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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:signet ring cell adenocarcinoma
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Accession:DOID:3493 term browser browse the term
Definition:An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which have signet ring appearance. (DO)
Synonyms:exact_synonym: signet ring carcinoma;   signet ring cell carcinoma
 primary_id: MESH:D018279
 xref: EFO:0000698;   NCI:C3774
For additional species annotation, visit the Alliance of Genome Resources.


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signet ring cell adenocarcinoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tff1 trefoil factor 1 ISO protein:increased expression:urinary bladder RGD PMID:18283638 RGD:2291996 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
colon signet ring adenocarcinoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Runx1 RUNX family transcription factor 1 ISO mRNA:increased expression:colon RGD PMID:29747153 RGD:126779566 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
Krukenberg carcinoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule ISO protein:increased expression:ovary RGD PMID:16124061 RGD:2289359 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18969
    disease of cellular proliferation 7692
      Neoplasms by Histologic Type 5288
        Glandular and Epithelial Neoplasms 3738
          Cystic, Mucinous, and Serous Neoplasms 42
            signet ring cell adenocarcinoma 3
              Krukenberg carcinoma 1
              ampullary signet ring cell adenocarcinoma 0
              bile duct signet ring cell carcinoma 0
              bladder signet ring cell adenocarcinoma 0
              breast signet ring cell adenocarcinoma 0
              colon signet ring adenocarcinoma 1
              gallbladder signet ring cell adenocarcinoma 0
              gastric signet ring cell adenocarcinoma 0
              pancreatic signet ring cell adenocarcinoma 0
              prostate signet ring cell adenocarcinoma 0
              rectum signet ring adenocarcinoma 0
              signet ring basal cell carcinoma 0
              signet ring cell intrahepatic cholangiocarcinoma 0
              signet ring lung adenocarcinoma 0
Path 2
Term Annotations click to browse term
  disease 18969
    disease of cellular proliferation 7692
      cancer 5509
        cell type cancer 3760
          carcinoma 3201
            adenocarcinoma 1713
              signet ring cell adenocarcinoma 3
                Krukenberg carcinoma 1
                ampullary signet ring cell adenocarcinoma 0
                bile duct signet ring cell carcinoma 0
                bladder signet ring cell adenocarcinoma 0
                breast signet ring cell adenocarcinoma 0
                colon signet ring adenocarcinoma 1
                gallbladder signet ring cell adenocarcinoma 0
                gastric signet ring cell adenocarcinoma 0
                pancreatic signet ring cell adenocarcinoma 0
                prostate signet ring cell adenocarcinoma 0
                rectum signet ring adenocarcinoma 0
                signet ring basal cell carcinoma 0
                signet ring cell intrahepatic cholangiocarcinoma 0
                signet ring lung adenocarcinoma 0
paths to the root