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ONTOLOGY REPORT - ANNOTATIONS

Term:sphingolipid biosynthetic process
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Accession:GO:0030148 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
Synonyms:exact_synonym: sphingolipid anabolism;   sphingolipid biosynthesis;   sphingolipid formation;   sphingolipid synthesis
 xref: MetaCyc:PWY-5129

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sphingolipid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acer1 alkaline ceramidase 1 involved_in ISO (PMID:17713573) BHF-UCL PMID:17713573 NCBI chrNW_004955495:3,247,170...3,271,417
Ensembl chrNW_004955495:3,247,083...3,271,720 		JBrowse link
G Atg7 autophagy related 7 acts_upstream_of ISO (PMID:25332431) MGI PMID:25332431 NCBI chrNW_004955429:14,076,976...14,301,034
Ensembl chrNW_004955429:14,076,960...14,304,236 		JBrowse link
G Cerkl ceramide kinase like acts_upstream_of_or_within ISO (PMID:23501591) MGI PMID:23501591 NCBI chrNW_004955403:15,620,047...15,727,957 JBrowse link
G Cers1 ceramide synthase 1 involved_in ISO (PMID:12105227) UniProt PMID:12105227 NCBI chrNW_004955524:2,788,672...2,798,068
Ensembl chrNW_004955524:2,788,653...2,796,370 		JBrowse link
G Cers2 ceramide synthase 2 acts_upstream_of_or_within ISO (PMID:15823095) MGI PMID:15823095 NCBI chrNW_004955588:338,381...342,139
Ensembl chrNW_004955588:336,083...342,599 		JBrowse link
G Cers3 ceramide synthase 3 acts_upstream_of_or_within ISO (PMID:16753040) MGI PMID:16753040 NCBI chrNW_004955416:27,461,950...27,577,145
Ensembl chrNW_004955416:27,461,335...27,536,188 		JBrowse link
G Cers4 ceramide synthase 4 acts_upstream_of_or_within ISO (PMID:15823095) MGI PMID:15823095 NCBI chrNW_004955563:1,100,410...1,105,662
Ensembl chrNW_004955563:1,100,787...1,124,258 		JBrowse link
G Cers5 ceramide synthase 5 acts_upstream_of_or_within ISO (PMID:15823095) MGI PMID:15823095 NCBI chrNW_004955547:697,089...728,573
Ensembl chrNW_004955547:697,089...726,139 		JBrowse link
G Cers6 ceramide synthase 6 acts_upstream_of_or_within ISO (PMID:15823095) MGI PMID:15823095 NCBI chrNW_004955449:5,636,678...5,920,377
Ensembl chrNW_004955449:5,642,341...5,920,573 		JBrowse link
G Degs2 delta 4-desaturase, sphingolipid 2 acts_upstream_of_or_within ISO (PMID:11937514) MGI PMID:11937514 NCBI chrNW_004955438:21,300,118...21,313,330
Ensembl chrNW_004955438:21,300,118...21,313,330 		JBrowse link
G Elovl1 ELOVL fatty acid elongase 1 involved_in ISO (PMID:20937905)
(MGI:4944052|PMID:20253178)		 UniProt PMID:20253178 PMID:20937905 MGI:4944052 NCBI chrNW_004955537:2,945,509...2,950,146
Ensembl chrNW_004955537:2,945,509...2,950,146 		JBrowse link
G Hacd1 3-hydroxyacyl-CoA dehydratase 1 involved_in ISO (PMID:18554506) UniProt PMID:18554506 NCBI chrNW_004955429:10,394,046...10,406,945
Ensembl chrNW_004955429:10,384,708...10,406,945 		JBrowse link
G Hacd2 3-hydroxyacyl-CoA dehydratase 2 involved_in ISO (PMID:18554506) UniProt PMID:18554506 NCBI chrNW_004955427:22,642,509...22,733,170
Ensembl chrNW_004955427:22,642,478...22,734,271 		JBrowse link
G Kdsr 3-ketodihydrosphingosine reductase acts_upstream_of_or_within
involved_in		 ISO (PMID:15328338)
(PMID:19141869)		 MGI
UniProt		 PMID:15328338 PMID:19141869 NCBI chrNW_004955402:47,092,779...47,130,131
Ensembl chrNW_004955402:47,092,779...47,130,132 		JBrowse link
G Sptlc1 serine palmitoyltransferase long chain base subunit 1 acts_upstream_of_or_within ISO (PMID:25332431) MGI PMID:25332431 NCBI chrNW_004955515:57,711...161,012
Ensembl chrNW_004955515:57,711...161,611 		JBrowse link
G Sptlc2 serine palmitoyltransferase long chain base subunit 2 involved_in
acts_upstream_of_or_within		 ISO (MGI:5917779|PMID:28698261)
(PMID:25332431)
(PMID:26573920)		 UniProt
MGI		 PMID:25332431 PMID:26573920 PMID:28698261 MGI:5917779 NCBI chrNW_004955438:1,385,431...1,491,534
Ensembl chrNW_004955438:1,385,431...1,491,578 		JBrowse link
G Sptssb serine palmitoyltransferase small subunit B acts_upstream_of_or_within ISO (PMID:26438849) MGI PMID:26438849 NCBI chrNW_004955448:11,756,766...11,791,418
Ensembl chrNW_004955448:11,756,766...11,790,368 		JBrowse link
ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agk acylglycerol kinase acts_upstream_of_or_within ISO (PMID:15252046) MGI PMID:15252046 NCBI chrNW_004955494:1,924,026...2,041,914
