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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Experimental Autoimmune Uveitis
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Accession:DOID:9005647 term browser browse the term
Definition:An experimental animal model used for the study of uveitis. It is commonly induced with interphotoreceptor retinoid-binding protein (IRBP) (relapsing EAU) or retinal S-Antigen (monophasic EAU).
Synonyms:related_synonym: EAAU;   experimental autoimmune anterior uveitis


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Experimental Autoimmune Uveitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 ISO mRNA:increased expression:iris, ciliary body, popliteal lymph nodes (rat) RGD PMID:15109911 RGD:8549495 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G CCR2 C-C motif chemokine receptor 2 no_association ISO RGD PMID:19357362 PMID:24736166 RGD:8657357 RGD:8657383 NCBI chr20:42,305,344...42,313,258
Ensembl chr20:42,307,580...42,308,698 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 ISO RGD PMID:11481266 PMID:14528321 RGD:7204514 RGD:7421509 NCBI chr37:12,647,712...12,653,874
Ensembl chr37:12,634,563...12,653,874 		JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO mRNA, protein:increased expression:iris, ciliary body, aqueous humor RGD PMID:16030495 RGD:9479740 NCBI chr 2:59,022,794...59,032,095
Ensembl chr 2:59,022,794...59,032,095 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:16030495 PMID:19689733 RGD:9479740 RGD:9491397 NCBI chr23:8,937,069...8,954,738
Ensembl chr23:8,938,906...8,952,808 		JBrowse link
G DLA88 MHC class I DLA-88 treatment ISO human peptide in rat model; HLA-B27
human HLA-B27 peptide in rat model		 RGD PMID:9232451 PMID:15681796 RGD:7364916 RGD:7364942 NCBI chr12:892,442...895,691
Ensembl chr12:892,388...1,021,690 		JBrowse link
G DLL4 delta like canonical Notch ligand 4 disease_progression ISO RGD PMID:31209505 RGD:155791448 NCBI chr30:8,059,463...8,068,742
Ensembl chr30:8,059,512...8,067,940 		JBrowse link
G FAS Fas cell surface death receptor susceptibility ISO RGD PMID:11067900 RGD:8662852 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 treatment ISO RGD PMID:8100190 RGD:8158117 NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914 		JBrowse link
G IL10 interleukin 10 disease_progression
treatment		 ISO RGD PMID:16043105 PMID:18390724 PMID:18495789 PMID:31209505 RGD:155791448 RGD:7365044 RGD:7365052 RGD:7365069 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057 		JBrowse link
G IL17A interleukin 17A treatment ISO mRNA:increased expression:lymph node (rat) RGD PMID:21686325 PMID:23626769 PMID:24117055 RGD:9074484 RGD:9158567 RGD:9173789 NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO human protein in mouse model RGD PMID:16009838 RGD:8549788 NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329 		JBrowse link
G MMP1 matrix metallopeptidase 1 onset ISO mRNA, protein:increased expression:eye (rat) RGD PMID:19755419 RGD:7207388 NCBI chr 5:28,978,385...28,986,644
Ensembl chr 5:28,978,473...28,986,648 		JBrowse link
G NOTCH1 notch receptor 1 disease_progression ISO RGD PMID:31209505 RGD:155791448 NCBI chr 9:48,975,972...49,018,985
Ensembl chr 9:48,974,757...49,017,277 		JBrowse link
G RPE65 retinoid isomerohydrolase RPE65 ISO human peptides in a rat model RGD PMID:16109648 RGD:9585652 NCBI chr 6:76,887,399...76,911,133
Ensembl chr 6:76,887,399...76,911,131 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 ameliorates ISO RGD PMID:24993154 RGD:151232288 NCBI chr 6:31,511,003...31,511,995
Ensembl chr 6:31,509,268...31,511,557 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 treatment ISO RGD PMID:22238646 RGD:8694304 NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:20207969 RGD:7794846 NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165 		JBrowse link
Experimental Autoimmune Uveoretinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE2 angiotensin converting enzyme 2 treatment ISO human gene in a mouse model RGD PMID:25228068 RGD:40818264 NCBI chr  X:11,798,839...11,839,591
Ensembl chr  X:11,798,839...11,900,594 		JBrowse link
G C3 complement C3 ISO RGD PMID:16143328 RGD:7401262 NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO mRNA:increased expression:eye: RGD PMID:12605265 RGD:8661671 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO mRNA:increased expression:eye: RGD PMID:12605265 RGD:8661671 NCBI chr20:42,305,344...42,313,258
Ensembl chr20:42,307,580...42,308,698 		JBrowse link
G CD40LG CD40 ligand treatment ISO RGD PMID:15972638 RGD:8547777 NCBI chr  X:107,001,421...107,023,007
Ensembl chr  X:107,010,890...107,023,006 		JBrowse link
G CFB complement factor B treatment ISO RGD PMID:20806290 PMID:21216963 RGD:7411717 RGD:7411732 NCBI chr12:1,400,143...1,406,267 JBrowse link
G ICAM1 intercellular adhesion molecule 1 treatment ISO RGD PMID:7909311 RGD:8547706 NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914 		JBrowse link
G IFNG interferon gamma ISO mRNA,protein:increased expression:eye: RGD PMID:1572694 RGD:8142388 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:11359436 PMID:15240742 PMID:21296818 PMID:22629453 RGD:7364830 RGD:7364849 RGD:7365075 RGD:7365084 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057 		JBrowse link
G IL2 interleukin 2 disease_progression ISO mRNA:increased expression:uvea: RGD PMID:7803357 PMID:7929845 RGD:8662946 RGD:8662951 NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394 		JBrowse link
G IL4 interleukin 4 disease_progression ISO mRNA:increased expression:uvea: RGD PMID:7803357 RGD:8662946 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO RGD PMID:18424728 RGD:8694299 NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO RGD PMID:19635911 RGD:8661744 NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15602
    Animal Diseases 1332
      Animal Disease Models 1285
        Experimental Autoimmune Uveitis 26
          Experimental Autoimmune Uveoretinitis 13
Path 2
Term Annotations click to browse term
  disease 15602
    disease of anatomical entity 15181
      nervous system disease 13236
        Neurologic Manifestations 9584
          sensory system disease 6610
            eye disease 3379
              uveal disease 229
                uveitis 129
                  Experimental Autoimmune Uveitis 26
                    Experimental Autoimmune Uveoretinitis 13
paths to the root