ADA (adenosine deaminase) - Rat Genome Database

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Pathways
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Gene: ADA (adenosine deaminase) Pan paniscus
Analyze
Symbol: ADA
Name: adenosine deaminase
RGD ID: 12028673
Description: ENCODES a protein that exhibits adenosine deaminase activity (ortholog); purine nucleoside binding (ortholog); INVOLVED IN adenosine catabolic process (ortholog); adenosine metabolic process (ortholog); alpha-beta T cell differentiation (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH adenosine deaminase deficiency (ortholog); asthma (ortholog); autism spectrum disorder (ortholog); FOUND IN cytosol (ortholog); dendrite cytoplasm (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,352,747 - 50,384,972 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,345,850 - 50,378,060 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02040,950,238 - 40,982,481 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,044,613 - 42,076,868 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,044,613 - 42,076,868 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenosine deaminase deficiency  (ISO)
asthma  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Cadmium Poisoning  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
colon cancer  (ISO)
colorectal cancer  (ISO)
Coronary Disease  (ISO)
diabetes mellitus  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial hyperlipidemia  (ISO)
focal epilepsy  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
Hyperemia  (ISO)
hyperglycemia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
laryngeal squamous cell carcinoma  (ISO)
Legionnaires' disease  (ISO)
leptospirosis  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lymphopenia  (ISO)
malignant mesothelioma  (ISO)
Malignant Pleural Effusions  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
Myocardial Reperfusion Injury  (ISO)
obesity  (ISO)
oral cavity cancer  (ISO)
oral squamous cell carcinoma  (ISO)
peritonitis  (ISO)
Pleural Effusion  (ISO)
pleural tuberculosis  (ISO)
pleurisy  (ISO)
primary immunodeficiency disease  (ISO)
pulmonary edema  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Q fever  (ISO)
severe combined immunodeficiency  (ISO)
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive  (ISO)
spinal cord disease  (ISO)
sporotrichosis  (ISO)
stomach cancer  (ISO)
T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations  (ISO)
tongue squamous cell carcinoma  (ISO)
trypanosomiasis  (ISO)
type 2 diabetes mellitus  (ISO)
uterine fibroid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenosine catabolic process  (IEA,ISO)
adenosine metabolic process  (IEA,ISO)
allantoin metabolic process  (IEA)
alpha-beta T cell differentiation  (IEA,ISO)
amide catabolic process  (IEA)
AMP catabolic process  (IEA)
AMP salvage  (IEA)
apoptotic process  (IEA,ISO)
B cell proliferation  (IEA,ISO)
calcium-mediated signaling  (IEA,ISO)
dAMP catabolic process  (IEA)
dATP catabolic process  (IEA,ISO)
deoxyadenosine catabolic process  (IEA,ISO)
embryonic digestive tract development  (IEA,ISO)
germinal center B cell differentiation  (IEA,ISO)
germinal center formation  (IEA,ISO)
GMP salvage  (IEA)
histamine secretion  (ISO)
hypoxanthine biosynthetic process  (IEA,ISO)
hypoxanthine salvage  (IEA)
in utero embryonic development  (IEA,ISO)
inosine biosynthetic process  (IEA,ISO)
leukocyte migration  (IEA,ISO)
liver development  (IEA,ISO)
lung alveolus development  (IEA,ISO)
lung development  (IEA,ISO)
mature B cell apoptotic process  (IEA,ISO)
mucus secretion  (IEA,ISO)
negative regulation of adenosine receptor signaling pathway  (IEA)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of circadian sleep/wake cycle, non-REM sleep  (ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of leukocyte migration  (IEA,ISO)
negative regulation of mature B cell apoptotic process  (IEA,ISO)
negative regulation of mucus secretion  (IEA,ISO)
negative regulation of penile erection  (IEA,ISO)
negative regulation of thymocyte apoptotic process  (IEA,ISO)
nucleotide metabolic process  (IEA)
penile erection  (IEA,ISO)
Peyer's patch development  (IEA,ISO)
placenta development  (IEA,ISO)
positive regulation of alpha-beta T cell differentiation  (IEA,ISO)
positive regulation of B cell proliferation  (IEA,ISO)
positive regulation of calcium-mediated signaling  (IEA,ISO)
positive regulation of germinal center formation  (IEA,ISO)
positive regulation of heart rate  (IEA,ISO)
positive regulation of smooth muscle contraction  (IEA,ISO)
positive regulation of T cell activation  (IEA,ISO)
positive regulation of T cell differentiation  (IEA,ISO)
positive regulation of T cell differentiation in thymus  (IEA,ISO)
