The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
An N-nitrosourea that is urea in which one of the nitrogens is substituted by a 2-chloroethyl group and by a nitroso group, while the other nitrogen is substituted by a cyclohexyl group. An alkylating antineoplastic agent, it is used in the treatment of brain tumours, lung cancer, malignant melanoma and other solid tumours.
MGMT protein affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine] MGMT mRNA results in decreased susceptibility to Lomustine
Lomustine results in increased expression of POLH mRNA; Lomustine results in increased expression of POLH protein POLH protein results in decreased susceptibility to Lomustine pifithrin inhibits the reaction [Lomustine results in increased expression of POLH protein]