Ensembl chrNW_004955494:1,924,026...2,021,778 		JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type involved_in ISO (MGI:3789553|PMID:17403930) UniProt PMID:17403930 MGI:3789553 NCBI chrNW_004955467:8,876,186...8,887,980
Ensembl chrNW_004955467:8,876,027...8,888,033 		JBrowse link
G Aloxe3 arachidonate lipoxygenase 3 involved_in
acts_upstream_of_or_within		 ISO (MGI:5488571|PMID:22832496)
(PMID:22832496)		 UniProt
MGI		 PMID:22832496 MGI:5488571 NCBI chrNW_004955467:8,844,805...8,869,230
Ensembl chrNW_004955467:8,844,805...8,869,964 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 involved_in ISO (PMID:12764132), (PMID:12815059) UniProt PMID:12764132 PMID:12815059 NCBI chrNW_004955552:1,623,263...1,660,285
Ensembl chrNW_004955552:1,623,738...1,659,086 		JBrowse link
G Asah2 N-acylsphingosine amidohydrolase 2 involved_in ISO (PMID:17475390)
(MGI:6274955|PMID:21613224)
PMID:15123644
PMID:11278489
(PMID:11278489)		 UniProt PMID:11278489 PMID:15123644 PMID:17475390 PMID:21613224 MGI:6274955 RGD:13838793 RGD:13838803 NCBI chrNW_004955425:5,840,355...5,931,891
Ensembl chrNW_004955425:5,840,355...5,931,891 		JBrowse link
G Cers1 ceramide synthase 1 involved_in ISO (MGI:3696321|PMID:16951403), (MGI:3764760|PMID:17977534), (MGI:5755322|PMID:26620563)
(MGI:5008665|PMID:21625621), (MGI:6380950|PMID:30605666)
(PMID:12105227), (PMID:12869556), (PMID:15823095), (PMID:17548428), (PMID:18541923), (PMID:22922758), (PMID:24782409)		 UniProt PMID:12105227 PMID:12869556 PMID:15823095 PMID:16951403 PMID:17548428 More... MGI:3696321 MGI:3764760 MGI:5008665 MGI:5755322 MGI:6380950 NCBI chrNW_004955524:2,788,672...2,798,068
Ensembl chrNW_004955524:2,788,653...2,796,370 		JBrowse link
G Cers2 ceramide synthase 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:17977534), (PMID:18165233), (PMID:29632068)
(PMID:15823095)
(MGI:4421488|PMID:19801672)
(MGI:5755322|PMID:26620563)		 UniProt
MGI		 PMID:15823095 PMID:17977534 PMID:18165233 PMID:19801672 PMID:26620563 More... MGI:4421488 MGI:5755322 NCBI chrNW_004955588:338,381...342,139
Ensembl chrNW_004955588:336,083...342,599 		JBrowse link
G Cers3 ceramide synthase 3 involved_in ISO (PMID:17977534), (PMID:22038835)
(MGI:5303015|PMID:22038835)
(PMID:23754960)		 UniProt PMID:17977534 PMID:22038835 PMID:23754960 MGI:5303015 NCBI chrNW_004955416:27,461,950...27,577,145
Ensembl chrNW_004955416:27,461,335...27,536,188 		JBrowse link
G Cers4 ceramide synthase 4 involved_in
acts_upstream_of_or_within		 ISO (PMID:17977534), (PMID:29632068)
(PMID:12912983), (PMID:15823095)		 UniProt
MGI		 PMID:12912983 PMID:15823095 PMID:17977534 PMID:29632068 NCBI chrNW_004955563:1,100,410...1,105,662
Ensembl chrNW_004955563:1,100,787...1,124,258 		JBrowse link
G Cers5 ceramide synthase 5 involved_in ISO (PMID:16951403), (PMID:29632068)
(MGI:3696624|PMID:16100120), (MGI:3722529|PMID:17609214), (MGI:3764760|PMID:17977534)		 UniProt PMID:16100120 PMID:16951403 PMID:17609214 PMID:17977534 PMID:29632068 MGI:3696624 MGI:3722529 MGI:3764760 NCBI chrNW_004955547:697,089...728,573
Ensembl chrNW_004955547:697,089...726,139 		JBrowse link
G Cers6 ceramide synthase 6 involved_in
acts_upstream_of_or_within		 ISO (PMID:17609214), (PMID:17977534)
(PMID:15823095)
(MGI:5755322|PMID:26620563)
(MGI:5513027|PMID:23760501)		 UniProt
MGI		 PMID:15823095 PMID:17609214 PMID:17977534 PMID:23760501 PMID:26620563 MGI:5513027 MGI:5755322 NCBI chrNW_004955449:5,636,678...5,920,377
Ensembl chrNW_004955449:5,642,341...5,920,573 		JBrowse link
G Degs1 delta 4-desaturase, sphingolipid 1 acts_upstream_of_or_within ISO (PMID:22984457) MGI PMID:22984457 NCBI chrNW_004955520:1,139,568...1,143,149
Ensembl chrNW_004955520:1,135,563...1,143,192 		JBrowse link
G Elovl1 ELOVL fatty acid elongase 1 involved_in ISO (MGI:5532629|PMID:23689133) UniProt PMID:23689133 MGI:5532629 NCBI chrNW_004955537:2,945,509...2,950,146
Ensembl chrNW_004955537:2,945,509...2,950,146 		JBrowse link
G Fa2h fatty acid 2-hydroxylase involved_in ISO (PMID:15337768)
(MGI:6245295|PMID:22517924)		 UniProt PMID:15337768 PMID:22517924 MGI:6245295 NCBI chrNW_004955484:2,726,496...2,775,763
Ensembl chrNW_004955484:2,726,362...2,775,903 		JBrowse link
G Gba1 glucosylceramidase beta 1 involved_in ISO (PMID:19279011) BHF-UCL PMID:19279011 NCBI chrNW_004955545:1,682,097...1,689,373
Ensembl chrNW_004955545:1,682,097...1,689,376 		JBrowse link
