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ONTOLOGY REPORT - ANNOTATIONS

Term:metalloendopeptidase activity
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Accession:GO:0004222 term browser browse the term
Definition:Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Synonyms:narrow_synonym: metalloendoprotease activity;   metalloendoproteinase activity
 xref: EC:3.4.24;   Reactome:R-HSA-181567 "botC LC cleaves target cell STX1";   Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25";   Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2";   Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25";   Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1";   Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1";   Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25";   Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14, TMPRSS6";   Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)";   Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2";   Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2";   Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2";   Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2";   Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1";   Reactome:R-HSA-8874122 "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)";   Reactome:R-HSA-9624272 "MMPs cleave HB-EGF";   Reactome:R-HSA-9822532 "ADAMTS13 cleaves VWF multimer";   Reactome:R-HSA-9824402 "ADAMTS13 variant does not cleave VWF multimer";   Reactome:R-HSA-9840408 "OMA1 cleaves DELE1";   Reactome:R-HSA-9840532 "OMA1 self-cleaves";   Reactome:R-HSA-9840564 "OMA1 hydrolyzes YME1L1";   Reactome:R-HSA-9844241 "ADAMTS13 cleaves VWF variant multimer";   reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR";   reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17";   reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors";   reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors";   reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13";   reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2";   reactome:R-HSA-1458433 "Collagen type I degradation by MMP14";   reactome:R-HSA-1474196 "Collagen type II degradation by MMP14";   reactome:R-HSA-1474210 "Collagen type III degradation by MMP14";   reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13";   reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11";   reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13";   reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3";   reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12";   reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2";   reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10";   reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1";   reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9";   reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13";   reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs";   reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2";   reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF";   reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides";   reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides";   reactome:R-HSA-2022141 "Prolysyl oxidase activation";   reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12";   reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9";   reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF";   reactome:R-HSA-2473584 "Collagen type III degradation by MMP15";   reactome:R-HSA-2473594 "Collagen type II degradation by MMP15";   reactome:R-HSA-2473596 "Collagen type I degradation by MMP15";   reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13";   reactome:R-HSA-2485111 "Collagen type III degradation by MMP10";   reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13";   reactome:R-HSA-2514790 "Elastin degradation by MMP14";   reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14";   reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14";   reactome:R-HSA-2533944 "Fibronectin degradation by MMP10";   reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15";   reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7";   reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15";   reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7";   reactome:R-HSA-2537499 "Gelatin degradation by MMP19";   reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1";   reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5";   reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19";   reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14";   reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13";   reactome:R-HSA-3791319 "NID1 degradation by MMP19";   reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS";   reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4";   reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS";   reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7";   reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14";   reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7";   reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)";   reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15";   reactome:R-HSA-5333671 "CLCAs self cleave";   reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding";   reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3";   reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)";   reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1";   reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2";   reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3";   reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1";   reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4";   reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3";   reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)";   reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)";   reactome:R-HSA-8940554 "MMP2 cleaves OPTC";   reactome:R-HSA-8940561 "MMP7 cleaves OPTC";   reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)";   reactome:R-HSA-8940959 "Neurolysin degrades neurotensin";   reactome:R-HSA-8942302 "MMP13 cleaves OPTC";   reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3";   reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)";   reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU";   reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1"

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metalloendopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme enables IEA Ensembl GO_REF:0000107 Ensembl chr16:57,700,977...57,806,815 JBrowse link
G ADAM10 ADAM metallopeptidase domain 10 enables ISO
IEA		 RGD
InterPro
Ensembl		 PMID:10423016 GO_REF:0000002 GO_REF:0000107 RGD:631800 NCBI chr26:24,768,827...24,921,169
Ensembl chr26:24,768,915...24,919,009 		JBrowse link
G ADAM11 ADAM metallopeptidase domain 11 enables IEA InterPro GO_REF:0000002 NCBI chr16:61,621,707...61,644,813
Ensembl chr16:61,621,673...61,644,723 		JBrowse link
G ADAM12 ADAM metallopeptidase domain 12 enables IEA InterPro GO_REF:0000002 NCBI chr 9:118,641,551...119,014,280
Ensembl chr 9:118,646,539...118,749,351 		JBrowse link
G ADAM15 ADAM metallopeptidase domain 15 enables IEA InterPro GO_REF:0000002 NCBI chr20:8,767,836...8,779,399
Ensembl chr20:8,768,112...8,779,311 		JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr14:98,092,093...98,157,657
Ensembl chr14:98,092,044...98,157,217 		JBrowse link
G ADAM18 ADAM metallopeptidase domain 18 enables IEA InterPro GO_REF:0000002 NCBI chr 8:37,600,595...37,743,772
Ensembl chr 8:37,601,156...37,743,650 		JBrowse link
G ADAM19 ADAM metallopeptidase domain 19 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr23:59,867,949...59,966,873
Ensembl chr23:59,867,596...59,966,802 		JBrowse link
G ADAM2 ADAM metallopeptidase domain 2 enables IEA InterPro GO_REF:0000002 Ensembl chr 8:37,759,402...37,809,910 JBrowse link
G ADAM22 ADAM metallopeptidase domain 22 enables IEA InterPro GO_REF:0000002 NCBI chr21:60,753,344...60,999,283
Ensembl chr21:60,759,980...60,998,600 		JBrowse link
G ADAM23 ADAM metallopeptidase domain 23 enables IEA InterPro GO_REF:0000002 NCBI chr10:92,218,999...92,390,905
Ensembl chr10:92,219,253...92,391,091 		JBrowse link
G ADAM28 ADAM metallopeptidase domain 28 enables IEA InterPro GO_REF:0000002 NCBI chr 8:22,424,260...22,483,878
Ensembl chr 8:22,430,579...22,488,257 		JBrowse link
G ADAM29 ADAM metallopeptidase domain 29 enables IEA InterPro GO_REF:0000002 NCBI chr 7:121,006,675...121,053,292 JBrowse link
G ADAM30 ADAM metallopeptidase domain 30 enables IEA InterPro GO_REF:0000002 NCBI chr20:13,887,509...13,890,543
Ensembl chr20:13,887,666...13,890,095 		JBrowse link
