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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:leptospirosis
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Accession:DOID:2297 term browser browse the term
Definition:A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. The infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly. (DO)
Synonyms:exact_synonym: Fort Bragg fever;   Stuttgart disease;   cane cutter fever;   leptospira canicola infection;   leptospira canicola infections;   leptospiroses;   leptospirosis canicola;   leptospirosis canicolas;   leptospirosis icterohaemorrhagica;   mud fever;   nanukayami fever;   rat catcher's yellows;   rice field fever;   spirochetal jaundice
 primary_id: MESH:D007922
 xref: EFO:0007344;   GARD:7881;   ICD10CM:A27;   ICD10CM:A27.0;   ICD9CM:100;   ICD9CM:100.0;   NCI:C84825
For additional species annotation, visit the Alliance of Genome Resources.


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leptospirosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Yt blood group) ISO RGD PMID:21921108 RGD:5688128 NCBI chr 7:92,915,065...92,922,079
Ensembl chr 7:106,311,944...106,318,184 		JBrowse link
G ADA adenosine deaminase ISO RGD PMID:21320715 RGD:5128858 NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868 		JBrowse link
G BCHE butyrylcholinesterase ISO protein:increased expression:serum RGD PMID:21921108 RGD:5688128 NCBI chr 3:162,794,184...162,858,574
Ensembl chr 3:170,845,494...170,911,481 		JBrowse link
G F2 coagulation factor II, thrombin severity ISO protein:increased expression:blood plasma (human) RGD PMID:18171258 PMID:20002620 RGD:40818429 RGD:40819859 NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157 		JBrowse link
G IL1B interleukin 1 beta ISO mRNA, protein:increased expression:kidney (mouse) RGD PMID:22323544 RGD:7175257 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G MBL2 mannose binding lectin 2 severity ISO protein:increased expression:serum RGD PMID:19330263 RGD:6903260 NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:19635914 RGD:7240557 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:16428731 PMID:19635914 RGD:7240557 RGD:7241090 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15685
    disease by infectious agent 2107
      Bacterial Infections and Mycoses 1011
        bacterial infectious disease 802
          primary bacterial infectious disease 186
            leptospirosis 8
              Weil Disease 0
paths to the root