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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ceftizoxime
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Accession:CHEBI:553473 term browser browse the term
Definition:A parenteral third-generation cephalosporin, bearing a 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino group at the 7beta-position.
Synonyms:exact_synonym: (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2,3-didehydropenam-2-carboxylic acid
 related_synonym: 7-[2-(2-Amino-thiazol-4-yl)-2-methoxyimino-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   CEFIZOX;   Formula=C13H13N5O5S2;   InChI=1S/C13H13N5O5S2/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22)/b17-7-/t8-,11-/m1/s1;   InChIKey=NNULBSISHYWZJU-LLKWHZGFSA-N;   SMILES=[H][C@]12SCC=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1csc(N)n1)C(O)=O;   ceftizoxima;   ceftizoximum;   syn-7-(2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetamido)-3-cephem-4-carboxylic acid
 alt_id: CHEBI:112105;   CHEBI:3511
 xref: Beilstein:5777502;   CAS:68401-81-0;   DrugBank:DB01332;   Drug_Central:563;   KEGG:C06890;   KEGG:D07658
 xref_mesh: MESH:D015296
 xref: PMID:11452157;   PMID:11711261;   PMID:1384868;   PMID:15716453;   PMID:22726927;   PMID:23394621;   PMID:29017833;   Reaxys:5777502;   Wikipedia:Ceftizoxime
 cyclic_relationship: is_conjugate_acid_of CHEBI:55498


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ceftizoxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase decreases activity ISO Ceftizoxime results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
increases uptake		 ISO Ceftizoxime inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]
SLC22A6 protein results in increased uptake of Ceftizoxime		 CTD PMID:16098483 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake
multiple interactions		 ISO SLC22A8 protein results in increased uptake of Ceftizoxime
Ceftizoxime inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]		 CTD PMID:16098483 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        antimicrobial agent 18166
          antibacterial agent 15629
            antibacterial drug 4413
              ceftizoxime 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      carboacyl group 17698
                                        univalent carboacyl group 17698
                                          carbamoyl group 17548
                                            carboxamide 17548
                                              lactam 8390
                                                beta-lactam 830
                                                  beta-lactam antibiotic 815
                                                    cephem 551
                                                      cephalosporin 550
                                                        ceftizoxime 3
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