G LOC102004294 cytochrome P450 4F22 involved_in ISO (PMID:26056268) UniProt PMID:26056268 NCBI chrNW_004955495:7,730,881...7,763,684
Ensembl chrNW_004955495:7,730,826...7,763,684 		JBrowse link
G P2rx1 purinergic receptor P2X 1 acts_upstream_of_or_within ISO (PMID:16325464) MGI PMID:16325464 NCBI chrNW_004955467:12,955,663...12,971,547
Ensembl chrNW_004955467:12,955,672...12,971,547 		JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO (PMID:16325464) MGI PMID:16325464 NCBI chrNW_004955482:7,048,674...7,087,525
Ensembl chrNW_004955482:7,048,776...7,086,926 		JBrowse link
G Pnpla1 patatin like phospholipase domain containing 1 involved_in ISO (PMID:27751867)
(MGI:5882269|PMID:27751867)		 UniProt PMID:27751867 MGI:5882269 NCBI chrNW_004955437:4,008,814...4,047,895
Ensembl chrNW_004955437:4,008,545...4,048,033 		JBrowse link
G Samd8 sterile alpha motif domain containing 8 involved_in
acts_upstream_of_or_within		 ISO (PMID:19506037)
(PMID:25667419)
(PMID:25605874)
(PMID:25605874), (PMID:25667419)		 UniProt
MGI		 PMID:19506037 PMID:25605874 PMID:25667419 NCBI chrNW_004955437:16,900,756...16,969,042
Ensembl chrNW_004955437:16,900,688...16,969,042 		JBrowse link
G Sgms1 sphingomyelin synthase 1 acts_upstream_of_or_within ISO (PMID:25605874) MGI PMID:25605874 NCBI chrNW_004955425:5,507,905...5,819,357
Ensembl chrNW_004955425:5,784,751...5,822,488 		JBrowse link
G Sgms2 sphingomyelin synthase 2 acts_upstream_of_or_within ISO (PMID:25605874) MGI PMID:25605874 NCBI chrNW_004955496:1,909,347...1,955,004
Ensembl chrNW_004955496:1,905,517...1,947,009 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 involved_in ISO (PMID:35705808)
(PMID:17303575), (PMID:18815062), (PMID:20807762), (PMID:33163980)
(MGI:82530|PMID:8706124)
(PMID:19279011), (PMID:8706124)		 RGD
UniProt
BHF-UCL		 PMID:8706124 PMID:17261082 PMID:17303575 PMID:18815062 PMID:19279011 More... MGI:82530 RGD:1601344 NCBI chrNW_004955414:22,117,929...22,121,744
Ensembl chrNW_004955414:22,117,930...22,121,744 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 ISO RGD PMID:12473648 RGD:1581395 NCBI chrNW_004955411:34,481,431...34,484,423
Ensembl chrNW_004955411:34,481,823...34,484,406 		JBrowse link
G Smpd4 sphingomyelin phosphodiesterase 4 involved_in ISO (PMID:16517606), (PMID:25180167)
(MGI:6450503|PMID:25180167)		 BHF-UCL
UniProt		 PMID:16517606 PMID:25180167 MGI:6450503 NCBI chrNW_004955442:19,184,794...19,210,999
Ensembl chrNW_004955442:19,184,794...19,210,999 		JBrowse link
G Sptlc1 serine palmitoyltransferase long chain base subunit 1 acts_upstream_of_or_within ISO (PMID:25691431)
(PMID:16216550)		 MGI PMID:16216550 PMID:25691431 NCBI chrNW_004955515:57,711...161,012
Ensembl chrNW_004955515:57,711...161,611 		JBrowse link
G Sptlc2 serine palmitoyltransferase long chain base subunit 2 acts_upstream_of_or_within ISO (PMID:25691431)
(PMID:16216550)		 MGI PMID:16216550 PMID:25691431 NCBI chrNW_004955438:1,385,431...1,491,534
Ensembl chrNW_004955438:1,385,431...1,491,578 		JBrowse link
G Sptssa serine palmitoyltransferase small subunit A acts_upstream_of_or_within ISO (PMID:25691431) MGI PMID:25691431 NCBI chrNW_004955409:26,460,208...26,460,854 JBrowse link
G Sptssb serine palmitoyltransferase small subunit B acts_upstream_of_or_within ISO (PMID:26438849) MGI PMID:26438849 NCBI chrNW_004955448:11,756,766...11,791,418
Ensembl chrNW_004955448:11,756,766...11,790,368 		JBrowse link
G Tlcd3b TLC domain containing 3B acts_upstream_of_or_within ISO (PMID:23275342) MGI PMID:23275342 NCBI chrNW_004955493:6,929,477...6,940,109
Ensembl chrNW_004955493:6,929,477...6,942,227 		JBrowse link
ceramide phosphoethanolamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Samd8 sterile alpha motif domain containing 8 acts_upstream_of_or_within ISO (PMID:25667419) MGI PMID:25667419 NCBI chrNW_004955437:16,900,756...16,969,042
Ensembl chrNW_004955437:16,900,688...16,969,042 		JBrowse link
G Sgms2 sphingomyelin synthase 2 acts_upstream_of_or_within ISO (PMID:25667419) MGI PMID:25667419 NCBI chrNW_004955496:1,909,347...1,955,004
Ensembl chrNW_004955496:1,905,517...1,947,009 		JBrowse link
galactosylceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3galt1 beta-1,3-galactosyltransferase 1 involved_in ISO (PMID:9582303) BHF-UCL PMID:9582303 NCBI chrNW_004955449:6,452,189...7,007,329
Ensembl chrNW_004955449:6,452,189...6,553,158 		JBrowse link
