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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trimetrexate
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Accession:CHEBI:9737 term browser browse the term
Definition:A quinazoline that has formula C19H23N5O3.
Synonyms:related_synonym: 2,4-diamino-5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}quinazolin-1-ium;   CI-898;   Formula=C19H23N5O3;   Formula=C19H24N5O3;   InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)/p+1;   InChIKey=NOYPYLRCIDNJJB-UHFFFAOYSA-O;   JB-11;   SMILES=CC1=C2C(=CC=C1CNC3=CC(OC)=C(C(=C3)OC)OC)N=C(N=C2N)N;   trimetrexate glucuronate;   trimetrexate hydrate
 alt_id: CHEBI:46138
 xref: CAS:52128-35-5;   Drug_Central:2757;   KEGG:C11154;   KEGG:D06238
 xref_mesh: MESH:D016597
 xref: PDBeChem:TMQ


show annotations for term's descendants           Sort by:
trimetrexate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase decreases response to substance ISO DHFR protein polymorphism results in decreased susceptibility to Trimetrexate CTD PMID:12872145 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases response to substance EXP GSTA3 protein results in decreased susceptibility to Trimetrexate CTD PMID:12872145 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Kras KRAS proto-oncogene, GTPase increases response to substance ISO KRAS gene mutant form results in increased susceptibility to Trimetrexate CTD PMID:24688052 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Slc19a1 solute carrier family 19 member 1 decreases response to substance ISO SLC19A1 protein results in decreased susceptibility to Trimetrexate CTD PMID:12396629 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    role 19810
      application 19653
        pharmaceutical 19494
          drug 19494
            antifungal drug 5892
              trimetrexate 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      p-block molecular entity 19782
                        carbon group molecular entity 19731
                          organic molecular entity 19727
                            organic molecule 19680
                              organic cyclic compound 19493
                                organic heterocyclic compound 18871
                                  organic heteropolycyclic compound 18300
                                    organic heterobicyclic compound 17245
                                      quinazolines 541
                                        trimetrexate 4
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