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ONTOLOGY REPORT - ANNOTATIONS

Term:phosphatidylinositol 3-kinase complex
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Accession:GO:0005942 term browser browse the term
Definition:A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
Comment:For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/
Synonyms:exact_synonym: 1-phosphatidylinositol 3-kinase complex;   PI3K complex;   phosphoinositide 3-kinase complex
 narrow_synonym: PI3-kinase p85-subunit alpha- PI3-kinase p110 complex;   PIK3C3-PIK3R4 complex;   PIK3CA-PIK3R1 complex


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phosphatidylinositol 3-kinase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CISH cytokine inducible SH2 containing protein part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 3:50,531,870...50,537,319
Ensembl chr 3:51,769,194...51,774,548 		JBrowse link
G PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha part_of IEA TreeGrafter GO_REF:0000118 NCBI chr11:17,143,024...17,263,920
Ensembl chr11:16,828,966...16,949,856 		JBrowse link
G PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 1:180,024,889...180,096,287
Ensembl chr 1:184,313,233...184,384,454 		JBrowse link
G PIK3C2G phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma part_of IEA TreeGrafter GO_REF:0000118 NCBI chr12:18,258,487...18,644,464
Ensembl chr12:18,664,631...19,030,493 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha part_of ISO
IEA		 RGD
Ensembl		 PMID:12882977 GO_REF:0000107 RGD:4144086 NCBI chr 3:176,182,765...176,272,024
Ensembl chr 3:184,355,785...184,441,977 		JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta part_of ISO
IEA		 RGD
TreeGrafter		 PMID:12882977 GO_REF:0000118 RGD:4144086 NCBI chr 3:135,685,120...135,867,096
Ensembl chr 3:143,288,563...143,431,314 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 1:8,418,570...8,495,435
Ensembl chr 1:9,686,208...9,724,633 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma part_of ISO
IEA		 RGD
TreeGrafter		 PMID:12882977 GO_REF:0000118 RGD:4144086 NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 part_of ISO
IEA		 RGD
TreeGrafter		 PMID:12882977 PMID:20236230 GO_REF:0000118 RGD:4107732 RGD:4144086 NCBI chr 5:45,701,219...45,786,652
Ensembl chr 5:47,267,286...47,350,960 		JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr19:17,632,265...17,649,664
Ensembl chr19:18,611,179...18,624,177 		JBrowse link
G PIK3R3 phosphoinositide-3-kinase regulatory subunit 3 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:45,345,946...45,481,031
Ensembl chr 1:46,700,153...46,792,920 		JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 part_of ISO
IEA		 RGD
TreeGrafter		 PMID:12882977 GO_REF:0000118 RGD:4144086 NCBI chr17:42,686,483...42,773,668
Ensembl chr17:47,475,201...47,507,282 		JBrowse link
G PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr17:42,782,422...42,851,692
Ensembl chr17:47,518,629...47,585,160 		JBrowse link
G SOCS2 suppressor of cytokine signaling 2 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr12:91,115,319...91,134,191
Ensembl chr12:94,514,455...94,520,748 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr17:72,433,206...72,436,500
Ensembl chr17:77,983,389...77,984,066 		JBrowse link
G SOCS4 suppressor of cytokine signaling 4 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr14:35,614,238...35,636,531
Ensembl chr14:53,904,783...53,906,105 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr2A:46,813,589...46,878,102
Ensembl chr2A:47,804,431...47,806,041 		JBrowse link
G SOCS6 suppressor of cytokine signaling 6 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr18:63,666,761...63,710,085
Ensembl chr18:66,994,489...66,996,096 		JBrowse link
G SOCS7 suppressor of cytokine signaling 7 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr17:18,867,241...18,921,792
Ensembl chr17:19,193,860...19,236,427 		JBrowse link
phosphatidylinositol 3-kinase complex, class IA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha located_in
part_of		 ISO
IEA		 (PMID:19805105) ComplexPortal
TreeGrafter
Ensembl		 PMID:19805105 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:176,182,765...176,272,024
Ensembl chr 3:184,355,785...184,441,977 		JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta located_in
part_of		 ISO
IEA		 (PMID:20713702), (PMID:22402981) ComplexPortal
Ensembl		 PMID:20713702 PMID:22402981 GO_REF:0000107 NCBI chr 3:135,685,120...135,867,096
Ensembl chr 3:143,288,563...143,431,314 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta located_in
part_of		 ISO
IEA		 (PMID:28108251) ComplexPortal
Ensembl		 PMID:28108251 GO_REF:0000107 NCBI chr 1:8,418,570...8,495,435
Ensembl chr 1:9,686,208...9,724,633 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma located_in ISO (PMID:10358071) ComplexPortal PMID:10358071 NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 located_in
part_of		 ISO
IEA		 (PMID:19805105), (PMID:20713702), (PMID:28108251) ComplexPortal
