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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:malignant pleural mesothelioma
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Accession:DOID:7474 term browser browse the term
Definition:A pleural cancer that has_material_basis_in mesothelium cells. (DO)
Synonyms:exact_synonym: malignant mesothelioma of pleura
 narrow_synonym: Pleural Sarcomatoid Mesothelioma
 xref: EFO:0000770;   EFO:1000486;   ICD10CM:C45.0;   NCI:C7376
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
malignant pleural mesothelioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAP1 BRCA1 associated protein 1 disease_progression IEP RGD PMID:27422796 RGD:127229946 NCBI chr 3:52,401,008...52,410,008
Ensembl chr 3:52,401,008...52,410,008 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 exacerbates HEP mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636 		JBrowse link
G BIRC7 baculoviral IAP repeat containing 7 ameliorates HEP mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr20:63,235,905...63,240,495
Ensembl chr20:63,235,883...63,240,495 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit ameliorates IMP RGD PMID:18722110 RGD:151667912 NCBI chr15:32,030,483...32,173,018
Ensembl chr15:31,923,438...32,173,018 		JBrowse link
G CSF1R colony stimulating factor 1 receptor HEP mRNA:increased expression:peritoneum�� (human) RGD PMID:24722292 RGD:150524278 NCBI chr 5:150,053,295...150,113,365
Ensembl chr 5:150,053,291...150,113,372 		JBrowse link
G EMX2 empty spiracles homeobox 2 exacerbates IEP mRNA:decreased expression:mesothelium of pleural cavity (human) RGD PMID:25023662 RGD:153323312 NCBI chr10:117,542,746...117,549,546
Ensembl chr10:117,542,445...117,549,546 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit disease_progression IEP mRNA, protein:increased expression:pleura RGD PMID:22028491 RGD:126781718 NCBI chr 7:148,807,383...148,884,291
Ensembl chr 7:148,807,257...148,884,321 		JBrowse link
G IL7R interleukin 7 receptor disease_progression IEP RGD PMID:26155428 RGD:151347688 NCBI chr 5:35,856,891...35,879,603
Ensembl chr 5:35,852,695...35,879,603 		JBrowse link
G KDM6A lysine demethylase 6A IEP mRNA:increased expression:mesothelium of pleural cavity (human) RGD PMID:28197626 RGD:150429737 NCBI chr  X:44,873,188...45,112,779
Ensembl chr  X:44,873,188...45,112,779 		JBrowse link
G MIR192 microRNA 192 IEP miRNA:decreased expression:pleura (human) RGD PMID:26125439 RGD:11529530 NCBI chr11:64,891,137...64,891,246
Ensembl chr11:64,891,137...64,891,246 		JBrowse link
G MIR193A microRNA 193a IEP miRNA:decreased expression:pleura (human) RGD PMID:26125439 RGD:11529530 NCBI chr17:31,559,996...31,560,083
Ensembl chr17:31,559,996...31,560,083 		JBrowse link
G MIR200B microRNA 200b IEP miRNA:decreased expression:pleura (human) RGD PMID:26125439 RGD:11529530 NCBI chr 1:1,167,104...1,167,198
Ensembl chr 1:1,167,104...1,167,198 		JBrowse link
G MLH1 mutL homolog 1 disease_progression IEP RGD PMID:23810210 RGD:126848799 NCBI chr 3:36,993,466...37,050,846
Ensembl chr 3:36,993,226...37,050,896 		JBrowse link
G NCOA2 nuclear receptor coactivator 2 ameliorates IEP protein:increased expression:mesothelium of pleural cavity (human) RGD PMID:22011668 RGD:153002578 NCBI chr 8:70,109,782...70,456,446
Ensembl chr 8:70,109,782...70,403,808 		JBrowse link
G NF2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor disease_progression IEP
IAGP		 DNA:loss of heterozygosity RGD PMID:27378628 PMID:26493618 PMID:26928227 RGD:150530638, RGD:11553131, RGD:150429647 NCBI chr22:29,603,556...29,698,600
Ensembl chr22:29,603,553...29,698,598 		JBrowse link
G RAD21 RAD21 cohesin complex component HEP RGD PMID:19380173 RGD:150520037 NCBI chr 8:116,845,934...116,874,776
Ensembl chr 8:116,845,934...116,874,776 		JBrowse link
G SETD2 SET domain containing 2, histone lysine methyltransferase disease_progression IAGP
IEP		 DNA:mutations:CDS:multiple (human) RGD PMID:26928227 PMID:33691361 RGD:150429647, RGD:150520202 NCBI chr 3:47,016,436...47,164,840
Ensembl chr 3:47,016,428...47,164,113 		JBrowse link
G SLC7A5 solute carrier family 7 member 5 disease_progression IEP protein:increased expression:pleura RGD PMID:22199264 PMID:24912849 RGD:151361201, RGD:151660330 NCBI chr16:87,830,023...87,869,507
Ensembl chr16:87,830,023...87,869,507 		JBrowse link
G SMO smoothened, frizzled class receptor disease_progression IEP
IAGP		 DNA:missense mutations RGD PMID:23379358 PMID:33209614 RGD:150521620, RGD:150521621 NCBI chr 7:129,188,633...129,213,545
Ensembl chr 7:129,188,633...129,213,545 		JBrowse link
G XIAP X-linked inhibitor of apoptosis ameliorates HEP mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 35773
    disease of anatomical entity 32516
      respiratory system disease 4145
        Respiratory Tract Neoplasms 1094
          respiratory system cancer 858
            malignant pleural mesothelioma 20
              lymphohistiocytoid mesothelioma 0
Path 2
Term Annotations click to browse term
  disease 35773
    disease of anatomical entity 32516
      respiratory system disease 4145
        thoracic disease 2112
          Thoracic Neoplasms 1601
            Respiratory Tract Neoplasms 1094
              Pleural Neoplasms 25
                pleural cancer 20
                  malignant pleural mesothelioma 20
                    lymphohistiocytoid mesothelioma 0
paths to the root