G B3galt2 beta-1,3-galactosyltransferase 2 involved_in ISO (PMID:9582303) BHF-UCL PMID:9582303 NCBI chrNW_004955406:30,603,238...30,610,822
Ensembl chrNW_004955406:30,603,238...30,610,822 		JBrowse link
G B4galt3 beta-1,4-galactosyltransferase 3 involved_in ISO (PMID:9405390) BHF-UCL PMID:9405390 NCBI chrNW_004955468:12,934,521...12,945,435
Ensembl chrNW_004955468:12,932,059...12,940,723 		JBrowse link
G Fa2h fatty acid 2-hydroxylase involved_in ISO PMID:17901466
(MGI:3826747|PMID:18815260)
(MGI:3696647|PMID:15658937)		 UniProt PMID:15658937 PMID:17901466 PMID:18815260 MGI:3696647 MGI:3826747 RGD:13825191 NCBI chrNW_004955484:2,726,496...2,775,763
Ensembl chrNW_004955484:2,726,362...2,775,903 		JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 acts_upstream_of_or_within ISO (PMID:10727929) MGI PMID:10727929 NCBI chrNW_004955455:4,771,378...4,794,085
Ensembl chrNW_004955455:4,771,346...4,784,142 		JBrowse link
G Ugt8 UDP glycosyltransferase 8 involved_in ISO PMID:8713090 UniProt PMID:8713090 RGD:39458006 NCBI chrNW_004955428:24,800,854...24,864,904
Ensembl chrNW_004955428:24,800,854...24,865,378 		JBrowse link
ganglioside biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3galt4 beta-1,3-galactosyltransferase 4 involved_in ISO (PMID:9582303) BHF-UCL PMID:9582303 NCBI chrNW_004955437:1,839,707...1,840,516 JBrowse link
G B4galnt1 beta-1,4-N-acetyl-galactosaminyltransferase 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:7487055), (PMID:7890749)
(PMID:10021458)
(MGI:83232|PMID:8855236)
PMID:3140234
(PMID:1601877)		 UniProt
MGI		 PMID:1601877 PMID:3140234 PMID:7487055 PMID:7890749 PMID:8855236 More... MGI:83232 RGD:21201261 NCBI chrNW_004955458:5,351,924...5,361,755
Ensembl chrNW_004955458:5,350,244...5,360,965 		JBrowse link
G St6galnac6 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 acts_upstream_of_or_within ISO (PMID:10702226) MGI PMID:10702226 NCBI chrNW_004955419:771,721...792,756
Ensembl chrNW_004955419:772,837...796,724 		JBrowse link
G St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 involved_in ISO (PMID:10766765) BHF-UCL PMID:10766765 NCBI chrNW_004955416:20,697,651...20,763,975
Ensembl chrNW_004955416:20,697,651...20,767,112 		JBrowse link
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 involved_in ISO (PMID:10766765)
(MGI:74245|PMID:7782326)		 BHF-UCL
UniProt		 PMID:7782326 PMID:10766765 MGI:74245 NCBI chrNW_004955402:41,713,969...41,732,889
Ensembl chrNW_004955402:41,713,573...41,723,749 		JBrowse link
G St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 involved_in ISO (PMID:10766765) BHF-UCL PMID:10766765 NCBI chrNW_004955418:12,590,744...12,679,677
Ensembl chrNW_004955418:12,590,536...12,679,677 		JBrowse link
G St8sia6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 involved_in ISO (MGI:2182536|PMID:11980897) BHF-UCL PMID:11980897 MGI:2182536 NCBI chrNW_004955429:10,538,660...10,660,493
Ensembl chrNW_004955429:10,538,661...10,658,008 		JBrowse link
ganglioside biosynthetic process via lactosylceramide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B4galt5 beta-1,4-galactosyltransferase 5 involved_in ISO (MGI:6196231|PMID:30114188) UniProt PMID:30114188 MGI:6196231 NCBI chrNW_004955445:8,471,684...8,559,672
Ensembl chrNW_004955445:8,534,220...8,559,672 		JBrowse link
G B4galt6 beta-1,4-galactosyltransferase 6 involved_in ISO (MGI:6196231|PMID:30114188) UniProt PMID:30114188 MGI:6196231 NCBI chrNW_004955402:18,945,013...19,024,132
Ensembl chrNW_004955402:18,942,872...19,024,132 		JBrowse link
G St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 involved_in ISO (PMID:8027041)
(MGI:65558|PMID:8144500)		 UniProt PMID:8027041 PMID:8144500 MGI:65558 NCBI chrNW_004955461:7,960,901...8,036,221
Ensembl chrNW_004955461:7,960,690...7,976,183 		JBrowse link
G St3gal2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 involved_in ISO (PMID:8920913)
(MGI:6467685|PMID:22735313)
(MGI:65558|PMID:8144500)		 UniProt PMID:8144500 PMID:8920913 PMID:22735313 MGI:6467685 MGI:65558 RGD:68307 NCBI chrNW_004955484:3,176,214...3,230,433
Ensembl chrNW_004955484:3,177,104...3,230,433 		JBrowse link
G St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 involved_in ISO (MGI:6467685|PMID:22735313) UniProt PMID:22735313 MGI:6467685 NCBI chrNW_004955537:3,258,076...3,458,742
Ensembl chrNW_004955537:3,258,076...3,458,742 		JBrowse link