positive regulation of T cell receptor signaling pathway  (IEA,ISO)
purine nucleotide salvage  (IEA)
purine ribonucleoside monophosphate biosynthetic process  (IEA)
regulation of cell-cell adhesion mediated by integrin  (IEA)
regulation of circadian sleep/wake cycle, sleep  (ISO)
regulation of T cell differentiation  (IEA,ISO)
regulation of T cell differentiation in thymus  (ISO)
response to cadmium ion  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (IEA,ISO)
response to inorganic substance  (IEA)
response to L-arginine  (ISO)
response to purine-containing compound  (IEA)
response to vitamin E  (ISO)
response to xenobiotic stimulus  (ISO)
smooth muscle contraction  (IEA,ISO)
T cell activation  (IEA,ISO)
T cell differentiation  (IEA,ISO)
T cell differentiation in thymus  (IEA,ISO)
T cell receptor signaling pathway  (IEA,ISO)
thymocyte apoptotic process  (IEA,ISO)
trophectodermal cell differentiation  (IEA,ISO)
xanthine biosynthetic process  (IEA,ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,352,747 - 50,384,972 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,345,850 - 50,378,060 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02040,950,238 - 40,982,481 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,044,613 - 42,076,868 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,044,613 - 42,076,868 (-)Ensemblpanpan1.1panPan2
ADA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382044,619,522 - 44,651,699 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2044,584,896 - 44,652,252 (-)EnsemblGRCh38hg38GRCh38
GRCh372043,248,163 - 43,280,340 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362042,681,577 - 42,713,790 (-)NCBINCBI36Build 36hg18NCBI36
Build 342042,681,577 - 42,713,790NCBI
Celera2039,956,805 - 39,989,017 (-)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2039,989,704 - 40,021,872 (-)NCBIHuRef
CHM1_12043,151,279 - 43,183,492 (-)NCBICHM1_1
T2T-CHM13v2.02046,355,294 - 46,387,474 (-)NCBIT2T-CHM13v2.0
Ada
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392163,565,703 - 163,592,154 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2163,568,504 - 163,592,159 (-)EnsemblGRCm39 Ensembl
GRCm382163,726,571 - 163,750,239 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2163,726,584 - 163,750,239 (-)EnsemblGRCm38mm10GRCm38
MGSCv372163,552,320 - 163,575,913 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362163,418,025 - 163,441,618 (-)NCBIMGSCv36mm8
Celera2169,670,309 - 169,693,933 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.44NCBI
Ada
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83172,818,174 - 172,842,283 (-)NCBIGRCr8
mRatBN7.23152,398,745 - 152,422,854 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,398,747 - 152,447,088 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3156,206,205 - 156,230,314 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03164,705,138 - 164,729,255 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03162,449,261 - 162,473,358 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,115,840 - 160,139,947 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,115,842 - 160,139,947 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,306,001 - 166,330,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43154,636,530 - 154,660,637 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13154,542,567 - 154,566,673 (-)NCBI
Celera3151,051,040 - 151,075,153 (-)NCBICelera
Cytogenetic Map3q42NCBI
Ada
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544512,696,096 - 12,717,488 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544512,696,096 - 12,717,488 (+)NCBIChiLan1.0ChiLan1.0
ADA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,083,786 - 32,119,810 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2432,083,931 - 32,111,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2431,725,150 - 31,756,275 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02432,790,716 - 32,821,895 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2432,790,730 - 32,818,187 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12432,052,411 - 32,083,510 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02432,167,117 - 32,198,181 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02432,708,375 - 32,739,510 (-)NCBIUU_Cfam_GSD_1.0
Ada
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640181,082,150 - 181,103,907 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365302,217,713 - 2,224,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1747,044,497 - 47,072,245 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11747,044,492 - 47,072,232 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21752,502,115 - 52,544,469 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1219,167,209 - 19,200,233 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605067,836,179 - 67,868,616 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ada
