Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acetoacetic acid
go back to main search page
Accession:CHEBI:15344 term browser browse the term
Definition:A 3-oxo monocarboxylic acid that is butyric acid bearing a 3-oxo substituent.
Synonyms:related_synonym: 3-Ketobutyric acid;   3-Oxobutanoic acid;   3-Oxobutyric acid;   3-ketobutanoic acid;   Formula=C4H6O3;   InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7);   InChIKey=WDJHALXBUFZDSR-UHFFFAOYSA-N;   SMILES=CC(=O)CC(O)=O;   beta-Ketobutyric acid
 alt_id: CHEBI:22172;   CHEBI:2391;   CHEBI:40507
 xref: Beilstein:1747690;   CAS:541-50-4;   DrugBank:DB01762;   HMDB:HMDB0000060;   KEGG:C00164;   KNApSAcK:C00007458;   LIPID_MAPS_instance:LMFA01060003
 xref_mesh: MESH:C016635
 xref: MetaCyc:3-KETOBUTYRATE;   PMID:17190852;   PMID:20444635;   PMID:21806064;   PMID:22382897;   PMID:3884391;   Reaxys:1747690;   UM-BBD_compID:c0069;   Wikipedia:Acetoacetic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:13705;   is_tautomer_of CHEBI:131367


show annotations for term's descendants           Sort by:
acetoacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO acetoacetic acid results in increased secretion of CCL2 protein CTD PMID:17665966 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Il6 interleukin 6 increases secretion ISO acetoacetic acid results in increased secretion of IL6 protein CTD PMID:17665966 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Slc13a5 solute carrier family 13 member 5 decreases abundance ISO SLC13A5 protein results in decreased abundance of acetoacetic acid CTD PMID:32634519 NCBI chr10:56,866,249...56,891,189
Ensembl chr10:56,866,249...56,890,945 		JBrowse link
acetoacetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 affects binding ISO acetoacetyl CoA binds to HSD17B2 protein CTD PMID:25526675 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19814
      biological role 19812
        biochemical role 19522
          metabolite 19509
            acetoacetic acid 4
              (R)-acetoacetylcarnitine 0
              2-methylacetoacetic acid + 0
              acetoacetamide 0
              acetoacetyl group + 0
              acetoacetyl-CoA 1
              ethyl acetoacetate 0
              geranyl acetoacetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      carbon group element atom 19734
                        carbon atom 19731
                          organic molecular entity 19731
                            heteroorganic entity 19488
                              organochalcogen compound 19251
                                organooxygen compound 19168
                                  carbon oxoacid 18637
                                    carboxylic acid 18634
                                      monocarboxylic acid 18006
                                        fatty acid 16810
                                          short-chain fatty acid 15921
                                            fatty acid 4:0 8225
                                              butyric acid 6721
                                                acetoacetic acid 4
                                                  (R)-acetoacetylcarnitine 0
                                                  2-methylacetoacetic acid + 0
                                                  acetoacetamide 0
                                                  acetoacetyl group + 0
                                                  acetoacetyl-CoA 1
                                                  ethyl acetoacetate 0
                                                  geranyl acetoacetate 0
paths to the root