globoside biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A4galt alpha 1,4-galactosyltransferase (P1PK blood group) acts_upstream_of_or_within ISO (PMID:16476743)
(PMID:22875802)		 MGI PMID:16476743 PMID:22875802 NCBI chrNW_004955413:28,018,363...28,038,359
Ensembl chrNW_004955413:28,018,451...28,019,509 		JBrowse link
globoside biosynthetic process via lactosylceramide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G St3gal2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 involved_in ISO (PMID:12716912) UniProt PMID:12716912 NCBI chrNW_004955484:3,176,214...3,230,433
Ensembl chrNW_004955484:3,177,104...3,230,433 		JBrowse link
glucosylceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fa2h fatty acid 2-hydroxylase involved_in ISO (MGI:5285470|PMID:21628453) UniProt PMID:21628453 MGI:5285470 NCBI chrNW_004955484:2,726,496...2,775,763
Ensembl chrNW_004955484:2,726,362...2,775,903 		JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase involved_in ISO (PMID:8643456)
(MGI:2180222|PMID:10430909), (MGI:3603060|PMID:16109770), (MGI:5448789|PMID:22851168), (MGI:5510915|PMID:23748427)		 UniProt PMID:8643456 PMID:10430909 PMID:16109770 PMID:22851168 PMID:23748427 MGI:2180222 MGI:3603060 MGI:5448789 MGI:5510915 NCBI chrNW_004955419:15,417,468...15,451,936
Ensembl chrNW_004955419:15,416,796...15,451,936 		JBrowse link
glycosphingolipid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A3galt2 alpha 1,3-galactosyltransferase 2 acts_upstream_of_or_within
involved_in		 ISO (PMID:22875802)
PMID:10854427
PMID:12626403		 RGD
MGI
UniProt		 PMID:10854427 PMID:12626403 PMID:22875802 RGD:1299594 RGD:632674 NCBI chrNW_004955452:11,476,485...11,489,243
Ensembl chrNW_004955452:11,474,472...11,480,849 		JBrowse link
G B4galnt1 beta-1,4-N-acetyl-galactosaminyltransferase 1 involved_in ISO PMID:1606358 UniProt PMID:1606358 RGD:21201272 NCBI chrNW_004955458:5,351,924...5,361,755
Ensembl chrNW_004955458:5,350,244...5,360,965 		JBrowse link
G B4galt6 beta-1,4-galactosyltransferase 6 ISO RGD PMID:9593693 RGD:70807 NCBI chrNW_004955402:18,945,013...19,024,132
Ensembl chrNW_004955402:18,942,872...19,024,132 		JBrowse link
G Fut4 fucosyltransferase 4 involved_in ISO (PMID:29593094) UniProt PMID:29593094 NCBI chrNW_004955605:397,721...398,470 JBrowse link
G Fut9 fucosyltransferase 9 involved_in ISO (PMID:29593094) UniProt PMID:29593094 NCBI chrNW_004955411:22,112,230...22,318,518
Ensembl chrNW_004955411:22,203,809...22,318,518 		JBrowse link
G St8sia5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 involved_in ISO PMID:1606358 UniProt PMID:1606358 RGD:21201272 NCBI chrNW_004955402:32,165,912...32,232,683
Ensembl chrNW_004955402:32,165,912...32,232,674 		JBrowse link
G Tm9sf2 transmembrane 9 superfamily member 2 involved_in ISO (PMID:30660999) UniProt PMID:30660999 NCBI chrNW_004955404:11,071,716...11,128,758
Ensembl chrNW_004955404:11,069,843...11,129,056 		JBrowse link
lactosylceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B4galt4 beta-1,4-galactosyltransferase 4 involved_in ISO (PMID:9792633) UniProt PMID:9792633 NCBI chrNW_004955427:18,964,578...18,982,090
Ensembl chrNW_004955427:18,963,396...18,985,479 		JBrowse link
G B4galt6 beta-1,4-galactosyltransferase 6 involved_in ISO (PMID:10320813) BHF-UCL PMID:10320813 NCBI chrNW_004955402:18,945,013...19,024,132
Ensembl chrNW_004955402:18,942,872...19,024,132 		JBrowse link
negative regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 acts_upstream_of_or_within ISO (PMID:25691431) MGI PMID:25691431 NCBI chrNW_004955403:9,100,516...9,113,230
Ensembl chrNW_004955403:9,100,516...9,113,223 		JBrowse link
G Ormdl2 ORMDL sphingolipid biosynthesis regulator 2 acts_upstream_of_or_within ISO (PMID:25691431) MGI PMID:25691431 NCBI chrNW_004955458:3,451,434...3,454,259
Ensembl chrNW_004955458:3,451,021...3,457,086 		JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 acts_upstream_of_or_within ISO (PMID:25691431) MGI PMID:25691431 NCBI chrNW_004955451:14,621,565...14,627,556
Ensembl chrNW_004955451:14,621,399...14,642,763 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISO (PMID:16118219)
(MGI:6294167|PMID:16118219)		 UniProt PMID:16118219 MGI:6294167 NCBI chrNW_004955506:5,902,079...5,906,639
Ensembl chrNW_004955506:5,902,345...5,904,988 		JBrowse link
negative regulation of sphingolipid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 involved_in ISO (PMID:24201375) ARUK-UCL PMID:24201375 RGD:14697729 NCBI chrNW_004955513:5,035,879...5,051,140