G ADAM33 ADAM metallopeptidase domain 33 enables IEA InterPro GO_REF:0000002 NCBI chr 2:34,352,514...34,366,694
Ensembl chr 2:34,353,505...34,366,559 		JBrowse link
G ADAM7 ADAM metallopeptidase domain 7 enables IEA InterPro GO_REF:0000002 NCBI chr 8:22,573,508...22,631,657
Ensembl chr 8:22,574,681...22,633,039 		JBrowse link
G ADAM8 ADAM metallopeptidase domain 8 enables IEA InterPro GO_REF:0000002 NCBI chr26:53,114,184...53,129,650
Ensembl chr26:53,114,924...53,126,900 		JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 8:37,017,827...37,131,462
Ensembl chr 8:37,017,545...37,131,615 		JBrowse link
G ADAMDEC1 ADAM like decysin 1 enables IEA InterPro GO_REF:0000002 NCBI chr 8:22,516,511...22,537,706
Ensembl chr 8:22,516,639...22,537,731 		JBrowse link
G ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:65,376,288...65,385,398
Ensembl chr 2:65,376,310...65,385,918 		JBrowse link
G ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif 10 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 6:7,923,429...7,954,733
Ensembl chr 6:7,924,076...7,949,685 		JBrowse link
G ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif 12 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:32,757,699...33,129,116
Ensembl chr 4:32,757,684...33,129,059 		JBrowse link
G ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr12:4,677,237...4,718,825
Ensembl chr12:4,677,229...4,714,386 		JBrowse link
G ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 9:60,538,718...60,625,903
Ensembl chr 9:60,540,303...60,625,570 		JBrowse link
G ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif 15 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:121,510,798...121,538,715
Ensembl chr 1:121,510,849...121,535,609 		JBrowse link
G ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif 16 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 Ensembl chr 4:4,866,477...4,967,550 JBrowse link
G ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif 17 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr29:18,484,341...18,842,210
Ensembl chr29:18,481,449...18,841,568 		JBrowse link
G ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif 18 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 5:62,764,081...62,921,394
Ensembl chr 5:62,765,939...62,918,697 		JBrowse link
G ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif 19 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr23:32,372,312...32,646,070
Ensembl chr23:32,372,515...32,646,071 		JBrowse link
G ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif 2 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr23:80,852,588...81,081,593
Ensembl chr23:80,852,331...81,080,218 		JBrowse link
G ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif 20 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr11:39,571,228...39,768,386
Ensembl chr11:39,572,013...39,767,590 		JBrowse link
G ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif 3 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 7:20,793,392...21,068,712
Ensembl chr 7:20,793,399...21,048,515 		JBrowse link
G ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr20:2,781,184...2,791,464
Ensembl chr20:2,783,855...2,792,170 		JBrowse link
G ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 2:65,252,922...65,359,167
Ensembl chr 2:65,254,285...65,299,800 		JBrowse link
G ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif 7 enables ISO (PMID:18485748) BHF-UCL PMID:18485748
G ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif 8 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:121,465,341...121,491,301
Ensembl chr 1:121,465,883...121,489,200 		JBrowse link
G ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif 9 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr22:25,545,518...25,720,512
Ensembl chr22:25,545,420...25,719,362 		JBrowse link
G ADAMTSL1 ADAMTS like 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr12:60,805,450...61,221,464
Ensembl chr12:60,805,479...61,056,333 		JBrowse link
G ADAMTSL2 ADAMTS like 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr12:4,562,213...4,602,494
Ensembl chr12:4,562,864...4,602,282 		JBrowse link
G ADAMTSL4 ADAMTS like 4 enables IEA TreeGrafter GO_REF:0000118
G ADAMTSL5 ADAMTS like 5 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 6:1,278,045...1,287,257
Ensembl chr 6:1,279,036...1,284,946 		JBrowse link