Ensembl		 PMID:19805105 PMID:20713702 PMID:28108251 GO_REF:0000107 NCBI chr 5:45,701,219...45,786,652
Ensembl chr 5:47,267,286...47,350,960 		JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 located_in
part_of		 ISO
IEA		 (PMID:22402981) ComplexPortal
Ensembl		 PMID:22402981 GO_REF:0000107 NCBI chr19:17,632,265...17,649,664
Ensembl chr19:18,611,179...18,624,177 		JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 located_in ISO (PMID:10358071) ComplexPortal PMID:10358071 NCBI chr17:42,686,483...42,773,668
Ensembl chr17:47,475,201...47,507,282 		JBrowse link
G PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 located_in ISO (PMID:10358071) ComplexPortal PMID:10358071 NCBI chr17:42,782,422...42,851,692
Ensembl chr17:47,518,629...47,585,160 		JBrowse link
phosphatidylinositol 3-kinase complex, class IB term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 3:176,182,765...176,272,024
Ensembl chr 3:184,355,785...184,441,977 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma part_of IEA Ensembl GO_REF:0000107 NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614 		JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 part_of IEA InterPro GO_REF:0000002 NCBI chr17:42,686,483...42,773,668
Ensembl chr17:47,475,201...47,507,282 		JBrowse link
G PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 part_of IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr17:42,782,422...42,851,692
Ensembl chr17:47,518,629...47,585,160 		JBrowse link
phosphatidylinositol 3-kinase complex, class III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG14 autophagy related 14 located_in
part_of		 ISO
IEA		 (PMID:25490155) ComplexPortal
Ensembl
TreeGrafter		 PMID:25490155 GO_REF:0000107 GO_REF:0000118 NCBI chr14:35,953,228...35,998,650
Ensembl chr14:54,226,720...54,272,018 		JBrowse link
G BECN1 beclin 1 located_in
part_of		 ISO
IEA		 (PMID:25490155) ComplexPortal
Ensembl		 PMID:25490155 GO_REF:0000107 NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286 		JBrowse link
G NRBF2 nuclear receptor binding factor 2 part_of
located_in		 ISO (MGI:5634877|PMID:24849286)
(PMID:24785657)		 UniProt PMID:24785657 PMID:24849286 MGI:5634877 NCBI chr10:59,640,101...59,662,071
Ensembl chr10:61,965,758...61,987,435 		JBrowse link
G PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 located_in
part_of		 ISO
IEA		 (PMID:25490155) ComplexPortal
Ensembl		 PMID:25490155 GO_REF:0000107 NCBI chr18:35,203,896...35,336,512
Ensembl chr18:38,754,789...38,882,037 		JBrowse link
G PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 located_in
part_of		 ISO
IEA		 (PMID:25490155) ComplexPortal
Ensembl		 PMID:25490155 GO_REF:0000107 NCBI chr 3:127,743,873...127,834,512
Ensembl chr 3:135,089,584...135,157,193 		JBrowse link
G UVRAG UV radiation resistance associated located_in
part_of		 ISO
IEA		 (PMID:25490155) ComplexPortal
Ensembl		 PMID:25490155 GO_REF:0000107 NCBI chr11:70,870,341...71,197,559
Ensembl chr11:74,172,919...74,496,046 		JBrowse link
phosphatidylinositol 3-kinase complex, class III, type I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BECN1 beclin 1 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286 		JBrowse link
G BECN2 beclin 2 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 1:217,520,628...217,522,177
Ensembl chr 1:222,499,853...222,501,148 		JBrowse link
G PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr18:35,203,896...35,336,512
Ensembl chr18:38,754,789...38,882,037 		JBrowse link
G PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 3:127,743,873...127,834,512
Ensembl chr 3:135,089,584...135,157,193 		JBrowse link
phosphatidylinositol 3-kinase complex, class III, type II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BECN1 beclin 1 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286 		JBrowse link
G BECN2 beclin 2 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 1:217,520,628...217,522,177
Ensembl chr 1:222,499,853...222,501,148 		JBrowse link
G PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr18:35,203,896...35,336,512
Ensembl chr18:38,754,789...38,882,037 		JBrowse link
G PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 3:127,743,873...127,834,512
Ensembl chr 3:135,089,584...135,157,193 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 17180
    cellular anatomical entity 16965
      extrinsic component of membrane 228
        phosphatidylinositol 3-kinase complex 26
          phosphatidylinositol 3-kinase complex, class I + 8
          phosphatidylinositol 3-kinase complex, class II 0
          phosphatidylinositol 3-kinase complex, class III + 7
Path 2
Term Annotations click to browse term
  cellular_component 17180
    protein-containing complex 5905
      catalytic complex 1707
        transferase complex 834
          transferase complex, transferring phosphorus-containing groups 281
            phosphatidylinositol 3-kinase complex 26
              phosphatidylinositol 3-kinase complex, class I + 8
              phosphatidylinositol 3-kinase complex, class II 0
              phosphatidylinositol 3-kinase complex, class III + 7
paths to the root