Ensembl chrNW_004955513:5,033,771...5,051,200 		JBrowse link
G Atg7 autophagy related 7 acts_upstream_of_or_within ISO (PMID:25332431) MGI PMID:25332431 NCBI chrNW_004955429:14,076,976...14,301,034
Ensembl chrNW_004955429:14,076,960...14,304,236 		JBrowse link
omega-hydroxyceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnpla1 patatin like phospholipase domain containing 1 involved_in ISO (PMID:28248318)
(MGI:5888934|PMID:28248300)		 UniProt PMID:28248300 PMID:28248318 MGI:5888934 NCBI chrNW_004955437:4,008,814...4,047,895
Ensembl chrNW_004955437:4,008,545...4,048,033 		JBrowse link
phytosphingosine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acer3 alkaline ceramidase 3 involved_in ISO (PMID:11356846), (PMID:20068046) UniProt PMID:11356846 PMID:20068046 NCBI chrNW_004955414:14,741,027...14,846,931
Ensembl chrNW_004955414:14,746,529...14,848,151 		JBrowse link
positive regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccn1 cellular communication network factor 1 acts_upstream_of_or_within ISO (PMID:19364818) MGI PMID:19364818 NCBI chrNW_004955423:8,416,498...8,419,029
Ensembl chrNW_004955423:8,413,725...8,419,166 		JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISO (MGI:4947032|PMID:21177474) UniProt PMID:21177474 MGI:4947032 NCBI chrNW_004955506:3,151,133...3,154,613
Ensembl chrNW_004955506:3,151,133...3,154,613 		JBrowse link
G Pla2g6 phospholipase A2 group VI ISO RGD PMID:18936091 RGD:6482750 NCBI chrNW_004955413:24,431,592...24,482,229
Ensembl chrNW_004955413:24,429,589...24,482,537 		JBrowse link
G Prkcd protein kinase C delta involved_in ISO (PMID:19279011) BHF-UCL PMID:19279011 NCBI chrNW_004955430:3,125,066...3,151,857
Ensembl chrNW_004955430:3,124,738...3,153,274 		JBrowse link
G Sirt3 sirtuin 3 involved_in ISO (MGI:5755322|PMID:26620563) UniProt PMID:26620563 MGI:5755322 NCBI chrNW_004955476:11,794,951...11,826,244
Ensembl chrNW_004955476:11,794,951...11,826,237 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 ISO RGD PMID:20096352 RGD:10041064 NCBI chrNW_004955484:8,207,686...8,298,164
Ensembl chrNW_004955484:8,272,572...8,298,144 		JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO (PMID:16118219)
(MGI:6294167|PMID:16118219)		 UniProt PMID:16118219 MGI:6294167 NCBI chrNW_004955559:1,921,479...1,929,450
Ensembl chrNW_004955559:1,917,301...1,928,493 		JBrowse link
G Znf750 zinc finger protein 750 acts_upstream_of_or_within ISO (PMID:37115925) MGI PMID:37115925 NCBI chrNW_004955506:352,616...360,802
Ensembl chrNW_004955506:352,552...363,003 		JBrowse link
regulation of ceramide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 acts_upstream_of ISO (PMID:31880535) MGI PMID:31880535 NCBI chrNW_004955403:9,100,516...9,113,230
Ensembl chrNW_004955403:9,100,516...9,113,223 		JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 acts_upstream_of ISO (PMID:31880535) MGI PMID:31880535 NCBI chrNW_004955451:14,621,565...14,627,556
Ensembl chrNW_004955451:14,621,399...14,642,763 		JBrowse link
G Prkcd protein kinase C delta involved_in ISO (PMID:17303575) UniProt PMID:17303575 NCBI chrNW_004955430:3,125,066...3,151,857
Ensembl chrNW_004955430:3,124,738...3,153,274 		JBrowse link
G Samd8 sterile alpha motif domain containing 8 involved_in ISO (PMID:19506037) UniProt PMID:19506037 NCBI chrNW_004955437:16,900,756...16,969,042
Ensembl chrNW_004955437:16,900,688...16,969,042 		JBrowse link
regulation of sphingolipid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 acts_upstream_of ISO (PMID:31880535) MGI PMID:31880535 NCBI chrNW_004955403:9,100,516...9,113,230
Ensembl chrNW_004955403:9,100,516...9,113,223 		JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 acts_upstream_of ISO (PMID:28275141)
(PMID:31880535)		 MGI PMID:28275141 PMID:31880535 NCBI chrNW_004955451:14,621,565...14,627,556
Ensembl chrNW_004955451:14,621,399...14,642,763 		JBrowse link
sphinganine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sptlc1 serine palmitoyltransferase long chain base subunit 1 acts_upstream_of_or_within ISO (PMID:19416652) MGI PMID:19416652 NCBI chrNW_004955515:57,711...161,012
Ensembl chrNW_004955515:57,711...161,611 		JBrowse link
G Sptlc2 serine palmitoyltransferase long chain base subunit 2 acts_upstream_of_or_within ISO (PMID:9363775) MGI PMID:9363775 NCBI chrNW_004955438:1,385,431...1,491,534