G AFG3L2 AFG3 like matrix AAA peptidase subunit 2 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr18:70,890,939...70,939,504
Ensembl chr18:70,891,554...70,939,352 		JBrowse link
G ASTL astacin like metalloendopeptidase enables IEA InterPro
UniProt
TreeGrafter		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chr14:568,071...577,182 JBrowse link
G ATP23 ATP23 metallopeptidase and ATP synthase assembly factor homolog enables IEA InterPro GO_REF:0000002 NCBI chr11:53,854,424...53,868,494
Ensembl chr11:53,854,418...53,868,628 		JBrowse link
G BMP1 bone morphogenetic protein 1 enables IEA InterPro
Ensembl
UniProt		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chr 8:20,234,242...20,281,768
Ensembl chr 8:20,234,184...20,283,467 		JBrowse link
G ECE1 endothelin converting enzyme 1 enables IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000118 NCBI chr20:111,212,567...111,342,755
Ensembl chr20:111,212,594...111,342,821 		JBrowse link
G ECE2 endothelin converting enzyme 2 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr15:5,131,038...5,148,829
Ensembl chr15:5,130,385...5,148,811 		JBrowse link
G ECEL1 endothelin converting enzyme like 1 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr10:118,500,297...118,507,775
Ensembl chr10:118,500,233...118,507,238 		JBrowse link
G IDE insulin degrading enzyme enables ISO
IEA		 atrial natriuretic peptide cleaved at the Ser25-Phe26 bond RGD
TreeGrafter
Ensembl
InterPro		 PMID:15494400 PMID:15749695 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1626704 RGD:1626705 NCBI chr 9:85,722,728...85,843,247
Ensembl chr 9:85,721,886...85,843,117 		JBrowse link
G KEL Kell metallo-endopeptidase (Kell blood group) enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr21:111,819,230...111,846,966
Ensembl chr21:111,819,368...111,840,142 		JBrowse link
G LMLN leishmanolysin like peptidase enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chr15:91,676,060...91,745,251
Ensembl chr15:91,676,379...91,744,928 		JBrowse link
G LOC103215661 disintegrin and metalloproteinase domain-containing protein 32 enables IEA InterPro GO_REF:0000002 NCBI chr 8:37,132,409...37,284,974
Ensembl chr 8:37,133,791...37,283,751 		JBrowse link
G LOC103215662 disintegrin and metalloproteinase domain-containing protein 5 enables IEA InterPro GO_REF:0000002 NCBI chr 8:37,324,591...37,444,377 JBrowse link
G LOC103215663 A disintegrin and metallopeptidase domain 3-like enables IEA InterPro GO_REF:0000002 NCBI chr 8:37,481,622...37,551,729 JBrowse link
G LOC103225750 membrane metallo-endopeptidase-like 1 enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:11964170 GO_REF:0000002 GO_REF:0000118 RGD:2314417 NCBI chr20:128,916,051...128,963,545
Ensembl chr20:128,921,369...128,963,188 		JBrowse link
G LOC103229265 disintegrin and metalloproteinase domain-containing protein 20 enables IEA InterPro GO_REF:0000002 NCBI chr24:47,730,284...47,733,329 JBrowse link
G MBTPS2 membrane bound transcription factor peptidase, site 2 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr  X:20,319,731...20,364,603
Ensembl chr  X:20,319,807...20,361,847 		JBrowse link
G MEP1A meprin A subunit alpha enables IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chr17:25,439,415...25,479,092
Ensembl chr17:25,439,442...25,473,681 		JBrowse link
G MEP1B meprin A subunit beta enables ISO
IEA		 RGD
TreeGrafter
UniProt
InterPro		 PMID:12437103 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 RGD:633322 NCBI chr18:48,519,933...48,551,223
Ensembl chr18:48,518,403...48,550,604 		JBrowse link
G MIPEP mitochondrial intermediate peptidase enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 3:3,578,057...3,726,783
Ensembl chr 3:3,578,193...3,726,746 		JBrowse link
G MME membrane metalloendopeptidase enables IEA UniProt
TreeGrafter
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr15:35,577,460...35,681,730
Ensembl chr15:35,580,714...35,633,914 		JBrowse link
G MMP1 matrix metallopeptidase 1 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:94,167,507...94,177,357
Ensembl chr 1:94,167,219...94,176,767 		JBrowse link
G MMP10 matrix metallopeptidase 10 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:94,147,995...94,158,315
Ensembl chr 1:94,148,087...94,158,097 		JBrowse link
G MMP11 matrix metallopeptidase 11 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr19:6,889,343...6,900,563
