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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Pulmonary Hypertension, Hypoxia-Induced
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Accession:DOID:9006166 term browser browse the term
Definition:Increased vascular resistance in the pulmonary circulation, secondary to hypoxia.
Synonyms:primary_id: RDO:9000421

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Pulmonary Hypertension, Hypoxia-Induced term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor treatment ISO RGD PMID:33836606 RGD:401940192 NCBI chrNW_004936546:3,737,908...3,783,492
Ensembl chrNW_004936546:3,737,851...3,783,588 		JBrowse link
G Egfr epidermal growth factor receptor treatment ISO RGD PMID:31264901 RGD:38599217 NCBI chrNW_004936678:365,005...560,546
Ensembl chrNW_004936678:365,834...436,528 		JBrowse link
G Egln1 egl-9 family hypoxia inducible factor 1 ISO RGD PMID:16761101 RGD:11252085 NCBI chrNW_004936484:19,343,770...19,386,087 JBrowse link
G Egln3 egl-9 family hypoxia inducible factor 3 ISO RGD PMID:16761101 RGD:11252085 NCBI chrNW_004936494:8,240,272...8,267,487
Ensembl chrNW_004936494:8,238,858...8,267,606 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase treatment ISO RGD PMID:25063801 RGD:10449119 NCBI chrNW_004936809:1,269,900...1,285,853
Ensembl chrNW_004936809:1,269,914...1,285,889 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 ISO mRNA:decreased expression:lung (rat) RGD PMID:19823174 RGD:4145499 NCBI chrNW_004936636:617,376...640,424
Ensembl chrNW_004936636:617,356...640,932 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase ISO mRNA, protein:increased expression:lung RGD PMID:24657469 RGD:11667099 NCBI chrNW_004936516:5,551,192...5,578,796
Ensembl chrNW_004936516:5,550,203...5,578,832 		JBrowse link
G LOC101969148 cytochrome P450 1A1 ISO mRNA:increased expression:lung (rat) RGD PMID:33836606 RGD:401940192 NCBI chrNW_004936471:33,682,730...33,688,332
Ensembl chrNW_004936471:33,682,730...33,688,332 		JBrowse link
G Mfn2 mitofusin 2 ISO mRNA, protein:decreased expression:lung (rat) RGD PMID:26485208 RGD:12910856 NCBI chrNW_004936474:767,754...795,258
Ensembl chrNW_004936474:767,671...796,556 		JBrowse link
G Nog noggin ISO mRNA,protein:decreased expression:lung: RGD PMID:25740156 RGD:12801489 NCBI chrNW_004936490:6,262,651...6,264,069
Ensembl chrNW_004936490:6,262,785...6,263,483 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO mRNA,protein:increased expression:pulmonary artery RGD PMID:9950873 RGD:11533933 NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534 		JBrowse link
G Pcna proliferating cell nuclear antigen ISO protein:increased expression:lung (rat) RGD PMID:26485208 RGD:12910856 NCBI chrNW_004936485:13,766,221...13,771,215 JBrowse link
G Ptgis prostaglandin I2 synthase treatment ISO RGD PMID:12062720 RGD:401959327 NCBI chrNW_004936514:4,775,884...4,814,574
Ensembl chrNW_004936514:4,791,031...4,812,027 		JBrowse link
G Ptprd protein tyrosine phosphatase receptor type D ISO mRNA, protein:decreased expression:pulmonary artery (rat) RGD PMID:35848503 RGD:401976433 NCBI chrNW_004936539:2,564,815...3,369,975
Ensembl chrNW_004936539:2,564,793...2,945,293 		JBrowse link
G Slc39a12 solute carrier family 39 member 12 severity ISO RGD PMID:26258299 RGD:10401832 NCBI chrNW_004936520:9,380,723...9,444,146
Ensembl chrNW_004936520:9,380,650...9,444,152 		JBrowse link
G Sox17 SRY-box transcription factor 17 exacerbates ISO protein:decreased expression:pulmonary artery endothelium (mouse) RGD PMID:36205124 PMID:36913491 PMID:36919784 PMID:37066790 RGD:329853316 RGD:329853317 RGD:329853734 RGD:329853737 NCBI chrNW_004936496:1,248,582...1,251,406
Ensembl chrNW_004936496:1,248,577...1,251,430 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14511
    disease of anatomical entity 14163
      respiratory system disease 3172
        lower respiratory tract disease 2033
          lung disease 1996
            pulmonary hypertension 360
              Pulmonary Hypertension, Hypoxia-Induced 16
Path 2
Term Annotations click to browse term
  disease 14511
    disease of anatomical entity 14163
      cardiovascular system disease 4140
        vascular disease 2905
          artery disease 1927
            hypertension 954
              pulmonary hypertension 360
                Pulmonary Hypertension, Hypoxia-Induced 16
paths to the root