480...10,538,706
Ensembl chr17:10,421,530...10,538,783 		JBrowse link
G Rbx1 ring-box 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr15:81,350,517...81,360,570
Ensembl chr15:81,350,497...81,360,570 		JBrowse link
G Rbx1-ps ring-box 1, pseudogene involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:36,246,354...36,246,897
Ensembl chr17:36,246,516...36,246,842 		JBrowse link
G Rnf125 ring finger protein 125 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr18:21,077,672...21,120,416
Ensembl chr18:21,077,682...21,116,919 		JBrowse link
G Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:130,911,140...130,928,697
Ensembl chr 2:130,911,140...130,928,685 		JBrowse link
G Siglecl2 Siglec family like 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:43,141,468...43,155,393
Ensembl chr 7:43,141,468...43,155,364 		JBrowse link
G Traf3ip1 TRAF3 interacting protein 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:91,422,311...91,457,029
Ensembl chr 1:91,422,369...91,457,029 		JBrowse link
G Trim27 tripartite motif-containing 27 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:21,363,570...21,378,893
Ensembl chr13:21,363,615...21,378,894 		JBrowse link
G Tyrobp TYRO protein tyrosine kinase binding protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:30,113,207...30,117,007
Ensembl chr 7:30,113,185...30,117,010 		JBrowse link
G Ufd1 ubiquitin recognition factor in ER-associated degradation 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr16:18,630,486...18,654,011
Ensembl chr16:18,630,529...18,654,011 		JBrowse link
G Xaf1 XIAP associated factor 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:72,192,229...72,204,560
Ensembl chr11:72,192,455...72,204,559 		JBrowse link
negative regulation of interferon-alpha production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gbp4 guanylate binding protein 4 involved_in
acts_upstream_of_or_within		 IDA
IMP		 (PMID:22095711) UniProt
MGI		 PMID:22095711 NCBI chr 5:105,263,633...105,287,452
Ensembl chr 5:105,263,633...105,287,452 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082 		JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 involved_in IMP (MGI:5568884|PMID:24560620) UniProt PMID:24560620 MGI:5568884 NCBI chr16:3,762,871...3,796,881
Ensembl chr16:3,762,871...3,794,496 		JBrowse link
G Nmi N-myc (and STAT) interactor acts_upstream_of_or_within IMP (PMID:23956435) MGI PMID:23956435 NCBI chr 2:51,838,517...51,863,241
Ensembl chr 2:51,838,499...51,863,506 		JBrowse link
G Ptprs protein tyrosine phosphatase receptor type S involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:56,719,426...56,783,480
Ensembl chr17:56,719,426...56,783,483 		JBrowse link
negative regulation of interferon-beta production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg9a autophagy related 9A acts_upstream_of_or_within IMP (PMID:24670807) MGI PMID:24670807 NCBI chr 1:75,157,509...75,168,654
Ensembl chr 1:75,157,504...75,168,840 		JBrowse link
G Cactin cactin, spliceosome C complex subunit involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:81,156,937...81,162,085
Ensembl chr10:81,156,937...81,162,076 		JBrowse link
G Crebbp CREB binding protein involved_in IMP (MGI:2151262|PMID:11583620) CAFA PMID:11583620 MGI:2151262 NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861 		JBrowse link
G Mir26b microRNA 26b acts_upstream_of ISO (PMID:26222045) ARUK-UCL PMID:26222045 NCBI chr 1:74,433,469...74,433,553
Ensembl chr 1:74,433,469...74,433,553 		JBrowse link
G Morc3 microrchidia 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr16:93,629,009...93,672,964
Ensembl chr16:93,629,009...93,672,961 		JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 involved_in IMP (MGI:5568884|PMID:24560620) UniProt PMID:24560620 MGI:5568884 NCBI chr16:3,762,871...3,796,881
Ensembl chr16:3,762,871...3,794,496 		JBrowse link
G Nlrx1 NLR family member X1 acts_upstream_of_or_within IMP (PMID:21703540) MGI PMID:21703540 NCBI chr 9:44,164,010...44,179,896
Ensembl chr 9:44,164,014...44,179,896 		JBrowse link
G Nmi N-myc (and STAT) interactor acts_upstream_of_or_within IMP (PMID:23956435) MGI PMID:23956435 NCBI chr 2:51,838,517...51,863,241
Ensembl chr 2:51,838,499...51,863,506 		JBrowse link
G Ppm1b protein phosphatase 1B, magnesium dependent, beta isoform involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:85,264,169...85,331,420
Ensembl chr17:85,264,169...85,331,419 		JBrowse link
G Ptprs protein tyrosine phosphatase receptor type S involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:56,719,426...56,783,480
Ensembl chr17:56,719,426...56,783,483 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039 		JBrowse link
G Rel reticuloendotheliosis oncogene involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:23,686,847...23,720,969
Ensembl chr11:23,686,847...23,720,970 		JBrowse link
G Relb avian reticuloendotheliosis viral (v-rel) oncogene related B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:19,340,142...19,363,352
Ensembl chr 7:19,340,142...19,363,363 		JBrowse link
G Sirpa signal-regulatory protein alpha involved_in IMP (MGI:3760575|PMID:17954568) ARUK-UCL PMID:17954568 MGI:3760575 NCBI chr 2:129,432,962...129,474,148
Ensembl chr 2:129,434,755...129,474,148 		JBrowse link
G Traf3ip1 TRAF3 interacting protein 1 acts_upstream_of_or_within IMP (PMID:22079989) MGI PMID:22079989 NCBI chr 1:91,422,311...91,457,029
Ensembl chr 1:91,422,369...91,457,029 		JBrowse link
G Traip TRAF-interacting protein involved_in IDA (MGI:5619447|PMID:22945920) CACAO PMID:22945920 MGI:5619447 NCBI chr 9:107,828,158...107,849,469
Ensembl chr 9:107,827,335...107,849,469 		JBrowse link
G Yy1 YY1 transcription factor involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr12:108,758,841...108,786,074
Ensembl chr12:108,758,899...108,786,074 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28576
    multicellular organismal process 8916
      negative regulation of multicellular organismal process 1441
        negative regulation of cytokine production 420
          negative regulation of type I interferon production 48
            negative regulation of interferon-alpha production 5
            negative regulation of interferon-beta production 17
            suppression by virus of host type I interferon production 0
Path 2
Term Annotations click to browse term
  biological_process 28576
    biological regulation 13127
      regulation of biological process 12732
        regulation of metabolic process 6599
          regulation of biosynthetic process 5426
            regulation of cellular biosynthetic process 5336
              regulation of macromolecule biosynthetic process 5219
                regulation of gene expression 5099
                  regulation of cytokine production 977
                    negative regulation of cytokine production 420
                      negative regulation of type I interferon production 48
                        negative regulation of interferon-alpha production 5
                        negative regulation of interferon-beta production 17
                        suppression by virus of host type I interferon production 0
paths to the root