Ensembl chr19:6,889,385...6,899,788 		JBrowse link
G MMP12 matrix metallopeptidase 12 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:94,243,061...94,261,035
Ensembl chr 1:94,243,875...94,259,591 		JBrowse link
G MMP13 matrix metallopeptidase 13 enables ISO
IEA		 RGD
TreeGrafter
InterPro
Ensembl		 PMID:8910479 PMID:17941091 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:2296055 RGD:2298541 NCBI chr 1:94,322,473...94,370,665
Ensembl chr 1:94,322,979...94,334,747 		JBrowse link
G MMP14 matrix metallopeptidase 14 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr29:23,201,425...23,212,408
Ensembl chr29:23,201,112...23,212,679 		JBrowse link
G MMP15 matrix metallopeptidase 15 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 5:43,961,288...43,982,182
Ensembl chr 5:43,960,891...43,982,261 		JBrowse link
G MMP16 matrix metallopeptidase 16 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:83,122,904...83,407,910
Ensembl chr 8:83,132,315...83,407,933 		JBrowse link
G MMP17 matrix metallopeptidase 17 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr11:127,204,811...127,229,202
Ensembl chr11:127,214,890...127,230,731 		JBrowse link
G MMP19 matrix metallopeptidase 19 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr11:51,786,076...51,794,325 JBrowse link
G MMP2 matrix metallopeptidase 2 enables IEA Ensembl
TreeGrafter
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:41,264,382...41,291,657
Ensembl chr 5:41,264,354...41,291,004 		JBrowse link
G MMP20 matrix metallopeptidase 20 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:93,946,136...93,997,656
Ensembl chr 1:93,947,582...93,996,815 		JBrowse link
G MMP21 matrix metallopeptidase 21 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 9:118,387,926...118,400,048
Ensembl chr 9:118,389,666...118,398,807 		JBrowse link
G MMP23B matrix metallopeptidase 23B enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr20:129,873,838...129,876,521
Ensembl chr20:129,873,867...129,876,524 		JBrowse link
G MMP24 matrix metallopeptidase 24 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:56,153,277...56,183,026
Ensembl chr 2:56,152,944...56,184,605 		JBrowse link
G MMP25 matrix metallopeptidase 25 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 5:2,792,249...2,806,357
Ensembl chr 5:2,792,389...2,804,728 		JBrowse link
G MMP26 matrix metallopeptidase 26 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:61,826,835...61,832,152
Ensembl chr 1:61,827,321...61,831,374 		JBrowse link
G MMP27 matrix metallopeptidase 27 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:94,075,524...94,091,080
Ensembl chr 1:94,075,605...94,090,215 		JBrowse link
G MMP28 matrix metallopeptidase 28 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr16:29,241,938...29,272,231
Ensembl chr16:29,240,569...29,272,077 		JBrowse link
G MMP3 matrix metallopeptidase 3 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:94,216,156...94,224,437
Ensembl chr 1:94,216,173...94,224,264 		JBrowse link
G MMP7 matrix metallopeptidase 7 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:93,889,189...93,901,077
Ensembl chr 1:93,889,198...93,899,587 		JBrowse link
G MMP8 matrix metallopeptidase 8 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:94,097,620...94,110,114
Ensembl chr 1:94,097,896...94,109,432 		JBrowse link
G MMP9 matrix metallopeptidase 9 enables IEA Ensembl
TreeGrafter
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:17,867,267...17,874,757
Ensembl chr 2:17,867,177...17,874,712 		JBrowse link
G NLN neurolysin enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:7836437 GO_REF:0000002 GO_REF:0000118 RGD:9831155 NCBI chr 4:61,918,079...62,022,517
Ensembl chr 4:61,918,137...62,016,144 		JBrowse link
G NRDC nardilysin convertase enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr20:81,075,671...81,175,469
Ensembl chr20:81,075,869...81,175,447 		JBrowse link
G OMA1 OMA1 zinc metallopeptidase enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr20:74,435,190...74,500,220
Ensembl chr20:74,442,696...74,499,969 		JBrowse link
G PAPLN papilin, proteoglycan like sulfated glycoprotein enables IEA TreeGrafter GO_REF:0000118 NCBI chr24:50,479,932...50,528,284
Ensembl chr24:50,493,117...50,526,322 		JBrowse link
G PAPPA pappalysin 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr12:23,182,856...23,427,092
Ensembl chr12:23,184,704...23,427,165 		JBrowse link
