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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:secondary progressive multiple sclerosis
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Accession:DOID:0050783 term browser browse the term
Definition:A multiple sclerosis that is characterized by a worsening of disability, rather than by relapses followed by recovery, which progressively worsens until a steady progression of disability replaces the cycles of attacks. (DO)
Synonyms:exact_synonym: SPMS;   Secondary-progressive MS;   chronic progressive multiple sclerosis
 xref: EFO:0003840;   EFO:0008522

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secondary progressive multiple sclerosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G N Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 ISO ClinVar Annotator: match by term: Chronic progressive multiple sclerosis ClinVar NCBI chrNW_004624904:2,314,197...2,320,900
Ensembl chrNW_004624904:2,314,249...2,318,791 		JBrowse link
G G HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 ISO ClinVar Annotator: match by term: Chronic progressive multiple sclerosis ClinVar NCBI chr11:50,397,173...50,403,192
Ensembl chr11:50,396,888...50,400,802 		JBrowse link
G P HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 ISO ClinVar Annotator: match by term: Chronic progressive multiple sclerosis ClinVar NCBI chr 5:19,485,033...19,491,418
Ensembl chr 5:19,485,096...19,491,417 		JBrowse link
G S Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 ISO ClinVar Annotator: match by term: Chronic progressive multiple sclerosis ClinVar NCBI chrNW_004936512:11,481,017...11,487,737 JBrowse link
G D HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 ISO ClinVar Annotator: match by term: Chronic progressive multiple sclerosis ClinVar NCBI chr27:1,013,459...1,020,083
Ensembl chr27:1,015,868...1,019,891 		JBrowse link
G B HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 ISO ClinVar Annotator: match by term: Chronic progressive multiple sclerosis ClinVar NCBI chr12:34,456,900...34,463,317
Ensembl chr12:35,184,943...35,188,443 		JBrowse link
G C Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 ISO ClinVar Annotator: match by term: Chronic progressive multiple sclerosis ClinVar NCBI chrNW_004955458:1,530,163...1,536,874 JBrowse link
G R Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 ISO ClinVar Annotator: match by term: Chronic progressive multiple sclerosis ClinVar NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609 		JBrowse link
G M Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 ISO ClinVar Annotator: match by term: Chronic progressive multiple sclerosis ClinVar NCBI chr15:103,148,840...103,155,119
Ensembl chr15:103,148,859...103,155,119 		JBrowse link
G H HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 IAGP ClinVar Annotator: match by term: Chronic progressive multiple sclerosis ClinVar NCBI chr12:54,280,726...54,287,087
Ensembl chr12:54,280,193...54,287,088 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 175454
    disease of anatomical entity 168442
      nervous system disease 143041
        central nervous system disease 128046
          autoimmune disease of central nervous system 3054
            Demyelinating Autoimmune Diseases, CNS 2986
              multiple sclerosis 1842
                secondary progressive multiple sclerosis 10
Path 2
Term Annotations click to browse term
  disease 175454
    disease of anatomical entity 168442
      Immune & Inflammatory Diseases 51431
        immune system disease 44663
          primary immunodeficiency disease 38462
            autoimmune disease 20527
              autoimmune disease of the nervous system 5675
                autoimmune disease of central nervous system 3054
                  Demyelinating Autoimmune Diseases, CNS 2986
                    multiple sclerosis 1842
                      secondary progressive multiple sclerosis 10
paths to the root