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ONTOLOGY REPORT - ANNOTATIONS

Term:insulin receptor complex
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Accession:GO:0005899 term browser browse the term
Definition:A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.
Synonyms:only_in_taxon: NCBITaxon:6072 ! Eumetazoa


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insulin receptor complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1r insulin-like growth factor 1 receptor part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Insr insulin receptor part_of ISO
IBA		 (PMID:15069075), (PMID:1898103), (PMID:19406747)
GO_REF:0000033		 RGD
GO_Central		 PMID:1898103 PMID:15069075 PMID:19406747 GO_REF:0000033 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Insrr insulin receptor-related receptor part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:173,255,335...173,274,800
Ensembl chr 2:173,255,414...173,274,800 		JBrowse link
G Irs1 insulin receptor substrate 1 part_of IMP PMID:15069075 BHF-UCL PMID:15069075 RGD:8554248 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 IDA RGD PMID:14525909 RGD:11038810 NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20624
    protein-containing complex 6599
      receptor complex 444
        plasma membrane signaling receptor complex 224
          insulin receptor complex 5
Path 2
Term Annotations click to browse term
  cellular_component 20624
    cellular anatomical entity 20384
      cell periphery 6880
        plasma membrane 6401
          plasma membrane protein complex 625
            plasma membrane signaling receptor complex 224
              insulin receptor complex 5
paths to the root