Ensembl chrNW_004955438:1,385,431...1,491,578 		JBrowse link
sphinganine-1-phosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sphk2 sphingosine kinase 2 involved_in ISO (PMID:10751414), (PMID:19729656)
(MGI:1860308|PMID:10751414)		 UniProt PMID:10751414 PMID:19729656 MGI:1860308 NCBI chrNW_004955559:1,921,479...1,929,450
Ensembl chrNW_004955559:1,917,301...1,928,493 		JBrowse link
sphingoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sptlc3 serine palmitoyltransferase long chain base subunit 3 acts_upstream_of_or_within ISO (PMID:19648650) MGI PMID:19648650 NCBI chrNW_004955415:22,532,193...22,686,071
Ensembl chrNW_004955415:22,531,626...22,682,564 		JBrowse link
sphingomyelin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 acts_upstream_of ISO (PMID:31880535) MGI PMID:31880535 NCBI chrNW_004955403:9,100,516...9,113,230
Ensembl chrNW_004955403:9,100,516...9,113,223 		JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 acts_upstream_of ISO (PMID:31880535) MGI PMID:31880535 NCBI chrNW_004955451:14,621,565...14,627,556
Ensembl chrNW_004955451:14,621,399...14,642,763 		JBrowse link
G Osbp oxysterol binding protein involved_in ISO (PMID:12023275) ComplexPortal PMID:12023275 NCBI chrNW_004955511:4,057,514...4,076,039
Ensembl chrNW_004955511:4,057,514...4,076,046 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase acts_upstream_of_or_within ISO (PMID:25667419) MGI PMID:25667419 NCBI chrNW_004955577:365,031...443,138
Ensembl chrNW_004955577:367,288...443,138 		JBrowse link
G Sgms1 sphingomyelin synthase 1 involved_in ISO (PMID:14685263), (PMID:14976195), (PMID:17982138)
(MGI:6221394|PMID:27892528)		 HGNC-UCL
UniProt		 PMID:14685263 PMID:14976195 PMID:17982138 PMID:27892528 MGI:6221394 NCBI chrNW_004955425:5,507,905...5,819,357
Ensembl chrNW_004955425:5,784,751...5,822,488 		JBrowse link
G Sgms2 sphingomyelin synthase 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:14685263), (PMID:17982138)
(PMID:25667419)
(MGI:6221394|PMID:27892528)		 UniProt
MGI		 PMID:14685263 PMID:17982138 PMID:25667419 PMID:27892528 MGI:6221394 NCBI chrNW_004955496:1,909,347...1,955,004
Ensembl chrNW_004955496:1,905,517...1,947,009 		JBrowse link
G Sptlc1 serine palmitoyltransferase long chain base subunit 1 involved_in
acts_upstream_of_or_within		 ISO (MGI:5749304|PMID:26301690)
(PMID:16216550)		 UniProt
MGI		 PMID:16216550 PMID:26301690 MGI:5749304 NCBI chrNW_004955515:57,711...161,012
Ensembl chrNW_004955515:57,711...161,611 		JBrowse link
G Sptlc2 serine palmitoyltransferase long chain base subunit 2 acts_upstream_of_or_within ISO (PMID:16216550) MGI PMID:16216550 NCBI chrNW_004955438:1,385,431...1,491,534
Ensembl chrNW_004955438:1,385,431...1,491,578 		JBrowse link
G Vapa VAMP associated protein A involved_in ISO (PMID:12023275) ComplexPortal PMID:12023275 NCBI chrNW_004955402:2,274,248...2,309,461
Ensembl chrNW_004955402:2,270,850...2,298,227 		JBrowse link
sphingosine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of_positive_effect ISO (PMID:26510981) ARUK-UCL PMID:26510981 NCBI chrNW_004955513:5,035,879...5,051,140
Ensembl chrNW_004955513:5,033,771...5,051,200 		JBrowse link
G Acer1 alkaline ceramidase 1 involved_in ISO (PMID:20207939)
(MGI:5800647|PMID:27126290), (MGI:6107252|PMID:29056331)
(PMID:17713573), (PMID:20628055)		 UniProt
BHF-UCL		 PMID:17713573 PMID:20207939 PMID:20628055 PMID:27126290 PMID:29056331 MGI:5800647 MGI:6107252 NCBI chrNW_004955495:3,247,170...3,271,417
Ensembl chrNW_004955495:3,247,083...3,271,720 		JBrowse link
G Acer2 alkaline ceramidase 2 involved_in ISO (PMID:20207939)
(MGI:6116621|PMID:29401619)
(PMID:16940153), (PMID:20089856), (PMID:20628055)		 UniProt PMID:16940153 PMID:20089856 PMID:20207939 PMID:20628055 PMID:29401619 MGI:6116621 NCBI chrNW_004955434:21,786,857...21,810,648
Ensembl chrNW_004955434:21,786,856...21,810,648 		JBrowse link
G Acer3 alkaline ceramidase 3 involved_in ISO (PMID:20068046)
(MGI:5749603|PMID:26474409)
(PMID:20207939), (PMID:26792856)		 UniProt PMID:20068046 PMID:20207939 PMID:26474409 PMID:26792856 MGI:5749603 NCBI chrNW_004955414:14,741,027...14,846,931
Ensembl chrNW_004955414:14,746,529...14,848,151 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 involved_in ISO (PMID:10610716)
(MGI:1267186|PMID:9653654)
(PMID:12815059)		 UniProt PMID:9653654 PMID:10610716 PMID:12815059 MGI:1267186 NCBI chrNW_004955552:1,623,263...1,660,285
