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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tiazofurine
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Accession:CHEBI:90239 term browser browse the term
Definition:A C-glycosyl compound that is 1,3-thiazole-4-carboxamide in which the hydrogen at position 2 has been replaced by a beta-D-ribofuranosyl group. It is metabolised to thiazole-4-carboxamide adenine dinucleotide (TAD), a selective inhibitor of inosine monophosphate dehydrogenase (IMP dehydrogenase).
Synonyms:exact_synonym: (1R)-1,4-anhydro-1-(4-carbamoyl-1,3-thiazol-2-yl)-D-ribitol
 related_synonym: 2-beta-D-ribofuranosyl-4-thiazolecarboxamide;   CI-909;   Formula=C9H12N2O5S;   InChI=1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1;   InChIKey=FVRDYQYEVDDKCR-DBRKOABJSA-N;   SMILES=O1[C@@H](C=2SC=C(N2)C(N)=O)[C@H](O)[C@H](O)[C@H]1CO;   TCAR;   riboxamide;   tiazofurin;   tiazofurina;   tiazofurinum
 xref: CAS:60084-10-8;   KEGG:D06130
 xref_mesh: MESH:C033706
 xref: PDBeChem:TIZ;   PMID:11249583;   PMID:23764899;   PMID:2712550;   PMID:8667040;   Reaxys:1084555;   Wikipedia:Tiazofurin


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tiazofurine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kras KRAS proto-oncogene, GTPase multiple interactions
decreases expression		 ISO Guanosine inhibits the reaction [tiazofurin results in decreased expression of KRAS] CTD PMID:9381980 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions		 ISO tiazofurin results in decreased expression of MYC
Guanosine inhibits the reaction [tiazofurin results in decreased expression of MYC]		 CTD PMID:9381980 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19814
      application 19658
        pro-agent 11543
          prodrug 11303
            tiazofurine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      carbon group element atom 19734
                        carbon atom 19731
                          organic molecular entity 19731
                            heteroorganic entity 19488
                              organochalcogen compound 19251
                                organooxygen compound 19168
                                  carbohydrates and carbohydrate derivatives 15283
                                    carbohydrate 15283
                                      monosaccharide 4803
                                        aldose 3221
                                          aldopentose 761
                                            ribose 759
                                              D-ribose 757
                                                D-ribofuranose 757
                                                  beta-D-ribose 407
                                                    tiazofurine 2
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