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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:U0126
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Accession:CHEBI:90693 term browser browse the term
Definition:An aryl sulfide that is (2Z,3Z)-bis[amino(sulfanyl)methylidene]butanedinitrile in which the sulfanyl hydrogens are replaced by 2-aminophenyl groups. An inhibitor of mitogen-activated protein kinase that also exhibits anti-cancer properties.
Synonyms:exact_synonym: (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylene}succinonitrile
 related_synonym: FT-1069-1;   Formula=C18H16N6S2;   InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+;   InChIKey=DVEXZJFMOKTQEZ-JYFOCSDGSA-N;   SMILES=C=1(C=CC=CC1N)S/C(=C(/C(/C#N)=C(/SC=2C(=CC=CC2)N)\\N)\\C#N)/N;   U 0126
 alt_id: CHEBI:64208
 xref: CAS:109511-58-2;   CAS:218601-62-8;   LINCS:LSM-42806;   PDBeChem:5BM;   PMID:21618303;   PMID:22025280;   PMID:22052387;   PMID:22075021;   PMID:22101421;   PMID:22129618;   PMID:22182511;   PMID:22273495;   PMID:22286127;   PMID:22301382;   PMID:22313325;   PMID:22354777;   PMID:22396328;   PMID:24947959;   PMID:25363751;   PMID:25407271;   PMID:25492115;   PMID:25544156;   PMID:26349244;   PMID:9660836;   Reaxys:3483750;   Wikipedia:U0126


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U0126 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eef2 eukaryotic translation elongation factor 2 multiple interactions ISO U0126 inhibits the reaction [carbachol decreases phosphorylation of EEF2 protein in colon cancer cells] RGD PMID:31227218 RGD:153298919 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP U0126 inhibits the reaction [BDNF increases expression of Gria1 protein on nucleus accumbens medium spiny neurons]
U0126 inhibits the reaction [Morphine increases localization of Gria1 protein on shell of nucleus accumbens cell surface]		 RGD PMID:24712995 PMID:25746394 RGD:405650624, RGD:11087075 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases reaction EXP U0126 inhibits the reaction [estrogen increases phosphorylation of Mapk1/3 protein] in rat uterus RGD PMID:17272396 RGD:152177689 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases reaction EXP U0126 inhibits the reaction [estrogen increases phosphorylation of Mapk1/3 protein] in rat uterus RGD PMID:17272396 RGD:152177689 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP U0126 inhibits the reaction [17alpha-ethynylestradiol increases phosphorylation of Prkaa1 in primary hepatocytes] RGD PMID:27090119 RGD:15090804 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      chemical role 19420
        antioxidant 16122
          U0126 5
            U0126.EtOH 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  azane 17798
                                    ammonia 17797
                                      organic amino compound 17797
                                        aromatic amine 15400
                                          anilines 14398
                                            substituted aniline 14039
                                              U0126 5
                                                U0126.EtOH 0
paths to the root