G PAPPA2 pappalysin 2 enables ISO (PMID:11513734) Reactome PMID:11513734 NCBI chr25:52,432,178...52,729,671 JBrowse link
G PHEX phosphate regulating endopeptidase X-linked enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr  X:20,507,619...20,733,367
Ensembl chr  X:20,522,498...20,734,599 		JBrowse link
G PITRM1 pitrilysin metallopeptidase 1 enables ISO (PMID:16849325), (PMID:24931469)
(PMID:10360838), (PMID:19196155)		 UniProt PMID:10360838 PMID:16849325 PMID:19196155 PMID:24931469 NCBI chr 9:3,192,692...3,239,667 JBrowse link
G PITRM1 pitrilysin metallopeptidase 1 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 Ensembl chr 9:3,192,523...3,238,361 JBrowse link
G PMPCA peptidase, mitochondrial processing subunit alpha enables IEA InterPro GO_REF:0000002 NCBI chr12:1,778,376...1,791,878
Ensembl chr12:1,776,983...1,791,787 		JBrowse link
G PMPCB peptidase, mitochondrial processing subunit beta enables IEA UniProt
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000118 NCBI chr21:72,271,390...72,286,559
Ensembl chr21:72,271,429...72,286,265 		JBrowse link
G RCE1 Ras converting CAAX endopeptidase 1 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:7,420,221...7,526,495
Ensembl chr 1:7,420,653...7,423,265 		JBrowse link
G SPG7 SPG7 matrix AAA peptidase subunit, paraplegin enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:74,862,524...74,916,214
Ensembl chr 5:74,862,551...74,916,033 		JBrowse link
G SPRTN SprT-like N-terminal domain enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr25:68,599,377...68,620,568
Ensembl chr25:68,599,780...68,620,621 		JBrowse link
G THOP1 thimet oligopeptidase 1 enables ISO (PMID:10969067) MGI PMID:10969067 NCBI chr 6:2,564,445...2,590,029 JBrowse link
G THOP1 thimet oligopeptidase 1 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 Ensembl chr 6:2,564,481...2,583,948 JBrowse link
G THSD4 thrombospondin type 1 domain containing 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chr26:11,677,332...12,207,092
Ensembl chr26:11,683,231...11,912,098 		JBrowse link
G TLL1 tolloid like 1 enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chr 7:112,231,084...112,455,131
Ensembl chr 7:112,233,283...112,455,803 		JBrowse link
G TRABD2A TraB domain containing 2A enables IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr14:22,297,687...22,355,100
Ensembl chr14:22,297,888...22,354,844 		JBrowse link
G TRABD2B TraB domain containing 2B enables IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr20:84,932,091...85,162,560
Ensembl chr20:84,932,721...85,157,167 		JBrowse link
G UQCR2 ubiquinol-cytochrome c reductase core protein II enables IEA InterPro GO_REF:0000002 NCBI chr 5:19,622,884...19,653,667
Ensembl chr 5:19,623,410...19,653,479 		JBrowse link
G YBEY ybeY metalloendoribonuclease enables IEA InterPro GO_REF:0000002 NCBI chr 2:89,905,119...89,910,307
Ensembl chr 2:89,905,127...89,909,324 		JBrowse link
G YME1L1 YME1 like 1 ATPase enables IEA InterPro GO_REF:0000002 NCBI chr 9:26,703,747...26,752,274
Ensembl chr 9:26,703,992...26,752,340 		JBrowse link
G ZMPSTE24 zinc metallopeptidase STE24 enables IEA Ensembl
TreeGrafter
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr20:92,605,495...92,648,110
Ensembl chr20:92,605,309...92,648,114 		JBrowse link
metalloendopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM10 ADAM metallopeptidase domain 10 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr26:24,768,827...24,921,169
Ensembl chr26:24,768,915...24,919,009 		JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 enables IEA Ensembl GO_REF:0000107 NCBI chr14:98,092,093...98,157,657
Ensembl chr14:98,092,044...98,157,217 		JBrowse link
G ADAM19 ADAM metallopeptidase domain 19 enables IEA Ensembl GO_REF:0000107 NCBI chr23:59,867,949...59,966,873
Ensembl chr23:59,867,596...59,966,802 		JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 enables ISO (PMID:12054541) ARUK-UCL PMID:12054541 NCBI chr 8:37,017,827...37,131,462
Ensembl chr 8:37,017,545...37,131,615 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18050
    catalytic activity 5519
      hydrolase activity 2327
        peptidase activity 597
          endopeptidase activity 386
            metalloendopeptidase activity 108
              metalloendopeptidase activity involved in amyloid precursor protein catabolic process 4
paths to the root