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247909,809,492 - 9,829,883 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247909,809,550 - 9,829,199 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000027452   ⟹   ENSPPAP00000006326
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2042,044,613 - 42,076,868 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000027456   ⟹   ENSPPAP00000006328
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2042,044,615 - 42,076,868 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000027466   ⟹   ENSPPAP00000006331
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2042,045,214 - 42,062,663 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000027469   ⟹   ENSPPAP00000006333
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2042,046,230 - 42,062,663 (-)Ensembl
RefSeq Acc Id: XM_003825933   ⟹   XP_003825981
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,352,747 - 50,384,972 (-)NCBI
NHGRI_mPanPan12050,345,850 - 50,378,060 (-)NCBI
Mhudiblu_PPA_v02040,950,238 - 40,982,451 (-)NCBI
PanPan1.12042,044,613 - 42,076,868 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034947614   ⟹   XP_034803505
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,352,747 - 50,384,961 (-)NCBI
NHGRI_mPanPan12050,346,137 - 50,378,060 (-)NCBI
Mhudiblu_PPA_v02040,950,238 - 40,982,451 (-)NCBI
RefSeq Acc Id: XM_034947615   ⟹   XP_034803506
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,352,747 - 50,384,959 (-)NCBI
NHGRI_mPanPan12050,346,137 - 50,378,060 (-)NCBI
Mhudiblu_PPA_v02040,950,238 - 40,982,451 (-)NCBI
RefSeq Acc Id: XM_057300832   ⟹   XP_057156815
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,352,747 - 50,384,959 (-)NCBI
NHGRI_mPanPan12050,345,850 - 50,378,060 (-)NCBI
RefSeq Acc Id: XM_063601060   ⟹   XP_063457130
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,352,747 - 50,384,961 (-)NCBI
RefSeq Acc Id: XM_063601061   ⟹   XP_063457131
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,352,747 - 50,384,959 (-)NCBI
RefSeq Acc Id: XM_063601063   ⟹   XP_063457133
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,352,747 - 50,359,819 (-)NCBI
RefSeq Acc Id: XM_063601064   ⟹   XP_063457134
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,352,747 - 50,359,819 (-)NCBI
RefSeq Acc Id: XM_063601065   ⟹   XP_063457135
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22150,352,747 - 50,359,819 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003825981   ⟸   XM_003825933
- Peptide Label: isoform X4
- UniProtKB: A0A2R8ZN08 (UniProtKB/TrEMBL),   A0A2R8ZQZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034803506   ⟸   XM_034947615
- Peptide Label: isoform X5
RefSeq Acc Id: XP_034803505   ⟸   XM_034947614
- Peptide Label: isoform X3
- UniProtKB: A0A2R8ZQZ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000006333   ⟸   ENSPPAT00000027469
RefSeq Acc Id: ENSPPAP00000006331   ⟸   ENSPPAT00000027466
RefSeq Acc Id: ENSPPAP00000006326   ⟸   ENSPPAT00000027452
RefSeq Acc Id: ENSPPAP00000006328   ⟸   ENSPPAT00000027456
RefSeq Acc Id: XP_057156815   ⟸   XM_057300832
- Peptide Label: isoform X6
- UniProtKB: A0A2R8ZQZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063457130   ⟸   XM_063601060
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063457131   ⟸   XM_063601061
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063457135   ⟸   XM_063601065
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063457134   ⟸   XM_063601064
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063457133   ⟸   XM_063601063
- Peptide Label: isoform X7
Protein Domains
Adenosine deaminase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000024854 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000027452.1 UniProtKB/TrEMBL
  ENSPPAT00000027456.1 UniProtKB/TrEMBL
  ENSPPAT00000027466.1 UniProtKB/TrEMBL
  ENSPPAT00000027469.1 UniProtKB/TrEMBL
Gene3D-CATH Metal-dependent hydrolases UniProtKB/TrEMBL
InterPro A/AMP_deam_AS UniProtKB/TrEMBL
  A/AMP_deaminase_dom UniProtKB/TrEMBL
  A_deaminase UniProtKB/TrEMBL
  Ado/ade_deaminase UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/TrEMBL
KEGG Report pps:100979765 UniProtKB/TrEMBL
NCBI Gene ADA ENTREZGENE
PANTHER ADENOSINE DEAMINASE UniProtKB/TrEMBL
  PTHR11409 UniProtKB/TrEMBL
Pfam A_deaminase UniProtKB/TrEMBL
PROSITE A_DEAMINASE UniProtKB/TrEMBL
Superfamily-SCOP SSF51556 UniProtKB/TrEMBL
UniProt A0A2R8ZN08 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZN12_PANPA UniProtKB/TrEMBL
  A0A2R8ZQZ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZQZ8 ENTREZGENE, UniProtKB/TrEMBL