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ONTOLOGY REPORT - ANNOTATIONS

Term:procollagen-proline 4-dioxygenase complex
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Accession:GO:0016222 term browser browse the term
Definition:A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase.
Synonyms:broad_synonym: prolyl 4-hydroxylase complex
 related_synonym: procollagen-proline, 2-oxoglutarate-4-dioxygenase complex


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procollagen-proline 4-dioxygenase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P4HA1 prolyl 4-hydroxylase subunit alpha 1 part_of ISO (PMID:7753822) MGI PMID:7753822 NCBI chr 4:23,600,399...23,677,820
Ensembl chr 4:23,601,636...23,677,762 		JBrowse link
G P4HA2 prolyl 4-hydroxylase subunit alpha 2 part_of ISO (PMID:7753822) MGI PMID:7753822 NCBI chr11:20,514,982...20,548,261
Ensembl chr11:20,514,978...20,549,541 		JBrowse link
G P4HB prolyl 4-hydroxylase subunit beta part_of IEA Ensembl GO_REF:0000107 NCBI chr 9:427,827...436,880
Ensembl chr 9:427,830...436,064 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 18906
    protein-containing complex 6503
      endoplasmic reticulum protein-containing complex 138
        procollagen-proline 4-dioxygenase complex 3
          procollagen-proline 4-dioxygenase complex, alpha(I) type 0
          procollagen-proline 4-dioxygenase complex, alpha(II) type 0
          procollagen-proline 4-dioxygenase complex, alpha(III) type 0
Path 2
Term Annotations click to browse term
  cellular_component 18906
    cellular anatomical entity 18654
      organelle 13270
        membrane-bounded organelle 12056
          intracellular membrane-bounded organelle 11490
            endoplasmic reticulum 1734
              endoplasmic reticulum protein-containing complex 138
                procollagen-proline 4-dioxygenase complex 3
                  procollagen-proline 4-dioxygenase complex, alpha(I) type 0
                  procollagen-proline 4-dioxygenase complex, alpha(II) type 0
                  procollagen-proline 4-dioxygenase complex, alpha(III) type 0
paths to the root