Ensembl chrNW_004955552:1,623,738...1,659,086 		JBrowse link
G Asah2 N-acylsphingosine amidohydrolase 2 involved_in ISO (PMID:30154232)
PMID:15123644
(MGI:6275120|PMID:10652340)
(MGI:3608219|PMID:16126722), (MGI:3640407|PMID:16380386)
PMID:15217782
PMID:10488143		 UniProt PMID:10488143 PMID:10652340 PMID:15123644 PMID:15217782 PMID:16126722 More... MGI:3608219 MGI:3640407 MGI:6275120 RGD:13838793 RGD:13838794 RGD:13838800 NCBI chrNW_004955425:5,840,355...5,931,891
Ensembl chrNW_004955425:5,840,355...5,931,891 		JBrowse link
G Gba1 glucosylceramidase beta 1 involved_in ISO (PMID:19279011) BHF-UCL PMID:19279011 NCBI chrNW_004955545:1,682,097...1,689,373
Ensembl chrNW_004955545:1,682,097...1,689,376 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISO (PMID:23106337) UniProt PMID:23106337 NCBI chrNW_004955506:5,902,079...5,906,639
Ensembl chrNW_004955506:5,902,345...5,904,988 		JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO (PMID:23106337) UniProt PMID:23106337 NCBI chrNW_004955559:1,921,479...1,929,450
Ensembl chrNW_004955559:1,917,301...1,928,493 		JBrowse link
G Sptlc1 serine palmitoyltransferase long chain base subunit 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:19416851), (PMID:33558761)
(PMID:16216550)		 ComplexPortal
MGI		 PMID:16216550 PMID:19416851 PMID:33558761 NCBI chrNW_004955515:57,711...161,012
Ensembl chrNW_004955515:57,711...161,611 		JBrowse link
G Sptlc2 serine palmitoyltransferase long chain base subunit 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:19416851), (PMID:33558761)
(PMID:16216550)		 ComplexPortal
MGI		 PMID:16216550 PMID:19416851 PMID:33558761 NCBI chrNW_004955438:1,385,431...1,491,534
Ensembl chrNW_004955438:1,385,431...1,491,578 		JBrowse link
G Sptlc3 serine palmitoyltransferase long chain base subunit 3 involved_in ISO (PMID:19416851) ComplexPortal PMID:19416851 NCBI chrNW_004955415:22,532,193...22,686,071
Ensembl chrNW_004955415:22,531,626...22,682,564 		JBrowse link
G Sptssa serine palmitoyltransferase small subunit A involved_in ISO (PMID:19416851), (PMID:33558761) ComplexPortal PMID:19416851 PMID:33558761 NCBI chrNW_004955409:26,460,208...26,460,854 JBrowse link
G Sptssb serine palmitoyltransferase small subunit B involved_in ISO (PMID:19416851) ComplexPortal PMID:19416851 NCBI chrNW_004955448:11,756,766...11,791,418
Ensembl chrNW_004955448:11,756,766...11,790,368 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12360
    metabolic process 7487
      biosynthetic process 5310
        cellular biosynthetic process 5022
          membrane lipid biosynthetic process 108
            sphingolipid biosynthetic process 81
              ceramide biosynthetic process + 61
              ceramide phosphoethanolamine biosynthetic process 2
              glycosphingolipid biosynthetic process + 26
              negative regulation of sphingolipid biosynthetic process + 6
              positive regulation of sphingolipid biosynthetic process + 8
              regulation of sphingolipid biosynthetic process + 15
              sphinganine-1-phosphate biosynthetic process 1
              sphingoid biosynthetic process + 14
              sphingolipid biosynthesis involved in endoplasmic reticulum membrane organization 0
              sphingomyelin biosynthetic process 9
Path 2
Term Annotations click to browse term
  biological_process 12360
    metabolic process 7487
      primary metabolic process 6455
        lipid metabolic process 993
          cellular lipid metabolic process 756
            membrane lipid metabolic process 165
              membrane lipid biosynthetic process 108
                sphingolipid biosynthetic process 81
                  ceramide biosynthetic process + 61
                  ceramide phosphoethanolamine biosynthetic process 2
                  glycosphingolipid biosynthetic process + 26
                  negative regulation of sphingolipid biosynthetic process + 6
                  positive regulation of sphingolipid biosynthetic process + 8
                  regulation of sphingolipid biosynthetic process + 15
                  sphinganine-1-phosphate biosynthetic process 1
                  sphingoid biosynthetic process + 14
                  sphingolipid biosynthesis involved in endoplasmic reticulum membrane organization 0
                  sphingomyelin biosynthetic process 9
paths to the root