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ONTOLOGY REPORT - ANNOTATIONS

Term:calcium-activated potassium channel activity
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Accession:GO:0015269 term browser browse the term
Definition:Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient.
Synonyms:xref: Reactome:R-HSA-9663752 "KCNN2 transports K+ from the cytosol to the extracellular region";   Reactome:R-HSA-9667809 "KCNMA1:KCNMB1 transports potassium ions from the cytosol to the extracellular region"


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calcium-activated potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnk18 potassium two pore domain channel subfamily K member 18 enables ISO (MGI:4839430|PMID:20006580), (PMID:14981085) RGD PMID:14981085 PMID:20006580 MGI:4839430 NCBI chr 1:258,374,671...258,388,945
Ensembl chr 1:258,374,671...258,388,945 		JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 enables IDA
IMP
ISO
TAS		 PMID:10651830
PMID:16166559
PMID:9403560
(PMID:8897882)
MGI:1334203|MGI:1913272|MGI:3053849 (PMID:10517674), (PMID:12388098), (PMID:15184377), (PMID:16306267), (PMID:17303127), (PMID:7687074)
Reactome:R-RNO-9667806
(PMID:11880513)
(PMID:7993625)
(PMID:11245614), (PMID:17706472), (PMID:18458941), (PMID:7573516), (PMID:7877450)		 RGD
Reactome		 PMID:7573516 PMID:7687074 PMID:7877450 PMID:7993625 PMID:8897882 More... Reactome:R-RNO-9667806, RGD:633136, RGD:633139, RGD:405650292, RGD:405650221 NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198 		JBrowse link
G Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 enables IBA
ISO		 GO_REF:0000033
MGI:99923 (PMID:12388098)		 GO_Central
RGD		 PMID:12388098 GO_REF:0000033 NCBI chr10:18,557,510...18,614,824
Ensembl chr10:18,557,904...18,565,798 		JBrowse link
G Kcnmb2 potassium calcium-activated channel subfamily M regulatory beta subunit 2 enables ISO
IBA
IEA		 (PMID:10692449)
GO_REF:0000033
GO_REF:0000104		 RGD
GO_Central
UniProt		 PMID:10692449 GO_REF:0000033 GO_REF:0000104 NCBI chr 2:114,670,027...114,975,374
Ensembl chr 2:114,935,976...114,975,173 		JBrowse link
G Kcnmb3 potassium calcium-activated channel subfamily M regulatory beta subunit 3 enables ISO
IBA
IEA		 (PMID:10692449)
GO_REF:0000033
GO_REF:0000104		 RGD
GO_Central
UniProt		 PMID:10692449 GO_REF:0000033 GO_REF:0000104 NCBI chr 2:115,255,788...115,270,142
Ensembl chr 2:115,253,761...115,270,142 		JBrowse link
G Kcnmb4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 enables ISS
ISO
IBA		 GO_REF:0000024
MGI:99923 (PMID:12388098)
GO_REF:0000033
(PMID:10692449)		 UniProt
RGD
GO_Central		 PMID:10692449 PMID:12388098 GO_REF:0000024 GO_REF:0000033 NCBI chr 7:52,066,145...52,119,098
Ensembl chr 7:52,066,136...52,119,278 		JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 enables ISO (PMID:17110593) RGD PMID:17110593 NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 enables ISO (PMID:18796614), (PMID:26148990)
(PMID:11724775), (PMID:12388098)		 RGD PMID:11724775 PMID:12388098 PMID:18796614 PMID:26148990 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Pkd2l1 polycystin 2 like 1, transient receptor potential cation channel enables ISO
IBA		 (PMID:10517637)
GO_REF:0000033		 RGD
GO_Central		 PMID:10517637 GO_REF:0000033 NCBI chr 1:243,032,891...243,070,031
Ensembl chr 1:243,032,913...243,070,031 		JBrowse link
intermediate conductance calcium-activated potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnn4 potassium calcium-activated channel subfamily N member 4 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:10532960 PMID:21868633 PMID:20616305 PMID:12606302 GO_REF:0000033, RGD:633066, RGD:7175507, RGD:7175508, RGD:7175510 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
large conductance calcium-activated potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 enables IDA
ISO
IEA
IBA		 MGI:3053849 (MGI:5560378|PMID:24602615), (PMID:12388098), (PMID:16873365)
(PMID:7993625)
(PMID:15703204)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:7993625 PMID:12388098 PMID:15703204 PMID:16873365 PMID:24602615 More... GO_REF:0000033 GO_REF:0000107 MGI:5560378, RGD:7205477 NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198 		JBrowse link
G Kcnu1 potassium calcium-activated channel subfamily U member 1 NOT|enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:66,141,696...66,229,493
Ensembl chr16:66,141,976...66,229,465 		JBrowse link
small conductance calcium-activated potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnn1 potassium calcium-activated channel subfamily N member 1 enables IMP
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000002
GO_REF:0000107
(PMID:12382077)		 GO_Central
InterPro
Ensembl
RGD		 PMID:12382077 PMID:19969350 PMID:14559917 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:8693687, RGD:1358336 NCBI chr16:18,574,858...18,598,585
Ensembl chr16:18,585,992...18,597,482 		JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 enables IMP
IBA
IEA
ISO
IDA		 GO_REF:0000033
GO_REF:0000002
(PMID:12382077), (PMID:19815520), (PMID:24951510)
(MGI:4366185|PMID:19815520), (MGI:5292192|PMID:19139040)
PMID:11323678		 GO_Central
InterPro
RGD		 PMID:12382077 PMID:19139040 PMID:19815520 PMID:24951510 PMID:19969350 More... GO_REF:0000002 GO_REF:0000033 MGI:4366185 MGI:5292192, RGD:8693687, RGD:8554362, RGD:1358336, RGD:7205441, RGD:7205439 NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347 		JBrowse link
G Kcnn3 potassium calcium-activated channel subfamily N member 3 enables IMP
IBA
ISO
IEA		 GO_REF:0000033
(PMID:12382077), (PMID:31155282)
GO_REF:0000107		 GO_Central
RGD
Ensembl		 PMID:12382077 PMID:31155282 PMID:14559917 PMID:17459146 PMID:19969350 More... GO_REF:0000033 GO_REF:0000107, RGD:1358336, RGD:7175515, RGD:8693687, RGD:729217, RGD:727322 NCBI chr 2:174,929,846...175,088,910
Ensembl chr 2:174,936,629...175,081,145 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20483
    transporter activity 1237
      transmembrane transporter activity 1143
        monoatomic ion transmembrane transporter activity 759
          monoatomic cation transmembrane transporter activity 637
            monoatomic cation channel activity 337
              potassium channel activity 128
                calcium-activated potassium channel activity 12
                  intermediate conductance calcium-activated potassium channel activity 1
                  large conductance calcium-activated potassium channel activity 2
                  small conductance calcium-activated potassium channel activity 4
Path 2
Term Annotations click to browse term
  molecular_function 20483
    transporter activity 1237
      transmembrane transporter activity 1143
        passive transmembrane transporter activity 507
          channel activity 507
            gated channel activity 331
              ligand-gated channel activity 187
                ligand-gated monoatomic ion channel activity 183
                  ligand-gated monoatomic cation channel activity 129
                    calcium-activated cation channel activity 26
                      calcium-activated potassium channel activity 12
                        intermediate conductance calcium-activated potassium channel activity 1
                        large conductance calcium-activated potassium channel activity 2
                        small conductance calcium-activated potassium channel activity 4
paths to the root