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ONTOLOGY REPORT - ANNOTATIONS

Term:SAGA complex
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Accession:GO:0000124 term browser browse the term
Definition:A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695).
Synonyms:exact_synonym: Spt-Ada-Gcn5-acetyltransferase complex
 narrow_synonym: PCAF complex;   PCAF histone acetylase-associated complex;   SPT3-TAF9-PCAF acetylase complex
 related_synonym: SPT3-TAF9-GCN5 acetylase complex;   STAGA coactivator complex;   STAGA complex
 alt_id: GO:0000125;   GO:0030914


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SAGA complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATXN7L3 ataxin 7 like 3 part_of IEA UniProt
Ensembl
TreeGrafter		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr17:13,197,939...13,206,017
Ensembl chr17:13,362,312...13,369,667 		JBrowse link
G ENY2 ENY2 transcription and export complex 2 subunit part_of IEA InterPro
Ensembl
UniProt
TreeGrafter		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:105,985,043...105,996,686
Ensembl chr 8:108,129,883...108,141,478 		JBrowse link
G KAT2A lysine acetyltransferase 2A part_of IEA Ensembl GO_REF:0000107 NCBI chr17:15,194,414...15,202,818
Ensembl chr17:15,416,075...15,424,197 		JBrowse link
G LOC100994965 transcription factor SPT20 homolog-like 1 part_of IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr  X:16,959,582...16,962,840
Ensembl chr  X:24,328,255...24,330,798 		JBrowse link
G SGF29 SAGA complex associated factor 29 part_of IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 Ensembl chr16:29,030,587...29,068,795 JBrowse link
G SUPT20H SPT20 homolog, SAGA complex component part_of IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr13:18,217,142...18,268,937
Ensembl chr13:36,647,544...36,687,513 		JBrowse link
G SUPT3H SPT3 homolog, SAGA and STAGA complex component part_of IEA Ensembl GO_REF:0000107 NCBI chr 6:44,406,978...44,960,039 JBrowse link
G SUPT7L SPT7 like, STAGA complex subunit gamma part_of IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr2A:27,648,724...27,661,760
Ensembl chr2A:27,734,763...27,747,802 		JBrowse link
G TADA1 transcriptional adaptor 1 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:142,273,856...142,296,775
Ensembl chr 1:146,061,155...146,083,348 		JBrowse link
G TADA2A transcriptional adaptor 2A part_of ISO (PMID:9674425) UniProt PMID:9674425 NCBI chr17:19,595,055...19,670,090
Ensembl chr17:19,897,659...19,967,926 		JBrowse link
G TADA2B transcriptional adaptor 2B part_of IEA Ensembl GO_REF:0000107 Ensembl chr 4:7,110,732...7,125,100 JBrowse link
G TADA3 transcriptional adaptor 3 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:9,731,462...9,744,513
Ensembl chr 3:9,969,550...9,982,389 		JBrowse link
G TAF10 TATA-box binding protein associated factor 10 part_of ISO (PMID:11564863), (PMID:9674425) UniProt PMID:9674425 PMID:11564863 NCBI chr11:6,742,862...6,744,260 JBrowse link
G TAF12 TATA-box binding protein associated factor 12 part_of IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000117 NCBI chr 1:27,874,675...27,914,672 JBrowse link
G TAF5L TATA-box binding protein associated factor 5 like part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:205,137,767...205,170,704
Ensembl chr 1:210,168,379...210,200,903 		JBrowse link
G TAF6 TATA-box binding protein associated factor 6 part_of IEA InterPro GO_REF:0000002 NCBI chr 7:92,142,646...92,154,951
Ensembl chr 7:105,575,861...105,588,142 		JBrowse link
G TAF6L TATA-box binding protein associated factor 6 like part_of IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr11:58,126,480...58,142,752
Ensembl chr11:61,485,259...61,495,877 		JBrowse link
G TAF9 TATA-box binding protein associated factor 9 part_of ISO (PMID:11564863), (PMID:9674425) UniProt PMID:9674425 PMID:11564863 NCBI chr 5:44,630,503...44,635,760 JBrowse link
G TRRAP transformation/transcription domain associated protein part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 7:90,845,518...90,981,700
Ensembl chr 7:104,351,320...104,486,722 		JBrowse link
G USP22 ubiquitin specific peptidase 22 part_of IEA Ensembl GO_REF:0000107 NCBI chr17:30,606,845...30,650,281
Ensembl chr17:35,468,177...35,511,672 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 17180
    protein-containing complex 5905
      catalytic complex 1707
        peptidase complex 121
          SAGA complex 20
Path 2
Term Annotations click to browse term
  cellular_component 17180
    cellular anatomical entity 16965
      organelle 12482
        non-membrane-bounded organelle 4623
          intracellular non-membrane-bounded organelle 4616
            chromosome 1262
              chromatin 750
                histone acetyltransferase complex 88
                  SAGA-type complex 35
                    SAGA complex 20
paths to the root