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ONTOLOGY REPORT - ANNOTATIONS

Term:glutathione biosynthetic process
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Accession:GO:0006750 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
Synonyms:exact_synonym: glutathione anabolism;   glutathione biosynthesis;   glutathione formation;   glutathione synthesis
 xref: MetaCyc:GLUTATHIONESYN-PWY

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glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCLC glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:10805773)
(PMID:16081425)		 RGD
MGI
TreeGrafter
UniProt
InterPro		 PMID:10805773 PMID:16081425 PMID:16183645 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 GO_REF:0000104 GO_REF:0000117 GO_REF:0000118 RGD:1582661 NCBI chr17:19,012,994...19,060,617
Ensembl chr17:19,013,026...19,060,659 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:16081425) RGD
MGI
TreeGrafter
UniProt
InterPro		 PMID:16081425 PMID:16183645 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 GO_REF:0000118 RGD:1582661 NCBI chr20:39,339,948...39,359,980
Ensembl chr20:39,339,908...39,359,430 		JBrowse link
G GSS glutathione synthetase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:81780|PMID:8660701) RGD
GOC
UniProt
InterPro		 PMID:8660701 PMID:10964706 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 MGI:81780 RGD:1599340 NCBI chr 2:39,230,629...39,258,511
Ensembl chr 2:39,230,487...39,254,648 		JBrowse link
G HAGH hydroxyacylglutathione hydrolase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:1,705,436...1,730,896
Ensembl chr 5:1,713,542...1,730,797 		JBrowse link
G LOC103223058 glutathione hydrolase light chain 2 involved_in ISO (MGI:5294309|PMID:12468440) UniProt PMID:12468440 MGI:5294309 NCBI chr19:7,353,922...7,406,392 JBrowse link
G MGST2 microsomal glutathione S-transferase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:86,629,691...86,666,912
Ensembl chr 7:86,629,642...86,666,857 		JBrowse link
G SLC1A1 solute carrier family 1 member 1 involved_in ISO (PMID:12614333) MGI PMID:12614333 NCBI chr12:74,949,560...75,041,455
Ensembl chr12:74,949,028...75,041,369 		JBrowse link
G SLC1A2 solute carrier family 1 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:29,845,512...30,012,261
Ensembl chr 1:29,847,043...29,989,975 		JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:5616326 NCBI chr14:18,135,973...18,209,471
Ensembl chr14:18,136,291...18,209,457 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 involved_in ISO (MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:5616326 NCBI chr10:62,789,647...62,825,651
Ensembl chr10:62,790,124...62,825,339 		JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC7A11 solute carrier family 7 member 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16037214) Ensembl
MGI		 PMID:16037214 GO_REF:0000107 NCBI chr 7:85,149,810...85,225,061
Ensembl chr 7:85,154,068...85,225,144 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16925
    metabolic process 10515
      amide metabolic process 430
        glutathione metabolic process 59
          glutathione biosynthetic process 11
            negative regulation of glutathione biosynthetic process 0
            positive regulation of glutathione biosynthetic process 2
            regulation of glutathione biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 16925
    metabolic process 10515
      cellular metabolic process 8755
        cellular modified amino acid metabolic process 175
          glutathione metabolic process 59
            glutathione biosynthetic process 11
              negative regulation of glutathione biosynthetic process 0
              positive regulation of glutathione biosynthetic process 2
              regulation of glutathione biosynthetic process + 3
paths to the root