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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-dehydroascorbic acid
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Accession:CHEBI:27956 term browser browse the term
Definition:Dehydroascorbic acid having the L-configuration.
Synonyms:exact_synonym: (5R)-5-[(1S)-1,2-dihydroxyethyl]furan-2,3,4(5H)-trione
 related_synonym: DHAA;   Formula=C6H6O6;   InChI=1S/C6H6O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-8H,1H2/t2-,5+/m0/s1;   InChIKey=SBJKKFFYIZUCET-JLAZNSOCSA-N;   L-Dehydroascorbate;   L-threo-2,3-hexodiulosonic acid, gamma-lactone;   L-threo-hexo-2,3-diulosono-1,4-lactone;   SMILES=[H][C@@]1(OC(=O)C(=O)C1=O)[C@@H](O)CO;   dehydro-L-ascorbic acid;   dehydroascorbic acid;   oxidized ascorbic acid;   oxidized vitamin C
 alt_id: CHEBI:21279;   CHEBI:21280;   CHEBI:6210
 xref: Beilstein:84277;   CAS:490-83-5;   Gmelin:51038;   KEGG:C05422;   KNApSAcK:C00007380
 xref_mesh: MESH:D003683
 xref: PMID:15013385;   PMID:18813862;   PMID:23543734;   PMID:9506998;   Reaxys:84277
 cyclic_relationship: is_conjugate_acid_of CHEBI:58539


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L-dehydroascorbic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression		 ISO [Dehydroascorbic Acid co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein
Dehydroascorbic Acid results in increased expression of BCL2 protein		 CTD PMID:20166893 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Dehydroascorbic Acid promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Dehydroascorbic Acid promotes the reaction [Etoposide results in increased activity of CASP3 protein] CTD PMID:16951922 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
increases expression		 ISO [Dehydroascorbic Acid co-treated with Lipopolysaccharides] results in increased expression of CAT protein; Cytochalasin B inhibits the reaction [Dehydroascorbic Acid results in increased expression of CAT protein] CTD PMID:20166893 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Dehydroascorbic Acid affects the localization of CYCS protein CTD PMID:20166893 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Buthionine Sulfoximine co-treated with Dehydroascorbic Acid] promotes the reaction [cupric oxide results in increased expression of HMOX1 mRNA]; [monocrystalline iron oxide nanoparticle co-treated with Buthionine Sulfoximine co-treated with Dehydroascorbic Acid] results in increased expression of HMOX1 mRNA; [monocrystalline iron oxide nanoparticle co-treated with Dehydroascorbic Acid] results in increased expression of HMOX1 mRNA; Dehydroascorbic Acid promotes the reaction [Copper Sulfate results in increased expression of HMOX1 mRNA]; Dehydroascorbic Acid promotes the reaction [cupric oxide results in increased expression of HMOX1 mRNA] CTD PMID:19683516 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 Dehydroascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]
Dehydroascorbic Acid inhibits the reaction [Blood Glucose affects the expression of IL1B protein]		 CTD PMID:15737438 PMID:16529823 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Dehydroascorbic Acid inhibits the reaction [Blood Glucose affects the expression of PTGS2 protein] CTD PMID:15737438 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases transport
affects uptake
affects transport		 ISO
EXP		 SLC2A1 protein mutant form results in decreased transport of Dehydroascorbic Acid
SLC2A1 mRNA affects the uptake of Dehydroascorbic Acid
SLC2A1 protein affects the transport of Dehydroascorbic Acid		 CTD PMID:11603379 PMID:15590689 PMID:16142743 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 increases uptake ISO SLC2A2 protein results in increased uptake of Dehydroascorbic Acid CTD PMID:23396969 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 affects transport ISO SLC2A3 protein affects the transport of Dehydroascorbic Acid CTD PMID:15590689 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472 		JBrowse link
G Slc2a8 solute carrier family 2 member 8 increases uptake EXP
ISO		 SLC2A8 protein results in increased uptake of Dehydroascorbic Acid CTD PMID:23396969 NCBI chr 3:16,274,918...16,284,536
Ensembl chr 3:16,274,925...16,284,464 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression		 ISO [Dehydroascorbic Acid co-treated with Lipopolysaccharides] results in increased expression of SOD2 protein; Cytochalasin B inhibits the reaction [Dehydroascorbic Acid results in increased expression of SOD2 protein] CTD PMID:20166893 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19814
      biological role 19812
        biochemical role 19522
          cofactor 16167
            coenzyme 1015
              L-dehydroascorbic acid 12
                L-dehydroascorbic acid hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      carbon group element atom 19734
                        carbon atom 19731
                          organic molecular entity 19731
                            heteroorganic entity 19488
                              organochalcogen compound 19251
                                organooxygen compound 19168
                                  ester 17352
                                    carboxylic ester 16733
                                      lactone 13238
                                        gamma-lactone 6861
                                          butenolide 6381
                                            vitamin C 779
                                              L-ascorbic acid 779
                                                L-dehydroascorbic acid 12
                                                  L-dehydroascorbic acid hydrate 0
paths to the root