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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:oligodendroglioma
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Accession:DOID:3181 term browser browse the term
Definition:A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)
Synonyms:exact_synonym: oligodendroblastoma;   oligodendroblastomas;   oligodendroglial neoplasm;   oligodendroglial tumor;   oligodendrogliomas;   well differentiated oligodendroglioma;   well-differentiated oligodendrogliomas
 narrow_synonym: Mixed Oligodendroglioma Astrocytoma;   Mixed Oligodendroglioma Ependymoma;   mixed oligodendroglioma-astrocytomas;   mixed oligodendroglioma-ependymomas
 primary_id: MESH:D009837
 xref: EFO:0000631;   EFO:0000632;   GARD:9953;   ICDO:9450/3;   NCI:C129319;   NCI:C3288;   NCI:C6960
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
oligodendroglioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atrx ATRX, chromatin remodeler ISO ClinVar Annotator: match by term: Oligodendroglioma ClinVar NCBI chr  X:104,841,221...104,972,978
Ensembl chr  X:104,841,221...104,973,009 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II, beta disease_progression IEP RGD PMID:15750623 RGD:13702479 NCBI chr11:5,919,642...6,016,401
Ensembl chr11:5,919,644...6,016,362 		JBrowse link
G Cic capicua transcriptional repressor ISO ClinVar Annotator: match by term: Oligodendroglioma ClinVar NCBI chr 7:24,967,054...24,993,584
Ensembl chr 7:24,967,129...24,993,584 		JBrowse link
G Dtx1 deltex 1, E3 ubiquitin ligase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21127729 NCBI chr 5:120,818,268...120,850,879
Ensembl chr 5:120,818,267...120,849,992 		JBrowse link
G Egf epidermal growth factor susceptibility ISO DNA:polymorphism:promoter:GG genotypes were associated with increased risk. RGD PMID:17473192 RGD:13702474 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19138852 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21127729 NCBI chr16:29,883,259...29,886,614
Ensembl chr16:29,883,202...29,886,614 		JBrowse link
G Hey1 hairy/enhancer-of-split related with YRPW motif 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21127729 NCBI chr 3:8,728,419...8,732,098
Ensembl chr 3:8,728,419...8,732,316 		JBrowse link
G Idh1 isocitrate dehydrogenase 1 (NADP+), soluble ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Oligodendroglioma		 CTD
ClinVar		 PMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:20160062 More... NCBI chr 1:65,197,775...65,225,638
Ensembl chr 1:65,197,775...65,225,659 		JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD PMID:20160062 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase ISO DNA:hypermethylation:promoter (human) RGD PMID:15455350 RGD:2317688 NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995 		JBrowse link
G Ptges3 prostaglandin E synthase 3 ISO protein:increased expression:brain cortex, white matter (human) RGD PMID:19347995 RGD:5688067 NCBI chr10:127,894,851...127,913,123
Ensembl chr10:127,894,823...127,913,141 		JBrowse link
G Rb1 RB transcriptional corepressor 1 disease_progression ISO RGD PMID:15970925 RGD:13782064 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262 		JBrowse link
anaplastic oligodendroglioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cic capicua transcriptional repressor ISO ClinVar Annotator: match by term: Anaplastic oligodendroglioma ClinVar NCBI chr 7:24,967,054...24,993,584
Ensembl chr 7:24,967,129...24,993,584 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16121
    disease of cellular proliferation 7571
      cancer 5523
        cell type cancer 3840
          high grade glioma 708
            oligodendroglioma 13
              adult oligodendroglioma 0
              anaplastic oligodendroglioma + 1
              brain oligodendroglioma + 0
              childhood oligodendroglioma 0
              spinal cord oligodendroglioma 0
Path 2
Term Annotations click to browse term
  disease 16121
    disease of anatomical entity 15680
      nervous system disease 13560
        central nervous system disease 12117
          Central Nervous System Neoplasms 1431
            Brain Neoplasms 1382
              brain cancer 765
                high grade glioma 708
                  oligodendroglioma 13
                    adult oligodendroglioma 0
                    anaplastic oligodendroglioma + 1
                    brain oligodendroglioma + 0
                    childhood oligodendroglioma 0
                    spinal cord oligodendroglioma 0
paths to the root